psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D114	6.9	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y115	8.61	Yes	Yes	1	0	9
3	L:L:?1	R:R:C118	7.17	Yes	No	0	0	8
4	L:L:?1	R:R:Y167	6.62	Yes	Yes	1	0	8
5	L:L:?1	R:R:E206	9.73	Yes	Yes	1	0	8
6	L:L:?1	R:R:Y374	9.27	Yes	Yes	1	0	9
7	L:L:?1	R:R:T375	5.83	Yes	No	0	0	8
8	L:L:?1	R:R:F398	14.45	Yes	Yes	1	0	7
9	L:L:?1	R:R:L401	10.95	Yes	No	1	0	8
10	L:L:?1	R:R:W402	7.08	Yes	Yes	1	0	8
11	R:R:M41	R:R:V92	6.09	No	No	0	7	7
12	R:R:M41	R:R:W399	5.82	No	Yes	0	7	9
13	R:R:I45	R:R:I88	4.42	No	No	0	7	9
14	R:R:I45	R:R:P89	10.16	No	No	0	7	9
15	R:R:G84	R:R:T48	3.64	No	No	0	9	9
16	R:R:D80	R:R:N52	6.73	Yes	No	0	9	9
17	R:R:N52	R:R:P409	11.4	No	No	0	9	9
18	R:R:A77	R:R:V55	5.09	No	No	0	9	9
19	R:R:P413	R:R:V55	7.07	No	No	0	9	9
20	R:R:F81	R:R:M56	12.44	No	No	0	8	7
21	R:R:F59	R:R:R66	16.03	No	No	0	8	8
22	R:R:F59	R:R:F71	8.57	No	Yes	0	8	6
23	R:R:F59	R:R:L74	18.27	No	No	0	8	8
24	R:R:A61	R:R:L426	4.73	No	Yes	0	7	8
25	R:R:D62	R:R:S64	10.31	No	No	0	8	7
26	R:R:D62	R:R:L65	10.86	No	No	0	8	9
27	R:R:L65	R:R:N70	5.49	No	No	2	9	9
28	R:R:F419	R:R:L65	3.65	Yes	No	2	9	9
29	R:R:N70	R:R:T67	10.24	No	No	0	9	8
30	R:R:Q146	R:R:T67	7.09	No	No	0	8	8
31	R:R:Q68	R:R:R151	4.67	No	No	0	8	7
32	R:R:L73	R:R:N69	5.49	Yes	No	2	8	8
33	R:R:D131	R:R:N69	6.73	No	No	0	9	8
34	R:R:H416	R:R:N69	7.65	Yes	No	2	9	8
35	R:R:F419	R:R:N70	7.25	Yes	No	2	9	9
36	R:R:F71	R:R:T149	5.19	Yes	No	0	6	6
37	R:R:A152	R:R:F71	5.55	No	Yes	0	8	6
38	R:R:F71	R:R:M156	3.73	Yes	No	0	6	9
39	R:R:F72	R:R:L127	18.27	No	No	3	9	8
40	R:R:D131	R:R:F72	7.17	No	No	0	9	9
41	R:R:F72	R:R:K155	4.96	No	No	3	9	7
42	R:R:I128	R:R:L73	4.28	Yes	Yes	2	9	8
43	R:R:H416	R:R:L73	3.86	Yes	Yes	2	9	8
44	R:R:F419	R:R:L73	6.09	Yes	Yes	2	9	8
45	R:R:I78	R:R:L74	7.14	No	No	0	8	8
46	R:R:N124	R:R:N75	16.35	No	No	0	8	9
47	R:R:M156	R:R:N75	11.22	No	No	0	9	9
48	R:R:N75	R:R:W160	12.43	No	Yes	0	9	9
49	R:R:D80	R:R:L76	8.14	Yes	Yes	2	9	9
50	R:R:L76	R:R:N124	5.49	Yes	No	0	9	8
51	R:R:I128	R:R:L76	4.28	Yes	Yes	2	9	9
52	R:R:L76	R:R:N408	10.98	Yes	Yes	2	9	9
53	R:R:L76	R:R:Y412	4.69	Yes	Yes	2	9	9
54	R:R:S120	R:R:S79	6.52	No	No	4	8	8
55	R:R:S79	R:R:W160	6.18	No	Yes	4	8	9
56	R:R:D80	R:R:S121	7.36	Yes	No	0	9	9
57	R:R:D80	R:R:S405	8.83	Yes	No	0	9	9
58	R:R:D80	R:R:N408	8.08	Yes	Yes	2	9	9
59	R:R:F81	R:R:L82	3.65	No	No	0	8	6
60	R:R:L117	R:R:L82	6.92	No	No	0	7	6
61	R:R:L117	R:R:V83	4.47	No	No	0	7	9
62	R:R:V83	R:R:W402	3.68	No	Yes	0	9	8
63	R:R:S405	R:R:V83	8.08	No	No	0	9	9
64	R:R:G84	R:R:I88	5.29	No	No	0	9	9
65	R:R:F86	R:R:L90	3.65	No	No	0	6	6
66	R:R:F86	R:R:V113	7.87	No	No	0	6	6
67	R:R:C87	R:R:D114	6.22	No	Yes	0	9	9
68	R:R:I88	R:R:W402	17.62	No	Yes	0	9	8
69	R:R:Y91	R:R:Y94	12.91	Yes	No	0	8	6
70	R:R:V95	R:R:Y91	3.79	No	Yes	0	6	8
71	R:R:W110	R:R:Y91	10.61	Yes	Yes	1	6	8
72	R:R:E395	R:R:Y91	5.61	No	Yes	1	6	8
73	R:R:F398	R:R:Y91	12.38	Yes	Yes	1	7	8
74	R:R:W399	R:R:Y91	4.82	Yes	Yes	1	9	8
75	R:R:W402	R:R:Y91	8.68	Yes	Yes	1	8	8
76	R:R:P93	R:R:V92	3.53	No	No	0	7	7
77	R:R:F102	R:R:P93	7.22	Yes	No	0	8	7
78	R:R:W100	R:R:Y94	7.72	Yes	No	0	9	6
79	R:R:F102	R:R:W100	15.03	Yes	Yes	0	8	9
80	R:R:C107	R:R:W100	5.22	No	Yes	1	9	9
81	R:R:W100	R:R:W110	4.69	Yes	Yes	1	9	6
82	R:R:C188	R:R:W100	16.98	No	Yes	1	9	9
83	R:R:F102	R:R:L106	6.09	Yes	No	0	8	5
84	R:R:C107	R:R:C188	7.28	No	No	1	9	9
85	R:R:L111	R:R:W110	4.56	No	Yes	0	7	6
86	R:R:D114	R:R:W110	6.7	Yes	Yes	1	9	6
87	R:R:W110	R:R:W402	3.75	Yes	Yes	1	6	8
88	R:R:C188	R:R:L111	4.76	No	No	0	9	7
89	R:R:I171	R:R:V112	4.61	No	No	0	7	8
90	R:R:D114	R:R:W402	11.17	Yes	Yes	1	9	8
91	R:R:Y115	R:R:Y167	8.94	Yes	Yes	1	9	8
92	R:R:I171	R:R:Y115	3.63	No	Yes	1	7	9
93	R:R:F192	R:R:Y115	6.19	Yes	Yes	1	7	9
94	R:R:L116	R:R:W160	5.69	No	Yes	0	8	9
95	R:R:F123	R:R:T119	5.19	No	No	0	7	9
96	R:R:E206	R:R:T119	12.7	Yes	No	0	8	9
97	R:R:S120	R:R:W160	9.88	No	Yes	4	8	9
98	R:R:A122	R:R:W371	5.19	No	Yes	0	9	8
99	R:R:N124	R:R:V159	7.39	No	No	0	8	8
100	R:R:F367	R:R:I125	6.28	No	No	0	9	8
101	R:R:I125	R:R:N408	5.66	No	Yes	2	8	9
102	R:R:I125	R:R:Y412	9.67	No	Yes	2	8	9
103	R:R:P210	R:R:V126	3.53	No	No	0	9	8
104	R:R:K155	R:R:L127	4.23	No	No	3	7	8
105	R:R:I128	R:R:R132	5.01	Yes	No	2	9	9
106	R:R:I128	R:R:Y412	4.84	Yes	Yes	2	9	9
107	R:R:S129	R:R:V214	8.08	No	No	5	9	9
108	R:R:N218	R:R:S129	4.47	Yes	No	5	9	9
109	R:R:L134	R:R:Y130	14.07	No	No	0	5	7
110	R:R:F217	R:R:Y130	9.28	No	No	0	8	7
111	R:R:D131	R:R:Y142	11.49	No	No	0	9	9
112	R:R:R132	R:R:Y412	8.23	No	Yes	2	9	9
113	R:R:F133	R:R:T137	10.38	No	No	0	9	8
114	R:R:F133	R:R:F217	9.65	No	No	0	9	8
115	R:R:F133	R:R:S220	5.28	No	No	0	9	8
116	R:R:S135	R:R:Y142	7.63	No	No	0	9	9
117	R:R:I221	R:R:V136	6.14	No	No	0	9	8
118	R:R:R138	R:R:T137	3.88	No	No	0	6	8
119	R:R:N224	R:R:T137	4.39	No	No	0	7	8
120	R:R:R138	R:R:S141	7.91	No	No	0	6	5
121	R:R:Q145	R:R:S141	5.78	No	No	0	6	5
122	R:R:Q145	R:R:R151	14.02	No	No	0	6	7
123	R:R:D148	R:R:R150	4.76	No	No	0	8	7
124	R:R:D148	R:R:R151	14.29	No	No	0	8	7
125	R:R:L158	R:R:L162	8.3	No	No	0	4	6
126	R:R:F164	R:R:G168	9.03	No	No	0	7	6
127	R:R:L166	R:R:Y167	10.55	No	Yes	0	8	8
128	R:R:F192	R:R:Y167	5.16	Yes	Yes	1	7	8
129	R:R:F198	R:R:Y167	4.13	Yes	Yes	1	7	8
130	R:R:A202	R:R:Y167	4	No	Yes	1	9	8
131	R:R:E206	R:R:Y167	8.98	Yes	Yes	1	8	8
132	R:R:G168	R:R:P169	4.06	No	No	0	6	8
133	R:R:F192	R:R:I171	5.02	Yes	No	1	7	7
134	R:R:L177	R:R:S173	4.5	No	No	0	4	6
135	R:R:S178	R:R:W174	6.18	No	Yes	0	3	5
136	R:R:E191	R:R:W174	14.17	No	Yes	0	8	5
137	R:R:N195	R:R:W174	4.52	No	Yes	1	6	5
138	R:R:F198	R:R:W174	4.01	Yes	Yes	1	7	5
139	R:R:E175	R:R:S181	5.75	Yes	No	0	5	4
140	R:R:E175	R:R:E191	17.76	Yes	No	0	5	8
141	R:R:I183	R:R:Y189	7.25	No	Yes	0	4	4
142	R:R:P184	R:R:Y189	5.56	No	Yes	0	3	4
143	R:R:F193	R:R:Y189	12.38	Yes	Yes	1	5	4
144	R:R:Y189	R:R:Y194	3.97	Yes	Yes	1	4	6
145	R:R:A190	R:R:F192	8.32	No	Yes	0	7	7
146	R:R:F192	R:R:F198	16.08	Yes	Yes	1	7	7
147	R:R:F193	R:R:Y194	8.25	Yes	Yes	1	5	6
148	R:R:F193	R:R:M378	6.22	Yes	No	1	5	8
149	R:R:F193	R:R:R381	18.17	Yes	Yes	1	5	4
150	R:R:F193	R:R:Y394	8.25	Yes	No	0	5	4
151	R:R:R381	R:R:Y194	6.17	Yes	Yes	1	4	6
152	R:R:H385	R:R:Y194	5.44	No	Yes	0	4	6
153	R:R:F198	R:R:N195	4.83	Yes	No	1	7	6
154	R:R:W196	R:R:Y197	10.61	Yes	No	0	5	5
155	R:R:I200	R:R:W196	4.7	No	Yes	0	7	5
156	R:R:A202	R:R:F198	4.16	No	Yes	1	9	7
157	R:R:F208	R:R:S203	3.96	Yes	No	0	7	8
158	R:R:I379	R:R:S203	4.64	No	No	0	6	8
159	R:R:F208	R:R:T204	5.19	Yes	No	0	7	6
160	R:R:E206	R:R:W371	7.63	Yes	Yes	0	8	8
161	R:R:F207	R:R:F208	5.36	Yes	Yes	0	9	7
162	R:R:F207	R:R:F211	7.5	Yes	Yes	6	9	8
163	R:R:F207	R:R:W371	7.02	Yes	Yes	0	9	8
164	R:R:F207	R:R:T375	12.97	Yes	No	0	9	8
165	R:R:F211	R:R:T215	7.78	Yes	No	0	8	6
166	R:R:N218	R:R:V214	4.43	Yes	No	5	9	9
167	R:R:F216	R:R:F217	5.36	No	No	0	5	8
168	R:R:F216	R:R:S220	7.93	No	No	0	5	8
169	R:R:L360	R:R:N218	6.87	No	Yes	0	8	9
170	R:R:N218	R:R:V364	4.43	Yes	No	0	9	8
171	R:R:L219	R:R:L223	4.15	No	No	0	4	5
172	R:R:I221	R:R:L360	4.28	No	No	0	9	8
173	R:R:Q226	R:R:Y222	15.78	No	No	0	7	7
174	R:R:N224	R:R:R227	6.03	No	No	0	7	5
175	R:R:D353	R:R:I225	5.6	No	No	0	9	8
176	R:R:R227	R:R:R228	4.26	No	No	0	5	8
177	R:R:R349	R:R:T229	11.64	Yes	No	0	6	6
178	R:R:D353	R:R:T229	8.67	No	No	0	9	6
179	R:R:D234	R:R:R230	5.96	No	No	0	4	6
180	R:R:R232	R:R:R349	9.6	No	Yes	0	5	6
181	R:R:L233	R:R:L350	4.15	No	No	0	5	6
182	R:R:S343	R:R:T345	4.8	No	No	0	3	7
183	R:R:Q346	R:R:S343	7.22	No	No	0	5	3
184	R:R:R347	R:R:S351	3.95	No	No	0	5	6
185	R:R:F348	R:R:S351	3.96	No	No	0	4	6
186	R:R:K358	R:R:V362	4.55	No	No	0	7	8
187	R:R:I363	R:R:Y412	3.63	No	Yes	0	8	9
188	R:R:I366	R:R:L411	4.28	No	No	0	7	9
189	R:R:F367	R:R:W371	7.02	No	Yes	0	9	8
190	R:R:C370	R:R:N404	9.45	No	No	0	8	9
191	R:R:L401	R:R:W371	15.94	No	Yes	0	8	8
192	R:R:N404	R:R:W371	6.78	No	Yes	0	9	8
193	R:R:M378	R:R:Y374	17.96	No	Yes	1	8	9
194	R:R:S397	R:R:Y374	6.36	No	Yes	0	7	9
195	R:R:F398	R:R:Y374	8.25	Yes	Yes	1	7	9
196	R:R:L401	R:R:Y374	5.86	No	Yes	1	8	9
197	R:R:L377	R:R:S397	6.01	No	No	0	7	7
198	R:R:M378	R:R:R381	7.44	No	Yes	1	8	4
199	R:R:R381	R:R:V389	5.23	Yes	No	0	4	5
200	R:R:C384	R:R:C388	7.28	No	No	0	7	8
201	R:R:P390	R:R:V389	3.53	No	No	0	7	5
202	R:R:P390	R:R:Y392	8.34	No	No	7	7	3
203	R:R:P390	R:R:W393	17.57	No	No	7	7	6
204	R:R:W393	R:R:Y392	8.68	No	No	7	6	3
205	R:R:E395	R:R:Y394	6.73	No	No	0	6	4
206	R:R:F398	R:R:Y394	5.16	Yes	No	0	7	4
207	R:R:E395	R:R:W399	4.36	No	Yes	1	6	9
208	R:R:F398	R:R:W402	10.02	Yes	Yes	1	7	8
209	R:R:W399	R:R:W402	11.25	Yes	Yes	1	9	8
210	R:R:N404	R:R:N408	12.26	No	Yes	0	9	9
211	R:R:L411	R:R:V407	4.47	No	No	0	9	7
212	R:R:N408	R:R:Y412	4.65	Yes	Yes	2	9	9
213	R:R:H416	R:R:S418	5.58	Yes	No	0	9	8
214	R:R:F419	R:R:H416	5.66	Yes	Yes	2	9	9
215	R:R:L411	R:R:Y412	3.52	No	Yes	0	9	9
216	R:R:P210	R:R:T209	3.5	No	No	0	9	7
217	R:R:G105	R:R:K108	3.49	No	No	0	5	7
218	R:R:L90	R:R:W110	3.42	No	Yes	0	6	6
219	R:R:A163	R:R:T119	3.36	No	No	0	8	9
220	R:R:L73	R:R:P413	3.28	Yes	No	0	8	9
221	R:R:L400	R:R:P373	3.28	No	No	0	9	9
222	R:R:H187	R:R:Y94	3.27	No	No	0	3	6
223	R:R:F419	R:R:F423	3.22	Yes	No	0	9	9
224	R:R:A361	R:R:K358	3.21	No	No	0	8	7
225	R:R:R228	R:R:R349	3.2	No	Yes	0	8	6
226	R:R:R349	R:R:R352	3.2	Yes	No	0	6	8
227	R:R:T215	R:R:V364	3.17	No	No	0	6	8
228	R:R:I225	R:R:V356	3.07	No	No	0	8	8
229	R:R:A152	R:R:Q68	3.03	No	No	0	8	8
230	R:R:F207	R:R:G368	3.01	Yes	No	6	9	7
231	R:R:F211	R:R:G368	3.01	Yes	No	6	8	7
232	R:R:G105	R:R:R104	3	No	No	0	5	4
233	R:R:G386	R:R:R381	3	No	Yes	0	3	4
234	R:R:L40	R:R:V36	2.98	No	No	0	5	4
235	R:R:L50	R:R:V46	2.98	No	No	0	5	5
236	R:R:L96	R:R:V92	2.98	No	No	0	7	7
237	R:R:L109	R:R:V113	2.98	No	No	0	6	6
238	R:R:L172	R:R:V112	2.98	No	No	0	5	8
239	R:R:L157	R:R:V153	2.98	No	No	0	5	5
240	R:R:L165	R:R:V161	2.98	No	No	0	5	5
241	R:R:L44	R:R:T48	2.95	No	No	0	7	9
242	R:R:F123	R:R:P210	2.89	No	No	0	7	9
243	R:R:G103	R:R:W100	2.81	No	Yes	0	8	9
244	R:R:A58	R:R:F423	2.77	No	No	0	9	9
245	R:R:A170	R:R:F198	2.77	No	Yes	0	8	7
246	R:R:A372	R:R:F207	2.77	No	Yes	0	7	9
247	R:R:A357	R:R:Y222	2.67	No	No	0	8	7
248	R:R:F81	R:R:V49	2.62	No	No	0	8	7
249	R:R:F164	R:R:V112	2.62	No	No	0	7	8
250	R:R:R99	R:R:T97	2.59	No	No	0	4	5
251	R:R:F102	R:R:T101	2.59	Yes	No	0	8	5
252	R:R:A382	R:R:W196	2.59	No	Yes	0	7	5
253	R:R:A383	R:R:W196	2.59	No	Yes	0	5	5
254	R:R:R421	R:R:T424	2.59	No	No	0	6	4
255	R:R:K355	R:R:R352	2.48	No	No	0	8	8
256	R:R:F192	R:R:L199	2.44	Yes	No	0	7	8
257	R:R:F208	R:R:L376	2.44	Yes	No	0	7	7
258	R:R:F423	R:R:L414	2.44	No	No	0	9	7
259	R:R:L233	R:R:R232	2.43	No	No	0	5	5
260	R:R:H385	R:R:H387	2.39	No	No	0	4	4
261	R:R:N195	R:R:Y197	2.33	No	No	0	6	5
262	R:R:G179	R:R:G180	2.11	No	No	0	5	2
263	R:R:C384	R:R:G386	1.96	No	No	0	7	3
264	R:R:A372	R:R:P373	1.87	No	No	0	7	9
265	R:R:G98	R:R:T97	1.82	No	No	0	7	5
266	R:R:A422	R:R:A58	1.79	No	No	0	9	9
267	R:R:G51	R:R:L50	1.71	No	No	0	9	5
268	R:R:A85	R:R:V49	1.7	No	No	0	6	7
269	R:R:A406	R:R:T48	1.68	No	No	0	7	9
270	R:R:C388	R:R:I380	1.64	No	No	0	8	7
271	R:R:S213	R:R:V126	1.62	No	No	0	8	8
272	R:R:A53	R:R:M56	1.61	No	No	0	6	7
273	R:R:A58	R:R:L426	1.58	No	Yes	0	9	8
274	R:R:I363	R:R:S359	1.55	No	No	0	8	9
275	R:R:I366	R:R:V362	1.54	No	No	0	7	8
276	R:R:I200	R:R:T201	1.52	No	No	0	7	6
277	R:R:L50	R:R:V49	1.49	No	No	0	5	7
278	R:R:L414	R:R:V410	1.49	No	No	0	7	7
279	R:R:D62	R:R:S63	1.47	No	No	0	8	8
280	R:R:L205	R:R:T209	1.47	No	No	0	6	7
281	R:R:K425	R:R:L426	1.41	No	Yes	0	6	8
282	R:R:L37	R:R:L40	1.38	No	No	0	5	5
283	R:R:L54	R:R:L57	1.38	No	No	0	8	7
284	R:R:L426	R:R:L57	1.38	Yes	No	0	8	7
285	R:R:E175	R:R:K108	1.35	Yes	No	0	5	7
286	R:R:D353	R:R:Q226	1.31	No	No	0	9	7
287	R:R:R99	R:R:T101	1.29	No	No	0	4	5
288	R:R:F123	R:R:L162	1.22	No	No	0	7	6
289	R:R:F164	R:R:L165	1.22	No	No	0	7	5
290	R:R:F211	R:R:L212	1.22	Yes	No	0	8	5
291	R:R:Q146	R:R:R143	1.17	No	No	0	8	7
292	R:R:L177	R:R:Y176	1.17	No	No	0	4	5
293	R:R:L223	R:R:Y222	1.17	No	No	0	5	7
294	R:R:H417	R:R:R421	1.13	No	No	0	5	6
295	R:R:E175	R:R:Y176	1.12	Yes	No	0	5	5
296	R:R:F348	R:R:R352	1.07	No	No	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.661	10	1	0
2	R:R:F71	5.76	4	0	6
3	R:R:L73	4.6	5	2	8
4	R:R:L76	6.716	5	2	9
5	R:R:D80	7.828	5	2	9
6	R:R:Y91	8.4	7	1	8
7	R:R:W100	8.74167	6	1	9
8	R:R:F102	7.7325	4	0	8
9	R:R:W110	5.62167	6	1	6
10	R:R:D114	7.7475	4	1	9
11	R:R:Y115	6.8425	4	1	9
12	R:R:I128	4.6025	4	2	9
13	R:R:W160	8.545	4	4	9
14	R:R:Y167	6.91143	7	1	8
15	R:R:W174	7.22	4	1	5
16	R:R:E175	6.495	4	0	5
17	R:R:Y189	7.29	4	1	4
18	R:R:F192	7.20167	6	1	7
19	R:R:F193	10.654	5	1	5
20	R:R:Y194	5.9575	4	1	6
21	R:R:W196	5.1225	4	0	5
22	R:R:F198	5.99667	6	1	7
23	R:R:E206	9.76	4	1	8
24	R:R:F207	6.43833	6	6	9
25	R:R:F208	4.2375	4	0	7
26	R:R:F211	4.8775	4	6	8
27	R:R:N218	5.05	4	5	9
28	R:R:R349	6.91	4	0	6
29	R:R:W371	8.26333	6	0	8
30	R:R:Y374	9.54	5	1	9
31	R:R:R381	8.002	5	1	4
32	R:R:F398	10.052	5	1	7
33	R:R:W399	6.5625	4	1	9
34	R:R:W402	9.15625	8	1	8
35	R:R:N408	8.326	5	2	9
36	R:R:Y412	5.60429	7	2	9
37	R:R:H416	5.6875	4	2	9
38	R:R:F419	5.174	5	2	9
39	R:R:L426	2.275	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W402	33.6521	7.08	Yes	Yes	1	0	8
2	R:R:I88	R:R:W402	11.797	17.62	No	Yes	0	9	8
3	R:R:V83	R:R:W402	49.6086	3.68	No	Yes	0	9	8
4	R:R:S405	R:R:V83	46.7041	8.08	No	No	0	9	9
5	R:R:D80	R:R:S405	46.5248	8.83	Yes	No	0	9	9
6	L:L:?1	R:R:E206	22.5303	9.73	Yes	Yes	1	0	8
7	R:R:E206	R:R:W371	77.0633	7.63	Yes	Yes	0	8	8
8	R:R:F367	R:R:W371	35.3553	7.02	No	Yes	0	9	8
9	R:R:F367	R:R:I125	34.6381	6.28	No	No	0	9	8
10	R:R:I125	R:R:Y412	33.2278	9.67	No	Yes	2	8	9
11	R:R:I128	R:R:Y412	51.2699	4.84	Yes	Yes	2	9	9
12	R:R:I128	R:R:L73	98.1235	4.28	Yes	Yes	2	9	8
13	L:L:?1	R:R:L401	15.4127	10.95	Yes	No	1	0	8
14	R:R:L401	R:R:W371	43.8953	15.94	No	Yes	0	8	8
15	R:R:N404	R:R:W371	100	6.78	No	Yes	0	9	8
16	R:R:N404	R:R:N408	98.6135	12.26	No	Yes	0	9	9
17	R:R:N408	R:R:Y412	36.2218	4.65	Yes	Yes	2	9	9
18	R:R:L76	R:R:N408	64.2204	10.98	Yes	Yes	2	9	9
19	R:R:I128	R:R:L76	50.1823	4.28	Yes	Yes	2	9	9
20	R:R:D80	R:R:L76	41.4929	8.14	Yes	Yes	2	9	9
21	R:R:L117	R:R:V83	16.5362	4.47	No	No	0	7	9
22	R:R:L117	R:R:L82	14.9226	6.92	No	No	0	7	6
23	R:R:F81	R:R:L82	13.2971	3.65	No	No	0	8	6
24	R:R:L76	R:R:N124	75.8322	5.49	Yes	No	0	9	8
25	R:R:N124	R:R:N75	73.4297	16.35	No	No	0	8	9
26	R:R:M156	R:R:N75	67.2145	11.22	No	No	0	9	9
27	R:R:F71	R:R:M156	65.9356	3.73	Yes	No	0	6	9
28	R:R:F419	R:R:L73	59.541	6.09	Yes	Yes	2	9	8
29	R:R:F419	R:R:F423	32.5046	3.22	Yes	No	0	9	9
30	R:R:A58	R:R:F423	22.8769	2.77	No	No	0	9	9
31	R:R:A58	R:R:L426	16.3987	1.58	No	Yes	0	9	8
32	R:R:F419	R:R:L65	13.0461	3.65	Yes	No	2	9	9
33	R:R:F419	R:R:N70	13.0461	7.25	Yes	No	2	9	9
34	R:R:A152	R:R:F71	58.0111	5.55	No	Yes	0	8	6
35	R:R:A152	R:R:Q68	56.6485	3.03	No	No	0	8	8
36	R:R:Q68	R:R:R151	55.274	4.67	No	No	0	8	7
37	R:R:L73	R:R:N69	22.5004	5.49	Yes	No	2	8	8
38	R:R:D131	R:R:N69	20.0741	6.73	No	No	0	9	8
39	R:R:D131	R:R:F72	10.0879	7.17	No	No	0	9	9
40	L:L:?1	R:R:D114	12.0839	6.9	Yes	Yes	1	0	9
41	R:R:D114	R:R:W110	10.554	6.7	Yes	Yes	1	9	6
42	R:R:L90	R:R:W110	10.5122	3.42	No	Yes	0	6	6
43	R:R:W110	R:R:W402	27.6878	3.75	Yes	Yes	1	6	8
44	R:R:F398	R:R:Y394	16.0521	5.16	Yes	No	0	7	4
45	R:R:W100	R:R:W110	27.0065	4.69	Yes	Yes	1	9	6
46	R:R:F102	R:R:W100	19.4048	15.03	Yes	Yes	0	8	9
47	L:L:?1	R:R:Y115	33.425	8.61	Yes	Yes	1	0	9
48	R:R:I171	R:R:Y115	36.8015	3.63	No	Yes	1	7	9
49	R:R:I171	R:R:V112	41.3853	4.61	No	No	0	7	8
50	R:R:E206	R:R:T119	21.9267	12.7	Yes	No	0	8	9
51	R:R:F123	R:R:T119	17.6358	5.19	No	No	0	7	9
52	R:R:F123	R:R:P210	11.1098	2.89	No	No	0	7	9
53	L:L:?1	R:R:T375	18.3948	5.83	Yes	No	0	0	8
54	R:R:F207	R:R:T375	18.6279	12.97	Yes	No	0	9	8
55	R:R:F207	R:R:F211	23.7495	7.5	Yes	Yes	6	9	8
56	R:R:F211	R:R:T215	19.1	7.78	Yes	No	0	8	6
57	R:R:T215	R:R:V364	16.7274	3.17	No	No	0	6	8
58	R:R:N218	R:R:V364	14.3429	4.43	Yes	No	0	9	8
59	R:R:Q145	R:R:R151	51.0668	14.02	No	No	0	6	7
60	R:R:Q145	R:R:S141	49.8297	5.78	No	No	0	6	5
61	R:R:R138	R:R:S141	48.3954	7.91	No	No	0	6	5
62	R:R:R138	R:R:T137	46.9491	3.88	No	No	0	6	8
63	R:R:F133	R:R:T137	12.2931	10.38	No	No	0	9	8
64	R:R:N224	R:R:T137	34.9429	4.39	No	No	0	7	8
65	R:R:F164	R:R:V112	29.8452	2.62	No	No	0	7	8
66	R:R:F164	R:R:G168	11.9704	9.03	No	No	0	7	6
67	L:L:?1	R:R:Y167	20.2295	6.62	Yes	Yes	1	0	8
68	R:R:F198	R:R:Y167	41.4749	4.13	Yes	Yes	1	7	8
69	R:R:F198	R:R:W174	23.7136	4.01	Yes	Yes	1	7	5
70	R:R:E191	R:R:W174	20.0143	14.17	No	Yes	0	8	5
71	R:R:E175	R:R:E191	17.8151	17.76	Yes	No	0	5	8
72	R:R:F198	R:R:N195	15.3051	4.83	Yes	No	1	7	6
73	L:L:?1	R:R:Y374	14.7314	9.27	Yes	Yes	1	0	9
74	R:R:M378	R:R:Y374	40.9789	17.96	No	Yes	1	8	9
75	R:R:F193	R:R:M378	11.4205	6.22	Yes	No	1	5	8
76	R:R:F193	R:R:Y394	17.0203	8.25	Yes	No	0	5	4
77	R:R:M378	R:R:R381	27.1201	7.44	No	Yes	1	8	4
78	R:R:F192	R:R:Y167	15.0421	5.16	Yes	Yes	1	7	8
79	R:R:H385	R:R:Y194	10.0341	5.44	No	Yes	0	4	6
80	R:R:N195	R:R:Y197	13.5481	2.33	No	No	0	6	5
81	R:R:W196	R:R:Y197	11.319	10.61	Yes	No	0	5	5
82	R:R:F207	R:R:F208	12.1556	5.36	Yes	Yes	0	9	7
83	R:R:N224	R:R:R227	33.5684	6.03	No	No	0	7	5
84	R:R:R227	R:R:R228	32.0026	4.26	No	No	0	5	8
85	R:R:R228	R:R:R349	30.413	3.2	No	Yes	0	8	6
86	R:R:R349	R:R:T229	15.6816	11.64	Yes	No	0	6	6
87	R:R:D353	R:R:T229	13.9843	8.67	No	No	0	9	6
88	R:R:L411	R:R:Y412	16.9904	3.52	No	Yes	0	9	9
89	R:R:I366	R:R:L411	11.3727	4.28	No	No	0	7	9
90	R:R:R381	R:R:V389	12.8548	5.23	Yes	No	0	4	5
91	R:R:G386	R:R:R381	12.8548	3	No	Yes	0	3	4
92	R:R:F164	R:R:L165	11.9704	1.22	No	No	0	7	5
93	R:R:F102	R:R:T101	11.6118	2.59	Yes	No	0	8	5
94	R:R:F398	R:R:W402	12.6038	10.02	Yes	Yes	1	7	8
95	R:R:E206	R:R:Y167	51.8377	8.98	Yes	Yes	1	8	8
96	R:R:Y115	R:R:Y167	10.3448	8.94	Yes	Yes	1	9	8
97	R:R:F207	R:R:W371	30.1799	7.02	Yes	Yes	0	9	8
98	R:R:F192	R:R:I171	10.1655	5.02	Yes	No	1	7	7
99	R:R:L401	R:R:Y374	28.1599	5.86	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D114	6.9	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y115	8.61	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:C118	7.17	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y167	6.62	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:E206	9.73	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y374	9.27	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:T375	5.83	1	Yes	No	0	8	0	1
L:L:?1	R:R:F398	14.45	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L401	10.95	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	7.08	1	Yes	Yes	0	8	0	1
R:R:V83	R:R:W402	3.68	0	No	Yes	9	8	2	1
R:R:C87	R:R:D114	6.22	0	No	Yes	9	9	2	1
R:R:I88	R:R:W402	17.62	0	No	Yes	9	8	2	1
R:R:W110	R:R:Y91	10.61	1	Yes	Yes	6	8	2	2
R:R:F398	R:R:Y91	12.38	1	Yes	Yes	7	8	1	2
R:R:W399	R:R:Y91	4.82	1	Yes	Yes	9	8	2	2
R:R:W402	R:R:Y91	8.68	1	Yes	Yes	8	8	1	2
R:R:D114	R:R:W110	6.7	1	Yes	Yes	9	6	1	2
R:R:W110	R:R:W402	3.75	1	Yes	Yes	6	8	2	1
R:R:D114	R:R:W402	11.17	1	Yes	Yes	9	8	1	1
R:R:Y115	R:R:Y167	8.94	1	Yes	Yes	9	8	1	1
R:R:I171	R:R:Y115	3.63	1	No	Yes	7	9	2	1
R:R:F192	R:R:Y115	6.19	1	Yes	Yes	7	9	2	1
R:R:E206	R:R:T119	12.7	1	Yes	No	8	9	1	2
R:R:L166	R:R:Y167	10.55	0	No	Yes	8	8	2	1
R:R:F192	R:R:Y167	5.16	1	Yes	Yes	7	8	2	1
R:R:F198	R:R:Y167	4.13	1	Yes	Yes	7	8	2	1
R:R:A202	R:R:Y167	4	1	No	Yes	9	8	2	1
R:R:E206	R:R:Y167	8.98	1	Yes	Yes	8	8	1	1
R:R:F192	R:R:I171	5.02	1	Yes	No	7	7	2	2
R:R:F192	R:R:F198	16.08	1	Yes	Yes	7	7	2	2
R:R:A202	R:R:F198	4.16	1	No	Yes	9	7	2	2
R:R:E206	R:R:W371	7.63	1	Yes	Yes	8	8	1	2
R:R:F207	R:R:W371	7.02	6	Yes	Yes	9	8	2	2
R:R:F207	R:R:T375	12.97	6	Yes	No	9	8	2	1
R:R:L401	R:R:W371	15.94	1	No	Yes	8	8	1	2
R:R:M378	R:R:Y374	17.96	1	No	Yes	8	9	2	1
R:R:S397	R:R:Y374	6.36	0	No	Yes	7	9	2	1
R:R:F398	R:R:Y374	8.25	1	Yes	Yes	7	9	1	1
R:R:L401	R:R:Y374	5.86	1	No	Yes	8	9	1	1
R:R:F398	R:R:Y394	5.16	1	Yes	No	7	4	1	2
R:R:F398	R:R:W402	10.02	1	Yes	Yes	7	8	1	1
R:R:W399	R:R:W402	11.25	1	Yes	Yes	9	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YN8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	260
Number of Links	296
Number of Hubs	39
Number of Links mediated by Hubs	150
Number of Communities	7
Number of Nodes involved in Communities	55
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	52913
Length Of Smallest Path	3
Average Path Length	12.8745
Length of Longest Path	34
Minimum Path Strength	1.145
Average Path Strength	7.02409
Maximum Path Strength	17.15
Minimum Path Correlation	0.7
Average Path Correlation	0.927558
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	53.5785
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0572
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cellular localization • neurotransmitter secretion • transport • secretion • export from cell • neurotransmitter transport • establishment of localization • localization • signal release from synapse • secretion by cell • signal release • establishment of localization in cell • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5N1
Sequence	>8YN8_nogp_Chain_R T A V L A A L M A L L I V A T V L G N A L V M L A F V A D S S L R T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R W T F G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R A V S Y R A Q Q G D T R R A V R K M L L V W V L A F L L Y G P A I L S W E Y L S G G S S I P E G H C Y A E F F Y N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D S F T Q R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C H G H C V P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F R R A F T K L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR0	Na	-	1.71	2025-06-18	To be published
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8TH3	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	AT118-H Nanobody	-	3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	9JH3	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	8YUV	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-	Gi1/β1/γ2	3	2024-06-05	doi.org/10.1002/advs.202310120
	8YUV (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-		3	2024-06-05	doi.org/10.1002/advs.202310120
	7F61	A	Amine	Histamine	H₃	Homo sapiens	PF-03654746	-	-	2.6	2022-10-26	doi.org/10.1038/s41467-022-33880-y
	8YN7	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN7 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YUU	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ1	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUU (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YN5	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-	Gi1/β1/γ2	2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-		2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb

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