psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C28	R:R:V25	6.83	No	No	0	4	3
2	R:R:E31	R:R:R283	11.63	No	No	6	4	3
3	R:R:E31	R:R:F287	16.32	No	Yes	6	4	5
4	R:R:L89	R:R:V32	5.96	No	Yes	0	4	4
5	R:R:L90	R:R:V32	7.45	No	Yes	0	5	4
6	R:R:F287	R:R:I34	5.02	Yes	No	0	5	5
7	R:R:I35	R:R:S86	4.64	No	No	0	6	7
8	R:R:I35	R:R:W291	9.4	No	Yes	0	6	4
9	R:R:F37	R:R:L41	6.09	No	No	0	4	4
10	R:R:L38	R:R:W291	4.56	No	Yes	0	7	4
11	R:R:C82	R:R:T39	3.38	No	No	0	7	6
12	R:R:F298	R:R:L41	10.96	No	No	0	6	4
13	R:R:I42	R:R:S297	6.19	No	Yes	0	8	9
14	R:R:F298	R:R:I42	5.02	No	No	0	6	8
15	R:R:G45	R:R:P301	4.06	No	No	0	8	9
16	R:R:D75	R:R:N46	6.73	No	No	0	9	9
17	R:R:N46	R:R:P301	4.89	No	No	0	9	9
18	R:R:I47	R:R:L76	4.28	No	No	0	5	6
19	R:R:A72	R:R:V49	3.39	No	No	0	9	9
20	R:R:P301	R:R:V49	3.53	No	No	0	9	9
21	R:R:A72	R:R:I50	3.25	No	No	0	9	7
22	R:R:I50	R:R:Y73	20.55	No	No	0	7	6
23	R:R:C55	R:R:F51	8.38	No	No	0	5	4
24	R:R:F51	R:R:M322	3.73	No	No	0	4	3
25	R:R:F311	R:R:V52	3.93	Yes	No	0	9	8
26	R:R:L318	R:R:V52	4.47	No	No	0	6	8
27	R:R:F53	R:R:L59	3.65	Yes	Yes	0	7	9
28	R:R:F53	R:R:S65	6.61	Yes	No	1	7	9
29	R:R:F53	R:R:I68	6.28	Yes	No	0	7	8
30	R:R:F53	R:R:Q69	8.2	Yes	No	1	7	6
31	R:R:F311	R:R:F53	6.43	Yes	Yes	1	9	7
32	R:R:L58	R:R:L59	4.15	No	Yes	0	5	9
33	R:R:H62	R:R:L59	5.14	No	Yes	0	7	9
34	R:R:H61	R:R:N60	14.03	No	No	0	8	5
35	R:R:H61	R:R:Y66	4.36	No	No	0	8	4
36	R:R:H62	R:R:S65	4.18	No	No	0	7	9
37	R:R:D126	R:R:T63	4.34	Yes	No	5	9	5
38	R:R:T63	R:R:Y137	11.24	No	Yes	5	5	7
39	R:R:T63	R:R:V141	4.76	No	No	5	5	6
40	R:R:D126	R:R:T64	5.78	Yes	No	0	9	8
41	R:R:R127	R:R:T64	12.94	No	No	0	9	8
42	R:R:Q69	R:R:S65	4.33	No	No	1	6	9
43	R:R:L146	R:R:Y66	7.03	No	No	0	7	4
44	R:R:R147	R:R:Y66	10.29	No	No	0	1	4
45	R:R:C122	R:R:F67	11.17	No	Yes	8	7	8
46	R:R:F67	R:R:I123	5.02	Yes	No	0	8	9
47	R:R:C149	R:R:F67	5.59	No	Yes	8	6	8
48	R:R:F67	R:R:I150	6.28	Yes	No	0	8	8
49	R:R:I150	R:R:T70	12.16	No	No	0	8	9
50	R:R:M71	R:R:S119	6.13	No	No	0	9	8
51	R:R:L120	R:R:M71	7.07	No	No	0	8	9
52	R:R:M71	R:R:N300	4.21	No	No	0	9	9
53	R:R:A74	R:R:V115	3.39	No	No	0	8	7
54	R:R:D75	R:R:S116	4.42	No	No	0	9	9
55	R:R:D75	R:R:S297	10.31	No	Yes	0	9	9
56	R:R:F77	R:R:L112	6.09	No	No	0	7	6
57	R:R:V109	R:R:V78	4.81	No	No	0	6	8
58	R:R:L112	R:R:V78	4.47	No	No	0	6	8
59	R:R:S297	R:R:V78	6.46	Yes	No	0	9	8
60	R:R:S81	R:R:V108	4.85	No	No	0	5	4
61	R:R:P85	R:R:V84	3.53	No	No	0	3	8
62	R:R:F105	R:R:P85	7.22	Yes	No	0	5	3
63	R:R:L87	R:R:P93	3.28	No	No	0	5	4
64	R:R:F178	R:R:S88	6.61	Yes	No	0	4	5
65	R:R:L89	R:R:V177	5.96	No	No	0	4	2
66	R:R:L94	R:R:P95	4.93	No	No	0	4	7
67	R:R:E98	R:R:L94	11.93	No	No	0	7	4
68	R:R:P95	R:R:T101	3.5	No	No	0	7	5
69	R:R:E97	R:R:L100	6.63	No	No	0	5	1
70	R:R:S99	R:R:W180	11.12	No	No	0	3	3
71	R:R:F178	R:R:T101	3.89	Yes	No	0	4	5
72	R:R:C102	R:R:F178	4.19	No	Yes	0	9	4
73	R:R:C102	R:R:C181	7.28	No	No	0	9	9
74	R:R:Q103	R:R:W185	5.48	No	Yes	0	5	7
75	R:R:F105	R:R:V109	5.24	Yes	No	0	5	6
76	R:R:F105	R:R:F178	5.36	Yes	Yes	9	5	4
77	R:R:F107	R:R:V111	7.87	No	No	0	6	5
78	R:R:F107	R:R:F165	12.86	No	No	0	6	5
79	R:R:H174	R:R:V109	4.15	Yes	No	0	4	6
80	R:R:F161	R:R:S110	11.89	Yes	No	0	6	4
81	R:R:H174	R:R:S110	5.58	Yes	No	0	4	4
82	R:R:F161	R:R:V111	6.55	Yes	No	0	6	5
83	R:R:I294	R:R:K113	4.36	No	No	0	7	6
84	R:R:K113	R:R:N296	8.39	No	No	0	6	9
85	R:R:K113	R:R:S297	6.12	No	Yes	0	6	9
86	R:R:S114	R:R:S157	6.52	No	No	0	6	8
87	R:R:L199	R:R:S114	9.01	Yes	No	0	7	6
88	R:R:V115	R:R:W154	23.29	No	No	0	7	9
89	R:R:S157	R:R:V115	3.23	No	No	0	8	7
90	R:R:F261	R:R:S116	6.61	Yes	No	0	9	9
91	R:R:M117	R:R:Y200	4.79	No	Yes	3	7	5
92	R:R:F261	R:R:M117	3.73	Yes	No	0	9	7
93	R:R:M117	R:R:W265	6.98	No	Yes	3	7	8
94	R:R:I153	R:R:W118	7.05	No	Yes	0	6	4
95	R:R:W118	R:R:Y156	3.86	Yes	No	0	4	4
96	R:R:L199	R:R:W118	3.42	Yes	Yes	0	7	4
97	R:R:P202	R:R:W118	5.4	No	Yes	0	9	4
98	R:R:A203	R:R:W118	3.89	No	Yes	0	6	4
99	R:R:L120	R:R:T258	4.42	No	No	0	8	7
100	R:R:F261	R:R:L120	6.09	Yes	No	0	9	8
101	R:R:A121	R:R:I206	3.25	No	No	0	7	8
102	R:R:C122	R:R:C149	3.64	No	No	8	7	6
103	R:R:C122	R:R:I153	3.27	No	No	0	7	6
104	R:R:I123	R:R:L254	5.71	No	No	0	9	8
105	R:R:S124	R:R:V207	6.46	No	No	0	8	5
106	R:R:S124	R:R:T210	4.8	No	No	0	8	6
107	R:R:S124	R:R:Y211	3.82	No	Yes	0	8	9
108	R:R:D126	R:R:Y137	5.75	Yes	Yes	5	9	7
109	R:R:D126	R:R:V141	4.38	Yes	No	5	9	6
110	R:R:L254	R:R:R127	4.86	No	No	0	8	9
111	R:R:T132	R:R:Y128	16.23	No	Yes	0	6	8
112	R:R:F209	R:R:Y128	7.22	No	Yes	4	4	8
113	R:R:T210	R:R:Y128	7.49	No	Yes	0	6	8
114	R:R:N213	R:R:Y128	8.14	Yes	Yes	4	5	8
115	R:R:A130	R:R:Y137	9.34	No	Yes	0	8	7
116	R:R:I131	R:R:I214	5.89	No	No	0	9	9
117	R:R:I131	R:R:I217	5.89	No	No	0	9	6
118	R:R:V141	R:R:Y137	5.05	No	Yes	5	6	7
119	R:R:P143	R:R:T142	5.25	No	No	0	3	8
120	R:R:R145	R:R:T142	5.17	No	No	0	5	8
121	R:R:L148	R:R:L152	5.54	No	No	0	2	3
122	R:R:L155	R:R:L159	8.3	No	No	0	3	3
123	R:R:V160	R:R:Y156	8.83	No	No	0	5	4
124	R:R:M198	R:R:Y156	4.79	No	No	0	6	4
125	R:R:L199	R:R:V160	5.96	Yes	No	0	7	5
126	R:R:F161	R:R:P171	4.33	Yes	Yes	0	6	3
127	R:R:F161	R:R:L199	3.65	Yes	Yes	0	6	7
128	R:R:F191	R:R:P163	7.22	No	No	0	5	5
129	R:R:P171	R:R:S164	8.91	Yes	No	0	3	5
130	R:R:F191	R:R:G169	4.52	No	No	0	5	5
131	R:R:K170	R:R:P171	3.35	Yes	Yes	2	4	3
132	R:R:K170	R:R:Y173	5.97	Yes	Yes	2	4	1
133	R:R:D176	R:R:K170	5.53	No	Yes	2	4	4
134	R:R:K170	R:R:W185	18.57	Yes	Yes	2	4	7
135	R:R:K170	R:R:T187	4.5	Yes	No	2	4	5
136	R:R:P171	R:R:W185	5.4	Yes	Yes	2	3	7
137	R:R:F272	R:R:G172	4.52	Yes	No	0	5	1
138	R:R:D176	R:R:Y173	10.34	No	Yes	2	4	1
139	R:R:T187	R:R:Y173	8.74	No	Yes	2	5	1
140	R:R:F272	R:R:Y173	6.19	Yes	Yes	0	5	1
141	R:R:E275	R:R:Y173	7.86	Yes	Yes	0	2	1
142	R:R:H174	R:R:Y268	8.71	Yes	Yes	0	4	6
143	R:R:H174	R:R:I294	5.3	Yes	No	0	4	7
144	R:R:A182	R:R:D176	6.18	No	No	0	3	4
145	R:R:S184	R:R:W180	19.77	No	No	0	3	3
146	R:R:C181	R:R:W185	3.92	No	Yes	0	9	7
147	R:R:S276	R:R:T187	6.4	No	No	0	3	5
148	R:R:D188	R:R:Y190	9.2	No	No	0	3	7
149	R:R:F191	R:R:I195	3.77	No	No	0	5	6
150	R:R:F272	R:R:T192	10.38	Yes	No	0	5	4
151	R:R:S276	R:R:T192	9.59	No	No	0	3	4
152	R:R:F194	R:R:I195	3.77	No	No	0	6	6
153	R:R:F194	R:R:M198	6.22	No	No	0	6	6
154	R:R:I195	R:R:Y200	8.46	No	Yes	0	6	5
155	R:R:V196	R:R:Y200	8.83	No	Yes	0	5	5
156	R:R:L199	R:R:Y200	4.69	Yes	Yes	0	7	5
157	R:R:W265	R:R:Y200	6.75	Yes	Yes	3	8	5
158	R:R:I269	R:R:Y200	6.04	No	Yes	3	7	5
159	R:R:V207	R:R:Y262	6.31	No	No	0	5	6
160	R:R:F209	R:R:N213	9.67	No	Yes	4	4	5
161	R:R:L254	R:R:Y211	4.69	No	Yes	0	8	9
162	R:R:F255	R:R:Y211	7.22	No	Yes	0	5	9
163	R:R:T258	R:R:Y211	8.74	No	Yes	0	7	9
164	R:R:F212	R:R:N213	4.83	No	Yes	4	3	5
165	R:R:F212	R:R:R216	6.41	No	No	4	3	3
166	R:R:N213	R:R:R216	3.62	Yes	No	4	5	3
167	R:R:F215	R:R:M252	8.71	No	No	10	6	7
168	R:R:F215	R:R:F255	8.57	No	No	10	6	5
169	R:R:F255	R:R:M252	17.42	No	No	10	5	7
170	R:R:M252	R:R:R256	3.72	No	No	0	7	6
171	R:R:V253	R:R:Y304	5.05	No	Yes	1	8	9
172	R:R:D308	R:R:V253	10.22	Yes	No	1	8	8
173	R:R:R256	R:R:S307	3.95	No	No	0	6	7
174	R:R:I257	R:R:Y304	3.63	No	Yes	0	8	9
175	R:R:S259	R:R:V260	3.23	No	No	0	4	6
176	R:R:F261	R:R:N296	18.12	Yes	No	0	9	9
177	R:R:F261	R:R:N300	7.25	Yes	No	0	9	9
178	R:R:W265	R:R:Y268	7.72	Yes	Yes	3	8	6
179	R:R:I269	R:R:W265	9.4	No	Yes	3	7	8
180	R:R:L292	R:R:P267	3.28	No	No	0	6	9
181	R:R:I269	R:R:Y268	3.63	No	Yes	3	7	6
182	R:R:F272	R:R:Y268	9.28	Yes	Yes	0	5	6
183	R:R:A293	R:R:Y268	4	No	Yes	0	7	6
184	R:R:T289	R:R:Y271	6.24	No	No	0	5	5
185	R:R:E275	R:R:S281	5.75	Yes	No	0	2	3
186	R:R:E275	R:R:S286	8.62	Yes	No	0	2	4
187	R:R:F284	R:R:R283	4.28	No	No	0	1	3
188	R:R:F287	R:R:R283	7.48	Yes	No	6	5	3
189	R:R:F287	R:R:W291	16.04	Yes	Yes	0	5	4
190	R:R:T290	R:R:W291	3.64	No	Yes	0	5	4
191	R:R:I294	R:R:W291	7.05	No	Yes	0	7	4
192	R:R:L292	R:R:S295	4.5	No	No	0	6	6
193	R:R:C299	R:R:F298	4.19	No	No	0	5	6
194	R:R:I303	R:R:S307	4.64	No	No	0	8	7
195	R:R:D308	R:R:Y304	4.6	Yes	Yes	1	8	9
196	R:R:F311	R:R:Y304	22.69	Yes	Yes	1	9	9
197	R:R:D308	R:R:T310	4.34	Yes	No	0	8	6
198	R:R:D308	R:R:F311	3.58	Yes	Yes	1	8	9
199	R:R:L315	R:R:Q312	5.32	No	No	0	6	9
200	R:R:K316	R:R:Q312	10.85	No	No	0	5	9
201	R:R:T158	R:R:V111	3.17	No	No	0	3	5
202	R:R:M197	R:R:V196	3.04	No	No	0	4	5
203	R:R:F105	R:R:G106	3.01	Yes	No	0	5	4
204	R:R:F105	R:R:G175	3.01	Yes	No	9	5	3
205	R:R:F178	R:R:G175	3.01	Yes	No	9	4	3
206	R:R:K133	R:R:T132	3	Yes	No	0	5	6
207	R:R:K133	R:R:T136	3	Yes	No	0	5	4
208	R:R:L264	R:R:S295	3	No	No	0	8	6
209	R:R:L273	R:R:S277	3	No	No	0	6	4
210	R:R:L41	R:R:V40	2.98	No	No	0	4	5
211	R:R:L87	R:R:V84	2.98	No	No	0	5	8
212	R:R:L306	R:R:V302	2.98	No	No	0	5	6
213	R:R:L140	R:R:T136	2.95	No	No	0	4	4
214	R:R:I123	R:R:I68	2.94	No	No	0	9	8
215	R:R:I125	R:R:I129	2.94	No	No	0	6	5
216	R:R:I125	R:R:I206	2.94	No	No	0	6	8
217	R:R:I129	R:R:K133	2.91	No	Yes	0	5	5
218	R:R:P143	R:R:R147	2.88	No	No	0	3	1
219	R:R:E31	R:R:V177	2.85	No	No	0	4	2
220	R:R:I43	R:R:L76	2.85	No	No	0	6	6
221	R:R:I50	R:R:L76	2.85	No	No	0	7	6
222	R:R:I104	R:R:L100	2.85	No	No	0	4	1
223	R:R:L193	R:R:M197	2.83	No	No	0	4	4
224	R:R:C82	R:R:F105	2.79	No	Yes	0	7	5
225	R:R:L29	R:R:L33	2.77	No	No	7	4	5
226	R:R:A305	R:R:F311	2.77	No	Yes	0	7	9
227	R:R:A204	R:R:Y262	2.67	No	No	0	3	6
228	R:R:A285	R:R:Y271	2.67	No	No	0	4	5
229	R:R:L100	R:R:Q103	2.66	No	No	0	1	5
230	R:R:F105	R:R:S81	2.64	Yes	No	0	5	5
231	R:R:F77	R:R:V80	2.62	No	No	0	7	4
232	R:R:C181	R:R:W180	2.61	No	No	0	9	3
233	R:R:F67	R:R:L146	2.44	Yes	No	0	8	7
234	R:R:F151	R:R:L155	2.44	No	No	0	4	3
235	R:R:I214	R:R:Y211	2.42	No	Yes	0	9	9
236	R:R:F27	R:R:F284	2.14	No	No	0	1	1
237	R:R:F232	R:R:R231	2.14	No	No	0	4	6
238	R:R:C82	R:R:G79	1.96	No	No	0	7	7
239	R:R:A56	R:R:P57	1.87	No	No	0	5	6
240	R:R:A201	R:R:P202	1.87	No	No	0	4	9
241	R:R:G45	R:R:S44	1.86	No	No	0	8	4
242	R:R:G45	R:R:I48	1.76	No	No	0	8	7
243	R:R:P267	R:R:T289	1.75	No	No	0	9	5
244	R:R:C323	R:R:S319	1.72	No	No	0	5	4
245	R:R:C218	R:R:T222	1.69	No	No	0	8	5
246	R:R:D188	R:R:G169	1.68	No	No	0	3	5
247	R:R:K133	R:R:P134	1.67	Yes	No	0	5	8
248	R:R:L162	R:R:P163	1.64	No	No	0	4	5
249	R:R:L266	R:R:P267	1.64	No	No	0	6	9
250	R:R:S189	R:R:S276	1.63	No	No	0	4	3
251	R:R:S233	R:R:S234	1.63	No	No	0	2	4
252	R:R:S86	R:R:V36	1.62	No	No	0	7	4
253	R:R:V83	R:R:V84	1.6	No	No	0	7	8
254	R:R:S277	R:R:T278	1.6	No	No	0	4	4
255	R:R:S309	R:R:T310	1.6	No	No	0	4	6
256	R:R:C55	R:R:L318	1.59	No	No	0	5	6
257	R:R:C299	R:R:L264	1.59	No	No	0	5	8
258	R:R:A56	R:R:L59	1.58	No	Yes	0	5	9
259	R:R:A305	R:R:L306	1.58	No	No	0	7	5
260	R:R:A305	R:R:L315	1.58	No	No	0	7	6
261	R:R:T136	R:R:T139	1.57	No	No	0	4	4
262	R:R:A285	R:R:N282	1.56	No	No	0	4	4
263	R:R:I303	R:R:V260	1.54	No	No	0	8	6
264	R:R:A182	R:R:E183	1.51	No	No	0	3	5
265	R:R:G314	R:R:R317	1.5	No	No	0	7	4
266	R:R:L29	R:R:V32	1.49	No	Yes	7	4	4
267	R:R:L33	R:R:V32	1.49	No	Yes	7	5	4
268	R:R:C55	R:R:H54	1.47	No	No	0	5	3
269	R:R:L273	R:R:T192	1.47	No	No	0	6	4
270	R:R:L288	R:R:T289	1.47	No	No	0	4	5
271	R:R:I34	R:R:L30	1.43	No	No	0	5	5
272	R:R:E97	R:R:V96	1.43	No	No	0	5	3
273	R:R:I263	R:R:L264	1.43	No	No	0	5	8
274	R:R:L159	R:R:L162	1.38	No	No	0	3	4
275	R:R:I225	R:R:Q229	1.37	No	No	0	6	3
276	R:R:P163	R:R:W168	1.35	No	No	0	5	5
277	R:R:E227	R:R:K223	1.35	No	No	0	3	4
278	R:R:H221	R:R:I217	1.33	No	No	0	7	6
279	R:R:E275	R:R:L274	1.33	Yes	No	0	2	4
280	R:R:H91	R:R:L90	1.29	No	No	0	4	5
281	R:R:H92	R:R:L94	1.29	No	No	0	4	4
282	R:R:R313	R:R:T310	1.29	No	No	0	4	6
283	R:R:E183	R:R:Q179	1.27	No	No	0	5	4
284	R:R:F151	R:R:L148	1.22	No	No	0	4	2
285	R:R:T142	R:R:W144	1.21	No	No	0	8	4
286	R:R:I270	R:R:Y271	1.21	No	No	0	7	5
287	R:R:N138	R:R:Y137	1.16	No	Yes	0	4	7
288	R:R:R313	R:R:R317	1.07	No	No	0	4	4
289	R:R:F166	R:R:W168	1	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V32	4.0975	4	7	4
2	R:R:F53	6.234	5	1	7
3	R:R:L59	3.63	4	0	9
4	R:R:F67	6.1	5	8	8
5	R:R:F105	4.18143	7	9	5
6	R:R:W118	4.724	5	0	4
7	R:R:D126	5.0625	4	5	9
8	R:R:Y128	9.77	4	4	8
9	R:R:K133	2.645	4	0	5
10	R:R:Y137	6.508	5	5	7
11	R:R:F161	6.605	4	0	6
12	R:R:K170	7.584	5	2	4
13	R:R:P171	5.4975	4	2	3
14	R:R:Y173	7.82	5	2	1
15	R:R:H174	5.935	4	0	4
16	R:R:F178	4.612	5	9	4
17	R:R:W185	8.3425	4	2	7
18	R:R:L199	5.346	5	0	7
19	R:R:Y200	6.59333	6	3	5
20	R:R:Y211	5.378	5	0	9
21	R:R:N213	6.565	4	4	5
22	R:R:F261	8.36	5	0	9
23	R:R:W265	7.7125	4	3	8
24	R:R:Y268	6.668	5	3	6
25	R:R:F272	7.5925	4	0	5
26	R:R:E275	5.89	4	0	2
27	R:R:F287	11.215	4	6	5
28	R:R:W291	8.138	5	0	4
29	R:R:S297	7.27	4	0	9
30	R:R:Y304	8.9925	4	1	9
31	R:R:D308	5.685	4	1	8
32	R:R:F311	7.88	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E31	R:R:V177	13.1013	2.85	No	No	0	4	2
2	R:R:L89	R:R:V177	11.2684	5.96	No	No	0	4	2
3	R:R:E31	R:R:F287	14.7621	16.32	No	Yes	6	4	5
4	R:R:F287	R:R:W291	25.5608	16.04	Yes	Yes	0	5	4
5	R:R:I294	R:R:W291	35.7242	7.05	No	Yes	0	7	4
6	R:R:I294	R:R:K113	36.2999	4.36	No	No	0	7	6
7	R:R:K113	R:R:S297	42.5131	6.12	No	Yes	0	6	9
8	R:R:I42	R:R:S297	54.066	6.19	No	Yes	0	8	9
9	R:R:F298	R:R:I42	51.1745	5.02	No	No	0	6	8
10	R:R:F105	R:R:V109	56.7723	5.24	Yes	No	0	5	6
11	R:R:H174	R:R:V109	50.2217	4.15	Yes	No	0	4	6
12	R:R:H174	R:R:I294	38.8937	5.3	Yes	No	0	4	7
13	R:R:D75	R:R:S297	40.0053	10.31	No	Yes	0	9	9
14	R:R:D75	R:R:N46	25.9578	6.73	No	No	0	9	9
15	R:R:N46	R:R:P301	23.8669	4.89	No	No	0	9	9
16	R:R:P301	R:R:V49	15.3709	3.53	No	No	0	9	9
17	R:R:A72	R:R:V49	13.2138	3.39	No	No	0	9	9
18	R:R:A72	R:R:I50	11.0435	3.25	No	No	0	9	7
19	R:R:F311	R:R:V52	11.7846	3.93	Yes	No	0	9	8
20	R:R:F311	R:R:F53	42.6057	6.43	Yes	Yes	1	9	7
21	R:R:F53	R:R:I68	57.3744	6.28	Yes	No	0	7	8
22	R:R:I123	R:R:I68	58.9492	2.94	No	No	0	9	8
23	R:R:I123	R:R:L254	45.0804	5.71	No	No	0	9	8
24	R:R:L254	R:R:Y211	54.7873	4.69	No	Yes	0	8	9
25	R:R:T258	R:R:Y211	96.2218	8.74	No	Yes	0	7	9
26	R:R:L120	R:R:T258	97.3334	4.42	No	No	0	8	7
27	R:R:F261	R:R:L120	100	6.09	Yes	No	0	9	8
28	R:R:F261	R:R:N296	48.3623	18.12	Yes	No	0	9	9
29	R:R:K113	R:R:N296	48.1043	8.39	No	No	0	6	9
30	R:R:H174	R:R:S110	30.1198	5.58	Yes	No	0	4	4
31	R:R:F161	R:R:S110	29.7691	11.89	Yes	No	0	6	4
32	R:R:F161	R:R:L199	46.7214	3.65	Yes	Yes	0	6	7
33	R:R:L199	R:R:W118	48.2697	3.42	Yes	Yes	0	7	4
34	R:R:I153	R:R:W118	44.4981	7.05	No	Yes	0	6	4
35	R:R:C122	R:R:I153	43.5254	3.27	No	No	0	7	6
36	R:R:C122	R:R:F67	41.0375	11.17	No	Yes	8	7	8
37	R:R:F67	R:R:L146	16.7273	2.44	Yes	No	0	8	7
38	R:R:L146	R:R:Y66	14.9209	7.03	No	No	0	7	4
39	R:R:D126	R:R:T64	13.6505	5.78	Yes	No	0	9	8
40	R:R:R127	R:R:T64	15.8804	12.94	No	No	0	9	8
41	R:R:L254	R:R:R127	18.097	4.86	No	No	0	8	9
42	R:R:L199	R:R:S114	10.7788	9.01	Yes	No	0	7	6
43	R:R:F261	R:R:S116	42.6653	6.61	Yes	No	0	9	9
44	R:R:D75	R:R:S116	41.8977	4.42	No	No	0	9	9
45	R:R:S297	R:R:V78	37.8151	6.46	Yes	No	0	9	8
46	R:R:V109	R:R:V78	36.1477	4.81	No	No	0	6	8
47	R:R:F105	R:R:P85	14.3188	7.22	Yes	No	0	5	3
48	R:R:P85	R:R:V84	11.4802	3.53	No	No	0	3	8
49	R:R:F105	R:R:F178	24.5947	5.36	Yes	Yes	9	5	4
50	R:R:F178	R:R:T101	16.37	3.89	Yes	No	0	4	5
51	R:R:P95	R:R:T101	13.1212	3.5	No	No	0	7	5
52	R:R:F161	R:R:P171	30.3844	4.33	Yes	Yes	0	6	3
53	R:R:P171	R:R:W185	18.8646	5.4	Yes	Yes	2	3	7
54	R:R:Q103	R:R:W185	11.3081	5.48	No	Yes	0	5	7
55	R:R:C102	R:R:F178	10.7788	4.19	No	Yes	0	9	4
56	R:R:C102	R:R:C181	10.2561	7.28	No	No	0	9	9
57	R:R:C181	R:R:W185	13.3792	3.92	No	Yes	0	9	7
58	R:R:F261	R:R:M117	50.0232	3.73	Yes	No	0	9	7
59	R:R:H174	R:R:Y268	37.0807	8.71	Yes	Yes	0	4	6
60	R:R:W265	R:R:Y268	31.9394	7.72	Yes	Yes	3	8	6
61	R:R:M117	R:R:W265	20.393	6.98	No	Yes	3	7	8
62	R:R:W265	R:R:Y200	12.7638	6.75	Yes	Yes	3	8	5
63	R:R:I269	R:R:Y268	12.8962	3.63	No	Yes	3	7	6
64	R:R:I269	R:R:Y200	13.2006	6.04	No	Yes	3	7	5
65	R:R:K133	R:R:T132	20.36	3	Yes	No	0	5	6
66	R:R:T132	R:R:Y128	22.5567	16.23	No	Yes	0	6	8
67	R:R:T210	R:R:Y128	33.3422	7.49	No	Yes	0	6	8
68	R:R:S124	R:R:T210	35.4595	4.8	No	No	0	8	6
69	R:R:S124	R:R:Y211	43.7967	3.82	No	Yes	0	8	9
70	R:R:I195	R:R:Y200	33.8847	8.46	No	Yes	0	6	5
71	R:R:F191	R:R:I195	28.7236	3.77	No	No	0	5	6
72	R:R:F191	R:R:P163	20.1217	7.22	No	No	0	5	5
73	R:R:L162	R:R:P163	13.5314	1.64	No	No	0	4	5
74	R:R:L159	R:R:L162	11.3081	1.38	No	No	0	3	4
75	R:R:F272	R:R:Y268	33.7524	9.28	Yes	Yes	0	5	6
76	R:R:F272	R:R:Y173	16.6413	6.19	Yes	Yes	0	5	1
77	R:R:F272	R:R:T192	13.9284	10.38	Yes	No	0	5	4
78	R:R:F255	R:R:Y211	18.1499	7.22	No	Yes	0	5	9
79	R:R:F255	R:R:M252	13.6505	17.42	No	No	10	5	7
80	R:R:M252	R:R:R256	11.4405	3.72	No	No	0	7	6
81	R:R:D308	R:R:F311	13.5645	3.58	Yes	Yes	1	8	9
82	R:R:C299	R:R:F298	39.4759	4.19	No	No	0	5	6
83	R:R:C299	R:R:L264	36.5182	1.59	No	No	0	5	8
84	R:R:L264	R:R:S295	30.5631	3	No	No	0	8	6
85	R:R:L292	R:R:S295	27.5657	4.5	No	No	0	6	6
86	R:R:L292	R:R:P267	24.555	3.28	No	No	0	6	9
87	R:R:P267	R:R:T289	18.494	1.75	No	No	0	9	5
88	R:R:T289	R:R:Y271	12.3801	6.24	No	No	0	5	5
89	R:R:A305	R:R:F311	11.7846	2.77	No	Yes	0	7	9
90	R:R:F67	R:R:I123	41.7058	5.02	Yes	No	0	8	9
91	R:R:L199	R:R:Y200	33.1701	4.69	Yes	Yes	0	7	5
92	R:R:M117	R:R:Y200	29.4515	4.79	No	Yes	3	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HIX_nogp

PDB Summary
PDB	8HIX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	266
Number of Links	289
Number of Hubs	32
Number of Links mediated by Hubs	123
Number of Communities	10
Number of Nodes involved in Communities	42
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	45041
Length Of Smallest Path	3
Average Path Length	12.8141
Length of Longest Path	28
Minimum Path Strength	1.175
Average Path Strength	5.92787
Maximum Path Strength	16.18
Minimum Path Correlation	0.7
Average Path Correlation	0.952194
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	66.029
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.3867
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cellular response to nitrogen compound • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cellular response to endogenous stimulus • response to hormone • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to insulin • cellular response to insulin stimulus • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • developmental process • regulation of multicellular organism growth • multicellular organismal process • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of biological process • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of developmental growth • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • regulation of cellular response to insulin stimulus • negative regulation of cell communication • negative regulation of cellular process • regulation of signaling • negative regulation of response to stimulus • regulation of insulin receptor signaling pathway • negative regulation of signal transduction • negative regulation of cellular response to insulin stimulus • regulation of response to stimulus • negative regulation of insulin receptor signaling pathway • regulation of cell communication • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of smell • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99679
Sequence	>8HIX_nogp_Chain_R V N F C L L E V L I I V F L T V L I I S G N I I V I F V F H C A P L L N H H T T S Y F I Q T M A Y A D L F V G V S C V V P S L S L L H H P L P V E E S L T C Q I F G F V V S V L K S V S M W S L A C I S I D R Y I A I T K P L T Y N T L V T P W R L R L C I F L I W L Y S T L V F L P S F F H W G K P G Y H G D V F Q W C A E S W H T D S Y F T L F I V M M L Y A P A A L I V C F T Y F N I F R I C Q Q H T K D I S E R Q A R F S S M V L F R I T S V F Y I L W L P Y I I Y F L L E S S T G H S N R F A S F L T T W L A I S N S F C N P V I Y A L S D S T F Q R G L K R L S G A M C T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HMV	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	2.91	2023-03-01	doi.org/10.1002/mco2.205
	8HMV (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		2.91	2023-03-01	doi.org/10.1002/mco2.205
	8HIX	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HIX (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ0	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ0 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ2	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.8	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ2 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.8	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ1	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.27	2023-12-27	doi.org/10.1038/s41467-023-35882-w
	8HJ1 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.27	2023-12-27	doi.org/10.1038/s41467-023-35882-w

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