Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 7.62424
2A:A:K34 5.5975404
3A:A:Y37 8.345404
4A:A:N50 6.8925189
5A:A:K53 6.87254179
6A:A:F219 6.434508
7A:A:F222 11.00254157
8A:A:Q227 8.255419
9A:A:K233 6.905619
10A:A:W234 7.866519
11A:A:F238 11.81254159
12A:A:D249 6.834188
13A:A:Y253 8.055408
14A:A:F273 6.43739
15A:A:W277 10.814536
16A:A:W281 13.61836105
17A:A:F290 4.98667699
18A:A:L291 5.158538
19A:A:K293 5.655409
20A:A:Q294 6.135436
21A:A:L297 3.7425408
22A:A:F312 4.395408
23A:A:F315 13.2775406
24A:A:T320 4.4675431
25A:A:P328 5.5175401
26A:A:K338 7.7025435
27A:A:Y339 6.55533
28A:A:F340 10.5925407
29A:A:R342 7.104534
30A:A:F345 8.346538
31A:A:Y358 7.185474
32A:A:Y360 6.596578
33A:A:F363 8.89535
34A:A:T364 6.225499
35A:A:D368 5.6025499
36A:A:N371 5.564599
37A:A:R374 7.54694
38A:A:L388 3.888578
39B:B:L7 2.575408
40B:B:R22 9446
41B:B:V40 5.0145193
42B:B:L51 6.9875409
43B:B:H54 9.91529
44B:B:K57 13.50754109
45B:B:W63 7.13333607
46B:B:V71 4.1225408
47B:B:D76 7.405409
48B:B:W82 9.75833629
49B:B:T86 8.1825426
50B:B:N88 11.7425427
51B:B:K89 7.044529
52B:B:W99 10.9285159
53B:B:Y105 4.0025406
54B:B:I123 5.02416
55B:B:Y124 6.43833606
56B:B:L139 6.7875409
57B:B:H142 8.74667619
58B:B:Y145 6.855618
59B:B:F151 6.464519
60B:B:L152 4.4725403
61B:B:I157 6.265417
62B:B:T159 5.56619
63B:B:D163 8.192519
64B:B:W169 9.45833618
65B:B:I171 4.46416
66B:B:Q176 6.7175414
67B:B:F180 9.45567
68B:B:H183 9.695669
69B:B:F199 8.27669
70B:B:D205 6.662569
71B:B:S207 6.6465
72B:B:K209 10.1083666
73B:B:L210 6.655405
74B:B:W211 11.412568
75B:B:Q220 8.7525447
76B:B:F222 8.2775448
77B:B:H225 11.0917649
78B:B:D228 7.28419
79B:B:I229 5.66447
80B:B:I232 5.4775448
81B:B:F234 6.3875405
82B:B:F235 7.8285136
83B:B:P236 7.7854137
84B:B:F241 9.086546
85B:B:T243 6.6575448
86B:B:D247 8.534549
87B:B:R251 9.96857748
88B:B:F253 8.14333646
89B:B:D254 4.5225409
90B:B:D258 8.415647
91B:B:Y264 4.83605
92B:B:F278 6.2765137
93B:B:R283 7.33254199
94B:B:L285 5.12406
95B:B:Y289 6.946676127
96B:B:D290 9.2154106
97B:B:C294 4.7175455
98B:B:N295 9.0754126
99B:B:W297 6.54754128
100B:B:H311 9.594559
101B:B:R314 18.6965108
102B:B:W332 13.40717109
103B:B:F335 7.26454
104B:B:K337 8.932556
105B:B:I338 5.4225425
106B:B:W339 12.005459
107G:G:V16 2.1975407
108G:G:R27 6.032548
109G:G:K32 3.23405
110G:G:Y40 13.744136
111G:G:D48 5.844509
112G:G:N59 6.058529
113G:G:F61 6.47143728
114R:R:C28 1.92404
115R:R:V49 3.695409
116R:R:F53 7.3256147
117R:R:T64 7.4054118
118R:R:F67 5.65254238
119R:R:V78 5.14408
120R:R:L89 4.5025404
121R:R:Q103 7.1775405
122R:R:F107 6.1275406
123R:R:W118 4.8525164
124R:R:D126 7.6054119
125R:R:R127 7.3925119
126R:R:Y128 7.0254248
127R:R:L135 6.715407
128R:R:Y137 6.776676117
129R:R:Y156 4.53754164
130R:R:F161 8.1275486
131R:R:W168 6.4475485
132R:R:H174 6.548504
133R:R:D188 5.8625483
134R:R:F191 6.275485
135R:R:L199 5.67754167
136R:R:Y200 6.65667685
137R:R:Y211 7.015409
138R:R:N213 5.694245
139R:R:I217 4.45476
140R:R:H221 6.125477
141R:R:R231 8.2675436
142R:R:F232 7.748534
143R:R:F261 7.73409
144R:R:W265 6.9588
145R:R:E275 5.9625402
146R:R:Y304 9.4125149
147R:R:F311 7.4925149
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:W82 33.48547.41YesYes299
2B:B:H54 B:B:S74 33.071912.55YesNo299
3B:B:D76 B:B:S74 32.86335.89YesNo099
4B:B:D76 B:B:K78 11.17885.53YesNo098
5B:B:D76 B:B:L55 20.041913.57YesNo096
6A:A:K34 B:B:L55 17.55937.05YesNo046
7A:A:K34 R:R:H61 16.53376.55YesNo048
8B:B:L70 B:B:W82 38.5445.69NoYes059
9B:B:L70 B:B:W63 39.26712.53NoYes057
10B:B:M61 B:B:W63 59.43245.82NoYes067
11B:B:C317 B:B:M61 59.86366.48NoNo076
12B:B:C317 B:B:S316 60.29323.44NoNo079
13B:B:S316 B:B:W332 60.50743.71NoYes099
14A:A:W281 B:B:W332 49.3319.37YesYes1059
15A:A:R280 A:A:W281 55.369517.99NoYes055
16A:A:R280 A:A:R283 55.508310.66NoNo053
17A:A:R283 A:A:R356 55.57912.79NoNo032
18A:A:H357 A:A:R356 55.73194.51NoNo072
19A:A:H357 A:A:W277 55.901232.8NoYes076
20A:A:F273 A:A:W277 56.3824.01YesYes396
21A:A:F273 A:A:F345 96.464710.72YesYes398
22A:A:F345 A:A:L270 91.54458.53YesNo086
23A:A:E344 A:A:L270 91.62683.98NoNo056
24A:A:E344 A:A:F340 91.66711.66NoYes057
25A:A:F315 A:A:F340 94.427213.93YesYes067
26A:A:E309 A:A:F315 99.87939.33NoYes046
27A:A:E309 A:A:K307 99.89775.4NoNo046
28A:A:D310 A:A:K307 99.91578.3NoNo036
29A:A:D310 A:A:Y311 99.93343.45NoNo036
30A:A:N254 A:A:Y311 99.95064.65NoNo096
31A:A:N254 A:A:R265 99.96754.82NoNo099
32A:A:N50 A:A:R265 1008.44YesNo099
33A:A:D249 A:A:N50 99.91310.77YesYes1889
34A:A:D249 A:A:K293 99.55354.15YesYes089
35A:A:K293 A:A:N292 99.76876.99YesNo099
36A:A:I56 A:A:N292 99.86169.91NoNo079
37A:A:I56 A:A:N371 99.88754.25NoYes079
38A:A:F290 A:A:N371 64.73447.25YesYes999
39A:A:F290 A:A:H362 34.60365.66YesNo999
40A:A:D378 A:A:H362 69.032711.35NoNo079
41A:A:D378 A:A:Y360 68.971516.09NoYes078
42A:A:Y358 A:A:Y360 68.09036.95YesYes748
43A:A:Y358 R:R:H221 67.30424.36YesYes747
44A:A:L388 R:R:H221 67.22965.14YesYes787
45A:A:L388 R:R:I217 71.49814.28YesYes786
46R:R:I217 R:R:R216 70.75766.26YesNo063
47R:R:N213 R:R:R216 70.49484.82YesNo053
48R:R:N213 R:R:Y128 69.65974.65YesYes2458
49R:R:T210 R:R:Y128 69.17483.75NoYes068
50R:R:S124 R:R:T210 68.90966.4NoNo086
51R:R:S124 R:R:Y211 68.6448.9NoYes089
52R:R:T258 R:R:Y211 36.95111.24NoYes079
53R:R:L120 R:R:T258 36.674210.32NoNo087
54R:R:F261 R:R:L120 33.90524.87YesNo098
55R:R:F261 R:R:N296 33.236115.71YesNo099
56R:R:K113 R:R:N296 32.31795.6NoNo069
57R:R:K113 R:R:V78 20.55926.07NoYes068
58R:R:S297 R:R:V78 16.96294.85NoYes098
59R:R:D75 R:R:S297 15.310710.31NoNo099
60R:R:D75 R:R:N46 14.97915.39NoNo099
61R:R:N46 R:R:P301 13.64873.26NoNo099
62R:R:P301 R:R:V49 12.3123.53NoYes099
63A:A:N371 A:A:R374 34.63393.62YesYes994
64A:A:H362 A:A:R374 34.700619.18NoYes994
65A:A:F290 A:A:I245 30.47423.77YesNo997
66A:A:I245 A:A:L43 30.5115.71NoNo077
67A:A:F219 A:A:L43 30.46326.09YesNo087
68A:A:F219 A:A:H41 14.91074.53YesNo086
69A:A:H41 R:R:L135 14.751111.57NoYes067
70A:A:F219 A:A:V217 15.49635.24YesNo085
71A:A:V217 R:R:L135 15.01775.96NoYes057
72B:B:W332 B:B:Y59 19.08457.72YesNo098
73B:B:M101 B:B:Y59 19.23259.58NoNo098
74B:B:M101 B:B:Y145 19.38287.18NoYes098
75A:A:W234 B:B:Y145 44.20346.75YesYes198
76A:A:R231 A:A:W234 44.68177NoYes099
77A:A:L272 A:A:R231 44.74089.72NoNo089
78B:B:M188 B:B:Y145 42.86117.18NoYes188
79A:A:F246 A:A:L272 44.86757.31NoNo098
80A:A:W281 B:B:D290 17.847411.17YesYes1056
81A:A:V383 R:R:L135 32.30424.47NoYes077
82A:A:V383 A:A:Y387 31.98265.05NoNo076
83A:A:Y387 R:R:Y137 31.66056.95NoYes067
84R:R:D126 R:R:Y137 28.40265.75YesYes1197
85R:R:D126 R:R:T64 13.70364.34YesYes1198
86R:R:D126 R:R:R127 14.388813.1YesYes1199
87B:B:M188 B:B:S147 42.89384.6NoNo089
88B:B:S147 B:B:S160 42.64924.89NoNo096
89B:B:S160 B:B:V187 42.40424.85NoNo069
90B:B:H183 B:B:V187 42.15896.92YesNo099
91B:B:H183 B:B:K209 31.268420.96YesYes696
92B:B:K209 B:B:T221 26.960512.01YesNo067
93B:B:T221 G:G:E22 26.69514.23NoNo079
94B:B:D258 G:G:E22 26.42937.8YesNo079
95B:B:I18 G:G:L19 12.31442.85NoNo079
96B:B:L14 G:G:L19 11.73195.54NoNo089
97B:B:C271 B:B:D290 23.56164.67NoYes056
98B:B:C271 B:B:D291 23.19354.67NoNo058
99B:B:D291 B:B:Y289 21.68383.45NoYes1287
100B:B:W297 B:B:Y289 18.32586.75YesYes1287
101B:B:W297 B:B:Y264 17.61635.79YesYes085
102B:B:F335 R:R:H61 16.25465.66YesNo048
103B:B:F335 B:B:R52 14.82335.34YesNo547
104B:B:R52 B:B:T50 14.571810.35NoNo573
105B:B:G162 B:B:Y145 18.70217.24NoYes198
106B:B:G162 B:B:S161 18.47173.71NoNo199
107B:B:H142 B:B:S161 16.723615.34YesNo199
108B:B:H142 B:B:W169 10.03019.52YesYes198
109R:R:V207 R:R:Y211 30.13593.79NoYes059
110R:R:V207 R:R:Y262 29.843712.62NoNo056
111R:R:W265 R:R:Y262 29.29144.82YesNo086
112R:R:W265 R:R:Y200 27.13928.68YesYes885
113R:R:F161 R:R:Y200 22.99539.28YesYes865
114R:R:F161 R:R:S110 11.37959.25YesNo064
115R:R:H174 R:R:S110 11.07454.18YesNo044
116R:R:H174 R:R:V109 17.58979.69YesNo046
117R:R:F105 R:R:V109 16.94333.93NoNo056
118R:R:F105 R:R:P85 15.64945.78NoNo053
119R:R:I294 R:R:K113 13.67264.36NoNo076
120R:R:H174 R:R:I294 11.20355.3YesNo047
121R:R:L254 R:R:T64 12.36145.9NoYes1188
122R:R:L254 R:R:R127 12.37553.64NoYes1189
123R:R:I123 R:R:L254 24.05685.71NoNo098
124R:R:F67 R:R:I123 23.37625.02YesNo089
125R:R:F67 R:R:I150 21.33185.02YesNo088
126R:R:I150 R:R:T70 20.64959.12NoNo089
127R:R:T70 R:R:W154 19.96693.64NoNo099
128R:R:F161 R:R:V111 13.20813.93YesNo065
129R:R:F107 R:R:V111 12.54523.93YesNo065
130R:R:F107 R:R:S164 11.21495.28YesNo065
131R:R:P171 R:R:S164 10.88137.13NoNo035
132R:R:P171 R:R:W185 10.54734.05NoNo037
133R:R:V115 R:R:W154 18.600414.71NoNo079
134R:R:I153 R:R:V115 17.91664.61NoNo067
135R:R:I153 R:R:W118 17.23247.05NoYes064
136A:A:F246 A:A:F273 45.07259.65NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HJ0
Class A
SubFamily Orphan
Type A orphans
SubType GPR21
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtG15)/Beta1/Gamma2
PDB Resolution 3.12
Date 2023-03-15
D.O.I. 10.1038/s41467-023-35882-w
Net Summary
Imin 3.45
Number of Linked Nodes 878
Number of Links 1018
Number of Hubs 147
Number of Links mediated by Hubs 548
Number of Communities 24
Number of Nodes involved in Communities 201
Number of Links involved in Communities 288
Path Summary
Number Of Nodes in MetaPath 137
Number Of Links MetaPath 136
Number of Shortest Paths 893511
Length Of Smallest Path 3
Average Path Length 38.8981
Length of Longest Path 84
Minimum Path Strength 1.275
Average Path Strength 7.42511
Maximum Path Strength 26.92
Minimum Path Correlation 0.7
Average Path Correlation 0.976175
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 38.9414
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.9038
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8HJ0_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LSGGTSGIF ETKFQVDKV NFHMFDVGG QRDERRKWI 
QCFNDVTAI IFVVDSSDY NRLQEALNL FKSIWNNRW LRTISVILF 
LNKQDLLAE KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT 
RAKYFIRDE FLRISTASG DGRHYCYPH FTCAVDTEN ARRIFNDCR 
DSVLARYLD EINLL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HJ0_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HJ0_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99679
Sequence
>8HJ0_Chain_R
VNFCLLEVL IIVFLTVLI ISGNIIVIF VFHCAPLLN HHTTSYFIQ 
TMAYADLFV GVSCVVPSL SLLHHPLPV EESLTCQIF GFVVSVLKS 
VSMWSLACI SIDRYIAIT KPLTYNTLV TPWRLRLCI FLIWLYSTL 
VFLPSFFHW GKPGYHGDV FQWCAESWH TDSYFTLFI VMMLYAPAA 
LIVCFTYFN IFRICQQHT KDISERQAR FSSMVLFRI TSVFYILWL 
PYIIYFLLE SSTGHSNRF ASFLTTWLA ISNSFCNPV IYALSDSTF 
QRGLKRLSG AMCT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HIXAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ0AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ1AOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.272023-12-2710.1038/s41467-023-35882-w
8HJ2AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.82023-03-1510.1038/s41467-023-35882-w
8HMVAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;22.912023-03-0110.1002/mco2.205




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HJ0.zip



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