psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y90	15.33	Yes	Yes	1	0	5
2	L:L:?1	R:R:Y165	13.8	Yes	Yes	1	0	4
3	L:L:?1	R:R:R180	7.94	Yes	Yes	1	0	5
4	L:L:?1	R:R:L183	7.24	Yes	No	0	0	5
5	L:L:?1	R:R:Y238	7.66	Yes	Yes	1	0	7
6	L:L:?1	R:R:H242	3.36	Yes	Yes	1	0	6
7	L:L:?1	R:R:R255	4.77	Yes	Yes	1	0	5
8	R:R:D4	R:R:K6	5.53	No	No	0	4	5
9	R:R:D4	R:R:S7	4.42	No	No	0	4	3
10	R:R:L9	R:R:W5	4.56	No	No	0	6	7
11	R:R:N72	R:R:S7	2.98	No	No	0	3	3
12	R:R:F73	R:R:S7	3.96	Yes	No	0	1	3
13	R:R:F73	R:R:I10	5.02	Yes	Yes	2	1	5
14	R:R:I10	R:R:S256	3.1	Yes	No	2	5	4
15	R:R:A69	R:R:L11	4.73	No	No	0	5	5
16	R:R:L62	R:R:Y14	4.69	No	Yes	0	8	8
17	R:R:K65	R:R:Y14	13.14	No	Yes	0	7	8
18	R:R:I66	R:R:Y14	3.63	No	Yes	0	7	8
19	R:R:V260	R:R:Y14	3.79	No	Yes	0	5	8
20	R:R:S263	R:R:Y14	3.82	No	Yes	0	6	8
21	R:R:I15	R:R:L19	4.28	No	No	0	6	4
22	R:R:I15	R:R:I66	5.89	No	No	0	6	7
23	R:R:I17	R:R:L264	4.28	No	No	0	7	5
24	R:R:F18	R:R:L19	4.87	Yes	No	0	7	4
25	R:R:F18	R:R:L22	7.31	Yes	No	0	7	6
26	R:R:F18	R:R:L62	4.87	Yes	No	0	7	8
27	R:R:F18	R:R:P63	8.67	Yes	No	0	7	9
28	R:R:G21	R:R:L59	3.42	No	No	0	8	6
29	R:R:L22	R:R:L59	5.54	No	No	0	6	6
30	R:R:A24	R:R:P270	3.74	No	No	0	7	9
31	R:R:N25	R:R:T52	5.85	No	Yes	0	9	8
32	R:R:L56	R:R:N25	13.73	No	No	0	7	9
33	R:R:A28	R:R:P270	3.74	No	No	0	8	9
34	R:R:L29	R:R:V33	2.98	No	No	0	7	4
35	R:R:L29	R:R:T52	5.9	No	Yes	0	7	8
36	R:R:L29	R:R:L53	4.15	No	No	0	7	6
37	R:R:F32	R:R:L48	10.96	No	No	0	7	8
38	R:R:F32	R:R:T52	5.19	No	Yes	0	7	8
39	R:R:G34	R:R:V33	3.68	No	No	0	4	4
40	R:R:Q38	R:R:R35	8.18	No	No	0	5	5
41	R:R:H45	R:R:R35	21.44	No	No	0	7	5
42	R:R:L49	R:R:V36	4.47	No	No	0	6	5
43	R:R:P39	R:R:Q38	3.16	No	No	0	3	5
44	R:R:P39	R:R:Q40	4.74	No	No	0	3	5
45	R:R:P123	R:R:P41	3.9	No	No	3	2	6
46	R:R:A42	R:R:H45	4.39	No	No	0	7	7
47	R:R:E106	R:R:P43	9.43	No	Yes	0	8	7
48	R:R:P43	R:R:R121	4.32	Yes	No	0	7	7
49	R:R:H45	R:R:V44	4.15	No	No	0	7	7
50	R:R:L48	R:R:V44	2.98	No	No	0	8	7
51	R:R:G126	R:R:I46	3.53	No	Yes	0	8	7
52	R:R:F273	R:R:L48	8.53	No	No	0	9	8
53	R:R:L99	R:R:S50	4.5	Yes	No	0	8	9
54	R:R:A130	R:R:S50	3.42	No	No	0	7	9
55	R:R:D55	R:R:L51	9.5	Yes	Yes	1	9	9
56	R:R:L51	R:R:S96	3	Yes	No	1	9	9
57	R:R:L51	R:R:L99	4.15	Yes	Yes	0	9	8
58	R:R:L100	R:R:L51	5.54	No	Yes	0	8	9
59	R:R:D269	R:R:L51	6.79	No	Yes	1	9	9
60	R:R:A54	R:R:C95	3.61	No	Yes	0	8	7
61	R:R:D55	R:R:S96	4.42	Yes	No	1	9	9
62	R:R:A266	R:R:D55	4.63	No	Yes	0	8	9
63	R:R:D269	R:R:D55	9.31	No	Yes	1	9	9
64	R:R:F89	R:R:L58	10.96	Yes	No	1	7	7
65	R:R:L58	R:R:S92	7.51	No	No	0	7	8
66	R:R:L58	R:R:S263	3	No	No	1	7	6
67	R:R:L61	R:R:T85	4.42	No	No	0	7	5
68	R:R:F64	R:R:T85	10.38	No	No	0	6	5
69	R:R:F89	R:R:K65	14.89	Yes	No	0	7	7
70	R:R:E68	R:R:F73	9.33	No	Yes	0	5	1
71	R:R:E68	R:R:W75	4.36	No	Yes	0	5	3
72	R:R:S71	R:R:Y76	5.09	No	No	0	4	4
73	R:R:F73	R:R:S256	5.28	Yes	No	2	1	4
74	R:R:R74	R:R:Y76	9.26	No	No	0	1	4
75	R:R:L77	R:R:W75	14.81	No	Yes	0	7	3
76	R:R:C82	R:R:W75	7.84	No	Yes	4	9	3
77	R:R:C164	R:R:W75	14.37	No	Yes	4	9	3
78	R:R:L77	R:R:P78	4.93	No	No	0	7	8
79	R:R:L77	R:R:V81	4.47	No	No	0	7	6
80	R:R:K79	R:R:Q148	6.78	No	No	0	2	5
81	R:R:C164	R:R:C82	7.28	No	No	4	9	9
82	R:R:A83	R:R:Q148	3.03	No	No	0	7	5
83	R:R:G86	R:R:T85	3.64	No	No	0	6	5
84	R:R:F87	R:R:G88	4.52	Yes	No	0	6	5
85	R:R:F87	R:R:S91	7.93	Yes	No	5	6	5
86	R:R:F138	R:R:F87	4.29	No	Yes	5	3	6
87	R:R:F87	R:R:I145	10.05	Yes	No	0	6	4
88	R:R:F89	R:R:Y90	5.16	Yes	Yes	1	7	5
89	R:R:F89	R:R:I93	3.77	Yes	No	0	7	8
90	R:R:F89	R:R:S263	5.28	Yes	No	1	7	6
91	R:R:Y165	R:R:Y90	7.94	Yes	Yes	1	4	5
92	R:R:Y238	R:R:Y90	8.94	Yes	Yes	1	7	5
93	R:R:R255	R:R:Y90	5.14	Yes	Yes	1	5	5
94	R:R:F138	R:R:S91	5.28	No	No	5	3	5
95	R:R:C141	R:R:S91	6.89	No	No	0	7	5
96	R:R:I93	R:R:S262	6.19	No	No	0	8	8
97	R:R:L183	R:R:Y94	7.03	No	Yes	0	5	8
98	R:R:L187	R:R:Y94	10.55	No	Yes	0	6	8
99	R:R:Y238	R:R:Y94	8.94	Yes	Yes	1	7	8
100	R:R:N239	R:R:Y94	5.81	Yes	Yes	1	8	8
101	R:R:H242	R:R:Y94	4.36	Yes	Yes	1	6	8
102	R:R:C95	R:R:L99	3.17	Yes	Yes	0	7	8
103	R:R:C95	R:R:W134	5.22	Yes	No	0	7	9
104	R:R:C95	R:R:S137	5.16	Yes	No	0	7	7
105	R:R:P191	R:R:T97	3.5	Yes	No	0	9	8
106	R:R:F231	R:R:T97	3.89	Yes	No	1	9	8
107	R:R:F235	R:R:T97	11.67	No	No	1	9	8
108	R:R:M136	R:R:W98	4.65	No	No	0	4	5
109	R:R:L187	R:R:W98	6.83	No	No	0	6	5
110	R:R:P191	R:R:W98	12.16	Yes	No	0	9	5
111	R:R:A133	R:R:L99	3.15	No	Yes	0	7	8
112	R:R:I103	R:R:R107	5.01	No	No	0	9	9
113	R:R:S104	R:R:T195	6.4	No	No	0	9	7
114	R:R:S104	R:R:Y199	12.72	No	Yes	0	9	8
115	R:R:I105	R:R:V194	3.07	Yes	No	0	6	6
116	R:R:C198	R:R:I105	3.27	No	Yes	0	8	6
117	R:R:E106	R:R:Y117	8.98	No	No	0	8	5
118	R:R:R107	R:R:Y199	7.2	No	Yes	0	9	8
119	R:R:F273	R:R:R107	4.28	No	No	0	9	9
120	R:R:A112	R:R:Y108	6.67	No	Yes	0	7	8
121	R:R:F197	R:R:Y108	4.13	No	Yes	6	5	8
122	R:R:C198	R:R:Y108	6.72	No	Yes	0	8	8
123	R:R:R201	R:R:Y108	7.2	No	Yes	6	4	8
124	R:R:G110	R:R:Y117	4.35	No	No	0	8	5
125	R:R:F202	R:R:V111	6.55	No	No	0	8	8
126	R:R:I205	R:R:V111	7.68	No	No	0	5	8
127	R:R:M206	R:R:V111	3.04	Yes	No	0	8	8
128	R:R:A112	R:R:F113	5.55	No	No	0	7	6
129	R:R:F113	R:R:Q116	11.71	No	No	0	6	5
130	R:R:L124	R:R:R122	15.79	No	No	0	3	6
131	R:R:R122	R:R:Y125	12.35	No	No	0	6	4
132	R:R:L131	R:R:V127	2.98	No	No	0	4	4
133	R:R:F138	R:R:W134	7.02	No	No	0	3	9
134	R:R:G139	R:R:T142	3.64	No	No	0	4	4
135	R:R:E182	R:R:H140	9.85	No	No	0	4	4
136	R:R:H140	R:R:L183	3.86	No	No	0	4	5
137	R:R:H140	R:R:L187	7.71	No	No	0	4	6
138	R:R:I143	R:R:V147	3.07	No	No	0	7	4
139	R:R:I143	R:R:V179	9.22	No	No	0	7	4
140	R:R:V144	R:R:Y165	10.09	No	Yes	0	5	4
141	R:R:V147	R:R:V176	3.21	No	Yes	0	4	4
142	R:R:Q148	R:R:Y165	3.38	No	Yes	0	5	4
143	R:R:E166	R:R:T163	5.64	No	No	0	5	4
144	R:R:E166	R:R:N167	5.26	No	No	0	5	4
145	R:R:F168	R:R:Q172	22.25	No	No	0	4	1
146	R:R:F168	R:R:V176	5.24	No	Yes	0	4	4
147	R:R:L177	R:R:V176	2.98	No	Yes	0	2	4
148	R:R:R180	R:R:V176	3.92	Yes	Yes	0	5	4
149	R:R:L177	R:R:R249	4.86	No	No	0	2	4
150	R:R:H242	R:R:R180	12.41	Yes	Yes	1	6	5
151	R:R:R180	R:R:R255	10.66	Yes	Yes	1	5	5
152	R:R:F246	R:R:L181	15.83	No	No	0	4	5
153	R:R:E182	R:R:V186	8.56	No	No	0	4	4
154	R:R:C184	R:R:F189	5.59	Yes	No	0	6	4
155	R:R:C184	R:R:N239	4.72	Yes	Yes	0	6	8
156	R:R:C184	R:R:H242	4.42	Yes	Yes	0	6	6
157	R:R:C184	R:R:L243	6.35	Yes	No	0	6	5
158	R:R:F188	R:R:F189	5.36	Yes	No	0	8	4
159	R:R:F188	R:R:M192	9.95	Yes	Yes	1	8	6
160	R:R:F188	R:R:F231	3.22	Yes	Yes	1	8	9
161	R:R:F188	R:R:N239	26.58	Yes	Yes	1	8	8
162	R:R:I190	R:R:P191	3.39	No	Yes	0	5	9
163	R:R:F231	R:R:M192	3.73	Yes	Yes	1	9	6
164	R:R:F231	R:R:T195	7.78	Yes	No	0	9	7
165	R:R:F197	R:R:R201	11.76	No	No	6	5	4
166	R:R:T227	R:R:Y199	11.24	No	Yes	0	7	8
167	R:R:L228	R:R:Y199	4.69	No	Yes	0	8	8
168	R:R:W200	R:R:W204	7.5	No	No	0	3	3
169	R:R:L207	R:R:V203	2.98	No	No	7	4	5
170	R:R:V203	R:R:V221	4.81	No	Yes	7	5	4
171	R:R:I205	R:R:Q209	4.12	No	No	0	5	5
172	R:R:M206	R:R:V212	3.04	Yes	Yes	0	8	3
173	R:R:A220	R:R:M206	3.22	No	Yes	0	7	8
174	R:R:M206	R:R:V221	3.04	Yes	Yes	0	8	4
175	R:R:L207	R:R:V221	2.98	No	Yes	7	4	4
176	R:R:P210	R:R:Q209	6.32	No	No	0	3	5
177	R:R:H211	R:R:P210	7.63	No	No	0	3	3
178	R:R:R216	R:R:V212	3.92	No	Yes	0	5	3
179	R:R:R216	R:R:R219	3.2	No	No	0	5	7
180	R:R:G222	R:R:V221	3.68	No	Yes	0	5	4
181	R:R:L272	R:R:T227	4.42	No	No	0	8	7
182	R:R:C234	R:R:N230	4.72	Yes	Yes	1	8	7
183	R:R:N230	R:R:N265	6.81	Yes	Yes	1	7	9
184	R:R:L268	R:R:N230	6.87	No	Yes	0	7	7
185	R:R:L272	R:R:N230	4.12	No	Yes	0	8	7
186	R:R:F231	R:R:F235	6.43	Yes	No	1	9	9
187	R:R:C234	R:R:L264	3.17	Yes	No	0	8	5
188	R:R:C234	R:R:N265	7.87	Yes	Yes	1	8	9
189	R:R:F235	R:R:N265	8.46	No	Yes	1	9	9
190	R:R:G236	R:R:P237	4.06	No	No	0	5	9
191	R:R:N239	R:R:Y238	4.65	Yes	Yes	1	8	7
192	R:R:H242	R:R:Y238	10.89	Yes	Yes	1	6	7
193	R:R:R255	R:R:Y238	6.17	Yes	Yes	1	5	7
194	R:R:S262	R:R:Y238	3.82	No	Yes	0	8	7
195	R:R:H242	R:R:S241	4.18	Yes	Yes	1	6	5
196	R:R:P252	R:R:S241	5.34	Yes	Yes	1	1	5
197	R:R:S241	R:R:W254	4.94	Yes	Yes	1	5	4
198	R:R:R255	R:R:S241	3.95	Yes	Yes	1	5	5
199	R:R:Q248	R:R:V244	5.73	No	No	0	3	5
200	R:R:V244	R:R:W254	6.13	No	Yes	0	5	4
201	R:R:G245	R:R:P252	4.06	No	Yes	0	5	1
202	R:R:P252	R:R:S251	3.56	Yes	No	0	1	4
203	R:R:P252	R:R:W254	4.05	Yes	Yes	1	1	4
204	R:R:P252	R:R:R255	7.21	Yes	Yes	1	1	5
205	R:R:W253	R:R:W254	11.25	No	Yes	0	1	4
206	R:R:L264	R:R:L268	4.15	No	No	0	5	7
207	R:R:D269	R:R:N265	13.46	No	Yes	1	9	9
208	R:R:L268	R:R:S267	4.5	No	No	0	7	8
209	R:R:I10	R:R:I257	2.94	Yes	No	0	5	5
210	R:R:I143	R:R:I146	2.94	No	No	0	7	4
211	R:R:G86	R:R:Y90	2.9	No	Yes	0	6	5
212	R:R:I103	R:R:L47	2.85	No	No	0	9	7
213	R:R:I105	R:R:L109	2.85	Yes	No	0	6	6
214	R:R:I128	R:R:L124	2.85	No	No	0	1	3
215	R:R:L232	R:R:M192	2.83	No	Yes	0	5	6
216	R:R:L181	R:R:L243	2.77	No	No	0	5	5
217	R:R:A224	R:R:F202	2.77	No	No	0	7	8
218	R:R:A224	R:R:Y199	2.67	No	Yes	0	7	8
219	R:R:F64	R:R:V81	2.62	No	No	0	6	6
220	R:R:F89	R:R:V259	2.62	Yes	No	0	7	5
221	R:R:R217	R:R:V212	2.62	No	Yes	0	6	3
222	R:R:A258	R:R:W254	2.59	No	Yes	0	7	4
223	R:R:F168	R:R:L173	2.44	No	No	0	4	1
224	R:R:F189	R:R:L185	2.44	No	No	0	4	5
225	R:R:T208	R:R:W204	2.43	No	No	0	4	3
226	R:R:G21	R:R:P23	2.03	No	No	0	8	4
227	R:R:G126	R:R:P43	2.03	No	Yes	0	8	7
228	R:R:A42	R:R:P43	1.87	No	Yes	0	7	7
229	R:R:A101	R:R:P191	1.87	No	Yes	0	8	9
230	R:R:A258	R:R:P237	1.87	No	No	0	7	9
231	R:R:G213	R:R:V212	1.84	No	Yes	0	3	3
232	R:R:G102	R:R:I105	1.76	No	Yes	0	6	6
233	R:R:C198	R:R:S104	1.72	No	No	0	8	9
234	R:R:C234	R:R:V233	1.71	Yes	No	0	8	5
235	R:R:A13	R:R:V260	1.7	No	No	0	4	5
236	R:R:I46	R:R:P41	1.69	Yes	No	3	7	6
237	R:R:I46	R:R:P123	1.69	Yes	No	3	7	2
238	R:R:I80	R:R:P78	1.69	No	No	0	4	8
239	R:R:A28	R:R:T52	1.68	No	Yes	0	8	8
240	R:R:L177	R:R:P178	1.64	No	No	0	2	2
241	R:R:A69	R:R:I10	1.62	No	Yes	0	5	5
242	R:R:V203	R:R:V225	1.6	No	No	0	5	5
243	R:R:V240	R:R:V244	1.6	No	No	0	6	5
244	R:R:A70	R:R:L11	1.58	No	No	0	4	5
245	R:R:A24	R:R:L271	1.58	No	No	0	7	7
246	R:R:A129	R:R:L47	1.58	No	No	0	5	7
247	R:R:I46	R:R:V127	1.54	Yes	No	0	7	4
248	R:R:I16	R:R:T20	1.52	No	No	0	5	5
249	R:R:I146	R:R:T142	1.52	No	No	0	4	4
250	R:R:L49	R:R:V33	1.49	No	No	0	6	4
251	R:R:L119	R:R:V115	1.49	No	No	0	4	6
252	R:R:L223	R:R:V226	1.49	No	No	0	7	5
253	R:R:L272	R:R:V226	1.49	No	No	0	8	5
254	R:R:I196	R:R:M192	1.46	No	Yes	0	4	6
255	R:R:D170	R:R:T169	1.45	No	No	0	1	4
256	R:R:F113	R:R:P114	1.44	No	No	0	6	8
257	R:R:P123	R:R:R122	1.44	No	No	0	2	6
258	R:R:F261	R:R:P237	1.44	No	No	0	7	9
259	R:R:I80	R:R:L84	1.43	No	No	0	4	5
260	R:R:Q116	R:R:V115	1.43	No	No	0	5	6
261	R:R:L57	R:R:L61	1.38	No	No	0	7	7
262	R:R:L60	R:R:L61	1.38	No	No	0	4	7
263	R:R:D174	R:R:L173	1.36	No	No	0	1	1
264	R:R:L27	R:R:R30	1.21	No	No	0	6	4
265	R:R:L27	R:R:Y274	1.17	No	No	0	6	7
266	R:R:K250	R:R:W253	1.16	No	No	0	2	1
267	R:R:Q248	R:R:Y247	1.13	No	No	0	3	4
268	R:R:R201	R:R:W200	1	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.58571	7	1	0
2	R:R:I10	3.17	4	2	5
3	R:R:Y14	5.814	5	0	8
4	R:R:F18	6.43	4	0	7
5	R:R:P43	4.4125	4	0	7
6	R:R:I46	2.1125	4	3	7
7	R:R:L51	5.796	5	1	9
8	R:R:T52	4.655	4	0	8
9	R:R:D55	6.965	4	1	9
10	R:R:F73	5.8975	4	2	1
11	R:R:W75	10.345	4	4	3
12	R:R:F87	6.6975	4	5	6
13	R:R:F89	7.11333	6	1	7
14	R:R:Y90	7.56833	6	1	5
15	R:R:Y94	7.338	5	1	8
16	R:R:C95	4.29	4	0	7
17	R:R:L99	3.7425	4	0	8
18	R:R:I105	2.7375	4	0	6
19	R:R:Y108	6.18	4	6	8
20	R:R:Y165	8.8025	4	1	4
21	R:R:V176	3.8375	4	0	4
22	R:R:R180	8.7325	4	1	5
23	R:R:C184	5.27	4	0	6
24	R:R:F188	11.2775	4	1	8
25	R:R:P191	5.23	4	0	9
26	R:R:M192	4.4925	4	1	6
27	R:R:Y199	7.704	5	0	8
28	R:R:M206	3.085	4	0	8
29	R:R:V212	2.855	4	0	3
30	R:R:V221	3.6275	4	7	4
31	R:R:N230	5.63	4	1	7
32	R:R:F231	5.01	5	1	9
33	R:R:C234	4.3675	4	1	8
34	R:R:Y238	7.29571	7	1	7
35	R:R:N239	10.44	4	1	8
36	R:R:S241	4.6025	4	1	5
37	R:R:H242	6.60333	6	1	6
38	R:R:P252	4.844	5	1	1
39	R:R:W254	5.792	5	1	4
40	R:R:R255	6.31667	6	1	5
41	R:R:N265	9.15	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G86	R:R:Y90	21.2084	2.9	No	Yes	0	6	5
2	R:R:G86	R:R:T85	20.5464	3.64	No	No	0	6	5
3	R:R:F64	R:R:T85	17.5287	10.38	No	No	0	6	5
4	R:R:F64	R:R:V81	16.8278	2.62	No	No	0	6	6
5	R:R:L77	R:R:V81	16.0393	4.47	No	No	0	7	6
6	R:R:L77	R:R:W75	12.8074	14.81	No	Yes	0	7	3
7	R:R:E68	R:R:W75	10.3154	4.36	No	Yes	0	5	3
8	R:R:F89	R:R:Y90	27.2049	5.16	Yes	Yes	1	7	5
9	R:R:F89	R:R:K65	11.9962	14.89	Yes	No	0	7	7
10	R:R:K65	R:R:Y14	11.2986	13.14	No	Yes	0	7	8
11	R:R:L62	R:R:Y14	13.2358	4.69	No	Yes	0	8	8
12	R:R:F89	R:R:S263	12.1228	5.28	Yes	No	1	7	6
13	R:R:S263	R:R:Y14	11.4446	3.82	No	Yes	0	6	8
14	R:R:F18	R:R:L62	11.6036	4.87	Yes	No	0	7	8
15	R:R:N239	R:R:Y238	64.8225	4.65	Yes	Yes	1	8	7
16	R:R:F188	R:R:N239	90.0383	26.58	Yes	Yes	1	8	8
17	R:R:F188	R:R:F231	100	3.22	Yes	Yes	1	8	9
18	R:R:F231	R:R:F235	29.8786	6.43	Yes	No	1	9	9
19	R:R:F235	R:R:N265	29.9403	8.46	No	Yes	1	9	9
20	R:R:F231	R:R:T195	76.2055	7.78	Yes	No	0	9	7
21	R:R:S104	R:R:T195	75.4786	6.4	No	No	0	9	7
22	R:R:S104	R:R:Y199	62.0417	12.72	No	Yes	0	9	8
23	R:R:R107	R:R:Y199	47.7448	7.2	No	Yes	0	9	8
24	R:R:F273	R:R:R107	43.825	4.28	No	No	0	9	9
25	R:R:F273	R:R:L48	42.8808	8.53	No	No	0	9	8
26	R:R:F32	R:R:L48	17.3957	10.96	No	No	0	7	8
27	R:R:F32	R:R:T52	16.1951	5.19	No	Yes	0	7	8
28	R:R:L48	R:R:V44	26.5397	2.98	No	No	0	8	7
29	R:R:H45	R:R:V44	25.391	4.15	No	No	0	7	7
30	R:R:A42	R:R:H45	19.6573	4.39	No	No	0	7	7
31	R:R:A42	R:R:P43	18.4697	1.87	No	Yes	0	7	7
32	R:R:G126	R:R:P43	12.5544	2.03	No	Yes	0	8	7
33	R:R:G126	R:R:I46	11.3278	3.53	No	Yes	0	8	7
34	R:R:D269	R:R:N265	24.9335	13.46	No	Yes	1	9	9
35	R:R:D269	R:R:L51	20.2252	6.79	No	Yes	1	9	9
36	R:R:L51	R:R:L99	16.87	4.15	Yes	Yes	0	9	8
37	R:R:C95	R:R:L99	12.1585	3.17	Yes	Yes	0	7	8
38	R:R:H242	R:R:Y94	12.5965	4.36	Yes	Yes	1	6	8
39	R:R:C198	R:R:S104	21.0656	1.72	No	No	0	8	9
40	R:R:C198	R:R:Y108	15.1437	6.72	No	Yes	0	8	8
41	R:R:A224	R:R:Y199	22.9833	2.67	No	Yes	0	7	8
42	R:R:A224	R:R:F202	21.919	2.77	No	No	0	7	8
43	R:R:F202	R:R:V111	20.7411	6.55	No	No	0	8	8
44	R:R:M206	R:R:V111	14.8582	3.04	Yes	No	0	8	8
45	R:R:R180	R:R:V176	42.1637	3.92	Yes	Yes	0	5	4
46	R:R:V147	R:R:V176	18.0446	3.21	No	Yes	0	4	4
47	R:R:I143	R:R:V147	15.3092	3.07	No	No	0	7	4
48	R:R:F168	R:R:V176	12.2623	5.24	No	Yes	0	4	4
49	R:R:C184	R:R:H242	25.7479	4.42	Yes	Yes	0	6	6
50	R:R:C184	R:R:F189	14.3682	5.59	Yes	No	0	6	4
51	R:R:N230	R:R:N265	10.3349	6.81	Yes	Yes	1	7	9
52	R:R:H242	R:R:S241	21.2214	4.18	Yes	Yes	1	6	5
53	R:R:S241	R:R:W254	27.1595	4.94	Yes	Yes	1	5	4
54	R:R:A258	R:R:W254	12.7847	2.59	No	Yes	0	7	4
55	R:R:V244	R:R:W254	12.8464	6.13	No	Yes	0	5	4
56	R:R:H242	R:R:Y238	12.8756	10.89	Yes	Yes	1	6	7
57	R:R:Y238	R:R:Y90	30.6801	8.94	Yes	Yes	1	7	5
58	R:R:R180	R:R:R255	10.3316	10.66	Yes	Yes	1	5	5
59	R:R:C184	R:R:N239	14.2968	4.72	Yes	Yes	0	6	8
60	R:R:F188	R:R:F189	13.9918	5.36	Yes	No	0	8	4
61	R:R:H242	R:R:R180	25.232	12.41	Yes	Yes	1	6	5
62	R:R:N239	R:R:Y94	14.2968	5.81	Yes	Yes	1	8	8
63	R:R:R255	R:R:Y238	17.188	6.17	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y90	15.33	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y165	13.8	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R180	7.94	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L183	7.24	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y238	7.66	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:H242	3.36	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R255	4.77	1	Yes	Yes	0	5	0	1
R:R:F89	R:R:Y90	5.16	1	Yes	Yes	7	5	2	1
R:R:Y165	R:R:Y90	7.94	1	Yes	Yes	4	5	1	1
R:R:Y238	R:R:Y90	8.94	1	Yes	Yes	7	5	1	1
R:R:R255	R:R:Y90	5.14	1	Yes	Yes	5	5	1	1
R:R:L183	R:R:Y94	7.03	0	No	Yes	5	8	1	2
R:R:Y238	R:R:Y94	8.94	1	Yes	Yes	7	8	1	2
R:R:N239	R:R:Y94	5.81	1	Yes	Yes	8	8	2	2
R:R:H242	R:R:Y94	4.36	1	Yes	Yes	6	8	1	2
R:R:H140	R:R:L183	3.86	0	No	No	4	5	2	1
R:R:V144	R:R:Y165	10.09	0	No	Yes	5	4	2	1
R:R:Q148	R:R:Y165	3.38	0	No	Yes	5	4	2	1
R:R:R180	R:R:V176	3.92	1	Yes	Yes	5	4	1	2
R:R:H242	R:R:R180	12.41	1	Yes	Yes	6	5	1	1
R:R:R180	R:R:R255	10.66	1	Yes	Yes	5	5	1	1
R:R:C184	R:R:N239	4.72	0	Yes	Yes	6	8	2	2
R:R:C184	R:R:H242	4.42	0	Yes	Yes	6	6	2	1
R:R:N239	R:R:Y238	4.65	1	Yes	Yes	8	7	2	1
R:R:H242	R:R:Y238	10.89	1	Yes	Yes	6	7	1	1
R:R:R255	R:R:Y238	6.17	1	Yes	Yes	5	7	1	1
R:R:S262	R:R:Y238	3.82	0	No	Yes	8	7	2	1
R:R:H242	R:R:S241	4.18	1	Yes	Yes	6	5	1	2
R:R:P252	R:R:S241	5.34	1	Yes	Yes	1	5	2	2
R:R:R255	R:R:S241	3.95	1	Yes	Yes	5	5	1	2
R:R:P252	R:R:R255	7.21	1	Yes	Yes	1	5	2	1
R:R:G86	R:R:Y90	2.9	0	No	Yes	6	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8J24_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	241
Number of Links	268
Number of Hubs	41
Number of Links mediated by Hubs	145
Number of Communities	7
Number of Nodes involved in Communities	45
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	50753
Length Of Smallest Path	3
Average Path Length	14.02
Length of Longest Path	33
Minimum Path Strength	1.19
Average Path Strength	6.74818
Maximum Path Strength	18.265
Minimum Path Correlation	0.71
Average Path Correlation	0.915897
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	43.981
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.0519
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ACT
Name	Acetate
Synonyms	Acetate anion
Identifier
Formula	C2 H3 O2
Molecular Weight	59.044
SMILES
PubChem	175
Formal Charge	-1
Total Atoms	7
Total Chiral Atoms	0
Total Bonds	6
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>8J24_nogp_Chain_R D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R V R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N F R W Y L P K I V C A L T G F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q T C Y E N F T D E Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L T Q P H V G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G F Y Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187	Gi1/β1/γ2	3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187		3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729	Gi1/β1/γ2	3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729		3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	8Y6W	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	Gi1/β1/γ2	3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6W (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	9CLW	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CLW (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	-	Gi1/β1/γ2	3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	-		3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8Y6Y	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	GLPG0974	-	-	3.36	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8J24_nogp.zip

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