psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D114	7.73	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y115	8.59	Yes	Yes	1	0	9
3	L:L:?1	R:R:C118	9.04	Yes	No	0	0	8
4	L:L:?1	R:R:E206	12.95	Yes	Yes	0	0	8
5	L:L:?1	R:R:Y374	19.09	Yes	Yes	1	0	9
6	L:L:?1	R:R:F398	20.82	Yes	Yes	1	0	7
7	L:L:?1	R:R:L401	14.65	Yes	No	1	0	8
8	L:L:?1	R:R:W402	11.13	Yes	Yes	1	0	8
9	R:R:M41	R:R:V92	4.56	No	No	0	7	7
10	R:R:M41	R:R:W399	9.31	No	No	0	7	9
11	R:R:I45	R:R:I88	4.42	No	No	0	7	9
12	R:R:I45	R:R:P89	5.08	No	No	0	7	9
13	R:R:F81	R:R:V49	5.24	No	No	0	8	7
14	R:R:D80	R:R:N52	6.73	Yes	No	0	9	9
15	R:R:N52	R:R:P409	13.03	No	No	0	9	9
16	R:R:A77	R:R:V55	5.09	No	No	0	9	9
17	R:R:P413	R:R:V55	7.07	No	No	0	9	9
18	R:R:I78	R:R:M56	4.37	No	No	0	8	7
19	R:R:F81	R:R:M56	12.44	No	No	0	8	7
20	R:R:F59	R:R:R66	14.97	No	No	0	8	8
21	R:R:F59	R:R:F71	12.86	No	Yes	0	8	6
22	R:R:F59	R:R:L74	19.49	No	No	0	8	8
23	R:R:A61	R:R:L426	4.73	No	Yes	0	7	8
24	R:R:D62	R:R:S64	10.31	Yes	No	3	8	7
25	R:R:D62	R:R:L65	10.86	Yes	No	0	8	9
26	R:R:D62	R:R:R421	5.96	Yes	No	3	8	6
27	R:R:R421	R:R:S64	5.27	No	No	3	6	7
28	R:R:L65	R:R:N70	4.12	No	Yes	0	9	9
29	R:R:N70	R:R:T67	10.24	Yes	No	0	9	8
30	R:R:Q146	R:R:T67	8.5	No	No	0	8	8
31	R:R:Q68	R:R:R151	7.01	No	No	0	8	7
32	R:R:K155	R:R:Q68	4.07	Yes	No	0	7	8
33	R:R:L73	R:R:N69	5.49	Yes	No	0	8	8
34	R:R:D131	R:R:N69	8.08	No	No	0	9	8
35	R:R:H416	R:R:N69	7.65	Yes	No	0	9	8
36	R:R:H416	R:R:N70	5.1	Yes	Yes	4	9	9
37	R:R:F419	R:R:N70	8.46	Yes	Yes	4	9	9
38	R:R:F71	R:R:T149	5.19	Yes	No	0	6	6
39	R:R:A152	R:R:F71	4.16	No	Yes	0	8	6
40	R:R:F72	R:R:L127	19.49	No	No	5	9	8
41	R:R:D131	R:R:F72	7.17	No	No	0	9	9
42	R:R:F72	R:R:K155	7.44	No	Yes	5	9	7
43	R:R:I128	R:R:L73	4.28	No	Yes	0	9	8
44	R:R:L73	R:R:P413	6.57	Yes	No	0	8	9
45	R:R:F419	R:R:L73	6.09	Yes	Yes	0	9	8
46	R:R:I78	R:R:L74	7.14	No	No	0	8	8
47	R:R:N124	R:R:N75	16.35	No	No	0	8	9
48	R:R:M156	R:R:N75	9.82	No	No	0	9	9
49	R:R:N75	R:R:W160	11.3	No	No	0	9	9
50	R:R:D80	R:R:L76	5.43	Yes	Yes	2	9	9
51	R:R:L76	R:R:N124	9.61	Yes	No	0	9	8
52	R:R:L76	R:R:N408	10.98	Yes	Yes	2	9	9
53	R:R:L76	R:R:Y412	4.69	Yes	Yes	0	9	9
54	R:R:S120	R:R:S79	6.52	No	No	0	8	8
55	R:R:D80	R:R:S121	7.36	Yes	No	0	9	9
56	R:R:D80	R:R:S405	8.83	Yes	No	0	9	9
57	R:R:D80	R:R:N408	8.08	Yes	Yes	2	9	9
58	R:R:A85	R:R:F81	4.16	No	No	0	6	8
59	R:R:L117	R:R:L82	6.92	No	No	0	7	6
60	R:R:L117	R:R:V83	4.47	No	No	0	7	9
61	R:R:S405	R:R:V83	8.08	No	No	0	9	9
62	R:R:G84	R:R:I88	5.29	No	No	0	9	9
63	R:R:F86	R:R:L90	8.53	No	No	0	6	6
64	R:R:F86	R:R:V113	6.55	No	No	0	6	6
65	R:R:C87	R:R:D114	6.22	No	Yes	0	9	9
66	R:R:I88	R:R:W402	15.27	No	Yes	0	9	8
67	R:R:Y91	R:R:Y94	14.89	Yes	No	0	8	6
68	R:R:W110	R:R:Y91	10.61	Yes	Yes	0	6	8
69	R:R:E395	R:R:Y91	5.61	No	Yes	0	6	8
70	R:R:F398	R:R:Y91	11.35	Yes	Yes	1	7	8
71	R:R:W402	R:R:Y91	7.72	Yes	Yes	1	8	8
72	R:R:L96	R:R:V92	4.47	No	No	0	7	7
73	R:R:F102	R:R:P93	4.33	Yes	No	0	8	7
74	R:R:W100	R:R:Y94	5.79	Yes	No	0	9	6
75	R:R:H187	R:R:Y94	4.36	No	No	0	3	6
76	R:R:G186	R:R:R99	4.5	No	No	0	3	4
77	R:R:F102	R:R:W100	10.02	Yes	Yes	0	8	9
78	R:R:C107	R:R:W100	5.22	No	Yes	6	9	9
79	R:R:W100	R:R:W110	6.56	Yes	Yes	0	9	6
80	R:R:C188	R:R:W100	16.98	No	Yes	6	9	9
81	R:R:F102	R:R:L106	6.09	Yes	No	0	8	5
82	R:R:K108	R:R:R104	17.33	No	No	0	7	4
83	R:R:E175	R:R:R104	4.65	No	No	0	5	4
84	R:R:C107	R:R:C188	7.28	No	No	6	9	9
85	R:R:K108	R:R:L172	4.23	No	No	0	7	5
86	R:R:L111	R:R:W110	5.69	No	Yes	0	7	6
87	R:R:D114	R:R:W110	10.05	Yes	Yes	0	9	6
88	R:R:I171	R:R:L111	4.28	No	No	0	7	7
89	R:R:L172	R:R:V112	4.47	No	No	0	5	8
90	R:R:D114	R:R:W402	11.17	Yes	Yes	1	9	8
91	R:R:Y115	R:R:Y167	15.89	Yes	Yes	1	9	8
92	R:R:I171	R:R:Y115	6.04	No	Yes	0	7	9
93	R:R:F192	R:R:Y115	7.22	Yes	Yes	1	7	9
94	R:R:F123	R:R:T119	5.19	No	No	0	7	9
95	R:R:E206	R:R:T119	8.47	Yes	No	0	8	9
96	R:R:S120	R:R:W160	9.88	No	No	0	8	9
97	R:R:A122	R:R:W371	5.19	No	Yes	0	9	8
98	R:R:N124	R:R:V159	7.39	No	No	0	8	8
99	R:R:I125	R:R:N408	5.66	No	Yes	0	8	9
100	R:R:I125	R:R:Y412	10.88	No	Yes	0	8	9
101	R:R:K155	R:R:L127	4.23	Yes	No	5	7	8
102	R:R:I128	R:R:Y412	7.25	No	Yes	0	9	9
103	R:R:S129	R:R:V214	6.46	No	No	0	9	9
104	R:R:N218	R:R:S129	5.96	No	No	0	9	9
105	R:R:L134	R:R:Y130	12.89	No	No	0	5	7
106	R:R:F217	R:R:Y130	10.32	Yes	No	0	8	7
107	R:R:D131	R:R:Y142	10.34	No	No	0	9	9
108	R:R:R132	R:R:Y412	4.12	No	Yes	0	9	9
109	R:R:F133	R:R:T137	15.56	No	No	0	9	8
110	R:R:F133	R:R:F217	10.72	No	Yes	0	9	8
111	R:R:S135	R:R:Y142	8.9	No	No	0	9	9
112	R:R:N224	R:R:V136	4.43	No	No	0	7	8
113	R:R:Q145	R:R:S141	8.66	No	No	0	6	5
114	R:R:Q146	R:R:Y142	4.51	No	No	0	8	9
115	R:R:Q145	R:R:R151	11.68	No	No	0	6	7
116	R:R:D148	R:R:R151	13.1	No	No	0	8	7
117	R:R:L158	R:R:R154	4.86	No	No	0	4	3
118	R:R:L158	R:R:L162	5.54	No	No	0	4	6
119	R:R:F164	R:R:G168	4.52	Yes	No	0	7	6
120	R:R:F164	R:R:P169	4.33	Yes	No	0	7	8
121	R:R:F192	R:R:Y167	4.13	Yes	Yes	1	7	8
122	R:R:F198	R:R:Y167	4.13	Yes	Yes	1	7	8
123	R:R:E206	R:R:Y167	15.71	Yes	Yes	0	8	8
124	R:R:A170	R:R:F198	4.16	No	Yes	0	8	7
125	R:R:S178	R:R:W174	6.18	No	No	0	3	5
126	R:R:E191	R:R:W174	13.08	No	No	0	8	5
127	R:R:N195	R:R:W174	6.78	No	No	0	6	5
128	R:R:E175	R:R:S181	8.62	No	No	0	5	4
129	R:R:E175	R:R:E191	7.61	No	No	0	5	8
130	R:R:I183	R:R:Y189	6.04	No	No	0	4	4
131	R:R:E191	R:R:I183	4.1	No	No	0	8	4
132	R:R:H187	R:R:P184	4.58	No	No	0	3	3
133	R:R:P184	R:R:Y189	4.17	No	No	0	3	4
134	R:R:F193	R:R:Y189	14.44	Yes	No	0	5	4
135	R:R:A190	R:R:F192	8.32	No	Yes	0	7	7
136	R:R:F192	R:R:F198	18.22	Yes	Yes	1	7	7
137	R:R:F193	R:R:Y194	13.41	Yes	No	1	5	6
138	R:R:F193	R:R:M378	4.98	Yes	No	1	5	8
139	R:R:F193	R:R:R381	18.17	Yes	Yes	1	5	4
140	R:R:F193	R:R:Y394	8.25	Yes	Yes	1	5	4
141	R:R:R381	R:R:Y194	7.2	Yes	No	1	4	6
142	R:R:F198	R:R:N195	4.83	Yes	No	0	7	6
143	R:R:W196	R:R:Y197	11.58	No	No	0	5	5
144	R:R:A202	R:R:F198	4.16	No	Yes	0	9	7
145	R:R:I200	R:R:I379	4.42	No	No	0	7	6
146	R:R:F208	R:R:T204	5.19	Yes	No	0	7	6
147	R:R:E206	R:R:W371	7.63	Yes	Yes	0	8	8
148	R:R:F207	R:R:F208	6.43	Yes	Yes	0	9	7
149	R:R:F207	R:R:F211	8.57	Yes	Yes	1	9	8
150	R:R:F207	R:R:F367	5.36	Yes	No	1	9	9
151	R:R:F207	R:R:W371	9.02	Yes	Yes	1	9	8
152	R:R:F207	R:R:T375	7.78	Yes	No	0	9	8
153	R:R:F211	R:R:T215	6.49	Yes	No	0	8	6
154	R:R:F211	R:R:F367	4.29	Yes	No	1	8	9
155	R:R:F211	R:R:G368	4.52	Yes	No	0	8	7
156	R:R:F216	R:R:F217	6.43	No	Yes	0	5	8
157	R:R:F216	R:R:S220	7.93	No	No	0	5	8
158	R:R:L360	R:R:N218	5.49	No	No	0	8	9
159	R:R:N218	R:R:V364	4.43	No	No	0	9	8
160	R:R:Q226	R:R:Y222	16.91	No	No	0	7	7
161	R:R:N224	R:R:R227	8.44	No	No	0	7	5
162	R:R:D353	R:R:I225	5.6	No	No	0	9	8
163	R:R:R349	R:R:T229	12.94	Yes	No	0	6	6
164	R:R:D353	R:R:T229	8.67	No	No	0	9	6
165	R:R:A236	R:R:R232	5.53	No	No	0	3	5
166	R:R:R232	R:R:R349	10.66	No	Yes	0	5	6
167	R:R:L233	R:R:Q346	6.65	No	No	0	5	5
168	R:R:D234	R:R:G235	6.71	No	No	0	4	4
169	R:R:L350	R:R:R347	6.07	No	No	0	6	5
170	R:R:I363	R:R:Y412	6.04	No	Yes	0	8	9
171	R:R:I366	R:R:L411	4.28	No	No	0	7	9
172	R:R:F367	R:R:W371	8.02	No	Yes	1	9	8
173	R:R:C370	R:R:N404	11.02	No	No	0	8	9
174	R:R:L401	R:R:W371	15.94	No	Yes	1	8	8
175	R:R:N404	R:R:W371	7.91	No	Yes	0	9	8
176	R:R:M378	R:R:Y374	16.76	No	Yes	1	8	9
177	R:R:Y374	R:R:Y394	4.96	Yes	Yes	1	9	4
178	R:R:S397	R:R:Y374	6.36	No	Yes	0	7	9
179	R:R:F398	R:R:Y374	9.28	Yes	Yes	1	7	9
180	R:R:L401	R:R:Y374	4.69	No	Yes	1	8	9
181	R:R:L377	R:R:S397	6.01	No	No	0	7	7
182	R:R:M378	R:R:R381	7.44	No	Yes	1	8	4
183	R:R:R381	R:R:V389	5.23	Yes	No	0	4	5
184	R:R:C384	R:R:C388	7.28	No	No	0	7	8
185	R:R:P390	R:R:Y392	12.52	No	No	7	7	3
186	R:R:P390	R:R:W393	14.86	No	No	7	7	6
187	R:R:W393	R:R:Y392	7.72	No	No	7	6	3
188	R:R:E395	R:R:Y394	6.73	No	Yes	0	6	4
189	R:R:F398	R:R:Y394	5.16	Yes	Yes	1	7	4
190	R:R:F398	R:R:W402	9.02	Yes	Yes	1	7	8
191	R:R:W399	R:R:W402	11.25	No	Yes	0	9	8
192	R:R:N404	R:R:N408	6.81	No	Yes	0	9	9
193	R:R:L411	R:R:V407	4.47	No	No	0	9	7
194	R:R:L411	R:R:Y412	4.69	No	Yes	0	9	9
195	R:R:H416	R:R:S418	5.58	Yes	No	0	9	8
196	R:R:F419	R:R:H416	6.79	Yes	Yes	4	9	9
197	R:R:F348	R:R:S351	3.96	No	No	0	4	6
198	R:R:R138	R:R:T137	3.88	No	No	0	6	8
199	R:R:V95	R:R:Y91	3.79	No	Yes	0	6	8
200	R:R:F71	R:R:M156	3.73	Yes	No	0	6	9
201	R:R:F123	R:R:L166	3.65	No	No	0	7	8
202	R:R:G84	R:R:T48	3.64	No	No	0	9	9
203	R:R:G98	R:R:T97	3.64	No	No	0	7	5
204	R:R:K108	R:R:Y176	3.58	No	No	0	7	5
205	R:R:P210	R:R:V126	3.53	No	No	0	9	8
206	R:R:P390	R:R:V389	3.53	No	No	0	7	5
207	R:R:P210	R:R:T209	3.5	No	No	0	9	7
208	R:R:L90	R:R:W110	3.42	No	Yes	0	6	6
209	R:R:L116	R:R:W160	3.42	No	No	0	8	9
210	R:R:A163	R:R:T119	3.36	No	No	0	8	9
211	R:R:L400	R:R:P373	3.28	No	No	0	9	9
212	R:R:F419	R:R:F423	3.22	Yes	No	0	9	9
213	R:R:S203	R:R:T375	3.2	No	No	0	8	8
214	R:R:R227	R:R:R228	3.2	No	No	0	5	8
215	R:R:R228	R:R:R349	3.2	No	Yes	0	8	6
216	R:R:S343	R:R:T345	3.2	No	No	0	3	7
217	R:R:T215	R:R:V364	3.17	No	No	0	6	8
218	R:R:A422	R:R:D62	3.09	No	Yes	0	9	8
219	R:R:I221	R:R:V136	3.07	No	No	0	9	8
220	R:R:I225	R:R:V356	3.07	No	No	0	8	8
221	R:R:G386	R:R:R381	3	No	Yes	0	3	4
222	R:R:L50	R:R:V49	2.98	No	No	0	5	7
223	R:R:L157	R:R:V153	2.98	No	No	0	5	5
224	R:R:L360	R:R:V356	2.98	No	No	0	8	8
225	R:R:L44	R:R:T48	2.95	No	No	0	7	9
226	R:R:G103	R:R:W100	2.81	No	Yes	0	8	9
227	R:R:A58	R:R:F423	2.77	No	No	0	9	9
228	R:R:L106	R:R:L109	2.77	No	No	0	5	6
229	R:R:A372	R:R:F207	2.77	No	Yes	0	7	9
230	R:R:A357	R:R:Y222	2.67	No	No	0	8	7
231	R:R:F217	R:R:S129	2.64	Yes	No	0	8	9
232	R:R:F164	R:R:V112	2.62	Yes	No	0	7	8
233	R:R:F102	R:R:T101	2.59	Yes	No	0	8	5
234	R:R:A382	R:R:W196	2.59	No	No	0	7	5
235	R:R:A383	R:R:W196	2.59	No	No	0	5	5
236	R:R:F208	R:R:I379	2.51	Yes	No	0	7	6
237	R:R:K155	R:R:R154	2.48	Yes	No	0	7	3
238	R:R:K355	R:R:R352	2.48	No	No	0	8	8
239	R:R:F164	R:R:L165	2.44	Yes	No	0	7	5
240	R:R:F192	R:R:L199	2.44	Yes	No	0	7	8
241	R:R:L414	R:R:R420	2.43	No	No	0	7	9
242	R:R:D148	R:R:R150	2.38	No	No	0	8	7
243	R:R:L223	R:R:Y222	2.34	No	No	0	5	7
244	R:R:N195	R:R:Y197	2.33	No	No	0	6	5
245	R:R:H417	R:R:R420	2.26	No	No	0	5	9
246	R:R:R227	R:R:R230	2.13	No	No	0	5	6
247	R:R:R349	R:R:R352	2.13	Yes	No	0	6	8
248	R:R:G179	R:R:G180	2.11	No	No	0	5	2
249	R:R:C384	R:R:G386	1.96	No	No	0	7	3
250	R:R:A372	R:R:P373	1.87	No	No	0	7	9
251	R:R:A35	R:R:T34	1.68	No	No	0	5	5
252	R:R:A406	R:R:T48	1.68	No	No	0	7	9
253	R:R:G147	R:R:Q146	1.64	No	No	0	6	8
254	R:R:E185	R:R:G186	1.64	No	No	0	1	3
255	R:R:C388	R:R:I380	1.64	No	No	0	8	7
256	R:R:S213	R:R:V126	1.62	No	No	0	8	8
257	R:R:A53	R:R:M56	1.61	No	No	0	6	7
258	R:R:V126	R:R:V214	1.6	No	No	0	8	9
259	R:R:A58	R:R:L426	1.58	No	Yes	0	9	8
260	R:R:I363	R:R:S359	1.55	No	No	0	8	9
261	R:R:I366	R:R:V362	1.54	No	No	0	7	8
262	R:R:I200	R:R:T201	1.52	No	No	0	7	6
263	R:R:A236	R:R:Q346	1.52	No	No	0	3	5
264	R:R:G105	R:R:R104	1.5	No	No	0	5	4
265	R:R:L50	R:R:V46	1.49	No	No	0	5	5
266	R:R:L165	R:R:V161	1.49	No	No	0	5	5
267	R:R:L414	R:R:V410	1.49	No	No	0	7	7
268	R:R:D62	R:R:S63	1.47	Yes	No	0	8	8
269	R:R:L350	R:R:T229	1.47	No	No	0	6	6
270	R:R:Q346	R:R:T345	1.42	No	No	0	5	7
271	R:R:H417	R:R:S418	1.39	No	No	0	5	8
272	R:R:L426	R:R:L57	1.38	Yes	No	0	8	7
273	R:R:L166	R:R:L205	1.38	No	No	0	8	6
274	R:R:L219	R:R:L223	1.38	No	No	0	4	5
275	R:R:L426	R:R:L427	1.38	Yes	No	0	8	8
276	R:R:D353	R:R:Q226	1.31	No	No	0	9	7
277	R:R:F423	R:R:L54	1.22	No	No	0	9	8
278	R:R:F208	R:R:L376	1.22	Yes	No	0	7	7
279	R:R:F211	R:R:L212	1.22	Yes	No	0	8	5
280	R:R:H385	R:R:Y194	1.09	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	13	8	1	0
2	R:R:D62	6.338	5	3	8
3	R:R:N70	6.98	4	4	9
4	R:R:F71	6.485	4	0	6
5	R:R:L73	5.6075	4	0	8
6	R:R:L76	7.6775	4	2	9
7	R:R:D80	7.286	5	2	9
8	R:R:Y91	8.995	6	1	8
9	R:R:W100	7.89667	6	6	9
10	R:R:F102	5.7575	4	0	8
11	R:R:W110	7.266	5	0	6
12	R:R:D114	8.7925	4	1	9
13	R:R:Y115	9.435	4	1	9
14	R:R:K155	4.555	4	5	7
15	R:R:F164	3.4775	4	0	7
16	R:R:Y167	9.965	4	1	8
17	R:R:F192	8.066	5	1	7
18	R:R:F193	11.85	5	1	5
19	R:R:F198	7.1	5	1	7
20	R:R:E206	11.19	4	0	8
21	R:R:F207	6.655	6	1	9
22	R:R:F208	3.8375	4	0	7
23	R:R:F211	5.018	5	1	8
24	R:R:F217	7.5275	4	0	8
25	R:R:R349	7.2325	4	0	6
26	R:R:W371	8.95167	6	1	8
27	R:R:Y374	10.19	6	1	9
28	R:R:R381	8.208	5	1	4
29	R:R:Y394	6.275	4	1	4
30	R:R:F398	11.126	5	1	7
31	R:R:W402	10.9267	6	1	8
32	R:R:N408	7.8825	4	2	9
33	R:R:Y412	6.27833	6	0	9
34	R:R:H416	6.28	4	4	9
35	R:R:F419	6.14	4	4	9
36	R:R:L426	2.2675	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W402	22.395	11.13	Yes	Yes	1	0	8
2	R:R:I88	R:R:W402	11.4383	15.27	No	Yes	0	9	8
3	L:L:?1	R:R:E206	29.3264	12.95	Yes	Yes	0	0	8
4	R:R:E206	R:R:W371	50.2648	7.63	Yes	Yes	0	8	8
5	R:R:N404	R:R:W371	100	7.91	No	Yes	0	9	8
6	R:R:N404	R:R:N408	99.4703	6.81	No	Yes	0	9	9
7	R:R:L76	R:R:N408	54.1699	10.98	Yes	Yes	2	9	9
8	R:R:L76	R:R:N124	18.0061	9.61	Yes	No	0	9	8
9	R:R:N124	R:R:N75	16.4652	16.35	No	No	0	8	9
10	R:R:M156	R:R:N75	12.5289	9.82	No	No	0	9	9
11	R:R:F71	R:R:M156	11.7272	3.73	Yes	No	0	6	9
12	L:L:?1	R:R:L401	26.8779	14.65	Yes	No	1	0	8
13	R:R:L401	R:R:W371	49.0177	15.94	No	Yes	1	8	8
14	R:R:L76	R:R:Y412	43.8824	4.69	Yes	Yes	0	9	9
15	R:R:I128	R:R:Y412	73.4953	7.25	No	Yes	0	9	9
16	R:R:I128	R:R:L73	72.2337	4.28	No	Yes	0	9	8
17	R:R:I125	R:R:N408	39.9942	5.66	No	Yes	0	8	9
18	R:R:I125	R:R:Y412	39.4766	10.88	No	Yes	0	8	9
19	R:R:F419	R:R:L73	33.8766	6.09	Yes	Yes	0	9	8
20	R:R:F419	R:R:F423	10.6486	3.22	Yes	No	0	9	9
21	R:R:F419	R:R:N70	14.2166	8.46	Yes	Yes	4	9	9
22	R:R:L73	R:R:N69	33.8766	5.49	Yes	No	0	8	8
23	R:R:D131	R:R:N69	24.8315	8.08	No	No	0	9	8
24	R:R:D131	R:R:F72	17.8231	7.17	No	No	0	9	9
25	R:R:F72	R:R:K155	14.8763	7.44	No	Yes	5	9	7
26	L:L:?1	R:R:D114	22.8019	7.73	Yes	Yes	1	0	9
27	R:R:D114	R:R:W110	20.0308	10.05	Yes	Yes	0	9	6
28	R:R:F398	R:R:Y91	10.0226	11.35	Yes	Yes	1	7	8
29	R:R:W100	R:R:W110	14.8425	6.56	Yes	Yes	0	9	6
30	R:R:F198	R:R:Y167	18.7813	4.13	Yes	Yes	1	7	8
31	R:R:F198	R:R:N195	17.3055	4.83	Yes	No	0	7	6
32	R:R:N195	R:R:W174	12.2833	6.78	No	No	0	6	5
33	R:R:E191	R:R:W174	10.7738	13.08	No	No	0	8	5
34	R:R:E175	R:R:E191	12.1437	7.61	No	No	0	5	8
35	R:R:E175	R:R:R104	10.3501	4.65	No	No	0	5	4
36	R:R:E206	R:R:Y167	21.6078	15.71	Yes	Yes	0	8	8
37	R:R:M378	R:R:Y374	14.5922	16.76	No	Yes	1	8	9
38	R:R:F207	R:R:W371	44.4361	9.02	Yes	Yes	1	9	8
39	R:R:F207	R:R:F211	36.7537	8.57	Yes	Yes	1	9	8
40	R:R:F211	R:R:T215	67.9459	6.49	Yes	No	0	8	6
41	R:R:T215	R:R:V364	66.4941	3.17	No	No	0	6	8
42	R:R:N218	R:R:V364	65.0376	4.43	No	No	0	9	8
43	R:R:N218	R:R:S129	22.7826	5.96	No	No	0	9	9
44	R:R:F367	R:R:W371	36.1614	8.02	No	Yes	1	9	8
45	R:R:F211	R:R:F367	35.5162	4.29	Yes	No	1	8	9
46	R:R:F217	R:R:S129	13.1332	2.64	Yes	No	0	8	9
47	R:R:L360	R:R:N218	42.6112	5.49	No	No	0	8	9
48	R:R:L360	R:R:V356	41.0728	2.98	No	No	0	8	8
49	R:R:I225	R:R:V356	39.6933	3.07	No	No	0	8	8
50	R:R:D353	R:R:I225	38.3089	5.6	No	No	0	9	8
51	R:R:D353	R:R:T229	28.946	8.67	No	No	0	9	6
52	R:R:R349	R:R:T229	24.2007	12.94	Yes	No	0	6	6
53	R:R:H416	R:R:S418	14.4068	5.58	Yes	No	0	9	8
54	R:R:H417	R:R:S418	11.5346	1.39	No	No	0	5	8
55	R:R:L401	R:R:Y374	21.8052	4.69	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D114	7.73	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y115	8.59	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:C118	9.04	1	Yes	No	0	8	0	1
L:L:?1	R:R:E206	12.95	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y374	19.09	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F398	20.82	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L401	14.65	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	11.13	1	Yes	Yes	0	8	0	1
R:R:C87	R:R:D114	6.22	0	No	Yes	9	9	2	1
R:R:I88	R:R:W402	15.27	0	No	Yes	9	8	2	1
R:R:W110	R:R:Y91	10.61	0	Yes	Yes	6	8	2	2
R:R:F398	R:R:Y91	11.35	1	Yes	Yes	7	8	1	2
R:R:W402	R:R:Y91	7.72	1	Yes	Yes	8	8	1	2
R:R:D114	R:R:W110	10.05	1	Yes	Yes	9	6	1	2
R:R:D114	R:R:W402	11.17	1	Yes	Yes	9	8	1	1
R:R:Y115	R:R:Y167	15.89	1	Yes	Yes	9	8	1	2
R:R:I171	R:R:Y115	6.04	0	No	Yes	7	9	2	1
R:R:F192	R:R:Y115	7.22	1	Yes	Yes	7	9	2	1
R:R:E206	R:R:T119	8.47	0	Yes	No	8	9	1	2
R:R:F192	R:R:Y167	4.13	1	Yes	Yes	7	8	2	2
R:R:E206	R:R:Y167	15.71	0	Yes	Yes	8	8	1	2
R:R:E206	R:R:W371	7.63	0	Yes	Yes	8	8	1	2
R:R:L401	R:R:W371	15.94	1	No	Yes	8	8	1	2
R:R:M378	R:R:Y374	16.76	1	No	Yes	8	9	2	1
R:R:Y374	R:R:Y394	4.96	1	Yes	Yes	9	4	1	2
R:R:S397	R:R:Y374	6.36	0	No	Yes	7	9	2	1
R:R:F398	R:R:Y374	9.28	1	Yes	Yes	7	9	1	1
R:R:L401	R:R:Y374	4.69	1	No	Yes	8	9	1	1
R:R:F398	R:R:Y394	5.16	1	Yes	Yes	7	4	1	2
R:R:F398	R:R:W402	9.02	1	Yes	Yes	7	8	1	1
R:R:W399	R:R:W402	11.25	0	No	Yes	9	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YN6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.06
Number of Linked Nodes	258
Number of Links	280
Number of Hubs	36
Number of Links mediated by Hubs	134
Number of Communities	7
Number of Nodes involved in Communities	38
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	72936
Length Of Smallest Path	3
Average Path Length	14.9101
Length of Longest Path	32
Minimum Path Strength	1.38
Average Path Strength	7.48588
Maximum Path Strength	17.925
Minimum Path Correlation	0.7
Average Path Correlation	0.930912
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	50.0546
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.1981
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cellular localization • neurotransmitter secretion • transport • secretion • export from cell • neurotransmitter transport • establishment of localization • localization • signal release from synapse • secretion by cell • signal release • establishment of localization in cell • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • presynapse • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ITF
Name	2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate
Synonyms
Identifier
Formula	C6 H10 N4 S
Molecular Weight	170.235
SMILES
PubChem	3692
Formal Charge	0
Total Atoms	21
Total Chiral Atoms	0
Total Bonds	21
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5N1
Sequence	>8YN6_nogp_Chain_R T A V L A A L M A L L I V A T V L G N A L V M L A F V A D S S L R T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R W T F G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R A V S Y R A Q Q G D T R R A V R K M L L V W V L A F L L Y G P A I L S W E Y L S G G S S I P E G H C Y A E F F Y N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G A S F T Q R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C H G H C V P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F R R A F T K L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ	2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YN8	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-	Go1/β1/γ2	2.77	2024-10-16	10.2210/pdb8YN7/pdb
	8YN8 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-		2.77	2024-10-16	10.2210/pdb8YN7/pdb
	8YN7	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-	Go1/β1/γ2	2.77	2024-10-16	10.2210/pdb8YN7/pdb
	8YN7 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-		2.77	2024-10-16	10.2210/pdb8YN7/pdb
	8YN6	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-	Gi1/β1/γ2	2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-		2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YUU	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ1	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUU (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8TH3	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	AT118-H Nanobody	-	3	2024-05-22	10.1038/s41589-024-01620-6
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	10.1126/sciadv.adk4855
	8YUV	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-	Gi1/β1/γ2	3	2024-06-05	10.1002/advs.202310120
	8YUV (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-		3	2024-06-05	10.1002/advs.202310120
	7F61	A	Amine	Histamine	H₃	Homo sapiens	PF-03654746	Cholesterol	-	2.6	2022-10-26	10.1038/s41467-022-33880-y

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