Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I26 6.5525409
2A:A:H41 6.41456
3A:A:F212 7.95459
4A:A:F219 6.46167658
5A:A:H220 8.645407
6A:A:M221 3.75667658
7A:A:K233 5.33667619
8A:A:W234 7.304519
9A:A:F238 7.5125419
10A:A:I244 3.644218
11A:A:I245 5.0925457
12A:A:F246 5.8425409
13A:A:V248 3.7925437
14A:A:Y253 6.2638
15A:A:L270 5.9125406
16A:A:L272 4.83408
17A:A:F273 4.85286739
18A:A:W281 9.376515
19A:A:I288 3.8325409
20A:A:L289 5.288539
21A:A:L291 3.6075438
22A:A:Q294 5.27536
23A:A:E314 5.024106
24A:A:F315 8.1445106
25A:A:Y318 7.235106
26A:A:D331 8.8254164
27A:A:V334 5.26754164
28A:A:Y339 5.34403
29A:A:F340 8.6865107
30A:A:R342 6.8125434
31A:A:F345 4.905638
32A:A:L346 4.166534
33A:A:S349 4.1925437
34A:A:C359 4.7525435
35A:A:Y360 5.1725228
36A:A:P361 4.675435
37A:A:F363 7.2275435
38A:A:F376 5.96167658
39A:A:Y387 4.6425136
40A:A:L388 2.76754238
41B:B:K15 9.31754246
42B:B:R22 14.3425186
43B:B:T34 4.515465
44B:B:I37 5.83833662
45B:B:R49 11.566547
46B:B:L51 15.135449
47B:B:H54 7.842509
48B:B:L55 6.81406
49B:B:K57 11.535419
50B:B:W63 6.98833647
51B:B:V71 4.91754148
52B:B:Q75 9.565419
53B:B:D76 7.518509
54B:B:K78 5.544508
55B:B:L79 4.3554147
56B:B:W82 13.85409
57B:B:S84 5.7825445
58B:B:Y85 9.2325444
59B:B:I93 3.9725147
60B:B:L95 3.144148
61B:B:W99 8.036519
62B:B:Y105 3.9575406
63B:B:I120 2.104506
64B:B:Y124 4.61754146
65B:B:E130 4.9275403
66B:B:H142 6.48286719
67B:B:Y145 7.47333618
68B:B:L146 3.882517
69B:B:F151 4.46667609
70B:B:L152 4.505423
71B:B:Q156 6.585425
72B:B:V158 3.2175425
73B:B:T159 3.7825419
74B:B:S161 7.7575419
75B:B:D163 8.096519
76B:B:C166 3.736528
77B:B:L168 3.002526
78B:B:W169 7.09857718
79B:B:D170 5.535409
80B:B:T173 5.5325405
81B:B:F180 7.39833627
82B:B:H183 7.25333629
83B:B:D186 5.836519
84B:B:V187 5.0075429
85B:B:M188 5.195418
86B:B:F199 6.254529
87B:B:V200 6.27476
88B:B:S201 3.91429
89B:B:C204 3.686517
90B:B:D205 6.128529
91B:B:S207 4.4425
92B:B:K209 8.19333626
93B:B:W211 11.3425428
94B:B:R214 6.1854279
95B:B:H225 9.41143779
96B:B:D228 7.276519
97B:B:I232 5.4825478
98B:B:F235 11.4885196
99B:B:F241 6.562576
100B:B:D246 5.155419
101B:B:D247 10.9225479
102B:B:T249 8.0675476
103B:B:R251 9.2475478
104B:B:F253 5.85833676
105B:B:D254 3.1575409
106B:B:L261 7.07254185
107B:B:M262 5.094254
108B:B:Y264 5.588336255
109B:B:H266 9.63494
110B:B:N268 9.335494
111B:B:I269 4.452594
112B:B:C271 4.012505
113B:B:F278 5.71407
114B:B:R283 9.612569
115B:B:L284 7.1225465
116B:B:Y289 4.685697
117B:B:D290 8.4175416
118B:B:D291 5.375498
119B:B:N295 5.385496
120B:B:V296 2.695405
121B:B:L300 5.51406
122B:B:K301 6.40833665
123B:B:R304 7.058595
124B:B:H311 6.591676119
125B:B:R314 17.4775418
126B:B:D323 7.2575447
127B:B:T329 4.49254118
128B:B:W332 13.426519
129B:B:D333 8.18754119
130B:B:K337 7.14254116
131B:B:W339 7.581676119
132G:G:V30 7.3954188
133G:G:Y40 14.7965196
134G:G:D48 7.4875469
135G:G:L51 9.455466
136G:G:N59 4.13549
137G:G:F61 5.96571748
138R:R:I35 6.5925286
139R:R:T39 4.4654296
140R:R:I43 3.1454296
141R:R:N46 7.5285309
142R:R:F53 7.558336157
143R:R:Q103 7.7545125
144R:R:F105 6.5275405
145R:R:L112 4.26406
146R:R:M117 5.885487
147R:R:D126 5.4354139
148R:R:R127 4.635139
149R:R:L135 5.6325457
150R:R:Y137 6.977137
151R:R:V160 5.718585
152R:R:F161 7.005686
153R:R:K170 10.515124
154R:R:P171 6.92483
155R:R:Y173 6.1945121
156R:R:H174 5.858504
157R:R:F178 11.8154124
158R:R:W180 8.25754123
159R:R:W185 8.534127
160R:R:V196 3.075405
161R:R:Y200 7.072585
162R:R:Y211 4.862867179
163R:R:H221 3.98754237
164R:R:M252 8.11254177
165R:R:F255 5.335175
166R:R:I269 6.685487
167R:R:Y271 2.8225405
168R:R:E275 5.9625402
169R:R:I294 3.935407
170R:R:Y304 9.2865159
171R:R:F311 9.768336159
172R:R:L318 3.5454316
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:N340 G:G:N59 10.82944.09NoYes099
2B:B:N340 G:G:L50 11.02142.75NoNo099
3B:B:L284 G:G:L50 11.40725.54YesNo059
4B:B:L284 B:B:V296 16.8842.98YesYes055
5B:B:L308 B:B:V296 17.46312.98NoYes075
6B:B:L308 B:B:W339 17.614312.53NoYes1179
7B:B:C271 B:B:D291 41.94596.22YesYes058
8B:B:D291 B:B:Y289 24.61125.75YesYes987
9B:B:G288 B:B:Y289 24.32042.9NoYes077
10B:B:G288 B:B:V315 24.11143.68NoNo077
11B:B:C294 B:B:V315 23.90475.12NoNo057
12B:B:C294 B:B:T329 23.69973.38NoYes058
13B:B:T329 B:B:W339 18.58366.06YesYes1189
14B:B:C271 B:B:D290 41.47774.67YesYes056
15B:B:R314 B:B:W332 41.938226.99YesYes189
16B:B:D290 B:B:R314 40.669614.29YesYes168
17B:B:W332 B:B:Y59 42.80695.79YesNo098
18A:A:L45 A:A:M221 82.73134.24NoYes588
19A:A:K53 A:A:L45 81.81724.23NoNo598
20A:A:G47 A:A:K53 82.4525.23NoNo099
21A:A:G47 A:A:L46 82.34193.42NoNo098
22A:A:L272 A:A:L46 82.28864.15YesNo088
23A:A:L272 A:A:R231 1004.86YesNo089
24A:A:R231 A:A:W234 99.90986NoYes099
25A:A:W234 B:B:Y145 87.43895.79YesYes198
26A:A:K233 B:B:Y145 45.40653.58YesYes198
27A:A:K233 B:B:M188 43.63737.2YesYes198
28B:B:M188 B:B:S147 45.63376.13YesNo089
29B:B:S147 B:B:S160 45.44574.89NoNo096
30B:B:C166 B:B:S160 41.88963.44YesNo286
31B:B:C166 B:B:F199 35.46954.19YesYes289
32B:B:F199 B:B:V158 25.93113.93YesYes295
33B:B:L190 B:B:V158 25.91842.98NoYes055
34B:B:C148 B:B:L190 25.71234.76NoNo065
35B:B:C148 B:B:R150 25.51464.18NoNo066
36B:B:H62 B:B:R150 25.126411.28NoNo066
37B:B:H62 B:B:Y105 24.94074.36NoYes066
38B:B:V71 B:B:Y105 23.21545.05YesYes086
39B:B:L79 B:B:V71 22.44072.98YesYes1478
40B:B:I93 B:B:L79 14.27085.71YesYes1477
41B:B:I93 B:B:P94 11.84643.39YesNo075
42B:B:K78 B:B:P94 11.66356.69YesNo085
43A:A:I245 A:A:M221 79.72062.92YesYes578
44A:A:D368 A:A:T364 13.91047.23NoNo099
45A:A:C365 A:A:D368 14.30037.78NoNo089
46A:A:C365 A:A:Q294 14.39353.05NoYes086
47A:A:F363 A:A:Q294 12.62578.2YesYes356
48A:A:F363 A:A:L291 11.06843.65YesYes358
49A:A:F246 A:A:L272 22.76267.31YesYes098
50B:B:M101 B:B:Y59 42.33717.18NoNo098
51A:A:I245 A:A:I288 81.95535.89YesYes079
52A:A:I288 A:A:Y360 95.87622.42YesYes098
53A:A:F290 A:A:I288 14.25533.77NoYes099
54A:A:Y358 A:A:Y360 96.04915.96NoYes048
55A:A:Y358 R:R:I225 96.084216.92NoNo046
56R:R:H221 R:R:I225 96.10135.3YesNo076
57A:A:L384 R:R:H221 95.23293.86NoYes2357
58A:A:L384 R:R:P134 96.26943.28NoNo058
59A:A:Y387 R:R:P134 96.4112.78YesNo068
60A:A:Y387 R:R:R127 49.32443.09YesYes1369
61A:A:Y387 R:R:Y137 46.99876.95YesYes1367
62A:A:L394 R:R:T64 47.26464.42NoNo088
63R:R:D126 R:R:T64 94.70532.89YesNo098
64R:R:D126 R:R:R127 48.04983.57YesYes1399
65R:R:D126 R:R:Y137 46.77548.05YesYes1397
66A:A:L394 R:R:Y304 46.4388.21NoYes089
67B:B:F199 B:B:V213 13.47152.62YesNo094
68B:B:R214 B:B:V213 13.21492.62YesNo094
69B:B:R197 B:B:R214 11.92753.2NoYes059
70B:B:D195 B:B:R197 11.66918.34NoNo055
71B:B:A193 B:B:D195 11.41043.09NoNo045
72B:B:A193 B:B:F234 10.8926.93NoNo045
73B:B:F234 B:B:V200 10.37256.55NoYes056
74B:B:G162 B:B:Y145 11.799310.14NoYes198
75B:B:G162 B:B:S161 13.38183.71NoYes199
76B:B:H142 B:B:S161 10.352513.95YesYes199
77B:B:H142 B:B:W169 13.08915.29YesYes198
78B:B:I157 B:B:W169 11.18682.35NoYes078
79B:B:F151 B:B:I157 10.72416.28YesNo097
80B:B:W297 B:B:Y264 15.22047.72NoYes085
81B:B:I269 B:B:R304 15.40147.52YesYes945
82R:R:F311 R:R:Y304 45.329620.63YesYes1599
83R:R:F311 R:R:V49 86.26482.62YesNo099
84R:R:N46 R:R:V49 83.5472.96YesNo099
85R:R:D75 R:R:N46 80.818414.81NoYes099
86R:R:D75 R:R:I42 79.452.8NoNo098
87R:R:I294 R:R:I42 77.62122.94YesNo078
88R:R:I294 R:R:W291 12.06915.87YesNo074
89R:R:I68 R:R:T64 47.26463.04NoNo088
90R:R:F53 R:R:I68 47.05758.79YesNo078
91R:R:F311 R:R:F53 45.32967.5YesYes1597
92R:R:H174 R:R:I294 63.2842.65YesYes047
93R:R:H174 R:R:Y268 59.06714.36YesNo046
94R:R:F272 R:R:Y268 58.129710.32NoNo056
95R:R:F272 R:R:Y173 53.76256.19NoYes051
96R:R:W185 R:R:Y173 47.57323.86YesYes1271
97R:R:K170 R:R:W185 46.73618.57YesYes1247
98R:R:K170 R:R:S164 32.75783.06YesNo045
99R:R:P171 R:R:S164 29.8343.56YesNo035
100R:R:F161 R:R:P171 24.914310.11YesYes863
101R:R:F161 R:R:S114 10.07896.61YesNo066
102R:R:F161 R:R:Y200 11.5842.06YesYes865
103B:B:M101 B:B:Y145 42.76677.18NoYes098
104B:B:R304 B:B:W297 15.46043YesNo058
105B:B:D291 B:B:I269 16.27762.8YesYes984
106A:A:F290 A:A:T364 14.02956.49NoNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HJ2
Class A
SubFamily Orphan
Type Orphan
SubType GPR21
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtG15)/Beta1/Gamma2
PDB Resolution 3.8
Date 2023-03-15
D.O.I. 10.1038/s41467-023-35882-w
Net Summary
Imin 2.62
Number of Linked Nodes 848
Number of Links 1030
Number of Hubs 172
Number of Links mediated by Hubs 615
Number of Communities 34
Number of Nodes involved in Communities 252
Number of Links involved in Communities 358
Path Summary
Number Of Nodes in MetaPath 107
Number Of Links MetaPath 106
Number of Shortest Paths 1067692
Length Of Smallest Path 3
Average Path Length 34.5105
Length of Longest Path 70
Minimum Path Strength 1.265
Average Path Strength 6.08273
Maximum Path Strength 27.41
Minimum Path Correlation 0.7
Average Path Correlation 0.976127
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.6129
Average % Of Corr. Nodes 38.5652
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.7239
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • response to peptide hormone   • insulin receptor signaling pathway   • cell surface receptor protein tyrosine kinase signaling pathway   • enzyme-linked receptor protein signaling pathway   • cell surface receptor signaling pathway   • cellular response to peptide hormone stimulus   • response to insulin   • cellular response to insulin stimulus   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • developmental process   • regulation of multicellular organism growth   • multicellular organismal process   • regulation of growth   • regulation of developmental growth   • regulation of developmental process   • developmental growth   • growth   • positive regulation of biological process   • positive regulation of multicellular organism growth   • positive regulation of developmental process   • multicellular organism growth   • positive regulation of growth   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of developmental growth   • negative regulation of signaling   • negative regulation of biological process   • regulation of signal transduction   • regulation of cellular response to insulin stimulus   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of signaling   • negative regulation of response to stimulus   • regulation of insulin receptor signaling pathway   • negative regulation of signal transduction   • negative regulation of cellular response to insulin stimulus   • regulation of response to stimulus   • negative regulation of insulin receptor signaling pathway   • regulation of cell communication   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to glucagon   • cellular response to glucagon stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8HJ2_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LSGGTSGIF ETKFQVDKV NFHMFDVGG QRDERRKWI 
QCFNDVTAI IFVVDSSDY NRLQEALNL FKSIWNNRW LRTISVILF 
LNKQDLLAE KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT 
RAKYFIRDE FLRISTASG DGRHYCYPH FTCAVDTEN ARRIFNDCR 
DSVLARYLD EINLL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HJ2_Chain_B
LRQEAEQLK NQIRDARKA CADATLSQI TNNIDPVGR IQMRTRRTL 
RGHLAKIYA MHWGTDSRL LVSASQDGK LIIWDSYTT NKVHAIPLR 
SSWVMTCAY APSGNYVAC GGLDNICSI YNLKTREGN VRVSRELAG 
HTGYLSCCR FLDDNQIVT SSGDTTCAL WDIETGQQT TTFTGHTGD 
VMSLSLAPD TRLFVSGAC DASAKLWDV REGMCRQTF TGHESDINA 
ICFFPNGNA FATGSDDAT CRLFDLRAD QELMTYSHD NIICGITSV 
SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT 
DDGMAVATG SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HJ2_Chain_G
EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT PVPASENPF 
R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99679
Sequence
>8HJ2_Chain_R
VNFCLLEVL IIVFLTVLI ISGNIIVIF VFHCAPLLN HHTTSYFIQ 
TMAYADLFV GVSCVVPSL SLLHHPLPV EESLTCQIF GFVVSVLKS 
VSMASLACI SIDRYIAIT KPLTYNTLV TPWRLRLCI FLIWLYSTL 
VFLPSFFHW GKPGYHGDV FQWCAESWH TDSYFTLFI VMMLYAPAA 
LIVCFTYFN IFRICQQHT KDISERQAR FSMVLFRIT SVFYILWLP 
YIIYFLLES STGHSNRFA SFLTTWLAI SNSFCNCVI YSLSNSVFQ 
RGLKRLSGA MCT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HJ1AOrphanOrphanGPR21Homo sapiens--Gs/β1/γ23.272023-12-2710.1038/s41467-023-35882-w
8HJ1 (No Gprot) AOrphanOrphanGPR21Homo sapiens--3.272023-12-2710.1038/s41467-023-35882-w
8HJ2AOrphanOrphanGPR21Homo sapiens--chim(Gs-CtG15)/β1/γ23.82023-03-1510.1038/s41467-023-35882-w
8HJ2 (No Gprot) AOrphanOrphanGPR21Homo sapiens--3.82023-03-1510.1038/s41467-023-35882-w
8HJ0AOrphanOrphanGPR21Homo sapiens--chim(Gs-CtG15)/β1/γ23.122023-03-1510.1038/s41467-023-35882-w
8HJ0 (No Gprot) AOrphanOrphanGPR21Homo sapiens--3.122023-03-1510.1038/s41467-023-35882-w
8HIXAOrphanOrphanGPR21Homo sapiens--Gs/β1/γ23.122023-03-1510.1038/s41467-023-35882-w
8HIX (No Gprot) AOrphanOrphanGPR21Homo sapiens--3.122023-03-1510.1038/s41467-023-35882-w
8HMVAOrphanOrphanGPR21Homo sapiens--Gs/β1/γ22.912023-03-0110.1002/mco2.205
8HMV (No Gprot) AOrphanOrphanGPR21Homo sapiens--2.912023-03-0110.1002/mco2.205




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