psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y90	30.9	Yes	Yes	2	0	5
2	L:L:?1	R:R:C141	3.64	Yes	No	0	0	7
3	L:L:?1	R:R:I143	6.54	Yes	No	0	0	7
4	L:L:?1	R:R:V144	3.41	Yes	Yes	2	0	5
5	L:L:?1	R:R:Y165	13.44	Yes	Yes	2	0	4
6	L:L:?1	R:R:R180	4.18	Yes	No	2	0	5
7	L:L:?1	R:R:L183	4.76	Yes	No	0	0	5
8	L:L:?1	R:R:Y238	6.72	Yes	Yes	2	0	7
9	L:L:?1	R:R:H242	4.42	Yes	Yes	2	0	6
10	L:L:?1	R:R:R255	11.14	Yes	Yes	2	0	5
11	R:R:D4	R:R:W5	21.22	No	No	0	4	7
12	R:R:F73	R:R:K6	7.44	No	Yes	0	4	5
13	R:R:K6	R:R:W253	4.64	Yes	No	0	5	1
14	R:R:K6	R:R:S256	6.12	Yes	No	0	5	4
15	R:R:I257	R:R:K6	7.27	No	Yes	0	5	5
16	R:R:N72	R:R:S7	4.47	No	No	0	3	3
17	R:R:I10	R:R:Y14	6.04	No	Yes	0	5	8
18	R:R:K65	R:R:Y14	5.97	No	Yes	0	7	8
19	R:R:I66	R:R:Y14	7.25	No	Yes	0	7	8
20	R:R:V260	R:R:Y14	5.05	No	Yes	0	5	8
21	R:R:I17	R:R:S263	3.1	Yes	No	0	7	6
22	R:R:I17	R:R:L264	4.28	Yes	No	0	7	5
23	R:R:I17	R:R:S267	4.64	Yes	No	0	7	8
24	R:R:F18	R:R:L22	3.65	No	No	0	7	6
25	R:R:G21	R:R:L59	5.13	No	No	0	8	6
26	R:R:L22	R:R:L59	8.3	No	No	0	6	6
27	R:R:A24	R:R:P270	3.74	No	No	0	7	9
28	R:R:N25	R:R:T52	5.85	Yes	No	0	9	8
29	R:R:D55	R:R:N25	6.73	No	Yes	0	9	9
30	R:R:N25	R:R:P270	13.03	Yes	No	0	9	9
31	R:R:F275	R:R:L27	3.65	No	No	0	7	6
32	R:R:L29	R:R:T52	4.42	No	No	0	7	8
33	R:R:A31	R:R:Y274	4	No	No	0	7	7
34	R:R:F32	R:R:L48	10.96	No	No	0	7	8
35	R:R:F32	R:R:T52	7.78	No	No	0	7	8
36	R:R:Q38	R:R:R35	9.35	No	No	0	5	5
37	R:R:H45	R:R:R35	22.57	No	No	0	7	5
38	R:R:P39	R:R:Q38	3.16	No	No	0	3	5
39	R:R:P123	R:R:P41	3.9	No	No	0	2	6
40	R:R:A42	R:R:H45	4.39	No	No	0	7	7
41	R:R:P43	W:W:?1	4.91	No	Yes	0	7	0
42	R:R:E106	R:R:V44	8.56	No	No	0	8	7
43	R:R:I46	R:R:V127	3.07	No	No	0	7	4
44	R:R:I103	R:R:L47	4.28	No	No	1	9	7
45	R:R:E106	R:R:L47	5.3	No	No	1	8	7
46	R:R:L47	W:W:?1	4.14	No	Yes	1	7	0
47	R:R:F273	R:R:L48	4.87	Yes	No	0	9	8
48	R:R:L99	R:R:S50	6.01	Yes	No	0	8	9
49	R:R:S50	R:R:W134	7.41	No	Yes	0	9	9
50	R:R:L51	R:R:S96	4.5	Yes	No	0	9	9
51	R:R:L51	R:R:L99	5.54	Yes	Yes	0	9	8
52	R:R:L100	R:R:L51	4.15	Yes	Yes	1	8	9
53	R:R:D269	R:R:L51	6.79	Yes	Yes	1	9	9
54	R:R:A266	R:R:D55	4.63	No	No	0	8	9
55	R:R:D269	R:R:D55	7.98	Yes	No	0	9	9
56	R:R:L56	R:R:L60	5.54	No	No	0	7	4
57	R:R:F89	R:R:L58	8.53	Yes	No	0	7	7
58	R:R:L58	R:R:S92	7.51	No	No	0	7	8
59	R:R:A266	R:R:L58	6.3	No	No	0	8	7
60	R:R:F64	R:R:T85	6.49	No	No	0	6	5
61	R:R:F89	R:R:K65	3.72	Yes	No	0	7	7
62	R:R:E68	R:R:W75	4.36	No	Yes	0	5	9
63	R:R:R74	R:R:S71	3.95	No	No	4	4	4
64	R:R:S71	R:R:Y76	6.36	No	No	4	4	3
65	R:R:R74	R:R:W75	7	No	Yes	0	4	9
66	R:R:R74	R:R:Y76	10.29	No	No	4	4	3
67	R:R:T163	R:R:W75	8.49	No	Yes	0	4	9
68	R:R:C164	R:R:W75	7.84	No	Yes	0	9	9
69	R:R:E166	R:R:W75	5.45	No	Yes	0	5	9
70	R:R:N167	R:R:W75	3.39	No	Yes	0	4	9
71	R:R:L77	R:R:P78	3.28	No	No	5	7	8
72	R:R:L77	R:R:V81	4.47	No	No	5	7	6
73	R:R:C82	R:R:L77	6.35	No	No	0	9	7
74	R:R:P78	R:R:V81	5.3	No	No	5	8	6
75	R:R:V80	R:R:Y149	6.31	No	No	0	4	5
76	R:R:C164	R:R:C82	5.46	No	No	0	9	9
77	R:R:A83	R:R:Q148	3.03	No	Yes	0	7	5
78	R:R:S86	R:R:Y90	5.09	No	Yes	2	6	5
79	R:R:S86	R:R:V144	3.23	No	Yes	2	6	5
80	R:R:S86	R:R:Y165	6.36	No	Yes	2	6	4
81	R:R:F87	R:R:G88	4.52	No	No	0	6	5
82	R:R:F87	R:R:V144	5.24	No	Yes	0	6	5
83	R:R:F89	R:R:I93	3.77	Yes	No	0	7	8
84	R:R:F89	R:R:V259	3.93	Yes	No	0	7	5
85	R:R:Y165	R:R:Y90	7.94	Yes	Yes	2	4	5
86	R:R:Y238	R:R:Y90	9.93	Yes	Yes	2	7	5
87	R:R:R255	R:R:Y90	8.23	Yes	Yes	2	5	5
88	R:R:S137	R:R:S91	4.89	No	No	6	7	5
89	R:R:F138	R:R:S91	7.93	Yes	No	6	3	5
90	R:R:L183	R:R:Y94	11.72	No	Yes	0	5	8
91	R:R:L187	R:R:Y94	8.21	No	Yes	0	6	8
92	R:R:Y238	R:R:Y94	3.97	Yes	Yes	0	7	8
93	R:R:N239	R:R:Y94	4.65	No	Yes	0	8	8
94	R:R:C95	R:R:L99	3.17	No	Yes	0	7	8
95	R:R:C95	R:R:W134	7.84	No	Yes	0	7	9
96	R:R:C95	R:R:S137	3.44	No	No	0	7	7
97	R:R:F231	R:R:T97	6.49	Yes	No	1	9	8
98	R:R:F235	R:R:T97	14.27	No	No	1	9	8
99	R:R:V132	R:R:W98	3.68	No	Yes	0	4	5
100	R:R:L187	R:R:W98	6.83	No	Yes	0	6	5
101	R:R:P191	R:R:W98	14.86	No	Yes	0	9	5
102	R:R:W98	W:W:?2	7.95	Yes	Yes	0	5	0
103	R:R:A133	R:R:L99	3.15	No	Yes	0	7	8
104	R:R:F231	R:R:L100	4.87	Yes	Yes	1	9	8
105	R:R:L100	R:R:N265	4.12	Yes	Yes	1	8	9
106	R:R:D269	R:R:L100	5.43	Yes	Yes	1	9	8
107	R:R:I103	R:R:R107	5.01	No	No	1	9	9
108	R:R:F273	R:R:I103	3.77	Yes	No	1	9	9
109	R:R:S104	R:R:T195	7.99	No	No	0	9	7
110	R:R:C198	R:R:S104	5.16	Yes	No	0	8	9
111	R:R:S104	R:R:Y199	5.09	No	Yes	0	9	8
112	R:R:C198	R:R:I105	4.91	Yes	No	0	8	6
113	R:R:E106	W:W:?1	6.61	No	Yes	1	8	0
114	R:R:R107	R:R:Y199	4.12	No	Yes	0	9	8
115	R:R:F273	R:R:R107	7.48	Yes	No	1	9	9
116	R:R:L109	R:R:Y108	4.69	No	Yes	0	6	8
117	R:R:A112	R:R:Y108	5.34	No	Yes	0	7	8
118	R:R:C198	R:R:Y108	4.03	Yes	Yes	0	8	8
119	R:R:R201	R:R:Y108	5.14	Yes	Yes	0	4	8
120	R:R:L109	W:W:?1	16.56	No	Yes	0	6	0
121	R:R:G110	R:R:Y117	7.24	No	No	0	8	5
122	R:R:F202	R:R:V111	7.87	No	No	0	8	8
123	R:R:A112	R:R:F113	5.55	No	No	0	7	6
124	R:R:F113	W:W:?1	7.29	No	Yes	0	6	0
125	R:R:Q116	W:W:?1	18.58	No	Yes	0	5	0
126	R:R:R121	R:R:Y117	14.4	No	No	0	7	5
127	R:R:Y117	W:W:?1	7.01	No	Yes	0	5	0
128	R:R:L119	R:R:S120	3	No	No	0	4	4
129	R:R:S120	W:W:?1	5.99	No	Yes	0	4	0
130	R:R:P123	R:R:R122	15.85	No	No	0	2	6
131	R:R:L124	R:R:R122	6.07	No	No	0	3	6
132	R:R:R122	R:R:Y125	6.17	No	No	0	6	4
133	R:R:Y125	W:W:?1	8.18	No	Yes	1	4	0
134	R:R:Y125	W:W:?2	15.2	No	Yes	1	4	0
135	R:R:A129	W:W:?1	4.71	No	Yes	1	5	0
136	R:R:A129	W:W:?2	4.71	No	Yes	1	5	0
137	R:R:F138	R:R:W134	3.01	Yes	Yes	0	3	9
138	R:R:F138	R:R:S137	3.96	Yes	No	6	3	7
139	R:R:E182	R:R:H140	4.92	No	No	0	4	4
140	R:R:H140	R:R:L183	7.71	No	No	0	4	5
141	R:R:H140	R:R:L187	5.14	No	No	0	4	6
142	R:R:I143	R:R:V179	7.68	No	No	0	7	4
143	R:R:V144	R:R:Y165	6.31	Yes	Yes	2	5	4
144	R:R:I146	R:R:V147	3.07	No	Yes	0	4	4
145	R:R:Q148	R:R:V147	5.73	Yes	Yes	0	5	4
146	R:R:Q172	R:R:V147	5.73	Yes	Yes	3	1	4
147	R:R:V147	R:R:V176	3.21	Yes	No	3	4	4
148	R:R:Q148	R:R:Y165	7.89	Yes	Yes	0	5	4
149	R:R:L150	R:R:N171	5.49	No	No	3	2	3
150	R:R:L150	R:R:Q172	3.99	No	Yes	3	2	1
151	R:R:F168	R:R:Y165	5.16	No	Yes	0	4	4
152	R:R:R255	R:R:Y165	7.2	Yes	Yes	2	5	4
153	R:R:F168	R:R:Q172	7.03	No	Yes	0	4	1
154	R:R:F168	R:R:V176	7.87	No	No	0	4	4
155	R:R:N171	R:R:T169	5.85	No	No	3	3	4
156	R:R:Q172	R:R:T169	8.5	Yes	No	3	1	4
157	R:R:N171	R:R:Q172	9.24	No	Yes	3	3	1
158	R:R:H242	R:R:R180	16.93	Yes	No	2	6	5
159	R:R:R180	R:R:R255	5.33	No	Yes	2	5	5
160	R:R:L181	R:R:Y246	8.21	No	No	0	5	4
161	R:R:C184	R:R:N239	4.72	No	No	0	6	8
162	R:R:F189	R:R:L185	6.09	No	No	0	4	5
163	R:R:F188	R:R:F189	4.29	Yes	No	0	8	4
164	R:R:F188	R:R:M192	7.46	Yes	No	0	8	6
165	R:R:F188	R:R:N239	30.21	Yes	No	0	8	8
166	R:R:I190	R:R:P191	3.39	No	No	0	5	9
167	R:R:I196	R:R:M192	4.37	No	No	0	4	6
168	R:R:F231	R:R:T195	9.08	Yes	No	0	9	7
169	R:R:I196	R:R:L232	5.71	No	No	0	4	5
170	R:R:F197	R:R:R201	6.41	No	Yes	0	5	4
171	R:R:T227	R:R:Y199	8.74	No	Yes	0	7	8
172	R:R:L228	R:R:Y199	8.21	No	Yes	0	8	8
173	R:R:R201	R:R:W200	4	Yes	No	0	4	3
174	R:R:I205	R:R:R201	6.26	No	Yes	0	5	4
175	R:R:F202	R:R:M206	6.22	No	No	0	8	8
176	R:R:A220	R:R:M206	3.22	No	No	0	7	8
177	R:R:M206	R:R:V221	3.04	No	No	0	8	4
178	R:R:P210	R:R:Q209	7.9	No	No	0	3	5
179	R:R:Q209	R:R:V212	10.03	No	Yes	0	5	3
180	R:R:R217	R:R:V212	9.15	No	Yes	0	6	3
181	R:R:Q215	R:R:R219	12.85	No	No	0	4	7
182	R:R:L223	R:R:S276	6.01	No	No	0	7	7
183	R:R:C234	R:R:N230	4.72	No	No	1	8	7
184	R:R:N230	R:R:N265	13.62	No	Yes	1	7	9
185	R:R:L268	R:R:N230	4.12	No	No	0	7	7
186	R:R:F231	R:R:F235	4.29	Yes	No	1	9	9
187	R:R:C234	R:R:N265	7.87	No	Yes	1	8	9
188	R:R:F235	R:R:N265	9.67	No	Yes	1	9	9
189	R:R:G236	R:R:P237	4.06	No	No	0	5	9
190	R:R:H242	R:R:Y238	6.53	Yes	Yes	2	6	7
191	R:R:S262	R:R:Y238	3.82	No	Yes	0	8	7
192	R:R:S241	R:R:W254	4.94	No	Yes	0	5	4
193	R:R:G245	R:R:V244	3.68	No	Yes	0	5	5
194	R:R:V244	R:R:W254	7.36	Yes	Yes	0	5	4
195	R:R:G245	R:R:P252	4.06	No	No	0	5	1
196	R:R:K250	R:R:Q248	4.07	No	No	0	2	3
197	R:R:P252	R:R:S251	3.56	No	No	0	1	4
198	R:R:P252	R:R:W254	6.76	No	Yes	0	1	4
199	R:R:D269	R:R:N265	12.12	Yes	Yes	1	9	9
200	R:R:L268	R:R:L271	4.15	No	No	0	7	7
201	R:R:D269	R:R:F273	4.78	Yes	Yes	1	9	9
202	R:R:F275	R:R:L271	3.65	No	No	0	7	7
203	R:R:F273	R:R:L272	4.87	Yes	No	0	9	8
204	R:R:S278	R:R:V279	3.23	No	No	0	4	5
205	W:W:?1	W:W:?2	49.55	Yes	Yes	1	0	0
206	R:R:L207	R:R:V221	2.98	No	No	0	4	4
207	R:R:L19	R:R:T20	2.95	No	No	0	4	5
208	R:R:L61	R:R:T85	2.95	No	No	0	7	5
209	R:R:I16	R:R:I17	2.94	No	Yes	0	5	7
210	R:R:F18	R:R:P63	2.89	No	No	0	7	9
211	R:R:Q248	R:R:V244	2.87	No	Yes	0	3	5
212	R:R:E182	R:R:V186	2.85	No	No	0	4	4
213	R:R:W253	R:R:W254	2.81	No	Yes	0	1	4
214	R:R:H242	R:R:S241	2.79	Yes	No	0	6	5
215	R:R:D4	R:R:K6	2.77	No	Yes	0	4	5
216	R:R:A28	R:R:F32	2.77	No	No	0	8	7
217	R:R:L49	R:R:L53	2.77	No	No	0	6	6
218	R:R:L57	R:R:L61	2.77	No	No	0	7	7
219	R:R:A69	R:R:F73	2.77	No	No	0	5	4
220	R:R:L181	R:R:L243	2.77	No	No	0	5	5
221	R:R:A224	R:R:F202	2.77	No	No	0	7	8
222	R:R:L264	R:R:L268	2.77	No	No	0	5	7
223	R:R:L59	R:R:N25	2.75	No	Yes	0	6	9
224	R:R:K79	R:R:Q148	2.71	No	Yes	0	2	5
225	R:R:A28	R:R:Y274	2.67	No	No	0	8	7
226	R:R:A258	R:R:Y238	2.67	No	Yes	0	7	7
227	R:R:H45	R:R:I36	2.65	No	No	0	7	5
228	R:R:R219	R:R:S277	2.64	No	No	0	7	8
229	R:R:R216	R:R:V212	2.62	No	Yes	0	5	3
230	R:R:F89	R:R:L62	2.44	Yes	No	0	7	8
231	R:R:I145	R:R:Y149	2.42	No	No	0	4	5
232	R:R:Q40	R:R:R121	2.34	No	No	0	5	7
233	R:R:L177	R:R:Y246	2.34	Yes	No	0	2	4
234	R:R:M136	R:R:W98	2.33	No	Yes	0	4	5
235	R:R:E166	R:R:Y165	2.24	No	Yes	0	5	4
236	R:R:G21	R:R:P23	2.03	No	No	0	8	4
237	R:R:G126	R:R:P43	2.03	No	No	0	8	7
238	R:R:A101	R:R:G102	1.95	No	No	0	8	6
239	R:R:A42	R:R:P43	1.87	No	No	0	7	7
240	R:R:A101	R:R:P191	1.87	No	No	0	8	9
241	R:R:G34	R:R:V33	1.84	No	No	0	4	4
242	R:R:G213	R:R:V212	1.84	No	Yes	0	4	3
243	R:R:G222	R:R:V225	1.84	No	No	0	5	5
244	R:R:G21	R:R:T20	1.82	No	No	0	8	5
245	R:R:G126	R:R:I46	1.76	No	No	0	8	7
246	R:R:A130	R:R:S50	1.71	No	No	0	7	9
247	R:R:A54	R:R:S92	1.71	No	No	0	8	8
248	R:R:A54	R:R:S96	1.71	No	No	0	8	9
249	R:R:G88	R:R:L61	1.71	No	No	0	5	7
250	R:R:C198	R:R:V194	1.71	Yes	No	0	8	6
251	R:R:A13	R:R:V260	1.7	No	No	0	4	5
252	R:R:A224	R:R:V203	1.7	No	No	0	7	5
253	R:R:G34	R:R:Q38	1.64	No	No	0	4	5
254	R:R:L177	R:R:P178	1.64	Yes	No	0	2	2
255	R:R:A193	R:R:M192	1.61	No	No	0	3	6
256	R:R:V147	R:R:V175	1.6	Yes	No	3	4	3
257	R:R:V175	R:R:V176	1.6	No	No	3	3	4
258	R:R:V221	R:R:V225	1.6	No	No	0	4	5
259	R:R:V240	R:R:V244	1.6	No	Yes	0	6	5
260	R:R:C184	R:R:L243	1.59	No	No	0	6	5
261	R:R:A13	R:R:L9	1.58	No	No	0	4	6
262	R:R:A70	R:R:L11	1.58	No	No	0	4	5
263	R:R:I205	R:R:V111	1.54	No	No	0	5	8
264	R:R:F138	R:R:G139	1.51	Yes	No	0	3	4
265	R:R:F188	R:R:G236	1.51	Yes	No	0	8	5
266	R:R:L9	R:R:S8	1.5	No	No	0	6	5
267	R:R:L49	R:R:V33	1.49	No	No	0	6	4
268	R:R:L119	R:R:V115	1.49	No	No	0	4	6
269	R:R:L272	R:R:V226	1.49	No	No	0	8	5
270	R:R:L84	R:R:T85	1.47	No	No	0	5	5
271	R:R:F113	R:R:P114	1.44	No	No	0	6	8
272	R:R:F261	R:R:P237	1.44	No	No	0	7	9
273	R:R:L22	R:R:L26	1.38	No	No	0	6	4
274	R:R:L29	R:R:L56	1.38	No	No	0	7	7
275	R:R:L173	R:R:L177	1.38	No	Yes	0	1	2
276	R:R:I205	R:R:Q209	1.37	No	No	0	5	5
277	R:R:D170	R:R:D174	1.33	No	No	0	1	1
278	R:R:F275	R:R:V279	1.31	No	No	0	7	5
279	R:R:K118	R:R:R121	1.24	No	No	0	4	7
280	R:R:H247	R:R:Q248	1.24	No	No	0	4	3
281	R:R:L177	R:R:R249	1.21	Yes	No	0	2	4
282	R:R:L223	R:R:R219	1.21	No	No	0	7	7
283	R:R:L131	R:R:W134	1.14	No	Yes	0	4	9
284	R:R:R30	R:R:R37	1.07	No	No	0	4	5
285	R:R:R201	R:R:W204	1	Yes	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.915	10	2	0
2	R:R:K6	5.648	5	0	5
3	R:R:Y14	6.0775	4	0	8
4	R:R:I17	3.74	4	0	7
5	R:R:N25	7.09	4	0	9
6	R:R:L51	5.245	4	1	9
7	R:R:W75	6.08833	6	0	9
8	R:R:F89	4.478	5	0	7
9	R:R:Y90	12.418	5	2	5
10	R:R:Y94	7.1375	4	0	8
11	R:R:W98	7.13	5	0	5
12	R:R:L99	4.4675	4	0	8
13	R:R:L100	4.6425	4	1	8
14	R:R:Y108	4.8	4	0	8
15	R:R:W134	4.85	4	0	9
16	R:R:F138	4.1025	4	6	3
17	R:R:V144	4.5475	4	2	5
18	R:R:V147	3.868	5	3	4
19	R:R:Q148	4.84	4	0	5
20	R:R:Y165	7.0675	8	2	4
21	R:R:Q172	6.898	5	3	1
22	R:R:L177	1.6425	4	0	2
23	R:R:F188	10.8675	4	0	8
24	R:R:C198	3.9525	4	0	8
25	R:R:Y199	6.54	4	0	8
26	R:R:R201	4.562	5	0	4
27	R:R:V212	5.91	4	0	3
28	R:R:F231	6.1825	4	1	9
29	R:R:Y238	5.60667	6	2	7
30	R:R:H242	7.6675	4	2	6
31	R:R:V244	3.8775	4	0	5
32	R:R:W254	5.4675	4	0	4
33	R:R:R255	7.975	4	2	5
34	R:R:N265	9.48	5	1	9
35	R:R:D269	7.42	5	1	9
36	R:R:F273	5.154	5	1	9
37	W:W:?1	12.1391	11	1	0
38	W:W:?2	19.3525	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H242	R:R:S241	14.0384	2.79	Yes	No	0	6	5
2	R:R:S241	R:R:W254	13.3503	4.94	No	Yes	0	5	4
3	L:L:?1	R:R:L183	43.7899	4.76	Yes	No	0	0	5
4	R:R:L183	R:R:Y94	23.5335	11.72	No	Yes	0	5	8
5	R:R:L187	R:R:Y94	78.2009	8.21	No	Yes	0	6	8
6	R:R:L187	R:R:W98	100	6.83	No	Yes	0	6	5
7	R:R:W98	W:W:?2	98.8595	7.95	Yes	Yes	0	5	0
8	W:W:?1	W:W:?2	94.9885	49.55	Yes	Yes	1	0	0
9	R:R:L47	W:W:?1	68.7247	4.14	No	Yes	1	7	0
10	R:R:I103	R:R:L47	68.6901	4.28	No	No	1	9	7
11	R:R:F273	R:R:I103	65.3345	3.77	Yes	No	1	9	9
12	R:R:D269	R:R:F273	59.8957	4.78	Yes	Yes	1	9	9
13	R:R:D269	R:R:D55	32.3216	7.98	Yes	No	0	9	9
14	R:R:A266	R:R:D55	17.8402	4.63	No	No	0	8	9
15	R:R:A266	R:R:L58	16.6588	6.3	No	No	0	8	7
16	R:R:F89	R:R:L58	15.2701	8.53	Yes	No	0	7	7
17	R:R:F89	R:R:K65	10.1518	3.72	Yes	No	0	7	7
18	L:L:?1	R:R:Y238	23.2601	6.72	Yes	Yes	2	0	7
19	R:R:Y238	R:R:Y94	53.2033	3.97	Yes	Yes	0	7	8
20	R:R:H140	R:R:L183	21.554	7.71	No	No	0	4	5
21	R:R:H140	R:R:L187	22.3552	5.14	No	No	0	4	6
22	R:R:D269	R:R:N265	15.7256	12.12	Yes	Yes	1	9	9
23	R:R:N230	R:R:N265	15.003	13.62	No	Yes	1	7	9
24	R:R:L268	R:R:N230	13.8216	4.12	No	No	0	7	7
25	R:R:D55	R:R:N25	15.3895	6.73	No	Yes	0	9	9
26	R:R:L59	R:R:N25	11.1446	2.75	No	Yes	0	6	9
27	R:R:P43	W:W:?1	14.9182	4.91	No	Yes	0	7	0
28	R:R:A42	R:R:P43	10.7864	1.87	No	No	0	7	7
29	R:R:D269	R:R:L51	20.1244	6.79	Yes	Yes	1	9	9
30	R:R:L51	R:R:L99	19.8668	5.54	Yes	Yes	0	9	8
31	R:R:C95	R:R:L99	10.5854	3.17	No	Yes	0	7	8
32	L:L:?1	R:R:V144	13.6394	3.41	Yes	Yes	2	0	5
33	R:R:F87	R:R:V144	12.7125	5.24	No	Yes	0	6	5
34	R:R:F87	R:R:G88	11.1195	4.52	No	No	0	6	5
35	L:L:?1	R:R:Y165	46.3726	13.44	Yes	Yes	2	0	4
36	R:R:E166	R:R:Y165	30.9517	2.24	No	Yes	0	5	4
37	R:R:E166	R:R:W75	28.5795	5.45	No	Yes	0	5	9
38	R:R:C164	R:R:W75	12.1406	7.84	No	Yes	0	9	9
39	R:R:Q148	R:R:Y165	14.2552	7.89	Yes	Yes	0	5	4
40	R:R:N239	R:R:Y94	18.2047	4.65	No	Yes	0	8	8
41	R:R:L109	W:W:?1	25.4815	16.56	No	Yes	0	6	0
42	R:R:L109	R:R:Y108	24.5703	4.69	No	Yes	0	6	8
43	R:R:C198	R:R:Y108	14.4877	4.03	Yes	Yes	0	8	8
44	R:R:C198	R:R:S104	13.1492	5.16	Yes	No	0	8	9
45	R:R:R201	R:R:Y108	26.9928	5.14	Yes	Yes	0	4	8
46	R:R:I205	R:R:R201	21.9279	6.26	No	Yes	0	5	4
47	R:R:I205	R:R:V111	12.9858	1.54	No	No	0	5	8
48	R:R:F202	R:R:V111	11.6536	7.87	No	No	0	8	8
49	R:R:F168	R:R:Y165	16.5174	5.16	No	Yes	0	4	4
50	R:R:H242	R:R:Y238	12.1878	6.53	Yes	Yes	2	6	7
51	R:R:Y238	R:R:Y90	17.1018	9.93	Yes	Yes	2	7	5
52	R:R:Y165	R:R:Y90	15.4869	7.94	Yes	Yes	2	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y90	30.9	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:C141	3.64	2	Yes	No	0	7	0	1
L:L:?1	R:R:I143	6.54	2	Yes	No	0	7	0	1
L:L:?1	R:R:V144	3.41	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y165	13.44	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:R180	4.18	2	Yes	No	0	5	0	1
L:L:?1	R:R:L183	4.76	2	Yes	No	0	5	0	1
L:L:?1	R:R:Y238	6.72	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:H242	4.42	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:R255	11.14	2	Yes	Yes	0	5	0	1
R:R:S86	R:R:Y90	5.09	2	No	Yes	6	5	2	1
R:R:S86	R:R:V144	3.23	2	No	Yes	6	5	2	1
R:R:S86	R:R:Y165	6.36	2	No	Yes	6	4	2	1
R:R:F87	R:R:V144	5.24	0	No	Yes	6	5	2	1
R:R:Y165	R:R:Y90	7.94	2	Yes	Yes	4	5	1	1
R:R:Y238	R:R:Y90	9.93	2	Yes	Yes	7	5	1	1
R:R:R255	R:R:Y90	8.23	2	Yes	Yes	5	5	1	1
R:R:L183	R:R:Y94	11.72	0	No	Yes	5	8	1	2
R:R:Y238	R:R:Y94	3.97	2	Yes	Yes	7	8	1	2
R:R:H140	R:R:L183	7.71	0	No	No	4	5	2	1
R:R:I143	R:R:V179	7.68	0	No	No	7	4	1	2
R:R:V144	R:R:Y165	6.31	2	Yes	Yes	5	4	1	1
R:R:Q148	R:R:Y165	7.89	0	Yes	Yes	5	4	2	1
R:R:F168	R:R:Y165	5.16	0	No	Yes	4	4	2	1
R:R:R255	R:R:Y165	7.2	2	Yes	Yes	5	4	1	1
R:R:H242	R:R:R180	16.93	2	Yes	No	6	5	1	1
R:R:R180	R:R:R255	5.33	2	No	Yes	5	5	1	1
R:R:H242	R:R:Y238	6.53	2	Yes	Yes	6	7	1	1
R:R:S262	R:R:Y238	3.82	0	No	Yes	8	7	2	1
R:R:H242	R:R:S241	2.79	2	Yes	No	6	5	1	2
R:R:A258	R:R:Y238	2.67	0	No	Yes	7	7	2	1
R:R:E166	R:R:Y165	2.24	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P43	W:W:?1	4.91	0	No	Yes	7	0	2	1
R:R:E106	R:R:L47	5.3	1	No	No	8	7	2	2
R:R:L47	W:W:?1	4.14	1	No	Yes	7	0	2	1
R:R:V132	R:R:W98	3.68	0	No	Yes	4	5	2	1
R:R:L187	R:R:W98	6.83	0	No	Yes	6	5	2	1
R:R:P191	R:R:W98	14.86	0	No	Yes	9	5	2	1
R:R:W98	W:W:?2	7.95	0	Yes	Yes	5	0	1	0
R:R:E106	W:W:?1	6.61	1	No	Yes	8	0	2	1
R:R:L109	W:W:?1	16.56	0	No	Yes	6	0	2	1
R:R:F113	W:W:?1	7.29	0	No	Yes	6	0	2	1
R:R:Q116	W:W:?1	18.58	0	No	Yes	5	0	2	1
R:R:Y117	W:W:?1	7.01	0	No	Yes	5	0	2	1
R:R:S120	W:W:?1	5.99	0	No	Yes	4	0	2	1
R:R:R122	R:R:Y125	6.17	0	No	No	6	4	2	1
R:R:Y125	W:W:?1	8.18	1	No	Yes	4	0	1	1
R:R:Y125	W:W:?2	15.2	1	No	Yes	4	0	1	0
R:R:A129	W:W:?1	4.71	1	No	Yes	5	0	1	1
R:R:A129	W:W:?2	4.71	1	No	Yes	5	0	1	0
W:W:?1	W:W:?2	49.55	1	Yes	Yes	0	0	1	0
R:R:M136	R:R:W98	2.33	0	No	Yes	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P43	W:W:?1	4.91	0	No	Yes	7	0	1	0
R:R:E106	R:R:V44	8.56	1	No	No	8	7	1	2
R:R:I103	R:R:L47	4.28	1	No	No	9	7	2	1
R:R:E106	R:R:L47	5.3	1	No	No	8	7	1	1
R:R:L47	W:W:?1	4.14	1	No	Yes	7	0	1	0
R:R:W98	W:W:?2	7.95	0	Yes	Yes	5	0	2	1
R:R:E106	W:W:?1	6.61	1	No	Yes	8	0	1	0
R:R:L109	R:R:Y108	4.69	0	No	Yes	6	8	1	2
R:R:A112	R:R:Y108	5.34	0	No	Yes	7	8	2	2
R:R:L109	W:W:?1	16.56	0	No	Yes	6	0	1	0
R:R:G110	R:R:Y117	7.24	0	No	No	8	5	2	1
R:R:A112	R:R:F113	5.55	0	No	No	7	6	2	1
R:R:F113	W:W:?1	7.29	0	No	Yes	6	0	1	0
R:R:Q116	W:W:?1	18.58	0	No	Yes	5	0	1	0
R:R:R121	R:R:Y117	14.4	0	No	No	7	5	2	1
R:R:Y117	W:W:?1	7.01	0	No	Yes	5	0	1	0
R:R:L119	R:R:S120	3	0	No	No	4	4	2	1
R:R:S120	W:W:?1	5.99	0	No	Yes	4	0	1	0
R:R:R122	R:R:Y125	6.17	0	No	No	6	4	2	1
R:R:Y125	W:W:?1	8.18	1	No	Yes	4	0	1	0
R:R:Y125	W:W:?2	15.2	1	No	Yes	4	0	1	1
R:R:A129	W:W:?1	4.71	1	No	Yes	5	0	1	0
R:R:A129	W:W:?2	4.71	1	No	Yes	5	0	1	1
W:W:?1	W:W:?2	49.55	1	Yes	Yes	0	0	0	1
R:R:G126	R:R:P43	2.03	0	No	No	8	7	2	1
R:R:A42	R:R:P43	1.87	0	No	No	7	7	2	1
R:R:F113	R:R:P114	1.44	0	No	No	6	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9K1D_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	255
Number of Links	285
Number of Hubs	38
Number of Links mediated by Hubs	153
Number of Communities	6
Number of Nodes involved in Communities	43
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	53
Number Of Links MetaPath	52
Number of Shortest Paths	52065
Length Of Smallest Path	3
Average Path Length	13.7909
Length of Longest Path	28
Minimum Path Strength	1.295
Average Path Strength	8.00154
Maximum Path Strength	34.065
Minimum Path Correlation	0.7
Average Path Correlation	0.922213
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	44.7357
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.5524
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of response to biotic stimulus • immune response-regulating cell surface receptor signaling pathway • regulation of cellular process • response to stimulus • pattern recognition receptor signaling pathway • response to biotic stimulus • cell communication • immune response-activating signaling pathway • positive regulation of immune response • regulation of immune system process • signal transduction • positive regulation of immune system process • innate immune response-activating signaling pathway • regulation of biological process • immune response • response to other organism • immune response-activating cell surface receptor signaling pathway • regulation of innate immune response • response to external stimulus • regulation of response to stimulus • defense response to other organism • positive regulation of defense response • activation of innate immune response • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of response to external stimulus • signaling • positive regulation of biological process • innate immune response activating cell surface receptor signaling pathway • positive regulation of response to stimulus • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of response to stress • response to stress • innate immune response • response to external biotic stimulus • cell surface pattern recognition receptor signaling pathway • positive regulation of innate immune response • cell surface receptor signaling pathway • defense response • biological regulation • defense response to symbiont • immune system process • cellular process • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • regulation of cell communication • hormone transport • protein localization • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • cellular localization • regulation of protein localization • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • macromolecule localization • insulin secretion • multicellular organismal process • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of biosynthetic process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of interleukin-8 production • regulation of chemokine production • chemokine production • positive regulation of chemokine production • cell chemotaxis • leukocyte chemotaxis involved in inflammatory response • chemotaxis • leukocyte migration involved in inflammatory response • leukocyte migration • cellular response to chemical stimulus • taxis • response to chemical • cell migration • inflammatory response • cell motility • leukocyte chemotaxis • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • mucosal immune response • organ or tissue specific immune response • lipid storage • nutrient storage • positive regulation of acute inflammatory response • positive regulation of inflammatory response • regulation of acute inflammatory response to non-antigenic stimulus • acute inflammatory response • acute inflammatory response to non-antigenic stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response to non-antigenic stimulus • regulation of acute inflammatory response • response to lipid • response to fatty acid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to fatty acid • cellular response to lipid • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • regulation of immune effector process • positive regulation of immune effector process • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune effector process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to nitrogen compound • cell division • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • response to ketone • response to prostaglandin • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BUA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	BUA
Name	Butyric Acid
Synonyms	Butyrate
Identifier
Formula	C4 H8 O2
Molecular Weight	88.105
SMILES
PubChem	264
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	13
Total Aromatic Bonds	0


Code	CLR
PDB Residues	W:W:?1 W:W:?2
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>9K1D_nogp_Chain_R D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N F R W Y L P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T C Y E N F T D N Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q P L V G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F S S S V V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	Cholesterol	Gi1/β1/γ2	3.34	2024-12-11	10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	Cholesterol		3.34	2024-12-11	10.1016/j.celrep.2024.115024
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	10.1126/sciadv.adj2384
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	10.1038/s41422-023-00914-z
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	10.1038/s41422-023-00914-z

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