Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:K6 4.10754205
2R:R:I17 4.095407
3R:R:L22 3.745406
4R:R:N25 5.48409
5R:R:F32 5.34407
6R:R:V33 1.86403
7R:R:L48 6.6875408
8R:R:L51 3.71254139
9R:R:D55 5.30254139
10R:R:L58 6.92254226
11R:R:W75 8.32408
12R:R:F87 5.57404
13R:R:F89 7.724226
14R:R:Y94 7.41667687
15R:R:C95 5.9225406
16R:R:L99 3.574508
17R:R:R107 5.466239
18R:R:Y108 8.4954248
19R:R:Y117 7.34176
20R:R:V147 1.585404
21R:R:V176 3.0475404
22R:R:L177 3.005403
23R:R:L187 7.0425485
24R:R:F188 7.6075408
25R:R:P191 5.905409
26R:R:Y199 9.48754239
27R:R:F202 3.5375408
28R:R:H211 7.714254
29R:R:R216 7.3225405
30R:R:F231 5.47754139
31R:R:F235 6.7445138
32R:R:Y238 7.084587
33R:R:H242 6.1725486
34R:R:W254 4.91403
35R:R:R255 5.196584
36R:R:F273 5.0275409
37A:A:V34 4.675115
38A:A:K46 7.5075409
39A:A:F191 8.14115
40A:A:F196 7.866117
41A:A:K197 7.9275416
42A:A:F199 7.528515
43A:A:V201 4.99419
44A:A:Q204 4.906519
45A:A:K210 6.42571719
46A:A:W211 4.97714719
47A:A:H213 5.698518
48A:A:F215 7.254519
49A:A:I222 4.3175407
50A:A:F223 6.705409
51A:A:V225 3.95407
52A:A:Y230 5.382548
53A:A:D231 3.7225449
54A:A:M243 5.24448
55A:A:F250 6.958336189
56A:A:C254 4.16754185
57A:A:W258 7.662505
58A:A:I265 3.3025408
59A:A:L266 5.3754169
60A:A:F267 5.8645149
61A:A:L268 5.4165168
62A:A:N269 3.415409
63A:A:F274 5.364509
64A:A:K277 5.255449
65A:A:C286 5.632546
66A:A:Y287 6.67429747
67A:A:Y290 7.818547
68A:A:Y296 10.3625404
69A:A:E298 7.205444
70A:A:Y302 9.7825446
71A:A:F307 6.0675408
72A:A:Y320 7.3285257
73A:A:T321 8.234165
74A:A:T324 6.086149
75A:A:C325 2.0725407
76A:A:N331 10.164148
77A:A:F336 5.778336118
78A:A:N347 5.6365178
79A:A:L353 3.748507
80B:B:L7 2.805408
81B:B:D27 8.24254278
82B:B:I37 3.6425122
83B:B:V40 3.535123
84B:B:R48 5.775467
85B:B:R49 5.1125467
86B:B:H54 7.59857799
87B:B:K57 8.2275419
88B:B:Y59 10.584518
89B:B:W63 9.0475467
90B:B:S72 6.38499
91B:B:Q75 7.0025419
92B:B:D76 5.89599
93B:B:I80 9.4475498
94B:B:I81 4.64537
95B:B:W82 10.5283699
96B:B:K89 6.66333699
97B:B:V90 4.3575435
98B:B:I93 4.7175437
99B:B:W99 7.78619
100B:B:Y105 4.945836
101B:B:C114 3.4538
102B:B:C121 4.1354108
103B:B:Y124 5.408536
104B:B:L126 4.2435
105B:B:E130 2.415403
106B:B:V135 4.12434
107B:B:L139 6.852509
108B:B:H142 7.647109
109B:B:Y145 5.27718
110B:B:L146 3.71754107
111B:B:F151 4.304509
112B:B:L152 4.502503
113B:B:T159 4.556109
114B:B:D163 9.3354109
115B:B:L168 4.8425426
116B:B:W169 11.3465108
117B:B:D170 8.164309
118B:B:Q176 6.68754104
119B:B:T178 4.835424
120B:B:F180 7.59833627
121B:B:H183 11.37429
122B:B:L190 4.128525
123B:B:F199 8.23429
124B:B:S201 5.2625429
125B:B:D205 6.87529
126B:B:K209 11.4475426
127B:B:W211 9.854528
128B:B:Q220 9.035457
129B:B:F222 8.324558
130B:B:H225 8.24833659
131B:B:D228 7.765419
132B:B:I232 5.845458
133B:B:F234 6.4505
134B:B:F235 7.9645156
135B:B:P236 6.75254157
136B:B:N237 7.09754195
137B:B:F241 9.324556
138B:B:T243 6.7925458
139B:B:T249 6.01456
140B:B:R251 10.534558
141B:B:F253 6.705656
142B:B:D258 9.905457
143B:B:Y264 6.474505
144B:B:F278 6.115717157
145B:B:R283 7.325129
146B:B:L284 4.288505
147B:B:Y289 5.885727327
148B:B:C294 3.8975475
149B:B:H311 8.324579
150B:B:V315 4.6625477
151B:B:L318 5.2625476
152B:B:M325 6.3375405
153B:B:T329 6.17578
154B:B:W332 11.47619
155B:B:D333 7.24479
156B:B:L336 5.354597
157B:B:K337 8.79476
158B:B:W339 7.728579
159B:B:N340 6.915469
160G:G:L19 2.794509
161G:G:R27 3.5675408
162G:G:D48 5.764509
163G:G:L51 5.3265126
164G:G:P60 7.185469
165G:G:F61 6.08768
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:N239 R:R:Y238 10.11495.81NoYes887
2R:R:F188 R:R:N239 26.870418.12YesNo088
3R:R:F188 R:R:F235 28.72773.22YesYes088
4R:R:F235 R:R:S96 36.42535.28YesNo1389
5R:R:L51 R:R:S96 36.38433YesNo1399
6R:R:F273 R:R:L51 41.91033.65YesYes099
7R:R:F273 R:R:L48 42.37068.53YesYes098
8R:R:L48 R:R:V44 49.48162.98YesNo087
9R:R:E106 R:R:V44 61.70542.85NoNo087
10R:R:E106 R:R:Y117 61.94345.61NoYes086
11A:A:N347 R:R:Y117 62.011711.63YesYes1786
12A:A:I343 A:A:N347 65.02594.25NoYes078
13A:A:I343 R:R:K118 65.733911.63NoNo075
14A:A:V34 R:R:K118 65.96963.04YesNo055
15A:A:F196 A:A:V34 66.22427.87YesYes1175
16A:A:F189 A:A:F196 81.436215NoYes097
17A:A:F189 A:A:K54 81.88364.96NoNo097
18A:A:K54 A:A:T190 82.10714.5NoNo073
19A:A:H195 A:A:T190 82.33049.58NoNo043
20A:A:E33 A:A:H195 41.27683.69NoNo164
21A:A:E33 A:A:K197 41.37665.4NoYes166
22A:A:F199 A:A:K197 82.78293.72YesYes156
23A:A:F199 B:B:W99 69.238914.03YesYes159
24B:B:Q75 B:B:W99 1006.57YesYes199
25B:B:K57 B:B:Q75 49.77794.07YesYes199
26B:B:K57 B:B:W332 49.536915.08YesYes199
27B:B:S316 B:B:W332 99.00196.18NoYes099
28B:B:C317 B:B:S316 98.91393.44NoNo079
29B:B:C317 B:B:M61 98.82574.86NoNo076
30B:B:L70 B:B:M61 87.61425.65NoNo056
31B:B:L70 B:B:S84 85.98663NoNo655
32B:B:I338 B:B:S84 85.97833.1NoNo655
33B:B:I338 G:G:F61 85.32246.28NoYes658
34B:B:Y85 G:G:F61 84.48357.22NoYes648
35B:B:R68 B:B:Y85 86.92515.14NoNo054
36B:B:D83 B:B:R68 86.821516.68NoNo085
37B:B:D83 B:B:T86 11.002313.01NoNo086
38B:B:N88 B:B:T86 10.825810.24NoNo076
39A:A:H188 A:A:H195 41.276811.94NoNo134
40A:A:H188 A:A:K197 41.376611.79NoYes136
41B:B:Q75 B:B:Y59 49.846111.27YesYes198
42B:B:W332 B:B:Y59 49.537115.43YesYes198
43A:A:C351 R:R:R107 11.7564.18NoYes049
44B:B:D83 B:B:V90 76.51252.92NoYes085
45A:A:F199 A:A:F215 13.8194.29YesYes159
46A:A:I253 A:A:S252 21.83553.1NoNo087
47A:A:R208 A:A:S252 21.98595.27NoNo097
48A:A:R208 A:A:W211 22.13686NoYes099
49A:A:F215 A:A:W211 42.80243.01YesYes199
50A:A:F223 A:A:L266 13.05623.65YesYes099
51A:A:F223 A:A:I253 21.5332.51YesNo098
52A:A:W211 B:B:Y145 22.54863.86YesYes198
53B:B:G115 B:B:L146 23.69653.42NoYes097
54B:B:C114 B:B:G115 24.8723.92YesNo089
55B:B:L126 B:B:V133 21.14054.47YesNo354
56B:B:I81 B:B:L126 21.26752.85YesYes375
57B:B:I81 B:B:V90 51.57014.61YesYes375
58B:B:V133 B:B:Y124 14.15363.79NoYes346
59A:A:K210 B:B:Y145 21.03164.78YesYes198
60A:A:K210 B:B:D228 20.10368.3YesYes199
61G:G:E22 G:G:L19 15.26452.65NoYes099
62B:B:K209 B:B:W211 11.26639.28YesYes268
63B:B:F199 B:B:W211 23.027811.02YesYes298
64B:B:F199 B:B:L190 26.34824.87YesYes295
65B:B:L190 B:B:R150 41.87073.64YesNo056
66B:B:H62 B:B:R150 46.318720.31NoNo066
67B:B:H62 B:B:Y105 46.60674.36NoYes066
68B:B:L69 B:B:Y105 23.99447.03NoYes056
69B:B:L69 B:B:V90 24.26012.98NoYes055
70B:B:I81 B:B:Y105 24.73426.04YesYes376
71B:B:F253 B:B:R251 17.14415.34YesYes568
72B:B:R251 B:B:T249 18.745310.35YesYes586
73B:B:D247 B:B:T249 19.37515.78NoYes096
74B:B:D247 B:B:S227 19.6812.94NoNo096
75B:B:D228 B:B:S227 19.80815.89YesNo196
76B:B:G319 B:B:S277 13.28243.71NoNo055
77B:B:G319 B:B:M61 13.45773.49NoNo056
78B:B:I123 B:B:L139 10.05052.85NoYes069
79B:B:C121 B:B:L139 12.76846.35YesYes089
80R:R:N239 R:R:Y94 16.49655.81NoYes887
81A:A:C351 R:R:V44 11.98946.83NoNo047
82A:A:F215 B:B:W99 29.96889.02YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8J23
Class A
SubFamily Lipid
Type Free fatty acid
SubType FFA2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.2
Date 2024-04-17
D.O.I. To be published
Net Summary
Imin 2.85
Number of Linked Nodes 821
Number of Links 1009
Number of Hubs 165
Number of Links mediated by Hubs 609
Number of Communities 32
Number of Nodes involved in Communities 246
Number of Links involved in Communities 351
Path Summary
Number Of Nodes in MetaPath 83
Number Of Links MetaPath 82
Number of Shortest Paths 1887770
Length Of Smallest Path 3
Average Path Length 37.2742
Length of Longest Path 70
Minimum Path Strength 1.35
Average Path Strength 6.48232
Maximum Path Strength 21.31
Minimum Path Correlation 0.7
Average Path Correlation 0.9838
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 39.1054
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.3068
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtO15552
Sequence
>8J23_Chain_R
DWKSSLILM AYIIIFLTG LPANLLALR AFVGRVRQP QPAPVHILL 
LSLTLADLL LLLLLPFKI IEAASNFRW YLPKIVCAL TGFGFYSSI 
YCSTWLLAG ISIERYLGV AFPVQYKLS RRPLYGVIA ALVAWVMSF 
GHCTIVIIV QTCYENFTD EQLDVVLPV RLELCLVLF FIPMAVTIF 
CYWRFVWIM LTQPHVGAQ RRRRAVGLA VVTLLNFLV CFGPYNVSH 
LVGFYQRKS PWWRSIAVV FSSLNASLD PLLFYF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8J23_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKTGIV ETHFTFKDL HFKMFDVGG QRSERKKWI HCFEGVTAI 
IFCVALSDY DLMNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCAT DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8J23_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8J23_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8J22ALipidFree fatty acidFFA2Homo sapiensTUG-1375-Gi1/&β;1/&γ;23.22024-01-2410.1038/s41422-023-00914-z
8J23ALipidFree fatty acidFFA2Homo sapiens--Gi1/&β;1/&γ;23.22024-04-17To be published
8J24ALipidFree fatty acidFFA2Homo sapiensAcetic acid-Gi1/&β;1/&γ;22.62024-01-2410.1038/s41422-023-00914-z
8T3SALipidFree fatty acidFFA2Homo sapiensButyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;23.072024-01-2410.1126/sciadv.adj2384




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8J23.zip



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