psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L9	R:R:S8	3	No	No	0	6	5
2	R:R:I10	R:R:I257	2.94	No	No	0	5	5
3	R:R:I10	R:R:V260	3.07	No	No	0	5	5
4	R:R:I15	R:R:L11	4.28	Yes	No	0	6	5
5	R:R:A70	R:R:L11	6.3	No	No	0	4	5
6	R:R:I15	R:R:M12	2.92	Yes	No	0	6	5
7	R:R:K65	R:R:Y14	11.94	Yes	No	0	7	8
8	R:R:V260	R:R:Y14	5.05	No	No	0	5	8
9	R:R:I15	R:R:L19	2.85	Yes	No	0	6	4
10	R:R:I17	R:R:L62	2.85	Yes	Yes	1	7	8
11	R:R:I17	R:R:S263	7.74	Yes	No	1	7	6
12	R:R:I17	R:R:L264	2.85	Yes	No	0	7	5
13	R:R:I17	R:R:S267	6.19	Yes	No	0	7	8
14	R:R:F18	R:R:L22	8.53	Yes	Yes	0	7	6
15	R:R:F18	R:R:L62	6.09	Yes	Yes	0	7	8
16	R:R:F18	R:R:P63	5.78	Yes	No	0	7	9
17	R:R:F18	R:R:I66	3.77	Yes	No	0	7	7
18	R:R:G21	R:R:L59	3.42	No	Yes	0	8	6
19	R:R:L22	R:R:P23	3.28	Yes	No	0	6	4
20	R:R:L22	R:R:L26	2.77	Yes	No	0	6	4
21	R:R:L22	R:R:L59	4.15	Yes	Yes	0	6	6
22	R:R:A24	R:R:P270	3.74	No	No	0	7	9
23	R:R:D55	R:R:N25	4.04	Yes	Yes	0	9	9
24	R:R:L56	R:R:N25	4.12	No	Yes	0	7	9
25	R:R:L59	R:R:N25	5.49	Yes	Yes	0	6	9
26	R:R:N25	R:R:P270	4.89	Yes	No	0	9	9
27	R:R:L27	R:R:Y274	4.69	No	No	0	6	7
28	R:R:A28	R:R:F32	2.77	No	Yes	0	8	7
29	R:R:L29	R:R:V33	2.98	No	No	0	7	4
30	R:R:L29	R:R:T52	2.95	No	No	0	7	8
31	R:R:L29	R:R:L53	4.15	No	No	0	7	6
32	R:R:F32	R:R:L48	14.61	Yes	Yes	2	7	8
33	R:R:F32	R:R:T52	3.89	Yes	No	0	7	8
34	R:R:F273	R:R:F32	8.57	No	Yes	2	9	7
35	R:R:H45	R:R:V35	8.3	No	No	0	7	5
36	R:R:L49	R:R:V36	7.45	No	No	0	6	5
37	R:R:P39	R:R:Q38	3.16	No	No	0	3	5
38	R:R:P123	R:R:P41	5.84	No	No	0	2	6
39	R:R:A42	R:R:H45	4.39	No	No	0	7	7
40	R:R:P43	R:R:R121	4.32	No	No	0	7	7
41	R:R:H45	R:R:V44	2.77	No	No	0	7	7
42	R:R:L48	R:R:V44	2.98	Yes	No	0	8	7
43	R:R:E106	R:R:V44	2.85	No	No	0	8	7
44	R:R:G126	R:R:I46	5.29	No	No	0	8	7
45	R:R:I103	R:R:L47	2.85	No	No	0	9	7
46	R:R:E106	R:R:L47	3.98	No	No	0	8	7
47	R:R:I103	R:R:L48	2.85	No	Yes	0	9	8
48	R:R:F273	R:R:L48	6.09	No	Yes	2	9	8
49	R:R:L49	R:R:T52	2.95	No	No	0	6	8
50	R:R:L49	R:R:L53	4.15	No	No	0	6	6
51	R:R:L99	R:R:S50	6.01	No	No	0	8	9
52	R:R:A130	R:R:S50	3.42	No	No	0	7	9
53	R:R:D55	R:R:L51	6.79	Yes	Yes	1	9	9
54	R:R:L51	R:R:S96	3	Yes	No	1	9	9
55	R:R:L100	R:R:L51	4.15	Yes	Yes	1	8	9
56	R:R:D269	R:R:L51	6.79	Yes	Yes	1	9	9
57	R:R:D55	R:R:S96	4.42	Yes	No	1	9	9
58	R:R:D55	R:R:N265	2.69	Yes	Yes	1	9	9
59	R:R:A266	R:R:D55	6.18	No	Yes	0	8	9
60	R:R:D269	R:R:D55	3.99	Yes	Yes	1	9	9
61	R:R:L56	R:R:L60	2.77	No	No	0	7	4
62	R:R:L57	R:R:L61	2.77	No	No	0	7	7
63	R:R:F89	R:R:L58	10.96	Yes	Yes	0	7	7
64	R:R:L58	R:R:S92	4.5	Yes	No	0	7	8
65	R:R:I93	R:R:L58	2.85	No	Yes	0	8	7
66	R:R:L58	R:R:S263	3	Yes	No	0	7	6
67	R:R:L59	R:R:L62	2.77	Yes	Yes	0	6	8
68	R:R:F89	R:R:L61	3.65	Yes	No	0	7	7
69	R:R:F89	R:R:L62	4.87	Yes	Yes	1	7	8
70	R:R:L62	R:R:S263	4.5	Yes	No	1	8	6
71	R:R:F64	R:R:V81	3.93	No	No	0	6	6
72	R:R:F64	R:R:T85	15.56	No	No	0	6	5
73	R:R:F89	R:R:K65	13.65	Yes	Yes	1	7	7
74	R:R:K65	R:R:Y90	4.78	Yes	Yes	1	7	5
75	R:R:S71	R:R:W75	4.94	No	No	0	4	9
76	R:R:N72	R:R:W75	6.78	No	No	0	3	9
77	R:R:R74	R:R:W75	3	No	No	0	4	9
78	R:R:C164	R:R:L77	3.17	Yes	No	0	9	7
79	R:R:P78	R:R:V81	12.37	No	No	0	8	6
80	R:R:C82	R:R:K79	4.85	No	No	3	9	2
81	R:R:C164	R:R:K79	9.7	Yes	No	3	9	2
82	R:R:C164	R:R:C82	7.28	Yes	No	3	9	9
83	R:R:A83	R:R:N160	4.69	No	Yes	0	7	5
84	R:R:F87	R:R:G88	4.52	Yes	No	0	6	5
85	R:R:F138	R:R:F87	6.43	No	Yes	0	3	6
86	R:R:C141	R:R:F87	2.79	No	Yes	0	7	6
87	R:R:F89	R:R:Y90	3.09	Yes	Yes	1	7	5
88	R:R:E166	R:R:Y90	3.37	Yes	Yes	1	5	5
89	R:R:Y238	R:R:Y90	9.93	Yes	Yes	1	7	5
90	R:R:V259	R:R:Y90	8.83	No	Yes	0	5	5
91	L:L:?1	R:R:Y90	7.55	Yes	Yes	1	0	5
92	R:R:S137	R:R:S91	3.26	No	No	0	7	5
93	R:R:F138	R:R:S91	11.89	No	No	0	3	5
94	R:R:C141	R:R:S91	6.89	No	No	0	7	5
95	R:R:I93	R:R:Y238	3.63	No	Yes	1	8	7
96	R:R:I93	R:R:S262	6.19	No	No	1	8	8
97	R:R:L183	R:R:Y94	5.86	No	Yes	1	5	8
98	R:R:L187	R:R:Y94	8.21	Yes	Yes	1	6	8
99	R:R:Y238	R:R:Y94	5.96	Yes	Yes	1	7	8
100	R:R:N239	R:R:Y94	5.81	Yes	Yes	1	8	8
101	R:R:H242	R:R:Y94	3.27	Yes	Yes	0	6	8
102	R:R:C95	R:R:L99	3.17	Yes	No	0	7	8
103	R:R:C95	R:R:W134	9.14	Yes	No	0	7	9
104	R:R:C95	R:R:S137	5.16	Yes	No	0	7	7
105	R:R:P191	R:R:T97	3.5	Yes	No	0	9	8
106	R:R:F231	R:R:T97	5.19	Yes	No	1	9	8
107	R:R:F235	R:R:T97	11.67	Yes	No	1	9	8
108	R:R:M136	R:R:W98	5.82	No	Yes	1	4	5
109	R:R:L187	R:R:W98	5.69	Yes	Yes	1	6	5
110	R:R:P191	R:R:W98	12.16	Yes	Yes	0	9	5
111	R:R:A133	R:R:L99	3.15	No	No	0	7	8
112	R:R:F231	R:R:L100	3.65	Yes	Yes	1	9	8
113	R:R:L100	R:R:N265	4.12	Yes	Yes	1	8	9
114	R:R:D269	R:R:L100	4.07	Yes	Yes	1	9	8
115	R:R:S104	R:R:T195	6.4	No	No	0	9	7
116	R:R:C198	R:R:S104	5.16	No	No	0	8	9
117	R:R:S104	R:R:Y199	13.99	No	Yes	0	9	8
118	R:R:I105	R:R:V194	3.07	No	No	0	6	6
119	R:R:E106	R:R:Y117	8.98	No	No	0	8	5
120	R:R:R107	R:R:Y199	8.23	No	Yes	4	9	8
121	R:R:R107	R:R:T227	3.88	No	No	4	9	7
122	R:R:A112	R:R:Y108	5.34	No	No	0	7	8
123	R:R:C198	R:R:Y108	6.72	No	No	0	8	8
124	R:R:R201	R:R:Y108	6.17	No	No	0	4	8
125	R:R:G110	R:R:Y117	2.9	No	No	0	8	5
126	R:R:F202	R:R:V111	7.87	No	No	0	8	8
127	R:R:I205	R:R:V111	4.61	No	No	0	5	8
128	R:R:A112	R:R:F113	6.93	No	Yes	0	7	6
129	R:R:F113	R:R:Q116	10.54	Yes	No	0	6	5
130	R:R:R122	R:R:Y125	4.12	No	No	0	6	4
131	R:R:I128	R:R:L124	4.28	No	No	0	1	3
132	R:R:L131	R:R:V127	2.98	No	No	0	4	4
133	R:R:F138	R:R:W134	5.01	No	No	0	3	9
134	R:R:H140	R:R:M136	5.25	Yes	No	1	4	4
135	R:R:L187	R:R:M136	2.83	Yes	No	1	6	4
136	R:R:E182	R:R:H140	9.85	No	Yes	0	4	4
137	R:R:H140	R:R:L183	3.86	Yes	No	1	4	5
138	R:R:H140	R:R:L187	10.29	Yes	Yes	1	4	6
139	L:L:?1	R:R:V144	11.73	Yes	No	0	0	5
140	R:R:I145	R:R:N160	8.5	No	Yes	0	4	5
141	L:L:?1	R:R:I145	4.09	Yes	No	0	0	4
142	R:R:I146	R:R:N158	5.66	No	No	0	4	2
143	R:R:N151	R:R:V147	2.96	No	No	0	5	4
144	L:L:?1	R:R:V147	5.33	Yes	No	0	0	4
145	R:R:N160	R:R:Q148	18.49	Yes	Yes	1	5	5
146	R:R:I162	R:R:Q148	9.61	Yes	Yes	1	4	5
147	R:R:Q148	R:R:T163	5.67	Yes	Yes	1	5	4
148	L:L:?1	R:R:Q148	22.87	Yes	Yes	1	0	5
149	R:R:T152	R:R:Y149	4.99	No	Yes	0	3	5
150	R:R:E154	R:R:Y149	14.59	No	Yes	5	1	5
151	R:R:R157	R:R:Y149	4.12	No	Yes	5	3	5
152	R:R:E161	R:R:Y149	10.1	No	Yes	0	3	5
153	R:R:I162	R:R:T152	4.56	Yes	No	0	4	3
154	R:R:E154	R:R:R157	3.49	No	No	5	1	3
155	R:R:Q155	R:R:V156	2.87	No	No	0	3	1
156	R:R:R157	R:R:V156	5.23	No	No	0	3	1
157	R:R:I162	R:R:N160	4.25	Yes	Yes	1	4	5
158	R:R:I162	R:R:T163	3.04	Yes	Yes	1	4	4
159	R:R:E166	R:R:T163	4.23	Yes	Yes	1	5	4
160	L:L:?1	R:R:T163	6.33	Yes	Yes	1	0	4
161	R:R:N167	R:R:Y165	4.65	No	No	0	4	4
162	R:R:E166	R:R:R255	5.82	Yes	Yes	1	5	5
163	L:L:?1	R:R:E166	2.85	Yes	Yes	1	0	5
164	R:R:F168	R:R:Q172	10.54	No	No	1	4	1
165	L:L:?1	R:R:F168	3.49	Yes	No	1	0	4
166	L:L:?1	R:R:Q172	4.76	Yes	No	1	0	1
167	L:L:?1	R:R:V175	6.4	Yes	No	0	0	3
168	R:R:L177	R:R:V176	2.98	No	No	0	2	4
169	R:R:R180	R:R:V176	6.54	Yes	No	1	5	4
170	L:L:?1	R:R:V176	8.53	Yes	No	1	0	4
171	R:R:F246	R:R:L177	3.65	No	No	0	4	2
172	L:L:?1	R:R:V179	5.33	Yes	No	0	0	4
173	R:R:H242	R:R:R180	14.67	Yes	Yes	0	6	5
174	R:R:R180	R:R:S251	5.27	Yes	No	0	5	4
175	R:R:R180	R:R:R255	14.93	Yes	Yes	1	5	5
176	L:L:?1	R:R:R180	7.83	Yes	Yes	1	0	5
177	R:R:L181	R:R:L185	4.15	No	No	0	5	5
178	R:R:L181	R:R:L243	2.77	No	No	0	5	5
179	R:R:F246	R:R:L181	8.53	No	No	0	4	5
180	R:R:E182	R:R:V186	5.7	No	No	0	4	4
181	R:R:L183	R:R:L187	4.15	No	Yes	1	5	6
182	R:R:C184	R:R:F189	4.19	Yes	No	0	6	4
183	R:R:C184	R:R:N239	3.15	Yes	Yes	0	6	8
184	R:R:C184	R:R:H242	4.42	Yes	Yes	0	6	6
185	R:R:C184	R:R:L243	4.76	Yes	No	0	6	5
186	R:R:L187	R:R:V186	2.98	Yes	No	0	6	4
187	R:R:I190	R:R:V186	3.07	No	No	0	5	4
188	R:R:F188	R:R:F231	6.43	No	Yes	0	8	9
189	R:R:F188	R:R:N239	18.12	No	Yes	0	8	8
190	R:R:I190	R:R:P191	3.39	No	Yes	0	5	9
191	R:R:I196	R:R:M192	2.92	No	No	6	4	6
192	R:R:L232	R:R:M192	2.83	No	No	6	5	6
193	R:R:I196	R:R:L232	4.28	No	No	6	4	5
194	R:R:F197	R:R:R201	5.34	No	No	0	5	4
195	R:R:A224	R:R:Y199	2.67	No	Yes	0	7	8
196	R:R:T227	R:R:Y199	9.99	No	Yes	4	7	8
197	R:R:L228	R:R:Y199	7.03	No	Yes	0	8	8
198	R:R:W200	R:R:W204	14.06	No	No	0	3	3
199	R:R:F202	R:R:M206	6.22	No	No	0	8	8
200	R:R:A224	R:R:F202	2.77	No	No	0	7	8
201	R:R:L207	R:R:V203	2.98	No	No	7	4	5
202	R:R:V203	R:R:V221	4.81	No	No	7	5	4
203	R:R:M206	R:R:V212	3.04	No	Yes	0	8	3
204	R:R:A220	R:R:M206	3.22	No	No	0	7	8
205	R:R:L207	R:R:V221	2.98	No	No	7	4	4
206	R:R:P210	R:R:Q209	4.74	No	No	0	3	5
207	R:R:Q209	R:R:V212	4.3	No	Yes	0	5	3
208	R:R:H211	R:R:P210	3.05	No	No	0	3	3
209	R:R:R217	R:R:V212	10.46	No	Yes	0	6	3
210	R:R:Q215	R:R:R218	3.5	No	No	0	4	5
211	R:R:L223	R:R:R219	3.64	No	No	0	7	7
212	R:R:L272	R:R:V226	2.98	No	No	0	8	5
213	R:R:L272	R:R:T227	4.42	No	No	0	8	7
214	R:R:L228	R:R:L232	4.15	No	No	0	8	5
215	R:R:C234	R:R:N230	4.72	No	No	0	8	7
216	R:R:L268	R:R:N230	6.87	No	No	0	7	7
217	R:R:L272	R:R:N230	2.75	No	No	0	8	7
218	R:R:F231	R:R:F235	3.22	Yes	Yes	1	9	9
219	R:R:C234	R:R:N265	3.15	No	Yes	0	8	9
220	R:R:F235	R:R:S262	3.96	Yes	No	1	9	8
221	R:R:F235	R:R:N265	13.29	Yes	Yes	1	9	9
222	R:R:G236	R:R:P237	4.06	No	No	0	5	9
223	R:R:F261	R:R:P237	4.33	No	No	0	7	9
224	R:R:N239	R:R:Y238	4.65	Yes	Yes	1	8	7
225	R:R:R255	R:R:Y238	5.14	Yes	Yes	1	5	7
226	R:R:S262	R:R:Y238	3.82	No	Yes	1	8	7
227	L:L:?1	R:R:Y238	4.2	Yes	Yes	1	0	7
228	R:R:H242	R:R:S241	2.79	Yes	Yes	0	6	5
229	R:R:P252	R:R:S241	5.34	Yes	Yes	1	1	5
230	R:R:S241	R:R:W254	4.94	Yes	Yes	1	5	4
231	R:R:R255	R:R:S241	3.95	Yes	Yes	1	5	5
232	R:R:Q248	R:R:V244	5.73	No	No	0	3	5
233	R:R:F246	R:R:R249	5.34	No	No	0	4	4
234	R:R:K250	R:R:Q248	9.49	No	No	0	2	3
235	R:R:P252	R:R:S251	3.56	Yes	No	0	1	4
236	R:R:P252	R:R:W254	4.05	Yes	Yes	1	1	4
237	R:R:P252	R:R:R255	5.76	Yes	Yes	1	1	5
238	R:R:W253	R:R:W254	5.62	No	Yes	0	1	4
239	L:L:?1	R:R:R255	4.35	Yes	Yes	1	0	5
240	R:R:I257	R:R:S256	3.1	No	No	0	5	4
241	R:R:F261	R:R:I257	3.77	No	No	0	7	5
242	R:R:D269	R:R:N265	13.46	Yes	Yes	1	9	9
243	R:R:F284	R:R:V280	6.55	No	No	0	6	7
244	R:R:R281	R:R:R282	4.26	No	No	0	8	4
245	R:R:F284	R:R:R281	3.21	No	No	0	6	8
246	R:R:Q289	R:R:R286	11.68	No	No	0	4	4
247	R:R:F87	R:R:T142	2.59	Yes	No	0	6	4
248	R:R:I103	R:R:R107	2.51	No	No	0	9	9
249	R:R:V132	R:R:W98	2.45	No	Yes	0	4	5
250	R:R:V244	R:R:W254	2.45	No	Yes	0	5	4
251	R:R:F113	R:R:L109	2.44	Yes	No	0	6	6
252	R:R:F168	R:R:L173	2.44	No	No	0	4	1
253	R:R:F275	R:R:L223	2.44	No	No	0	7	7
254	R:R:L27	R:R:R281	2.43	No	No	0	6	8
255	R:R:T208	R:R:W204	2.43	No	No	0	4	3
256	R:R:G126	R:R:P43	2.03	No	No	0	8	7
257	R:R:G245	R:R:P252	2.03	No	Yes	0	5	1
258	R:R:A129	R:R:G126	1.95	No	No	0	5	8
259	R:R:A42	R:R:P43	1.87	No	No	0	7	7
260	R:R:A101	R:R:P191	1.87	No	Yes	0	8	9
261	R:R:A258	R:R:P237	1.87	No	No	0	7	9
262	R:R:G34	R:R:V33	1.84	No	No	0	4	4
263	R:R:G213	R:R:V212	1.84	No	Yes	0	3	3
264	R:R:G287	R:R:V290	1.84	No	No	0	3	3
265	R:R:G21	R:R:T20	1.82	No	No	0	8	5
266	R:R:G86	R:R:T85	1.82	No	No	0	6	5
267	R:R:G139	R:R:T142	1.82	No	No	0	4	4
268	R:R:A54	R:R:C95	1.81	No	Yes	0	8	7
269	R:R:G102	R:R:I105	1.76	No	No	0	6	6
270	L:L:?1	R:R:F87	1.74	Yes	Yes	0	0	6
271	R:R:A69	R:R:S7	1.71	No	No	0	5	3
272	R:R:G102	R:R:L47	1.71	No	No	0	6	7
273	R:R:C198	R:R:V194	1.71	No	No	0	8	6
274	R:R:G285	R:R:L288	1.71	No	No	0	2	4
275	R:R:A13	R:R:V260	1.7	No	No	0	4	5
276	R:R:G159	R:R:N160	1.7	No	Yes	0	3	5
277	R:R:A224	R:R:V203	1.7	No	No	0	7	5
278	R:R:I46	R:R:P123	1.69	No	No	0	7	2
279	R:R:G34	R:R:Q38	1.64	No	No	0	4	5
280	R:R:L77	R:R:P78	1.64	No	No	0	7	8
281	R:R:L177	R:R:P178	1.64	No	No	0	2	2
282	R:R:A69	R:R:I10	1.62	No	No	0	5	5
283	R:R:S278	R:R:V279	1.62	No	No	0	4	5
284	R:R:V240	R:R:V244	1.6	No	No	0	6	5
285	R:R:V279	R:R:V280	1.6	No	No	0	5	7
286	R:R:P41	R:R:Q40	1.58	No	No	0	6	5
287	R:R:I128	R:R:V132	1.54	No	No	0	1	4
288	R:R:I146	R:R:V147	1.54	No	No	0	4	4
289	R:R:I16	R:R:T20	1.52	No	No	0	5	5
290	R:R:F284	R:R:G285	1.51	No	No	0	6	2
291	R:R:G34	R:R:R37	1.5	No	No	0	4	5
292	R:R:L119	R:R:S120	1.5	No	No	0	4	4
293	R:R:G213	R:R:R216	1.5	No	No	0	3	5
294	R:R:G287	R:R:R286	1.5	No	No	0	3	4
295	R:R:L119	R:R:V115	1.49	No	No	0	4	6
296	R:R:L229	R:R:V225	1.49	No	No	0	4	5
297	R:R:I15	R:R:I66	1.47	Yes	No	0	6	7
298	R:R:D170	R:R:T169	1.45	No	No	0	1	4
299	R:R:F113	R:R:P114	1.44	Yes	No	0	6	8
300	R:R:P123	R:R:R122	1.44	No	No	0	2	6
301	R:R:I80	R:R:L84	1.43	No	No	0	4	5
302	R:R:Q116	R:R:V115	1.43	No	No	0	5	6
303	R:R:E154	R:R:T153	1.41	No	No	0	1	6
304	R:R:A31	R:R:R30	1.38	No	No	0	7	4
305	R:R:A214	R:R:R218	1.38	No	No	0	3	5
306	R:R:L268	R:R:L271	1.38	No	No	0	7	7
307	R:R:L150	R:R:N151	1.37	No	No	0	2	5
308	R:R:L150	R:R:N158	1.37	No	No	0	2	2
309	R:R:E68	R:R:K65	1.35	No	Yes	0	5	7
310	R:R:E161	R:R:K79	1.35	No	No	0	3	2
311	R:R:C164	R:R:Y165	1.34	Yes	No	0	9	4
312	R:R:A24	R:R:Y274	1.33	No	No	0	7	7
313	R:R:F64	R:R:I67	1.26	No	No	0	6	4
314	R:R:K118	R:R:R121	1.24	No	No	0	4	7
315	R:R:L131	R:R:W134	1.14	No	No	0	4	9
316	R:R:F73	R:R:R74	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I15	2.88	4	0	6
2	R:R:I17	4.9075	4	1	7
3	R:R:F18	6.0425	4	0	7
4	R:R:L22	4.6825	4	0	6
5	R:R:N25	4.635	4	0	9
6	R:R:F32	7.46	4	2	7
7	R:R:L48	6.6325	4	2	8
8	R:R:L51	5.1825	4	1	9
9	R:R:D55	4.685	6	1	9
10	R:R:L58	5.3275	4	0	7
11	R:R:L59	3.9575	4	0	6
12	R:R:L62	4.216	5	1	8
13	R:R:K65	7.93	4	1	7
14	R:R:F87	3.614	5	0	6
15	R:R:F89	7.244	5	1	7
16	R:R:Y90	6.25833	6	1	5
17	R:R:Y94	5.822	5	1	8
18	R:R:C95	4.82	4	0	7
19	R:R:W98	6.53	4	1	5
20	R:R:L100	3.9975	4	1	8
21	R:R:F113	5.3375	4	0	6
22	R:R:H140	7.3125	4	1	4
23	R:R:Q148	14.16	4	1	5
24	R:R:Y149	8.45	4	5	5
25	R:R:N160	7.526	5	1	5
26	R:R:I162	5.365	4	1	4
27	R:R:T163	4.8175	4	1	4
28	R:R:C164	5.3725	4	3	9
29	R:R:E166	4.0675	4	1	5
30	R:R:R180	9.848	5	1	5
31	R:R:C184	4.13	4	0	6
32	R:R:L187	5.69167	6	1	6
33	R:R:P191	5.23	4	0	9
34	R:R:Y199	8.382	5	4	8
35	R:R:V212	4.91	4	0	3
36	R:R:F231	4.6225	4	1	9
37	R:R:F235	8.035	4	1	9
38	R:R:Y238	5.33286	7	1	7
39	R:R:N239	7.9325	4	1	8
40	R:R:S241	4.255	4	1	5
41	R:R:H242	6.2875	4	0	6
42	R:R:P252	4.148	5	1	1
43	R:R:W254	4.265	4	1	4
44	R:R:R255	6.65833	6	1	5
45	R:R:N265	7.342	5	1	9
46	R:R:D269	7.0775	4	1	9
47	L:L:?1	6.71125	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I10	R:R:V260	15.8438	3.07	No	No	0	5	5
2	R:R:V260	R:R:Y14	19.2522	5.05	No	No	0	5	8
3	R:R:K65	R:R:Y14	20.9409	11.94	Yes	No	0	7	8
4	R:R:F89	R:R:L62	42.1762	4.87	Yes	Yes	1	7	8
5	R:R:F18	R:R:L62	18.0954	6.09	Yes	Yes	0	7	8
6	R:R:F18	R:R:I66	14.8368	3.77	Yes	No	0	7	7
7	R:R:I15	R:R:I66	12.389	1.47	Yes	No	0	6	7
8	R:R:L59	R:R:L62	32.8961	2.77	Yes	Yes	0	6	8
9	R:R:L22	R:R:L59	10.2458	4.15	Yes	Yes	0	6	6
10	R:R:A24	R:R:P270	22.4695	3.74	No	No	0	7	9
11	R:R:N25	R:R:P270	24.4836	4.89	Yes	No	0	9	9
12	R:R:L59	R:R:N25	34.0064	5.49	Yes	Yes	0	6	9
13	R:R:D55	R:R:N25	29.307	4.04	Yes	Yes	0	9	9
14	R:R:A24	R:R:Y274	20.4452	1.33	No	No	0	7	7
15	R:R:L27	R:R:Y274	18.4105	4.69	No	No	0	6	7
16	R:R:F32	R:R:L48	20.4038	14.61	Yes	Yes	2	7	8
17	R:R:I103	R:R:L48	43.8133	2.85	No	Yes	0	9	8
18	R:R:I103	R:R:R107	52.9746	2.51	No	No	0	9	9
19	R:R:R107	R:R:T227	47.7484	3.88	No	No	4	9	7
20	R:R:L272	R:R:T227	94.9855	4.42	No	No	0	8	7
21	R:R:L272	R:R:N230	96.7052	2.75	No	No	0	8	7
22	R:R:C234	R:R:N230	99.1944	4.72	No	No	0	8	7
23	R:R:C234	R:R:N265	100	3.15	No	Yes	0	8	9
24	R:R:F235	R:R:N265	84.8843	13.29	Yes	Yes	1	9	9
25	R:R:F235	R:R:S262	77.6441	3.96	Yes	No	1	9	8
26	R:R:S262	R:R:Y238	73.8484	3.82	No	Yes	1	8	7
27	R:R:Y238	R:R:Y90	21.225	9.93	Yes	Yes	1	7	5
28	R:R:K65	R:R:Y90	20.5743	4.78	Yes	Yes	1	7	5
29	R:R:F32	R:R:T52	17.4344	3.89	Yes	No	0	7	8
30	R:R:L29	R:R:T52	11.1909	2.95	No	No	0	7	8
31	R:R:H45	R:R:V44	22.8414	2.77	No	No	0	7	7
32	R:R:L48	R:R:V44	23.1564	2.98	Yes	No	0	8	7
33	R:R:A42	R:R:H45	19.7015	4.39	No	No	0	7	7
34	R:R:A42	R:R:P43	18.1161	1.87	No	No	0	7	7
35	R:R:G126	R:R:P43	13.2979	2.03	No	No	0	8	7
36	R:R:G126	R:R:I46	10.0341	5.29	No	No	0	8	7
37	L:L:?1	R:R:Y90	32.8754	7.55	Yes	Yes	1	0	5
38	L:L:?1	R:R:F87	27.3549	1.74	Yes	Yes	0	0	6
39	R:R:F138	R:R:F87	17.7391	6.43	No	Yes	0	3	6
40	R:R:F138	R:R:W134	13.3805	5.01	No	No	0	3	9
41	R:R:F188	R:R:N239	11.0773	18.12	No	Yes	0	8	8
42	R:R:F188	R:R:F231	11.3923	6.43	No	Yes	0	8	9
43	R:R:F64	R:R:V81	12.3477	3.93	No	No	0	6	6
44	R:R:P78	R:R:V81	15.41	12.37	No	No	0	8	6
45	R:R:L77	R:R:P78	18.4621	1.64	No	No	0	7	8
46	R:R:C164	R:R:L77	21.5038	3.17	Yes	No	0	9	7
47	R:R:C164	R:R:K79	30.5154	9.7	Yes	No	3	9	2
48	R:R:E161	R:R:K79	36.5575	1.35	No	No	0	3	2
49	R:R:E161	R:R:Y149	39.5373	10.1	No	Yes	0	3	5
50	R:R:T152	R:R:Y149	57.1989	4.99	No	Yes	0	3	5
51	R:R:I162	R:R:T152	60.1064	4.56	Yes	No	0	4	3
52	R:R:I162	R:R:Q148	27.107	9.61	Yes	Yes	1	4	5
53	L:L:?1	R:R:Q148	32.1679	22.87	Yes	Yes	1	0	5
54	R:R:I162	R:R:T163	35.4885	3.04	Yes	Yes	1	4	4
55	L:L:?1	R:R:T163	28.1967	6.33	Yes	Yes	1	0	4
56	R:R:E166	R:R:Y90	12.3477	3.37	Yes	Yes	1	5	5
57	R:R:Y238	R:R:Y94	15.8335	5.96	Yes	Yes	1	7	8
58	R:R:L187	R:R:Y94	12.7608	8.21	Yes	Yes	1	6	8
59	R:R:F235	R:R:T97	10.4627	11.67	Yes	No	1	9	8
60	R:R:T227	R:R:Y199	46.3592	9.99	No	Yes	4	7	8
61	R:R:S104	R:R:Y199	24.2512	13.99	No	Yes	0	9	8
62	R:R:C198	R:R:S104	21.2973	5.16	No	No	0	8	9
63	R:R:A112	R:R:Y108	13.4218	5.34	No	No	0	7	8
64	R:R:C198	R:R:Y108	18.2865	6.72	No	No	0	8	8
65	R:R:A224	R:R:F202	18.8081	2.77	No	No	0	7	8
66	R:R:A224	R:R:Y199	24.7883	2.67	No	Yes	0	7	8
67	R:R:A112	R:R:F113	11.7796	6.93	No	Yes	0	7	6
68	R:R:R255	R:R:Y238	17.517	5.14	Yes	Yes	1	5	7
69	L:L:?1	R:R:R255	11.7693	4.35	Yes	Yes	1	0	5
70	R:R:C184	R:R:N239	12.9415	3.15	Yes	Yes	0	6	8
71	R:R:F202	R:R:M206	14.3462	6.22	No	No	0	8	8
72	R:R:M206	R:R:V212	11.2373	3.04	No	Yes	0	8	3
73	R:R:I10	R:R:I257	10.6538	2.94	No	No	0	5	5
74	R:R:R255	R:R:S241	14.8678	3.95	Yes	Yes	1	5	5
75	R:R:P252	R:R:R255	17.6926	5.76	Yes	Yes	1	1	5
76	R:R:S241	R:R:W254	14.0002	4.94	Yes	Yes	1	5	4
77	R:R:P252	R:R:W254	12.9777	4.05	Yes	Yes	1	1	4
78	R:R:V244	R:R:W254	18.0283	2.45	No	Yes	0	5	4
79	R:R:F284	R:R:R281	12.327	3.21	No	No	0	6	8
80	R:R:L27	R:R:R281	16.3499	2.43	No	No	0	6	8
81	R:R:D55	R:R:N265	30.3295	2.69	Yes	Yes	1	9	9
82	R:R:F89	R:R:Y90	42.3363	3.09	Yes	Yes	1	7	5
83	L:L:?1	R:R:Y238	59.1097	4.2	Yes	Yes	1	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F89	R:R:K65	13.65	1	Yes	Yes	7	7	2	2
R:R:K65	R:R:Y90	4.78	1	Yes	Yes	7	5	2	1
R:R:F87	R:R:G88	4.52	0	Yes	No	6	5	1	2
R:R:F138	R:R:F87	6.43	0	No	Yes	3	6	2	1
R:R:C141	R:R:F87	2.79	0	No	Yes	7	6	2	1
R:R:F89	R:R:Y90	3.09	1	Yes	Yes	7	5	2	1
R:R:E166	R:R:Y90	3.37	1	Yes	Yes	5	5	1	1
R:R:Y238	R:R:Y90	9.93	1	Yes	Yes	7	5	1	1
R:R:V259	R:R:Y90	8.83	0	No	Yes	5	5	2	1
L:L:?1	R:R:Y90	7.55	1	Yes	Yes	0	5	0	1
R:R:I93	R:R:Y238	3.63	1	No	Yes	8	7	2	1
R:R:I93	R:R:S262	6.19	1	No	No	8	8	2	2
R:R:Y238	R:R:Y94	5.96	1	Yes	Yes	7	8	1	2
R:R:N239	R:R:Y94	5.81	1	Yes	Yes	8	8	2	2
R:R:H242	R:R:Y94	3.27	0	Yes	Yes	6	8	2	2
L:L:?1	R:R:V144	11.73	1	Yes	No	0	5	0	1
R:R:I145	R:R:N160	8.5	0	No	Yes	4	5	1	2
L:L:?1	R:R:I145	4.09	1	Yes	No	0	4	0	1
R:R:N151	R:R:V147	2.96	0	No	No	5	4	2	1
L:L:?1	R:R:V147	5.33	1	Yes	No	0	4	0	1
R:R:N160	R:R:Q148	18.49	1	Yes	Yes	5	5	2	1
R:R:I162	R:R:Q148	9.61	1	Yes	Yes	4	5	2	1
R:R:Q148	R:R:T163	5.67	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:Q148	22.87	1	Yes	Yes	0	5	0	1
R:R:I162	R:R:N160	4.25	1	Yes	Yes	4	5	2	2
R:R:I162	R:R:T163	3.04	1	Yes	Yes	4	4	2	1
R:R:E166	R:R:T163	4.23	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:T163	6.33	1	Yes	Yes	0	4	0	1
R:R:E166	R:R:R255	5.82	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:E166	2.85	1	Yes	Yes	0	5	0	1
R:R:F168	R:R:Q172	10.54	1	No	No	4	1	1	1
L:L:?1	R:R:F168	3.49	1	Yes	No	0	4	0	1
L:L:?1	R:R:Q172	4.76	1	Yes	No	0	1	0	1
L:L:?1	R:R:V175	6.4	1	Yes	No	0	3	0	1
R:R:L177	R:R:V176	2.98	0	No	No	2	4	2	1
R:R:R180	R:R:V176	6.54	1	Yes	No	5	4	1	1
L:L:?1	R:R:V176	8.53	1	Yes	No	0	4	0	1
L:L:?1	R:R:V179	5.33	1	Yes	No	0	4	0	1
R:R:H242	R:R:R180	14.67	0	Yes	Yes	6	5	2	1
R:R:R180	R:R:S251	5.27	1	Yes	No	5	4	1	2
R:R:R180	R:R:R255	14.93	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:R180	7.83	1	Yes	Yes	0	5	0	1
R:R:N239	R:R:Y238	4.65	1	Yes	Yes	8	7	2	1
R:R:R255	R:R:Y238	5.14	1	Yes	Yes	5	7	1	1
R:R:S262	R:R:Y238	3.82	1	No	Yes	8	7	2	1
L:L:?1	R:R:Y238	4.2	1	Yes	Yes	0	7	0	1
R:R:H242	R:R:S241	2.79	0	Yes	Yes	6	5	2	2
R:R:P252	R:R:S241	5.34	1	Yes	Yes	1	5	2	2
R:R:R255	R:R:S241	3.95	1	Yes	Yes	5	5	1	2
R:R:P252	R:R:S251	3.56	1	Yes	No	1	4	2	2
R:R:P252	R:R:R255	5.76	1	Yes	Yes	1	5	2	1
L:L:?1	R:R:R255	4.35	1	Yes	Yes	0	5	0	1
R:R:F87	R:R:T142	2.59	0	Yes	No	6	4	1	2
R:R:F168	R:R:L173	2.44	1	No	No	4	1	1	2
L:L:?1	R:R:F87	1.74	1	Yes	Yes	0	6	0	1
R:R:I146	R:R:V147	1.54	0	No	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8J22_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.67
Number of Linked Nodes	273
Number of Links	316
Number of Hubs	47
Number of Links mediated by Hubs	160
Number of Communities	7
Number of Nodes involved in Communities	57
Number of Links involved in Communities	84

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	49593
Length Of Smallest Path	3
Average Path Length	12.9899
Length of Longest Path	34
Minimum Path Strength	1.37
Average Path Strength	5.30119
Maximum Path Strength	20.68
Minimum Path Correlation	0.7
Average Path Correlation	0.941038
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	56.9146
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.7095
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lipid binding • positive regulation of response to biotic stimulus • immune response-regulating cell surface receptor signaling pathway • pattern recognition receptor signaling pathway • response to biotic stimulus • immune response-activating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • innate immune response-activating signaling pathway • immune response • response to other organism • immune response-activating cell surface receptor signaling pathway • regulation of innate immune response • response to external stimulus • regulation of response to stimulus • defense response to other organism • positive regulation of defense response • activation of innate immune response • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of response to external stimulus • innate immune response activating cell surface receptor signaling pathway • positive regulation of response to stimulus • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of response to stress • response to stress • innate immune response • response to external biotic stimulus • cell surface pattern recognition receptor signaling pathway • positive regulation of innate immune response • cell surface receptor signaling pathway • defense response • defense response to symbiont • multicellular organismal process • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of multicellular organismal process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of interleukin-8 production • regulation of chemokine production • chemokine production • positive regulation of chemokine production • cell chemotaxis • leukocyte chemotaxis involved in inflammatory response • chemotaxis • leukocyte migration involved in inflammatory response • taxis • inflammatory response • leukocyte chemotaxis • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • mucosal immune response • organ or tissue specific immune response • lipid storage • nutrient storage • positive regulation of acute inflammatory response • positive regulation of inflammatory response • regulation of acute inflammatory response to non-antigenic stimulus • acute inflammatory response • acute inflammatory response to non-antigenic stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response to non-antigenic stimulus • regulation of acute inflammatory response • response to fatty acid • cellular response to fatty acid • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • regulation of immune effector process • positive regulation of immune effector process • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune effector process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9UJ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	9UJ
Name	(2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid
Synonyms	TUG-1375
Identifier
Formula	C22 H19 Cl N2 O4 S
Molecular Weight	442.915
SMILES
PubChem	138319694
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>8J22_nogp_Chain_R S S L I L M A Y I I I F L T G L P A N L L A L R A F V G V V R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N F R W Y L P K I V C A L T G F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T T E Q V R N G N E I T C Y E N F T D E Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L T Q P H V G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G F Y Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F S S S V V R R A F G R G L Q V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187	Gi1/β1/γ2	3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187		3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729	Gi1/β1/γ2	3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729		3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	8Y6W	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	Gi1/β1/γ2	3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6W (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	9CLW	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CLW (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	-	Gi1/β1/γ2	3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butanoic acid	-		3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8Y6Y	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	GLPG0974	-	-	3.36	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published

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