Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:D33 4.7825405
2A:A:K34 6.6275404
3A:A:Y37 7.0375424
4A:A:K53 5.33409
5A:A:F212 6.52754199
6A:A:F219 7.9225408
7A:A:M221 4.4425198
8A:A:F222 11.24187
9A:A:K233 6.642519
10A:A:W234 7.2825419
11A:A:F238 10.1725409
12A:A:I244 4.7054208
13A:A:Y253 9.665408
14A:A:R265 9.85754219
15A:A:F273 6.156549
16A:A:W277 10.792546
17A:A:W281 11.804515
18A:A:L282 5.9554209
19A:A:K293 6.7075409
20A:A:E309 4.79754244
21A:A:F315 10.295246
22A:A:D323 7.895404
23A:A:T325 3.845402
24A:A:V334 1.965404
25A:A:K338 7.3575445
26A:A:Y339 8.0425403
27A:A:F340 10.2225407
28A:A:R342 8.93404
29A:A:F345 6.36548
30A:A:L346 5.885444
31A:A:Y358 8.02254144
32A:A:C359 4.522545
33A:A:Y360 7.8825148
34A:A:F363 10.9175445
35A:A:F376 5.574228
36A:A:R385 9.384145
37A:A:H387 4.6975498
38A:A:Y391 7.0345124
39B:B:V40 4.6225133
40B:B:H54 9.835429
41B:B:K57 10.5675419
42B:B:Y59 10.766518
43B:B:W63 7.51833607
44B:B:V71 5.21254158
45B:B:D76 6.41429
46B:B:I80 8.8125428
47B:B:W82 12.7525429
48B:B:D83 9.3875428
49B:B:T86 7.2275426
50B:B:K89 7.33571729
51B:B:I93 7.6025407
52B:B:L95 4.8525278
53B:B:W99 9.736509
54B:B:C103 3.4275408
55B:B:Y105 4.4556156
56B:B:L117 4.448519
57B:B:I123 3.5225406
58B:B:Y124 7.76754276
59B:B:H142 7.16667639
60B:B:Y145 5.89125818
61B:B:C149 3.434538
62B:B:F151 6.13409
63B:B:T159 5.274539
64B:B:S161 6.705439
65B:B:D163 7.87539
66B:B:T165 5.775437
67B:B:W169 8.02667638
68B:B:F180 8.7225457
69B:B:H183 8.21559
70B:B:D186 6.435419
71B:B:L190 4.2525455
72B:B:F199 7.196559
73B:B:K209 6.632556
74B:B:W211 7.92858
75B:B:H225 8.7485299
76B:B:D228 6.4825419
77B:B:I232 5.46254108
78B:B:F234 6.454105
79B:B:F235 6.7256166
80B:B:F241 6.498336106
81B:B:T243 6.0625408
82B:B:D247 8.36754299
83B:B:R251 10.925408
84B:B:F253 6.525106
85B:B:D254 3.685409
86B:B:Q259 4.663336256
87B:B:I273 5.81406
88B:B:R283 4.72254139
89B:B:L285 4.195406
90B:B:Y289 7.23254177
91B:B:W297 7.89254178
92B:B:H311 11.3275479
93B:B:R314 17.18518
94B:B:C317 4.3025407
95B:B:T329 6.1675408
96B:B:S331 7.43479
97B:B:W332 12.6233619
98B:B:D333 6.982579
99B:B:F335 6.096504
100B:B:K337 8.328576
101B:B:W339 9.37667679
102G:G:R27 11.03254258
103G:G:Y40 10.58754166
104G:G:H44 4.665406
105G:G:D48 7.545409
106G:G:L51 5.9154136
107R:R:E31 3.9975404
108R:R:T39 3.2225406
109R:R:I42 5.5225408
110R:R:F53 6.86254117
111R:R:Y66 5.894114
112R:R:F67 4.875408
113R:R:L76 3.5325406
114R:R:V78 4.6375408
115R:R:F105 6.3075405
116R:R:M117 4.926587
117R:R:D126 5.9475499
118R:R:Y128 7.9954318
119R:R:P134 3.17408
120R:R:Y137 5.595697
121R:R:F161 6.174566
122R:R:K170 7.285664
123R:R:P171 5.035463
124R:R:Y173 8.418561
125R:R:H174 5.95564
126R:R:F178 3.424504
127R:R:F191 4.5585
128R:R:T192 5.0225404
129R:R:F194 3.975486
130R:R:I195 5.755486
131R:R:Y200 7.84667685
132R:R:Y211 13.06254129
133R:R:F232 6.485404
134R:R:M252 10.065127
135R:R:F261 8.24509
136R:R:W265 5.955488
137R:R:P267 2.8409
138R:R:Y268 5.79506
139R:R:F272 7.975405
140R:R:W291 7.748504
141R:R:F298 5.6975406
142R:R:Y304 7.345409
143R:R:N308 4.846508
144R:R:F311 7.5365119
145R:R:R313 4.1854304
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:K78 18.51296.91YesNo098
2B:B:D76 B:B:S74 26.41254.42YesNo299
3A:A:K34 B:B:L55 1008.46YesNo046
4B:B:D76 B:B:L55 24.34410.86YesNo296
5A:A:K34 A:A:R38 99.52797.43YesNo044
6A:A:R42 A:A:Y37 85.361511.32NoYes094
7A:A:R38 R:R:N138 99.369610.85NoNo044
8A:A:L45 A:A:M221 19.0574.24NoYes088
9A:A:K53 A:A:L45 21.22358.46YesNo098
10A:A:G47 A:A:K53 22.6595.23NoYes099
11A:A:G47 A:A:L46 23.01683.42NoNo098
12A:A:L46 A:A:R231 23.37426.07NoNo089
13A:A:R231 A:A:W234 24.44226NoYes099
14A:A:W234 B:B:L117 14.87624.56YesYes199
15B:B:L117 B:B:W99 40.70874.56YesYes099
16A:A:F222 B:B:W99 21.566121.05YesYes079
17A:A:F222 A:A:R42 21.09244.28YesNo079
18A:A:D240 B:B:W99 23.10254.47NoYes069
19A:A:D240 A:A:R42 65.26599.53NoNo069
20A:A:W234 B:B:Y145 10.0263.86YesYes198
21B:B:M101 B:B:Y145 21.67625.99NoYes198
22B:B:M101 B:B:Y59 21.8193.59NoYes198
23B:B:W332 B:B:Y59 24.946815.43YesYes198
24B:B:C317 B:B:I58 26.25233.27YesNo079
25A:A:F219 A:A:H41 13.52347.92YesNo086
26A:A:H41 R:R:L135 12.02795.14NoNo067
27A:A:K293 A:A:N292 31.40758.39YesNo099
28A:A:N292 A:A:T364 31.69935.85NoNo099
29A:A:F290 A:A:T364 32.5723.89NoNo099
30A:A:F290 A:A:I245 32.83893.77NoNo2397
31A:A:I245 A:A:I288 33.44072.94NoNo079
32A:A:D378 A:A:I288 34.017712.59NoNo079
33A:A:D378 A:A:Y360 34.879810.34NoYes078
34A:A:R385 A:A:Y360 35.89257.2YesYes1458
35A:A:R385 R:R:H221 37.695313.54YesNo057
36A:A:Q384 R:R:H221 94.75938.65NoNo067
37A:A:Q384 R:R:P134 94.934.74NoYes068
38A:A:I383 R:R:P134 96.2793.39NoYes088
39A:A:H387 A:A:I383 96.61186.63YesNo088
40A:A:H387 R:R:Y137 96.85756.53YesYes987
41R:R:N138 R:R:Y137 99.21094.65NoYes047
42A:A:V217 R:R:T136 10.53051.59NoNo054
43A:A:V217 R:R:L135 11.27947.45NoNo057
44B:B:R314 B:B:W332 38.428528.99YesYes189
45A:A:N239 B:B:W332 37.63067.91NoYes089
46A:A:N239 A:A:W281 37.47945.65NoYes085
47A:A:W281 B:B:R314 37.573423.99YesYes158
48B:B:K57 B:B:W332 50.866615.08YesYes199
49A:A:F315 A:A:F340 19.992615YesYes067
50A:A:F315 A:A:I308 23.2986.28YesNo2467
51A:A:I308 A:A:Y253 24.876610.88NoYes078
52A:A:L297 A:A:Y253 26.37963.52NoYes088
53A:A:L297 A:A:S251 26.97784.5NoNo089
54A:A:L296 A:A:S251 27.27626.01NoNo069
55A:A:K293 A:A:L296 28.16885.64YesNo096
56A:A:F340 A:A:Y318 11.014810.32YesNo076
57A:A:R280 A:A:W281 74.887714.99NoYes055
58A:A:R280 B:B:C271 74.18345.57NoNo055
59A:A:L388 R:R:H221 70.40985.14NoNo087
60A:A:L388 R:R:C218 69.50583.17NoNo088
61A:A:L393 R:R:C218 68.82316.35NoNo088
62A:A:L393 A:A:Y391 65.20728.21NoYes1284
63A:A:Y391 R:R:R127 64.69356.17YesNo049
64R:R:N308 R:R:V253 11.17375.91YesNo088
65R:R:R127 R:R:V253 11.49463.92NoNo098
66B:B:C271 B:B:D291 73.83314.67NoNo058
67B:B:D291 B:B:Y289 72.47268.05NoYes087
68B:B:I273 B:B:Y289 52.43729.67YesYes067
69B:B:G244 B:B:I273 42.62217.05NoYes056
70B:B:G244 B:B:T243 42.23073.64NoYes058
71B:B:F253 B:B:T243 23.63883.89YesYes068
72B:B:F222 B:B:F253 13.780310.72NoYes1086
73B:B:F222 B:B:Q220 13.51817.03NoNo087
74B:B:C317 B:B:G330 17.99733.92YesNo075
75B:B:G330 B:B:S331 17.80463.71NoYes059
76B:B:H311 B:B:S331 15.247416.74YesYes799
77B:B:V327 B:B:W339 15.01573.68NoYes069
78B:B:V320 B:B:V327 14.69123.21NoNo076
79B:B:S277 B:B:V320 14.36854.85NoNo057
80B:B:C233 B:B:S277 14.0473.44NoNo035
81B:B:C233 B:B:F278 13.72896.98NoNo037
82B:B:F235 B:B:F278 29.04818.57YesNo067
83B:B:F235 G:G:L37 13.35558.53YesNo067
84B:B:L300 G:G:L37 19.4284.15NoNo067
85B:B:C250 B:B:I273 11.81473.27NoYes086
86B:B:C250 B:B:Y264 11.41714.03NoNo085
87B:B:S147 B:B:Y145 17.15776.36NoYes098
88B:B:S147 B:B:S160 16.81053.26NoNo096
89B:B:L190 B:B:S160 10.4064.5YesNo056
90B:B:G162 B:B:Y145 12.88878.69NoYes098
91B:B:G162 B:B:S161 12.53043.71NoYes099
92B:B:K78 B:B:P94 16.82338.36NoNo085
93B:B:I232 B:B:T243 15.34839.12YesYes088
94B:B:F234 B:B:F241 13.44533.22YesYes1056
95B:B:A193 B:B:F234 17.58484.16NoYes045
96B:B:A193 B:B:D195 13.82323.09NoNo045
97B:B:D195 B:B:R197 12.56843.57NoNo055
98B:B:D212 B:B:R197 10.057513.1NoNo095
99B:B:W297 B:B:Y289 21.08097.72YesYes1787
100B:B:L285 B:B:W297 19.19453.42YesYes068
101R:R:L254 R:R:R127 55.89768.5NoNo089
102R:R:L254 R:R:S124 55.64516.01NoNo088
103R:R:S124 R:R:V207 53.60926.46NoNo085
104R:R:V207 R:R:Y262 52.17026.31NoNo056
105R:R:F261 R:R:Y262 51.65597.22YesNo096
106R:R:F261 R:R:M117 47.13593.73YesYes097
107R:R:M117 R:R:W265 34.664.65YesYes878
108R:R:W265 R:R:Y268 34.40535.79YesYes086
109R:R:T290 R:R:Y268 19.3113.75NoYes056
110R:R:T290 R:R:W291 18.99654.85NoYes054
111R:R:F272 R:R:Y268 10.734912.38YesYes056
112B:B:I93 B:B:P94 16.48523.39YesNo075
113B:B:L117 B:B:Y145 22.46063.52YesYes198
114A:A:D240 B:B:K57 48.19058.3NoYes069
115B:B:I58 B:B:S74 22.06534.64NoNo299
116A:A:Y37 B:B:L55 75.81239.38YesNo246
117B:B:F278 B:B:L285 17.7067.31NoYes076
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HJ1
Class A
SubFamily Orphan
Type A orphans
SubType GPR21
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.27
Date 2023-12-27
D.O.I. 10.1038/s41467-023-35882-w
Net Summary
Imin 3.17
Number of Linked Nodes 877
Number of Links 1002
Number of Hubs 145
Number of Links mediated by Hubs 540
Number of Communities 31
Number of Nodes involved in Communities 187
Number of Links involved in Communities 243
Path Summary
Number Of Nodes in MetaPath 118
Number Of Links MetaPath 117
Number of Shortest Paths 835472
Length Of Smallest Path 3
Average Path Length 30.2756
Length of Longest Path 63
Minimum Path Strength 1.21
Average Path Strength 7.1425
Maximum Path Strength 26.49
Minimum Path Correlation 0.7
Average Path Correlation 0.974933
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 46.2576
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.5215
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8HJ1_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LSGGTSGIF ETKFQVDKV NFHMFDVGG QRDERRKWI 
QCFNDVTAI IFVVDSSDY NRLQEALNL FKSIWNNRW LRTISVILF 
LNKQDLLAE KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT 
RAKYFIRDE FLRISTASG DGRHYCYPH FTCAVDTEN ARRIFNDCR 
DIIQRMHLR QYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HJ1_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HJ1_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99679
Sequence
>8HJ1_Chain_R
NFCLLEVLI IVFLTVLII SGNIIVIFV FHCAPLLNH HTTSYFIQT 
MAYADLFVG VSCVVPSLS LLHHPLPVE ESLTCQIFG FVVSVLKSV 
SMASLACIS IDRYIAITK PLTYNTLVT PWRLRLCIF LIWLYSTLV 
FLPSFFHWG KPGYHGDVF QWCAESWHT DSYFTLFIV MMLYAPAAL 
IVCFTYFNI FRICQQHTK DISERQARF SSAMVLFRI TSVFYILWL 
PYIIYFLLE SSTGHSNRF ASFLTTWLA ISNSFCNCV IYSLSNSVF 
QRGLKRLSG AMCT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HIXAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ0AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ1AOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.272023-12-2710.1038/s41467-023-35882-w
8HJ2AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.82023-03-1510.1038/s41467-023-35882-w
8HMVAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;22.912023-03-0110.1002/mco2.205




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HJ1.zip



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