psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y90	30.9	Yes	Yes	1	0	5
2	L:L:?1	R:R:C141	3.64	Yes	No	0	0	7
3	L:L:?1	R:R:I143	6.54	Yes	No	0	0	7
4	L:L:?1	R:R:V144	3.41	Yes	Yes	1	0	5
5	L:L:?1	R:R:Y165	13.44	Yes	Yes	1	0	4
6	L:L:?1	R:R:R180	4.18	Yes	No	1	0	5
7	L:L:?1	R:R:L183	4.76	Yes	Yes	1	0	5
8	L:L:?1	R:R:Y238	6.72	Yes	Yes	1	0	7
9	L:L:?1	R:R:H242	4.42	Yes	Yes	1	0	6
10	L:L:?1	R:R:R255	11.14	Yes	Yes	1	0	5
11	R:R:D4	R:R:W5	21.22	No	No	0	4	7
12	R:R:D4	R:R:K6	2.77	No	Yes	0	4	5
13	R:R:F73	R:R:K6	7.44	No	Yes	0	4	5
14	R:R:K6	R:R:W253	4.64	Yes	No	0	5	1
15	R:R:K6	R:R:S256	6.12	Yes	No	0	5	4
16	R:R:I257	R:R:K6	7.27	No	Yes	0	5	5
17	R:R:N72	R:R:S7	4.47	No	No	0	3	3
18	R:R:I10	R:R:Y14	6.04	No	Yes	0	5	8
19	R:R:K65	R:R:Y14	5.97	No	Yes	0	7	8
20	R:R:I66	R:R:Y14	7.25	No	Yes	0	7	8
21	R:R:V260	R:R:Y14	5.05	No	Yes	0	5	8
22	R:R:I16	R:R:I17	2.94	No	Yes	0	5	7
23	R:R:I17	R:R:S263	3.1	Yes	No	0	7	6
24	R:R:I17	R:R:L264	4.28	Yes	No	0	7	5
25	R:R:I17	R:R:S267	4.64	Yes	No	0	7	8
26	R:R:F18	R:R:L22	3.65	No	No	0	7	6
27	R:R:F18	R:R:P63	2.89	No	No	0	7	9
28	R:R:L19	R:R:T20	2.95	No	No	0	4	5
29	R:R:G21	R:R:L59	5.13	No	No	0	8	6
30	R:R:L22	R:R:L59	8.3	No	No	0	6	6
31	R:R:A24	R:R:P270	3.74	No	No	0	7	9
32	R:R:N25	R:R:T52	5.85	Yes	No	0	9	8
33	R:R:D55	R:R:N25	6.73	Yes	Yes	0	9	9
34	R:R:N25	R:R:P270	13.03	Yes	No	0	9	9
35	R:R:F275	R:R:L27	3.65	No	No	0	7	6
36	R:R:A28	R:R:F32	2.77	No	No	0	8	7
37	R:R:L29	R:R:T52	4.42	No	No	0	7	8
38	R:R:A31	R:R:Y274	4	No	No	0	7	7
39	R:R:F32	R:R:L48	10.96	No	No	0	7	8
40	R:R:F32	R:R:T52	7.78	No	No	0	7	8
41	R:R:Q38	R:R:R35	9.35	No	No	0	5	5
42	R:R:H45	R:R:R35	22.57	No	No	0	7	5
43	R:R:P39	R:R:Q38	3.16	No	No	0	3	5
44	R:R:P123	R:R:P41	3.9	No	No	0	2	6
45	R:R:A42	R:R:H45	4.39	No	No	0	7	7
46	R:R:E106	R:R:V44	8.56	No	No	0	8	7
47	R:R:I46	R:R:V127	3.07	No	No	0	7	4
48	R:R:I103	R:R:L47	4.28	No	No	0	9	7
49	R:R:E106	R:R:L47	5.3	No	No	0	8	7
50	R:R:F273	R:R:L48	4.87	Yes	No	0	9	8
51	R:R:L49	R:R:L53	2.77	No	No	0	6	6
52	R:R:L99	R:R:S50	6.01	Yes	No	0	8	9
53	R:R:S50	R:R:W134	7.41	No	Yes	0	9	9
54	R:R:L51	R:R:S96	4.5	Yes	No	0	9	9
55	R:R:L51	R:R:L99	5.54	Yes	Yes	0	9	8
56	R:R:L100	R:R:L51	4.15	Yes	Yes	2	8	9
57	R:R:D269	R:R:L51	6.79	Yes	Yes	2	9	9
58	R:R:D55	R:R:S96	2.94	Yes	No	0	9	9
59	R:R:A266	R:R:D55	4.63	No	Yes	0	8	9
60	R:R:D269	R:R:D55	7.98	Yes	Yes	0	9	9
61	R:R:L56	R:R:L60	5.54	No	No	0	7	4
62	R:R:L57	R:R:L61	2.77	No	No	0	7	7
63	R:R:F89	R:R:L58	8.53	Yes	No	0	7	7
64	R:R:L58	R:R:S92	7.51	No	No	0	7	8
65	R:R:A266	R:R:L58	6.3	No	No	0	8	7
66	R:R:L61	R:R:T85	2.95	No	No	0	7	5
67	R:R:F64	R:R:T85	6.49	No	No	0	6	5
68	R:R:F89	R:R:K65	3.72	Yes	No	0	7	7
69	R:R:E68	R:R:W75	4.36	No	Yes	0	5	9
70	R:R:A69	R:R:F73	2.77	No	No	0	5	4
71	R:R:R74	R:R:S71	3.95	No	No	1	4	4
72	R:R:S71	R:R:Y76	6.36	No	No	1	4	3
73	R:R:R74	R:R:W75	7	No	Yes	1	4	9
74	R:R:R74	R:R:Y76	10.29	No	No	1	4	3
75	R:R:T163	R:R:W75	8.49	No	Yes	1	4	9
76	R:R:C164	R:R:W75	7.84	No	Yes	0	9	9
77	R:R:E166	R:R:W75	5.45	No	Yes	1	5	9
78	R:R:N167	R:R:W75	3.39	No	Yes	0	4	9
79	R:R:L77	R:R:P78	3.28	No	No	4	7	8
80	R:R:L77	R:R:V81	4.47	No	No	4	7	6
81	R:R:C82	R:R:L77	6.35	No	No	0	9	7
82	R:R:P78	R:R:V81	5.3	No	No	4	8	6
83	R:R:V80	R:R:Y149	6.31	No	No	0	4	5
84	R:R:C164	R:R:C82	5.46	No	No	0	9	9
85	R:R:A83	R:R:Q148	3.03	No	Yes	0	7	5
86	R:R:S86	R:R:Y90	5.09	No	Yes	1	6	5
87	R:R:S86	R:R:V144	3.23	No	Yes	1	6	5
88	R:R:S86	R:R:Y165	6.36	No	Yes	1	6	4
89	R:R:F87	R:R:G88	4.52	No	No	0	6	5
90	R:R:C141	R:R:F87	2.79	No	No	0	7	6
91	R:R:F87	R:R:V144	5.24	No	Yes	0	6	5
92	R:R:F89	R:R:I93	3.77	Yes	No	0	7	8
93	R:R:F89	R:R:V259	3.93	Yes	No	0	7	5
94	R:R:Y165	R:R:Y90	7.94	Yes	Yes	1	4	5
95	R:R:Y238	R:R:Y90	9.93	Yes	Yes	1	7	5
96	R:R:R255	R:R:Y90	8.23	Yes	Yes	1	5	5
97	R:R:S137	R:R:S91	4.89	No	No	5	7	5
98	R:R:F138	R:R:S91	7.93	Yes	No	5	3	5
99	R:R:L183	R:R:Y94	11.72	Yes	Yes	1	5	8
100	R:R:L187	R:R:Y94	8.21	Yes	Yes	1	6	8
101	R:R:Y238	R:R:Y94	3.97	Yes	Yes	1	7	8
102	R:R:N239	R:R:Y94	4.65	No	Yes	0	8	8
103	R:R:C95	R:R:L99	3.17	No	Yes	0	7	8
104	R:R:C95	R:R:W134	7.84	No	Yes	0	7	9
105	R:R:C95	R:R:S137	3.44	No	No	0	7	7
106	R:R:F231	R:R:T97	6.49	Yes	No	2	9	8
107	R:R:F235	R:R:T97	14.27	No	No	2	9	8
108	R:R:V132	R:R:W98	3.68	No	Yes	0	4	5
109	R:R:L187	R:R:W98	6.83	Yes	Yes	0	6	5
110	R:R:P191	R:R:W98	14.86	No	Yes	0	9	5
111	R:R:A133	R:R:L99	3.15	No	Yes	0	7	8
112	R:R:F231	R:R:L100	4.87	Yes	Yes	2	9	8
113	R:R:L100	R:R:N265	4.12	Yes	Yes	2	8	9
114	R:R:D269	R:R:L100	5.43	Yes	Yes	2	9	8
115	R:R:I103	R:R:R107	5.01	No	No	2	9	9
116	R:R:F273	R:R:I103	3.77	Yes	No	2	9	9
117	R:R:S104	R:R:T195	7.99	No	No	0	9	7
118	R:R:C198	R:R:S104	5.16	Yes	No	0	8	9
119	R:R:S104	R:R:Y199	5.09	No	Yes	0	9	8
120	R:R:I105	R:R:L109	2.85	No	No	0	6	6
121	R:R:C198	R:R:I105	4.91	Yes	No	0	8	6
122	R:R:R107	R:R:Y199	4.12	No	Yes	0	9	8
123	R:R:F273	R:R:R107	7.48	Yes	No	2	9	9
124	R:R:L109	R:R:Y108	4.69	No	Yes	0	6	8
125	R:R:A112	R:R:Y108	5.34	No	Yes	0	7	8
126	R:R:C198	R:R:Y108	4.03	Yes	Yes	0	8	8
127	R:R:R201	R:R:Y108	5.14	Yes	Yes	0	4	8
128	R:R:G110	R:R:Y117	7.24	No	No	0	8	5
129	R:R:F202	R:R:V111	7.87	No	No	0	8	8
130	R:R:A112	R:R:F113	5.55	No	No	0	7	6
131	R:R:R121	R:R:Y117	14.4	No	No	0	7	5
132	R:R:L119	R:R:S120	3	No	No	0	4	4
133	R:R:P123	R:R:R122	15.85	No	No	0	2	6
134	R:R:L124	R:R:R122	6.07	No	No	0	3	6
135	R:R:R122	R:R:Y125	6.17	No	No	0	6	4
136	R:R:F138	R:R:W134	3.01	Yes	Yes	0	3	9
137	R:R:F138	R:R:S137	3.96	Yes	No	5	3	7
138	R:R:E182	R:R:H140	4.92	No	Yes	1	4	4
139	R:R:H140	R:R:L183	7.71	Yes	Yes	1	4	5
140	R:R:H140	R:R:V186	2.77	Yes	No	1	4	4
141	R:R:H140	R:R:L187	5.14	Yes	Yes	1	4	6
142	R:R:I143	R:R:V179	7.68	No	No	0	7	4
143	R:R:V144	R:R:Y165	6.31	Yes	Yes	1	5	4
144	R:R:I146	R:R:V147	3.07	No	Yes	0	4	4
145	R:R:Q148	R:R:V147	5.73	Yes	Yes	0	5	4
146	R:R:Q172	R:R:V147	5.73	Yes	Yes	3	1	4
147	R:R:V147	R:R:V176	3.21	Yes	No	3	4	4
148	R:R:Q148	R:R:Y165	7.89	Yes	Yes	0	5	4
149	R:R:L150	R:R:N171	5.49	No	No	3	2	3
150	R:R:L150	R:R:Q172	3.99	No	Yes	3	2	1
151	R:R:E166	R:R:T163	2.82	No	No	1	5	4
152	R:R:F168	R:R:Y165	5.16	No	Yes	0	4	4
153	R:R:R255	R:R:Y165	7.2	Yes	Yes	1	5	4
154	R:R:F168	R:R:Q172	7.03	No	Yes	0	4	1
155	R:R:F168	R:R:V176	7.87	No	No	0	4	4
156	R:R:N171	R:R:T169	5.85	No	No	3	3	4
157	R:R:Q172	R:R:T169	8.5	Yes	No	3	1	4
158	R:R:N171	R:R:Q172	9.24	No	Yes	3	3	1
159	R:R:H242	R:R:R180	16.93	Yes	No	1	6	5
160	R:R:R180	R:R:R255	5.33	No	Yes	1	5	5
161	R:R:L181	R:R:L243	2.77	No	No	0	5	5
162	R:R:L181	R:R:Y246	8.21	No	No	0	5	4
163	R:R:E182	R:R:V186	2.85	No	No	1	4	4
164	R:R:L183	R:R:L187	2.77	Yes	Yes	1	5	6
165	R:R:C184	R:R:F189	2.79	Yes	No	0	6	4
166	R:R:C184	R:R:N239	4.72	Yes	No	0	6	8
167	R:R:C184	R:R:H242	2.95	Yes	Yes	0	6	6
168	R:R:F189	R:R:L185	6.09	No	No	0	4	5
169	R:R:F188	R:R:F189	4.29	Yes	No	0	8	4
170	R:R:F188	R:R:M192	7.46	Yes	No	0	8	6
171	R:R:F188	R:R:N239	30.21	Yes	No	0	8	8
172	R:R:I190	R:R:P191	3.39	No	No	0	5	9
173	R:R:I196	R:R:M192	4.37	No	No	0	4	6
174	R:R:F231	R:R:T195	9.08	Yes	No	0	9	7
175	R:R:I196	R:R:L232	5.71	No	No	0	4	5
176	R:R:F197	R:R:R201	6.41	No	Yes	0	5	4
177	R:R:T227	R:R:Y199	8.74	No	Yes	0	7	8
178	R:R:L228	R:R:Y199	8.21	No	Yes	0	8	8
179	R:R:R201	R:R:W200	4	Yes	No	0	4	3
180	R:R:I205	R:R:R201	6.26	No	Yes	0	5	4
181	R:R:F202	R:R:M206	6.22	No	No	0	8	8
182	R:R:A224	R:R:F202	2.77	No	No	0	7	8
183	R:R:A220	R:R:M206	3.22	No	No	0	7	8
184	R:R:M206	R:R:V221	3.04	No	No	0	8	4
185	R:R:L207	R:R:V221	2.98	No	No	0	4	4
186	R:R:P210	R:R:Q209	7.9	No	No	0	3	5
187	R:R:Q209	R:R:V212	10.03	No	Yes	0	5	3
188	R:R:R217	R:R:V212	9.15	No	Yes	0	6	3
189	R:R:Q215	R:R:R219	12.85	No	No	0	4	7
190	R:R:L223	R:R:S276	6.01	No	No	0	7	7
191	R:R:L272	R:R:T227	2.95	Yes	No	0	8	7
192	R:R:L228	R:R:L232	2.77	No	No	0	8	5
193	R:R:C234	R:R:N230	4.72	No	No	2	8	7
194	R:R:N230	R:R:N265	13.62	No	Yes	2	7	9
195	R:R:L268	R:R:N230	4.12	Yes	No	0	7	7
196	R:R:F231	R:R:F235	4.29	Yes	No	2	9	9
197	R:R:C234	R:R:N265	7.87	No	Yes	2	8	9
198	R:R:F235	R:R:N265	9.67	No	Yes	2	9	9
199	R:R:G236	R:R:P237	4.06	No	No	0	5	9
200	R:R:H242	R:R:Y238	6.53	Yes	Yes	1	6	7
201	R:R:S262	R:R:Y238	3.82	No	Yes	0	8	7
202	R:R:H242	R:R:S241	2.79	Yes	No	0	6	5
203	R:R:S241	R:R:W254	4.94	No	Yes	0	5	4
204	R:R:G245	R:R:V244	3.68	No	Yes	0	5	5
205	R:R:Q248	R:R:V244	2.87	No	Yes	0	3	5
206	R:R:V244	R:R:W254	7.36	Yes	Yes	0	5	4
207	R:R:G245	R:R:P252	4.06	No	No	0	5	1
208	R:R:K250	R:R:Q248	4.07	No	No	0	2	3
209	R:R:P252	R:R:S251	3.56	No	No	0	1	4
210	R:R:P252	R:R:W254	6.76	No	Yes	0	1	4
211	R:R:W253	R:R:W254	2.81	No	Yes	0	1	4
212	R:R:L264	R:R:L268	2.77	No	Yes	0	5	7
213	R:R:D269	R:R:N265	12.12	Yes	Yes	2	9	9
214	R:R:L268	R:R:L271	4.15	Yes	No	0	7	7
215	R:R:L268	R:R:L272	2.77	Yes	Yes	0	7	8
216	R:R:D269	R:R:F273	4.78	Yes	Yes	2	9	9
217	R:R:F275	R:R:L271	3.65	No	No	0	7	7
218	R:R:F273	R:R:L272	4.87	Yes	Yes	0	9	8
219	R:R:S278	R:R:V279	3.23	No	No	0	4	5
220	R:R:L59	R:R:N25	2.75	No	Yes	0	6	9
221	R:R:K79	R:R:Q148	2.71	No	Yes	0	2	5
222	R:R:A28	R:R:Y274	2.67	No	No	0	8	7
223	R:R:A258	R:R:Y238	2.67	No	Yes	0	7	7
224	R:R:H45	R:R:I36	2.65	No	No	0	7	5
225	R:R:R219	R:R:S277	2.64	No	No	0	7	8
226	R:R:R216	R:R:V212	2.62	No	Yes	0	5	3
227	R:R:F89	R:R:L62	2.44	Yes	No	0	7	8
228	R:R:I145	R:R:Y149	2.42	No	No	0	4	5
229	R:R:Q40	R:R:R121	2.34	No	No	0	5	7
230	R:R:F113	R:R:Q116	2.34	No	No	0	6	5
231	R:R:L177	R:R:Y246	2.34	Yes	No	0	2	4
232	R:R:M136	R:R:W98	2.33	No	Yes	0	4	5
233	R:R:E166	R:R:Y165	2.24	No	Yes	1	5	4
234	R:R:G21	R:R:P23	2.03	No	No	0	8	4
235	R:R:G126	R:R:P43	2.03	No	No	0	8	7
236	R:R:A101	R:R:G102	1.95	No	No	0	8	6
237	R:R:A42	R:R:P43	1.87	No	No	0	7	7
238	R:R:A101	R:R:P191	1.87	No	No	0	8	9
239	R:R:G34	R:R:V33	1.84	No	No	0	4	4
240	R:R:G213	R:R:V212	1.84	No	Yes	0	4	3
241	R:R:G222	R:R:V225	1.84	No	No	0	5	5
242	R:R:G21	R:R:T20	1.82	No	No	0	8	5
243	R:R:G126	R:R:I46	1.76	No	No	0	8	7
244	R:R:A130	R:R:S50	1.71	No	No	0	7	9
245	R:R:A54	R:R:S92	1.71	No	No	0	8	8
246	R:R:A54	R:R:S96	1.71	No	No	0	8	9
247	R:R:G88	R:R:L61	1.71	No	No	0	5	7
248	R:R:C198	R:R:V194	1.71	Yes	No	0	8	6
249	R:R:A13	R:R:V260	1.7	No	No	0	4	5
250	R:R:A42	R:R:V44	1.7	No	No	0	7	7
251	R:R:A224	R:R:V203	1.7	No	No	0	7	5
252	R:R:I36	R:R:P41	1.69	No	No	0	5	6
253	R:R:I46	R:R:P123	1.69	No	No	0	7	2
254	R:R:G34	R:R:Q38	1.64	No	No	0	4	5
255	R:R:L177	R:R:P178	1.64	Yes	No	0	2	2
256	R:R:A193	R:R:M192	1.61	No	No	0	3	6
257	R:R:V147	R:R:V175	1.6	Yes	No	3	4	3
258	R:R:V175	R:R:V176	1.6	No	No	3	3	4
259	R:R:V221	R:R:V225	1.6	No	No	0	4	5
260	R:R:V240	R:R:V244	1.6	No	Yes	0	6	5
261	R:R:C184	R:R:L243	1.59	Yes	No	0	6	5
262	R:R:A13	R:R:L9	1.58	No	No	0	4	6
263	R:R:A70	R:R:L11	1.58	No	No	0	4	5
264	R:R:P41	R:R:Q40	1.58	No	No	0	6	5
265	R:R:I205	R:R:V111	1.54	No	No	0	5	8
266	R:R:F138	R:R:G139	1.51	Yes	No	0	3	4
267	R:R:F188	R:R:G236	1.51	Yes	No	0	8	5
268	R:R:L9	R:R:S8	1.5	No	No	0	6	5
269	R:R:L49	R:R:V33	1.49	No	No	0	6	4
270	R:R:L119	R:R:V115	1.49	No	No	0	4	6
271	R:R:L272	R:R:V226	1.49	Yes	No	0	8	5
272	R:R:L84	R:R:T85	1.47	No	No	0	5	5
273	R:R:F113	R:R:P114	1.44	No	No	0	6	8
274	R:R:F261	R:R:P237	1.44	No	No	0	7	9
275	R:R:L22	R:R:L26	1.38	No	No	0	6	4
276	R:R:L29	R:R:L56	1.38	No	No	0	7	7
277	R:R:L173	R:R:L177	1.38	No	Yes	0	1	2
278	R:R:I205	R:R:Q209	1.37	No	No	0	5	5
279	R:R:D170	R:R:D174	1.33	No	No	0	1	1
280	R:R:F275	R:R:V279	1.31	No	No	0	7	5
281	R:R:K118	R:R:R121	1.24	No	No	0	4	7
282	R:R:H247	R:R:Q248	1.24	No	No	0	4	3
283	R:R:L177	R:R:R249	1.21	Yes	No	0	2	4
284	R:R:L223	R:R:R219	1.21	No	No	0	7	7
285	R:R:L131	R:R:W134	1.14	No	Yes	0	4	9
286	R:R:R30	R:R:R37	1.07	No	No	0	4	5
287	R:R:R201	R:R:W204	1	Yes	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.915	10	1	0
2	R:R:K6	5.648	5	0	5
3	R:R:Y14	6.0775	4	0	8
4	R:R:I17	3.74	4	0	7
5	R:R:N25	7.09	4	0	9
6	R:R:L51	5.245	4	2	9
7	R:R:D55	5.57	4	0	9
8	R:R:W75	6.08833	6	1	9
9	R:R:F89	4.478	5	0	7
10	R:R:Y90	12.418	5	1	5
11	R:R:Y94	7.1375	4	1	8
12	R:R:W98	6.925	4	0	5
13	R:R:L99	4.4675	4	0	8
14	R:R:L100	4.6425	4	2	8
15	R:R:Y108	4.8	4	0	8
16	R:R:W134	4.85	4	0	9
17	R:R:F138	4.1025	4	5	3
18	R:R:H140	5.135	4	1	4
19	R:R:V144	4.5475	4	1	5
20	R:R:V147	3.868	5	3	4
21	R:R:Q148	4.84	4	0	5
22	R:R:Y165	7.0675	8	1	4
23	R:R:Q172	6.898	5	3	1
24	R:R:L177	1.6425	4	0	2
25	R:R:L183	6.74	4	1	5
26	R:R:C184	3.0125	4	0	6
27	R:R:L187	5.7375	4	1	6
28	R:R:F188	10.8675	4	0	8
29	R:R:C198	3.9525	4	0	8
30	R:R:Y199	6.54	4	0	8
31	R:R:R201	4.562	5	0	4
32	R:R:V212	5.91	4	0	3
33	R:R:F231	6.1825	4	2	9
34	R:R:Y238	5.60667	6	1	7
35	R:R:H242	6.724	5	1	6
36	R:R:V244	3.8775	4	0	5
37	R:R:W254	5.4675	4	0	4
38	R:R:R255	7.975	4	1	5
39	R:R:N265	9.48	5	2	9
40	R:R:L268	3.4525	4	0	7
41	R:R:D269	7.42	5	2	9
42	R:R:L272	3.02	4	0	8
43	R:R:F273	5.154	5	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H242	35.5116	4.42	Yes	Yes	1	0	6
2	R:R:H242	R:R:S241	16.4941	2.79	Yes	No	0	6	5
3	R:R:S241	R:R:W254	15.6585	4.94	No	Yes	0	5	4
4	L:L:?1	R:R:L183	17.961	4.76	Yes	Yes	1	0	5
5	R:R:L183	R:R:Y94	17.538	11.72	Yes	Yes	1	5	8
6	R:R:N239	R:R:Y94	48.9351	4.65	No	Yes	0	8	8
7	R:R:F188	R:R:N239	74.6138	30.21	Yes	No	0	8	8
8	R:R:F188	R:R:M192	100	7.46	Yes	No	0	8	6
9	R:R:I196	R:R:M192	99.377	4.37	No	No	0	4	6
10	R:R:I196	R:R:L232	99.0592	5.71	No	No	0	4	5
11	R:R:L228	R:R:L232	98.7372	2.77	No	No	0	8	5
12	R:R:L228	R:R:Y199	98.3921	8.21	No	Yes	0	8	8
13	R:R:R107	R:R:Y199	68.6871	4.12	No	Yes	0	9	8
14	R:R:F273	R:R:R107	45.3403	7.48	Yes	No	2	9	9
15	R:R:D269	R:R:F273	44.4458	4.78	Yes	Yes	2	9	9
16	R:R:D269	R:R:D55	29.3114	7.98	Yes	Yes	0	9	9
17	R:R:A266	R:R:D55	15.4102	4.63	No	Yes	0	8	9
18	R:R:A266	R:R:L58	14.3831	6.3	No	No	0	8	7
19	R:R:F89	R:R:L58	13.0425	8.53	Yes	No	0	7	7
20	L:L:?1	R:R:Y238	16.3404	6.72	Yes	Yes	1	0	7
21	R:R:Y238	R:R:Y94	27.7729	3.97	Yes	Yes	1	7	8
22	R:R:C184	R:R:H242	48.3563	2.95	Yes	Yes	0	6	6
23	R:R:C184	R:R:N239	26.4722	4.72	Yes	No	0	6	8
24	R:R:C184	R:R:F189	26.4196	2.79	Yes	No	0	6	4
25	R:R:F188	R:R:F189	26.7226	4.29	Yes	No	0	8	4
26	R:R:T227	R:R:Y199	11.4514	8.74	No	Yes	0	7	8
27	R:R:L272	R:R:T227	10.8957	2.95	Yes	No	0	8	7
28	R:R:L268	R:R:L272	11.7144	2.77	Yes	Yes	0	7	8
29	R:R:D55	R:R:N25	13.1772	6.73	Yes	Yes	0	9	9
30	R:R:I103	R:R:R107	22.9196	5.01	No	No	2	9	9
31	R:R:I103	R:R:L47	27.8107	4.28	No	No	0	9	7
32	R:R:E106	R:R:L47	26.9626	5.3	No	No	0	8	7
33	R:R:E106	R:R:V44	26.1207	8.56	No	No	0	8	7
34	R:R:A42	R:R:V44	25.2683	1.7	No	No	0	7	7
35	R:R:A42	R:R:H45	17.1528	4.39	No	No	0	7	7
36	R:R:H45	R:R:I36	10.0539	2.65	No	No	0	7	5
37	R:R:D269	R:R:L51	17.8979	6.79	Yes	Yes	2	9	9
38	R:R:L51	R:R:L99	18.2451	5.54	Yes	Yes	0	9	8
39	R:R:S104	R:R:Y199	29.6165	5.09	No	Yes	0	9	8
40	L:L:?1	R:R:C141	11.9165	3.64	Yes	No	0	0	7
41	R:R:C141	R:R:F87	10.3885	2.79	No	No	0	7	6
42	R:R:F87	R:R:G88	18.2073	4.52	No	No	0	6	5
43	R:R:G88	R:R:L61	15.1829	1.71	No	No	0	5	7
44	L:L:?1	R:R:V144	11.7923	3.41	Yes	Yes	1	0	5
45	R:R:F87	R:R:V144	10.8452	5.24	No	Yes	0	6	5
46	L:L:?1	R:R:Y165	39.7272	13.44	Yes	Yes	1	0	4
47	R:R:E166	R:R:Y165	24.3276	2.24	No	Yes	1	5	4
48	R:R:E166	R:R:W75	20.5771	5.45	No	Yes	1	5	9
49	R:R:Q148	R:R:Y165	11.2935	7.89	Yes	Yes	0	5	4
50	R:R:C198	R:R:S104	29.3471	5.16	Yes	No	0	8	9
51	R:R:C198	R:R:Y108	25.7587	4.03	Yes	Yes	0	8	8
52	R:R:R201	R:R:Y108	20.2614	5.14	Yes	Yes	0	4	8
53	R:R:I205	R:R:R201	16.473	6.26	No	Yes	0	5	4
54	R:R:F168	R:R:Y165	13.0004	5.16	No	Yes	0	4	4
55	R:R:Y238	R:R:Y90	10.5464	9.93	Yes	Yes	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y90	30.9	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:C141	3.64	1	Yes	No	0	7	0	1
L:L:?1	R:R:I143	6.54	1	Yes	No	0	7	0	1
L:L:?1	R:R:V144	3.41	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y165	13.44	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R180	4.18	1	Yes	No	0	5	0	1
L:L:?1	R:R:L183	4.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y238	6.72	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:H242	4.42	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R255	11.14	1	Yes	Yes	0	5	0	1
R:R:S86	R:R:Y90	5.09	1	No	Yes	6	5	2	1
R:R:S86	R:R:V144	3.23	1	No	Yes	6	5	2	1
R:R:S86	R:R:Y165	6.36	1	No	Yes	6	4	2	1
R:R:C141	R:R:F87	2.79	0	No	No	7	6	1	2
R:R:F87	R:R:V144	5.24	0	No	Yes	6	5	2	1
R:R:Y165	R:R:Y90	7.94	1	Yes	Yes	4	5	1	1
R:R:Y238	R:R:Y90	9.93	1	Yes	Yes	7	5	1	1
R:R:R255	R:R:Y90	8.23	1	Yes	Yes	5	5	1	1
R:R:L183	R:R:Y94	11.72	1	Yes	Yes	5	8	1	2
R:R:L187	R:R:Y94	8.21	1	Yes	Yes	6	8	2	2
R:R:Y238	R:R:Y94	3.97	1	Yes	Yes	7	8	1	2
R:R:H140	R:R:L183	7.71	1	Yes	Yes	4	5	2	1
R:R:H140	R:R:L187	5.14	1	Yes	Yes	4	6	2	2
R:R:I143	R:R:V179	7.68	0	No	No	7	4	1	2
R:R:V144	R:R:Y165	6.31	1	Yes	Yes	5	4	1	1
R:R:Q148	R:R:Y165	7.89	0	Yes	Yes	5	4	2	1
R:R:F168	R:R:Y165	5.16	0	No	Yes	4	4	2	1
R:R:R255	R:R:Y165	7.2	1	Yes	Yes	5	4	1	1
R:R:H242	R:R:R180	16.93	1	Yes	No	6	5	1	1
R:R:R180	R:R:R255	5.33	1	No	Yes	5	5	1	1
R:R:L183	R:R:L187	2.77	1	Yes	Yes	5	6	1	2
R:R:C184	R:R:H242	2.95	0	Yes	Yes	6	6	2	1
R:R:H242	R:R:Y238	6.53	1	Yes	Yes	6	7	1	1
R:R:S262	R:R:Y238	3.82	0	No	Yes	8	7	2	1
R:R:H242	R:R:S241	2.79	1	Yes	No	6	5	1	2
R:R:A258	R:R:Y238	2.67	0	No	Yes	7	7	2	1
R:R:E166	R:R:Y165	2.24	1	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9K1D_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	252
Number of Links	287
Number of Hubs	43
Number of Links mediated by Hubs	156
Number of Communities	5
Number of Nodes involved in Communities	46
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	67951
Length Of Smallest Path	3
Average Path Length	16.8363
Length of Longest Path	30
Minimum Path Strength	1.295
Average Path Strength	6.09859
Maximum Path Strength	18.835
Minimum Path Correlation	0.7
Average Path Correlation	0.923134
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	41.7436
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.8422
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lipid binding • positive regulation of response to biotic stimulus • immune response-regulating cell surface receptor signaling pathway • pattern recognition receptor signaling pathway • response to biotic stimulus • immune response-activating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • innate immune response-activating signaling pathway • immune response • response to other organism • immune response-activating cell surface receptor signaling pathway • regulation of innate immune response • response to external stimulus • regulation of response to stimulus • defense response to other organism • positive regulation of defense response • activation of innate immune response • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of response to external stimulus • innate immune response activating cell surface receptor signaling pathway • positive regulation of response to stimulus • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of response to stress • response to stress • innate immune response • response to external biotic stimulus • cell surface pattern recognition receptor signaling pathway • positive regulation of innate immune response • defense response • defense response to symbiont • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of interleukin-8 production • regulation of chemokine production • chemokine production • positive regulation of chemokine production • cell chemotaxis • leukocyte chemotaxis involved in inflammatory response • chemotaxis • leukocyte migration involved in inflammatory response • taxis • inflammatory response • leukocyte chemotaxis • locomotion • fat cell differentiation • cellular developmental process • cell differentiation • mucosal immune response • organ or tissue specific immune response • lipid storage • nutrient storage • positive regulation of acute inflammatory response • positive regulation of inflammatory response • regulation of acute inflammatory response to non-antigenic stimulus • acute inflammatory response • acute inflammatory response to non-antigenic stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response to non-antigenic stimulus • regulation of acute inflammatory response • response to fatty acid • cellular response to fatty acid • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • regulation of immune effector process • positive regulation of immune effector process • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune effector process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BUA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	BUA
Name	Butyric Acid
Synonyms	α-keto-γ-methylselenobutyrate
Identifier
Formula	C4 H8 O2
Molecular Weight	88.105
SMILES
PubChem	264
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	13
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>9K1D_nogp_Chain_R D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N F R W Y L P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T C Y E N F T D N Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q P L V G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F S S S V V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	Gi1/β1/γ2	3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8Y6W	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	Gi1/β1/γ2	3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6W (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6Y	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	GLPG0974	-	-	3.36	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	9CLW	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CLW (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729	Gi1/β1/γ2	3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729		3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	Gi1/β1/γ2	3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6

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