Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 7.62424
2A:A:K34 5.5975404
3A:A:Y37 8.345404
4A:A:N50 6.8925189
5A:A:K53 6.87254179
6A:A:F219 6.434508
7A:A:F222 11.00254157
8A:A:Q227 8.255419
9A:A:K233 6.905619
10A:A:W234 7.866519
11A:A:F238 11.81254159
12A:A:D249 6.834188
13A:A:Y253 8.055408
14A:A:F273 6.43739
15A:A:W277 10.814536
16A:A:W281 13.61836105
17A:A:F290 4.98667699
18A:A:L291 5.158538
19A:A:K293 5.655409
20A:A:Q294 6.135436
21A:A:L297 3.7425408
22A:A:F312 4.395408
23A:A:F315 13.2775406
24A:A:T320 4.4675431
25A:A:P328 5.5175401
26A:A:K338 7.7025435
27A:A:Y339 6.55533
28A:A:F340 10.5925407
29A:A:R342 7.104534
30A:A:F345 8.346538
31A:A:Y358 7.185474
32A:A:Y360 6.596578
33A:A:F363 8.89535
34A:A:T364 6.225499
35A:A:D368 5.6025499
36A:A:N371 5.564599
37A:A:R374 7.54694
38A:A:L388 3.888578
39B:B:L7 2.575408
40B:B:R22 9446
41B:B:V40 5.0145193
42B:B:L51 6.9875409
43B:B:H54 9.91529
44B:B:K57 13.50754109
45B:B:W63 7.13333607
46B:B:V71 4.1225408
47B:B:D76 7.405409
48B:B:W82 9.75833629
49B:B:T86 8.1825426
50B:B:N88 11.7425427
51B:B:K89 7.044529
52B:B:W99 10.9285159
53B:B:Y105 4.0025406
54B:B:I123 5.02416
55B:B:Y124 6.43833606
56B:B:L139 6.7875409
57B:B:H142 8.74667619
58B:B:Y145 6.855618
59B:B:F151 6.464519
60B:B:L152 4.4725403
61B:B:I157 6.265417
62B:B:T159 5.56619
63B:B:D163 8.192519
64B:B:W169 9.45833618
65B:B:I171 4.46416
66B:B:Q176 6.7175414
67B:B:F180 9.45567
68B:B:H183 9.695669
69B:B:F199 8.27669
70B:B:S201 4.48469
71B:B:D205 6.662569
72B:B:S207 6.6465
73B:B:K209 10.1083666
74B:B:L210 6.655405
75B:B:W211 11.412568
76B:B:Q220 8.7525447
77B:B:F222 8.2775448
78B:B:H225 11.0917649
79B:B:D228 7.28419
80B:B:I229 5.66447
81B:B:I232 5.4775448
82B:B:F234 6.3875405
83B:B:F235 7.8285136
84B:B:P236 7.7854137
85B:B:F241 9.086546
86B:B:T243 6.6575448
87B:B:D247 8.534549
88B:B:R251 9.96857748
89B:B:F253 8.14333646
90B:B:D254 4.5225409
91B:B:D258 8.415647
92B:B:Y264 4.83605
93B:B:F278 6.2765137
94B:B:R283 7.33254199
95B:B:L285 5.12406
96B:B:Y289 6.946676127
97B:B:D290 9.2154106
98B:B:C294 4.7175455
99B:B:N295 9.0754126
100B:B:W297 6.54754128
101B:B:H311 9.594559
102B:B:R314 18.6965108
103B:B:W332 13.40717109
104B:B:F335 7.26454
105B:B:K337 8.932556
106B:B:I338 5.4225425
107B:B:W339 12.005459
108G:G:V16 2.1975407
109G:G:R27 6.032548
110G:G:K32 3.23405
111G:G:Y40 13.744136
112G:G:D48 5.844509
113G:G:N59 6.058529
114G:G:F61 6.47143728
115R:R:C28 1.92404
116R:R:V49 3.695409
117R:R:F53 7.3256147
118R:R:T64 7.4054118
119R:R:F67 5.65254238
120R:R:V78 5.14408
121R:R:L89 4.5025404
122R:R:Q103 7.1775405
123R:R:F107 6.1275406
124R:R:W118 4.8525164
125R:R:D126 7.6054119
126R:R:R127 7.3925119
127R:R:Y128 7.0254248
128R:R:L135 6.715407
129R:R:Y137 6.776676117
130R:R:Y156 4.53754164
131R:R:F161 8.1275486
132R:R:W168 6.4475485
133R:R:H174 6.548504
134R:R:D188 5.8625483
135R:R:F191 6.275485
136R:R:L199 5.67754167
137R:R:Y200 6.65667685
138R:R:Y211 7.015409
139R:R:N213 5.694245
140R:R:I217 4.45476
141R:R:H221 6.125477
142R:R:R231 8.2675436
143R:R:F232 7.748534
144R:R:F261 7.73409
145R:R:W265 6.9588
146R:R:E275 5.9625402
147R:R:Y304 9.4125149
148R:R:F311 7.4925149
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:W82 33.49927.41YesYes299
2B:B:H54 B:B:S74 33.080312.55YesNo299
3B:B:D76 B:B:S74 32.86915.89YesNo099
4B:B:D76 B:B:K78 11.15855.53YesNo098
5B:B:D76 B:B:L55 20.025113.57YesNo096
6A:A:K34 B:B:L55 17.54117.05YesNo046
7A:A:K34 R:R:H61 16.5126.55YesNo048
8B:B:L70 B:B:W82 38.60895.69NoYes059
9B:B:L70 B:B:W63 39.336212.53NoYes057
10B:B:M61 B:B:W63 59.59435.82NoYes067
11B:B:C317 B:B:M61 60.03036.48NoNo076
12B:B:C317 B:B:S316 60.46473.44NoNo079
13B:B:S316 B:B:W332 60.68143.71NoYes099
14A:A:W281 B:B:W332 49.17699.37YesYes1059
15A:A:R280 A:A:W281 55.071617.99NoYes055
16A:A:R280 A:A:R283 55.207110.66NoNo053
17A:A:R283 A:A:R356 55.276212.79NoNo032
18A:A:H357 A:A:R356 55.42534.51NoNo072
19A:A:H357 A:A:W277 55.598732.8NoYes076
20A:A:F273 A:A:W277 54.29164.01YesYes396
21A:A:F273 A:A:F345 96.922310.72YesYes398
22A:A:F345 A:A:L270 91.96088.53YesNo086
23A:A:E344 A:A:L270 92.02543.98NoNo056
24A:A:E344 A:A:F340 92.059211.66NoYes057
25A:A:F315 A:A:F340 94.68313.93YesYes067
26A:A:E309 A:A:F315 99.91819.33NoYes046
27A:A:E309 A:A:K307 99.93095.4NoNo046
28A:A:D310 A:A:K307 99.94348.3NoNo036
29A:A:D310 A:A:Y311 99.95553.45NoNo036
30A:A:N254 A:A:Y311 99.96724.65NoNo096
31A:A:N254 A:A:R265 99.97854.82NoNo099
32A:A:N50 A:A:R265 1008.44YesNo099
33A:A:D249 A:A:N50 99.896610.77YesYes1889
34A:A:D249 A:A:K293 99.5214.15YesYes089
35A:A:K293 A:A:N292 99.69886.99YesNo099
36A:A:I56 A:A:N292 99.72949.91NoNo079
37A:A:I56 A:A:N371 99.72484.25NoYes079
38A:A:F290 A:A:N371 64.61967.25YesYes999
39A:A:F290 A:A:H362 34.53685.66YesNo999
40A:A:D378 A:A:H362 68.895811.35NoNo079
41A:A:D378 A:A:Y360 68.827116.09NoYes078
42A:A:Y358 A:A:Y360 67.93946.95YesYes748
43A:A:Y358 R:R:H221 67.1534.36YesYes747
44A:A:L388 R:R:H221 67.07135.14YesYes787
45A:A:L388 R:R:I217 71.13244.28YesYes786
46R:R:I217 R:R:R216 70.396.26YesNo063
47R:R:N213 R:R:R216 70.12714.82YesNo053
48R:R:N213 R:R:Y128 69.29354.65YesYes2458
49R:R:T210 R:R:Y128 68.8073.75NoYes068
50R:R:S124 R:R:T210 68.54186.4NoNo086
51R:R:S124 R:R:Y211 68.27638.9NoYes089
52R:R:T258 R:R:Y211 36.748111.24NoYes079
53R:R:L120 R:R:T258 36.471810.32NoNo087
54R:R:F261 R:R:L120 33.70744.87YesNo098
55R:R:F261 R:R:N296 33.033615.71YesNo099
56R:R:K113 R:R:N296 32.125.6NoNo069
57R:R:K113 R:R:V78 20.39516.07NoYes068
58R:R:S297 R:R:V78 16.82434.85NoYes098
59R:R:D75 R:R:S297 15.184410.31NoNo099
60R:R:D75 R:R:N46 14.85525.39NoNo099
61R:R:N46 R:R:P301 13.53493.26NoNo099
62R:R:P301 R:R:V49 12.20863.53NoYes099
63A:A:N371 A:A:R374 34.57593.62YesYes994
64A:A:H362 A:A:R374 34.630219.18NoYes994
65A:A:F290 A:A:I245 30.39383.77YesNo997
66A:A:I245 A:A:L43 30.42445.71NoNo077
67A:A:F219 A:A:L43 30.35876.09YesNo087
68A:A:F219 A:A:H41 14.84824.53YesNo086
69A:A:H41 R:R:L135 14.684811.57NoYes067
70A:A:F219 A:A:V217 15.43185.24YesNo085
71A:A:V217 R:R:L135 14.94155.96NoYes057
72B:B:W332 B:B:Y59 20.22137.72YesNo098
73B:B:M101 B:B:Y59 20.36859.58NoNo098
74B:B:M101 B:B:Y145 20.51827.18NoYes098
75A:A:W234 B:B:Y145 47.01026.75YesYes198
76A:A:R231 A:A:W234 47.43447NoYes099
77A:A:L272 A:A:R231 47.48699.72NoNo089
78B:B:M188 B:B:Y145 47.87777.18NoYes188
79A:A:F246 A:A:L272 47.59977.31NoNo098
80A:A:W281 B:B:D290 17.844911.17YesYes1056
81A:A:V383 R:R:L135 32.03814.47NoYes077
82A:A:V383 A:A:Y387 31.71865.05NoNo076
83A:A:Y387 R:R:Y137 31.39886.95NoYes067
84R:R:D126 R:R:Y137 28.16355.75YesYes1197
85R:R:D126 R:R:T64 13.58784.34YesYes1198
86R:R:D126 R:R:R127 14.267213.1YesYes1199
87B:B:M188 B:B:S147 47.95624.6NoNo089
88B:B:S147 B:B:S160 47.72524.89NoNo096
89B:B:S160 B:B:V187 42.25384.85NoNo069
90B:B:H183 B:B:V187 42.01756.92YesNo099
91B:B:H183 B:B:K209 30.205820.96YesYes696
92B:B:K209 B:B:T221 26.014112.01YesNo067
93B:B:T221 G:G:E22 25.7584.23NoNo079
94B:B:D258 G:G:E22 25.50167.8YesNo079
95B:B:I18 G:G:L19 11.88132.85NoNo079
96B:B:L14 G:G:L19 11.31935.54NoNo089
97B:B:C271 B:B:D290 23.62364.67NoYes056
98B:B:C271 B:B:D291 23.25414.67NoNo058
99B:B:D291 B:B:Y289 21.743.45NoYes1287
100B:B:W297 B:B:Y289 18.37076.75YesYes1287
101B:B:W297 B:B:Y264 17.65745.79YesYes085
102B:B:F335 R:R:H61 16.23295.66YesNo048
103B:B:F335 B:B:R52 14.80285.34YesNo547
104B:B:R52 B:B:T50 14.550210.35NoNo573
105B:B:G162 B:B:Y145 18.32247.24NoYes198
106B:B:G162 B:B:S161 18.09563.71NoNo199
107B:B:H142 B:B:S161 16.382915.34YesNo199
108B:B:F180 B:B:T178 10.8379.08YesNo074
109B:B:H183 B:B:S201 10.16855.58YesYes699
110R:R:V207 R:R:Y211 29.96993.79NoYes059
111R:R:V207 R:R:Y262 29.678712.62NoNo056
112R:R:W265 R:R:Y262 29.12734.82YesNo086
113R:R:W265 R:R:Y200 26.98628.68YesYes885
114R:R:F161 R:R:Y200 22.85879.28YesYes865
115R:R:F161 R:R:S110 11.28129.25YesNo064
116R:R:H174 R:R:S110 10.97774.18YesNo044
117R:R:H174 R:R:V109 17.46719.69YesNo046
118R:R:F105 R:R:V109 16.82513.93NoNo056
119R:R:F105 R:R:P85 15.53995.78NoNo053
120R:R:I294 R:R:K113 13.5584.36NoNo076
121R:R:H174 R:R:I294 11.10195.3YesNo047
122R:R:L254 R:R:T64 12.25615.9NoYes1188
123R:R:L254 R:R:R127 12.26973.64NoYes1189
124R:R:I123 R:R:L254 23.85145.71NoNo098
125R:R:F67 R:R:I123 23.17635.02YesNo089
126R:R:F67 R:R:I150 21.14895.02YesNo088
127R:R:I150 R:R:T70 20.47239.12NoNo089
128R:R:T70 R:R:W154 19.79543.64NoNo099
129R:R:F161 R:R:V111 13.10093.93YesNo065
130R:R:F107 R:R:V111 12.4433.93YesNo065
131R:R:F107 R:R:S164 11.12275.28YesNo065
132R:R:P171 R:R:S164 10.79177.13NoNo035
133R:R:P171 R:R:W185 10.46034.05NoNo037
134R:R:V115 R:R:W154 18.440414.71NoNo079
135R:R:I153 R:R:V115 17.76234.61NoNo067
136R:R:I153 R:R:W118 17.08387.05NoYes064
137A:A:F246 A:A:F273 47.78819.65NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HJ0
Class A
SubFamily Orphan
Type Orphan
SubType GPR21
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtG15)/Beta1/Gamma2
PDB Resolution 3.12
Date 2023-03-15
D.O.I. 10.1038/s41467-023-35882-w
Net Summary
Imin 3.44
Number of Linked Nodes 878
Number of Links 1021
Number of Hubs 148
Number of Links mediated by Hubs 549
Number of Communities 24
Number of Nodes involved in Communities 201
Number of Links involved in Communities 289
Path Summary
Number Of Nodes in MetaPath 138
Number Of Links MetaPath 137
Number of Shortest Paths 939374
Length Of Smallest Path 3
Average Path Length 38.721
Length of Longest Path 84
Minimum Path Strength 1.275
Average Path Strength 7.41601
Maximum Path Strength 26.92
Minimum Path Correlation 0.7
Average Path Correlation 0.976393
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 38.9201
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.7981
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • response to peptide hormone   • insulin receptor signaling pathway   • cell surface receptor protein tyrosine kinase signaling pathway   • enzyme-linked receptor protein signaling pathway   • cell surface receptor signaling pathway   • cellular response to peptide hormone stimulus   • response to insulin   • cellular response to insulin stimulus   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • regulation of multicellular organism growth   • regulation of growth   • regulation of developmental growth   • regulation of developmental process   • developmental growth   • growth   • positive regulation of biological process   • positive regulation of multicellular organism growth   • positive regulation of developmental process   • multicellular organism growth   • positive regulation of growth   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of developmental growth   • negative regulation of signaling   • negative regulation of biological process   • regulation of signal transduction   • regulation of cellular response to insulin stimulus   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of signaling   • negative regulation of response to stimulus   • regulation of insulin receptor signaling pathway   • negative regulation of signal transduction   • negative regulation of cellular response to insulin stimulus   • regulation of response to stimulus   • negative regulation of insulin receptor signaling pathway   • regulation of cell communication
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8HJ0_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LSGGTSGIF ETKFQVDKV NFHMFDVGG QRDERRKWI 
QCFNDVTAI IFVVDSSDY NRLQEALNL FKSIWNNRW LRTISVILF 
LNKQDLLAE KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT 
RAKYFIRDE FLRISTASG DGRHYCYPH FTCAVDTEN ARRIFNDCR 
DSVLARYLD EINLL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HJ0_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HJ0_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99679
Sequence
>8HJ0_Chain_R
VNFCLLEVL IIVFLTVLI ISGNIIVIF VFHCAPLLN HHTTSYFIQ 
TMAYADLFV GVSCVVPSL SLLHHPLPV EESLTCQIF GFVVSVLKS 
VSMWSLACI SIDRYIAIT KPLTYNTLV TPWRLRLCI FLIWLYSTL 
VFLPSFFHW GKPGYHGDV FQWCAESWH TDSYFTLFI VMMLYAPAA 
LIVCFTYFN IFRICQQHT KDISERQAR FSSMVLFRI TSVFYILWL 
PYIIYFLLE SSTGHSNRF ASFLTTWLA ISNSFCNPV IYALSDSTF 
QRGLKRLSG AMCT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HJ1AOrphanOrphanGPR21Homo sapiens--Gs/β1/γ23.272023-12-2710.1038/s41467-023-35882-w
8HJ1 (No Gprot) AOrphanOrphanGPR21Homo sapiens--3.272023-12-2710.1038/s41467-023-35882-w
8HJ2AOrphanOrphanGPR21Homo sapiens--chim(Gs-CtG15)/β1/γ23.82023-03-1510.1038/s41467-023-35882-w
8HJ2 (No Gprot) AOrphanOrphanGPR21Homo sapiens--3.82023-03-1510.1038/s41467-023-35882-w
8HJ0AOrphanOrphanGPR21Homo sapiens--chim(Gs-CtG15)/β1/γ23.122023-03-1510.1038/s41467-023-35882-w
8HJ0 (No Gprot) AOrphanOrphanGPR21Homo sapiens--3.122023-03-1510.1038/s41467-023-35882-w
8HIXAOrphanOrphanGPR21Homo sapiens--Gs/β1/γ23.122023-03-1510.1038/s41467-023-35882-w
8HIX (No Gprot) AOrphanOrphanGPR21Homo sapiens--3.122023-03-1510.1038/s41467-023-35882-w
8HMVAOrphanOrphanGPR21Homo sapiens--Gs/β1/γ22.912023-03-0110.1002/mco2.205
8HMV (No Gprot) AOrphanOrphanGPR21Homo sapiens--2.912023-03-0110.1002/mco2.205




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