psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D4	R:R:K6	5.53	No	Yes	0	4	5
2	R:R:D4	R:R:S7	5.89	No	No	0	4	3
3	R:R:S8	R:R:W5	3.71	No	No	0	5	7
4	R:R:K6	R:R:W253	3.48	Yes	No	0	5	1
5	R:R:K6	R:R:S256	3.06	Yes	No	4	5	4
6	R:R:I257	R:R:K6	4.36	No	Yes	4	5	5
7	R:R:N72	R:R:S7	8.94	No	No	0	3	3
8	R:R:L9	R:R:S8	4.5	No	No	0	6	5
9	R:R:I10	R:R:V260	4.61	No	No	0	5	5
10	R:R:I16	R:R:M12	2.92	No	No	0	5	5
11	R:R:K65	R:R:Y14	9.55	No	No	0	7	8
12	R:R:I66	R:R:Y14	3.63	No	No	0	7	8
13	R:R:V260	R:R:Y14	6.31	No	No	0	5	8
14	R:R:I15	R:R:L19	2.85	No	No	0	6	4
15	R:R:I16	R:R:I17	2.94	No	Yes	0	5	7
16	R:R:I17	R:R:L62	2.85	Yes	Yes	0	7	8
17	R:R:I17	R:R:L264	2.85	Yes	No	0	7	5
18	R:R:I17	R:R:S267	7.74	Yes	No	0	7	8
19	R:R:F18	R:R:L22	3.65	No	Yes	0	7	6
20	R:R:L22	R:R:L26	5.54	Yes	No	0	6	4
21	R:R:L22	R:R:L59	4.15	Yes	No	0	6	6
22	R:R:N25	R:R:T52	2.92	Yes	No	0	9	8
23	R:R:D55	R:R:N25	6.73	Yes	Yes	0	9	9
24	R:R:L56	R:R:N25	4.12	No	Yes	0	7	9
25	R:R:N25	R:R:P270	8.15	Yes	No	0	9	9
26	R:R:A28	R:R:F32	2.77	No	Yes	0	8	7
27	R:R:A28	R:R:Y274	4	No	No	0	8	7
28	R:R:L29	R:R:T52	2.95	No	No	0	7	8
29	R:R:L29	R:R:L53	4.15	No	No	0	7	6
30	R:R:F32	R:R:L48	10.96	Yes	Yes	0	7	8
31	R:R:F32	R:R:T52	5.19	Yes	No	0	7	8
32	R:R:Q38	R:R:R35	7.01	No	No	0	5	5
33	R:R:H45	R:R:R35	21.44	No	No	0	7	5
34	R:R:L49	R:R:V36	2.98	No	No	0	6	5
35	R:R:P39	R:R:Q38	3.16	No	No	0	3	5
36	R:R:P123	R:R:P41	3.9	No	No	0	2	6
37	R:R:A42	R:R:H45	2.93	No	No	0	7	7
38	R:R:P43	R:R:R121	5.76	No	No	0	7	7
39	R:R:L48	R:R:V44	2.98	Yes	No	0	8	7
40	R:R:E106	R:R:V44	2.85	No	No	0	8	7
41	R:R:G126	R:R:I46	5.29	No	No	0	8	7
42	R:R:L47	R:R:L99	2.77	No	Yes	0	7	8
43	R:R:I103	R:R:L48	4.28	No	Yes	0	9	8
44	R:R:F273	R:R:L48	8.53	Yes	Yes	0	9	8
45	R:R:L99	R:R:S50	6.01	Yes	No	0	8	9
46	R:R:A130	R:R:S50	3.42	No	No	0	7	9
47	R:R:D55	R:R:L51	5.43	Yes	Yes	2	9	9
48	R:R:L51	R:R:S96	3	Yes	No	2	9	9
49	R:R:L51	R:R:L99	2.77	Yes	Yes	0	9	8
50	R:R:F273	R:R:L51	3.65	Yes	Yes	0	9	9
51	R:R:A54	R:R:C95	3.61	No	Yes	0	8	7
52	R:R:D55	R:R:S96	4.42	Yes	No	2	9	9
53	R:R:A266	R:R:D55	4.63	No	Yes	0	8	9
54	R:R:L56	R:R:L60	5.54	No	No	0	7	4
55	R:R:L57	R:R:L61	5.54	No	No	0	7	7
56	R:R:L57	R:R:S92	4.5	No	No	0	7	8
57	R:R:L58	R:R:L62	2.77	Yes	Yes	3	7	8
58	R:R:F89	R:R:L58	15.83	Yes	Yes	3	7	7
59	R:R:L58	R:R:S92	6.01	Yes	No	0	7	8
60	R:R:I93	R:R:L58	2.85	No	Yes	0	8	7
61	R:R:L58	R:R:S263	3	Yes	No	3	7	6
62	R:R:F64	R:R:L61	4.87	No	No	0	6	7
63	R:R:F89	R:R:L62	3.65	Yes	Yes	3	7	8
64	R:R:F64	R:R:W75	4.01	No	Yes	0	6	9
65	R:R:F64	R:R:T85	7.78	No	No	0	6	5
66	R:R:F89	R:R:K65	7.44	Yes	No	0	7	7
67	R:R:I67	R:R:W75	8.22	No	Yes	0	4	9
68	R:R:E68	R:R:F73	5.83	No	No	0	5	4
69	R:R:E68	R:R:W75	13.08	No	Yes	0	5	9
70	R:R:C164	R:R:E68	6.08	No	No	0	9	5
71	R:R:F73	R:R:T163	7.78	No	No	0	4	4
72	R:R:L77	R:R:W75	7.97	No	Yes	0	7	9
73	R:R:L77	R:R:P78	4.93	No	No	0	7	8
74	R:R:L77	R:R:V81	4.47	No	No	0	7	6
75	R:R:F138	R:R:F87	6.43	No	Yes	0	3	6
76	R:R:C141	R:R:F87	6.98	No	Yes	0	7	6
77	R:R:F87	R:R:I145	6.28	Yes	No	0	6	4
78	R:R:G88	R:R:S91	3.71	No	No	0	5	5
79	R:R:F89	R:R:S263	3.96	Yes	No	3	7	6
80	R:R:Y165	R:R:Y90	4.96	No	No	1	4	5
81	R:R:Y238	R:R:Y90	11.91	Yes	No	1	7	5
82	R:R:R255	R:R:Y90	4.12	Yes	No	1	5	5
83	R:R:F138	R:R:S91	6.61	No	No	0	3	5
84	R:R:I93	R:R:Y94	4.84	No	Yes	0	8	8
85	R:R:I93	R:R:S262	6.19	No	No	0	8	8
86	R:R:L183	R:R:Y94	10.55	No	Yes	1	5	8
87	R:R:L187	R:R:Y94	14.07	Yes	Yes	1	6	8
88	R:R:Y238	R:R:Y94	5.96	Yes	Yes	1	7	8
89	R:R:N239	R:R:Y94	5.81	No	Yes	1	8	8
90	R:R:H242	R:R:Y94	3.27	Yes	Yes	1	6	8
91	R:R:C95	R:R:L99	3.17	Yes	Yes	0	7	8
92	R:R:C95	R:R:W134	11.75	Yes	No	0	7	9
93	R:R:C95	R:R:S137	5.16	Yes	No	0	7	7
94	R:R:F235	R:R:S96	5.28	Yes	No	2	9	9
95	R:R:P191	R:R:T97	3.5	Yes	No	0	9	8
96	R:R:F231	R:R:T97	6.49	Yes	No	2	9	8
97	R:R:F235	R:R:T97	7.78	Yes	No	2	9	8
98	R:R:L187	R:R:W98	3.42	Yes	No	0	6	5
99	R:R:P191	R:R:W98	14.86	Yes	No	0	9	5
100	R:R:A133	R:R:L99	3.15	No	Yes	0	7	8
101	R:R:F231	R:R:L100	4.87	Yes	No	0	9	8
102	R:R:D269	R:R:L100	6.79	No	No	0	9	8
103	R:R:I103	R:R:R107	7.52	No	Yes	0	9	9
104	R:R:S104	R:R:T195	6.4	No	No	0	9	7
105	R:R:S104	R:R:Y199	15.26	No	Yes	0	9	8
106	R:R:I105	R:R:L109	2.85	No	No	0	6	6
107	R:R:C198	R:R:I105	3.27	No	No	0	8	6
108	R:R:E106	R:R:Y117	5.61	No	No	0	8	5
109	R:R:R107	R:R:Y199	9.26	Yes	Yes	5	9	8
110	R:R:R107	R:R:T227	3.88	Yes	No	5	9	7
111	R:R:F273	R:R:R107	4.28	Yes	Yes	0	9	9
112	R:R:A112	R:R:Y108	5.34	No	Yes	6	7	8
113	R:R:F113	R:R:Y108	3.09	Yes	Yes	6	6	8
114	R:R:C198	R:R:Y108	8.06	No	Yes	0	8	8
115	R:R:R201	R:R:Y108	17.49	No	Yes	0	4	8
116	R:R:G110	R:R:Y117	5.79	No	No	0	8	5
117	R:R:F202	R:R:V111	5.24	No	No	0	8	8
118	R:R:I205	R:R:V111	3.07	No	No	0	5	8
119	R:R:A112	R:R:F113	5.55	No	Yes	6	7	6
120	R:R:F113	R:R:Q116	4.68	Yes	No	0	6	5
121	R:R:R121	R:R:Y117	6.17	No	No	0	7	5
122	R:R:R122	R:R:Y125	10.29	No	No	0	6	4
123	R:R:I128	R:R:L124	5.71	No	No	0	1	3
124	R:R:F138	R:R:W134	6.01	No	No	0	3	9
125	R:R:H140	R:R:M136	3.94	No	No	0	4	4
126	R:R:H140	R:R:L187	5.14	No	Yes	0	4	6
127	R:R:Q148	R:R:V144	5.73	No	No	0	5	5
128	R:R:V144	R:R:V179	3.21	No	No	0	5	4
129	R:R:L183	R:R:V144	2.98	No	No	0	5	5
130	R:R:F168	R:R:Q148	3.51	No	No	0	4	5
131	R:R:E166	R:R:T163	8.47	No	No	0	5	4
132	R:R:F168	R:R:Y165	5.16	No	No	0	4	4
133	R:R:R255	R:R:Y165	5.14	Yes	No	1	5	4
134	R:R:F168	R:R:V176	5.24	No	Yes	0	4	4
135	R:R:E171	R:R:T169	12.7	No	No	0	3	4
136	R:R:Q172	R:R:T169	2.83	No	No	0	1	4
137	R:R:R180	R:R:V176	3.92	No	Yes	0	5	4
138	R:R:L177	R:R:R180	7.29	Yes	No	0	2	5
139	R:R:H242	R:R:R180	7.9	Yes	No	0	6	5
140	R:R:L181	R:R:L185	4.15	No	No	0	5	5
141	R:R:F246	R:R:L181	6.09	No	No	0	4	5
142	R:R:E182	R:R:V186	4.28	No	No	0	4	4
143	R:R:L183	R:R:L187	5.54	No	Yes	1	5	6
144	R:R:C184	R:R:F189	2.79	No	Yes	1	6	4
145	R:R:C184	R:R:H242	5.9	No	Yes	1	6	6
146	R:R:C184	R:R:L243	3.17	No	No	1	6	5
147	R:R:F189	R:R:L185	3.65	Yes	No	0	4	5
148	R:R:I190	R:R:V186	4.61	No	No	0	5	4
149	R:R:F188	R:R:F189	5.36	Yes	Yes	0	8	4
150	R:R:F188	R:R:M192	3.73	Yes	No	0	8	6
151	R:R:F188	R:R:F235	3.22	Yes	Yes	0	8	9
152	R:R:F188	R:R:N239	18.12	Yes	No	0	8	8
153	R:R:F189	R:R:L243	7.31	Yes	No	1	4	5
154	R:R:I190	R:R:P191	3.39	No	Yes	0	5	9
155	R:R:I196	R:R:M192	2.92	No	No	0	4	6
156	R:R:L232	R:R:M192	4.24	No	No	0	5	6
157	R:R:F231	R:R:T195	5.19	Yes	No	0	9	7
158	R:R:I196	R:R:L228	2.85	No	No	0	4	8
159	R:R:F197	R:R:R201	9.62	No	No	0	5	4
160	R:R:T227	R:R:Y199	8.74	No	Yes	5	7	8
161	R:R:L228	R:R:Y199	4.69	No	Yes	0	8	8
162	R:R:A224	R:R:F202	2.77	No	No	0	7	8
163	R:R:V203	R:R:V221	3.21	No	No	0	5	4
164	R:R:L207	R:R:V221	2.98	No	No	0	4	4
165	R:R:P210	R:R:Q209	7.9	No	No	0	3	5
166	R:R:Q209	R:R:V212	2.87	No	No	0	5	3
167	R:R:H211	R:R:P210	4.58	No	No	0	3	3
168	R:R:R217	R:R:V212	9.15	No	No	0	6	3
169	R:R:G213	R:R:R216	7.51	No	No	0	4	5
170	R:R:Q215	R:R:R218	5.84	No	No	0	4	5
171	R:R:F275	R:R:R219	7.48	No	No	0	7	7
172	R:R:G222	R:R:V221	3.68	No	No	0	5	4
173	R:R:L272	R:R:V226	4.47	Yes	No	0	8	5
174	R:R:L272	R:R:T227	2.95	Yes	No	0	8	7
175	R:R:L228	R:R:L232	2.77	No	No	0	8	5
176	R:R:C234	R:R:N230	3.15	No	No	0	8	7
177	R:R:L268	R:R:N230	6.87	No	No	0	7	7
178	R:R:F231	R:R:F235	5.36	Yes	Yes	2	9	9
179	R:R:C234	R:R:N265	7.87	No	No	0	8	9
180	R:R:F235	R:R:N265	12.08	Yes	No	0	9	9
181	R:R:G236	R:R:P237	4.06	No	No	0	5	9
182	R:R:F261	R:R:P237	5.78	No	No	0	7	9
183	R:R:N239	R:R:Y238	5.81	No	Yes	1	8	7
184	R:R:H242	R:R:Y238	7.62	Yes	Yes	1	6	7
185	R:R:R255	R:R:Y238	4.12	Yes	Yes	1	5	7
186	R:R:P252	R:R:S241	7.13	No	No	1	1	5
187	R:R:S241	R:R:W254	4.94	No	Yes	0	5	4
188	R:R:R255	R:R:S241	3.95	Yes	No	1	5	5
189	R:R:V244	R:R:W254	3.68	No	Yes	0	5	4
190	R:R:P252	R:R:S251	3.56	No	No	0	1	4
191	R:R:P252	R:R:R255	8.65	No	Yes	1	1	5
192	R:R:W253	R:R:W254	8.43	No	Yes	0	1	4
193	R:R:I257	R:R:S256	3.1	No	No	4	5	4
194	R:R:S262	R:R:V259	3.23	No	No	0	8	5
195	R:R:L264	R:R:L268	5.54	No	No	0	5	7
196	R:R:D269	R:R:N265	14.81	No	No	0	9	9
197	R:R:F273	R:R:L272	3.65	Yes	Yes	0	9	8
198	R:R:A24	R:R:Y274	2.67	No	No	0	7	7
199	R:R:A224	R:R:Y199	2.67	No	Yes	0	7	8
200	R:R:R74	R:R:S71	2.64	No	No	0	4	4
201	R:R:E166	R:R:N167	2.63	No	No	0	5	4
202	R:R:R30	R:R:V33	2.62	No	Yes	0	4	4
203	R:R:R216	R:R:V212	2.62	No	No	0	5	3
204	R:R:F87	R:R:T142	2.59	Yes	No	0	6	4
205	R:R:A258	R:R:W254	2.59	No	Yes	0	7	4
206	R:R:F261	R:R:I257	2.51	No	No	0	7	5
207	R:R:F202	R:R:M206	2.49	No	No	0	8	8
208	R:R:K118	R:R:R121	2.48	No	No	0	4	7
209	R:R:F18	R:R:L19	2.44	No	No	0	7	4
210	R:R:F32	R:R:L49	2.44	Yes	No	0	7	6
211	R:R:F275	R:R:L223	2.44	No	No	0	7	7
212	R:R:L207	R:R:R217	2.43	No	No	0	4	6
213	R:R:I205	R:R:W204	2.35	No	No	0	5	3
214	R:R:Q215	R:R:R219	2.34	No	No	0	4	7
215	R:R:L271	R:R:Y274	2.34	No	No	0	7	7
216	R:R:G126	R:R:P43	2.03	No	No	0	8	7
217	R:R:A24	R:R:G21	1.95	No	No	0	7	8
218	R:R:A129	R:R:G126	1.95	No	No	0	5	8
219	R:R:A42	R:R:P43	1.87	No	No	0	7	7
220	R:R:A101	R:R:P191	1.87	No	Yes	0	8	9
221	R:R:W200	R:R:W204	1.87	No	No	0	3	3
222	R:R:G34	R:R:V33	1.84	No	Yes	0	4	4
223	R:R:G236	R:R:V240	1.84	No	No	0	5	6
224	R:R:G21	R:R:T20	1.82	No	No	0	8	5
225	R:R:G86	R:R:T85	1.82	No	No	0	6	5
226	R:R:G139	R:R:T142	1.82	No	No	0	4	4
227	R:R:G102	R:R:I105	1.76	No	No	0	6	6
228	R:R:C198	R:R:S104	1.72	No	No	0	8	9
229	R:R:G21	R:R:L59	1.71	No	No	0	8	6
230	R:R:A70	R:R:S71	1.71	No	No	0	4	4
231	R:R:G245	R:R:L177	1.71	No	Yes	0	5	2
232	R:R:C234	R:R:V233	1.71	No	No	0	8	5
233	R:R:A13	R:R:V260	1.7	No	No	0	4	5
234	R:R:A101	R:R:V194	1.7	No	No	0	8	6
235	R:R:A224	R:R:V203	1.7	No	No	0	7	5
236	R:R:I46	R:R:P123	1.69	No	No	0	7	2
237	R:R:I80	R:R:P78	1.69	No	No	0	4	8
238	R:R:L22	R:R:P23	1.64	Yes	No	0	6	4
239	R:R:L62	R:R:P63	1.64	Yes	No	0	8	9
240	R:R:L177	R:R:P178	1.64	Yes	No	0	2	2
241	R:R:A69	R:R:I10	1.62	No	No	0	5	5
242	R:R:A83	R:R:I145	1.62	No	No	0	7	4
243	R:R:A83	R:R:K79	1.61	No	No	0	7	2
244	R:R:A220	R:R:M206	1.61	No	No	0	7	8
245	R:R:V147	R:R:V175	1.6	Yes	No	0	4	3
246	R:R:V147	R:R:V176	1.6	Yes	Yes	0	4	4
247	R:R:V147	R:R:V179	1.6	Yes	No	0	4	4
248	R:R:A69	R:R:L11	1.58	No	No	0	5	5
249	R:R:P39	R:R:Q40	1.58	No	No	0	3	5
250	R:R:P41	R:R:Q40	1.58	No	No	0	6	5
251	R:R:I46	R:R:V127	1.54	No	No	0	7	4
252	R:R:I128	R:R:V132	1.54	No	No	0	1	4
253	R:R:I146	R:R:V147	1.54	No	Yes	0	4	4
254	R:R:M136	R:R:V132	1.52	No	No	0	4	4
255	R:R:G34	R:R:R37	1.5	No	No	0	4	5
256	R:R:L29	R:R:V33	1.49	No	Yes	0	7	4
257	R:R:L49	R:R:V33	1.49	No	Yes	0	6	4
258	R:R:L131	R:R:V127	1.49	No	No	0	4	4
259	R:R:F113	R:R:P114	1.44	Yes	No	0	6	8
260	R:R:P123	R:R:R122	1.44	No	No	0	2	6
261	R:R:Q172	R:R:V176	1.43	No	Yes	0	1	4
262	R:R:L173	R:R:L177	1.38	No	Yes	0	1	2
263	R:R:L223	R:R:L272	1.38	No	Yes	0	7	8
264	R:R:D170	R:R:L173	1.36	No	No	0	1	1
265	R:R:Q248	R:R:Y247	1.13	No	No	0	3	4
266	R:R:F246	R:R:R249	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K6	4.1075	4	4	5
2	R:R:I17	4.095	4	0	7
3	R:R:L22	3.745	4	0	6
4	R:R:N25	5.48	4	0	9
5	R:R:F32	5.34	4	0	7
6	R:R:V33	1.86	4	0	4
7	R:R:L48	6.6875	4	0	8
8	R:R:L51	3.7125	4	2	9
9	R:R:D55	5.3025	4	2	9
10	R:R:L58	6.092	5	3	7
11	R:R:L62	2.7275	4	3	8
12	R:R:W75	8.32	4	0	9
13	R:R:F87	5.57	4	0	6
14	R:R:F89	7.72	4	3	7
15	R:R:Y94	7.41667	6	1	8
16	R:R:C95	5.9225	4	0	7
17	R:R:L99	3.574	5	0	8
18	R:R:R107	6.235	4	5	9
19	R:R:Y108	8.495	4	6	8
20	R:R:F113	3.69	4	6	6
21	R:R:V147	1.585	4	0	4
22	R:R:V176	3.0475	4	0	4
23	R:R:L177	3.005	4	0	2
24	R:R:L187	7.0425	4	1	6
25	R:R:F188	7.6075	4	0	8
26	R:R:F189	4.7775	4	1	4
27	R:R:P191	5.905	4	0	9
28	R:R:Y199	8.124	5	5	8
29	R:R:F231	5.4775	4	2	9
30	R:R:F235	6.744	5	2	9
31	R:R:Y238	7.084	5	1	7
32	R:R:H242	6.1725	4	1	6
33	R:R:W254	4.91	4	0	4
34	R:R:R255	5.196	5	1	5
35	R:R:L272	3.1125	4	0	8
36	R:R:F273	5.0275	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K6	R:R:W253	15.2911	3.48	Yes	No	0	5	1
2	R:R:W253	R:R:W254	16.8005	8.43	No	Yes	0	1	4
3	R:R:S241	R:R:W254	21.2154	4.94	No	Yes	0	5	4
4	R:R:R255	R:R:S241	22.4929	3.95	Yes	No	1	5	5
5	R:R:R255	R:R:Y238	27.6936	4.12	Yes	Yes	1	5	7
6	R:R:I93	R:R:Y94	49.7569	4.84	No	Yes	0	8	8
7	R:R:I93	R:R:L58	46.1956	2.85	No	Yes	0	8	7
8	R:R:F89	R:R:L58	13.2222	15.83	Yes	Yes	3	7	7
9	R:R:F89	R:R:K65	12.3516	7.44	Yes	No	0	7	7
10	R:R:K65	R:R:Y14	10.978	9.55	No	No	0	7	8
11	R:R:N239	R:R:Y238	37.5353	5.81	No	Yes	1	8	7
12	R:R:F188	R:R:N239	100	18.12	Yes	No	0	8	8
13	R:R:F188	R:R:F235	84.6015	3.22	Yes	Yes	0	8	9
14	R:R:F235	R:R:S96	86.1504	5.28	Yes	No	2	9	9
15	R:R:L51	R:R:S96	60.2205	3	Yes	No	2	9	9
16	R:R:F273	R:R:L51	54.528	3.65	Yes	Yes	0	9	9
17	R:R:F273	R:R:L48	52.035	8.53	Yes	Yes	0	9	8
18	R:R:F32	R:R:L48	31.1362	10.96	Yes	Yes	0	7	8
19	R:R:A28	R:R:F32	33.4313	2.77	No	Yes	0	8	7
20	R:R:A28	R:R:Y274	30.9271	4	No	No	0	8	7
21	R:R:A24	R:R:Y274	25.8847	2.67	No	No	0	7	7
22	R:R:A24	R:R:G21	23.3465	1.95	No	No	0	7	8
23	R:R:G21	R:R:L59	18.2363	1.71	No	No	0	8	6
24	R:R:L22	R:R:L59	15.6642	4.15	Yes	No	0	6	6
25	R:R:D55	R:R:S96	25.6586	4.42	Yes	No	2	9	9
26	R:R:D55	R:R:N25	26.303	6.73	Yes	Yes	0	9	9
27	R:R:N25	R:R:T52	22.0746	2.92	Yes	No	0	9	8
28	R:R:F32	R:R:T52	16.9813	5.19	Yes	No	0	7	8
29	R:R:L48	R:R:V44	35.9582	2.98	Yes	No	0	8	7
30	R:R:E106	R:R:V44	34.4093	2.85	No	No	0	8	7
31	R:R:E106	R:R:Y117	32.9791	5.61	No	No	0	8	5
32	R:R:R121	R:R:Y117	30.0283	6.17	No	No	0	7	5
33	R:R:P43	R:R:R121	27.0379	5.76	No	No	0	7	7
34	R:R:G126	R:R:P43	17.0888	2.03	No	No	0	8	7
35	R:R:G126	R:R:I46	13.7535	5.29	No	No	0	8	7
36	R:R:L51	R:R:L99	27.7388	2.77	Yes	Yes	0	9	8
37	R:R:F188	R:R:M192	37.1848	3.73	Yes	No	0	8	6
38	R:R:I196	R:R:M192	18.6603	2.92	No	No	0	4	6
39	R:R:I196	R:R:L228	18.5472	2.85	No	No	0	4	8
40	R:R:L228	R:R:Y199	36.2578	4.69	No	Yes	0	8	8
41	R:R:R107	R:R:Y199	27.7332	9.26	Yes	Yes	5	9	8
42	R:R:I103	R:R:R107	12.6682	7.52	No	Yes	0	9	9
43	R:R:L232	R:R:M192	18.5811	4.24	No	No	0	5	6
44	R:R:L228	R:R:L232	18.4681	2.77	No	No	0	8	5
45	R:R:F273	R:R:R107	17.5579	4.28	Yes	Yes	0	9	9
46	R:R:I103	R:R:L48	11.385	4.28	No	Yes	0	9	8
47	R:R:C95	R:R:L99	20.7575	3.17	Yes	Yes	0	7	8
48	R:R:L58	R:R:S92	26.987	6.01	Yes	No	0	7	8
49	R:R:L57	R:R:S92	25.5512	4.5	No	No	0	7	8
50	R:R:L57	R:R:L61	24.104	5.54	No	No	0	7	7
51	R:R:F64	R:R:L61	22.6456	4.87	No	No	0	6	7
52	R:R:F64	R:R:W75	18.3889	4.01	No	Yes	0	6	9
53	R:R:C95	R:R:W134	16.433	11.75	Yes	No	0	7	9
54	R:R:F138	R:R:W134	14.9689	6.01	No	No	0	3	9
55	R:R:F138	R:R:F87	10.4918	6.43	No	Yes	0	3	6
56	R:R:L187	R:R:Y94	11.5941	14.07	Yes	Yes	1	6	8
57	R:R:H242	R:R:Y238	15.5455	7.62	Yes	Yes	1	6	7
58	R:R:F231	R:R:F235	13.7422	5.36	Yes	Yes	2	9	9
59	R:R:F235	R:R:N265	12.2046	12.08	Yes	No	0	9	9
60	R:R:F231	R:R:T195	15.2911	5.19	Yes	No	0	9	7
61	R:R:S104	R:R:T195	14.9802	6.4	No	No	0	9	7
62	R:R:C198	R:R:S104	19.2764	1.72	No	No	0	8	9
63	R:R:C198	R:R:Y108	12.4647	8.06	No	Yes	0	8	8
64	R:R:A224	R:R:Y199	45.7603	2.67	No	Yes	0	7	8
65	R:R:A224	R:R:F202	17.0774	2.77	No	No	0	7	8
66	R:R:H140	R:R:L187	11.4189	5.14	No	Yes	0	4	6
67	R:R:V147	R:R:V176	10.5201	1.6	Yes	Yes	0	4	4
68	R:R:Q172	R:R:V176	10.6105	1.43	No	Yes	0	1	4
69	R:R:H242	R:R:R180	44.0192	7.9	Yes	No	0	6	5
70	R:R:L177	R:R:R180	17.6032	7.29	Yes	No	0	2	5
71	R:R:F188	R:R:F189	22.9226	5.36	Yes	Yes	0	8	4
72	R:R:C184	R:R:H242	17.3262	5.9	No	Yes	1	6	6
73	R:R:C184	R:R:F189	17.3205	2.79	No	Yes	1	6	4
74	R:R:A224	R:R:V203	27.281	1.7	No	No	0	7	5
75	R:R:V203	R:R:V221	24.8672	3.21	No	No	0	5	4
76	R:R:L207	R:R:V221	19.9774	2.98	No	No	0	4	4
77	R:R:L207	R:R:R217	17.5184	2.43	No	No	0	4	6
78	R:R:R217	R:R:V212	15.0537	9.15	No	No	0	6	3
79	R:R:N239	R:R:Y94	62.0011	5.81	No	Yes	1	8	8
80	R:R:H242	R:R:Y94	20.2713	3.27	Yes	Yes	1	6	8
81	R:R:P191	R:R:T97	12.1877	3.5	Yes	No	0	9	8
82	R:R:R180	R:R:V176	23.8044	3.92	No	Yes	0	5	4
83	R:R:S104	R:R:Y199	14.6297	15.26	No	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8J23_nogp

PDB Summary
PDB	8J23_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	241
Number of Links	266
Number of Hubs	36
Number of Links mediated by Hubs	128
Number of Communities	6
Number of Nodes involved in Communities	33
Number of Links involved in Communities	41

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	40523
Length Of Smallest Path	3
Average Path Length	13.2458
Length of Longest Path	30
Minimum Path Strength	1.37
Average Path Strength	5.37339
Maximum Path Strength	14.225
Minimum Path Correlation	0.7
Average Path Correlation	0.916688
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	44.9857
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.3924
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of response to biotic stimulus • immune response-regulating cell surface receptor signaling pathway • regulation of cellular process • response to stimulus • pattern recognition receptor signaling pathway • response to biotic stimulus • cell communication • immune response-activating signaling pathway • positive regulation of immune response • regulation of immune system process • signal transduction • positive regulation of immune system process • innate immune response-activating signaling pathway • regulation of biological process • immune response • response to other organism • immune response-activating cell surface receptor signaling pathway • regulation of innate immune response • response to external stimulus • regulation of response to stimulus • defense response to other organism • positive regulation of defense response • activation of innate immune response • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of response to external stimulus • signaling • positive regulation of biological process • innate immune response activating cell surface receptor signaling pathway • positive regulation of response to stimulus • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of response to stress • response to stress • innate immune response • response to external biotic stimulus • cell surface pattern recognition receptor signaling pathway • positive regulation of innate immune response • cell surface receptor signaling pathway • defense response • biological regulation • defense response to symbiont • immune system process • cellular process • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • regulation of cell communication • hormone transport • protein localization • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • cellular localization • regulation of protein localization • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • macromolecule localization • insulin secretion • multicellular organismal process • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of biosynthetic process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of interleukin-8 production • regulation of chemokine production • chemokine production • positive regulation of chemokine production • cell chemotaxis • leukocyte chemotaxis involved in inflammatory response • chemotaxis • leukocyte migration involved in inflammatory response • leukocyte migration • cellular response to chemical stimulus • taxis • response to chemical • cell migration • inflammatory response • cell motility • leukocyte chemotaxis • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • mucosal immune response • organ or tissue specific immune response • lipid storage • nutrient storage • positive regulation of acute inflammatory response • positive regulation of inflammatory response • regulation of acute inflammatory response to non-antigenic stimulus • acute inflammatory response • acute inflammatory response to non-antigenic stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response to non-antigenic stimulus • regulation of acute inflammatory response • response to lipid • response to fatty acid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to fatty acid • cellular response to lipid • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • regulation of immune effector process • positive regulation of immune effector process • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune effector process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to nitrogen compound • cell division • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • response to ketone • response to prostaglandin • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>8J23_nogp_Chain_R D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R V R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N F R W Y L P K I V C A L T G F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q T C Y E N F T D E Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L T Q P H V G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G F Y Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	Cholesterol	Gi1/β1/γ2	3.34	2024-12-11	10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	Cholesterol		3.34	2024-12-11	10.1016/j.celrep.2024.115024
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	10.1126/sciadv.adj2384
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	10.1038/s41422-023-00914-z
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	10.1038/s41422-023-00914-z

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