Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I43 3.094146
2R:R:G45 2.235408
3R:R:T63 6.054105
4R:R:D75 5.93539
5R:R:L112 3.0425406
6R:R:K113 5.444156
7R:R:R127 5.3125439
8R:R:Y128 7.644178
9R:R:P134 3.4065188
10R:R:Y137 6.187107
11R:R:F161 6.08254166
12R:R:K170 10.245494
13R:R:Y173 8.164591
14R:R:H174 6.326676154
15R:R:W180 9.64403
16R:R:W185 11.598597
17R:R:T187 6.4025495
18R:R:F191 5.3075405
19R:R:Y200 5.1875405
20R:R:Y211 6.094539
21R:R:H221 6.8585207
22R:R:F232 6.438504
23R:R:Y250 5.524198
24R:R:F261 6.6825409
25R:R:Y262 3.914506
26R:R:L264 5.2875408
27R:R:W265 5.3625408
28R:R:E275 8.735492
29R:R:F287 6.3125405
30R:R:W291 10.12404
31R:R:N300 6.8575439
32R:R:Y304 4.882539
33R:R:F311 6.005409
34A:A:R42 6.8354119
35A:A:F219 5.478508
36A:A:H220 9.1225117
37A:A:F222 8.28254117
38A:A:K233 5.305459
39A:A:W234 5.74409
40A:A:Q267 4.922504
41A:A:F273 5.854219
42A:A:W277 11.08254216
43A:A:R280 5.8875465
44A:A:W281 8.26565
45A:A:L289 5.11509
46A:A:F290 4.92409
47A:A:K293 5.8025409
48A:A:Q294 6.1175446
49A:A:F312 3.53333608
50A:A:F315 11.355406
51A:A:Y318 7.355406
52A:A:Y339 5.5543
53A:A:F340 6.294507
54A:A:R342 6.27644
55A:A:F345 8.1425408
56A:A:L346 5.594544
57A:A:Y360 10.475408
58A:A:F363 6.45545
59A:A:F376 3.9225408
60A:A:R385 5.6725205
61A:A:H387 3.34254188
62A:A:L388 4.9525408
63A:A:Y391 5.4425404
64B:B:R22 6.4325416
65B:B:V40 4.41754223
66B:B:H54 7.896589
67B:B:K57 14.8975469
68B:B:W63 6.43333607
69B:B:R68 9.7025405
70B:B:V71 3.66408
71B:B:Q75 9.5475469
72B:B:I80 7.3775488
73B:B:I81 4.59254257
74B:B:W82 10.442589
75B:B:K89 5.60833689
76B:B:I93 4.995407
77B:B:L95 3.514268
78B:B:W99 7.394509
79B:B:Y111 6.48404
80B:B:Y124 4.791676266
81B:B:L139 4.9775409
82B:B:H142 7.212559
83B:B:Y145 5.99714758
84B:B:F151 4.025409
85B:B:L152 4.615403
86B:B:I157 4.3725407
87B:B:D163 7.395459
88B:B:W169 8.296508
89B:B:Q176 7.42404
90B:B:F180 7.7525427
91B:B:H183 8.162529
92B:B:D186 5.81459
93B:B:V187 5.0075429
94B:B:C204 5.122557
95B:B:D205 5.3175429
96B:B:K209 8.338526
97B:B:W211 9.056528
98B:B:Q220 6.395417
99B:B:H225 7.66714719
100B:B:I232 3.536508
101B:B:F235 5.296126
102B:B:P236 5.66754127
103B:B:T243 5.5175418
104B:B:D247 7.9175419
105B:B:R251 10.158518
106B:B:F253 6.54714716
107B:B:D258 9.37417
108B:B:Q259 2.6475406
109B:B:M262 6.0625404
110B:B:Y264 6.574505
111B:B:F278 3.2865127
112B:B:R283 6.8765229
113B:B:Y289 6.423336137
114B:B:C294 3.73575
115B:B:W297 5.97254138
116B:B:H311 7.804579
117B:B:R314 13.195468
118B:B:T329 4.865478
119B:B:W332 12.7683669
120B:B:F335 7.53404
121B:B:K337 6.7475476
122B:B:W339 7.806579
123G:G:L19 2.8475409
124G:G:R27 6.585418
125G:G:Y40 9.01254126
126G:G:D48 7.222509
127G:G:L51 4.995406
128G:G:N59 8.545409
129G:G:P60 7.1154249
130G:G:F61 4.7725248
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D75 R:R:N46 13.97386.73YesNo099
2R:R:D75 R:R:M71 13.94094.16YesNo399
3R:R:M71 R:R:Y304 16.01984.79NoYes399
4R:R:R127 R:R:Y304 67.83154.12YesYes399
5A:A:Y391 R:R:R127 70.61886.17YesYes049
6A:A:Y391 R:R:I131 73.80094.84YesNo049
7A:A:L388 R:R:I131 74.16837.14YesNo089
8A:A:L388 R:R:H221 76.96175.14YesYes087
9A:A:R385 R:R:H221 85.20546.77YesYes2057
10A:A:R385 A:A:Y358 86.31966.17YesNo054
11A:A:Y358 R:R:R228 95.74522.64NoNo043
12A:A:L346 R:R:R228 95.9158.5YesNo043
13A:A:C359 A:A:L346 46.91633.17NoYes054
14A:A:C359 A:A:L289 47.17853.17NoYes059
15A:A:F246 A:A:L289 99.99923.65NoYes099
16A:A:F246 A:A:L272 99.99957.31NoNo098
17A:A:L272 A:A:R231 99.99929.72NoNo089
18A:A:R231 A:A:W234 1007NoYes099
19A:A:W234 B:B:Y145 99.99023.86YesYes098
20B:B:S147 B:B:Y145 98.1073.82NoYes098
21B:B:S147 B:B:S160 98.0793.26NoNo096
22B:B:L190 B:B:S160 93.95253NoNo056
23B:B:C148 B:B:L190 93.90264.76NoNo065
24B:B:C148 B:B:R150 93.85256.96NoNo066
25B:B:H62 B:B:R150 93.751715.8NoNo066
26B:B:H62 B:B:Y105 93.7023.27NoNo066
27B:B:V71 B:B:Y105 93.59995.05YesNo086
28B:B:V112 B:B:V71 92.50574.81NoYes088
29B:B:V112 B:B:Y124 92.40243.79NoYes086
30B:B:I93 B:B:Y124 91.69524.84YesYes076
31B:B:I93 B:B:P94 92.01263.39YesNo075
32B:B:K78 B:B:P94 91.95575.02NoNo085
33B:B:D76 B:B:K78 91.72588.3NoNo098
34B:B:D76 B:B:S74 91.49267.36NoNo099
35B:B:H54 B:B:S74 91.303213.95YesNo899
36B:B:H54 B:B:S72 44.25375.58YesNo099
37B:B:S72 B:B:W82 43.93424.94NoYes099
38B:B:L70 B:B:W82 87.64616.83NoYes059
39B:B:L70 B:B:W63 87.416511.39NoYes057
40B:B:T321 B:B:W63 79.703310.92NoYes077
41B:B:D323 B:B:T321 78.67667.23NoNo2377
42B:B:D323 B:B:M325 78.54744.16NoNo075
43B:B:M325 G:G:P49 79.41895.03NoNo057
44G:G:D48 G:G:P49 79.18083.22YesNo097
45B:B:S279 G:G:D48 28.502710.31NoYes099
46B:B:L284 B:B:S279 28.2457.51NoNo059
47B:B:L284 B:B:V296 56.27945.96NoNo055
48B:B:L286 B:B:V296 55.21092.98NoNo075
49B:B:L286 B:B:V327 54.67744.47NoNo076
50B:B:V327 G:G:L50 53.07922.98NoNo069
51B:B:M45 G:G:L50 52.54985.65NoNo049
52B:B:L308 B:B:M45 52.02475.65NoNo074
53B:B:C294 B:B:L308 26.62574.76YesNo057
54B:B:D333 B:B:H311 26.34996.3NoYes799
55B:B:D333 B:B:F335 24.158413.14NoYes094
56B:B:F335 R:R:P57 21.89814.33YesNo046
57A:A:L346 A:A:P361 46.39756.57YesNo445
58A:A:L289 A:A:P361 48.60373.28YesNo095
59B:B:H54 B:B:I80 47.003210.61YesYes898
60B:B:I80 B:B:W82 43.929812.92YesYes889
61G:G:D48 G:G:L51 49.73949.5YesYes096
62B:B:L284 G:G:L51 28.58464.15NoYes056
63B:B:H311 B:B:T329 15.4016.85YesYes798
64B:B:L308 B:B:W339 25.012317.08NoYes079
65B:B:K337 B:B:W339 15.25755.8YesYes769
66R:R:P57 R:R:R317 13.68785.76NoNo064
67R:R:I195 R:R:Y200 40.32354.84NoYes065
68R:R:W265 R:R:Y200 21.91063.86YesYes085
69R:R:F191 R:R:I195 32.428511.3YesNo056
70R:R:F191 R:R:S164 28.19082.64YesNo055
71R:R:P171 R:R:S164 25.82947.13NoNo035
72R:R:P171 R:R:W185 16.26646.76NoYes937
73R:R:C102 R:R:F178 11.54242.79NoNo094
74R:R:F261 R:R:L120 47.15619.74YesNo098
75R:R:F261 R:R:M117 21.90463.73YesNo097
76A:A:D378 A:A:Y360 10.04311.49NoYes078
77B:B:L285 B:B:Y264 12.45824.69NoYes065
78B:B:F278 B:B:L285 12.71623.65YesNo076
79B:B:F235 B:B:F278 13.4354.29YesYes1267
80B:B:F235 G:G:C41 17.80682.79YesNo067
81B:B:L300 G:G:C41 18.07826.35NoNo067
82B:B:L300 B:B:R283 18.34978.5NoYes069
83B:B:R283 G:G:L51 21.05634.86YesYes096
84B:B:I232 B:B:V200 12.37254.61YesNo086
85B:B:F234 B:B:V200 12.56249.18NoNo056
86B:B:A193 B:B:F234 12.94142.77NoNo045
87B:B:A193 B:B:D195 13.50843.09NoNo045
88B:B:D195 B:B:R197 13.69714.76NoNo055
89B:B:R197 B:B:R214 13.885513.86NoNo059
90B:B:R214 B:B:V213 14.07365.23NoNo094
91B:B:L168 B:B:V213 14.26162.98NoNo064
92B:B:L168 B:B:T177 14.39794.42NoNo064
93B:B:T177 B:B:T178 14.58424.71NoNo044
94B:B:F180 B:B:T178 14.77083.89YesNo074
95B:B:F180 B:B:W211 15.134614.03YesYes278
96B:B:S201 B:B:W211 17.13996.18NoYes298
97B:B:S201 B:B:V187 17.26943.23NoYes299
98B:B:S160 B:B:V187 20.12616.46NoYes069
99B:B:H142 B:B:S161 13.61115.34YesNo599
100B:B:G162 B:B:S161 14.57553.71NoNo599
101B:B:G162 B:B:Y145 14.66878.69NoYes598
102R:R:L120 R:R:Y304 49.15117.03NoYes089
103R:R:M117 R:R:Y200 21.21453.59NoYes075
104R:R:F261 R:R:W265 23.51855.01YesYes098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HMV
Class A
SubFamily Orphan
Type A orphans
SubType GPR21
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.91
Date  2023-03-01
D.O.I. 10.1002/mco2.205
Net Summary
Imin 3
Number of Linked Nodes 835
Number of Links 936
Number of Hubs 130
Number of Links mediated by Hubs 491
Number of Communities 28
Number of Nodes involved in Communities 150
Number of Links involved in Communities 190
Path Summary
Number Of Nodes in MetaPath 105
Number Of Links MetaPath 104
Number of Shortest Paths 1392715
Length Of Smallest Path 3
Average Path Length 43.5171
Length of Longest Path 77
Minimum Path Strength 1.235
Average Path Strength 6.4776
Maximum Path Strength 27.18
Minimum Path Correlation 0.7
Average Path Correlation 0.980542
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 35.0855
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.0041
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ99679
Sequence
>8HMV_Chain_R
LEVLIIVFL TVLIISGNI IVIFVFHCA PLLNHHTTS YFIQTMAYA 
DLFVGVSCV VPSLSLLHH PLPVEESLT CQIFGFVVS VLKSVSMAS 
LACISIDRY IAITKPLTY NTLVTPWRL RLCIFLIWL YSTLVFLPS 
FFHWGKPGY HGDVFQWCA ESWHTDSYF TLFIVMMLY APAALIVCF 
TYFNIFRIC QQHTKDISE RQARFSRYA MVLFRITSV FYILWLPYI 
IYFLLESST GHSNRFASF LTTWLAISN SFCNCVIYS LSNSVFQRG 
LKRL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8HMV_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKST 
IVKQMTGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSQT NRLQEALNL FKSIWNNRW LRTISVILF LNKQDLLAE 
KVLAKIEDY FPEFARYTT PEDATPEPG EDPRVTRAK YFIRDEFLR 
ISTASGDGR HYCYPHFTC SVDTENIRR VFNDCRDII QRMHLRQYE 
LL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HMV_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HMV_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HIXAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ0AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ1AOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.272023-12-2710.1038/s41467-023-35882-w
8HJ2AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.82023-03-1510.1038/s41467-023-35882-w
8HMVAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;22.912023-03-0110.1002/mco2.205




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HMV.zip



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