psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D4	R:R:N72	9.42	No	No	0	4	3
2	R:R:N72	R:R:S7	8.94	No	No	0	3	3
3	R:R:F73	R:R:S7	3.96	No	No	0	4	3
4	R:R:I10	R:R:Y14	4.84	No	Yes	0	5	8
5	R:R:L62	R:R:Y14	8.21	No	Yes	0	8	8
6	R:R:K65	R:R:Y14	11.94	No	Yes	0	7	8
7	R:R:I66	R:R:Y14	4.84	No	Yes	0	7	8
8	R:R:V259	R:R:Y14	3.79	No	Yes	0	5	8
9	R:R:V260	R:R:Y14	6.31	No	Yes	0	5	8
10	R:R:I15	R:R:I66	5.89	No	No	0	6	7
11	R:R:I17	R:R:L264	4.28	No	No	0	7	5
12	R:R:F18	R:R:L22	3.65	No	No	0	7	6
13	R:R:F18	R:R:L62	3.65	No	No	0	7	8
14	R:R:F18	R:R:P63	4.33	No	No	0	7	9
15	R:R:S267	R:R:T20	4.8	No	No	0	8	5
16	R:R:G21	R:R:L59	3.42	No	No	0	8	6
17	R:R:G21	R:R:S267	3.71	No	No	0	8	8
18	R:R:A24	R:R:P270	3.74	No	No	0	7	9
19	R:R:N25	R:R:T52	5.85	Yes	No	0	9	8
20	R:R:D55	R:R:N25	6.73	Yes	Yes	0	9	9
21	R:R:L56	R:R:N25	6.87	No	Yes	0	7	9
22	R:R:L59	R:R:N25	5.49	No	Yes	0	6	9
23	R:R:N25	R:R:P270	8.15	Yes	No	0	9	9
24	R:R:L26	R:R:L56	4.15	No	No	0	4	7
25	R:R:A28	R:R:Y274	4	No	No	0	8	7
26	R:R:L29	R:R:T52	4.42	No	No	0	7	8
27	R:R:L29	R:R:L53	4.15	No	No	0	7	6
28	R:R:A31	R:R:Y274	6.67	No	No	0	7	7
29	R:R:F32	R:R:L48	12.18	Yes	No	0	7	8
30	R:R:F32	R:R:T52	5.19	Yes	No	0	7	8
31	R:R:Q38	R:R:R35	8.18	No	No	0	5	5
32	R:R:H45	R:R:R35	18.05	No	No	0	7	5
33	R:R:P123	R:R:P41	3.9	No	No	0	2	6
34	R:R:A42	R:R:H45	4.39	No	No	0	7	7
35	R:R:E106	R:R:P43	4.72	No	No	0	8	7
36	R:R:P43	R:R:R121	4.32	No	No	0	7	7
37	R:R:E106	R:R:V44	4.28	No	No	0	8	7
38	R:R:G126	R:R:I46	5.29	No	No	0	8	7
39	R:R:I46	R:R:V127	4.61	No	No	0	7	4
40	R:R:I103	R:R:L47	4.28	Yes	No	0	9	7
41	R:R:F273	R:R:L48	4.87	Yes	No	0	9	8
42	R:R:L99	R:R:S50	6.01	No	No	0	8	9
43	R:R:A130	R:R:S50	3.42	No	No	0	7	9
44	R:R:D55	R:R:L51	8.14	Yes	Yes	1	9	9
45	R:R:L100	R:R:L51	5.54	No	Yes	1	8	9
46	R:R:D269	R:R:L51	5.43	Yes	Yes	1	9	9
47	R:R:F273	R:R:L51	3.65	Yes	Yes	1	9	9
48	R:R:A54	R:R:C95	3.61	No	Yes	0	8	7
49	R:R:A266	R:R:D55	6.18	No	Yes	0	8	9
50	R:R:D269	R:R:D55	6.65	Yes	Yes	1	9	9
51	R:R:F89	R:R:L58	8.53	Yes	No	0	7	7
52	R:R:L58	R:R:S92	7.51	No	No	0	7	8
53	R:R:A266	R:R:L59	4.73	No	No	0	8	6
54	R:R:F64	R:R:V81	3.93	No	No	0	6	6
55	R:R:F64	R:R:T85	14.27	No	No	0	6	5
56	R:R:E68	R:R:K65	8.1	No	No	0	5	7
57	R:R:F89	R:R:K65	8.69	Yes	No	0	7	7
58	R:R:E68	R:R:W75	7.63	No	Yes	2	5	9
59	R:R:C164	R:R:E68	6.08	Yes	No	2	9	5
60	R:R:S71	R:R:Y76	5.09	No	No	0	4	3
61	R:R:F73	R:R:S256	5.28	No	No	0	4	4
62	R:R:R74	R:R:Y76	13.38	No	No	0	4	3
63	R:R:I162	R:R:R74	11.27	No	No	0	4	4
64	R:R:L77	R:R:W75	10.25	No	Yes	0	7	9
65	R:R:V81	R:R:W75	3.68	No	Yes	0	6	9
66	R:R:C82	R:R:W75	7.84	No	Yes	2	9	9
67	R:R:C164	R:R:W75	7.84	Yes	Yes	2	9	9
68	R:R:P78	R:R:V81	5.3	No	No	0	8	6
69	R:R:C164	R:R:C82	7.28	Yes	No	2	9	9
70	R:R:C164	R:R:S86	3.44	Yes	No	0	9	6
71	R:R:S86	R:R:Y165	5.09	No	Yes	0	6	4
72	R:R:F87	R:R:G88	4.52	Yes	No	0	6	5
73	R:R:F87	R:R:S91	7.93	Yes	No	1	6	5
74	R:R:C141	R:R:F87	4.19	No	Yes	1	7	6
75	R:R:F87	R:R:T142	3.89	Yes	No	0	6	4
76	R:R:F87	R:R:I145	6.28	Yes	No	0	6	4
77	R:R:F89	R:R:V259	6.55	Yes	No	0	7	5
78	R:R:F89	R:R:S263	5.28	Yes	No	0	7	6
79	R:R:Y238	R:R:Y90	5.96	Yes	No	1	7	5
80	R:R:R255	R:R:Y90	4.12	Yes	No	1	5	5
81	L:L:?1	R:R:Y90	14.27	Yes	No	1	0	5
82	R:R:F138	R:R:S91	11.89	Yes	No	1	3	5
83	R:R:C141	R:R:S91	5.16	No	No	1	7	5
84	R:R:I93	R:R:Y238	3.63	No	Yes	1	8	7
85	R:R:I93	R:R:S262	4.64	No	No	1	8	8
86	R:R:L187	R:R:Y94	9.38	No	Yes	0	6	8
87	R:R:Y238	R:R:Y94	11.91	Yes	Yes	1	7	8
88	R:R:N239	R:R:Y94	5.81	No	Yes	1	8	8
89	R:R:H242	R:R:Y94	4.36	Yes	Yes	1	6	8
90	R:R:C95	R:R:S137	5.16	Yes	No	1	7	7
91	R:R:C95	R:R:F138	5.59	Yes	Yes	1	7	3
92	R:R:P191	R:R:T97	3.5	Yes	No	0	9	8
93	R:R:F235	R:R:T97	9.08	No	No	0	9	8
94	R:R:M136	R:R:W98	15.12	No	No	0	4	5
95	R:R:L187	R:R:W98	5.69	No	No	0	6	5
96	R:R:P191	R:R:W98	20.27	Yes	No	0	9	5
97	R:R:F231	R:R:L100	3.65	Yes	No	1	9	8
98	R:R:D269	R:R:L100	4.07	Yes	No	1	9	8
99	R:R:I103	R:R:R107	6.26	Yes	Yes	1	9	9
100	R:R:F273	R:R:I103	3.77	Yes	Yes	1	9	9
101	R:R:S104	R:R:T195	9.59	No	No	0	9	7
102	R:R:C198	R:R:S104	5.16	No	No	0	8	9
103	R:R:S104	R:R:Y199	5.09	No	Yes	0	9	8
104	R:R:E106	R:R:Y117	5.61	No	No	0	8	5
105	R:R:R107	R:R:Y199	9.26	Yes	Yes	1	9	8
106	R:R:R107	R:R:T227	3.88	Yes	No	1	9	7
107	R:R:F273	R:R:R107	5.34	Yes	Yes	1	9	9
108	R:R:L109	R:R:Y108	3.52	No	Yes	0	6	8
109	R:R:A112	R:R:Y108	9.34	No	Yes	4	7	8
110	R:R:F113	R:R:Y108	4.13	Yes	Yes	4	6	8
111	R:R:C198	R:R:Y108	4.03	No	Yes	0	8	8
112	R:R:R201	R:R:Y108	6.17	No	Yes	0	4	8
113	R:R:G110	R:R:Y117	7.24	No	No	0	8	5
114	R:R:F202	R:R:V111	5.24	Yes	No	0	8	8
115	R:R:A112	R:R:F113	5.55	No	Yes	4	7	6
116	R:R:Q116	R:R:V115	5.73	No	No	0	5	6
117	R:R:R121	R:R:Y117	8.23	No	No	0	7	5
118	R:R:L124	R:R:R122	6.07	No	No	0	3	6
119	R:R:R122	R:R:Y125	7.2	No	No	0	6	4
120	R:R:I128	R:R:L124	4.28	No	No	0	1	3
121	R:R:V135	R:R:W134	3.68	No	No	0	4	9
122	R:R:F138	R:R:W134	17.04	Yes	No	0	3	9
123	R:R:F138	R:R:S137	5.28	Yes	No	1	3	7
124	R:R:G139	R:R:T142	3.64	No	No	0	4	4
125	R:R:E182	R:R:H140	8.62	No	No	0	4	4
126	R:R:H140	R:R:L183	5.14	No	No	0	4	5
127	R:R:H140	R:R:L187	7.71	No	No	0	4	6
128	L:L:?1	R:R:C141	3.41	Yes	No	1	0	7
129	L:L:?1	R:R:V144	9.6	Yes	No	0	0	5
130	R:R:Q148	R:R:Y165	10.15	No	Yes	1	5	4
131	L:L:?1	R:R:Q148	4.76	Yes	No	1	0	5
132	R:R:N167	R:R:T163	4.39	No	No	0	4	4
133	R:R:F168	R:R:Y165	5.16	Yes	Yes	1	4	4
134	L:L:?1	R:R:Y165	7.55	Yes	Yes	1	0	4
135	R:R:E166	R:R:R255	6.98	No	Yes	0	5	5
136	R:R:F168	R:R:Q172	4.68	Yes	No	0	4	1
137	R:R:F168	R:R:V176	13.11	Yes	Yes	1	4	4
138	R:R:F168	R:R:R180	4.28	Yes	Yes	1	4	5
139	L:L:?1	R:R:F168	6.97	Yes	Yes	1	0	4
140	R:R:Q172	R:R:T169	15.59	No	No	0	1	4
141	R:R:D170	R:R:N171	12.12	No	No	0	1	3
142	R:R:L173	R:R:L177	8.3	No	No	0	1	2
143	L:L:?1	R:R:V175	7.46	Yes	No	0	0	3
144	R:R:R180	R:R:V176	7.85	Yes	Yes	1	5	4
145	L:L:?1	R:R:V176	12.8	Yes	Yes	1	0	4
146	R:R:H242	R:R:R180	10.16	Yes	Yes	1	6	5
147	R:R:R180	R:R:S251	5.27	Yes	No	0	5	4
148	R:R:R180	R:R:R255	18.13	Yes	Yes	1	5	5
149	L:L:?1	R:R:R180	11.3	Yes	Yes	1	0	5
150	R:R:L181	R:R:Y246	7.03	No	No	0	5	4
151	R:R:E182	R:R:V186	7.13	No	No	0	4	4
152	L:L:?1	R:R:L183	3.96	Yes	No	0	0	5
153	R:R:C184	R:R:F189	4.19	No	No	0	6	4
154	R:R:C184	R:R:H242	4.42	No	Yes	0	6	6
155	R:R:C184	R:R:L243	7.94	No	No	0	6	5
156	R:R:F188	R:R:F189	4.29	Yes	No	1	8	4
157	R:R:F188	R:R:M192	7.46	Yes	Yes	1	8	6
158	R:R:F188	R:R:F231	6.43	Yes	Yes	1	8	9
159	R:R:F188	R:R:N239	19.33	Yes	No	1	8	8
160	R:R:F189	R:R:M192	4.98	No	Yes	1	4	6
161	R:R:I196	R:R:M192	5.83	No	Yes	0	4	6
162	R:R:F231	R:R:M192	3.73	Yes	Yes	1	9	6
163	R:R:F231	R:R:T195	6.49	Yes	No	0	9	7
164	R:R:F197	R:R:R201	7.48	No	No	0	5	4
165	R:R:T227	R:R:Y199	8.74	No	Yes	1	7	8
166	R:R:L228	R:R:Y199	4.69	No	Yes	0	8	8
167	R:R:F202	R:R:M206	6.22	Yes	No	0	8	8
168	R:R:V203	R:R:V221	4.81	No	No	0	5	4
169	R:R:I205	R:R:W204	3.52	No	No	0	5	3
170	R:R:L207	R:R:R217	3.64	No	No	0	4	6
171	R:R:Q209	R:R:V212	11.46	No	No	0	5	3
172	R:R:R217	R:R:V212	6.54	No	No	0	6	3
173	R:R:R219	R:R:V280	3.92	No	No	0	7	7
174	R:R:L223	R:R:S276	6.01	No	No	0	7	7
175	R:R:L272	R:R:V226	4.47	No	No	0	8	5
176	R:R:V226	W:W:?1	7.16	No	Yes	0	5	0
177	R:R:L272	R:R:T227	5.9	No	No	0	8	7
178	R:R:L229	W:W:?1	8.32	No	Yes	0	4	0
179	R:R:N230	R:R:N265	5.45	No	Yes	0	7	9
180	R:R:N230	W:W:?1	23.11	No	Yes	0	7	0
181	R:R:F231	R:R:L232	3.65	Yes	No	0	9	5
182	R:R:V233	W:W:?1	10.74	No	Yes	0	5	0
183	R:R:C234	R:R:N265	11.02	No	Yes	0	8	9
184	R:R:F235	R:R:S262	3.96	No	No	0	9	8
185	R:R:F235	R:R:N265	7.25	No	Yes	0	9	9
186	R:R:G236	R:R:P237	4.06	No	No	0	5	9
187	R:R:H242	R:R:Y238	9.8	Yes	Yes	1	6	7
188	R:R:S262	R:R:Y238	3.82	No	Yes	1	8	7
189	L:L:?1	R:R:Y238	5.87	Yes	Yes	1	0	7
190	R:R:H242	R:R:N239	3.83	Yes	No	1	6	8
191	R:R:P252	R:R:S241	3.56	Yes	No	1	1	5
192	R:R:S241	R:R:W254	3.71	No	Yes	1	5	4
193	R:R:R255	R:R:S241	5.27	Yes	No	1	5	5
194	R:R:Q248	R:R:V244	4.3	No	No	0	3	5
195	R:R:V244	R:R:W254	3.68	No	Yes	0	5	4
196	R:R:G245	R:R:P252	4.06	No	Yes	0	5	1
197	R:R:P252	R:R:S251	3.56	Yes	No	0	1	4
198	R:R:P252	R:R:W254	4.05	Yes	Yes	1	1	4
199	R:R:P252	R:R:R255	5.76	Yes	Yes	1	1	5
200	R:R:W253	R:R:W254	9.37	No	Yes	0	1	4
201	L:L:?1	R:R:R255	5.22	Yes	Yes	1	0	5
202	R:R:L264	R:R:L268	6.92	No	No	3	5	7
203	R:R:L264	W:W:?1	4.99	No	Yes	3	5	0
204	R:R:D269	R:R:N265	16.16	Yes	Yes	0	9	9
205	R:R:L268	W:W:?1	16.64	No	Yes	3	7	0
206	R:R:D269	R:R:F273	8.36	Yes	Yes	1	9	9
207	R:R:F275	R:R:L271	7.31	Yes	No	0	7	7
208	R:R:F275	R:R:Y274	6.19	Yes	No	0	7	7
209	R:R:I190	R:R:P191	3.39	No	Yes	0	5	9
210	R:R:L22	R:R:P23	3.28	No	No	0	6	4
211	R:R:C198	R:R:I105	3.27	No	No	0	8	6
212	R:R:V144	R:R:V179	3.21	No	No	0	5	4
213	L:L:?1	R:R:V147	3.2	Yes	No	0	0	4
214	R:R:C95	R:R:L99	3.17	Yes	No	0	7	8
215	R:R:P39	R:R:Q38	3.16	No	No	0	3	5
216	R:R:P210	R:R:Q209	3.16	No	No	0	3	5
217	R:R:A133	R:R:L99	3.15	No	No	0	7	8
218	R:R:M12	R:R:S8	3.07	No	No	0	5	5
219	R:R:I103	R:R:V44	3.07	Yes	No	0	9	7
220	R:R:I105	R:R:V194	3.07	No	No	0	6	6
221	R:R:I205	R:R:V111	3.07	No	No	0	5	8
222	R:R:L51	R:R:S96	3	Yes	No	0	9	9
223	R:R:L57	R:R:S92	3	No	No	0	7	8
224	R:R:L29	R:R:V33	2.98	No	No	0	7	4
225	R:R:L119	R:R:V115	2.98	No	No	0	4	6
226	R:R:L177	R:R:V176	2.98	No	Yes	0	2	4
227	R:R:L207	R:R:V221	2.98	No	No	0	4	4
228	R:R:L229	R:R:V225	2.98	No	No	0	4	5
229	R:R:I10	R:R:I257	2.94	No	No	0	5	5
230	R:R:I36	R:R:I46	2.94	No	No	0	5	7
231	R:R:F261	W:W:?1	2.93	No	Yes	0	7	0
232	R:R:N171	R:R:T169	2.92	No	No	0	3	4
233	R:R:I15	R:R:L19	2.85	No	No	0	6	4
234	R:R:A24	R:R:F275	2.77	No	Yes	0	7	7
235	R:R:A28	R:R:F32	2.77	No	Yes	0	8	7
236	R:R:A42	R:R:R121	2.77	No	No	0	7	7
237	R:R:H45	R:R:V44	2.77	No	No	0	7	7
238	R:R:L181	R:R:L185	2.77	No	No	0	5	5
239	R:R:L181	R:R:L243	2.77	No	No	0	5	5
240	R:R:A220	R:R:F202	2.77	No	Yes	0	7	8
241	R:R:A224	R:R:F202	2.77	No	Yes	0	7	8
242	R:R:A83	R:R:Y149	2.67	No	No	0	7	5
243	R:R:A224	R:R:Y199	2.67	No	Yes	0	7	8
244	R:R:A258	R:R:W254	2.59	No	Yes	0	7	4
245	R:R:F32	R:R:L49	2.44	Yes	No	0	7	6
246	R:R:F64	R:R:L61	2.44	No	No	0	6	7
247	R:R:L223	R:R:R219	2.43	No	No	0	7	7
248	R:R:F113	R:R:Q116	2.34	Yes	No	0	6	5
249	R:R:K6	R:R:W253	2.32	No	No	0	5	1
250	R:R:G126	R:R:P43	2.03	No	No	0	8	7
251	R:R:A129	R:R:G126	1.95	No	No	0	5	8
252	R:R:A101	R:R:P191	1.87	No	Yes	0	8	9
253	R:R:A258	R:R:P237	1.87	No	No	0	7	9
254	R:R:G34	R:R:V33	1.84	No	No	0	4	4
255	R:R:G213	R:R:V212	1.84	No	No	0	4	3
256	R:R:P78	R:R:V80	1.77	No	No	0	8	4
257	R:R:G102	R:R:I105	1.76	No	No	0	6	6
258	R:R:A13	R:R:V260	1.7	No	No	0	4	5
259	R:R:A224	R:R:V203	1.7	No	No	0	7	5
260	R:R:L177	R:R:P178	1.64	No	No	0	2	2
261	R:R:A69	R:R:I10	1.62	No	No	0	5	5
262	R:R:A83	R:R:I145	1.62	No	No	0	7	4
263	R:R:V240	R:R:V244	1.6	No	No	0	6	5
264	R:R:A69	R:R:L11	1.58	No	No	0	5	5
265	R:R:A70	R:R:L11	1.58	No	No	0	4	5
266	R:R:P39	R:R:Q40	1.58	No	No	0	3	5
267	R:R:I67	R:R:S71	1.55	No	No	0	4	4
268	R:R:I257	R:R:S256	1.55	No	No	0	5	4
269	R:R:I128	R:R:V132	1.54	No	No	0	1	4
270	R:R:M136	R:R:V132	1.52	No	No	0	4	4
271	R:R:I146	R:R:T142	1.52	No	No	0	4	4
272	R:R:I162	R:R:T163	1.52	No	No	0	4	4
273	R:R:L119	R:R:S120	1.5	No	No	0	4	4
274	R:R:L131	R:R:V127	1.49	No	No	0	4	4
275	R:R:P41	R:R:R35	1.44	No	No	0	6	5
276	R:R:F113	R:R:P114	1.44	Yes	No	0	6	8
277	R:R:P123	R:R:R122	1.44	No	No	0	2	6
278	R:R:I67	R:R:L77	1.43	No	No	0	4	7
279	R:R:L11	R:R:M12	1.41	No	No	0	5	5
280	R:R:L22	R:R:L60	1.38	No	No	0	6	4
281	R:R:L223	R:R:L272	1.38	No	No	0	7	8
282	R:R:D174	R:R:L173	1.36	No	No	0	1	1
283	R:R:K250	R:R:Q248	1.36	No	No	0	2	3
284	R:R:L211	R:R:Q209	1.33	No	No	0	3	5
285	R:R:F275	R:R:L27	1.22	Yes	No	0	7	6
286	R:R:Q215	R:R:R219	1.17	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y14	6.655	6	0	8
2	R:R:N25	6.618	5	0	9
3	R:R:F32	5.645	4	0	7
4	R:R:L51	5.152	5	1	9
5	R:R:D55	6.925	4	1	9
6	R:R:W75	7.448	5	2	9
7	R:R:F87	5.362	5	1	6
8	R:R:F89	7.2625	4	0	7
9	R:R:Y94	7.865	4	1	8
10	R:R:C95	4.3825	4	1	7
11	R:R:I103	4.345	4	1	9
12	R:R:R107	6.185	4	1	9
13	R:R:Y108	5.438	5	4	8
14	R:R:F113	3.365	4	4	6
15	R:R:F138	9.95	4	1	3
16	R:R:C164	6.16	4	2	9
17	R:R:Y165	6.9875	4	1	4
18	R:R:F168	6.84	5	1	4
19	R:R:V176	9.185	4	1	4
20	R:R:R180	9.49833	6	1	5
21	R:R:F188	9.3775	4	1	8
22	R:R:P191	7.2575	4	0	9
23	R:R:M192	5.5	4	1	6
24	R:R:Y199	6.09	5	1	8
25	R:R:F202	4.25	4	0	8
26	R:R:F231	4.79	5	1	9
27	R:R:Y238	6.83167	6	1	7
28	R:R:H242	6.514	5	1	6
29	R:R:P252	4.198	5	1	1
30	R:R:W254	4.68	5	1	4
31	R:R:R255	7.58	6	1	5
32	R:R:N265	9.97	4	0	9
33	R:R:D269	8.134	5	1	9
34	R:R:F273	5.198	5	1	9
35	R:R:F275	4.3725	4	0	7
36	L:L:?1	7.41308	13	1	0
37	W:W:?1	10.5557	7	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I257	R:R:S256	11.1651	1.55	No	No	0	5	4
2	R:R:I10	R:R:I257	13.1325	2.94	No	No	0	5	5
3	R:R:I10	R:R:Y14	26.1906	4.84	No	Yes	0	5	8
4	R:R:L62	R:R:Y14	13.405	8.21	No	Yes	0	8	8
5	R:R:K65	R:R:Y14	52.183	11.94	No	Yes	0	7	8
6	R:R:E68	R:R:K65	65.806	8.1	No	No	0	5	7
7	R:R:C164	R:R:E68	65.142	6.08	Yes	No	2	9	5
8	R:R:C164	R:R:S86	98.4489	3.44	Yes	No	0	9	6
9	R:R:S86	R:R:Y165	100	5.09	No	Yes	0	6	4
10	L:L:?1	R:R:Y165	85.3561	7.55	Yes	Yes	1	0	4
11	L:L:?1	R:R:Y238	99.1922	5.87	Yes	Yes	1	0	7
12	R:R:S262	R:R:Y238	68.7646	3.82	No	Yes	1	8	7
13	R:R:F235	R:R:S262	68.9033	3.96	No	No	0	9	8
14	R:R:F235	R:R:N265	71.4257	7.25	No	Yes	0	9	9
15	R:R:N230	R:R:N265	17.315	5.45	No	Yes	0	7	9
16	R:R:N230	W:W:?1	16.0712	23.11	No	Yes	0	7	0
17	R:R:F18	R:R:L62	11.1948	3.65	No	No	0	7	8
18	R:R:D269	R:R:N265	60.6968	16.16	Yes	Yes	0	9	9
19	R:R:D269	R:R:D55	30.284	6.65	Yes	Yes	1	9	9
20	R:R:D55	R:R:N25	28.0192	6.73	Yes	Yes	0	9	9
21	R:R:G21	R:R:L59	12.6468	3.42	No	No	0	8	6
22	R:R:A266	R:R:D55	10.3623	6.18	No	Yes	0	8	9
23	R:R:F32	R:R:L48	10.6546	12.18	Yes	No	0	7	8
24	R:R:F273	R:R:L48	12.0521	4.87	Yes	No	0	9	8
25	R:R:D269	R:R:F273	45.4433	8.36	Yes	Yes	1	9	9
26	R:R:F273	R:R:I103	31.6022	3.77	Yes	Yes	1	9	9
27	R:R:I103	R:R:V44	35.5023	3.07	Yes	No	0	9	7
28	R:R:H45	R:R:V44	15.4269	2.77	No	No	0	7	7
29	R:R:H45	R:R:R35	11.3732	18.05	No	No	0	7	5
30	L:L:?1	R:R:L183	11.5714	3.96	Yes	No	0	0	5
31	R:R:H140	R:R:L183	10.2136	5.14	No	No	0	4	5
32	R:R:H140	R:R:L187	12.3049	7.71	No	No	0	4	6
33	R:R:L187	R:R:W98	21.5918	5.69	No	No	0	6	5
34	R:R:M136	R:R:W98	15.0701	15.12	No	No	0	4	5
35	R:R:M136	R:R:V132	12.9987	1.52	No	No	0	4	4
36	R:R:I128	R:R:V132	10.9817	1.54	No	No	0	1	4
37	R:R:Y238	R:R:Y94	28.5941	11.91	Yes	Yes	1	7	8
38	R:R:L187	R:R:Y94	18.8166	9.38	No	Yes	0	6	8
39	R:R:E106	R:R:V44	20.001	4.28	No	No	0	8	7
40	R:R:E106	R:R:P43	13.6231	4.72	No	No	0	8	7
41	R:R:G126	R:R:P43	10.7587	2.03	No	No	0	8	7
42	L:L:?1	R:R:C141	36.4042	3.41	Yes	No	1	0	7
43	R:R:C141	R:R:S91	20.4371	5.16	No	No	1	7	5
44	R:R:F138	R:R:S91	19.0247	11.89	Yes	No	1	3	5
45	R:R:C95	R:R:F138	11.5021	5.59	Yes	Yes	1	7	3
46	R:R:F168	R:R:Y165	16.091	5.16	Yes	Yes	1	4	4
47	R:R:F168	R:R:R180	16.1505	4.28	Yes	Yes	1	4	5
48	R:R:H242	R:R:R180	50.954	10.16	Yes	Yes	1	6	5
49	R:R:H242	R:R:N239	56.6728	3.83	Yes	No	1	6	8
50	R:R:F188	R:R:N239	77.8383	19.33	Yes	No	1	8	8
51	R:R:F188	R:R:F231	77.9176	6.43	Yes	Yes	1	8	9
52	R:R:F231	R:R:L100	20.8534	3.65	Yes	No	1	9	8
53	L:L:?1	R:R:R180	21.0665	11.3	Yes	Yes	1	0	5
54	R:R:H242	R:R:Y238	22.1121	9.8	Yes	Yes	1	6	7
55	R:R:N239	R:R:Y94	22.2756	5.81	No	Yes	1	8	8
56	R:R:D269	R:R:L100	10.6943	4.07	Yes	No	1	9	8
57	R:R:F89	R:R:K65	12.8103	8.69	Yes	No	0	7	7
58	R:R:V81	R:R:W75	13.0334	3.68	No	Yes	0	6	9
59	R:R:L77	R:R:W75	17.5628	10.25	No	Yes	0	7	9
60	R:R:I67	R:R:L77	15.3972	1.43	No	No	0	4	7
61	R:R:I67	R:R:S71	13.2217	1.55	No	No	0	4	4
62	R:R:S71	R:R:Y76	11.0362	5.09	No	No	0	4	3
63	R:R:C141	R:R:F87	14.4308	4.19	No	Yes	1	7	6
64	L:L:?1	R:R:R255	24.466	5.22	Yes	Yes	1	0	5
65	R:R:F273	R:R:R107	20.8435	5.34	Yes	Yes	1	9	9
66	R:R:F231	R:R:T195	69.3543	6.49	Yes	No	0	9	7
67	R:R:S104	R:R:T195	67.491	9.59	No	No	0	9	7
68	R:R:C198	R:R:S104	40.0615	5.16	No	No	0	8	9
69	R:R:S104	R:R:Y199	43.7038	5.09	No	Yes	0	9	8
70	R:R:R107	R:R:Y199	22.1567	9.26	Yes	Yes	1	9	8
71	R:R:C198	R:R:Y108	29.5158	4.03	No	Yes	0	8	8
72	R:R:F113	R:R:Y108	16.0811	4.13	Yes	Yes	4	6	8
73	R:R:A224	R:R:Y199	45.3689	2.67	No	Yes	0	7	8
74	R:R:A224	R:R:F202	16.9087	2.77	No	Yes	0	7	8
75	R:R:F113	R:R:Q116	10.9768	2.34	Yes	No	0	6	5
76	R:R:C184	R:R:H242	11.3435	4.42	No	Yes	0	6	6
77	R:R:C184	R:R:L243	12.1859	7.94	No	No	0	6	5
78	R:R:C184	R:R:F189	11.8886	4.19	No	No	0	6	4
79	R:R:A224	R:R:V203	26.1708	1.7	No	No	0	7	5
80	R:R:V203	R:R:V221	23.3064	4.81	No	No	0	5	4
81	R:R:L207	R:R:V221	20.4222	2.98	No	No	0	4	4
82	R:R:L207	R:R:R217	17.5331	3.64	No	No	0	4	6
83	R:R:R217	R:R:V212	14.639	6.54	No	No	0	6	3
84	R:R:R255	R:R:S241	20.6105	5.27	Yes	No	1	5	5
85	R:R:S241	R:R:W254	18.7522	3.71	No	Yes	1	5	4
86	R:R:A258	R:R:W254	12.5675	2.59	No	Yes	0	7	4
87	R:R:P252	R:R:R255	22.3847	5.76	Yes	Yes	1	1	5
88	R:R:P252	R:R:W254	22.5928	4.05	Yes	Yes	1	1	4
89	R:R:V244	R:R:W254	16.9434	3.68	No	Yes	0	5	4
90	R:R:A69	R:R:I10	11.1948	1.62	No	No	0	5	5
91	R:R:C164	R:R:W75	29.724	7.84	Yes	Yes	2	9	9
92	R:R:Y238	R:R:Y90	12.9095	5.96	Yes	No	1	7	5
93	R:R:R255	R:R:Y90	11.9778	4.12	Yes	No	1	5	5
94	R:R:F273	R:R:L51	10.1492	3.65	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S86	R:R:Y165	5.09	0	No	Yes	6	4	2	1
R:R:F87	R:R:S91	7.93	1	Yes	No	6	5	2	2
R:R:C141	R:R:F87	4.19	1	No	Yes	7	6	1	2
R:R:Y238	R:R:Y90	5.96	1	Yes	No	7	5	1	1
R:R:R255	R:R:Y90	4.12	1	Yes	No	5	5	1	1
L:L:?1	R:R:Y90	14.27	1	Yes	No	0	5	0	1
R:R:C141	R:R:S91	5.16	1	No	No	7	5	1	2
R:R:I93	R:R:Y238	3.63	1	No	Yes	8	7	2	1
R:R:I93	R:R:S262	4.64	1	No	No	8	8	2	2
R:R:Y238	R:R:Y94	11.91	1	Yes	Yes	7	8	1	2
R:R:H242	R:R:Y94	4.36	1	Yes	Yes	6	8	2	2
R:R:H140	R:R:L183	5.14	0	No	No	4	5	2	1
L:L:?1	R:R:C141	3.41	1	Yes	No	0	7	0	1
L:L:?1	R:R:V144	9.6	1	Yes	No	0	5	0	1
R:R:Q148	R:R:Y165	10.15	1	No	Yes	5	4	1	1
L:L:?1	R:R:Q148	4.76	1	Yes	No	0	5	0	1
R:R:F168	R:R:Y165	5.16	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:Y165	7.55	1	Yes	Yes	0	4	0	1
R:R:E166	R:R:R255	6.98	0	No	Yes	5	5	2	1
R:R:F168	R:R:Q172	4.68	1	Yes	No	4	1	1	2
R:R:F168	R:R:V176	13.11	1	Yes	Yes	4	4	1	1
R:R:F168	R:R:R180	4.28	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:F168	6.97	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:V175	7.46	1	Yes	No	0	3	0	1
R:R:R180	R:R:V176	7.85	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:V176	12.8	1	Yes	Yes	0	4	0	1
R:R:H242	R:R:R180	10.16	1	Yes	Yes	6	5	2	1
R:R:R180	R:R:S251	5.27	1	Yes	No	5	4	1	2
R:R:R180	R:R:R255	18.13	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:R180	11.3	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L183	3.96	1	Yes	No	0	5	0	1
R:R:H242	R:R:Y238	9.8	1	Yes	Yes	6	7	2	1
R:R:S262	R:R:Y238	3.82	1	No	Yes	8	7	2	1
L:L:?1	R:R:Y238	5.87	1	Yes	Yes	0	7	0	1
R:R:P252	R:R:S241	3.56	1	Yes	No	1	5	2	2
R:R:R255	R:R:S241	5.27	1	Yes	No	5	5	1	2
R:R:P252	R:R:S251	3.56	1	Yes	No	1	4	2	2
R:R:P252	R:R:R255	5.76	1	Yes	Yes	1	5	2	1
L:L:?1	R:R:R255	5.22	1	Yes	Yes	0	5	0	1
R:R:V144	R:R:V179	3.21	0	No	No	5	4	1	2
L:L:?1	R:R:V147	3.2	1	Yes	No	0	4	0	1
R:R:L177	R:R:V176	2.98	0	No	Yes	2	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I17	R:R:L264	4.28	0	No	No	7	5	2	1
R:R:L272	R:R:V226	4.47	0	No	No	8	5	2	1
R:R:V226	W:W:?1	7.16	0	No	Yes	5	0	1	0
R:R:L229	W:W:?1	8.32	0	No	Yes	4	0	1	0
R:R:N230	R:R:N265	5.45	0	No	Yes	7	9	1	2
R:R:N230	W:W:?1	23.11	0	No	Yes	7	0	1	0
R:R:V233	W:W:?1	10.74	0	No	Yes	5	0	1	0
R:R:L264	R:R:L268	6.92	3	No	No	5	7	1	1
R:R:L264	W:W:?1	4.99	3	No	Yes	5	0	1	0
R:R:L268	W:W:?1	16.64	3	No	Yes	7	0	1	0
R:R:L229	R:R:V225	2.98	0	No	No	4	5	1	2
R:R:F261	W:W:?1	2.93	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Y6W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.41
Number of Linked Nodes	246
Number of Links	286
Number of Hubs	37
Number of Links mediated by Hubs	147
Number of Communities	4
Number of Nodes involved in Communities	46
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	57210
Length Of Smallest Path	3
Average Path Length	13.1632
Length of Longest Path	30
Minimum Path Strength	1.49
Average Path Strength	6.35398
Maximum Path Strength	19.875
Minimum Path Correlation	0.7
Average Path Correlation	0.920844
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	46.8617
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.5789
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of response to biotic stimulus • immune response-regulating cell surface receptor signaling pathway • regulation of cellular process • response to stimulus • pattern recognition receptor signaling pathway • response to biotic stimulus • cell communication • immune response-activating signaling pathway • positive regulation of immune response • regulation of immune system process • signal transduction • positive regulation of immune system process • innate immune response-activating signaling pathway • regulation of biological process • immune response • response to other organism • immune response-activating cell surface receptor signaling pathway • regulation of innate immune response • response to external stimulus • regulation of response to stimulus • defense response to other organism • positive regulation of defense response • activation of innate immune response • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of response to external stimulus • signaling • positive regulation of biological process • innate immune response activating cell surface receptor signaling pathway • positive regulation of response to stimulus • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of response to stress • response to stress • innate immune response • response to external biotic stimulus • cell surface pattern recognition receptor signaling pathway • positive regulation of innate immune response • cell surface receptor signaling pathway • defense response • biological regulation • defense response to symbiont • immune system process • cellular process • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • localization • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • regulation of cell communication • hormone transport • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • macromolecule localization • insulin secretion • multicellular organismal process • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of biosynthetic process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of interleukin-8 production • regulation of chemokine production • chemokine production • positive regulation of chemokine production • cell chemotaxis • leukocyte chemotaxis involved in inflammatory response • chemotaxis • leukocyte migration involved in inflammatory response • leukocyte migration • cellular response to chemical stimulus • taxis • response to chemical • cell migration • inflammatory response • cell motility • leukocyte chemotaxis • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • mucosal immune response • organ or tissue specific immune response • lipid storage • nutrient storage • positive regulation of acute inflammatory response • positive regulation of inflammatory response • regulation of acute inflammatory response to non-antigenic stimulus • acute inflammatory response • acute inflammatory response to non-antigenic stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response to non-antigenic stimulus • regulation of acute inflammatory response • response to lipid • response to fatty acid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to fatty acid • cellular response to lipid • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • regulation of immune effector process • positive regulation of immune effector process • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune effector process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9UJ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	9UJ
Name	(2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid
Synonyms	TUG-1375
Identifier
Formula	C22 H19 Cl N2 O4 S
Molecular Weight	442.915
SMILES
PubChem	138319694
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	17


Code	_W_
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>8Y6W_nogp_Chain_R P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N F R W Y L P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N I T C Y E N F T D N Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q P L V G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F S S S V V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	Gi1/β1/γ2	3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8Y6W	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	Gi1/β1/γ2	3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6W (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6Y	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	GLPG0974	-	-	3.36	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	9CLW	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CLW (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729	Gi1/β1/γ2	3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729		3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	Gi1/β1/γ2	3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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