psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D4	R:R:K6	5.53	No	Yes	0	4	5
2	R:R:D4	R:R:S7	5.89	No	No	0	4	3
3	R:R:S8	R:R:W5	3.71	No	No	0	5	7
4	R:R:K6	R:R:W253	3.48	Yes	No	0	5	1
5	R:R:K6	R:R:S256	3.06	Yes	No	4	5	4
6	R:R:I257	R:R:K6	4.36	No	Yes	4	5	5
7	R:R:N72	R:R:S7	8.94	No	No	0	3	3
8	R:R:L9	R:R:S8	4.5	No	No	0	6	5
9	R:R:I10	R:R:V260	4.61	No	No	0	5	5
10	R:R:I16	R:R:M12	2.92	No	No	0	5	5
11	R:R:K65	R:R:Y14	9.55	No	No	0	7	8
12	R:R:I66	R:R:Y14	3.63	No	No	0	7	8
13	R:R:V260	R:R:Y14	6.31	No	No	0	5	8
14	R:R:I15	R:R:L19	2.85	No	No	0	6	4
15	R:R:I16	R:R:I17	2.94	No	Yes	0	5	7
16	R:R:I17	R:R:L62	2.85	Yes	Yes	0	7	8
17	R:R:I17	R:R:L264	2.85	Yes	No	0	7	5
18	R:R:I17	R:R:S267	7.74	Yes	No	0	7	8
19	R:R:F18	R:R:L22	3.65	No	Yes	0	7	6
20	R:R:L22	R:R:L26	5.54	Yes	No	0	6	4
21	R:R:L22	R:R:L59	4.15	Yes	No	0	6	6
22	R:R:N25	R:R:T52	2.92	Yes	No	0	9	8
23	R:R:D55	R:R:N25	6.73	Yes	Yes	0	9	9
24	R:R:L56	R:R:N25	4.12	No	Yes	0	7	9
25	R:R:N25	R:R:P270	8.15	Yes	No	0	9	9
26	R:R:A28	R:R:F32	2.77	No	Yes	0	8	7
27	R:R:A28	R:R:Y274	4	No	No	0	8	7
28	R:R:L29	R:R:T52	2.95	No	No	0	7	8
29	R:R:L29	R:R:L53	4.15	No	No	0	7	6
30	R:R:F32	R:R:L48	10.96	Yes	Yes	0	7	8
31	R:R:F32	R:R:T52	5.19	Yes	No	0	7	8
32	R:R:Q38	R:R:R35	7.01	No	No	0	5	5
33	R:R:H45	R:R:R35	21.44	No	No	0	7	5
34	R:R:L49	R:R:V36	2.98	No	No	0	6	5
35	R:R:P39	R:R:Q38	3.16	No	No	0	3	5
36	R:R:P123	R:R:P41	3.9	No	No	0	2	6
37	R:R:A42	R:R:H45	2.93	No	No	0	7	7
38	R:R:P43	R:R:R121	5.76	No	No	0	7	7
39	R:R:L48	R:R:V44	2.98	Yes	No	0	8	7
40	R:R:E106	R:R:V44	2.85	No	No	0	8	7
41	R:R:G126	R:R:I46	5.29	No	No	0	8	7
42	R:R:L47	R:R:L99	2.77	No	Yes	0	7	8
43	R:R:I103	R:R:L48	4.28	No	Yes	0	9	8
44	R:R:F273	R:R:L48	8.53	Yes	Yes	0	9	8
45	R:R:L99	R:R:S50	6.01	Yes	No	0	8	9
46	R:R:A130	R:R:S50	3.42	No	No	0	7	9
47	R:R:D55	R:R:L51	5.43	Yes	Yes	2	9	9
48	R:R:L51	R:R:S96	3	Yes	No	2	9	9
49	R:R:L51	R:R:L99	2.77	Yes	Yes	0	9	8
50	R:R:F273	R:R:L51	3.65	Yes	Yes	0	9	9
51	R:R:A54	R:R:C95	3.61	No	Yes	0	8	7
52	R:R:D55	R:R:S96	4.42	Yes	No	2	9	9
53	R:R:A266	R:R:D55	4.63	No	Yes	0	8	9
54	R:R:L56	R:R:L60	5.54	No	No	0	7	4
55	R:R:L57	R:R:L61	5.54	No	No	0	7	7
56	R:R:L57	R:R:S92	4.5	No	No	0	7	8
57	R:R:L58	R:R:L62	2.77	Yes	Yes	3	7	8
58	R:R:F89	R:R:L58	15.83	Yes	Yes	3	7	7
59	R:R:L58	R:R:S92	6.01	Yes	No	0	7	8
60	R:R:I93	R:R:L58	2.85	No	Yes	0	8	7
61	R:R:L58	R:R:S263	3	Yes	No	3	7	6
62	R:R:F64	R:R:L61	4.87	No	No	0	6	7
63	R:R:F89	R:R:L62	3.65	Yes	Yes	3	7	8
64	R:R:F64	R:R:W75	4.01	No	Yes	0	6	9
65	R:R:F64	R:R:T85	7.78	No	No	0	6	5
66	R:R:F89	R:R:K65	7.44	Yes	No	0	7	7
67	R:R:I67	R:R:W75	8.22	No	Yes	0	4	9
68	R:R:E68	R:R:F73	5.83	No	No	0	5	4
69	R:R:E68	R:R:W75	13.08	No	Yes	0	5	9
70	R:R:C164	R:R:E68	6.08	No	No	0	9	5
71	R:R:F73	R:R:T163	7.78	No	No	0	4	4
72	R:R:L77	R:R:W75	7.97	No	Yes	0	7	9
73	R:R:L77	R:R:P78	4.93	No	No	0	7	8
74	R:R:L77	R:R:V81	4.47	No	No	0	7	6
75	R:R:F138	R:R:F87	6.43	No	Yes	0	3	6
76	R:R:C141	R:R:F87	6.98	No	Yes	0	7	6
77	R:R:F87	R:R:I145	6.28	Yes	No	0	6	4
78	R:R:G88	R:R:S91	3.71	No	No	0	5	5
79	R:R:F89	R:R:S263	3.96	Yes	No	3	7	6
80	R:R:Y165	R:R:Y90	4.96	No	No	1	4	5
81	R:R:Y238	R:R:Y90	11.91	Yes	No	1	7	5
82	R:R:R255	R:R:Y90	4.12	Yes	No	1	5	5
83	R:R:F138	R:R:S91	6.61	No	No	0	3	5
84	R:R:I93	R:R:Y94	4.84	No	Yes	0	8	8
85	R:R:I93	R:R:S262	6.19	No	No	0	8	8
86	R:R:L183	R:R:Y94	10.55	No	Yes	1	5	8
87	R:R:L187	R:R:Y94	14.07	Yes	Yes	1	6	8
88	R:R:Y238	R:R:Y94	5.96	Yes	Yes	1	7	8
89	R:R:N239	R:R:Y94	5.81	No	Yes	1	8	8
90	R:R:H242	R:R:Y94	3.27	Yes	Yes	1	6	8
91	R:R:C95	R:R:L99	3.17	Yes	Yes	0	7	8
92	R:R:C95	R:R:W134	11.75	Yes	No	0	7	9
93	R:R:C95	R:R:S137	5.16	Yes	No	0	7	7
94	R:R:F235	R:R:S96	5.28	Yes	No	2	9	9
95	R:R:P191	R:R:T97	3.5	Yes	No	0	9	8
96	R:R:F231	R:R:T97	6.49	Yes	No	2	9	8
97	R:R:F235	R:R:T97	7.78	Yes	No	2	9	8
98	R:R:L187	R:R:W98	3.42	Yes	No	0	6	5
99	R:R:P191	R:R:W98	14.86	Yes	No	0	9	5
100	R:R:A133	R:R:L99	3.15	No	Yes	0	7	8
101	R:R:F231	R:R:L100	4.87	Yes	No	0	9	8
102	R:R:D269	R:R:L100	6.79	No	No	0	9	8
103	R:R:I103	R:R:R107	7.52	No	Yes	0	9	9
104	R:R:S104	R:R:T195	6.4	No	No	0	9	7
105	R:R:S104	R:R:Y199	15.26	No	Yes	0	9	8
106	R:R:I105	R:R:L109	2.85	No	No	0	6	6
107	R:R:C198	R:R:I105	3.27	No	No	0	8	6
108	R:R:E106	R:R:Y117	5.61	No	No	0	8	5
109	R:R:R107	R:R:Y199	9.26	Yes	Yes	5	9	8
110	R:R:R107	R:R:T227	3.88	Yes	No	5	9	7
111	R:R:F273	R:R:R107	4.28	Yes	Yes	0	9	9
112	R:R:A112	R:R:Y108	5.34	No	Yes	6	7	8
113	R:R:F113	R:R:Y108	3.09	Yes	Yes	6	6	8
114	R:R:C198	R:R:Y108	8.06	No	Yes	0	8	8
115	R:R:R201	R:R:Y108	17.49	No	Yes	0	4	8
116	R:R:G110	R:R:Y117	5.79	No	No	0	8	5
117	R:R:F202	R:R:V111	5.24	No	No	0	8	8
118	R:R:I205	R:R:V111	3.07	No	No	0	5	8
119	R:R:A112	R:R:F113	5.55	No	Yes	6	7	6
120	R:R:F113	R:R:Q116	4.68	Yes	No	0	6	5
121	R:R:R121	R:R:Y117	6.17	No	No	0	7	5
122	R:R:R122	R:R:Y125	10.29	No	No	0	6	4
123	R:R:I128	R:R:L124	5.71	No	No	0	1	3
124	R:R:F138	R:R:W134	6.01	No	No	0	3	9
125	R:R:H140	R:R:M136	3.94	No	No	0	4	4
126	R:R:H140	R:R:L187	5.14	No	Yes	0	4	6
127	R:R:Q148	R:R:V144	5.73	No	No	0	5	5
128	R:R:V144	R:R:V179	3.21	No	No	0	5	4
129	R:R:L183	R:R:V144	2.98	No	No	0	5	5
130	R:R:F168	R:R:Q148	3.51	No	No	0	4	5
131	R:R:E166	R:R:T163	8.47	No	No	0	5	4
132	R:R:F168	R:R:Y165	5.16	No	No	0	4	4
133	R:R:R255	R:R:Y165	5.14	Yes	No	1	5	4
134	R:R:F168	R:R:V176	5.24	No	Yes	0	4	4
135	R:R:E171	R:R:T169	12.7	No	No	0	3	4
136	R:R:Q172	R:R:T169	2.83	No	No	0	1	4
137	R:R:R180	R:R:V176	3.92	No	Yes	0	5	4
138	R:R:L177	R:R:R180	7.29	Yes	No	0	2	5
139	R:R:H242	R:R:R180	7.9	Yes	No	0	6	5
140	R:R:L181	R:R:L185	4.15	No	No	0	5	5
141	R:R:F246	R:R:L181	6.09	No	No	0	4	5
142	R:R:E182	R:R:V186	4.28	No	No	0	4	4
143	R:R:L183	R:R:L187	5.54	No	Yes	1	5	6
144	R:R:C184	R:R:F189	2.79	No	Yes	1	6	4
145	R:R:C184	R:R:H242	5.9	No	Yes	1	6	6
146	R:R:C184	R:R:L243	3.17	No	No	1	6	5
147	R:R:F189	R:R:L185	3.65	Yes	No	0	4	5
148	R:R:I190	R:R:V186	4.61	No	No	0	5	4
149	R:R:F188	R:R:F189	5.36	Yes	Yes	0	8	4
150	R:R:F188	R:R:M192	3.73	Yes	No	0	8	6
151	R:R:F188	R:R:F235	3.22	Yes	Yes	0	8	9
152	R:R:F188	R:R:N239	18.12	Yes	No	0	8	8
153	R:R:F189	R:R:L243	7.31	Yes	No	1	4	5
154	R:R:I190	R:R:P191	3.39	No	Yes	0	5	9
155	R:R:I196	R:R:M192	2.92	No	No	0	4	6
156	R:R:L232	R:R:M192	4.24	No	No	0	5	6
157	R:R:F231	R:R:T195	5.19	Yes	No	0	9	7
158	R:R:I196	R:R:L228	2.85	No	No	0	4	8
159	R:R:F197	R:R:R201	9.62	No	No	0	5	4
160	R:R:T227	R:R:Y199	8.74	No	Yes	5	7	8
161	R:R:L228	R:R:Y199	4.69	No	Yes	0	8	8
162	R:R:A224	R:R:F202	2.77	No	No	0	7	8
163	R:R:V203	R:R:V221	3.21	No	No	0	5	4
164	R:R:L207	R:R:V221	2.98	No	No	0	4	4
165	R:R:P210	R:R:Q209	7.9	No	No	0	3	5
166	R:R:Q209	R:R:V212	2.87	No	No	0	5	3
167	R:R:H211	R:R:P210	4.58	No	No	0	3	3
168	R:R:R217	R:R:V212	9.15	No	No	0	6	3
169	R:R:G213	R:R:R216	7.51	No	No	0	4	5
170	R:R:Q215	R:R:R218	5.84	No	No	0	4	5
171	R:R:F275	R:R:R219	7.48	No	No	0	7	7
172	R:R:G222	R:R:V221	3.68	No	No	0	5	4
173	R:R:L272	R:R:V226	4.47	Yes	No	0	8	5
174	R:R:L272	R:R:T227	2.95	Yes	No	0	8	7
175	R:R:L228	R:R:L232	2.77	No	No	0	8	5
176	R:R:C234	R:R:N230	3.15	No	No	0	8	7
177	R:R:L268	R:R:N230	6.87	No	No	0	7	7
178	R:R:F231	R:R:F235	5.36	Yes	Yes	2	9	9
179	R:R:C234	R:R:N265	7.87	No	No	0	8	9
180	R:R:F235	R:R:N265	12.08	Yes	No	0	9	9
181	R:R:G236	R:R:P237	4.06	No	No	0	5	9
182	R:R:F261	R:R:P237	5.78	No	No	0	7	9
183	R:R:N239	R:R:Y238	5.81	No	Yes	1	8	7
184	R:R:H242	R:R:Y238	7.62	Yes	Yes	1	6	7
185	R:R:R255	R:R:Y238	4.12	Yes	Yes	1	5	7
186	R:R:P252	R:R:S241	7.13	No	No	1	1	5
187	R:R:S241	R:R:W254	4.94	No	Yes	0	5	4
188	R:R:R255	R:R:S241	3.95	Yes	No	1	5	5
189	R:R:V244	R:R:W254	3.68	No	Yes	0	5	4
190	R:R:P252	R:R:S251	3.56	No	No	0	1	4
191	R:R:P252	R:R:R255	8.65	No	Yes	1	1	5
192	R:R:W253	R:R:W254	8.43	No	Yes	0	1	4
193	R:R:I257	R:R:S256	3.1	No	No	4	5	4
194	R:R:S262	R:R:V259	3.23	No	No	0	8	5
195	R:R:L264	R:R:L268	5.54	No	No	0	5	7
196	R:R:D269	R:R:N265	14.81	No	No	0	9	9
197	R:R:F273	R:R:L272	3.65	Yes	Yes	0	9	8
198	R:R:A24	R:R:Y274	2.67	No	No	0	7	7
199	R:R:A224	R:R:Y199	2.67	No	Yes	0	7	8
200	R:R:R74	R:R:S71	2.64	No	No	0	4	4
201	R:R:E166	R:R:N167	2.63	No	No	0	5	4
202	R:R:R30	R:R:V33	2.62	No	Yes	0	4	4
203	R:R:R216	R:R:V212	2.62	No	No	0	5	3
204	R:R:F87	R:R:T142	2.59	Yes	No	0	6	4
205	R:R:A258	R:R:W254	2.59	No	Yes	0	7	4
206	R:R:F261	R:R:I257	2.51	No	No	0	7	5
207	R:R:F202	R:R:M206	2.49	No	No	0	8	8
208	R:R:K118	R:R:R121	2.48	No	No	0	4	7
209	R:R:F18	R:R:L19	2.44	No	No	0	7	4
210	R:R:F32	R:R:L49	2.44	Yes	No	0	7	6
211	R:R:F275	R:R:L223	2.44	No	No	0	7	7
212	R:R:L207	R:R:R217	2.43	No	No	0	4	6
213	R:R:I205	R:R:W204	2.35	No	No	0	5	3
214	R:R:Q215	R:R:R219	2.34	No	No	0	4	7
215	R:R:L271	R:R:Y274	2.34	No	No	0	7	7
216	R:R:G126	R:R:P43	2.03	No	No	0	8	7
217	R:R:A24	R:R:G21	1.95	No	No	0	7	8
218	R:R:A129	R:R:G126	1.95	No	No	0	5	8
219	R:R:A42	R:R:P43	1.87	No	No	0	7	7
220	R:R:A101	R:R:P191	1.87	No	Yes	0	8	9
221	R:R:W200	R:R:W204	1.87	No	No	0	3	3
222	R:R:G34	R:R:V33	1.84	No	Yes	0	4	4
223	R:R:G236	R:R:V240	1.84	No	No	0	5	6
224	R:R:G21	R:R:T20	1.82	No	No	0	8	5
225	R:R:G86	R:R:T85	1.82	No	No	0	6	5
226	R:R:G139	R:R:T142	1.82	No	No	0	4	4
227	R:R:G102	R:R:I105	1.76	No	No	0	6	6
228	R:R:C198	R:R:S104	1.72	No	No	0	8	9
229	R:R:G21	R:R:L59	1.71	No	No	0	8	6
230	R:R:A70	R:R:S71	1.71	No	No	0	4	4
231	R:R:G245	R:R:L177	1.71	No	Yes	0	5	2
232	R:R:C234	R:R:V233	1.71	No	No	0	8	5
233	R:R:A13	R:R:V260	1.7	No	No	0	4	5
234	R:R:A101	R:R:V194	1.7	No	No	0	8	6
235	R:R:A224	R:R:V203	1.7	No	No	0	7	5
236	R:R:I46	R:R:P123	1.69	No	No	0	7	2
237	R:R:I80	R:R:P78	1.69	No	No	0	4	8
238	R:R:L22	R:R:P23	1.64	Yes	No	0	6	4
239	R:R:L62	R:R:P63	1.64	Yes	No	0	8	9
240	R:R:L177	R:R:P178	1.64	Yes	No	0	2	2
241	R:R:A69	R:R:I10	1.62	No	No	0	5	5
242	R:R:A83	R:R:I145	1.62	No	No	0	7	4
243	R:R:A83	R:R:K79	1.61	No	No	0	7	2
244	R:R:A220	R:R:M206	1.61	No	No	0	7	8
245	R:R:V147	R:R:V175	1.6	Yes	No	0	4	3
246	R:R:V147	R:R:V176	1.6	Yes	Yes	0	4	4
247	R:R:V147	R:R:V179	1.6	Yes	No	0	4	4
248	R:R:A69	R:R:L11	1.58	No	No	0	5	5
249	R:R:P39	R:R:Q40	1.58	No	No	0	3	5
250	R:R:P41	R:R:Q40	1.58	No	No	0	6	5
251	R:R:I46	R:R:V127	1.54	No	No	0	7	4
252	R:R:I128	R:R:V132	1.54	No	No	0	1	4
253	R:R:I146	R:R:V147	1.54	No	Yes	0	4	4
254	R:R:M136	R:R:V132	1.52	No	No	0	4	4
255	R:R:G34	R:R:R37	1.5	No	No	0	4	5
256	R:R:L29	R:R:V33	1.49	No	Yes	0	7	4
257	R:R:L49	R:R:V33	1.49	No	Yes	0	6	4
258	R:R:L131	R:R:V127	1.49	No	No	0	4	4
259	R:R:F113	R:R:P114	1.44	Yes	No	0	6	8
260	R:R:P123	R:R:R122	1.44	No	No	0	2	6
261	R:R:Q172	R:R:V176	1.43	No	Yes	0	1	4
262	R:R:L173	R:R:L177	1.38	No	Yes	0	1	2
263	R:R:L223	R:R:L272	1.38	No	Yes	0	7	8
264	R:R:D170	R:R:L173	1.36	No	No	0	1	1
265	R:R:Q248	R:R:Y247	1.13	No	No	0	3	4
266	R:R:F246	R:R:R249	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K6	4.1075	4	4	5
2	R:R:I17	4.095	4	0	7
3	R:R:L22	3.745	4	0	6
4	R:R:N25	5.48	4	0	9
5	R:R:F32	5.34	4	0	7
6	R:R:V33	1.86	4	0	4
7	R:R:L48	6.6875	4	0	8
8	R:R:L51	3.7125	4	2	9
9	R:R:D55	5.3025	4	2	9
10	R:R:L58	6.092	5	3	7
11	R:R:L62	2.7275	4	3	8
12	R:R:W75	8.32	4	0	9
13	R:R:F87	5.57	4	0	6
14	R:R:F89	7.72	4	3	7
15	R:R:Y94	7.41667	6	1	8
16	R:R:C95	5.9225	4	0	7
17	R:R:L99	3.574	5	0	8
18	R:R:R107	6.235	4	5	9
19	R:R:Y108	8.495	4	6	8
20	R:R:F113	3.69	4	6	6
21	R:R:V147	1.585	4	0	4
22	R:R:V176	3.0475	4	0	4
23	R:R:L177	3.005	4	0	2
24	R:R:L187	7.0425	4	1	6
25	R:R:F188	7.6075	4	0	8
26	R:R:F189	4.7775	4	1	4
27	R:R:P191	5.905	4	0	9
28	R:R:Y199	8.124	5	5	8
29	R:R:F231	5.4775	4	2	9
30	R:R:F235	6.744	5	2	9
31	R:R:Y238	7.084	5	1	7
32	R:R:H242	6.1725	4	1	6
33	R:R:W254	4.91	4	0	4
34	R:R:R255	5.196	5	1	5
35	R:R:L272	3.1125	4	0	8
36	R:R:F273	5.0275	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K6	R:R:W253	15.2911	3.48	Yes	No	0	5	1
2	R:R:W253	R:R:W254	16.8005	8.43	No	Yes	0	1	4
3	R:R:S241	R:R:W254	21.2154	4.94	No	Yes	0	5	4
4	R:R:R255	R:R:S241	22.4929	3.95	Yes	No	1	5	5
5	R:R:R255	R:R:Y238	27.6936	4.12	Yes	Yes	1	5	7
6	R:R:I93	R:R:Y94	49.7569	4.84	No	Yes	0	8	8
7	R:R:I93	R:R:L58	46.1956	2.85	No	Yes	0	8	7
8	R:R:F89	R:R:L58	13.2222	15.83	Yes	Yes	3	7	7
9	R:R:F89	R:R:K65	12.3516	7.44	Yes	No	0	7	7
10	R:R:K65	R:R:Y14	10.978	9.55	No	No	0	7	8
11	R:R:N239	R:R:Y238	37.5353	5.81	No	Yes	1	8	7
12	R:R:F188	R:R:N239	100	18.12	Yes	No	0	8	8
13	R:R:F188	R:R:F235	84.6015	3.22	Yes	Yes	0	8	9
14	R:R:F235	R:R:S96	86.1504	5.28	Yes	No	2	9	9
15	R:R:L51	R:R:S96	60.2205	3	Yes	No	2	9	9
16	R:R:F273	R:R:L51	54.528	3.65	Yes	Yes	0	9	9
17	R:R:F273	R:R:L48	52.035	8.53	Yes	Yes	0	9	8
18	R:R:F32	R:R:L48	31.1362	10.96	Yes	Yes	0	7	8
19	R:R:A28	R:R:F32	33.4313	2.77	No	Yes	0	8	7
20	R:R:A28	R:R:Y274	30.9271	4	No	No	0	8	7
21	R:R:A24	R:R:Y274	25.8847	2.67	No	No	0	7	7
22	R:R:A24	R:R:G21	23.3465	1.95	No	No	0	7	8
23	R:R:G21	R:R:L59	18.2363	1.71	No	No	0	8	6
24	R:R:L22	R:R:L59	15.6642	4.15	Yes	No	0	6	6
25	R:R:D55	R:R:S96	25.6586	4.42	Yes	No	2	9	9
26	R:R:D55	R:R:N25	26.303	6.73	Yes	Yes	0	9	9
27	R:R:N25	R:R:T52	22.0746	2.92	Yes	No	0	9	8
28	R:R:F32	R:R:T52	16.9813	5.19	Yes	No	0	7	8
29	R:R:L48	R:R:V44	35.9582	2.98	Yes	No	0	8	7
30	R:R:E106	R:R:V44	34.4093	2.85	No	No	0	8	7
31	R:R:E106	R:R:Y117	32.9791	5.61	No	No	0	8	5
32	R:R:R121	R:R:Y117	30.0283	6.17	No	No	0	7	5
33	R:R:P43	R:R:R121	27.0379	5.76	No	No	0	7	7
34	R:R:G126	R:R:P43	17.0888	2.03	No	No	0	8	7
35	R:R:G126	R:R:I46	13.7535	5.29	No	No	0	8	7
36	R:R:L51	R:R:L99	27.7388	2.77	Yes	Yes	0	9	8
37	R:R:F188	R:R:M192	37.1848	3.73	Yes	No	0	8	6
38	R:R:I196	R:R:M192	18.6603	2.92	No	No	0	4	6
39	R:R:I196	R:R:L228	18.5472	2.85	No	No	0	4	8
40	R:R:L228	R:R:Y199	36.2578	4.69	No	Yes	0	8	8
41	R:R:R107	R:R:Y199	27.7332	9.26	Yes	Yes	5	9	8
42	R:R:I103	R:R:R107	12.6682	7.52	No	Yes	0	9	9
43	R:R:L232	R:R:M192	18.5811	4.24	No	No	0	5	6
44	R:R:L228	R:R:L232	18.4681	2.77	No	No	0	8	5
45	R:R:F273	R:R:R107	17.5579	4.28	Yes	Yes	0	9	9
46	R:R:I103	R:R:L48	11.385	4.28	No	Yes	0	9	8
47	R:R:C95	R:R:L99	20.7575	3.17	Yes	Yes	0	7	8
48	R:R:L58	R:R:S92	26.987	6.01	Yes	No	0	7	8
49	R:R:L57	R:R:S92	25.5512	4.5	No	No	0	7	8
50	R:R:L57	R:R:L61	24.104	5.54	No	No	0	7	7
51	R:R:F64	R:R:L61	22.6456	4.87	No	No	0	6	7
52	R:R:F64	R:R:W75	18.3889	4.01	No	Yes	0	6	9
53	R:R:C95	R:R:W134	16.433	11.75	Yes	No	0	7	9
54	R:R:F138	R:R:W134	14.9689	6.01	No	No	0	3	9
55	R:R:F138	R:R:F87	10.4918	6.43	No	Yes	0	3	6
56	R:R:L187	R:R:Y94	11.5941	14.07	Yes	Yes	1	6	8
57	R:R:H242	R:R:Y238	15.5455	7.62	Yes	Yes	1	6	7
58	R:R:F231	R:R:F235	13.7422	5.36	Yes	Yes	2	9	9
59	R:R:F235	R:R:N265	12.2046	12.08	Yes	No	0	9	9
60	R:R:F231	R:R:T195	15.2911	5.19	Yes	No	0	9	7
61	R:R:S104	R:R:T195	14.9802	6.4	No	No	0	9	7
62	R:R:C198	R:R:S104	19.2764	1.72	No	No	0	8	9
63	R:R:C198	R:R:Y108	12.4647	8.06	No	Yes	0	8	8
64	R:R:A224	R:R:Y199	45.7603	2.67	No	Yes	0	7	8
65	R:R:A224	R:R:F202	17.0774	2.77	No	No	0	7	8
66	R:R:H140	R:R:L187	11.4189	5.14	No	Yes	0	4	6
67	R:R:V147	R:R:V176	10.5201	1.6	Yes	Yes	0	4	4
68	R:R:Q172	R:R:V176	10.6105	1.43	No	Yes	0	1	4
69	R:R:H242	R:R:R180	44.0192	7.9	Yes	No	0	6	5
70	R:R:L177	R:R:R180	17.6032	7.29	Yes	No	0	2	5
71	R:R:F188	R:R:F189	22.9226	5.36	Yes	Yes	0	8	4
72	R:R:C184	R:R:H242	17.3262	5.9	No	Yes	1	6	6
73	R:R:C184	R:R:F189	17.3205	2.79	No	Yes	1	6	4
74	R:R:A224	R:R:V203	27.281	1.7	No	No	0	7	5
75	R:R:V203	R:R:V221	24.8672	3.21	No	No	0	5	4
76	R:R:L207	R:R:V221	19.9774	2.98	No	No	0	4	4
77	R:R:L207	R:R:R217	17.5184	2.43	No	No	0	4	6
78	R:R:R217	R:R:V212	15.0537	9.15	No	No	0	6	3
79	R:R:N239	R:R:Y94	62.0011	5.81	No	Yes	1	8	8
80	R:R:H242	R:R:Y94	20.2713	3.27	Yes	Yes	1	6	8
81	R:R:P191	R:R:T97	12.1877	3.5	Yes	No	0	9	8
82	R:R:R180	R:R:V176	23.8044	3.92	No	Yes	0	5	4
83	R:R:S104	R:R:Y199	14.6297	15.26	No	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8J23_nogp

PDB Summary
PDB	8J23_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	241
Number of Links	266
Number of Hubs	36
Number of Links mediated by Hubs	128
Number of Communities	6
Number of Nodes involved in Communities	33
Number of Links involved in Communities	41

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	40523
Length Of Smallest Path	3
Average Path Length	13.2458
Length of Longest Path	30
Minimum Path Strength	1.37
Average Path Strength	5.37339
Maximum Path Strength	14.225
Minimum Path Correlation	0.7
Average Path Correlation	0.916733
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	44.9857
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.3924
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>8J23_nogp_Chain_R D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R V R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N F R W Y L P K I V C A L T G F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q T C Y E N F T D E Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L T Q P H V G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G F Y Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	Gi1/β1/γ2	3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8Y6W	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	Gi1/β1/γ2	3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6W (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6Y	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	GLPG0974	-	-	3.36	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	9CLW	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CLW (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729	Gi1/β1/γ2	3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729		3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	Gi1/β1/γ2	3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8J23_nogp.zip

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