Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:R22 7.385406
2B:B:T34 5.992545
3B:B:I37 4.00143742
4B:B:H54 7.842509
5B:B:K57 11.535479
6B:B:W63 7.824507
7B:B:V71 4.91754128
8B:B:Q75 9.565479
9B:B:D76 7.518509
10B:B:K78 4.98508
11B:B:W82 12.14409
12B:B:K89 8.1045239
13B:B:I93 3.9725127
14B:B:W99 8.036579
15B:B:Y105 3.9575406
16B:B:I120 2.104506
17B:B:Y124 4.61754126
18B:B:E130 4.9275403
19B:B:H142 7.98529
20B:B:Y145 7.47333628
21B:B:L146 3.882527
22B:B:F151 4.46667609
23B:B:V158 3.2175405
24B:B:S161 7.7575429
25B:B:D163 8.096529
26B:B:C166 3.736538
27B:B:W169 7.09857728
28B:B:D170 5.535409
29B:B:T173 5.5325405
30B:B:F180 7.39833637
31B:B:H183 8.146539
32B:B:D186 5.836529
33B:B:V187 5.0075439
34B:B:M188 5.195428
35B:B:F199 6.254539
36B:B:V200 6.27456
37B:B:C204 3.686527
38B:B:D205 6.128539
39B:B:S207 4.4435
40B:B:K209 8.19333636
41B:B:W211 11.3425438
42B:B:R214 6.1854259
43B:B:H225 9.41143759
44B:B:D228 8.43429
45B:B:I232 5.4825458
46B:B:F235 5.35266
47B:B:F241 6.562556
48B:B:D247 10.9225459
49B:B:T249 8.0675456
50B:B:R251 9.2475458
51B:B:F253 5.85833656
52B:B:Y264 6.172505
53B:B:N268 9.335494
54B:B:C271 4.012505
55B:B:F278 5.71407
56B:B:R283 9.11549
57B:B:Y289 4.685607
58B:B:D290 8.4175476
59B:B:N295 5.385496
60B:B:V296 2.695405
61B:B:L300 3.7575446
62B:B:K301 6.502545
63B:B:R304 7.058595
64B:B:H311 6.59167669
65B:B:D312 5.2125465
66B:B:R314 17.4775478
67B:B:T321 5.45254227
68B:B:D323 7.25754227
69B:B:T329 4.4925468
70B:B:W332 13.426579
71B:B:D333 8.1875469
72B:B:K337 6.3925466
73B:B:W339 6.538569
74G:G:R27 8.726508
75G:G:Y40 11.43254266
76G:G:D48 6.55549
77G:G:P49 4.405407
78G:G:L51 9.445446
79G:G:N59 10.70754219
80R:R:L38 4.5154297
81R:R:T39 4.48754106
82R:R:I43 4.556106
83R:R:N46 8.014109
84R:R:F53 8.7456137
85R:R:D75 4.56409
86R:R:F105 6.2945155
87R:R:M117 5.8854187
88R:R:D126 5.4354149
89R:R:R127 4.635149
90R:R:L135 5.63254327
91R:R:Y137 6.977147
92R:R:V160 5.7185115
93R:R:F161 7.9945116
94R:R:K170 9.9685164
95R:R:P171 6.924113
96R:R:Y173 6.1945161
97R:R:H174 6.124504
98R:R:F178 7.76154
99R:R:W180 7.264163
100R:R:W185 8.534167
101R:R:V196 3.075405
102R:R:Y200 8.3254185
103R:R:Y211 5.0756339
104R:R:H221 3.9875407
105R:R:M252 5.7025407
106R:R:F255 5.41754335
107R:R:I269 6.6854187
108R:R:Y271 2.8225405
109R:R:E275 5.9625402
110R:R:F298 8.65254296
111R:R:Y304 11.7185139
112R:R:N308 8.334138
113R:R:F311 14.8425139
114A:A:L30 3.6154235
115A:A:F212 7.954179
116A:A:F219 7.23508
117A:A:H220 8.645407
118A:A:M221 3.756676178
119A:A:K233 6.6125429
120A:A:W234 7.304529
121A:A:I244 3.644368
122A:A:I245 5.09254177
123A:A:Y253 6.2618
124A:A:L270 5.9125406
125A:A:L272 4.83408
126A:A:F273 4.85286719
127A:A:W281 9.376575
128A:A:L289 5.288519
129A:A:L291 3.6075418
130A:A:Q294 5.27516
131A:A:E314 5.02486
132A:A:F315 8.144586
133A:A:Y318 7.23586
134A:A:D331 8.8254194
135A:A:V334 5.26754194
136A:A:Y339 5.34403
137A:A:F340 8.686587
138A:A:R342 6.8125414
139A:A:F345 4.905618
140A:A:L346 7.088514
141A:A:C359 4.7525415
142A:A:Y360 5.864378
143A:A:P361 4.675415
144A:A:F363 7.2275415
145A:A:F376 5.961676328
146A:A:Y387 4.6425146
147A:A:L394 6.5954138
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D258 G:G:R27 10.341614.29NoYes078
2B:B:R22 G:G:R27 10.85614.93YesYes068
3B:B:C25 B:B:R22 11.50926.96NoYes036
4B:B:C25 G:G:K29 11.63813.23NoNo034
5B:B:L285 B:B:Y264 22.14174.69NoYes065
6B:B:F278 B:B:L285 20.65557.31YesNo076
7B:B:F278 B:B:P236 19.19245.78YesNo077
8B:B:F235 B:B:P236 18.28468.67YesNo067
9B:B:F235 G:G:Y40 13.31494.13YesYes2666
10B:B:N239 G:G:Y40 12.61393.49NoYes026
11B:B:N239 B:B:R256 12.250515.67NoNo029
12B:B:R256 G:G:I28 12.06643.76NoNo094
13G:G:I28 G:G:K29 11.66965.82NoNo2044
14B:B:S147 B:B:S160 24.44544.89NoNo096
15B:B:M188 B:B:S147 24.58746.13YesNo089
16A:A:K233 B:B:M188 22.70017.2YesYes298
17A:A:K233 B:B:Y145 23.8893.58YesYes298
18B:B:M101 B:B:Y145 52.41997.18NoYes098
19B:B:M101 B:B:Y59 52.54567.18NoNo098
20B:B:W332 B:B:Y59 55.77255.79YesNo098
21B:B:R314 B:B:W332 58.954526.99YesYes789
22B:B:D290 B:B:R314 58.530414.29YesYes768
23B:B:C271 B:B:D290 62.74714.67YesYes056
24B:B:C271 B:B:D291 67.23476.22YesNo058
25B:B:D291 B:B:Y289 64.28145.75NoYes087
26B:B:G288 B:B:Y289 79.54052.9NoYes077
27B:B:G288 B:B:V315 79.57123.68NoNo077
28B:B:C294 B:B:V315 79.60485.12NoNo057
29B:B:C294 B:B:T329 79.64283.38NoYes058
30B:B:T329 B:B:W339 16.03756.06YesYes689
31B:B:L308 B:B:W339 52.496712.53NoYes079
32B:B:L308 B:B:V296 52.07522.98NoYes075
33B:B:L284 B:B:V296 51.49372.98NoYes055
34B:B:L284 G:G:L51 28.575211.07NoYes056
35B:B:H311 B:B:T329 63.62264.11YesYes698
36B:B:F199 B:B:V158 12.58623.93YesYes095
37B:B:L190 B:B:V158 12.21382.98NoYes055
38B:B:C148 B:B:L190 12.04864.76NoNo065
39B:B:C148 B:B:R150 11.88824.18NoNo066
40B:B:H62 B:B:R150 11.573411.28NoNo066
41B:B:H62 B:B:Y105 11.7794.36NoYes066
42B:B:V71 B:B:Y105 11.71365.05YesYes086
43B:B:L79 B:B:V71 12.48862.98NoYes1278
44B:B:I93 B:B:L79 13.59685.71YesNo1277
45B:B:I93 B:B:P94 17.6113.39YesNo075
46B:B:K78 B:B:P94 17.93556.69YesNo085
47B:B:I80 B:B:K78 11.92872.91NoYes088
48B:B:I80 B:B:W82 12.0819.4NoYes089
49B:B:L51 B:B:W82 12.890527.33NoYes099
50B:B:L51 B:B:T87 14.8842.95NoNo095
51B:B:R49 B:B:T87 15.01085.17NoNo075
52B:B:R48 B:B:R49 15.307636.25NoNo077
53B:B:R48 G:G:F61 15.475419.24NoNo078
54B:B:D333 B:B:H311 10012.61YesYes699
55B:B:K57 B:B:Q75 10.384517.63YesYes799
56B:B:G162 B:B:S161 12.34493.71NoYes299
57B:B:G162 B:B:Y145 10.571710.14NoYes298
58A:A:L30 B:B:K78 11.81454.23YesYes058
59A:A:L30 B:B:K89 11.93484.23YesYes2359
60A:A:N23 B:B:K89 14.72839.79NoYes079
61A:A:N23 B:B:N88 14.8514.98NoNo077
62B:B:N88 B:B:T86 14.97777.31NoNo076
63B:B:D83 B:B:T86 15.423510.12NoNo086
64B:B:D83 B:B:R68 15.715316.68NoNo085
65B:B:R68 B:B:Y85 16.658515.43NoNo054
66G:G:F61 G:G:N59 15.729226.58NoYes2189
67G:G:N59 G:G:P60 18.53544.89YesNo099
68B:B:M325 G:G:P60 35.72610.06NoNo059
69B:B:Y85 G:G:P60 16.97289.74NoNo049
70A:A:W234 B:B:Y145 46.14755.79YesYes298
71B:B:C166 B:B:F199 12.48814.19YesYes389
72B:B:D258 B:B:F222 10.2855.97NoNo078
73B:B:W297 B:B:Y264 27.01057.72NoYes085
74B:B:R304 B:B:W297 27.55663YesNo058
75B:B:I269 B:B:R304 12.87337.52NoYes945
76B:B:I269 B:B:Y289 13.80573.63NoYes047
77B:B:L284 B:B:S279 22.78567.51NoNo059
78B:B:S279 G:G:D48 22.61082.94NoYes099
79G:G:D48 G:G:L51 23.595317.64YesYes496
80B:B:M325 G:G:P49 39.99475.03NoYes057
81G:G:D48 G:G:P49 45.18164.83YesYes097
82B:B:N295 B:B:R304 15.72699.64YesYes965
83B:B:N295 B:B:Y289 13.52963.49YesYes067
84B:B:D312 B:B:D333 98.97732.66YesYes659
85B:B:D312 R:R:L58 98.63952.71YesNo055
86R:R:H62 R:R:L58 98.18083.86NoNo075
87A:A:L394 R:R:H62 97.83317.71YesNo087
88A:A:L394 R:R:Y304 37.92639.38YesYes1389
89R:R:F53 R:R:Y304 36.22114.13YesYes1379
90R:R:F53 R:R:V49 73.901210.49YesNo079
91R:R:C301 R:R:V49 73.504310.25NoNo099
92R:R:C301 R:R:N300 73.1074.72NoNo099
93R:R:D75 R:R:N300 72.70942.69YesNo099
94R:R:D75 R:R:I42 54.03772.8YesNo098
95R:R:I42 R:R:L38 49.69978.56NoYes2987
96R:R:I294 R:R:L38 48.6262.85NoYes077
97R:R:H174 R:R:I294 44.84473.98YesNo047
98R:R:H174 R:R:V109 12.227113.84YesNo046
99A:A:L394 R:R:F311 37.92634.87YesYes1389
100R:R:F311 R:R:F53 36.15719.65YesYes1397
101A:A:L394 R:R:T64 22.55364.42YesNo088
102R:R:D126 R:R:T64 25.60352.89YesNo098
103R:R:H174 R:R:Y268 32.03444.36YesNo046
104R:R:F272 R:R:Y268 31.170810.32NoNo056
105R:R:F272 R:R:Y173 27.1856.19NoYes051
106R:R:W185 R:R:Y173 22.79983.86YesYes1671
107R:R:K170 R:R:W185 21.991918.57YesYes1647
108R:R:K170 R:R:S164 18.90193.06YesNo045
109R:R:P171 R:R:S164 15.34933.56YesNo035
110R:R:F161 R:R:P171 10.859910.11YesYes1163
111R:R:D126 R:R:R127 15.42563.57YesYes1499
112R:R:D75 R:R:S297 13.56997.36YesNo099
113R:R:K113 R:R:S297 13.12263.06NoNo069
114R:R:K113 R:R:N296 12.674915.39NoNo069
115R:R:F261 R:R:N296 12.226912.08NoNo099
116R:R:F261 R:R:M117 10.88086.22NoYes097
117A:A:Y387 R:R:P134 16.34192.78YesNo068
118A:A:L384 R:R:P134 10.62063.28NoNo058
119A:A:L384 R:R:H221 10.14153.86NoYes057
120A:A:L45 A:A:M221 10.3214.24NoYes088
121A:A:K53 A:A:L45 10.52954.23NoNo098
122A:A:G47 A:A:K53 12.01785.23NoNo099
123A:A:G47 A:A:L46 12.87333.42NoNo098
124A:A:L272 A:A:L46 13.29994.15YesNo088
125A:A:L272 A:A:R231 47.56174.86YesNo089
126A:A:R231 A:A:W234 47.72176NoYes099
127A:A:F246 A:A:F273 16.02548.57NoYes099
128A:A:F246 A:A:L272 35.50717.31NoYes098
129A:A:F246 A:A:L289 19.31164.87NoYes099
130A:A:E344 A:A:L270 12.06746.63NoYes056
131B:B:C166 B:B:S160 15.46943.44YesNo386
132B:B:Q75 B:B:W99 12.54914.38YesYes799
133B:B:H311 B:B:W339 36.89713.17YesYes699
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HJ2
Class A
SubFamily Orphan
Type A orphans
SubType GPR21
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtG15)/Beta1/Gamma2
PDB Resolution 3.8
Date 2023-03-15
D.O.I. 10.1038/s41467-023-35882-w
Net Summary
Imin 2.85
Number of Linked Nodes 866
Number of Links 1022
Number of Hubs 147
Number of Links mediated by Hubs 551
Number of Communities 37
Number of Nodes involved in Communities 229
Number of Links involved in Communities 306
Path Summary
Number Of Nodes in MetaPath 134
Number Of Links MetaPath 133
Number of Shortest Paths 991560
Length Of Smallest Path 3
Average Path Length 30.2876
Length of Longest Path 63
Minimum Path Strength 1.24
Average Path Strength 6.7261
Maximum Path Strength 27.745
Minimum Path Correlation 0.7
Average Path Correlation 0.974557
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 44.3745
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.4117
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HJ2_Chain_B
LRQEAEQLK NQIRDARKA CADATLSQI TNNIDPVGR IQMRTRRTL 
RGHLAKIYA MHWGTDSRL LVSASQDGK LIIWDSYTT NKVHAIPLR 
SSWVMTCAY APSGNYVAC GGLDNICSI YNLKTREGN VRVSRELAG 
HTGYLSCCR FLDDNQIVT SSGDTTCAL WDIETGQQT TTFTGHTGD 
VMSLSLAPD TRLFVSGAC DASAKLWDV REGMCRQTF TGHESDINA 
ICFFPNGNA FATGSDDAT CRLFDLRAD QELMTYSHD NIICGITSV 
SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT 
DDGMAVATG SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HJ2_Chain_G
EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT PVPASENPF 
R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99679
Sequence
>8HJ2_Chain_R
VNFCLLEVL IIVFLTVLI ISGNIIVIF VFHCAPLLN HHTTSYFIQ 
TMAYADLFV GVSCVVPSL SLLHHPLPV EESLTCQIF GFVVSVLKS 
VSMASLACI SIDRYIAIT KPLTYNTLV TPWRLRLCI FLIWLYSTL 
VFLPSFFHW GKPGYHGDV FQWCAESWH TDSYFTLFI VMMLYAPAA 
LIVCFTYFN IFRICQQHT KDISERQAR FSMVLFRIT SVFYILWLP 
YIIYFLLES STGHSNRFA SFLTTWLAI SNSFCNCVI YSLSNSVFQ 
RGLKRLSGA MCT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8HJ2_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LSGGTSGIF ETKFQVDKV NFHMFDVGG QRDERRKWI 
QCFNDVTAI IFVVDSSDY NRLQEALNL FKSIWNNRW LRTISVILF 
LNKQDLLAE KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT 
RAKYFIRDE FLRISTASG DGRHYCYPH FTCAVDTEN ARRIFNDCR 
DSVLARYLD EINLL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HIXAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ0AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ1AOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.272023-12-2710.1038/s41467-023-35882-w
8HJ2AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.82023-03-1510.1038/s41467-023-35882-w
8HMVAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;22.912023-03-0110.1002/mco2.205




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HJ2.zip



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