psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D114	14.05	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y115	8.83	Yes	Yes	1	0	9
3	L:L:?1	R:R:C118	8.96	Yes	No	0	0	8
4	L:L:?1	R:R:E206	4.99	Yes	Yes	0	0	8
5	L:L:?1	R:R:Y374	17.65	Yes	Yes	1	0	9
6	L:L:?1	R:R:F398	26.36	Yes	Yes	1	0	7
7	L:L:?1	R:R:L401	11.72	Yes	No	1	0	8
8	L:L:?1	R:R:W402	11.79	Yes	Yes	1	0	8
9	R:R:M41	R:R:W399	6.98	No	No	0	7	9
10	R:R:I45	R:R:I88	4.42	No	No	0	7	9
11	R:R:I45	R:R:P89	6.77	No	No	0	7	9
12	R:R:F81	R:R:V49	3.93	No	No	0	8	7
13	R:R:D80	R:R:N52	6.73	Yes	No	0	9	9
14	R:R:N52	R:R:P409	11.4	No	No	0	9	9
15	R:R:A77	R:R:V55	5.09	No	No	0	9	9
16	R:R:P413	R:R:V55	7.07	No	No	0	9	9
17	R:R:F419	R:R:V55	3.93	Yes	No	0	9	9
18	R:R:I78	R:R:M56	4.37	No	No	0	8	7
19	R:R:F81	R:R:M56	12.44	No	No	0	8	7
20	R:R:F59	R:R:R66	13.9	No	No	0	8	8
21	R:R:F59	R:R:F71	12.86	No	Yes	0	8	6
22	R:R:F59	R:R:L74	19.49	No	No	0	8	8
23	R:R:A61	R:R:L426	4.73	No	No	0	7	8
24	R:R:D62	R:R:S64	8.83	Yes	No	2	8	7
25	R:R:D62	R:R:L65	10.86	Yes	No	2	8	9
26	R:R:D62	R:R:R421	5.96	Yes	No	2	8	6
27	R:R:A422	R:R:D62	4.63	No	Yes	0	9	8
28	R:R:R421	R:R:S64	3.95	No	No	2	6	7
29	R:R:L65	R:R:N70	8.24	No	Yes	2	9	9
30	R:R:F419	R:R:L65	4.87	Yes	No	2	9	9
31	R:R:N70	R:R:T67	10.24	Yes	No	0	9	8
32	R:R:Q146	R:R:T67	8.5	No	No	0	8	8
33	R:R:Q68	R:R:R151	7.01	No	No	0	8	7
34	R:R:K155	R:R:Q68	5.42	No	No	0	7	8
35	R:R:L73	R:R:N69	5.49	Yes	No	2	8	8
36	R:R:D131	R:R:N69	6.73	No	No	0	9	8
37	R:R:H416	R:R:N69	7.65	Yes	No	2	9	8
38	R:R:H416	R:R:N70	5.1	Yes	Yes	2	9	9
39	R:R:F419	R:R:N70	7.25	Yes	Yes	2	9	9
40	R:R:F71	R:R:T149	5.19	Yes	No	0	6	6
41	R:R:A152	R:R:F71	4.16	No	Yes	0	8	6
42	R:R:F71	R:R:M156	3.73	Yes	No	0	6	9
43	R:R:F72	R:R:L127	18.27	No	No	3	9	8
44	R:R:D131	R:R:F72	7.17	No	No	0	9	9
45	R:R:F72	R:R:K155	7.44	No	No	3	9	7
46	R:R:I128	R:R:L73	4.28	No	Yes	2	9	8
47	R:R:H416	R:R:L73	3.86	Yes	Yes	2	9	8
48	R:R:F419	R:R:L73	6.09	Yes	Yes	2	9	8
49	R:R:I78	R:R:L74	7.14	No	No	0	8	8
50	R:R:N124	R:R:N75	16.35	No	No	0	8	9
51	R:R:M156	R:R:N75	11.22	No	No	0	9	9
52	R:R:N75	R:R:W160	12.43	No	No	0	9	9
53	R:R:L76	R:R:N124	8.24	No	No	0	9	8
54	R:R:L76	R:R:N408	10.98	No	Yes	0	9	9
55	R:R:S120	R:R:S79	6.52	No	No	0	8	8
56	R:R:D80	R:R:S121	5.89	Yes	No	0	9	9
57	R:R:D80	R:R:S405	10.31	Yes	No	0	9	9
58	R:R:D80	R:R:N408	8.08	Yes	Yes	0	9	9
59	R:R:L117	R:R:L82	5.54	No	No	0	7	6
60	R:R:L117	R:R:V83	4.47	No	No	0	7	9
61	R:R:S405	R:R:V83	8.08	No	No	0	9	9
62	R:R:G84	R:R:I88	5.29	No	No	0	9	9
63	R:R:F86	R:R:L90	6.09	No	No	0	6	6
64	R:R:F86	R:R:V113	6.55	No	No	0	6	6
65	R:R:C87	R:R:D114	6.22	No	Yes	0	9	9
66	R:R:I88	R:R:W402	12.92	No	Yes	0	9	8
67	R:R:Y91	R:R:Y94	13.9	Yes	No	0	8	6
68	R:R:V95	R:R:Y91	3.79	No	Yes	0	6	8
69	R:R:W110	R:R:Y91	10.61	Yes	Yes	0	6	8
70	R:R:E395	R:R:Y91	6.73	No	Yes	0	6	8
71	R:R:F398	R:R:Y91	11.35	Yes	Yes	1	7	8
72	R:R:W399	R:R:Y91	5.79	No	Yes	1	9	8
73	R:R:W402	R:R:Y91	8.68	Yes	Yes	1	8	8
74	R:R:F102	R:R:P93	5.78	Yes	No	0	8	7
75	R:R:W100	R:R:Y94	3.86	Yes	No	0	9	6
76	R:R:H187	R:R:Y94	4.36	No	No	0	3	6
77	R:R:R99	R:R:T97	3.88	No	No	0	4	5
78	R:R:R99	R:R:T101	6.47	No	No	0	4	5
79	R:R:G186	R:R:R99	4.5	No	No	0	3	4
80	R:R:F102	R:R:W100	9.02	Yes	Yes	0	8	9
81	R:R:C107	R:R:W100	5.22	No	Yes	4	9	9
82	R:R:W100	R:R:W110	6.56	Yes	Yes	0	9	6
83	R:R:C188	R:R:W100	16.98	No	Yes	4	9	9
84	R:R:F102	R:R:L106	4.87	Yes	No	0	8	5
85	R:R:K108	R:R:R104	14.85	No	Yes	1	7	4
86	R:R:E175	R:R:R104	4.65	Yes	Yes	1	5	4
87	R:R:I183	R:R:R104	3.76	No	Yes	1	4	4
88	R:R:E191	R:R:R104	5.82	Yes	Yes	1	8	4
89	R:R:C107	R:R:C188	7.28	No	No	4	9	9
90	R:R:E175	R:R:K108	4.05	Yes	No	1	5	7
91	R:R:D114	R:R:W110	7.82	Yes	Yes	0	9	6
92	R:R:I171	R:R:L111	4.28	Yes	No	0	7	7
93	R:R:L172	R:R:V112	4.47	No	No	0	5	8
94	R:R:D114	R:R:W402	6.7	Yes	Yes	1	9	8
95	R:R:Y115	R:R:Y167	15.89	Yes	Yes	1	9	8
96	R:R:I171	R:R:Y115	6.04	Yes	Yes	1	7	9
97	R:R:F192	R:R:Y115	5.16	Yes	Yes	1	7	9
98	R:R:F123	R:R:T119	5.19	No	No	0	7	9
99	R:R:E206	R:R:T119	5.64	Yes	No	0	8	9
100	R:R:S120	R:R:W160	9.88	No	No	0	8	9
101	R:R:A122	R:R:W371	5.19	No	Yes	0	9	8
102	R:R:N124	R:R:V159	7.39	No	No	0	8	8
103	R:R:F367	R:R:I125	3.77	Yes	No	0	9	8
104	R:R:I125	R:R:N408	4.25	No	Yes	0	8	9
105	R:R:I125	R:R:Y412	8.46	No	Yes	0	8	9
106	R:R:K155	R:R:L127	4.23	No	No	3	7	8
107	R:R:I128	R:R:R132	6.26	No	No	2	9	9
108	R:R:I128	R:R:Y412	8.46	No	Yes	2	9	9
109	R:R:S129	R:R:V214	6.46	No	No	0	9	9
110	R:R:F217	R:R:S129	3.96	Yes	No	0	8	9
111	R:R:N218	R:R:S129	4.47	No	No	0	9	9
112	R:R:L134	R:R:Y130	14.07	No	No	0	5	7
113	R:R:F217	R:R:Y130	9.28	Yes	No	0	8	7
114	R:R:D131	R:R:Y142	11.49	No	No	0	9	9
115	R:R:R132	R:R:Y412	5.14	No	Yes	2	9	9
116	R:R:F133	R:R:T137	14.27	No	No	0	9	8
117	R:R:F133	R:R:F217	12.86	No	Yes	0	9	8
118	R:R:F133	R:R:S220	3.96	No	No	0	9	8
119	R:R:L134	R:R:R138	7.29	No	No	0	5	6
120	R:R:S135	R:R:Y142	8.9	No	No	0	9	9
121	R:R:N224	R:R:V136	4.43	No	No	0	7	8
122	R:R:Q145	R:R:S141	8.66	No	No	0	6	5
123	R:R:Q145	R:R:R151	14.02	No	No	0	6	7
124	R:R:D148	R:R:R151	15.48	No	No	0	8	7
125	R:R:R150	R:R:V153	10.46	No	No	0	7	5
126	R:R:L158	R:R:L162	6.92	No	No	0	4	6
127	R:R:F164	R:R:G168	4.52	No	No	5	7	6
128	R:R:F164	R:R:P169	4.33	No	No	5	7	8
129	R:R:L166	R:R:Y167	10.55	No	Yes	0	8	8
130	R:R:L166	R:R:L205	4.15	No	No	0	8	6
131	R:R:F192	R:R:Y167	4.13	Yes	Yes	1	7	8
132	R:R:A202	R:R:Y167	4	No	Yes	0	9	8
133	R:R:E206	R:R:Y167	15.71	Yes	Yes	0	8	8
134	R:R:G168	R:R:P169	4.06	No	No	5	6	8
135	R:R:A170	R:R:F198	4.16	No	Yes	0	8	7
136	R:R:F192	R:R:I171	3.77	Yes	Yes	1	7	7
137	R:R:S178	R:R:W174	6.18	No	Yes	0	3	5
138	R:R:E191	R:R:W174	7.63	Yes	Yes	1	8	5
139	R:R:N195	R:R:W174	6.78	No	Yes	1	6	5
140	R:R:F198	R:R:W174	4.01	Yes	Yes	1	7	5
141	R:R:E175	R:R:S181	8.62	Yes	No	1	5	4
142	R:R:E175	R:R:E191	6.34	Yes	Yes	1	5	8
143	R:R:E191	R:R:S181	4.31	Yes	No	1	8	4
144	R:R:I183	R:R:Y189	6.04	No	Yes	0	4	4
145	R:R:E191	R:R:I183	9.56	Yes	No	1	8	4
146	R:R:P184	R:R:Y189	4.17	No	Yes	0	3	4
147	R:R:E185	R:R:G186	4.91	No	No	0	1	3
148	R:R:H187	R:R:Y189	5.44	No	Yes	0	3	4
149	R:R:F193	R:R:Y189	14.44	Yes	Yes	0	5	4
150	R:R:A190	R:R:F192	8.32	No	Yes	0	7	7
151	R:R:F192	R:R:F198	19.29	Yes	Yes	1	7	7
152	R:R:F193	R:R:Y194	12.38	Yes	No	1	5	6
153	R:R:F193	R:R:M378	3.73	Yes	No	1	5	8
154	R:R:F193	R:R:R381	18.17	Yes	Yes	1	5	4
155	R:R:F193	R:R:Y394	8.25	Yes	No	0	5	4
156	R:R:R381	R:R:Y194	7.2	Yes	No	1	4	6
157	R:R:H385	R:R:Y194	5.44	No	No	0	4	6
158	R:R:F198	R:R:N195	4.83	Yes	No	1	7	6
159	R:R:W196	R:R:Y197	11.58	No	No	0	5	5
160	R:R:I200	R:R:I379	4.42	No	No	0	7	6
161	R:R:F208	R:R:T204	7.78	Yes	No	0	7	6
162	R:R:E206	R:R:W371	8.72	Yes	Yes	0	8	8
163	R:R:F207	R:R:F208	6.43	Yes	Yes	0	9	7
164	R:R:F207	R:R:F211	7.5	Yes	Yes	0	9	8
165	R:R:F207	R:R:F367	4.29	Yes	Yes	1	9	9
166	R:R:F207	R:R:W371	7.02	Yes	Yes	1	9	8
167	R:R:F207	R:R:T375	7.78	Yes	No	0	9	8
168	R:R:F211	R:R:T215	7.78	Yes	No	0	8	6
169	R:R:F211	R:R:G368	4.52	Yes	No	0	8	7
170	R:R:F216	R:R:F217	5.36	No	Yes	0	5	8
171	R:R:F216	R:R:S220	7.93	No	No	0	5	8
172	R:R:L360	R:R:N218	5.49	No	No	0	8	9
173	R:R:N218	R:R:V364	4.43	No	No	0	9	8
174	R:R:Q226	R:R:Y222	14.65	No	No	0	7	7
175	R:R:N224	R:R:R227	4.82	No	No	0	7	5
176	R:R:D353	R:R:I225	5.6	No	No	0	9	8
177	R:R:R227	R:R:R230	5.33	No	No	0	5	6
178	R:R:R349	R:R:T229	11.64	Yes	No	0	6	6
179	R:R:D353	R:R:T229	7.23	No	No	0	9	6
180	R:R:A236	R:R:R232	5.53	No	No	0	3	5
181	R:R:R232	R:R:R349	7.46	No	Yes	0	5	6
182	R:R:L233	R:R:Q346	3.99	No	No	0	5	5
183	R:R:Q346	R:R:T345	4.25	No	No	0	5	7
184	R:R:F348	R:R:S351	3.96	No	No	0	4	6
185	R:R:R349	R:R:R352	4.26	Yes	No	0	6	8
186	R:R:I363	R:R:Y412	6.04	No	Yes	0	8	9
187	R:R:I366	R:R:L411	4.28	No	No	0	7	9
188	R:R:F367	R:R:W371	8.02	Yes	Yes	1	9	8
189	R:R:C370	R:R:N404	11.02	No	No	0	8	9
190	R:R:L401	R:R:W371	17.08	No	Yes	1	8	8
191	R:R:N404	R:R:W371	7.91	No	Yes	0	9	8
192	R:R:M378	R:R:Y374	17.96	No	Yes	1	8	9
193	R:R:S397	R:R:Y374	6.36	No	Yes	0	7	9
194	R:R:F398	R:R:Y374	9.28	Yes	Yes	1	7	9
195	R:R:L401	R:R:Y374	5.86	No	Yes	1	8	9
196	R:R:L377	R:R:S397	6.01	No	No	0	7	7
197	R:R:M378	R:R:R381	4.96	No	Yes	1	8	4
198	R:R:R381	R:R:V389	5.23	Yes	No	0	4	5
199	R:R:C384	R:R:C388	7.28	No	No	0	7	8
200	R:R:P390	R:R:Y392	8.34	No	No	6	7	3
201	R:R:P390	R:R:W393	16.21	No	No	6	7	6
202	R:R:W393	R:R:Y392	7.72	No	No	6	6	3
203	R:R:E395	R:R:Y394	6.73	No	No	0	6	4
204	R:R:F398	R:R:Y394	5.16	Yes	No	0	7	4
205	R:R:F398	R:R:W402	9.02	Yes	Yes	1	7	8
206	R:R:W399	R:R:W402	11.25	No	Yes	1	9	8
207	R:R:N404	R:R:N408	10.9	No	Yes	0	9	9
208	R:R:L411	R:R:V407	4.47	No	No	0	9	7
209	R:R:H416	R:R:S418	5.58	Yes	No	0	9	8
210	R:R:F419	R:R:H416	4.53	Yes	Yes	2	9	9
211	R:R:G84	R:R:T48	3.64	No	No	0	9	9
212	R:R:L158	R:R:R154	3.64	No	No	0	4	3
213	R:R:K108	R:R:Y176	3.58	No	No	0	7	5
214	R:R:D148	R:R:R150	3.57	No	No	0	8	7
215	R:R:P93	R:R:V92	3.53	No	No	0	7	7
216	R:R:P210	R:R:V126	3.53	Yes	No	0	9	8
217	R:R:P390	R:R:V389	3.53	No	No	0	7	5
218	R:R:L411	R:R:Y412	3.52	No	Yes	0	9	9
219	R:R:P210	R:R:T209	3.5	Yes	No	0	9	7
220	R:R:L90	R:R:W110	3.42	No	Yes	0	6	6
221	R:R:L116	R:R:W160	3.42	No	No	0	8	9
222	R:R:H417	R:R:R420	3.39	No	No	0	5	9
223	R:R:A163	R:R:T119	3.36	No	No	0	8	9
224	R:R:L400	R:R:P373	3.28	No	No	0	9	9
225	R:R:S135	R:R:V136	3.23	No	No	0	9	8
226	R:R:F419	R:R:F423	3.22	Yes	Yes	0	9	9
227	R:R:S203	R:R:T375	3.2	No	No	0	8	8
228	R:R:R228	R:R:R349	3.2	No	Yes	0	8	6
229	R:R:S343	R:R:T345	3.2	No	No	0	3	7
230	R:R:T215	R:R:V364	3.17	No	No	0	6	8
231	R:R:I171	R:R:V112	3.07	Yes	No	0	7	8
232	R:R:I221	R:R:V136	3.07	No	No	0	9	8
233	R:R:G386	R:R:R381	3	No	Yes	0	3	4
234	R:R:L96	R:R:V92	2.98	No	No	0	7	7
235	R:R:L157	R:R:V153	2.98	No	No	0	5	5
236	R:R:L360	R:R:V356	2.98	No	No	0	8	8
237	R:R:L44	R:R:T48	2.95	No	No	0	7	9
238	R:R:I221	R:R:I225	2.94	No	No	0	9	8
239	R:R:F123	R:R:P210	2.89	No	Yes	0	7	9
240	R:R:F367	R:R:P210	2.89	Yes	Yes	0	9	9
241	R:R:G103	R:R:W100	2.81	No	Yes	0	8	9
242	R:R:A58	R:R:F423	2.77	No	Yes	0	9	9
243	R:R:A372	R:R:F207	2.77	No	Yes	0	7	9
244	R:R:L233	R:R:L350	2.77	No	No	0	5	6
245	R:R:A357	R:R:Y222	2.67	No	No	0	8	7
246	R:R:F164	R:R:V112	2.62	No	No	0	7	8
247	R:R:F102	R:R:T101	2.59	Yes	No	0	8	5
248	R:R:A382	R:R:W196	2.59	No	No	0	7	5
249	R:R:A383	R:R:W196	2.59	No	No	0	5	5
250	R:R:F208	R:R:I379	2.51	Yes	No	0	7	6
251	R:R:K355	R:R:R352	2.48	No	No	0	8	8
252	R:R:F86	R:R:L109	2.44	No	No	0	6	6
253	R:R:F192	R:R:L199	2.44	Yes	No	0	7	8
254	R:R:F423	R:R:L414	2.44	Yes	No	0	9	7
255	R:R:L414	R:R:R420	2.43	No	No	0	7	9
256	R:R:D234	R:R:R230	2.38	No	No	0	4	6
257	R:R:N195	R:R:Y197	2.33	No	No	0	6	5
258	R:R:G179	R:R:G180	2.11	No	No	0	5	2
259	R:R:C384	R:R:G386	1.96	No	No	0	7	3
260	R:R:A372	R:R:P373	1.87	No	No	0	7	9
261	R:R:G98	R:R:T97	1.82	No	No	0	7	5
262	R:R:G51	R:R:L50	1.71	No	No	0	9	5
263	R:R:A85	R:R:V49	1.7	No	No	0	6	7
264	R:R:A406	R:R:T48	1.68	No	No	0	7	9
265	R:R:D234	R:R:G235	1.68	No	No	0	4	4
266	R:R:G147	R:R:Q146	1.64	No	No	0	6	8
267	R:R:L165	R:R:P169	1.64	No	No	0	5	8
268	R:R:C388	R:R:I380	1.64	No	No	0	8	7
269	R:R:S213	R:R:V126	1.62	No	No	0	8	8
270	R:R:A53	R:R:M56	1.61	No	No	0	6	7
271	R:R:A58	R:R:L426	1.58	No	No	0	9	8
272	R:R:I363	R:R:S359	1.55	No	No	0	8	9
273	R:R:I366	R:R:V362	1.54	No	No	0	7	8
274	R:R:I200	R:R:T201	1.52	No	No	0	7	6
275	R:R:A236	R:R:Q346	1.52	No	No	0	3	5
276	R:R:G105	R:R:R104	1.5	No	Yes	0	5	4
277	R:R:L177	R:R:S173	1.5	No	No	0	4	6
278	R:R:L50	R:R:V46	1.49	No	No	0	5	5
279	R:R:L165	R:R:V161	1.49	No	No	0	5	5
280	R:R:L414	R:R:V410	1.49	No	No	0	7	7
281	R:R:E191	R:R:S182	1.44	Yes	No	0	8	5
282	R:R:L427	R:R:L54	1.38	No	No	0	8	8
283	R:R:L426	R:R:L57	1.38	No	No	0	8	7
284	R:R:L219	R:R:L223	1.38	No	No	0	4	5
285	R:R:D353	R:R:Q226	1.31	No	No	0	9	7
286	R:R:F423	R:R:L54	1.22	Yes	No	0	9	8
287	R:R:F123	R:R:L162	1.22	No	No	0	7	6
288	R:R:F208	R:R:L376	1.22	Yes	No	0	7	7
289	R:R:F211	R:R:L212	1.22	Yes	No	0	8	5
290	R:R:L231	R:R:R227	1.21	No	No	0	5	5
291	R:R:L223	R:R:Y222	1.17	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	13.0438	8	1	0
2	R:R:D62	7.57	4	2	8
3	R:R:N70	7.7075	4	2	9
4	R:R:F71	6.485	4	0	6
5	R:R:L73	4.93	4	2	8
6	R:R:D80	7.7525	4	0	9
7	R:R:Y91	8.69286	7	1	8
8	R:R:W100	7.40833	6	4	9
9	R:R:F102	5.565	4	0	8
10	R:R:R104	6.116	5	1	4
11	R:R:W110	7.1025	4	0	6
12	R:R:D114	8.6975	4	1	9
13	R:R:Y115	8.98	4	1	9
14	R:R:Y167	10.056	5	1	8
15	R:R:I171	4.29	4	1	7
16	R:R:W174	6.15	4	1	5
17	R:R:E175	5.915	4	1	5
18	R:R:Y189	7.5225	4	0	4
19	R:R:E191	5.85	6	1	8
20	R:R:F192	7.185	6	1	7
21	R:R:F193	11.394	5	1	5
22	R:R:F198	8.0725	4	1	7
23	R:R:E206	8.765	4	0	8
24	R:R:F207	5.965	6	1	9
25	R:R:F208	4.485	4	0	7
26	R:R:P210	3.2025	4	0	9
27	R:R:F211	5.255	4	0	8
28	R:R:F217	7.865	4	0	8
29	R:R:R349	6.64	4	0	6
30	R:R:F367	4.7425	4	1	9
31	R:R:W371	8.99	6	1	8
32	R:R:Y374	11.422	5	1	9
33	R:R:R381	7.712	5	1	4
34	R:R:F398	12.234	5	1	7
35	R:R:W402	10.06	6	1	8
36	R:R:N408	8.5525	4	0	9
37	R:R:Y412	6.324	5	2	9
38	R:R:H416	5.344	5	2	9
39	R:R:F419	4.98167	6	2	9
40	R:R:F423	2.4125	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W402	23.7623	11.79	Yes	Yes	1	0	8
2	R:R:I88	R:R:W402	15.0186	12.92	No	Yes	0	9	8
3	L:L:?1	R:R:E206	43.7811	4.99	Yes	Yes	0	0	8
4	R:R:E206	R:R:W371	71.5068	8.72	Yes	Yes	0	8	8
5	R:R:N404	R:R:W371	33.1478	7.91	No	Yes	0	9	8
6	R:R:N404	R:R:N408	31.9808	10.9	No	Yes	0	9	9
7	R:R:L76	R:R:N408	34.3059	10.98	No	Yes	0	9	9
8	R:R:L76	R:R:N124	32.7618	8.24	No	No	0	9	8
9	R:R:N124	R:R:N75	29.6468	16.35	No	No	0	8	9
10	R:R:M156	R:R:N75	21.7021	11.22	No	No	0	9	9
11	R:R:F71	R:R:M156	20.0862	3.73	Yes	No	0	6	9
12	R:R:F59	R:R:F71	15.1847	12.86	No	Yes	0	8	6
13	R:R:F59	R:R:L74	11.8722	19.49	No	No	0	8	8
14	R:R:I78	R:R:L74	10.2024	7.14	No	No	0	8	8
15	L:L:?1	R:R:L401	39.2208	11.72	Yes	No	1	0	8
16	R:R:L401	R:R:W371	62.8215	17.08	No	Yes	1	8	8
17	R:R:D80	R:R:N408	13.5329	8.08	Yes	Yes	0	9	9
18	R:R:F367	R:R:W371	77.8895	8.02	Yes	Yes	1	9	8
19	R:R:F367	R:R:I125	94.322	3.77	Yes	No	0	9	8
20	R:R:I125	R:R:Y412	100	8.46	No	Yes	0	8	9
21	R:R:I128	R:R:Y412	92.6523	8.46	No	Yes	2	9	9
22	R:R:I128	R:R:L73	92.0463	4.28	No	Yes	2	9	8
23	R:R:F419	R:R:L73	34.3597	6.09	Yes	Yes	2	9	8
24	R:R:F419	R:R:F423	18.9057	3.22	Yes	Yes	0	9	9
25	R:R:L73	R:R:N69	56.6273	5.49	Yes	No	2	8	8
26	R:R:D131	R:R:N69	61.1338	6.73	No	No	0	9	8
27	R:R:D131	R:R:F72	18.0484	7.17	No	No	0	9	9
28	R:R:F72	R:R:K155	14.8211	7.44	No	No	3	9	7
29	R:R:K155	R:R:Q68	13.2457	5.42	No	No	0	7	8
30	R:R:Q68	R:R:R151	11.6208	7.01	No	No	0	8	7
31	L:L:?1	R:R:D114	35.1946	14.05	Yes	Yes	1	0	9
32	R:R:D114	R:R:W110	32.6855	7.82	Yes	Yes	0	9	6
33	L:L:?1	R:R:F398	13.1245	26.36	Yes	Yes	1	0	7
34	R:R:F398	R:R:Y91	13.0167	11.35	Yes	Yes	1	7	8
35	R:R:Y91	R:R:Y94	10.1172	13.9	Yes	No	0	8	6
36	R:R:W100	R:R:W110	26.3028	6.56	Yes	Yes	0	9	6
37	R:R:F102	R:R:W100	21.9669	9.02	Yes	Yes	0	8	9
38	R:R:F102	R:R:T101	12.1145	2.59	Yes	No	0	8	5
39	R:R:R99	R:R:T101	10.1172	6.47	No	No	0	4	5
40	L:L:?1	R:R:Y115	21.3564	8.83	Yes	Yes	1	0	9
41	R:R:F192	R:R:F198	17.5861	19.29	Yes	Yes	1	7	7
42	R:R:F198	R:R:W174	10.6872	4.01	Yes	Yes	1	7	5
43	R:R:E191	R:R:W174	10.2967	7.63	Yes	Yes	1	8	5
44	R:R:M378	R:R:Y374	20.5799	17.96	No	Yes	1	8	9
45	R:R:I171	R:R:Y115	22.106	6.04	Yes	Yes	1	7	9
46	R:R:I171	R:R:V112	23.4481	3.07	Yes	No	0	7	8
47	R:R:E206	R:R:Y167	34.0006	15.71	Yes	Yes	0	8	8
48	R:R:F207	R:R:W371	31.8416	7.02	Yes	Yes	1	9	8
49	R:R:F207	R:R:F211	30.9439	7.5	Yes	Yes	0	9	8
50	R:R:F211	R:R:T215	26.2444	7.78	Yes	No	0	8	6
51	R:R:T215	R:R:V364	24.66	3.17	No	No	0	6	8
52	R:R:N218	R:R:V364	23.0666	4.43	No	No	0	9	8
53	R:R:N218	R:R:S129	18.412	4.47	No	No	0	9	9
54	R:R:F217	R:R:S129	15.1443	3.96	Yes	No	0	8	9
55	R:R:D131	R:R:Y142	44.5801	11.49	No	No	0	9	9
56	R:R:S135	R:R:Y142	43.1438	8.9	No	No	0	9	9
57	R:R:S135	R:R:V136	41.6985	3.23	No	No	0	9	8
58	R:R:F164	R:R:V112	16.9622	2.62	No	No	0	7	8
59	R:R:F164	R:R:P169	10.189	4.33	No	No	5	7	8
60	R:R:M378	R:R:R381	10.8712	4.96	No	Yes	1	8	4
61	R:R:F207	R:R:F208	10.0139	6.43	Yes	Yes	0	9	7
62	R:R:I221	R:R:V136	31.496	3.07	No	No	0	9	8
63	R:R:I221	R:R:I225	30.154	2.94	No	No	0	9	8
64	R:R:D353	R:R:I225	28.8029	5.6	No	No	0	9	8
65	R:R:D353	R:R:T229	19.6418	7.23	No	No	0	9	6
66	R:R:R349	R:R:T229	18.0529	11.64	Yes	No	0	6	6
67	R:R:R232	R:R:R349	11.6073	7.46	No	Yes	0	5	6
68	R:R:F192	R:R:Y167	23.0666	4.13	Yes	Yes	1	7	8
69	R:R:L401	R:R:Y374	23.4122	5.86	No	Yes	1	8	9
70	R:R:I125	R:R:N408	17.3033	4.25	No	Yes	0	8	9
71	R:R:F207	R:R:F367	16.9352	4.29	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D114	14.05	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y115	8.83	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:C118	8.96	1	Yes	No	0	8	0	1
L:L:?1	R:R:E206	4.99	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y374	17.65	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F398	26.36	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L401	11.72	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	11.79	1	Yes	Yes	0	8	0	1
R:R:C87	R:R:D114	6.22	0	No	Yes	9	9	2	1
R:R:I88	R:R:W402	12.92	0	No	Yes	9	8	2	1
R:R:W110	R:R:Y91	10.61	0	Yes	Yes	6	8	2	2
R:R:F398	R:R:Y91	11.35	1	Yes	Yes	7	8	1	2
R:R:W399	R:R:Y91	5.79	1	No	Yes	9	8	2	2
R:R:W402	R:R:Y91	8.68	1	Yes	Yes	8	8	1	2
R:R:D114	R:R:W110	7.82	1	Yes	Yes	9	6	1	2
R:R:D114	R:R:W402	6.7	1	Yes	Yes	9	8	1	1
R:R:Y115	R:R:Y167	15.89	1	Yes	Yes	9	8	1	2
R:R:I171	R:R:Y115	6.04	1	Yes	Yes	7	9	2	1
R:R:F192	R:R:Y115	5.16	1	Yes	Yes	7	9	2	1
R:R:E206	R:R:T119	5.64	0	Yes	No	8	9	1	2
R:R:F192	R:R:Y167	4.13	1	Yes	Yes	7	8	2	2
R:R:E206	R:R:Y167	15.71	0	Yes	Yes	8	8	1	2
R:R:F192	R:R:I171	3.77	1	Yes	Yes	7	7	2	2
R:R:E206	R:R:W371	8.72	0	Yes	Yes	8	8	1	2
R:R:L401	R:R:W371	17.08	1	No	Yes	8	8	1	2
R:R:M378	R:R:Y374	17.96	1	No	Yes	8	9	2	1
R:R:S397	R:R:Y374	6.36	0	No	Yes	7	9	2	1
R:R:F398	R:R:Y374	9.28	1	Yes	Yes	7	9	1	1
R:R:L401	R:R:Y374	5.86	1	No	Yes	8	9	1	1
R:R:F398	R:R:Y394	5.16	1	Yes	No	7	4	1	2
R:R:F398	R:R:W402	9.02	1	Yes	Yes	7	8	1	1
R:R:W399	R:R:W402	11.25	1	No	Yes	9	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YN5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.73
Number of Linked Nodes	259
Number of Links	291
Number of Hubs	40
Number of Links mediated by Hubs	146
Number of Communities	6
Number of Nodes involved in Communities	52
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	51593
Length Of Smallest Path	3
Average Path Length	13.2375
Length of Longest Path	32
Minimum Path Strength	1.275
Average Path Strength	7.58909
Maximum Path Strength	20.205
Minimum Path Correlation	0.7
Average Path Correlation	0.92935
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	53.5988
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0386
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cellular localization • neurotransmitter secretion • transport • secretion • export from cell • neurotransmitter transport • establishment of localization • localization • signal release from synapse • secretion by cell • signal release • establishment of localization in cell • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • presynapse • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	1H-Imidazole-4-ethanamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5N1
Sequence	>8YN5_nogp_Chain_R T A V L A A L M A L L I V A T V L G N A L V M L A F V A D S S L R T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R W T F G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R A V S Y R A Q Q G D T R R A V R K M L L V W V L A F L L Y G P A I L S W E Y L S G G S S I P E G H C Y A E F F Y N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G A S F T Q R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C H G H C V P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F R R A F T K L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR0	Na	-	1.71	2025-06-18	To be published
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8TH3	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	AT118-H Nanobody	-	3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	9JH3	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	8YUV	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-	Gi1/β1/γ2	3	2024-06-05	doi.org/10.1002/advs.202310120
	8YUV (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-		3	2024-06-05	doi.org/10.1002/advs.202310120
	7F61	A	Amine	Histamine	H₃	Homo sapiens	PF-03654746	-	-	2.6	2022-10-26	doi.org/10.1038/s41467-022-33880-y
	8YN7	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN7 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YUU	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ1	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUU (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YN5	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-	Gi1/β1/γ2	2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-		2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb

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