psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y90	12.59	Yes	Yes	1	0	5
2	L:L:?1	R:R:C141	3.41	Yes	No	0	0	7
3	L:L:?1	R:R:V144	12.8	Yes	No	0	0	5
4	L:L:?1	R:R:I145	7.15	Yes	No	1	0	4
5	L:L:?1	R:R:Q148	7.62	Yes	Yes	1	0	5
6	L:L:?1	R:R:Y165	10.07	Yes	Yes	1	0	4
7	L:L:?1	R:R:Q172	6.67	Yes	No	0	0	1
8	L:L:?1	R:R:V175	7.46	Yes	No	0	0	3
9	L:L:?1	R:R:V176	7.46	Yes	Yes	1	0	4
10	L:L:?1	R:R:R180	15.65	Yes	Yes	1	0	5
11	L:L:?1	R:R:L183	3.96	Yes	No	0	0	5
12	L:L:?1	R:R:Y238	5.87	Yes	Yes	1	0	7
13	L:L:?1	R:R:R255	3.48	Yes	Yes	1	0	5
14	R:R:D4	R:R:K6	4.15	No	Yes	0	4	5
15	R:R:D4	R:R:S7	8.83	No	No	0	4	3
16	R:R:I10	R:R:K6	4.36	No	Yes	0	5	5
17	R:R:K6	R:R:W253	4.64	Yes	No	0	5	1
18	R:R:I257	R:R:K6	4.36	No	Yes	0	5	5
19	R:R:I10	R:R:Y14	3.63	No	Yes	0	5	8
20	R:R:L62	R:R:Y14	4.69	Yes	Yes	0	8	8
21	R:R:K65	R:R:Y14	9.55	Yes	Yes	0	7	8
22	R:R:V260	R:R:Y14	5.05	No	Yes	0	5	8
23	R:R:I17	R:R:S263	4.64	No	No	0	7	6
24	R:R:I17	R:R:L264	4.28	No	No	0	7	5
25	R:R:F18	R:R:L22	9.74	No	Yes	0	7	6
26	R:R:F18	R:R:L62	4.87	No	Yes	0	7	8
27	R:R:F18	R:R:P63	10.11	No	No	0	7	9
28	R:R:L22	R:R:P23	3.28	Yes	No	0	6	4
29	R:R:A24	R:R:P270	3.74	No	No	0	7	9
30	R:R:D55	R:R:N25	16.16	No	No	3	9	9
31	R:R:L59	R:R:N25	5.49	No	No	3	6	9
32	R:R:N25	R:R:P270	13.03	No	No	0	9	9
33	R:R:F275	R:R:L27	3.65	No	No	0	7	6
34	R:R:A28	R:R:Y274	4	No	Yes	0	8	7
35	R:R:L29	R:R:L53	5.54	No	No	0	7	6
36	R:R:A31	R:R:Y274	5.34	No	Yes	0	7	7
37	R:R:F32	R:R:L48	6.09	No	Yes	0	7	8
38	R:R:F32	R:R:T52	5.19	No	No	0	7	8
39	R:R:F32	R:R:Y274	7.22	No	Yes	0	7	7
40	R:R:Q38	R:R:R35	4.67	No	No	0	5	5
41	R:R:H45	R:R:R35	18.05	No	No	0	7	5
42	R:R:P123	R:R:P41	5.84	Yes	No	4	2	6
43	R:R:A42	R:R:H45	4.39	No	No	0	7	7
44	R:R:A42	R:R:R121	6.91	No	Yes	0	7	7
45	R:R:E106	R:R:P43	9.43	No	No	0	8	7
46	R:R:P43	R:R:R121	7.21	No	Yes	0	7	7
47	R:R:H45	R:R:V44	6.92	No	No	0	7	7
48	R:R:E106	R:R:V44	8.56	No	No	0	8	7
49	R:R:G126	R:R:I46	3.53	No	Yes	0	8	7
50	R:R:A129	R:R:L47	4.73	No	No	0	5	7
51	R:R:F273	R:R:L48	6.09	No	Yes	0	9	8
52	R:R:L49	R:R:L53	6.92	No	No	0	6	6
53	R:R:L99	R:R:S50	6.01	No	No	0	8	9
54	R:R:A130	R:R:S50	3.42	No	No	0	7	9
55	R:R:L100	R:R:L51	8.3	No	No	1	8	9
56	R:R:D269	R:R:L51	10.86	Yes	No	1	9	9
57	R:R:D55	R:R:L59	4.07	No	No	3	9	6
58	R:R:A266	R:R:D55	6.18	No	No	0	8	9
59	R:R:L56	R:R:L60	4.15	No	No	2	7	4
60	R:R:L57	R:R:L61	4.15	No	No	0	7	7
61	R:R:L58	R:R:L62	4.15	Yes	Yes	1	7	8
62	R:R:F89	R:R:L58	8.53	Yes	Yes	1	7	7
63	R:R:L58	R:R:S92	4.5	Yes	No	0	7	8
64	R:R:L58	R:R:S263	4.5	Yes	No	0	7	6
65	R:R:F64	R:R:L61	4.87	No	No	0	6	7
66	R:R:F89	R:R:L62	3.65	Yes	Yes	1	7	8
67	R:R:F64	R:R:T85	12.97	No	No	0	6	5
68	R:R:E68	R:R:K65	13.5	No	Yes	0	5	7
69	R:R:F89	R:R:K65	7.44	Yes	Yes	1	7	7
70	R:R:K65	R:R:Y90	3.58	Yes	Yes	1	7	5
71	R:R:I66	R:R:I67	4.42	No	No	0	7	4
72	R:R:E68	R:R:Y76	12.35	No	Yes	0	5	3
73	R:R:A69	R:R:F73	4.16	No	No	0	5	4
74	R:R:N72	R:R:R74	8.44	No	No	0	3	4
75	R:R:P78	R:R:Y76	4.17	No	Yes	5	8	3
76	R:R:V81	R:R:Y76	3.79	No	Yes	5	6	3
77	R:R:P78	R:R:V81	5.3	No	No	5	8	6
78	R:R:L84	R:R:V80	4.47	No	No	0	5	4
79	R:R:T85	R:R:V81	4.76	No	No	0	5	6
80	R:R:C164	R:R:C82	7.28	No	No	0	9	9
81	R:R:A83	R:R:Y165	5.34	No	Yes	0	7	4
82	R:R:S86	R:R:Y90	3.82	No	Yes	0	6	5
83	R:R:F87	R:R:T142	7.78	No	No	0	6	4
84	R:R:F89	R:R:Y90	6.19	Yes	Yes	1	7	5
85	R:R:F89	R:R:I93	3.77	Yes	Yes	1	7	8
86	R:R:F89	R:R:V259	6.55	Yes	No	1	7	5
87	R:R:Y238	R:R:Y90	4.96	Yes	Yes	1	7	5
88	R:R:R255	R:R:Y90	4.12	Yes	Yes	1	5	5
89	R:R:V259	R:R:Y90	6.31	No	Yes	1	5	5
90	R:R:F138	R:R:S91	10.57	No	No	0	3	5
91	R:R:C141	R:R:S91	3.44	No	No	0	7	5
92	R:R:F235	R:R:I93	5.02	Yes	Yes	1	9	8
93	R:R:I93	R:R:Y238	3.63	Yes	Yes	1	8	7
94	R:R:I93	R:R:S262	7.74	Yes	No	1	8	8
95	R:R:L183	R:R:Y94	5.86	No	Yes	0	5	8
96	R:R:L187	R:R:Y94	4.69	No	Yes	0	6	8
97	R:R:Y238	R:R:Y94	10.92	Yes	Yes	1	7	8
98	R:R:N239	R:R:Y94	12.79	Yes	Yes	1	8	8
99	R:R:H242	R:R:Y94	7.62	Yes	Yes	1	6	8
100	R:R:C95	R:R:S137	3.44	Yes	No	0	7	7
101	R:R:C95	R:R:F138	5.59	Yes	No	0	7	3
102	R:R:F235	R:R:S96	5.28	Yes	No	0	9	9
103	R:R:P191	R:R:T97	3.5	Yes	No	0	9	8
104	R:R:F231	R:R:T97	3.89	Yes	No	0	9	8
105	R:R:F235	R:R:T97	7.78	Yes	No	0	9	8
106	R:R:M136	R:R:W98	4.65	No	Yes	0	4	5
107	R:R:S137	R:R:W98	3.71	No	Yes	0	7	5
108	R:R:L187	R:R:W98	5.69	No	Yes	0	6	5
109	R:R:I190	R:R:W98	4.7	No	Yes	6	5	5
110	R:R:P191	R:R:W98	13.51	Yes	Yes	6	9	5
111	R:R:L100	R:R:N265	5.49	No	Yes	1	8	9
112	R:R:D269	R:R:L100	9.5	Yes	No	1	9	8
113	R:R:S104	R:R:T195	7.99	No	No	1	9	7
114	R:R:S104	R:R:Y199	12.72	No	Yes	1	9	8
115	R:R:C198	R:R:I105	4.91	No	No	0	8	6
116	R:R:E106	R:R:Y117	11.22	No	No	0	8	5
117	R:R:R107	R:R:Y199	17.49	No	Yes	1	9	8
118	R:R:R107	R:R:T227	3.88	No	Yes	1	9	7
119	R:R:F273	R:R:R107	8.55	No	No	0	9	9
120	R:R:L109	R:R:Y108	3.52	No	No	0	6	8
121	R:R:A112	R:R:Y108	5.34	No	No	0	7	8
122	R:R:R201	R:R:Y108	9.26	No	No	0	4	8
123	R:R:G110	R:R:Y117	5.79	No	No	0	8	5
124	R:R:F202	R:R:V111	3.93	Yes	No	7	8	8
125	R:R:M206	R:R:V111	4.56	Yes	No	7	8	8
126	R:R:A112	R:R:F113	4.16	No	No	0	7	6
127	R:R:R121	R:R:Y117	13.38	Yes	No	0	7	5
128	R:R:L124	R:R:R122	3.64	No	No	0	3	6
129	R:R:R122	R:R:Y125	11.32	No	No	0	6	4
130	R:R:I128	R:R:L124	8.56	No	No	0	1	3
131	R:R:V135	R:R:W134	3.68	No	No	0	4	9
132	R:R:F138	R:R:W134	14.03	No	No	0	3	9
133	R:R:G139	R:R:T142	3.64	No	No	0	4	4
134	R:R:H140	R:R:L183	6.43	No	No	0	4	5
135	R:R:H140	R:R:L187	10.29	No	No	0	4	6
136	R:R:I145	R:R:Q148	6.86	No	Yes	1	4	5
137	R:R:I145	R:R:Y165	4.84	No	Yes	1	4	4
138	R:R:Q148	R:R:Y149	4.51	Yes	No	0	5	5
139	R:R:Q148	R:R:Y165	6.76	Yes	Yes	1	5	4
140	R:R:F168	R:R:Q172	3.51	No	No	0	4	1
141	R:R:F168	R:R:L173	3.65	No	No	1	4	1
142	R:R:F168	R:R:V176	9.18	No	Yes	1	4	4
143	R:R:N171	R:R:T169	5.85	No	No	0	3	4
144	R:R:D170	R:R:D174	5.32	No	No	0	1	1
145	R:R:N171	R:R:Q172	13.2	No	No	0	3	1
146	R:R:L173	R:R:V176	4.47	No	Yes	1	1	4
147	R:R:L173	R:R:L177	4.15	No	No	0	1	2
148	R:R:R180	R:R:V176	6.54	Yes	Yes	1	5	4
149	R:R:H242	R:R:R180	11.28	Yes	Yes	1	6	5
150	R:R:R180	R:R:R255	15.99	Yes	Yes	1	5	5
151	R:R:L181	R:R:L185	4.15	No	No	0	5	5
152	R:R:L181	R:R:Y246	9.38	No	No	0	5	4
153	R:R:E182	R:R:V186	7.13	No	No	0	4	4
154	R:R:C184	R:R:L243	4.76	No	No	0	6	5
155	R:R:F189	R:R:L185	7.31	No	No	0	4	5
156	R:R:F188	R:R:F189	6.43	Yes	No	0	8	4
157	R:R:F188	R:R:M192	8.71	Yes	No	1	8	6
158	R:R:F188	R:R:F231	4.29	Yes	Yes	1	8	9
159	R:R:F188	R:R:G236	4.52	Yes	No	0	8	5
160	R:R:F188	R:R:N239	16.92	Yes	Yes	1	8	8
161	R:R:I190	R:R:P191	5.08	No	Yes	6	5	9
162	R:R:I196	R:R:M192	4.37	No	No	1	4	6
163	R:R:F231	R:R:M192	3.73	Yes	No	1	9	6
164	R:R:T195	R:R:Y199	3.75	No	Yes	1	7	8
165	R:R:F231	R:R:T195	6.49	Yes	No	1	9	7
166	R:R:I196	R:R:L228	4.28	No	No	1	4	8
167	R:R:I196	R:R:L232	5.71	No	No	1	4	5
168	R:R:F197	R:R:R201	13.9	No	No	0	5	4
169	R:R:T227	R:R:Y199	7.49	Yes	Yes	1	7	8
170	R:R:L228	R:R:Y199	3.52	No	Yes	1	8	8
171	R:R:R201	R:R:W200	5	No	No	0	4	3
172	R:R:W200	R:R:W204	23.43	No	No	0	3	3
173	R:R:F202	R:R:M206	4.98	Yes	Yes	7	8	8
174	R:R:V203	R:R:V221	4.81	No	No	0	5	4
175	R:R:I205	R:R:Q209	4.12	No	No	0	5	5
176	R:R:M206	R:R:R217	8.69	Yes	No	0	8	6
177	R:R:L207	R:R:V221	10.43	No	No	0	4	4
178	R:R:L211	R:R:P210	4.93	No	No	0	3	3
179	R:R:A214	R:R:R217	4.15	No	No	0	3	6
180	R:R:Q215	R:R:R216	9.35	No	No	0	4	5
181	R:R:R216	R:R:R219	5.33	No	No	0	5	7
182	R:R:L223	R:R:R219	3.64	No	No	0	7	7
183	R:R:R219	R:R:S277	9.22	No	No	0	7	8
184	R:R:L272	R:R:V226	5.96	No	No	1	8	5
185	R:R:V226	W:W:?1	7.16	No	Yes	1	5	0
186	R:R:L272	R:R:T227	5.9	No	Yes	1	8	7
187	R:R:L228	R:R:L232	6.92	No	No	1	8	5
188	R:R:C234	R:R:N230	4.72	No	Yes	1	8	7
189	R:R:N230	R:R:N265	5.45	Yes	Yes	1	7	9
190	R:R:L268	R:R:N230	9.61	Yes	Yes	1	7	7
191	R:R:N230	W:W:?1	21.46	Yes	Yes	1	7	0
192	R:R:F231	R:R:L232	3.65	Yes	No	1	9	5
193	R:R:V233	W:W:?1	14.33	No	Yes	0	5	0
194	R:R:C234	R:R:N265	9.45	No	Yes	1	8	9
195	R:R:C234	W:W:?1	3.82	No	Yes	1	8	0
196	R:R:F235	R:R:S262	3.96	Yes	No	1	9	8
197	R:R:F235	R:R:N265	12.08	Yes	Yes	1	9	9
198	R:R:G236	R:R:P237	4.06	No	No	0	5	9
199	R:R:F261	R:R:P237	5.78	No	No	0	7	9
200	R:R:N239	R:R:Y238	4.65	Yes	Yes	1	8	7
201	R:R:H242	R:R:Y238	14.16	Yes	Yes	1	6	7
202	R:R:V259	R:R:Y238	5.05	No	Yes	1	5	7
203	R:R:S262	R:R:Y238	5.09	No	Yes	1	8	7
204	R:R:H242	R:R:N239	5.1	Yes	Yes	1	6	8
205	R:R:V240	R:R:W254	3.68	No	Yes	0	6	4
206	R:R:H242	R:R:S241	4.18	Yes	No	0	6	5
207	R:R:S241	R:R:W254	6.18	No	Yes	0	5	4
208	R:R:R255	R:R:S241	5.27	Yes	No	0	5	5
209	R:R:Q248	R:R:V244	5.73	No	No	0	3	5
210	R:R:P252	R:R:V244	3.53	Yes	No	1	1	5
211	R:R:V244	R:R:W254	8.58	No	Yes	1	5	4
212	R:R:G245	R:R:P252	4.06	No	Yes	0	5	1
213	R:R:K250	R:R:R249	9.9	No	No	0	2	4
214	R:R:P252	R:R:S251	3.56	Yes	No	0	1	4
215	R:R:P252	R:R:W254	12.16	Yes	Yes	1	1	4
216	R:R:P252	R:R:R255	4.32	Yes	Yes	1	1	5
217	R:R:W253	R:R:W254	10.31	No	Yes	0	1	4
218	R:R:F261	W:W:?1	5.86	No	Yes	0	7	0
219	R:R:L264	R:R:L268	6.92	No	Yes	1	5	7
220	R:R:L264	W:W:?1	6.66	No	Yes	1	5	0
221	R:R:D269	R:R:N265	13.46	Yes	Yes	1	9	9
222	R:R:L268	W:W:?1	16.64	Yes	Yes	1	7	0
223	R:R:D269	R:R:F273	7.17	Yes	No	0	9	9
224	R:R:L271	R:R:P270	3.28	No	No	0	7	9
225	R:R:F275	R:R:L271	3.65	No	No	0	7	7
226	R:R:L272	W:W:?1	6.66	No	Yes	1	8	0
227	R:R:F275	R:R:Y274	10.32	No	Yes	0	7	7
228	L:L:?1	R:R:V179	3.2	Yes	No	0	0	4
229	R:R:C95	R:R:L99	3.17	Yes	No	0	7	8
230	R:R:P39	R:R:Q38	3.16	No	No	0	3	5
231	R:R:P210	R:R:Q209	3.16	No	No	0	3	5
232	R:R:A69	R:R:L11	3.15	No	No	0	5	5
233	R:R:A70	R:R:L11	3.15	No	No	0	4	5
234	R:R:A133	R:R:L99	3.15	No	No	0	7	8
235	R:R:C184	R:R:N239	3.15	No	Yes	0	6	8
236	R:R:I46	R:R:V127	3.07	Yes	No	0	7	4
237	R:R:I205	R:R:V111	3.07	No	No	0	5	8
238	R:R:I146	R:R:T142	3.04	No	No	0	4	4
239	R:R:M206	R:R:V221	3.04	Yes	No	0	8	4
240	R:R:L268	R:R:S267	3	Yes	No	0	7	8
241	R:R:L29	R:R:V33	2.98	No	No	0	7	4
242	R:R:L48	R:R:V44	2.98	Yes	No	0	8	7
243	R:R:L131	R:R:V127	2.98	No	No	0	4	4
244	R:R:L29	R:R:T52	2.95	No	No	0	7	8
245	R:R:I16	R:R:I17	2.94	No	No	0	5	7
246	R:R:I36	R:R:I46	2.94	No	Yes	0	5	7
247	R:R:I15	R:R:M12	2.92	No	No	0	6	5
248	R:R:I36	R:R:L49	2.85	No	No	0	5	6
249	R:R:I103	R:R:L47	2.85	No	No	0	9	7
250	R:R:I103	R:R:L48	2.85	No	Yes	0	9	8
251	R:R:I103	R:R:L51	2.85	No	No	0	9	9
252	R:R:I105	R:R:L109	2.85	No	No	0	6	6
253	R:R:C141	R:R:F87	2.79	No	No	0	7	6
254	R:R:P178	R:R:Y246	2.78	No	No	0	2	4
255	R:R:L22	R:R:L26	2.77	Yes	No	2	6	4
256	R:R:L22	R:R:L56	2.77	Yes	No	2	6	7
257	R:R:L22	R:R:L60	2.77	Yes	No	2	6	4
258	R:R:L26	R:R:L56	2.77	No	No	2	4	7
259	R:R:A220	R:R:F202	2.77	No	Yes	0	7	8
260	R:R:A224	R:R:F202	2.77	No	Yes	0	7	8
261	R:R:L150	R:R:N151	2.75	No	No	0	2	5
262	R:R:C82	R:R:Y165	2.69	No	Yes	0	9	4
263	R:R:A224	R:R:Y199	2.67	No	Yes	0	7	8
264	R:R:F73	R:R:S256	2.64	No	No	0	4	4
265	R:R:K118	R:R:R121	2.48	No	Yes	0	4	7
266	R:R:S71	R:R:W75	2.47	No	No	0	4	9
267	R:R:V132	R:R:W98	2.45	No	Yes	0	4	5
268	R:R:I66	R:R:Y14	2.42	No	Yes	0	7	8
269	R:R:I67	R:R:Y76	2.42	No	Yes	0	4	3
270	L:L:?1	R:R:V147	2.13	Yes	No	0	0	4
271	R:R:A24	R:R:G21	1.95	No	No	0	7	8
272	R:R:A101	R:R:P191	1.87	No	Yes	0	8	9
273	R:R:G88	R:R:S91	1.86	No	No	0	5	5
274	R:R:G34	R:R:V33	1.84	No	No	0	4	4
275	R:R:G21	R:R:T20	1.82	No	No	0	8	5
276	R:R:A54	R:R:C95	1.81	No	Yes	0	8	7
277	R:R:G102	R:R:I105	1.76	No	No	0	6	6
278	R:R:C198	R:R:S104	1.72	No	No	0	8	9
279	R:R:A13	R:R:V260	1.7	No	No	0	4	5
280	R:R:A101	R:R:V194	1.7	No	No	0	8	6
281	R:R:I36	R:R:P41	1.69	No	No	0	5	6
282	R:R:I46	R:R:P123	1.69	Yes	Yes	0	7	2
283	R:R:C164	R:R:T163	1.69	No	No	0	9	4
284	R:R:L229	W:W:?1	1.66	No	Yes	0	4	0
285	R:R:L77	R:R:P78	1.64	No	No	0	7	8
286	R:R:V203	R:R:V225	1.6	No	No	0	5	5
287	R:R:A13	R:R:L9	1.58	No	No	0	4	6
288	R:R:P41	R:R:Q40	1.58	No	No	4	6	5
289	R:R:P123	R:R:Q40	1.58	Yes	No	4	2	5
290	R:R:I10	R:R:S256	1.55	No	No	0	5	4
291	R:R:I143	R:R:V147	1.54	No	No	0	7	4
292	R:R:M136	R:R:V186	1.52	No	No	0	4	4
293	R:R:G34	R:R:R37	1.5	No	No	0	4	5
294	R:R:G213	R:R:R217	1.5	No	No	0	4	6
295	R:R:N72	R:R:S7	1.49	No	No	0	3	3
296	R:R:N151	R:R:V147	1.48	No	No	0	5	4
297	R:R:L223	R:R:T227	1.47	No	Yes	0	7	7
298	R:R:N167	R:R:T163	1.46	No	No	0	4	4
299	R:R:D170	R:R:T169	1.45	No	No	0	1	4
300	R:R:F113	R:R:P114	1.44	No	No	0	6	8
301	R:R:P123	R:R:R122	1.44	Yes	No	0	2	6
302	R:R:Q116	R:R:V115	1.43	No	No	0	5	6
303	R:R:L9	R:R:M12	1.41	No	No	0	6	5
304	R:R:A258	R:R:Y238	1.33	No	Yes	0	7	7
305	R:R:E166	R:R:R255	1.16	No	Yes	0	5	5
306	R:R:D4	R:R:W5	1.12	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.30133	15	1	0
2	R:R:K6	4.3775	4	0	5
3	R:R:Y14	5.068	5	0	8
4	R:R:L22	4.266	5	2	6
5	R:R:I46	2.8075	4	0	7
6	R:R:L48	4.5025	4	0	8
7	R:R:L58	5.42	4	1	7
8	R:R:L62	4.34	4	1	8
9	R:R:K65	8.5175	4	1	7
10	R:R:Y76	5.6825	4	5	3
11	R:R:F89	6.02167	6	1	7
12	R:R:Y90	5.93857	7	1	5
13	R:R:I93	5.04	4	1	8
14	R:R:Y94	8.376	5	1	8
15	R:R:C95	3.5025	4	0	7
16	R:R:W98	5.785	6	6	5
17	R:R:R121	7.495	4	0	7
18	R:R:P123	2.6375	4	4	2
19	R:R:Q148	6.4375	4	1	5
20	R:R:Y165	5.94	5	1	4
21	R:R:V176	6.9125	4	1	4
22	R:R:R180	12.365	4	1	5
23	R:R:F188	8.174	5	1	8
24	R:R:P191	5.99	4	6	9
25	R:R:Y199	7.94	6	1	8
26	R:R:F202	3.6125	4	7	8
27	R:R:M206	5.3175	4	7	8
28	R:R:T227	4.685	4	1	7
29	R:R:N230	10.31	4	1	7
30	R:R:F231	4.41	5	1	9
31	R:R:F235	6.824	5	1	9
32	R:R:Y238	6.18444	9	1	7
33	R:R:N239	8.522	5	1	8
34	R:R:H242	8.468	5	1	6
35	R:R:P252	5.526	5	1	1
36	R:R:W254	8.182	5	1	4
37	R:R:R255	5.72333	6	1	5
38	R:R:N265	9.186	5	1	9
39	R:R:L268	9.0425	4	1	7
40	R:R:D269	10.2475	4	1	9
41	R:R:Y274	6.72	4	0	7
42	W:W:?1	9.36111	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y90	10.7197	12.59	Yes	Yes	1	0	5
2	R:R:K65	R:R:Y90	16.19	3.58	Yes	Yes	1	7	5
3	R:R:K65	R:R:Y14	21.2677	9.55	Yes	Yes	0	7	8
4	R:R:I10	R:R:Y14	20.8066	3.63	No	Yes	0	5	8
5	R:R:D4	R:R:K6	11.6224	4.15	No	Yes	0	4	5
6	L:L:?1	R:R:R255	14.1245	3.48	Yes	Yes	1	0	5
7	R:R:S241	R:R:W254	13.1629	6.18	No	Yes	0	5	4
8	R:R:P252	R:R:R255	20.3405	4.32	Yes	Yes	1	1	5
9	R:R:F89	R:R:Y90	10.1653	6.19	Yes	Yes	1	7	5
10	R:R:F89	R:R:L62	21.0911	3.65	Yes	Yes	1	7	8
11	R:R:F18	R:R:L62	11.3968	4.87	No	Yes	0	7	8
12	L:L:?1	R:R:Y238	53.5741	5.87	Yes	Yes	1	0	7
13	R:R:I93	R:R:Y238	33.5181	3.63	Yes	Yes	1	8	7
14	R:R:F235	R:R:I93	71.9963	5.02	Yes	Yes	1	9	8
15	R:R:F235	R:R:N265	100	12.08	Yes	Yes	1	9	9
16	R:R:D269	R:R:N265	84.7226	13.46	Yes	Yes	1	9	9
17	R:R:D269	R:R:F273	78.9334	7.17	Yes	No	0	9	9
18	R:R:F273	R:R:L48	94.3286	6.09	No	Yes	0	9	8
19	R:R:F32	R:R:L48	70.4067	6.09	No	Yes	0	7	8
20	R:R:F32	R:R:Y274	26.9882	7.22	No	Yes	0	7	7
21	R:R:F275	R:R:Y274	21.3658	10.32	No	Yes	0	7	7
22	R:R:F275	R:R:L271	17.5686	3.65	No	No	0	7	7
23	R:R:L271	R:R:P270	15.6552	3.28	No	No	0	7	9
24	R:R:S262	R:R:Y238	32.1199	5.09	No	Yes	1	8	7
25	R:R:F235	R:R:S262	32.2475	3.96	Yes	No	1	9	8
26	R:R:F32	R:R:T52	45.0915	5.19	No	No	0	7	8
27	R:R:L29	R:R:T52	43.3253	2.95	No	No	0	7	8
28	R:R:L29	R:R:L53	36.1625	5.54	No	No	0	7	6
29	R:R:L48	R:R:V44	29.1714	2.98	Yes	No	0	8	7
30	R:R:H45	R:R:V44	13.0108	6.92	No	No	0	7	7
31	R:R:L49	R:R:L53	34.3473	6.92	No	No	0	6	6
32	R:R:I36	R:R:L49	32.5173	2.85	No	No	0	5	6
33	R:R:I36	R:R:I46	17.2742	2.94	No	Yes	0	5	7
34	R:R:I36	R:R:P41	13.4426	1.69	No	No	0	5	6
35	R:R:E106	R:R:V44	14.463	8.56	No	No	0	8	7
36	L:L:?1	R:R:C141	20.1393	3.41	Yes	No	0	0	7
37	R:R:C141	R:R:S91	11.75	3.44	No	No	0	7	5
38	R:R:E68	R:R:K65	16.2145	13.5	No	Yes	0	5	7
39	R:R:E68	R:R:Y76	14.5857	12.35	No	Yes	0	5	3
40	L:L:?1	R:R:Y165	10.9552	10.07	Yes	Yes	1	0	4
41	R:R:Y238	R:R:Y94	10.0525	10.92	Yes	Yes	1	7	8
42	R:R:L187	R:R:Y94	12.5693	4.69	No	Yes	0	6	8
43	R:R:N239	R:R:Y238	24.02	4.65	Yes	Yes	1	8	7
44	R:R:L187	R:R:W98	12.5055	5.69	No	Yes	0	6	5
45	R:R:P191	R:R:W98	15.0076	13.51	Yes	Yes	6	9	5
46	R:R:F235	R:R:T97	24.6431	7.78	Yes	No	0	9	8
47	R:R:P191	R:R:T97	18.0886	3.5	Yes	No	0	9	8
48	R:R:F188	R:R:N239	32.4094	16.92	Yes	Yes	1	8	8
49	R:R:F188	R:R:F231	27.7977	4.29	Yes	Yes	1	8	9
50	R:R:F231	R:R:T195	38.4929	6.49	Yes	No	1	9	7
51	R:R:S104	R:R:T195	12.8146	7.99	No	No	1	9	7
52	R:R:T195	R:R:Y199	25.2171	3.75	No	Yes	1	7	8
53	R:R:C198	R:R:S104	18.0003	1.72	No	No	0	8	9
54	R:R:C198	R:R:I105	16.5383	4.91	No	No	0	8	6
55	R:R:I105	R:R:L109	13.5799	2.85	No	No	0	6	6
56	R:R:L109	R:R:Y108	12.2798	3.52	No	No	0	6	8
57	R:R:A224	R:R:Y199	23.5539	2.67	No	Yes	0	7	8
58	R:R:A224	R:R:F202	22.2833	2.77	No	Yes	0	7	8
59	R:R:F202	R:R:M206	11.9511	4.98	Yes	Yes	7	8	8
60	R:R:P123	R:R:R122	15.4786	1.44	Yes	No	0	2	6
61	L:L:?1	R:R:Q172	11.2986	6.67	Yes	No	0	0	1
62	R:R:N230	R:R:N265	14.6495	5.45	Yes	Yes	1	7	9
63	R:R:C234	R:R:N265	10.3861	9.45	No	Yes	1	8	9
64	R:R:V260	R:R:Y14	10.1114	5.05	No	Yes	0	5	8
65	R:R:R255	R:R:Y90	13.1629	4.12	Yes	Yes	1	5	5
66	R:R:F89	R:R:I93	41.9762	3.77	Yes	Yes	1	7	8
67	R:R:Y238	R:R:Y90	19.4623	4.96	Yes	Yes	1	7	5
68	R:R:R107	R:R:Y199	14.9291	17.49	No	Yes	1	9	8
69	R:R:F273	R:R:R107	20.5563	8.55	No	No	0	9	9
70	R:R:H242	R:R:S241	13.2905	4.18	Yes	No	0	6	5
71	R:R:F231	R:R:T97	16.1605	3.89	Yes	No	0	9	8
72	R:R:L62	R:R:Y14	14.2913	4.69	Yes	Yes	0	8	8
73	R:R:F89	R:R:K65	19.9431	7.44	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y90	12.59	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:C141	3.41	1	Yes	No	0	7	0	1
L:L:?1	R:R:V144	12.8	1	Yes	No	0	5	0	1
L:L:?1	R:R:I145	7.15	1	Yes	No	0	4	0	1
L:L:?1	R:R:Q148	7.62	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y165	10.07	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Q172	6.67	1	Yes	No	0	1	0	1
L:L:?1	R:R:V175	7.46	1	Yes	No	0	3	0	1
L:L:?1	R:R:V176	7.46	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R180	15.65	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L183	3.96	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y238	5.87	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R255	3.48	1	Yes	Yes	0	5	0	1
R:R:F89	R:R:K65	7.44	1	Yes	Yes	7	7	2	2
R:R:K65	R:R:Y90	3.58	1	Yes	Yes	7	5	2	1
R:R:A83	R:R:Y165	5.34	0	No	Yes	7	4	2	1
R:R:S86	R:R:Y90	3.82	0	No	Yes	6	5	2	1
R:R:F89	R:R:Y90	6.19	1	Yes	Yes	7	5	2	1
R:R:F89	R:R:I93	3.77	1	Yes	Yes	7	8	2	2
R:R:F89	R:R:V259	6.55	1	Yes	No	7	5	2	2
R:R:Y238	R:R:Y90	4.96	1	Yes	Yes	7	5	1	1
R:R:R255	R:R:Y90	4.12	1	Yes	Yes	5	5	1	1
R:R:V259	R:R:Y90	6.31	1	No	Yes	5	5	2	1
R:R:C141	R:R:S91	3.44	0	No	No	7	5	1	2
R:R:I93	R:R:Y238	3.63	1	Yes	Yes	8	7	2	1
R:R:I93	R:R:S262	7.74	1	Yes	No	8	8	2	2
R:R:L183	R:R:Y94	5.86	0	No	Yes	5	8	1	2
R:R:Y238	R:R:Y94	10.92	1	Yes	Yes	7	8	1	2
R:R:N239	R:R:Y94	12.79	1	Yes	Yes	8	8	2	2
R:R:H242	R:R:Y94	7.62	1	Yes	Yes	6	8	2	2
R:R:H140	R:R:L183	6.43	0	No	No	4	5	2	1
R:R:I145	R:R:Q148	6.86	1	No	Yes	4	5	1	1
R:R:I145	R:R:Y165	4.84	1	No	Yes	4	4	1	1
R:R:Q148	R:R:Y149	4.51	1	Yes	No	5	5	1	2
R:R:Q148	R:R:Y165	6.76	1	Yes	Yes	5	4	1	1
R:R:F168	R:R:Q172	3.51	1	No	No	4	1	2	1
R:R:F168	R:R:L173	3.65	1	No	No	4	1	2	2
R:R:F168	R:R:V176	9.18	1	No	Yes	4	4	2	1
R:R:N171	R:R:Q172	13.2	0	No	No	3	1	2	1
R:R:L173	R:R:V176	4.47	1	No	Yes	1	4	2	1
R:R:R180	R:R:V176	6.54	1	Yes	Yes	5	4	1	1
R:R:H242	R:R:R180	11.28	1	Yes	Yes	6	5	2	1
R:R:R180	R:R:R255	15.99	1	Yes	Yes	5	5	1	1
R:R:N239	R:R:Y238	4.65	1	Yes	Yes	8	7	2	1
R:R:H242	R:R:Y238	14.16	1	Yes	Yes	6	7	2	1
R:R:V259	R:R:Y238	5.05	1	No	Yes	5	7	2	1
R:R:S262	R:R:Y238	5.09	1	No	Yes	8	7	2	1
R:R:H242	R:R:N239	5.1	1	Yes	Yes	6	8	2	2
R:R:H242	R:R:S241	4.18	1	Yes	No	6	5	2	2
R:R:R255	R:R:S241	5.27	1	Yes	No	5	5	1	2
R:R:P252	R:R:R255	4.32	1	Yes	Yes	1	5	2	1
L:L:?1	R:R:V179	3.2	1	Yes	No	0	4	0	1
R:R:C141	R:R:F87	2.79	0	No	No	7	6	1	2
R:R:C82	R:R:Y165	2.69	0	No	Yes	9	4	2	1
L:L:?1	R:R:V147	2.13	1	Yes	No	0	4	0	1
R:R:I143	R:R:V147	1.54	0	No	No	7	4	2	1
R:R:N151	R:R:V147	1.48	0	No	No	5	4	2	1
R:R:A258	R:R:Y238	1.33	0	No	Yes	7	7	2	1
R:R:E166	R:R:R255	1.16	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I17	R:R:L264	4.28	0	No	No	7	5	2	1
R:R:L272	R:R:V226	5.96	1	No	No	8	5	1	1
R:R:V226	W:W:?1	7.16	1	No	Yes	5	0	1	0
R:R:L272	R:R:T227	5.9	1	No	Yes	8	7	1	2
R:R:C234	R:R:N230	4.72	1	No	Yes	8	7	1	1
R:R:N230	R:R:N265	5.45	1	Yes	Yes	7	9	1	2
R:R:L268	R:R:N230	9.61	1	Yes	Yes	7	7	1	1
R:R:N230	W:W:?1	21.46	1	Yes	Yes	7	0	1	0
R:R:V233	W:W:?1	14.33	0	No	Yes	5	0	1	0
R:R:C234	R:R:N265	9.45	1	No	Yes	8	9	1	2
R:R:C234	W:W:?1	3.82	1	No	Yes	8	0	1	0
R:R:F261	R:R:P237	5.78	0	No	No	7	9	1	2
R:R:F261	W:W:?1	5.86	0	No	Yes	7	0	1	0
R:R:L264	R:R:L268	6.92	1	No	Yes	5	7	1	1
R:R:L264	W:W:?1	6.66	1	No	Yes	5	0	1	0
R:R:L268	W:W:?1	16.64	1	Yes	Yes	7	0	1	0
R:R:L272	W:W:?1	6.66	1	No	Yes	8	0	1	0
R:R:L268	R:R:S267	3	1	Yes	No	7	8	1	2
R:R:L229	W:W:?1	1.66	0	No	Yes	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9CLW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	252
Number of Links	306
Number of Hubs	42
Number of Links mediated by Hubs	168
Number of Communities	7
Number of Nodes involved in Communities	66
Number of Links involved in Communities	100

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	52547
Length Of Smallest Path	3
Average Path Length	11.6693
Length of Longest Path	26
Minimum Path Strength	1.495
Average Path Strength	6.28648
Maximum Path Strength	17.895
Minimum Path Correlation	0.7
Average Path Correlation	0.915296
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	49.6398
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.6425
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • binding • lipid binding • cellular response to stimulus • positive regulation of response to biotic stimulus • immune response-regulating cell surface receptor signaling pathway • regulation of cellular process • response to stimulus • pattern recognition receptor signaling pathway • response to biotic stimulus • cell communication • immune response-activating signaling pathway • positive regulation of immune response • regulation of immune system process • signal transduction • positive regulation of immune system process • innate immune response-activating signaling pathway • regulation of biological process • immune response • response to other organism • immune response-activating cell surface receptor signaling pathway • regulation of innate immune response • response to external stimulus • regulation of response to stimulus • defense response to other organism • positive regulation of defense response • activation of innate immune response • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of response to external stimulus • signaling • positive regulation of biological process • innate immune response activating cell surface receptor signaling pathway • positive regulation of response to stimulus • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of response to stress • response to stress • innate immune response • response to external biotic stimulus • cell surface pattern recognition receptor signaling pathway • positive regulation of innate immune response • cell surface receptor signaling pathway • defense response • biological regulation • defense response to symbiont • immune system process • cellular process • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • localization • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • regulation of cell communication • hormone transport • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • macromolecule localization • insulin secretion • multicellular organismal process • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of biosynthetic process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of interleukin-8 production • regulation of chemokine production • chemokine production • positive regulation of chemokine production • cell chemotaxis • leukocyte chemotaxis involved in inflammatory response • chemotaxis • leukocyte migration involved in inflammatory response • leukocyte migration • cellular response to chemical stimulus • taxis • response to chemical • cell migration • inflammatory response • cell motility • leukocyte chemotaxis • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • mucosal immune response • organ or tissue specific immune response • lipid storage • nutrient storage • positive regulation of acute inflammatory response • positive regulation of inflammatory response • regulation of acute inflammatory response to non-antigenic stimulus • acute inflammatory response • acute inflammatory response to non-antigenic stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response to non-antigenic stimulus • regulation of acute inflammatory response • response to lipid • response to fatty acid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to fatty acid • cellular response to lipid • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • regulation of immune effector process • positive regulation of immune effector process • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune effector process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • cell projection • protein binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9UJ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	9UJ
Name	(2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid
Synonyms	TUG-1375
Identifier
Formula	C22 H19 Cl N2 O4 S
Molecular Weight	442.915
SMILES
PubChem	138319694
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	17


Code	_W_
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>9CLW_nogp_Chain_R D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N F R W Y L P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T T C Y E N F T D N Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q P L G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F S S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	Gi1/β1/γ2	3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8Y6W	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	Gi1/β1/γ2	3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6W (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6Y	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	GLPG0974	-	-	3.36	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	9CLW	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CLW (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729	Gi1/β1/γ2	3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729		3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	Gi1/β1/γ2	3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6

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