Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 4.675135
2A:A:L37 6.215419
3A:A:K46 7.5075409
4A:A:H188 7.8475413
5A:A:F191 8.14135
6A:A:F196 7.866137
7A:A:K197 7.9275416
8A:A:F199 7.528515
9A:A:V201 4.99419
10A:A:Q204 4.906519
11A:A:K210 5.8819
12A:A:W211 4.97714719
13A:A:H213 5.698518
14A:A:F215 7.254519
15A:A:I222 3.9565107
16A:A:F223 5.888509
17A:A:V225 3.684507
18A:A:Y230 5.382548
19A:A:D231 3.7225449
20A:A:M243 5.24448
21A:A:F250 6.958336189
22A:A:C254 4.16754185
23A:A:W258 7.662505
24A:A:I265 3.1445108
25A:A:L266 5.375449
26A:A:F267 4.921437109
27A:A:L268 5.416548
28A:A:N269 3.415409
29A:A:F274 4.88833649
30A:A:K277 5.255449
31A:A:C286 5.632546
32A:A:Y287 6.07143747
33A:A:Y290 7.8185177
34A:A:Y296 8.96404
35A:A:E298 6.85254174
36A:A:Y302 8.0975406
37A:A:I303 4.0825447
38A:A:F307 5.356508
39A:A:Y320 7.3285217
40A:A:T321 8.23445
41A:A:H322 6.6365109
42A:A:T324 6.086109
43A:A:N331 8.6385108
44A:A:F336 5.778336138
45A:A:I343 5.14157
46A:A:N347 5.6365158
47A:A:L353 3.748507
48B:B:L7 2.805408
49B:B:I18 3.6875407
50B:B:D27 8.24254248
51B:B:L30 5.2675405
52B:B:I37 3.6425142
53B:B:V40 3.535143
54B:B:R48 5.775477
55B:B:R49 5.1125477
56B:B:H54 6.978129
57B:B:K57 8.2275419
58B:B:Y59 10.584518
59B:B:M61 4.2075406
60B:B:W63 9.0475477
61B:B:S72 6.384129
62B:B:Q75 7.0025419
63B:B:D76 5.895129
64B:B:I80 9.44754128
65B:B:I81 4.64557
66B:B:W82 10.52836129
67B:B:S84 4.0375475
68B:B:K89 6.663336129
69B:B:V90 4.3575455
70B:B:H91 4.456555
71B:B:I93 4.7175457
72B:B:W99 7.78619
73B:B:Y105 4.945856
74B:B:C114 3.28167658
75B:B:C121 4.1354118
76B:B:I123 3.1625196
77B:B:Y124 4.955656
78B:B:L126 3.874555
79B:B:E130 2.415403
80B:B:V133 4.2925454
81B:B:V135 4.12454
82B:B:L139 6.852509
83B:B:H142 7.02758119
84B:B:Y145 4.92875818
85B:B:L146 3.71754117
86B:B:F151 4.005609
87B:B:L152 4.502503
88B:B:T159 4.556119
89B:B:D163 9.3354119
90B:B:C166 3.885438
91B:B:L168 4.8425436
92B:B:W169 11.3465118
93B:B:D170 8.164269
94B:B:Q176 6.68754114
95B:B:T178 4.835434
96B:B:F180 7.59833637
97B:B:H183 9.654539
98B:B:L190 3.90167635
99B:B:F199 7.142539
100B:B:S201 5.2625439
101B:B:D205 6.87539
102B:B:K209 11.4475436
103B:B:W211 9.854538
104B:B:Q220 9.035467
105B:B:F222 8.324568
106B:B:H225 7.46143769
107B:B:D228 7.765419
108B:B:I232 5.845468
109B:B:F234 6.4505
110B:B:F235 7.964586
111B:B:P236 6.7525487
112B:B:N237 7.09754205
113B:B:F241 8.20167666
114B:B:T243 5.952568
115B:B:D246 6.1425419
116B:B:T249 5.356566
117B:B:R251 10.534568
118B:B:F253 6.705666
119B:B:D258 9.905467
120B:B:Y264 5.84685
121B:B:F278 6.11571787
122B:B:R283 6.5656149
123B:B:L284 4.288505
124B:B:Y289 5.88572787
125B:B:C294 3.8975495
126B:B:W297 6.4975488
127B:B:L300 3.918336146
128B:B:R304 7.11405
129B:B:H311 8.324599
130B:B:V315 4.6625497
131B:B:L318 4.764596
132B:B:M325 6.3375405
133B:B:T329 6.17598
134B:B:W332 11.47619
135B:B:D333 6.33599
136B:B:L336 4.595717127
137B:B:K337 8.79496
138B:B:W339 7.728599
139B:B:N340 6.915479
140G:G:L19 2.794509
141G:G:E22 5.055409
142G:G:R27 3.356508
143G:G:H44 9.04406
144G:G:D48 5.764509
145G:G:L50 3.88409
146G:G:L51 5.3265146
147G:G:P60 7.185479
148G:G:F61 5.65878
149R:R:K6 4.10754165
150R:R:I17 4.095407
151R:R:L22 3.745406
152R:R:N25 5.48409
153R:R:F32 5.34407
154R:R:V33 1.86404
155R:R:L48 6.6875408
156R:R:L51 3.7125429
157R:R:D55 4.774529
158R:R:L58 6.092527
159R:R:L62 2.7275428
160R:R:W75 8.32409
161R:R:F87 5.57406
162R:R:F89 6.00167627
163R:R:I93 4.0975428
164R:R:Y94 7.41667628
165R:R:C95 5.92254287
166R:R:T97 5.09428
167R:R:L99 3.574508
168R:R:R107 5.466239
169R:R:Y108 8.4954298
170R:R:Y117 7.34155
171R:R:V147 1.585404
172R:R:V176 3.0475404
173R:R:L177 3.005402
174R:R:L183 5.41425
175R:R:L187 7.0425426
176R:R:F188 6.604528
177R:R:F189 4.7775424
178R:R:P191 5.905409
179R:R:Y199 8.1245238
180R:R:F202 3.5375408
181R:R:H211 7.714213
182R:R:R216 6.382505
183R:R:F231 5.4775429
184R:R:F235 6.06629
185R:R:Y238 7.084527
186R:R:N239 8.0725428
187R:R:H242 5.448526
188R:R:P252 5.51421
189R:R:W254 4.468524
190R:R:R255 5.196525
191R:R:N265 8.046529
192R:R:F273 5.0275409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:M61 11.8894.86NoYes076
2B:B:C317 B:B:S316 12.02813.44NoNo079
3B:B:S316 B:B:W332 12.19476.18NoYes099
4B:B:K57 B:B:W332 17.996715.08YesYes199
5B:B:K57 B:B:Q75 18.09594.07YesYes199
6B:B:Q75 B:B:W99 36.49956.57YesYes199
7B:B:W332 B:B:Y59 17.996615.43YesYes198
8B:B:Q75 B:B:Y59 18.155811.27YesYes198
9A:A:F215 B:B:W99 37.80879.02YesYes199
10A:A:F215 A:A:L37 37.360213.4YesYes199
11A:A:L37 A:A:L39 37.6252.77YesNo099
12A:A:I253 A:A:L39 37.54987.14NoNo089
13A:A:F223 A:A:I253 1002.51YesNo098
14A:A:F223 A:A:F250 93.009918.22YesYes099
15A:A:C254 A:A:F250 49.32636.98YesYes1859
16A:A:C254 A:A:K317 49.10834.85YesNo1857
17A:A:K317 A:A:R313 98.0052.48NoNo074
18A:A:R313 A:A:T316 97.62.59NoNo043
19A:A:T316 R:R:R216 97.32962.59NoYes035
20R:R:R216 R:R:V212 17.05382.62YesNo053
21R:R:Q209 R:R:V212 15.99162.87NoNo053
22R:R:P210 R:R:Q209 15.81587.9NoNo035
23R:R:H211 R:R:P210 15.64044.58YesNo033
24B:B:L190 B:B:S160 17.17733YesNo056
25B:B:S147 B:B:S160 32.29113.26NoNo096
26B:B:S147 B:B:Y145 32.34362.54NoYes098
27A:A:W211 B:B:Y145 64.2173.86YesYes198
28A:A:R208 A:A:W211 62.55296NoYes099
29A:A:R208 A:A:S252 62.50975.27NoNo097
30A:A:I253 A:A:S252 62.46733.1NoNo087
31A:A:F250 A:A:I264 49.08613.77YesNo1896
32A:A:I264 A:A:K317 49.03162.91NoNo1867
33A:A:Y320 R:R:H211 11.691416.33YesYes2173
34A:A:K210 B:B:Y145 32.35394.78YesYes198
35A:A:K210 B:B:D228 16.00398.3YesYes199
36A:A:K210 B:B:D246 16.00412.77YesYes199
37A:A:F354 R:R:R216 81.186611.76NoYes055
38A:A:F354 A:A:L348 80.898610.96NoNo059
39A:A:L348 A:A:L353 80.75474.15NoYes097
40A:A:L353 R:R:R107 78.64693.64YesYes079
41B:B:F199 B:B:L190 12.18774.87YesYes395
42B:B:F199 B:B:W211 11.325511.02YesYes398
43B:B:K209 B:B:W211 10.47029.28YesYes368
44B:B:K209 B:B:T221 14.920312.01YesNo067
45B:B:T221 G:G:E22 14.73798.47NoYes079
46B:B:C218 B:B:W211 10.34876.53NoYes358
47B:B:C218 G:G:Q18 10.22456.1NoNo059
48G:G:E22 G:G:Q18 10.10396.37YesNo099
49B:B:I18 G:G:E22 16.68222.73YesYes079
50B:B:I18 B:B:R22 13.99285.01YesNo076
51B:B:D258 B:B:R22 10.866311.91YesNo076
52B:B:R283 G:G:L51 10.97318.5YesYes1496
53B:B:L261 B:B:L30 15.815211.07NoYes055
54B:B:L261 G:G:V30 17.37552.98NoNo058
55B:B:Q259 G:G:V30 22.12685.73NoNo068
56B:B:L30 B:B:M262 14.1035.65YesNo054
57B:B:M45 G:G:L50 16.74872.83NoYes049
58B:B:H311 B:B:T329 13.88316.85YesYes998
59B:B:N313 B:B:W332 24.93317.91NoYes079
60B:B:D333 B:B:N313 24.76622.69YesNo097
61B:B:S160 B:B:V187 15.36938.08NoNo069
62B:B:S201 B:B:V187 14.66813.23YesNo399
63B:B:G238 B:B:N237 10.69413.39NoYes075
64B:B:F234 B:B:G238 11.70313.01YesNo057
65B:B:F234 B:B:V200 14.73697.87YesNo056
66B:B:F241 B:B:V200 11.48613.11YesNo666
67B:B:D228 B:B:S227 15.96565.89YesNo196
68B:B:D247 B:B:S227 31.78832.94NoNo096
69B:B:D247 B:B:T249 31.51685.78NoYes096
70B:B:H225 B:B:T249 19.70892.74YesYes696
71B:B:D246 B:B:S227 15.96564.42YesNo196
72B:B:D258 B:B:F222 11.8057.17YesYes678
73B:B:R251 B:B:T249 11.263510.35YesYes686
74B:B:M262 B:B:Y264 12.98157.18NoYes845
75B:B:W297 B:B:Y264 10.154510.61YesYes885
76R:R:R107 R:R:Y199 31.01629.26YesYes2398
77R:R:L228 R:R:Y199 26.27224.69NoYes088
78R:R:I196 R:R:L228 13.05962.85NoNo048
79R:R:I196 R:R:M192 12.89972.92NoNo046
80R:R:F188 R:R:M192 25.47423.73YesNo086
81R:R:F188 R:R:N239 34.838518.12YesYes288
82R:R:N239 R:R:Y238 18.9145.81YesYes287
83R:R:R255 R:R:Y238 17.04354.12YesYes257
84R:R:W253 R:R:W254 11.04618.43NoYes014
85R:R:K6 R:R:W253 10.04233.48YesNo051
86R:R:L228 R:R:L232 13.05962.77NoNo085
87R:R:L232 R:R:M192 12.89974.24NoNo056
88R:R:F273 R:R:R107 40.05674.28YesYes099
89R:R:F273 R:R:L51 36.68073.65YesYes099
90R:R:L51 R:R:S96 30.47233YesNo299
91R:R:F235 R:R:S96 30.50985.28YesNo299
92R:R:F188 R:R:F235 13.32453.22YesYes289
93R:R:F235 R:R:S262 13.17642.64YesNo098
94R:R:I93 R:R:S262 10.09996.19YesNo088
95B:B:Q259 B:B:R22 23.19813.5NoNo066
96B:B:M45 B:B:W339 16.94623.49NoYes949
97B:B:F253 B:B:H225 11.03094.53YesYes669
98B:B:F253 B:B:R251 10.99775.34YesYes668
99B:B:F222 B:B:F253 13.96489.65YesYes686
100B:B:D333 B:B:H311 23.46228.82YesYes999
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8J23
Class A
SubFamily Lipid
Type Free Fatty Acid
SubType FFA2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.2
Date 2024-04-17
D.O.I. To be published
Net Summary
Imin 2.51
Number of Linked Nodes 821
Number of Links 1067
Number of Hubs 192
Number of Links mediated by Hubs 702
Number of Communities 29
Number of Nodes involved in Communities 283
Number of Links involved in Communities 429
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 3015541
Length Of Smallest Path 3
Average Path Length 31.5867
Length of Longest Path 55
Minimum Path Strength 1.37
Average Path Strength 5.86579
Maximum Path Strength 21.31
Minimum Path Correlation 0.7
Average Path Correlation 0.990043
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 39.701
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.2238
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • positive regulation of response to biotic stimulus   • immune response-regulating cell surface receptor signaling pathway   • regulation of cellular process   • response to stimulus   • pattern recognition receptor signaling pathway   • response to biotic stimulus   • cell communication   • immune response-activating signaling pathway   • positive regulation of immune response   • regulation of immune system process   • signal transduction   • positive regulation of immune system process   • innate immune response-activating signaling pathway   • regulation of biological process   • immune response   • response to other organism   • immune response-activating cell surface receptor signaling pathway   • regulation of innate immune response   • response to external stimulus   • regulation of response to stimulus   • defense response to other organism   • positive regulation of defense response   • activation of innate immune response   • regulation of immune response   • activation of immune response   • regulation of defense response   • regulation of response to biotic stimulus   • biological process involved in interspecies interaction between organisms   • regulation of response to external stimulus   • signaling   • positive regulation of biological process   • innate immune response activating cell surface receptor signaling pathway   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • immune response-regulating signaling pathway   • regulation of response to stress   • response to stress   • innate immune response   • response to external biotic stimulus   • cell surface pattern recognition receptor signaling pathway   • positive regulation of innate immune response   • cell surface receptor signaling pathway   • defense response   • biological regulation   • defense response to symbiont   • immune system process   • cellular process   • regulation of localization   • regulation of hormone secretion   • nitrogen compound transport   • regulation of peptide secretion   • transport   • hormone secretion   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of biological quality   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • export from cell   • cell-cell signaling   • establishment of localization   • regulation of secretion   • peptide transport   • peptide hormone secretion   • regulation of cell communication   • hormone transport   • protein localization   • negative regulation of protein transport   • establishment of protein localization   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • cellular macromolecule localization   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • negative regulation of protein secretion   • cellular localization   • regulation of protein localization   • negative regulation of signaling   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of establishment of protein localization   • regulation of protein transport   • negative regulation of insulin secretion   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • macromolecule localization   • insulin secretion   • multicellular organismal process   • positive regulation of interleukin-8 production   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • cytokine production   • regulation of cytokine production   • positive regulation of macromolecule metabolic process   • regulation of multicellular organismal process   • positive regulation of cellular process   • regulation of biosynthetic process   • interleukin-8 production   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • positive regulation of gene expression   • positive regulation of multicellular organismal process   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • positive regulation of cytokine production   • regulation of metabolic process   • regulation of interleukin-8 production   • regulation of chemokine production   • chemokine production   • positive regulation of chemokine production   • cell chemotaxis   • leukocyte chemotaxis involved in inflammatory response   • chemotaxis   • leukocyte migration involved in inflammatory response   • leukocyte migration   • cellular response to chemical stimulus   • taxis   • response to chemical   • cell migration   • inflammatory response   • cell motility   • leukocyte chemotaxis   • locomotion   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • developmental process   • fat cell differentiation   • cellular developmental process   • cell differentiation   • mucosal immune response   • organ or tissue specific immune response   • lipid storage   • nutrient storage   • positive regulation of acute inflammatory response   • positive regulation of inflammatory response   • regulation of acute inflammatory response to non-antigenic stimulus   • acute inflammatory response   • acute inflammatory response to non-antigenic stimulus   • regulation of inflammatory response   • positive regulation of acute inflammatory response to non-antigenic stimulus   • regulation of acute inflammatory response   • response to lipid   • response to fatty acid   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to fatty acid   • cellular response to lipid   • positive regulation of cell communication   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • positive regulation of peptide hormone secretion   • positive regulation of protein localization   • positive regulation of secretion by cell   • positive regulation of protein transport   • positive regulation of hormone secretion   • positive regulation of secretion   • positive regulation of peptide secretion   • positive regulation of protein secretion   • positive regulation of transport   • positive regulation of signaling   • regulation of immune effector process   • positive regulation of immune effector process   • cytokine production involved in immune response   • production of molecular mediator of immune response   • regulation of cytokine production involved in immune response   • immune effector process   • positive regulation of cytokine production involved in immune response   • positive regulation of production of molecular mediator of immune response   • regulation of production of molecular mediator of immune response   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • ligand-gated ion channel signaling pathway   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • cell projection   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to endogenous stimulus   • response to peptide hormone   • response to nitrogen compound   • cell division   • mononuclear cell migration   • lymphocyte migration   • T cell migration   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to alcohol   • response to forskolin   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8J23_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKTGIV ETHFTFKDL HFKMFDVGG QRSERKKWI HCFEGVTAI 
IFCVALSDY DLMNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCAT DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8J23_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8J23_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtO15552
Sequence
>8J23_Chain_R
DWKSSLILM AYIIIFLTG LPANLLALR AFVGRVRQP QPAPVHILL 
LSLTLADLL LLLLLPFKI IEAASNFRW YLPKIVCAL TGFGFYSSI 
YCSTWLLAG ISIERYLGV AFPVQYKLS RRPLYGVIA ALVAWVMSF 
GHCTIVIIV QTCYENFTD EQLDVVLPV RLELCLVLF FIPMAVTIF 
CYWRFVWIM LTQPHVGAQ RRRRAVGLA VVTLLNFLV CFGPYNVSH 
LVGFYQRKS PWWRSIAVV FSSLNASLD PLLFYF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9K1DALipidFree Fatty AcidFFA2Homo sapiensButanoic acidCholesterolGi1/β1/γ23.342024-12-1110.1016/j.celrep.2024.115024
9K1D (No Gprot) ALipidFree Fatty AcidFFA2Homo sapiensButanoic acidCholesterol3.342024-12-1110.1016/j.celrep.2024.115024
8J23ALipidFree Fatty AcidFFA2Homo sapiens--Gi1/β1/γ23.22024-04-17To be published
8J23 (No Gprot) ALipidFree Fatty AcidFFA2Homo sapiens--3.22024-04-17To be published
8T3SALipidFree Fatty AcidFFA2Homo sapiensButyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ23.072024-01-2410.1126/sciadv.adj2384
8T3S (No Gprot) ALipidFree Fatty AcidFFA2Homo sapiensButyric acid-3.072024-01-2410.1126/sciadv.adj2384
8J24ALipidFree Fatty AcidFFA2Homo sapiensAcetic acid-Gi1/β1/γ22.62024-01-2410.1038/s41422-023-00914-z
8J24 (No Gprot) ALipidFree Fatty AcidFFA2Homo sapiensAcetic acid-2.62024-01-2410.1038/s41422-023-00914-z
8J22ALipidFree Fatty AcidFFA2Homo sapiensTUG-1375-Gi1/β1/γ23.22024-01-2410.1038/s41422-023-00914-z
8J22 (No Gprot) ALipidFree Fatty AcidFFA2Homo sapiensTUG-1375-3.22024-01-2410.1038/s41422-023-00914-z




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8J23.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.