psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D114	7.73	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y115	8.59	Yes	Yes	1	0	9
3	L:L:?1	R:R:C118	9.04	Yes	No	0	0	8
4	L:L:?1	R:R:E206	12.95	Yes	Yes	0	0	8
5	L:L:?1	R:R:Y374	19.09	Yes	Yes	1	0	9
6	L:L:?1	R:R:F398	20.82	Yes	Yes	1	0	7
7	L:L:?1	R:R:L401	14.65	Yes	No	1	0	8
8	L:L:?1	R:R:W402	11.13	Yes	Yes	1	0	8
9	R:R:M41	R:R:V92	4.56	No	No	0	7	7
10	R:R:M41	R:R:W399	9.31	No	No	0	7	9
11	R:R:I45	R:R:I88	4.42	No	No	0	7	9
12	R:R:I45	R:R:P89	5.08	No	No	0	7	9
13	R:R:F81	R:R:V49	5.24	No	No	0	8	7
14	R:R:D80	R:R:N52	6.73	Yes	No	0	9	9
15	R:R:N52	R:R:P409	13.03	No	No	0	9	9
16	R:R:A77	R:R:V55	5.09	No	No	0	9	9
17	R:R:P413	R:R:V55	7.07	No	No	0	9	9
18	R:R:I78	R:R:M56	4.37	No	No	0	8	7
19	R:R:F81	R:R:M56	12.44	No	No	0	8	7
20	R:R:F59	R:R:R66	14.97	No	No	0	8	8
21	R:R:F59	R:R:F71	12.86	No	Yes	0	8	6
22	R:R:F59	R:R:L74	19.49	No	No	0	8	8
23	R:R:A61	R:R:L426	4.73	No	Yes	0	7	8
24	R:R:D62	R:R:S64	10.31	Yes	No	3	8	7
25	R:R:D62	R:R:L65	10.86	Yes	No	0	8	9
26	R:R:D62	R:R:R421	5.96	Yes	No	3	8	6
27	R:R:R421	R:R:S64	5.27	No	No	3	6	7
28	R:R:L65	R:R:N70	4.12	No	Yes	0	9	9
29	R:R:N70	R:R:T67	10.24	Yes	No	0	9	8
30	R:R:Q146	R:R:T67	8.5	No	No	0	8	8
31	R:R:Q68	R:R:R151	7.01	No	No	0	8	7
32	R:R:K155	R:R:Q68	4.07	Yes	No	0	7	8
33	R:R:L73	R:R:N69	5.49	Yes	No	0	8	8
34	R:R:D131	R:R:N69	8.08	No	No	0	9	8
35	R:R:H416	R:R:N69	7.65	Yes	No	0	9	8
36	R:R:H416	R:R:N70	5.1	Yes	Yes	4	9	9
37	R:R:F419	R:R:N70	8.46	Yes	Yes	4	9	9
38	R:R:F71	R:R:T149	5.19	Yes	No	0	6	6
39	R:R:A152	R:R:F71	4.16	No	Yes	0	8	6
40	R:R:F72	R:R:L127	19.49	No	No	5	9	8
41	R:R:D131	R:R:F72	7.17	No	No	0	9	9
42	R:R:F72	R:R:K155	7.44	No	Yes	5	9	7
43	R:R:I128	R:R:L73	4.28	No	Yes	0	9	8
44	R:R:L73	R:R:P413	6.57	Yes	No	0	8	9
45	R:R:F419	R:R:L73	6.09	Yes	Yes	0	9	8
46	R:R:I78	R:R:L74	7.14	No	No	0	8	8
47	R:R:N124	R:R:N75	16.35	No	No	0	8	9
48	R:R:M156	R:R:N75	9.82	No	No	0	9	9
49	R:R:N75	R:R:W160	11.3	No	No	0	9	9
50	R:R:D80	R:R:L76	5.43	Yes	Yes	2	9	9
51	R:R:L76	R:R:N124	9.61	Yes	No	0	9	8
52	R:R:L76	R:R:N408	10.98	Yes	Yes	2	9	9
53	R:R:L76	R:R:Y412	4.69	Yes	Yes	0	9	9
54	R:R:S120	R:R:S79	6.52	No	No	0	8	8
55	R:R:D80	R:R:S121	7.36	Yes	No	0	9	9
56	R:R:D80	R:R:S405	8.83	Yes	No	0	9	9
57	R:R:D80	R:R:N408	8.08	Yes	Yes	2	9	9
58	R:R:A85	R:R:F81	4.16	No	No	0	6	8
59	R:R:L117	R:R:L82	6.92	No	No	0	7	6
60	R:R:L117	R:R:V83	4.47	No	No	0	7	9
61	R:R:S405	R:R:V83	8.08	No	No	0	9	9
62	R:R:G84	R:R:I88	5.29	No	No	0	9	9
63	R:R:F86	R:R:L90	8.53	No	No	0	6	6
64	R:R:F86	R:R:V113	6.55	No	No	0	6	6
65	R:R:C87	R:R:D114	6.22	No	Yes	0	9	9
66	R:R:I88	R:R:W402	15.27	No	Yes	0	9	8
67	R:R:Y91	R:R:Y94	14.89	Yes	No	0	8	6
68	R:R:W110	R:R:Y91	10.61	Yes	Yes	0	6	8
69	R:R:E395	R:R:Y91	5.61	No	Yes	0	6	8
70	R:R:F398	R:R:Y91	11.35	Yes	Yes	1	7	8
71	R:R:W402	R:R:Y91	7.72	Yes	Yes	1	8	8
72	R:R:L96	R:R:V92	4.47	No	No	0	7	7
73	R:R:F102	R:R:P93	4.33	Yes	No	0	8	7
74	R:R:W100	R:R:Y94	5.79	Yes	No	0	9	6
75	R:R:H187	R:R:Y94	4.36	No	No	0	3	6
76	R:R:G186	R:R:R99	4.5	No	No	0	3	4
77	R:R:F102	R:R:W100	10.02	Yes	Yes	0	8	9
78	R:R:C107	R:R:W100	5.22	No	Yes	6	9	9
79	R:R:W100	R:R:W110	6.56	Yes	Yes	0	9	6
80	R:R:C188	R:R:W100	16.98	No	Yes	6	9	9
81	R:R:F102	R:R:L106	6.09	Yes	No	0	8	5
82	R:R:K108	R:R:R104	17.33	No	No	0	7	4
83	R:R:E175	R:R:R104	4.65	No	No	0	5	4
84	R:R:C107	R:R:C188	7.28	No	No	6	9	9
85	R:R:K108	R:R:L172	4.23	No	No	0	7	5
86	R:R:L111	R:R:W110	5.69	No	Yes	0	7	6
87	R:R:D114	R:R:W110	10.05	Yes	Yes	0	9	6
88	R:R:I171	R:R:L111	4.28	No	No	0	7	7
89	R:R:L172	R:R:V112	4.47	No	No	0	5	8
90	R:R:D114	R:R:W402	11.17	Yes	Yes	1	9	8
91	R:R:Y115	R:R:Y167	15.89	Yes	Yes	1	9	8
92	R:R:I171	R:R:Y115	6.04	No	Yes	0	7	9
93	R:R:F192	R:R:Y115	7.22	Yes	Yes	1	7	9
94	R:R:F123	R:R:T119	5.19	No	No	0	7	9
95	R:R:E206	R:R:T119	8.47	Yes	No	0	8	9
96	R:R:S120	R:R:W160	9.88	No	No	0	8	9
97	R:R:A122	R:R:W371	5.19	No	Yes	0	9	8
98	R:R:N124	R:R:V159	7.39	No	No	0	8	8
99	R:R:I125	R:R:N408	5.66	No	Yes	0	8	9
100	R:R:I125	R:R:Y412	10.88	No	Yes	0	8	9
101	R:R:K155	R:R:L127	4.23	Yes	No	5	7	8
102	R:R:I128	R:R:Y412	7.25	No	Yes	0	9	9
103	R:R:S129	R:R:V214	6.46	No	No	0	9	9
104	R:R:N218	R:R:S129	5.96	No	No	0	9	9
105	R:R:L134	R:R:Y130	12.89	No	No	0	5	7
106	R:R:F217	R:R:Y130	10.32	Yes	No	0	8	7
107	R:R:D131	R:R:Y142	10.34	No	No	0	9	9
108	R:R:R132	R:R:Y412	4.12	No	Yes	0	9	9
109	R:R:F133	R:R:T137	15.56	No	No	0	9	8
110	R:R:F133	R:R:F217	10.72	No	Yes	0	9	8
111	R:R:S135	R:R:Y142	8.9	No	No	0	9	9
112	R:R:N224	R:R:V136	4.43	No	No	0	7	8
113	R:R:Q145	R:R:S141	8.66	No	No	0	6	5
114	R:R:Q146	R:R:Y142	4.51	No	No	0	8	9
115	R:R:Q145	R:R:R151	11.68	No	No	0	6	7
116	R:R:D148	R:R:R151	13.1	No	No	0	8	7
117	R:R:L158	R:R:R154	4.86	No	No	0	4	3
118	R:R:L158	R:R:L162	5.54	No	No	0	4	6
119	R:R:F164	R:R:G168	4.52	Yes	No	0	7	6
120	R:R:F164	R:R:P169	4.33	Yes	No	0	7	8
121	R:R:F192	R:R:Y167	4.13	Yes	Yes	1	7	8
122	R:R:F198	R:R:Y167	4.13	Yes	Yes	1	7	8
123	R:R:E206	R:R:Y167	15.71	Yes	Yes	0	8	8
124	R:R:A170	R:R:F198	4.16	No	Yes	0	8	7
125	R:R:S178	R:R:W174	6.18	No	No	0	3	5
126	R:R:E191	R:R:W174	13.08	No	No	0	8	5
127	R:R:N195	R:R:W174	6.78	No	No	0	6	5
128	R:R:E175	R:R:S181	8.62	No	No	0	5	4
129	R:R:E175	R:R:E191	7.61	No	No	0	5	8
130	R:R:I183	R:R:Y189	6.04	No	No	0	4	4
131	R:R:E191	R:R:I183	4.1	No	No	0	8	4
132	R:R:H187	R:R:P184	4.58	No	No	0	3	3
133	R:R:P184	R:R:Y189	4.17	No	No	0	3	4
134	R:R:F193	R:R:Y189	14.44	Yes	No	0	5	4
135	R:R:A190	R:R:F192	8.32	No	Yes	0	7	7
136	R:R:F192	R:R:F198	18.22	Yes	Yes	1	7	7
137	R:R:F193	R:R:Y194	13.41	Yes	No	1	5	6
138	R:R:F193	R:R:M378	4.98	Yes	No	1	5	8
139	R:R:F193	R:R:R381	18.17	Yes	Yes	1	5	4
140	R:R:F193	R:R:Y394	8.25	Yes	Yes	1	5	4
141	R:R:R381	R:R:Y194	7.2	Yes	No	1	4	6
142	R:R:F198	R:R:N195	4.83	Yes	No	0	7	6
143	R:R:W196	R:R:Y197	11.58	No	No	0	5	5
144	R:R:A202	R:R:F198	4.16	No	Yes	0	9	7
145	R:R:I200	R:R:I379	4.42	No	No	0	7	6
146	R:R:F208	R:R:T204	5.19	Yes	No	0	7	6
147	R:R:E206	R:R:W371	7.63	Yes	Yes	0	8	8
148	R:R:F207	R:R:F208	6.43	Yes	Yes	0	9	7
149	R:R:F207	R:R:F211	8.57	Yes	Yes	1	9	8
150	R:R:F207	R:R:F367	5.36	Yes	No	1	9	9
151	R:R:F207	R:R:W371	9.02	Yes	Yes	1	9	8
152	R:R:F207	R:R:T375	7.78	Yes	No	0	9	8
153	R:R:F211	R:R:T215	6.49	Yes	No	0	8	6
154	R:R:F211	R:R:F367	4.29	Yes	No	1	8	9
155	R:R:F211	R:R:G368	4.52	Yes	No	0	8	7
156	R:R:F216	R:R:F217	6.43	No	Yes	0	5	8
157	R:R:F216	R:R:S220	7.93	No	No	0	5	8
158	R:R:L360	R:R:N218	5.49	No	No	0	8	9
159	R:R:N218	R:R:V364	4.43	No	No	0	9	8
160	R:R:Q226	R:R:Y222	16.91	No	No	0	7	7
161	R:R:N224	R:R:R227	8.44	No	No	0	7	5
162	R:R:D353	R:R:I225	5.6	No	No	0	9	8
163	R:R:R349	R:R:T229	12.94	Yes	No	0	6	6
164	R:R:D353	R:R:T229	8.67	No	No	0	9	6
165	R:R:A236	R:R:R232	5.53	No	No	0	3	5
166	R:R:R232	R:R:R349	10.66	No	Yes	0	5	6
167	R:R:L233	R:R:Q346	6.65	No	No	0	5	5
168	R:R:D234	R:R:G235	6.71	No	No	0	4	4
169	R:R:L350	R:R:R347	6.07	No	No	0	6	5
170	R:R:I363	R:R:Y412	6.04	No	Yes	0	8	9
171	R:R:I366	R:R:L411	4.28	No	No	0	7	9
172	R:R:F367	R:R:W371	8.02	No	Yes	1	9	8
173	R:R:C370	R:R:N404	11.02	No	No	0	8	9
174	R:R:L401	R:R:W371	15.94	No	Yes	1	8	8
175	R:R:N404	R:R:W371	7.91	No	Yes	0	9	8
176	R:R:M378	R:R:Y374	16.76	No	Yes	1	8	9
177	R:R:Y374	R:R:Y394	4.96	Yes	Yes	1	9	4
178	R:R:S397	R:R:Y374	6.36	No	Yes	0	7	9
179	R:R:F398	R:R:Y374	9.28	Yes	Yes	1	7	9
180	R:R:L401	R:R:Y374	4.69	No	Yes	1	8	9
181	R:R:L377	R:R:S397	6.01	No	No	0	7	7
182	R:R:M378	R:R:R381	7.44	No	Yes	1	8	4
183	R:R:R381	R:R:V389	5.23	Yes	No	0	4	5
184	R:R:C384	R:R:C388	7.28	No	No	0	7	8
185	R:R:P390	R:R:Y392	12.52	No	No	7	7	3
186	R:R:P390	R:R:W393	14.86	No	No	7	7	6
187	R:R:W393	R:R:Y392	7.72	No	No	7	6	3
188	R:R:E395	R:R:Y394	6.73	No	Yes	0	6	4
189	R:R:F398	R:R:Y394	5.16	Yes	Yes	1	7	4
190	R:R:F398	R:R:W402	9.02	Yes	Yes	1	7	8
191	R:R:W399	R:R:W402	11.25	No	Yes	0	9	8
192	R:R:N404	R:R:N408	6.81	No	Yes	0	9	9
193	R:R:L411	R:R:V407	4.47	No	No	0	9	7
194	R:R:L411	R:R:Y412	4.69	No	Yes	0	9	9
195	R:R:H416	R:R:S418	5.58	Yes	No	0	9	8
196	R:R:F419	R:R:H416	6.79	Yes	Yes	4	9	9
197	R:R:F348	R:R:S351	3.96	No	No	0	4	6
198	R:R:R138	R:R:T137	3.88	No	No	0	6	8
199	R:R:V95	R:R:Y91	3.79	No	Yes	0	6	8
200	R:R:F71	R:R:M156	3.73	Yes	No	0	6	9
201	R:R:F123	R:R:L166	3.65	No	No	0	7	8
202	R:R:G84	R:R:T48	3.64	No	No	0	9	9
203	R:R:G98	R:R:T97	3.64	No	No	0	7	5
204	R:R:K108	R:R:Y176	3.58	No	No	0	7	5
205	R:R:P210	R:R:V126	3.53	No	No	0	9	8
206	R:R:P390	R:R:V389	3.53	No	No	0	7	5
207	R:R:P210	R:R:T209	3.5	No	No	0	9	7
208	R:R:L90	R:R:W110	3.42	No	Yes	0	6	6
209	R:R:L116	R:R:W160	3.42	No	No	0	8	9
210	R:R:A163	R:R:T119	3.36	No	No	0	8	9
211	R:R:L400	R:R:P373	3.28	No	No	0	9	9
212	R:R:F419	R:R:F423	3.22	Yes	No	0	9	9
213	R:R:S203	R:R:T375	3.2	No	No	0	8	8
214	R:R:R227	R:R:R228	3.2	No	No	0	5	8
215	R:R:R228	R:R:R349	3.2	No	Yes	0	8	6
216	R:R:S343	R:R:T345	3.2	No	No	0	3	7
217	R:R:T215	R:R:V364	3.17	No	No	0	6	8
218	R:R:A422	R:R:D62	3.09	No	Yes	0	9	8
219	R:R:I221	R:R:V136	3.07	No	No	0	9	8
220	R:R:I225	R:R:V356	3.07	No	No	0	8	8
221	R:R:G386	R:R:R381	3	No	Yes	0	3	4
222	R:R:L50	R:R:V49	2.98	No	No	0	5	7
223	R:R:L157	R:R:V153	2.98	No	No	0	5	5
224	R:R:L360	R:R:V356	2.98	No	No	0	8	8
225	R:R:L44	R:R:T48	2.95	No	No	0	7	9
226	R:R:G103	R:R:W100	2.81	No	Yes	0	8	9
227	R:R:A58	R:R:F423	2.77	No	No	0	9	9
228	R:R:L106	R:R:L109	2.77	No	No	0	5	6
229	R:R:A372	R:R:F207	2.77	No	Yes	0	7	9
230	R:R:A357	R:R:Y222	2.67	No	No	0	8	7
231	R:R:F217	R:R:S129	2.64	Yes	No	0	8	9
232	R:R:F164	R:R:V112	2.62	Yes	No	0	7	8
233	R:R:F102	R:R:T101	2.59	Yes	No	0	8	5
234	R:R:A382	R:R:W196	2.59	No	No	0	7	5
235	R:R:A383	R:R:W196	2.59	No	No	0	5	5
236	R:R:F208	R:R:I379	2.51	Yes	No	0	7	6
237	R:R:K155	R:R:R154	2.48	Yes	No	0	7	3
238	R:R:K355	R:R:R352	2.48	No	No	0	8	8
239	R:R:F164	R:R:L165	2.44	Yes	No	0	7	5
240	R:R:F192	R:R:L199	2.44	Yes	No	0	7	8
241	R:R:L414	R:R:R420	2.43	No	No	0	7	9
242	R:R:D148	R:R:R150	2.38	No	No	0	8	7
243	R:R:L223	R:R:Y222	2.34	No	No	0	5	7
244	R:R:N195	R:R:Y197	2.33	No	No	0	6	5
245	R:R:H417	R:R:R420	2.26	No	No	0	5	9
246	R:R:R227	R:R:R230	2.13	No	No	0	5	6
247	R:R:R349	R:R:R352	2.13	Yes	No	0	6	8
248	R:R:G179	R:R:G180	2.11	No	No	0	5	2
249	R:R:C384	R:R:G386	1.96	No	No	0	7	3
250	R:R:A372	R:R:P373	1.87	No	No	0	7	9
251	R:R:A35	R:R:T34	1.68	No	No	0	5	5
252	R:R:A406	R:R:T48	1.68	No	No	0	7	9
253	R:R:G147	R:R:Q146	1.64	No	No	0	6	8
254	R:R:E185	R:R:G186	1.64	No	No	0	1	3
255	R:R:C388	R:R:I380	1.64	No	No	0	8	7
256	R:R:S213	R:R:V126	1.62	No	No	0	8	8
257	R:R:A53	R:R:M56	1.61	No	No	0	6	7
258	R:R:V126	R:R:V214	1.6	No	No	0	8	9
259	R:R:A58	R:R:L426	1.58	No	Yes	0	9	8
260	R:R:I363	R:R:S359	1.55	No	No	0	8	9
261	R:R:I366	R:R:V362	1.54	No	No	0	7	8
262	R:R:I200	R:R:T201	1.52	No	No	0	7	6
263	R:R:A236	R:R:Q346	1.52	No	No	0	3	5
264	R:R:G105	R:R:R104	1.5	No	No	0	5	4
265	R:R:L50	R:R:V46	1.49	No	No	0	5	5
266	R:R:L165	R:R:V161	1.49	No	No	0	5	5
267	R:R:L414	R:R:V410	1.49	No	No	0	7	7
268	R:R:D62	R:R:S63	1.47	Yes	No	0	8	8
269	R:R:L350	R:R:T229	1.47	No	No	0	6	6
270	R:R:Q346	R:R:T345	1.42	No	No	0	5	7
271	R:R:H417	R:R:S418	1.39	No	No	0	5	8
272	R:R:L426	R:R:L57	1.38	Yes	No	0	8	7
273	R:R:L166	R:R:L205	1.38	No	No	0	8	6
274	R:R:L219	R:R:L223	1.38	No	No	0	4	5
275	R:R:L426	R:R:L427	1.38	Yes	No	0	8	8
276	R:R:D353	R:R:Q226	1.31	No	No	0	9	7
277	R:R:F423	R:R:L54	1.22	No	No	0	9	8
278	R:R:F208	R:R:L376	1.22	Yes	No	0	7	7
279	R:R:F211	R:R:L212	1.22	Yes	No	0	8	5
280	R:R:H385	R:R:Y194	1.09	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	13	8	1	0
2	R:R:D62	6.338	5	3	8
3	R:R:N70	6.98	4	4	9
4	R:R:F71	6.485	4	0	6
5	R:R:L73	5.6075	4	0	8
6	R:R:L76	7.6775	4	2	9
7	R:R:D80	7.286	5	2	9
8	R:R:Y91	8.995	6	1	8
9	R:R:W100	7.89667	6	6	9
10	R:R:F102	5.7575	4	0	8
11	R:R:W110	7.266	5	0	6
12	R:R:D114	8.7925	4	1	9
13	R:R:Y115	9.435	4	1	9
14	R:R:K155	4.555	4	5	7
15	R:R:F164	3.4775	4	0	7
16	R:R:Y167	9.965	4	1	8
17	R:R:F192	8.066	5	1	7
18	R:R:F193	11.85	5	1	5
19	R:R:F198	7.1	5	1	7
20	R:R:E206	11.19	4	0	8
21	R:R:F207	6.655	6	1	9
22	R:R:F208	3.8375	4	0	7
23	R:R:F211	5.018	5	1	8
24	R:R:F217	7.5275	4	0	8
25	R:R:R349	7.2325	4	0	6
26	R:R:W371	8.95167	6	1	8
27	R:R:Y374	10.19	6	1	9
28	R:R:R381	8.208	5	1	4
29	R:R:Y394	6.275	4	1	4
30	R:R:F398	11.126	5	1	7
31	R:R:W402	10.9267	6	1	8
32	R:R:N408	7.8825	4	2	9
33	R:R:Y412	6.27833	6	0	9
34	R:R:H416	6.28	4	4	9
35	R:R:F419	6.14	4	4	9
36	R:R:L426	2.2675	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W402	22.395	11.13	Yes	Yes	1	0	8
2	R:R:I88	R:R:W402	11.4383	15.27	No	Yes	0	9	8
3	L:L:?1	R:R:E206	29.3264	12.95	Yes	Yes	0	0	8
4	R:R:E206	R:R:W371	50.2648	7.63	Yes	Yes	0	8	8
5	R:R:N404	R:R:W371	100	7.91	No	Yes	0	9	8
6	R:R:N404	R:R:N408	99.4703	6.81	No	Yes	0	9	9
7	R:R:L76	R:R:N408	54.1699	10.98	Yes	Yes	2	9	9
8	R:R:L76	R:R:N124	18.0061	9.61	Yes	No	0	9	8
9	R:R:N124	R:R:N75	16.4652	16.35	No	No	0	8	9
10	R:R:M156	R:R:N75	12.5289	9.82	No	No	0	9	9
11	R:R:F71	R:R:M156	11.7272	3.73	Yes	No	0	6	9
12	L:L:?1	R:R:L401	26.8779	14.65	Yes	No	1	0	8
13	R:R:L401	R:R:W371	49.0177	15.94	No	Yes	1	8	8
14	R:R:L76	R:R:Y412	43.8824	4.69	Yes	Yes	0	9	9
15	R:R:I128	R:R:Y412	73.4953	7.25	No	Yes	0	9	9
16	R:R:I128	R:R:L73	72.2337	4.28	No	Yes	0	9	8
17	R:R:I125	R:R:N408	39.9942	5.66	No	Yes	0	8	9
18	R:R:I125	R:R:Y412	39.4766	10.88	No	Yes	0	8	9
19	R:R:F419	R:R:L73	33.8766	6.09	Yes	Yes	0	9	8
20	R:R:F419	R:R:F423	10.6486	3.22	Yes	No	0	9	9
21	R:R:F419	R:R:N70	14.2166	8.46	Yes	Yes	4	9	9
22	R:R:L73	R:R:N69	33.8766	5.49	Yes	No	0	8	8
23	R:R:D131	R:R:N69	24.8315	8.08	No	No	0	9	8
24	R:R:D131	R:R:F72	17.8231	7.17	No	No	0	9	9
25	R:R:F72	R:R:K155	14.8763	7.44	No	Yes	5	9	7
26	L:L:?1	R:R:D114	22.8019	7.73	Yes	Yes	1	0	9
27	R:R:D114	R:R:W110	20.0308	10.05	Yes	Yes	0	9	6
28	R:R:F398	R:R:Y91	10.0226	11.35	Yes	Yes	1	7	8
29	R:R:W100	R:R:W110	14.8425	6.56	Yes	Yes	0	9	6
30	R:R:F198	R:R:Y167	18.7813	4.13	Yes	Yes	1	7	8
31	R:R:F198	R:R:N195	17.3055	4.83	Yes	No	0	7	6
32	R:R:N195	R:R:W174	12.2833	6.78	No	No	0	6	5
33	R:R:E191	R:R:W174	10.7738	13.08	No	No	0	8	5
34	R:R:E175	R:R:E191	12.1437	7.61	No	No	0	5	8
35	R:R:E175	R:R:R104	10.3501	4.65	No	No	0	5	4
36	R:R:E206	R:R:Y167	21.6078	15.71	Yes	Yes	0	8	8
37	R:R:M378	R:R:Y374	14.5922	16.76	No	Yes	1	8	9
38	R:R:F207	R:R:W371	44.4361	9.02	Yes	Yes	1	9	8
39	R:R:F207	R:R:F211	36.7537	8.57	Yes	Yes	1	9	8
40	R:R:F211	R:R:T215	67.9459	6.49	Yes	No	0	8	6
41	R:R:T215	R:R:V364	66.4941	3.17	No	No	0	6	8
42	R:R:N218	R:R:V364	65.0376	4.43	No	No	0	9	8
43	R:R:N218	R:R:S129	22.7826	5.96	No	No	0	9	9
44	R:R:F367	R:R:W371	36.1614	8.02	No	Yes	1	9	8
45	R:R:F211	R:R:F367	35.5162	4.29	Yes	No	1	8	9
46	R:R:F217	R:R:S129	13.1332	2.64	Yes	No	0	8	9
47	R:R:L360	R:R:N218	42.6112	5.49	No	No	0	8	9
48	R:R:L360	R:R:V356	41.0728	2.98	No	No	0	8	8
49	R:R:I225	R:R:V356	39.6933	3.07	No	No	0	8	8
50	R:R:D353	R:R:I225	38.3089	5.6	No	No	0	9	8
51	R:R:D353	R:R:T229	28.946	8.67	No	No	0	9	6
52	R:R:R349	R:R:T229	24.2007	12.94	Yes	No	0	6	6
53	R:R:H416	R:R:S418	14.4068	5.58	Yes	No	0	9	8
54	R:R:H417	R:R:S418	11.5346	1.39	No	No	0	5	8
55	R:R:L401	R:R:Y374	21.8052	4.69	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D114	7.73	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y115	8.59	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:C118	9.04	1	Yes	No	0	8	0	1
L:L:?1	R:R:E206	12.95	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y374	19.09	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F398	20.82	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L401	14.65	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	11.13	1	Yes	Yes	0	8	0	1
R:R:C87	R:R:D114	6.22	0	No	Yes	9	9	2	1
R:R:I88	R:R:W402	15.27	0	No	Yes	9	8	2	1
R:R:W110	R:R:Y91	10.61	0	Yes	Yes	6	8	2	2
R:R:F398	R:R:Y91	11.35	1	Yes	Yes	7	8	1	2
R:R:W402	R:R:Y91	7.72	1	Yes	Yes	8	8	1	2
R:R:D114	R:R:W110	10.05	1	Yes	Yes	9	6	1	2
R:R:D114	R:R:W402	11.17	1	Yes	Yes	9	8	1	1
R:R:Y115	R:R:Y167	15.89	1	Yes	Yes	9	8	1	2
R:R:I171	R:R:Y115	6.04	0	No	Yes	7	9	2	1
R:R:F192	R:R:Y115	7.22	1	Yes	Yes	7	9	2	1
R:R:E206	R:R:T119	8.47	0	Yes	No	8	9	1	2
R:R:F192	R:R:Y167	4.13	1	Yes	Yes	7	8	2	2
R:R:E206	R:R:Y167	15.71	0	Yes	Yes	8	8	1	2
R:R:E206	R:R:W371	7.63	0	Yes	Yes	8	8	1	2
R:R:L401	R:R:W371	15.94	1	No	Yes	8	8	1	2
R:R:M378	R:R:Y374	16.76	1	No	Yes	8	9	2	1
R:R:Y374	R:R:Y394	4.96	1	Yes	Yes	9	4	1	2
R:R:S397	R:R:Y374	6.36	0	No	Yes	7	9	2	1
R:R:F398	R:R:Y374	9.28	1	Yes	Yes	7	9	1	1
R:R:L401	R:R:Y374	4.69	1	No	Yes	8	9	1	1
R:R:F398	R:R:Y394	5.16	1	Yes	Yes	7	4	1	2
R:R:F398	R:R:W402	9.02	1	Yes	Yes	7	8	1	1
R:R:W399	R:R:W402	11.25	0	No	Yes	9	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YN6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.06
Number of Linked Nodes	258
Number of Links	280
Number of Hubs	36
Number of Links mediated by Hubs	134
Number of Communities	7
Number of Nodes involved in Communities	38
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	72936
Length Of Smallest Path	3
Average Path Length	14.9101
Length of Longest Path	32
Minimum Path Strength	1.38
Average Path Strength	7.48588
Maximum Path Strength	17.925
Minimum Path Correlation	0.7
Average Path Correlation	0.93092
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	50.0498
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.1981
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cellular localization • neurotransmitter secretion • transport • secretion • export from cell • neurotransmitter transport • establishment of localization • localization • signal release from synapse • secretion by cell • signal release • establishment of localization in cell • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • presynapse • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ITF
Name	2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate
Synonyms
Identifier
Formula	C6 H10 N4 S
Molecular Weight	170.235
SMILES
PubChem	3692
Formal Charge	0
Total Atoms	21
Total Chiral Atoms	0
Total Bonds	21
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5N1
Sequence	>8YN6_nogp_Chain_R T A V L A A L M A L L I V A T V L G N A L V M L A F V A D S S L R T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R W T F G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R A V S Y R A Q Q G D T R R A V R K M L L V W V L A F L L Y G P A I L S W E Y L S G G S S I P E G H C Y A E F F Y N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G A S F T Q R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C H G H C V P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F R R A F T K L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F61	A	Amine	Histamine	H₃	Homo sapiens	PF-03654746	-	-	2.6	2022-10-26	doi.org/10.1038/s41467-022-33880-y
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8TH3	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	AT118-H Nanobody	-	3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8YUU	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ1	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUU (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUV	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-	Gi1/β1/γ2	3	2024-06-05	doi.org/10.1002/advs.202310120
	8YUV (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-		3	2024-06-05	doi.org/10.1002/advs.202310120
	8YN5	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-	Gi1/β1/γ2	2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-		2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN7	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN7 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	9JEQ	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	3.05	2025-09-24	doi.org/10.1038/s41401-025-01633-4
	9JEQ (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		3.05	2025-09-24	doi.org/10.1038/s41401-025-01633-4
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	9JH3	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 175670646	Na	-	1.71	2025-06-18	doi.org/10.1038/s41467-025-60629-0

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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