psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y90	20.15	Yes	Yes	1	0	5
2	L:L:?1	R:R:C141	3.64	Yes	No	0	0	7
3	L:L:?1	R:R:V144	13.66	Yes	Yes	1	0	5
4	L:L:?1	R:R:I145	3.27	Yes	No	0	0	4
5	L:L:?1	R:R:Q148	4.58	Yes	Yes	1	0	5
6	L:L:?1	R:R:R180	15.32	Yes	Yes	1	0	5
7	L:L:?1	R:R:L183	6.35	Yes	Yes	1	0	5
8	L:L:?1	R:R:Y238	12.09	Yes	Yes	1	0	7
9	L:L:?1	R:R:H242	7.37	Yes	Yes	1	0	6
10	L:L:?1	R:R:R255	12.53	Yes	Yes	1	0	5
11	R:R:P3	R:R:S8	3.56	No	No	0	8	5
12	R:R:D4	R:R:S7	8.83	No	No	0	4	3
13	R:R:K6	R:R:W5	19.73	Yes	No	0	5	7
14	R:R:I257	R:R:K6	10.18	No	Yes	0	5	5
15	R:R:I10	R:R:Y14	4.84	No	Yes	0	5	8
16	R:R:A69	R:R:I10	3.25	No	No	0	5	5
17	R:R:A70	R:R:L11	4.73	No	No	0	4	5
18	R:R:L62	R:R:Y14	10.55	No	Yes	1	8	8
19	R:R:K65	R:R:Y14	8.36	Yes	Yes	1	7	8
20	R:R:I66	R:R:Y14	4.84	Yes	Yes	0	7	8
21	R:R:V259	R:R:Y14	3.79	Yes	Yes	1	5	8
22	R:R:V260	R:R:Y14	6.31	No	Yes	0	5	8
23	R:R:I15	R:R:I66	5.89	No	Yes	0	6	7
24	R:R:I17	R:R:L264	4.28	No	Yes	1	7	5
25	R:R:I17	R:R:S267	3.1	No	No	1	7	8
26	R:R:F18	R:R:L19	3.65	Yes	No	0	7	4
27	R:R:F18	R:R:L22	4.87	Yes	No	0	7	6
28	R:R:F18	R:R:P63	7.22	Yes	No	0	7	9
29	R:R:F18	R:R:I66	3.77	Yes	Yes	0	7	7
30	R:R:A24	R:R:P270	3.74	No	No	0	7	9
31	R:R:L56	R:R:N25	5.49	No	No	0	7	9
32	R:R:L59	R:R:N25	4.12	No	No	0	6	9
33	R:R:N25	R:R:P270	6.52	No	No	0	9	9
34	R:R:L26	R:R:L56	4.15	No	No	0	4	7
35	R:R:L27	R:R:Y274	3.52	No	Yes	1	6	7
36	R:R:F275	R:R:L27	3.65	Yes	No	1	7	6
37	R:R:A28	R:R:F32	4.16	No	Yes	1	8	7
38	R:R:A28	R:R:T52	3.36	No	No	1	8	8
39	R:R:A28	R:R:Y274	6.67	No	Yes	1	8	7
40	R:R:L29	R:R:L53	4.15	No	No	0	7	6
41	R:R:A31	R:R:Y274	4	No	Yes	0	7	7
42	R:R:F32	R:R:L48	12.18	Yes	Yes	1	7	8
43	R:R:F32	R:R:T52	6.49	Yes	No	1	7	8
44	R:R:F32	R:R:Y274	4.13	Yes	Yes	1	7	7
45	R:R:Q38	R:R:R35	15.19	No	No	0	5	5
46	R:R:H45	R:R:R35	18.05	No	No	0	7	5
47	R:R:I36	R:R:P41	6.77	Yes	No	0	5	6
48	R:R:A42	R:R:H45	4.39	No	No	0	7	7
49	R:R:A42	R:R:R121	5.53	No	Yes	0	7	7
50	R:R:E106	R:R:P43	11	No	No	0	8	7
51	R:R:P43	R:R:R121	4.32	No	Yes	0	7	7
52	R:R:G126	R:R:P43	4.06	No	No	0	8	7
53	R:R:L48	R:R:V44	2.98	Yes	No	0	8	7
54	R:R:E106	R:R:V44	5.7	No	No	0	8	7
55	R:R:I46	R:R:V127	3.07	No	No	0	7	4
56	R:R:I103	R:R:L48	4.28	No	Yes	1	9	8
57	R:R:F273	R:R:L48	6.09	Yes	Yes	1	9	8
58	R:R:L49	R:R:L53	4.15	No	No	0	6	6
59	R:R:L99	R:R:S50	3	No	No	0	8	9
60	R:R:A130	R:R:S50	3.42	No	No	0	7	9
61	R:R:S50	R:R:W134	3.71	No	Yes	0	9	9
62	R:R:D55	R:R:L51	8.14	Yes	Yes	1	9	9
63	R:R:L51	R:R:S96	3	Yes	No	1	9	9
64	R:R:L51	R:R:L99	4.15	Yes	No	0	9	8
65	R:R:D269	R:R:L51	10.86	No	Yes	1	9	9
66	R:R:A54	R:R:C95	3.61	No	No	2	8	7
67	R:R:A54	R:R:W134	3.89	No	Yes	2	8	9
68	R:R:D55	R:R:S96	4.42	Yes	No	1	9	9
69	R:R:A266	R:R:D55	4.63	No	Yes	0	8	9
70	R:R:D269	R:R:D55	10.65	No	Yes	1	9	9
71	R:R:F89	R:R:L58	8.53	Yes	No	1	7	7
72	R:R:L58	R:R:S92	9.01	No	No	0	7	8
73	R:R:L58	R:R:S263	3	No	No	1	7	6
74	R:R:A266	R:R:L59	3.15	No	No	0	8	6
75	R:R:F89	R:R:L62	4.87	Yes	No	1	7	8
76	R:R:L62	R:R:S263	3	No	No	1	8	6
77	R:R:F64	R:R:V81	3.93	No	No	0	6	6
78	R:R:F64	R:R:T85	14.27	No	No	0	6	5
79	R:R:F89	R:R:K65	8.69	Yes	Yes	1	7	7
80	R:R:K65	R:R:Y90	8.36	Yes	Yes	1	7	5
81	R:R:K65	R:R:V259	4.55	Yes	Yes	1	7	5
82	R:R:P78	R:R:V81	12.37	No	No	0	8	6
83	R:R:K79	R:R:V80	3.04	No	No	0	2	4
84	R:R:K79	R:R:Y149	13.14	No	No	0	2	5
85	R:R:L84	R:R:V80	2.98	No	No	0	5	4
86	R:R:C164	R:R:C82	7.28	No	No	0	9	9
87	R:R:S86	R:R:Y90	5.09	No	Yes	0	6	5
88	R:R:F87	R:R:G88	4.52	Yes	No	0	6	5
89	R:R:F87	R:R:S91	5.28	Yes	No	2	6	5
90	R:R:F138	R:R:F87	3.22	Yes	Yes	2	3	6
91	R:R:F87	R:R:T142	5.19	Yes	No	0	6	4
92	R:R:F87	R:R:I145	5.02	Yes	No	0	6	4
93	R:R:F89	R:R:Y90	6.19	Yes	Yes	1	7	5
94	R:R:F89	R:R:V259	3.93	Yes	Yes	1	7	5
95	R:R:F89	R:R:S263	3.96	Yes	No	1	7	6
96	R:R:Y238	R:R:Y90	13.9	Yes	Yes	1	7	5
97	R:R:R255	R:R:Y90	5.14	Yes	Yes	1	5	5
98	R:R:V259	R:R:Y90	3.79	Yes	Yes	1	5	5
99	R:R:F138	R:R:S91	6.61	Yes	No	2	3	5
100	R:R:C141	R:R:S91	3.44	No	No	0	7	5
101	R:R:I93	R:R:Y94	3.63	No	Yes	1	8	8
102	R:R:I93	R:R:Y238	6.04	No	Yes	1	8	7
103	R:R:I93	R:R:S262	9.29	No	No	1	8	8
104	R:R:L183	R:R:Y94	5.86	Yes	Yes	1	5	8
105	R:R:L187	R:R:Y94	8.21	No	Yes	0	6	8
106	R:R:Y238	R:R:Y94	7.94	Yes	Yes	1	7	8
107	R:R:N239	R:R:Y94	11.63	No	Yes	0	8	8
108	R:R:H242	R:R:Y94	4.36	Yes	Yes	1	6	8
109	R:R:C95	R:R:W134	10.45	No	Yes	2	7	9
110	R:R:C95	R:R:S137	5.16	No	No	0	7	7
111	R:R:P191	R:R:T97	3.5	Yes	No	1	9	8
112	R:R:F231	R:R:T97	3.89	Yes	No	1	9	8
113	R:R:F235	R:R:T97	14.27	Yes	No	1	9	8
114	R:R:M136	R:R:W98	4.65	No	Yes	0	4	5
115	R:R:L187	R:R:W98	4.56	No	Yes	0	6	5
116	R:R:I190	R:R:W98	5.87	No	Yes	1	5	5
117	R:R:P191	R:R:W98	14.86	Yes	Yes	1	9	5
118	R:R:A133	R:R:L99	3.15	No	No	0	7	8
119	R:R:F231	R:R:L100	6.09	Yes	Yes	1	9	8
120	R:R:F235	R:R:L100	3.65	Yes	Yes	1	9	8
121	R:R:L100	R:R:N265	5.49	Yes	Yes	1	8	9
122	R:R:F273	R:R:L100	3.65	Yes	Yes	1	9	8
123	R:R:A101	R:R:V194	3.39	No	No	0	8	6
124	R:R:F273	R:R:I103	7.54	Yes	No	1	9	9
125	R:R:S104	R:R:T195	9.59	No	No	0	9	7
126	R:R:S104	R:R:Y199	11.45	No	Yes	0	9	8
127	R:R:I105	R:R:V194	3.07	No	No	0	6	6
128	R:R:C198	R:R:I105	3.27	No	No	0	8	6
129	R:R:E106	R:R:Y117	11.22	No	No	0	8	5
130	R:R:R107	R:R:Y199	11.32	No	Yes	1	9	8
131	R:R:R107	R:R:T227	3.88	No	No	1	9	7
132	R:R:F273	R:R:R107	8.55	Yes	No	1	9	9
133	R:R:L109	R:R:Y108	3.52	No	Yes	0	6	8
134	R:R:A112	R:R:Y108	5.34	No	Yes	0	7	8
135	R:R:C198	R:R:Y108	5.38	No	Yes	0	8	8
136	R:R:R201	R:R:Y108	6.17	Yes	Yes	0	4	8
137	R:R:G110	R:R:Y117	7.24	No	No	0	8	5
138	R:R:F202	R:R:V111	7.87	No	No	4	8	8
139	R:R:I205	R:R:V111	3.07	No	No	0	5	8
140	R:R:M206	R:R:V111	4.56	No	No	4	8	8
141	R:R:A112	R:R:F113	8.32	No	No	0	7	6
142	R:R:R121	R:R:Y117	8.23	Yes	No	0	7	5
143	R:R:K118	R:R:R121	6.19	No	Yes	0	4	7
144	R:R:R122	R:R:Y125	8.23	No	No	0	6	4
145	R:R:I128	R:R:L124	7.14	No	No	0	1	3
146	R:R:L131	R:R:V127	2.98	No	No	0	4	4
147	R:R:F138	R:R:W134	7.02	Yes	Yes	2	3	9
148	R:R:H140	R:R:M136	5.25	No	No	0	4	4
149	R:R:E182	R:R:H140	11.08	No	No	0	4	4
150	R:R:H140	R:R:L187	14.14	No	No	0	4	6
151	R:R:Q148	R:R:V144	4.3	Yes	Yes	1	5	5
152	R:R:V144	R:R:V179	6.41	Yes	No	1	5	4
153	R:R:L183	R:R:V144	4.47	Yes	Yes	1	5	5
154	R:R:V147	R:R:V175	3.21	Yes	No	1	4	3
155	R:R:F168	R:R:Q148	9.37	Yes	Yes	1	4	5
156	R:R:Q148	R:R:V176	4.3	Yes	Yes	1	5	4
157	R:R:Q148	R:R:R180	4.67	Yes	Yes	1	5	5
158	R:R:L150	R:R:Y149	8.21	No	No	0	2	5
159	R:R:E166	R:R:F168	8.16	No	Yes	0	5	4
160	R:R:F168	R:R:L173	3.65	Yes	No	0	4	1
161	R:R:F168	R:R:V176	3.93	Yes	Yes	1	4	4
162	R:R:F168	R:R:R180	3.21	Yes	Yes	1	4	5
163	R:R:Q172	R:R:T169	5.67	No	No	0	1	4
164	R:R:N171	R:R:Q172	3.96	No	No	0	3	1
165	R:R:L173	R:R:L177	8.3	No	No	0	1	2
166	R:R:R180	R:R:V176	5.23	Yes	Yes	1	5	4
167	R:R:H242	R:R:R180	10.16	Yes	Yes	1	6	5
168	R:R:R180	R:R:S251	3.95	Yes	No	0	5	4
169	R:R:R180	R:R:R255	19.19	Yes	Yes	1	5	5
170	R:R:L181	R:R:L185	5.54	No	No	0	5	5
171	R:R:L181	R:R:L243	4.15	No	No	0	5	5
172	R:R:L181	R:R:Y246	4.69	No	No	0	5	4
173	R:R:E182	R:R:V186	8.56	No	No	0	4	4
174	R:R:H242	R:R:L183	3.86	Yes	Yes	1	6	5
175	R:R:C184	R:R:F189	4.19	No	No	0	6	4
176	R:R:C184	R:R:N239	4.72	No	No	0	6	8
177	R:R:C184	R:R:L243	3.17	No	No	0	6	5
178	R:R:F188	R:R:F189	5.36	No	No	0	8	4
179	R:R:F188	R:R:M192	8.71	No	No	0	8	6
180	R:R:F188	R:R:N239	27.79	No	No	0	8	8
181	R:R:I190	R:R:P191	3.39	No	Yes	1	5	9
182	R:R:F231	R:R:M192	4.98	Yes	No	0	9	6
183	R:R:F231	R:R:T195	9.08	Yes	No	0	9	7
184	R:R:I196	R:R:L228	5.71	No	No	0	4	8
185	R:R:F197	R:R:R201	3.21	No	Yes	0	5	4
186	R:R:T227	R:R:Y199	8.74	No	Yes	1	7	8
187	R:R:L228	R:R:Y199	7.03	No	Yes	0	8	8
188	R:R:R201	R:R:W200	10	Yes	No	3	4	3
189	R:R:W200	R:R:W204	4.69	No	No	3	3	3
190	R:R:R201	R:R:W204	6	Yes	No	3	4	3
191	R:R:F202	R:R:M206	9.95	No	No	4	8	8
192	R:R:L207	R:R:V203	2.98	No	Yes	5	4	5
193	R:R:V203	R:R:V221	4.81	Yes	No	5	5	4
194	R:R:I205	R:R:Q209	4.12	No	No	0	5	5
195	R:R:L207	R:R:V221	2.98	No	No	5	4	4
196	R:R:P210	R:R:Q209	3.16	No	No	0	3	5
197	R:R:Q209	R:R:R217	3.5	No	No	0	5	6
198	R:R:G213	R:R:R217	3	No	No	0	3	6
199	R:R:A214	R:R:R217	5.53	No	No	0	3	6
200	R:R:Q215	R:R:R216	7.01	No	No	0	4	5
201	R:R:R216	R:R:R218	9.6	No	No	0	5	5
202	R:R:R216	R:R:R219	18.13	No	No	0	5	7
203	R:R:L223	R:R:S276	6.01	No	No	0	7	7
204	R:R:L272	R:R:V226	2.98	No	No	0	8	5
205	R:R:C234	R:R:N230	4.72	No	No	1	8	7
206	R:R:N230	R:R:N265	6.81	No	Yes	1	7	9
207	R:R:L268	R:R:N230	5.49	No	No	1	7	7
208	R:R:F231	R:R:F235	5.36	Yes	Yes	1	9	9
209	R:R:C234	R:R:L264	3.17	No	Yes	1	8	5
210	R:R:C234	R:R:N265	4.72	No	Yes	1	8	9
211	R:R:F235	R:R:S262	3.96	Yes	No	1	9	8
212	R:R:F235	R:R:N265	12.08	Yes	Yes	1	9	9
213	R:R:G236	R:R:P237	4.06	No	No	0	5	9
214	R:R:H242	R:R:Y238	3.27	Yes	Yes	1	6	7
215	R:R:R255	R:R:Y238	10.29	Yes	Yes	1	5	7
216	R:R:S262	R:R:Y238	7.63	No	Yes	1	8	7
217	R:R:P252	R:R:S241	3.56	Yes	No	1	1	5
218	R:R:S241	R:R:W254	8.65	No	Yes	1	5	4
219	R:R:H242	R:R:R255	4.51	Yes	Yes	1	6	5
220	R:R:Q248	R:R:V244	5.73	No	No	0	3	5
221	R:R:G245	R:R:P252	4.06	No	Yes	0	5	1
222	R:R:R249	R:R:Y246	19.55	No	No	0	4	4
223	R:R:K250	R:R:Q248	5.42	No	No	0	2	3
224	R:R:K250	R:R:W253	4.64	No	No	0	2	1
225	R:R:P252	R:R:W254	13.51	Yes	Yes	1	1	4
226	R:R:P252	R:R:R255	5.76	Yes	Yes	1	1	5
227	R:R:W253	R:R:W254	14.99	No	Yes	0	1	4
228	R:R:L264	R:R:S267	3	Yes	No	1	5	8
229	R:R:L264	R:R:L268	4.15	Yes	No	1	5	7
230	R:R:D269	R:R:N265	12.12	No	Yes	1	9	9
231	R:R:L268	R:R:S267	3	No	No	1	7	8
232	R:R:F275	R:R:L271	4.87	Yes	No	0	7	7
233	R:R:F275	R:R:Y274	10.32	Yes	Yes	1	7	7
234	R:R:F275	R:R:V279	3.93	Yes	No	0	7	5
235	R:R:L29	R:R:T52	2.95	No	No	0	7	8
236	R:R:L272	R:R:T227	2.95	No	No	0	8	7
237	R:R:I36	R:R:I46	2.94	Yes	No	0	5	7
238	R:R:I10	R:R:K6	2.91	No	Yes	0	5	5
239	R:R:I103	R:R:L47	2.85	No	No	0	9	7
240	R:R:I196	R:R:L232	2.85	No	No	0	4	5
241	R:R:K6	R:R:L9	2.82	Yes	No	0	5	6
242	R:R:L57	R:R:L61	2.77	No	No	0	7	7
243	R:R:A224	R:R:F202	2.77	No	No	0	7	8
244	R:R:A224	R:R:Y199	2.67	No	Yes	0	7	8
245	R:R:E68	R:R:N72	2.63	No	No	0	5	3
246	R:R:A258	R:R:W254	2.59	No	Yes	0	7	4
247	R:R:S208	R:R:W204	2.47	No	No	0	4	3
248	R:R:V240	R:R:W254	2.45	No	Yes	0	6	4
249	R:R:F138	R:R:L57	2.44	Yes	No	0	3	7
250	R:R:L26	R:R:R30	2.43	No	No	0	4	4
251	R:R:L223	R:R:R219	2.43	No	No	0	7	7
252	R:R:A24	R:R:G21	1.95	No	No	0	7	8
253	R:R:P123	R:R:P41	1.95	No	No	0	2	6
254	R:R:A101	R:R:P191	1.87	No	Yes	0	8	9
255	R:R:A258	R:R:P237	1.87	No	No	0	7	9
256	R:R:G21	R:R:T20	1.82	No	No	0	8	5
257	R:R:G139	R:R:T142	1.82	No	No	0	4	4
258	R:R:G126	R:R:I46	1.76	No	No	0	8	7
259	R:R:G102	R:R:L47	1.71	No	No	0	6	7
260	R:R:A13	R:R:V260	1.7	No	No	0	4	5
261	R:R:A224	R:R:V203	1.7	No	Yes	0	7	5
262	R:R:L22	R:R:P23	1.64	No	No	0	6	4
263	R:R:L77	R:R:P78	1.64	No	No	0	7	8
264	R:R:L177	R:R:P178	1.64	No	No	0	2	2
265	R:R:A83	R:R:I145	1.62	No	No	0	7	4
266	R:R:S277	R:R:V279	1.62	No	No	0	8	5
267	R:R:A220	R:R:M206	1.61	No	No	0	7	8
268	R:R:V147	R:R:V176	1.6	Yes	Yes	1	4	4
269	R:R:V147	R:R:V179	1.6	Yes	No	1	4	4
270	R:R:V175	R:R:V176	1.6	No	Yes	1	3	4
271	R:R:V203	R:R:V225	1.6	Yes	No	0	5	5
272	R:R:P39	R:R:Q38	1.58	No	No	0	3	5
273	R:R:A129	R:R:L47	1.58	No	No	0	5	7
274	R:R:I36	R:R:V33	1.54	Yes	No	0	5	4
275	R:R:I128	R:R:V132	1.54	No	No	0	1	4
276	R:R:I143	R:R:V147	1.54	No	Yes	1	7	4
277	R:R:I143	R:R:V179	1.54	No	No	1	7	4
278	R:R:I146	R:R:V147	1.54	No	Yes	0	4	4
279	R:R:C164	R:R:E68	1.52	No	No	0	9	5
280	R:R:M136	R:R:V132	1.52	No	No	0	4	4
281	R:R:G34	R:R:R37	1.5	No	No	0	4	5
282	R:R:G213	R:R:R218	1.5	No	No	0	3	5
283	R:R:N72	R:R:S71	1.49	No	No	0	3	4
284	R:R:L229	R:R:V225	1.49	No	No	0	4	5
285	R:R:I16	R:R:I17	1.47	No	No	0	5	7
286	R:R:L61	R:R:T85	1.47	No	No	0	7	5
287	R:R:I66	R:R:I67	1.47	Yes	No	0	7	4
288	R:R:G126	R:R:Y125	1.45	No	No	0	8	4
289	R:R:D170	R:R:T169	1.45	No	No	0	1	4
290	R:R:F113	R:R:P114	1.44	No	No	0	6	8
291	R:R:Q116	R:R:S120	1.44	No	No	0	5	4
292	R:R:F261	R:R:P237	1.44	No	No	0	7	9
293	R:R:I15	R:R:L11	1.43	No	No	0	6	5
294	R:R:L11	R:R:M12	1.41	No	No	0	5	5
295	R:R:L60	R:R:L61	1.38	No	No	0	4	7
296	R:R:E68	R:R:K65	1.35	No	Yes	0	5	7
297	R:R:A83	R:R:Y149	1.33	No	No	0	7	5
298	R:R:I36	R:R:R37	1.25	Yes	No	0	5	5
299	R:R:H247	R:R:Q248	1.24	No	No	0	4	3
300	R:R:D174	R:R:R249	1.19	No	No	0	1	4
301	R:R:F113	R:R:Q116	1.17	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.896	10	1	0
2	R:R:K6	8.91	4	0	5
3	R:R:Y14	6.44833	6	1	8
4	R:R:F18	4.8775	4	0	7
5	R:R:F32	6.74	4	1	7
6	R:R:I36	3.125	4	0	5
7	R:R:L48	6.3825	4	1	8
8	R:R:L51	6.5375	4	1	9
9	R:R:D55	6.96	4	1	9
10	R:R:K65	6.262	5	1	7
11	R:R:I66	3.9925	4	0	7
12	R:R:F87	4.646	5	2	6
13	R:R:F89	6.02833	6	1	7
14	R:R:Y90	8.94571	7	1	5
15	R:R:Y94	6.93833	6	1	8
16	R:R:W98	7.485	4	1	5
17	R:R:L100	4.72	4	1	8
18	R:R:Y108	5.1025	4	0	8
19	R:R:R121	6.0675	4	0	7
20	R:R:W134	6.2675	4	2	9
21	R:R:F138	4.8225	4	2	3
22	R:R:V144	7.21	4	1	5
23	R:R:V147	1.898	5	1	4
24	R:R:Q148	5.444	5	1	5
25	R:R:F168	5.664	5	1	4
26	R:R:V176	3.332	5	1	4
27	R:R:R180	8.81857	7	1	5
28	R:R:L183	5.135	4	1	5
29	R:R:P191	5.905	4	1	9
30	R:R:Y199	8.242	5	1	8
31	R:R:R201	6.345	4	3	4
32	R:R:V203	2.7725	4	5	5
33	R:R:F231	5.88	5	1	9
34	R:R:F235	7.864	5	1	9
35	R:R:Y238	8.73714	7	1	7
36	R:R:H242	5.58833	6	1	6
37	R:R:P252	6.7225	4	1	1
38	R:R:W254	8.438	5	1	4
39	R:R:R255	9.57	6	1	5
40	R:R:V259	4.015	4	1	5
41	R:R:L264	3.65	4	1	5
42	R:R:N265	8.244	5	1	9
43	R:R:F273	6.4575	4	1	9
44	R:R:Y274	5.728	5	1	7
45	R:R:F275	5.6925	4	1	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y90	16.8265	20.15	Yes	Yes	1	0	5
2	R:R:K65	R:R:Y90	33.1545	8.36	Yes	Yes	1	7	5
3	R:R:K65	R:R:Y14	26.4223	8.36	Yes	Yes	1	7	8
4	R:R:I10	R:R:Y14	16.1845	4.84	No	Yes	0	5	8
5	R:R:I10	R:R:K6	10.7108	2.91	No	Yes	0	5	5
6	R:R:V259	R:R:Y90	26.8193	3.79	Yes	Yes	1	5	5
7	R:R:V259	R:R:Y14	25.9197	3.79	Yes	Yes	1	5	8
8	R:R:I66	R:R:Y14	29.8518	4.84	Yes	Yes	0	7	8
9	R:R:I15	R:R:I66	11.036	5.89	No	Yes	0	6	7
10	L:L:?1	R:R:Y238	41.1116	12.09	Yes	Yes	1	0	7
11	R:R:S262	R:R:Y238	95.9665	7.63	No	Yes	1	8	7
12	R:R:F235	R:R:S262	100	3.96	Yes	No	1	9	8
13	R:R:F235	R:R:N265	23.6432	12.08	Yes	Yes	1	9	9
14	R:R:F18	R:R:I66	13.7729	3.77	Yes	Yes	0	7	7
15	R:R:D269	R:R:N265	29.0366	12.12	No	Yes	1	9	9
16	R:R:D269	R:R:D55	16.4337	10.65	No	Yes	1	9	9
17	R:R:A266	R:R:D55	15.1159	4.63	No	Yes	0	8	9
18	R:R:A266	R:R:L59	13.6419	3.15	No	No	0	8	6
19	R:R:L59	R:R:N25	12.1595	4.12	No	No	0	6	9
20	R:R:F235	R:R:L100	61.9546	3.65	Yes	Yes	1	9	8
21	R:R:F273	R:R:L100	86.6453	3.65	Yes	Yes	1	9	8
22	R:R:F273	R:R:L48	60.0414	6.09	Yes	Yes	1	9	8
23	R:R:F32	R:R:L48	19.3352	12.18	Yes	Yes	1	7	8
24	R:R:F32	R:R:Y274	10.5545	4.13	Yes	Yes	1	7	7
25	R:R:L48	R:R:V44	43.6795	2.98	Yes	No	0	8	7
26	R:R:E106	R:R:V44	42.3491	5.7	No	No	0	8	7
27	R:R:E106	R:R:P43	28.5847	11	No	No	0	8	7
28	R:R:P43	R:R:R121	10.2673	4.32	No	Yes	0	7	7
29	R:R:A42	R:R:R121	14.4909	5.53	No	Yes	0	7	7
30	R:R:A42	R:R:H45	11.5428	4.39	No	No	0	7	7
31	R:R:E106	R:R:Y117	12.7846	11.22	No	No	0	8	5
32	R:R:R121	R:R:Y117	10.1406	8.23	Yes	No	0	7	5
33	R:R:G126	R:R:P43	17.8401	4.06	No	No	0	8	7
34	R:R:G126	R:R:I46	13.4434	1.76	No	No	0	8	7
35	L:L:?1	R:R:C141	21.6962	3.64	Yes	No	0	0	7
36	R:R:C141	R:R:S91	20.1926	3.44	No	No	0	7	5
37	R:R:F138	R:R:S91	18.7313	6.61	Yes	No	2	3	5
38	R:R:F138	R:R:W134	15.3693	7.02	Yes	Yes	2	3	9
39	R:R:S50	R:R:W134	11.2472	3.71	No	Yes	0	9	9
40	L:L:?1	R:R:I145	35.6084	3.27	Yes	No	0	0	4
41	R:R:F87	R:R:I145	25.5776	5.02	Yes	No	0	6	4
42	R:R:F138	R:R:F87	19.8463	3.22	Yes	Yes	2	3	6
43	R:R:D269	R:R:L51	11.3824	10.86	No	Yes	1	9	9
44	R:R:F138	R:R:L57	28.0652	2.44	Yes	No	0	3	7
45	R:R:L57	R:R:L61	24.5597	2.77	No	No	0	7	7
46	R:R:L61	R:R:T85	17.8063	1.47	No	No	0	7	5
47	R:R:F64	R:R:T85	14.4486	14.27	No	No	0	6	5
48	R:R:F64	R:R:V81	10.8502	3.93	No	No	0	6	6
49	R:R:A83	R:R:I145	10.4616	1.62	No	No	0	7	4
50	R:R:Y238	R:R:Y94	23.7319	7.94	Yes	Yes	1	7	8
51	R:R:L187	R:R:Y94	32.7195	8.21	No	Yes	0	6	8
52	R:R:H242	R:R:Y94	12.3833	4.36	Yes	Yes	1	6	8
53	R:R:N239	R:R:Y94	15.2004	11.63	No	Yes	0	8	8
54	R:R:L187	R:R:W98	24.7286	4.56	No	Yes	0	6	5
55	R:R:P191	R:R:W98	24.9314	14.86	Yes	Yes	1	9	5
56	R:R:F235	R:R:T97	19.4915	14.27	Yes	No	1	9	8
57	R:R:P191	R:R:T97	29.856	3.5	Yes	No	1	9	8
58	R:R:F231	R:R:F235	22.0383	5.36	Yes	Yes	1	9	9
59	R:R:H140	R:R:L187	11.8469	14.14	No	No	0	4	6
60	R:R:A101	R:R:P191	34.5948	1.87	No	Yes	0	8	9
61	R:R:A101	R:R:V194	32.4957	3.39	No	No	0	8	6
62	R:R:F231	R:R:T195	25.9112	9.08	Yes	No	0	9	7
63	R:R:S104	R:R:T195	24.6611	9.59	No	No	0	9	7
64	R:R:S104	R:R:Y199	23.8248	11.45	No	Yes	0	9	8
65	R:R:I105	R:R:V194	30.3881	3.07	No	No	0	6	6
66	R:R:C198	R:R:I105	28.2722	3.27	No	No	0	8	6
67	R:R:F273	R:R:R107	32.6731	8.55	Yes	No	1	9	9
68	R:R:C198	R:R:Y108	26.1477	5.38	No	Yes	0	8	8
69	R:R:A112	R:R:Y108	11.0402	5.34	No	Yes	0	7	8
70	R:R:R201	R:R:Y108	11.0402	6.17	Yes	Yes	0	4	8
71	R:R:R107	R:R:Y199	27.2332	11.32	No	Yes	1	9	8
72	R:R:A224	R:R:Y199	42.9193	2.67	No	Yes	0	7	8
73	R:R:A224	R:R:F202	31.6256	2.77	No	No	0	7	8
74	R:R:F202	R:R:V111	25.6071	7.87	No	No	4	8	8
75	R:R:I205	R:R:V111	23.8628	3.07	No	No	0	5	8
76	L:L:?1	R:R:Q148	10.7404	4.58	Yes	Yes	1	0	5
77	L:L:?1	R:R:R180	10.5926	15.32	Yes	Yes	1	0	5
78	R:R:R180	R:R:V176	10.4532	5.23	Yes	Yes	1	5	4
79	R:R:F168	R:R:R180	13.0802	3.21	Yes	Yes	1	4	5
80	R:R:F168	R:R:L173	11.2979	3.65	Yes	No	0	4	1
81	R:R:C184	R:R:N239	14.7949	4.72	No	No	0	6	8
82	R:R:C184	R:R:L243	15.3609	3.17	No	No	0	6	5
83	R:R:L181	R:R:L243	12.7719	4.15	No	No	0	5	5
84	R:R:F188	R:R:M192	11.3824	8.71	No	No	0	8	6
85	R:R:F231	R:R:M192	11.6104	4.98	Yes	No	0	9	6
86	R:R:A224	R:R:V203	10.3476	1.7	No	Yes	0	7	5
87	R:R:I205	R:R:Q209	21.8735	4.12	No	No	0	5	5
88	R:R:Q209	R:R:R217	17.8485	3.5	No	No	0	5	6
89	R:R:G213	R:R:R217	14.1276	3	No	No	0	3	6
90	R:R:G213	R:R:R218	12.0877	1.5	No	No	0	3	5
91	R:R:R216	R:R:R218	10.0393	9.6	No	No	0	5	5
92	R:R:P252	R:R:R255	21.768	5.76	Yes	Yes	1	1	5
93	R:R:P252	R:R:W254	17.1728	13.51	Yes	Yes	1	1	4
94	R:R:Y238	R:R:Y90	45.8166	13.9	Yes	Yes	1	7	5
95	R:R:L51	R:R:L99	10.3518	4.15	Yes	No	0	9	8
96	R:R:R255	R:R:Y238	18.8875	10.29	Yes	Yes	1	5	7
97	R:R:L100	R:R:N265	16.3365	5.49	Yes	Yes	1	8	9
98	R:R:F231	R:R:L100	14.1614	6.09	Yes	Yes	1	9	8
99	R:R:F231	R:R:T97	11.7118	3.89	Yes	No	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y90	20.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:C141	3.64	1	Yes	No	0	7	0	1
L:L:?1	R:R:V144	13.66	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I145	3.27	1	Yes	No	0	4	0	1
L:L:?1	R:R:Q148	4.58	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R180	15.32	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L183	6.35	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y238	12.09	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:H242	7.37	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R255	12.53	1	Yes	Yes	0	5	0	1
R:R:F89	R:R:K65	8.69	1	Yes	Yes	7	7	2	2
R:R:K65	R:R:Y90	8.36	1	Yes	Yes	7	5	2	1
R:R:K65	R:R:V259	4.55	1	Yes	Yes	7	5	2	2
R:R:S86	R:R:Y90	5.09	0	No	Yes	6	5	2	1
R:R:F87	R:R:S91	5.28	2	Yes	No	6	5	2	2
R:R:F87	R:R:I145	5.02	2	Yes	No	6	4	2	1
R:R:F89	R:R:Y90	6.19	1	Yes	Yes	7	5	2	1
R:R:F89	R:R:V259	3.93	1	Yes	Yes	7	5	2	2
R:R:Y238	R:R:Y90	13.9	1	Yes	Yes	7	5	1	1
R:R:R255	R:R:Y90	5.14	1	Yes	Yes	5	5	1	1
R:R:V259	R:R:Y90	3.79	1	Yes	Yes	5	5	2	1
R:R:C141	R:R:S91	3.44	0	No	No	7	5	1	2
R:R:I93	R:R:Y94	3.63	1	No	Yes	8	8	2	2
R:R:I93	R:R:Y238	6.04	1	No	Yes	8	7	2	1
R:R:I93	R:R:S262	9.29	1	No	No	8	8	2	2
R:R:L183	R:R:Y94	5.86	1	Yes	Yes	5	8	1	2
R:R:Y238	R:R:Y94	7.94	1	Yes	Yes	7	8	1	2
R:R:H242	R:R:Y94	4.36	1	Yes	Yes	6	8	1	2
R:R:Q148	R:R:V144	4.3	1	Yes	Yes	5	5	1	1
R:R:V144	R:R:V179	6.41	1	Yes	No	5	4	1	2
R:R:L183	R:R:V144	4.47	1	Yes	Yes	5	5	1	1
R:R:F168	R:R:Q148	9.37	1	Yes	Yes	4	5	2	1
R:R:Q148	R:R:V176	4.3	1	Yes	Yes	5	4	1	2
R:R:Q148	R:R:R180	4.67	1	Yes	Yes	5	5	1	1
R:R:F168	R:R:V176	3.93	1	Yes	Yes	4	4	2	2
R:R:F168	R:R:R180	3.21	1	Yes	Yes	4	5	2	1
R:R:R180	R:R:V176	5.23	1	Yes	Yes	5	4	1	2
R:R:H242	R:R:R180	10.16	1	Yes	Yes	6	5	1	1
R:R:R180	R:R:S251	3.95	1	Yes	No	5	4	1	2
R:R:R180	R:R:R255	19.19	1	Yes	Yes	5	5	1	1
R:R:H242	R:R:L183	3.86	1	Yes	Yes	6	5	1	1
R:R:H242	R:R:Y238	3.27	1	Yes	Yes	6	7	1	1
R:R:R255	R:R:Y238	10.29	1	Yes	Yes	5	7	1	1
R:R:S262	R:R:Y238	7.63	1	No	Yes	8	7	2	1
R:R:H242	R:R:R255	4.51	1	Yes	Yes	6	5	1	1
R:R:P252	R:R:R255	5.76	1	Yes	Yes	1	5	2	1
R:R:A83	R:R:I145	1.62	0	No	No	7	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8T3S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	248
Number of Links	301
Number of Hubs	45
Number of Links mediated by Hubs	162
Number of Communities	5
Number of Nodes involved in Communities	73
Number of Links involved in Communities	117

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	59371
Length Of Smallest Path	3
Average Path Length	12.7593
Length of Longest Path	30
Minimum Path Strength	1.305
Average Path Strength	6.31798
Maximum Path Strength	19.71
Minimum Path Correlation	0.7
Average Path Correlation	0.918092
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.0069
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.7675
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of response to biotic stimulus • immune response-regulating cell surface receptor signaling pathway • regulation of cellular process • response to stimulus • pattern recognition receptor signaling pathway • response to biotic stimulus • cell communication • immune response-activating signaling pathway • positive regulation of immune response • regulation of immune system process • signal transduction • positive regulation of immune system process • innate immune response-activating signaling pathway • regulation of biological process • immune response • response to other organism • immune response-activating cell surface receptor signaling pathway • regulation of innate immune response • response to external stimulus • regulation of response to stimulus • defense response to other organism • positive regulation of defense response • activation of innate immune response • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of response to external stimulus • signaling • positive regulation of biological process • innate immune response activating cell surface receptor signaling pathway • positive regulation of response to stimulus • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of response to stress • response to stress • innate immune response • response to external biotic stimulus • cell surface pattern recognition receptor signaling pathway • positive regulation of innate immune response • cell surface receptor signaling pathway • defense response • biological regulation • defense response to symbiont • immune system process • cellular process • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • localization • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • regulation of cell communication • hormone transport • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • macromolecule localization • insulin secretion • multicellular organismal process • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of biosynthetic process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of interleukin-8 production • regulation of chemokine production • chemokine production • positive regulation of chemokine production • cell chemotaxis • leukocyte chemotaxis involved in inflammatory response • chemotaxis • leukocyte migration involved in inflammatory response • leukocyte migration • cellular response to chemical stimulus • taxis • response to chemical • cell migration • inflammatory response • cell motility • leukocyte chemotaxis • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • developmental process • fat cell differentiation • cellular developmental process • cell differentiation • mucosal immune response • organ or tissue specific immune response • lipid storage • nutrient storage • positive regulation of acute inflammatory response • positive regulation of inflammatory response • regulation of acute inflammatory response to non-antigenic stimulus • acute inflammatory response • acute inflammatory response to non-antigenic stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response to non-antigenic stimulus • regulation of acute inflammatory response • response to lipid • response to fatty acid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to fatty acid • cellular response to lipid • positive regulation of cell communication • positive regulation of establishment of protein localization • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • positive regulation of protein localization • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of signaling • regulation of immune effector process • positive regulation of immune effector process • cytokine production involved in immune response • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune effector process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BUA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	BUA
Name	Butyric Acid
Synonyms	α-keto-γ-methylselenobutyrate
Identifier
Formula	C4 H8 O2
Molecular Weight	88.105
SMILES
PubChem	264
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	13
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O15552
Sequence	>8T3S_nogp_Chain_R P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q P Q P A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S N L P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F P V Q Y K L S R R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L C Y E N F T D N Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q P G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R K S P W W R S I A V V F S S L N A S L D P L L F Y F S S S V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J22	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-	Gi1/β1/γ2	3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J22 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	-		3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-	Gi1/β1/γ2	2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J24 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Acetic acid	-		2.6	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8T3S	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3S (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.07	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8J23	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-04-17	To be published
	8J23 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	-	-		3.2	2024-04-17	To be published
	9K1D	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-	Gi1/β1/γ2	3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1D (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	Butyric acid	-		3.34	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8Y6W	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	Gi1/β1/γ2	3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6W (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	8Y6Y	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	GLPG0974	-	-	3.36	2025-04-02	doi.org/10.1038/s41467-025-57983-4
	9CLW	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CLW (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	4-CMTB		3.19	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729	Gi1/β1/γ2	3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM7 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	AZ-1729		3.29	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810	Gi1/β1/γ2	3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9NS9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	PubChem 118615810		3.3	2025-06-25	doi.org/10.1038/s41586-025-09186-6

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