psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y90	24.34	Yes	No	2	0	5
2	L:L:?1	R:R:C141	4.54	Yes	No	0	0	7
3	L:L:?1	R:R:V144	11.73	Yes	No	0	0	5
4	L:L:?1	R:R:I145	4.09	Yes	No	0	0	4
5	L:L:?1	R:R:Q148	12.39	Yes	No	2	0	5
6	L:L:?1	R:R:Y165	15.94	Yes	Yes	2	0	4
7	L:L:?1	R:R:Q172	3.81	Yes	No	0	0	1
8	L:L:?1	R:R:V175	4.27	Yes	No	0	0	3
9	L:L:?1	R:R:V176	11.73	Yes	No	2	0	4
10	L:L:?1	R:R:V179	8.53	Yes	No	0	0	4
11	L:L:?1	R:R:R180	6.09	Yes	Yes	2	0	5
12	L:L:?1	R:R:Y238	4.2	Yes	Yes	2	0	7
13	R:R:N72	R:R:P3	4.89	No	No	0	3	8
14	R:R:D4	R:R:W5	4.47	No	No	0	4	7
15	R:R:K6	R:R:W5	5.8	No	No	0	5	7
16	R:R:L9	R:R:M12	4.24	No	No	0	6	5
17	R:R:I10	R:R:V260	4.61	No	No	0	5	5
18	R:R:K65	R:R:Y14	4.78	No	No	0	7	8
19	R:R:I66	R:R:Y14	4.84	No	No	0	7	8
20	R:R:V260	R:R:Y14	8.83	No	No	0	5	8
21	R:R:I17	R:R:S267	7.74	No	No	0	7	8
22	R:R:F18	R:R:L22	7.31	No	No	0	7	6
23	R:R:F18	R:R:L62	4.87	No	No	0	7	8
24	R:R:G21	R:R:T20	3.64	No	No	0	8	5
25	R:R:L22	R:R:P23	4.93	No	No	0	6	4
26	R:R:L22	R:R:L26	4.15	No	No	0	6	4
27	R:R:A24	R:R:P270	3.74	No	No	0	7	9
28	R:R:A24	R:R:F275	4.16	No	No	0	7	7
29	R:R:D55	R:R:N25	4.04	Yes	No	0	9	9
30	R:R:L59	R:R:N25	6.87	No	No	0	6	9
31	R:R:N25	R:R:P270	4.89	No	No	0	9	9
32	R:R:F275	R:R:L27	4.87	No	No	0	7	6
33	R:R:A28	R:R:Y274	4	No	No	0	8	7
34	R:R:L29	R:R:T52	4.42	Yes	No	0	7	8
35	R:R:L29	R:R:L53	4.15	Yes	No	0	7	6
36	R:R:A31	R:R:Y274	6.67	No	No	0	7	7
37	R:R:F32	R:R:L48	14.61	No	No	0	7	8
38	R:R:F32	R:R:T52	7.78	No	No	0	7	8
39	R:R:Q38	R:R:R35	5.84	No	No	0	5	5
40	R:R:H45	R:R:R35	18.05	No	No	0	7	5
41	R:R:P123	R:R:P41	5.84	No	No	0	2	6
42	R:R:A42	R:R:H45	4.39	No	No	0	7	7
43	R:R:A42	R:R:R121	6.91	No	No	0	7	7
44	R:R:E106	R:R:P43	4.72	Yes	Yes	4	8	7
45	R:R:P43	W:W:?1	5.38	Yes	Yes	4	7	0
46	R:R:E106	R:R:V44	5.7	Yes	No	0	8	7
47	R:R:E106	R:R:L47	3.98	Yes	No	0	8	7
48	R:R:I103	R:R:L48	5.71	No	No	1	9	8
49	R:R:F273	R:R:L48	6.09	Yes	No	1	9	8
50	R:R:L99	R:R:S50	4.5	Yes	No	0	8	9
51	R:R:D55	R:R:L51	6.79	Yes	Yes	1	9	9
52	R:R:D269	R:R:L51	10.86	Yes	Yes	1	9	9
53	R:R:F273	R:R:L51	4.87	Yes	Yes	1	9	9
54	R:R:D55	R:R:S96	4.42	Yes	No	0	9	9
55	R:R:A266	R:R:D55	4.63	No	Yes	0	8	9
56	R:R:D269	R:R:D55	7.98	Yes	Yes	1	9	9
57	R:R:F89	R:R:L58	8.53	Yes	No	0	7	7
58	R:R:L58	R:R:S92	9.01	No	No	0	7	8
59	R:R:A266	R:R:L58	6.3	No	No	0	8	7
60	R:R:F89	R:R:L62	3.65	Yes	No	0	7	8
61	R:R:F64	R:R:Y76	4.13	No	Yes	0	6	3
62	R:R:F64	R:R:T85	12.97	No	No	0	6	5
63	R:R:E68	R:R:K65	6.75	No	No	0	5	7
64	R:R:F89	R:R:K65	3.72	Yes	No	0	7	7
65	R:R:I67	R:R:Y76	7.25	No	Yes	0	4	3
66	R:R:E68	R:R:Y76	25.81	No	Yes	3	5	3
67	R:R:C164	R:R:E68	10.64	No	No	3	9	5
68	R:R:A69	R:R:F73	8.32	No	No	0	5	4
69	R:R:S71	R:R:W75	3.71	No	No	0	4	9
70	R:R:N72	R:R:W75	7.91	No	No	0	3	9
71	R:R:E166	R:R:F73	4.66	No	No	0	5	4
72	R:R:F73	R:R:S256	3.96	No	No	0	4	4
73	R:R:R74	R:R:W75	24.99	No	No	0	4	9
74	R:R:P78	R:R:Y76	19.47	No	Yes	3	8	3
75	R:R:V81	R:R:Y76	3.79	No	Yes	3	6	3
76	R:R:C82	R:R:Y76	5.38	No	Yes	3	9	3
77	R:R:T163	R:R:Y76	3.75	No	Yes	0	4	3
78	R:R:C164	R:R:Y76	5.38	No	Yes	3	9	3
79	R:R:L77	R:R:P78	4.93	No	No	0	7	8
80	R:R:P78	R:R:V81	5.3	No	No	3	8	6
81	R:R:C164	R:R:C82	7.28	No	No	3	9	9
82	R:R:A83	R:R:Y165	4	No	Yes	0	7	4
83	R:R:F87	R:R:G88	6.02	Yes	No	0	6	5
84	R:R:F138	R:R:F87	4.29	No	Yes	0	3	6
85	R:R:F87	R:R:T142	3.89	Yes	No	0	6	4
86	R:R:G88	R:R:S91	3.71	No	No	0	5	5
87	R:R:F89	R:R:S263	5.28	Yes	No	0	7	6
88	R:R:Y238	R:R:Y90	11.91	Yes	No	2	7	5
89	R:R:F138	R:R:S91	15.85	No	No	0	3	5
90	R:R:I93	R:R:S262	9.29	No	No	0	8	8
91	R:R:L183	R:R:Y94	10.55	No	Yes	0	5	8
92	R:R:L187	R:R:Y94	5.86	No	Yes	0	6	8
93	R:R:N239	R:R:Y94	5.81	No	Yes	0	8	8
94	R:R:H242	R:R:Y94	4.36	Yes	Yes	0	6	8
95	R:R:C95	R:R:S137	5.16	No	No	0	7	7
96	R:R:F188	R:R:T97	3.89	Yes	No	1	8	8
97	R:R:F231	R:R:T97	3.89	Yes	No	1	9	8
98	R:R:F235	R:R:T97	12.97	Yes	No	1	9	8
99	R:R:M136	R:R:W98	12.8	No	No	0	4	5
100	R:R:P191	R:R:W98	16.21	No	No	0	9	5
101	R:R:W98	W:W:?1	11.2	No	Yes	0	5	0
102	R:R:F231	R:R:L100	6.09	Yes	No	1	9	8
103	R:R:L100	R:R:N265	5.49	No	Yes	1	8	9
104	R:R:D269	R:R:L100	4.07	Yes	No	1	9	8
105	R:R:F273	R:R:I103	7.54	Yes	No	1	9	9
106	R:R:S104	R:R:T195	7.99	No	No	0	9	7
107	R:R:C198	R:R:S104	5.16	No	No	0	8	9
108	R:R:S104	R:R:Y199	12.72	No	Yes	0	9	8
109	R:R:E106	W:W:?1	10.14	Yes	Yes	4	8	0
110	R:R:R107	R:R:Y199	10.29	No	Yes	1	9	8
111	R:R:R107	R:R:T227	3.88	No	No	1	9	7
112	R:R:F273	R:R:R107	5.34	Yes	No	1	9	9
113	R:R:A112	R:R:Y108	6.67	No	Yes	0	7	8
114	R:R:F113	R:R:Y108	6.19	Yes	Yes	0	6	8
115	R:R:C198	R:R:Y108	6.72	No	Yes	0	8	8
116	R:R:R201	R:R:Y108	8.23	No	Yes	0	4	8
117	R:R:F113	R:R:L109	3.65	Yes	No	0	6	6
118	R:R:G110	R:R:Y117	5.79	No	No	0	8	5
119	R:R:F202	R:R:V111	6.55	No	No	0	8	8
120	R:R:F113	R:R:Q116	7.03	Yes	No	0	6	5
121	R:R:R122	R:R:Y125	15.43	No	No	0	6	4
122	R:R:I128	R:R:L124	5.71	No	No	0	1	3
123	R:R:Y125	W:W:?1	7.69	No	Yes	0	4	0
124	R:R:A129	W:W:?1	5.17	No	Yes	0	5	0
125	R:R:V132	W:W:?1	4.88	No	Yes	0	4	0
126	R:R:F138	R:R:W134	15.03	No	No	0	3	9
127	R:R:H140	R:R:M136	5.25	Yes	No	0	4	4
128	R:R:G139	R:R:T142	3.64	No	No	0	4	4
129	R:R:E182	R:R:H140	9.85	No	Yes	0	4	4
130	R:R:H140	R:R:L187	7.71	Yes	No	0	4	6
131	R:R:Q148	R:R:Y149	9.02	No	No	0	5	5
132	R:R:Q148	R:R:Y165	11.27	No	Yes	2	5	4
133	R:R:F168	R:R:Y165	6.19	No	Yes	0	4	4
134	R:R:E166	R:R:N167	3.94	No	No	0	5	4
135	R:R:F168	R:R:Q172	8.2	No	No	0	4	1
136	R:R:Q172	R:R:T169	8.5	No	No	0	1	4
137	R:R:R180	R:R:V176	7.85	Yes	No	2	5	4
138	R:R:L177	R:R:R249	6.07	Yes	No	0	2	4
139	R:R:H242	R:R:R180	19.18	Yes	Yes	0	6	5
140	R:R:R180	R:R:R255	15.99	Yes	No	0	5	5
141	R:R:L181	R:R:L185	4.15	No	No	0	5	5
142	R:R:L181	R:R:Y246	10.55	No	No	0	5	4
143	R:R:E182	R:R:L183	3.98	No	No	0	4	5
144	R:R:E182	R:R:V186	4.28	No	No	0	4	4
145	R:R:C184	R:R:N239	4.72	No	No	0	6	8
146	R:R:C184	R:R:H242	4.42	No	Yes	0	6	6
147	R:R:C184	R:R:L243	4.76	No	No	0	6	5
148	R:R:F188	R:R:F189	4.29	Yes	No	1	8	4
149	R:R:F188	R:R:M192	7.46	Yes	No	1	8	6
150	R:R:F188	R:R:N239	27.79	Yes	No	0	8	8
151	R:R:F189	R:R:M192	3.73	No	No	1	4	6
152	R:R:F231	R:R:M192	3.73	Yes	No	1	9	6
153	R:R:V194	W:W:?1	4.88	No	Yes	0	6	0
154	R:R:F231	R:R:T195	3.89	Yes	No	0	9	7
155	R:R:I196	R:R:L232	5.71	No	No	0	4	5
156	R:R:C198	R:R:F197	4.19	No	No	0	8	5
157	R:R:F197	R:R:R201	9.62	No	No	0	5	4
158	R:R:T227	R:R:Y199	8.74	No	Yes	1	7	8
159	R:R:W200	R:R:W204	13.12	No	No	0	3	3
160	R:R:F202	R:R:M206	8.71	No	No	0	8	8
161	R:R:L211	R:R:Q209	7.99	No	No	0	3	5
162	R:R:L211	R:R:V212	4.47	No	No	0	3	3
163	R:R:G213	R:R:R217	4.5	No	No	0	4	6
164	R:R:A214	R:R:R218	6.91	No	No	0	3	5
165	R:R:Q215	R:R:R216	10.51	No	No	0	4	5
166	R:R:R219	R:R:S276	6.59	No	No	0	7	7
167	R:R:L223	R:R:S276	6.01	No	No	0	7	7
168	R:R:L272	R:R:V226	4.47	No	No	0	8	5
169	R:R:L268	R:R:N230	10.98	No	No	0	7	7
170	R:R:L272	R:R:N230	5.49	No	No	0	8	7
171	R:R:F231	R:R:L232	3.65	Yes	No	0	9	5
172	R:R:F231	R:R:F235	6.43	Yes	Yes	1	9	9
173	R:R:C234	R:R:N265	6.3	No	Yes	0	8	9
174	R:R:F235	R:R:S262	3.96	Yes	No	0	9	8
175	R:R:F235	R:R:N265	10.87	Yes	Yes	1	9	9
176	R:R:G236	R:R:P237	4.06	No	No	0	5	9
177	R:R:H242	R:R:Y238	6.53	Yes	Yes	0	6	7
178	R:R:R255	R:R:Y238	8.23	No	Yes	0	5	7
179	R:R:A258	R:R:Y238	4	No	Yes	0	7	7
180	R:R:H242	R:R:S241	4.18	Yes	No	0	6	5
181	R:R:S241	R:R:W254	4.94	No	Yes	0	5	4
182	R:R:G245	R:R:V244	3.68	No	No	0	5	5
183	R:R:Q248	R:R:V244	5.73	No	No	0	3	5
184	R:R:V244	R:R:W254	4.9	No	Yes	0	5	4
185	R:R:G245	R:R:P252	4.06	No	Yes	0	5	1
186	R:R:P252	R:R:S251	3.56	Yes	No	0	1	4
187	R:R:P252	R:R:W254	4.05	Yes	Yes	0	1	4
188	R:R:P252	R:R:R255	8.65	Yes	No	0	1	5
189	R:R:W253	R:R:W254	13.12	No	Yes	0	1	4
190	R:R:L264	R:R:L268	8.3	No	No	0	5	7
191	R:R:D269	R:R:N265	13.46	Yes	Yes	1	9	9
192	R:R:D269	R:R:F273	5.97	Yes	Yes	1	9	9
193	R:R:F275	R:R:Y274	10.32	No	No	0	7	7
194	R:R:L177	R:R:Y246	3.52	Yes	No	0	2	4
195	R:R:L228	R:R:Y199	3.52	No	Yes	0	8	8
196	L:L:?1	R:R:F87	3.49	Yes	Yes	0	0	6
197	R:R:A101	W:W:?1	3.44	No	Yes	0	8	0
198	R:R:A130	R:R:S50	3.42	No	No	0	7	9
199	R:R:I190	R:R:P191	3.39	No	No	0	5	9
200	R:R:E106	R:R:Y117	3.37	Yes	No	0	8	5
201	R:R:S120	W:W:?1	3.28	No	Yes	0	4	0
202	R:R:V203	R:R:V221	3.21	No	No	0	5	4
203	R:R:C95	R:R:L99	3.17	No	Yes	0	7	8
204	R:R:P39	R:R:Q38	3.16	No	No	0	3	5
205	R:R:P210	R:R:Q209	3.16	No	No	0	3	5
206	R:R:A133	R:R:L99	3.15	No	Yes	0	7	8
207	R:R:C234	R:R:N230	3.15	No	No	0	8	7
208	R:R:I10	R:R:S256	3.1	No	No	0	5	4
209	R:R:I17	R:R:S263	3.1	No	No	0	7	6
210	R:R:I257	R:R:S256	3.1	No	No	0	5	4
211	R:R:I46	R:R:V127	3.07	No	No	0	7	4
212	R:R:I205	R:R:V111	3.07	No	No	0	5	8
213	R:R:K79	R:R:V80	3.04	No	No	0	2	4
214	R:R:I146	R:R:T142	3.04	No	No	0	4	4
215	R:R:G34	R:R:R37	3	No	No	0	4	5
216	R:R:L57	R:R:S92	3	No	No	0	7	8
217	R:R:N72	R:R:S7	2.98	No	No	0	3	3
218	R:R:L119	R:R:V115	2.98	No	No	0	4	6
219	R:R:L207	R:R:V221	2.98	No	No	0	4	4
220	R:R:L229	R:R:V233	2.98	No	No	0	4	5
221	R:R:L243	R:R:V240	2.98	No	No	0	5	6
222	R:R:I15	R:R:I16	2.94	No	No	0	6	5
223	R:R:F261	R:R:P237	2.89	No	No	0	7	9
224	R:R:P123	R:R:R122	2.88	No	No	0	2	6
225	R:R:I146	R:R:L150	2.85	No	No	0	4	2
226	R:R:L29	R:R:L56	2.77	Yes	No	0	7	7
227	R:R:L49	R:R:L53	2.77	No	No	0	6	6
228	R:R:L51	R:R:L99	2.77	Yes	Yes	0	9	8
229	R:R:L173	R:R:L177	2.77	No	Yes	0	1	2
230	R:R:L181	R:R:L243	2.77	No	No	0	5	5
231	R:R:A224	R:R:F202	2.77	No	No	0	7	8
232	R:R:A224	R:R:Y199	2.67	No	Yes	0	7	8
233	R:R:F89	R:R:V259	2.62	Yes	No	0	7	5
234	R:R:S86	R:R:Y90	2.54	No	No	0	6	5
235	R:R:F64	R:R:L61	2.44	No	No	0	6	7
236	R:R:L124	R:R:R122	2.43	No	No	0	3	6
237	R:R:N167	R:R:R74	2.41	No	No	0	4	4
238	R:R:D174	R:R:R249	2.38	No	No	0	1	4
239	R:R:I105	W:W:?1	2.34	No	Yes	0	6	0
240	R:R:L131	R:R:W134	2.28	No	No	0	4	9
241	R:R:G126	R:R:P43	2.03	No	Yes	0	8	7
242	R:R:A101	R:R:G102	1.95	No	No	0	8	6
243	R:R:A42	R:R:P43	1.87	No	Yes	0	7	7
244	R:R:G21	R:R:S267	1.86	No	No	0	8	8
245	R:R:G34	R:R:V33	1.84	No	No	0	4	4
246	R:R:G213	R:R:V212	1.84	No	No	0	4	3
247	R:R:G222	R:R:V221	1.84	No	No	0	5	4
248	R:R:G222	R:R:V225	1.84	No	No	0	5	5
249	R:R:A54	R:R:C95	1.81	No	No	0	8	7
250	R:R:G126	R:R:I46	1.76	No	No	0	8	7
251	R:R:A224	R:R:V203	1.7	No	No	0	7	5
252	R:R:I36	R:R:P41	1.69	No	No	0	5	6
253	R:R:I66	R:R:P63	1.69	No	No	0	7	9
254	R:R:L177	R:R:P178	1.64	Yes	No	0	2	2
255	R:R:G213	R:R:Q215	1.64	No	No	0	4	4
256	R:R:S7	R:R:S8	1.63	No	No	0	3	5
257	R:R:S277	R:R:S278	1.63	No	No	0	8	4
258	R:R:A220	R:R:M206	1.61	No	No	0	7	8
259	R:R:A69	R:R:L11	1.58	No	No	0	5	5
260	R:R:A70	R:R:L11	1.58	No	No	0	4	5
261	R:R:P41	R:R:Q40	1.58	No	No	0	6	5
262	R:R:I205	R:R:S208	1.55	No	No	0	5	4
263	R:R:F188	R:R:G236	1.51	Yes	No	0	8	5
264	R:R:L29	R:R:V33	1.49	Yes	No	0	7	4
265	R:R:L49	R:R:V33	1.49	No	No	0	6	4
266	R:R:D4	R:R:S7	1.47	No	No	0	4	3
267	R:R:N171	R:R:T169	1.46	No	No	0	3	4
268	R:R:F113	R:R:P114	1.44	Yes	No	0	6	8
269	R:R:Q116	R:R:V115	1.43	No	No	0	5	6
270	R:R:K6	R:R:L9	1.41	No	No	0	5	6
271	R:R:D170	R:R:K250	1.38	No	No	0	1	2
272	R:R:A214	R:R:R217	1.38	No	No	0	3	6
273	R:R:M206	R:R:Q209	1.36	No	No	0	8	5
274	R:R:H140	R:R:I143	1.33	Yes	No	0	4	7
275	R:R:H247	R:R:Q248	1.24	No	No	0	4	3
276	R:R:V135	R:R:W134	1.23	No	No	0	4	9
277	L:L:?1	R:R:V147	1.07	Yes	No	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.30143	14	2	0
2	R:R:L29	3.2075	4	0	7
3	R:R:P43	3.5	4	4	7
4	R:R:L51	6.3225	4	1	9
5	R:R:D55	5.572	5	1	9
6	R:R:Y76	9.37	8	3	3
7	R:R:F87	4.4225	4	0	6
8	R:R:F89	4.76	5	0	7
9	R:R:Y94	6.645	4	0	8
10	R:R:L99	3.3975	4	0	8
11	R:R:E106	5.582	5	4	8
12	R:R:Y108	6.9525	4	0	8
13	R:R:F113	4.5775	4	0	6
14	R:R:H140	6.035	4	0	4
15	R:R:Y165	9.35	4	2	4
16	R:R:L177	3.5	4	0	2
17	R:R:R180	12.2775	4	2	5
18	R:R:F188	8.988	5	1	8
19	R:R:Y199	7.588	5	1	8
20	R:R:F231	4.61333	6	1	9
21	R:R:F235	8.5575	4	1	9
22	R:R:Y238	6.974	5	2	7
23	R:R:H242	7.734	5	0	6
24	R:R:P252	5.08	4	0	1
25	R:R:W254	6.7525	4	0	4
26	R:R:N265	9.03	4	1	9
27	R:R:D269	8.468	5	1	9
28	R:R:F273	5.962	5	1	9
29	W:W:?1	5.84	10	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R180	28.3047	6.09	Yes	Yes	2	0	5
2	R:R:H242	R:R:R180	33.8166	19.18	Yes	Yes	0	6	5
3	R:R:H242	R:R:Y94	42.1619	4.36	Yes	Yes	0	6	8
4	R:R:N239	R:R:Y94	57.696	5.81	No	Yes	0	8	8
5	R:R:F188	R:R:N239	100	27.79	Yes	No	0	8	8
6	R:R:F188	R:R:T97	63.8489	3.89	Yes	No	1	8	8
7	R:R:F231	R:R:T97	36.5281	3.89	Yes	No	1	9	8
8	R:R:F231	R:R:L100	51.6077	6.09	Yes	No	1	9	8
9	R:R:D269	R:R:L100	50.9667	4.07	Yes	No	1	9	8
10	R:R:D269	R:R:D55	61.4053	7.98	Yes	Yes	1	9	9
11	R:R:A266	R:R:D55	56.1282	4.63	No	Yes	0	8	9
12	R:R:A266	R:R:L58	55.1609	6.3	No	No	0	8	7
13	R:R:F89	R:R:L58	52.2437	8.53	Yes	No	0	7	7
14	R:R:F89	R:R:K65	40.3377	3.72	Yes	No	0	7	7
15	R:R:K65	R:R:Y14	26.2076	4.78	No	No	0	7	8
16	R:R:V260	R:R:Y14	23.2853	8.83	No	No	0	5	8
17	R:R:I10	R:R:V260	22.2342	4.61	No	No	0	5	5
18	R:R:I10	R:R:S256	21.1793	3.1	No	No	0	5	4
19	R:R:F73	R:R:S256	19.2815	3.96	No	No	0	4	4
20	R:R:E166	R:R:F73	15.0251	4.66	No	No	0	5	4
21	R:R:E166	R:R:N167	14.158	3.94	No	No	0	5	4
22	R:R:N167	R:R:R74	13.0841	2.41	No	No	0	4	4
23	R:R:R74	R:R:W75	12.0076	24.99	No	No	0	4	9
24	L:L:?1	R:R:Y238	28.2704	4.2	Yes	Yes	2	0	7
25	R:R:H242	R:R:Y238	35.7943	6.53	Yes	Yes	0	6	7
26	R:R:C184	R:R:H242	39.199	4.42	No	Yes	0	6	6
27	R:R:C184	R:R:N239	43.2764	4.72	No	No	0	6	8
28	R:R:F188	R:R:M192	36.6588	7.46	Yes	No	1	8	6
29	R:R:F231	R:R:M192	36.7604	3.73	Yes	No	1	9	6
30	R:R:F235	R:R:T97	27.3335	12.97	Yes	No	1	9	8
31	R:R:F235	R:R:N265	27.0276	10.87	Yes	Yes	1	9	9
32	R:R:D269	R:R:N265	25.9397	13.46	Yes	Yes	1	9	9
33	R:R:D269	R:R:F273	16.4887	5.97	Yes	Yes	1	9	9
34	R:R:F273	R:R:L48	12.0114	6.09	Yes	No	1	9	8
35	R:R:F32	R:R:L48	10.954	14.61	No	No	0	7	8
36	R:R:L187	R:R:Y94	22.5097	5.86	No	Yes	0	6	8
37	R:R:H140	R:R:L187	21.9511	7.71	Yes	No	0	4	6
38	R:R:H140	R:R:M136	20.9483	5.25	Yes	No	0	4	4
39	R:R:M136	R:R:W98	20.3783	12.8	No	No	0	4	5
40	R:R:W98	W:W:?1	18.6404	11.2	No	Yes	0	5	0
41	R:R:E68	R:R:K65	14.158	6.75	No	No	0	5	7
42	R:R:E68	R:R:Y76	10.9032	25.81	No	Yes	3	5	3
43	L:L:?1	R:R:F87	24.9127	3.49	Yes	Yes	0	0	6
44	R:R:F138	R:R:F87	10.5198	4.29	No	Yes	0	3	6
45	R:R:F231	R:R:T195	23.5963	3.89	Yes	No	0	9	7
46	R:R:S104	R:R:T195	22.9616	7.99	No	No	0	9	7
47	R:R:C198	R:R:S104	10.6912	5.16	No	No	0	8	9
48	R:R:S104	R:R:Y199	17.2809	12.72	No	Yes	0	9	8
49	R:R:A224	R:R:Y199	17.1196	2.67	No	Yes	0	7	8
50	R:R:A224	R:R:F202	12.6055	2.77	No	No	0	7	8
51	R:R:H242	R:R:S241	10.629	4.18	Yes	No	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y90	24.34	2	Yes	No	0	5	0	1
L:L:?1	R:R:C141	4.54	2	Yes	No	0	7	0	1
L:L:?1	R:R:V144	11.73	2	Yes	No	0	5	0	1
L:L:?1	R:R:I145	4.09	2	Yes	No	0	4	0	1
L:L:?1	R:R:Q148	12.39	2	Yes	No	0	5	0	1
L:L:?1	R:R:Y165	15.94	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Q172	3.81	2	Yes	No	0	1	0	1
L:L:?1	R:R:V175	4.27	2	Yes	No	0	3	0	1
L:L:?1	R:R:V176	11.73	2	Yes	No	0	4	0	1
L:L:?1	R:R:V179	8.53	2	Yes	No	0	4	0	1
L:L:?1	R:R:R180	6.09	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y238	4.2	2	Yes	Yes	0	7	0	1
R:R:A83	R:R:Y165	4	0	No	Yes	7	4	2	1
R:R:F87	R:R:G88	6.02	0	Yes	No	6	5	1	2
R:R:F138	R:R:F87	4.29	0	No	Yes	3	6	2	1
R:R:F87	R:R:T142	3.89	0	Yes	No	6	4	1	2
R:R:Y238	R:R:Y90	11.91	2	Yes	No	7	5	1	1
R:R:Q148	R:R:Y149	9.02	2	No	No	5	5	1	2
R:R:Q148	R:R:Y165	11.27	2	No	Yes	5	4	1	1
R:R:F168	R:R:Y165	6.19	0	No	Yes	4	4	2	1
R:R:F168	R:R:Q172	8.2	0	No	No	4	1	2	1
R:R:Q172	R:R:T169	8.5	0	No	No	1	4	1	2
R:R:R180	R:R:V176	7.85	2	Yes	No	5	4	1	1
R:R:H242	R:R:R180	19.18	0	Yes	Yes	6	5	2	1
R:R:R180	R:R:R255	15.99	2	Yes	No	5	5	1	2
R:R:H242	R:R:Y238	6.53	0	Yes	Yes	6	7	2	1
R:R:R255	R:R:Y238	8.23	0	No	Yes	5	7	2	1
R:R:A258	R:R:Y238	4	0	No	Yes	7	7	2	1
L:L:?1	R:R:F87	3.49	2	Yes	Yes	0	6	0	1
R:R:S86	R:R:Y90	2.54	0	No	No	6	5	2	1
L:L:?1	R:R:V147	1.07	2	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E106	R:R:P43	4.72	4	Yes	Yes	8	7	1	1
R:R:P43	W:W:?1	5.38	4	Yes	Yes	7	0	1	0
R:R:E106	R:R:V44	5.7	4	Yes	No	8	7	1	2
R:R:E106	R:R:L47	3.98	4	Yes	No	8	7	1	2
R:R:M136	R:R:W98	12.8	0	No	No	4	5	2	1
R:R:P191	R:R:W98	16.21	0	No	No	9	5	2	1
R:R:W98	W:W:?1	11.2	0	No	Yes	5	0	1	0
R:R:E106	W:W:?1	10.14	4	Yes	Yes	8	0	1	0
R:R:R122	R:R:Y125	15.43	0	No	No	6	4	2	1
R:R:Y125	W:W:?1	7.69	0	No	Yes	4	0	1	0
R:R:A129	W:W:?1	5.17	0	No	Yes	5	0	1	0
R:R:V132	W:W:?1	4.88	0	No	Yes	4	0	1	0
R:R:V194	W:W:?1	4.88	0	No	Yes	6	0	1	0
R:R:A101	W:W:?1	3.44	0	No	Yes	8	0	1	0
R:R:E106	R:R:Y117	3.37	4	Yes	No	8	5	1	2
R:R:S120	W:W:?1	3.28	0	No	Yes	4	0	1	0
R:R:I105	W:W:?1	2.34	0	No	Yes	6	0	1	0
R:R:G126	R:R:P43	2.03	0	No	Yes	8	7	2	1
R:R:A101	R:R:G102	1.95	0	No	No	8	6	1	2
R:R:A42	R:R:P43	1.87	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9CM7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.56
Number of Linked Nodes	258
Number of Links	277
Number of Hubs	29
Number of Links mediated by Hubs	126
Number of Communities	4
Number of Nodes involved in Communities	33
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	52
Number Of Links MetaPath	51
Number of Shortest Paths	102603
Length Of Smallest Path	3
Average Path Length	16.7623
Length of Longest Path	39
Minimum Path Strength	1.485
Average Path Strength	7.49845
Maximum Path Strength	22.64
Minimum Path Correlation	0.7
Average Path Correlation	0.918793
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	38.4185
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.8349
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9UJ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	9UJ
Name	(2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid
Synonyms	TUG-1375
Identifier
Formula	C22 H19 Cl N2 O4 S
Molecular Weight	442.915
SMILES
PubChem	138319694
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	17


Code	A1A
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	A1A
Name	6-AMINO HEXANOIC ACID
Synonyms
Identifier
Formula	C33 H40 N4 O6
Molecular Weight	588.694
SMILES
PubChem	5327090
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	4
Total Bonds	86
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>9CM7_nogp_Chain_R P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N F R W Y L P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T C Y E N F T D N Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q P L V G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F S S S V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187	Gi1/β1/γ2	3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187		3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729	Gi1/β1/γ2	3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729		3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	8Y6W	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	Gi1/β1/γ2	3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6W (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	9CLW	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CLW (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	-	Gi1/β1/γ2	3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	-		3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8Y6Y	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	GLPG0974	-	-	3.36	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9CM7_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.