psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D94	6.13	Yes	Yes	1	0	8
2	L:L:?1	R:R:Y95	15.23	Yes	Yes	0	0	8
3	L:L:?1	R:R:C98	3.59	Yes	No	1	0	8
4	L:L:?1	R:R:E182	5.99	Yes	Yes	1	0	8
5	L:L:?1	R:R:W316	5.79	Yes	Yes	1	0	9
6	L:L:?1	R:R:Y319	4.64	Yes	Yes	1	0	7
7	L:L:?1	R:R:F344	14.45	Yes	Yes	1	0	6
8	L:L:?1	R:R:Q347	14.29	Yes	No	1	0	8
9	L:L:?1	R:R:W348	8.37	Yes	Yes	1	0	8
10	R:R:S11	R:R:T14	4.8	No	No	0	7	5
11	R:R:F78	R:R:R15	6.41	No	No	0	5	3
12	R:R:F20	R:R:F21	4.29	No	No	0	4	4
13	R:R:I73	R:R:M22	10.2	No	No	0	6	7
14	R:R:L77	R:R:M22	7.07	No	No	0	6	7
15	R:R:M22	R:R:W345	10.47	No	Yes	0	7	8
16	R:R:I73	R:R:S23	3.1	No	No	0	6	5
17	R:R:A26	R:R:I69	4.87	No	Yes	0	7	8
18	R:R:F27	R:R:L31	4.87	No	No	0	5	4
19	R:R:G65	R:R:I29	3.53	No	No	0	8	8
20	R:R:I29	R:R:S351	3.1	No	No	0	8	9
21	R:R:F352	R:R:I29	3.77	Yes	No	0	6	8
22	R:R:F62	R:R:M30	4.98	Yes	No	4	8	6
23	R:R:M30	R:R:V66	7.61	No	No	4	6	5
24	R:R:A58	R:R:N33	3.13	No	No	0	9	9
25	R:R:D61	R:R:N33	6.73	Yes	No	0	9	9
26	R:R:N33	R:R:P355	13.03	No	No	0	9	9
27	R:R:A58	R:R:V36	3.39	No	No	0	9	9
28	R:R:P359	R:R:V36	7.07	No	No	0	8	9
29	R:R:I37	R:R:L55	4.28	No	No	0	8	7
30	R:R:I372	R:R:L38	4.28	Yes	No	0	6	4
31	R:R:A39	R:R:F369	4.16	No	No	0	8	8
32	R:R:F40	R:R:R47	20.31	No	No	5	8	8
33	R:R:F40	R:R:Y52	7.22	No	No	5	8	6
34	R:R:F40	R:R:L55	17.05	No	No	0	8	7
35	R:R:I372	R:R:V42	7.68	Yes	No	0	6	6
36	R:R:D43	R:R:N45	4.04	No	No	0	7	6
37	R:R:D43	R:R:L46	12.21	No	No	0	7	9
38	R:R:A368	R:R:D43	4.63	No	No	0	8	7
39	R:R:K44	R:R:R47	3.71	No	No	0	7	8
40	R:R:L46	R:R:S51	4.5	No	No	2	9	9
41	R:R:F365	R:R:L46	12.18	Yes	No	2	8	9
42	R:R:R47	R:R:Y52	9.26	No	No	5	8	6
43	R:R:H48	R:R:R364	22.57	No	No	0	7	7
44	R:R:F53	R:R:R49	4.28	Yes	Yes	3	8	7
45	R:R:D111	R:R:R49	8.34	Yes	Yes	3	9	7
46	R:R:R49	R:R:Y122	8.23	Yes	Yes	3	7	8
47	R:R:Q125	R:R:R49	4.67	No	Yes	3	5	7
48	R:R:R49	R:R:T127	14.23	Yes	Yes	3	7	8
49	R:R:D111	R:R:S50	4.42	Yes	No	0	9	8
50	R:R:F365	R:R:S51	3.96	Yes	No	2	8	9
51	R:R:I132	R:R:Y52	8.46	No	No	0	7	6
52	R:R:F53	R:R:L107	15.83	Yes	No	0	8	8
53	R:R:D111	R:R:F53	9.55	Yes	Yes	3	9	8
54	R:R:F53	R:R:L135	3.65	Yes	No	0	8	7
55	R:R:F54	R:R:I108	6.28	Yes	No	0	8	9
56	R:R:F54	R:R:Y358	4.13	Yes	Yes	2	8	9
57	R:R:F54	R:R:P359	4.33	Yes	No	0	8	8
58	R:R:F54	R:R:H362	5.66	Yes	No	2	8	9
59	R:R:F365	R:R:F54	8.57	Yes	Yes	2	8	8
60	R:R:I59	R:R:L55	5.71	No	No	0	6	7
61	R:R:N104	R:R:N56	13.62	No	Yes	2	8	9
62	R:R:M136	R:R:N56	14.02	No	Yes	0	8	9
63	R:R:N56	R:R:V139	4.43	Yes	No	2	9	8
64	R:R:N56	R:R:W140	10.17	Yes	Yes	2	9	9
65	R:R:D61	R:R:L57	5.43	Yes	Yes	2	9	9
66	R:R:L57	R:R:N104	9.61	Yes	No	2	9	8
67	R:R:I105	R:R:L57	5.71	No	Yes	2	9	9
68	R:R:I108	R:R:L57	4.28	No	Yes	0	9	9
69	R:R:L57	R:R:N354	5.49	Yes	No	2	9	9
70	R:R:L57	R:R:Y358	3.52	Yes	Yes	2	9	9
71	R:R:D61	R:R:S60	4.42	Yes	Yes	2	9	9
72	R:R:A100	R:R:S60	3.42	No	Yes	2	8	9
73	R:R:S101	R:R:S60	4.89	No	Yes	2	9	9
74	R:R:S60	R:R:W140	3.71	Yes	Yes	2	9	9
75	R:R:D61	R:R:S101	10.31	Yes	No	2	9	9
76	R:R:D61	R:R:S351	8.83	Yes	No	0	9	9
77	R:R:D61	R:R:N354	8.08	Yes	No	2	9	9
78	R:R:F62	R:R:F63	9.65	Yes	No	0	8	6
79	R:R:F62	R:R:V66	7.87	Yes	No	4	8	5
80	R:R:F63	R:R:I67	6.28	No	No	0	6	6
81	R:R:F63	R:R:L97	3.65	No	No	0	6	6
82	R:R:V64	R:R:W348	3.68	No	Yes	0	8	8
83	R:R:S351	R:R:V64	9.7	No	No	0	9	8
84	R:R:G65	R:R:I69	5.29	No	Yes	0	8	8
85	R:R:D94	R:R:S68	8.83	Yes	No	1	8	8
86	R:R:S68	R:R:W348	3.71	No	Yes	1	8	8
87	R:R:I69	R:R:P70	3.39	Yes	No	0	8	9
88	R:R:I69	R:R:W345	3.52	Yes	Yes	1	8	8
89	R:R:I69	R:R:W348	8.22	Yes	Yes	1	8	8
90	R:R:L71	R:R:W90	6.83	No	Yes	0	5	7
91	R:R:T76	R:R:Y72	18.73	No	Yes	0	5	7
92	R:R:W90	R:R:Y72	5.79	Yes	Yes	0	7	7
93	R:R:F344	R:R:Y72	9.28	Yes	Yes	1	6	7
94	R:R:W345	R:R:Y72	5.79	Yes	Yes	1	8	7
95	R:R:W348	R:R:Y72	9.65	Yes	Yes	1	8	7
96	R:R:I73	R:R:P74	3.39	No	No	0	6	5
97	R:R:P74	R:R:W80	5.4	No	No	0	5	9
98	R:R:F82	R:R:H75	27.15	Yes	No	0	6	6
99	R:R:F82	R:R:W80	8.02	Yes	No	0	6	9
100	R:R:C87	R:R:F82	4.19	No	Yes	1	9	6
101	R:R:F82	R:R:W90	5.01	Yes	Yes	0	6	7
102	R:R:C164	R:R:F82	4.19	No	Yes	1	9	6
103	R:R:E155	R:R:K84	8.1	No	No	0	6	3
104	R:R:C87	R:R:L91	3.17	No	Yes	1	9	6
105	R:R:C164	R:R:C87	7.28	No	No	1	9	9
106	R:R:E155	R:R:V88	5.7	No	No	0	6	7
107	R:R:F89	R:R:T93	5.19	No	No	0	4	5
108	R:R:L91	R:R:W90	3.42	Yes	Yes	0	6	7
109	R:R:C164	R:R:L91	4.76	No	Yes	1	9	6
110	R:R:L91	R:R:P166	3.28	Yes	Yes	1	6	7
111	R:R:C98	R:R:D94	3.11	No	Yes	1	8	8
112	R:R:D94	R:R:W348	11.17	Yes	Yes	1	8	8
113	R:R:N147	R:R:Y95	12.79	Yes	Yes	0	8	8
114	R:R:I151	R:R:Y95	7.25	No	Yes	0	7	8
115	R:R:P166	R:R:Y95	11.13	Yes	Yes	0	7	8
116	R:R:L96	R:R:W140	5.69	No	Yes	0	6	9
117	R:R:T99	R:R:Y103	4.99	Yes	No	0	8	7
118	R:R:A143	R:R:T99	3.36	No	Yes	0	8	8
119	R:R:N147	R:R:T99	5.85	Yes	Yes	1	8	8
120	R:R:E182	R:R:T99	5.64	Yes	Yes	1	8	8
121	R:R:A100	R:R:W140	6.48	No	Yes	2	8	9
122	R:R:P186	R:R:V102	3.53	No	No	0	9	8
123	R:R:F312	R:R:V102	9.18	No	No	1	9	8
124	R:R:V102	R:R:W316	8.58	No	Yes	1	8	9
125	R:R:V146	R:R:Y103	6.31	No	No	0	7	7
126	R:R:N104	R:R:V139	7.39	No	No	2	8	8
127	R:R:I105	R:R:Y358	12.09	No	Yes	2	9	9
128	R:R:P186	R:R:V106	3.53	No	No	0	9	7
129	R:R:I108	R:R:R112	3.76	No	No	0	9	9
130	R:R:S109	R:R:V190	3.23	No	No	0	9	9
131	R:R:L114	R:R:Y110	14.07	No	No	0	5	6
132	R:R:F193	R:R:Y110	9.28	Yes	No	0	7	6
133	R:R:D111	R:R:Y122	11.49	Yes	Yes	3	9	8
134	R:R:R112	R:R:Y358	8.23	No	Yes	0	9	9
135	R:R:L114	R:R:Y113	3.52	No	Yes	0	5	9
136	R:R:S117	R:R:Y113	11.45	No	Yes	0	7	9
137	R:R:F193	R:R:Y113	11.35	Yes	Yes	0	7	9
138	R:R:N196	R:R:Y113	6.98	No	Yes	0	6	9
139	R:R:S115	R:R:V116	3.23	No	No	0	8	8
140	R:R:S115	R:R:Y122	7.63	No	Yes	0	8	8
141	R:R:S200	R:R:V116	9.7	No	No	0	6	8
142	R:R:N118	R:R:S121	7.45	No	No	0	6	5
143	R:R:Q125	R:R:Y122	3.38	No	Yes	3	5	8
144	R:R:Q125	R:R:T127	5.67	No	Yes	3	5	8
145	R:R:I132	R:R:T127	6.08	No	Yes	0	7	8
146	R:R:F144	R:R:G148	7.53	No	No	6	5	5
147	R:R:F144	R:R:P149	5.78	No	No	6	5	8
148	R:R:N147	R:R:V146	7.39	Yes	No	0	8	7
149	R:R:N147	R:R:T178	4.39	Yes	No	0	8	8
150	R:R:E182	R:R:N147	7.89	Yes	Yes	1	8	8
151	R:R:G148	R:R:P149	4.06	No	No	6	5	8
152	R:R:F168	R:R:M150	6.22	Yes	No	1	6	7
153	R:R:I174	R:R:M150	5.83	Yes	No	1	8	7
154	R:R:S154	R:R:W157	8.65	No	No	0	8	6
155	R:R:G167	R:R:S154	3.71	No	No	0	6	8
156	R:R:F168	R:R:S154	7.93	Yes	No	0	6	8
157	R:R:K158	R:R:S162	6.12	No	No	0	6	3
158	R:R:G167	R:R:K158	3.49	No	No	0	6	6
159	R:R:D159	R:R:E160	5.2	No	No	0	4	3
160	R:R:E165	R:R:F169	9.33	Yes	Yes	0	4	6
161	R:R:E165	R:R:T333	5.64	Yes	No	0	4	6
162	R:R:E165	R:R:K336	5.4	Yes	No	0	4	4
163	R:R:F168	R:R:P166	10.11	Yes	Yes	1	6	7
164	R:R:F169	R:R:P166	14.45	Yes	Yes	1	6	7
165	R:R:F168	R:R:F169	3.22	Yes	Yes	1	6	6
166	R:R:F168	R:R:I174	6.28	Yes	Yes	1	6	8
167	R:R:F168	R:R:L175	3.65	Yes	Yes	1	6	7
168	R:R:F169	R:R:L175	7.31	Yes	Yes	1	6	7
169	R:R:E171	R:R:S170	8.62	No	No	0	6	3
170	R:R:E171	R:R:Y173	11.22	No	No	1	6	4
171	R:R:E171	R:R:I174	6.83	No	Yes	1	6	8
172	R:R:F328	R:R:W172	12.03	No	No	0	5	4
173	R:R:I174	R:R:Y173	10.88	Yes	No	1	8	4
174	R:R:L175	R:R:T323	4.42	Yes	No	1	7	7
175	R:R:S179	R:R:S320	4.89	No	No	0	8	8
176	R:R:I324	R:R:S179	3.1	No	No	0	6	8
177	R:R:F180	R:R:V184	7.87	No	No	0	4	7
178	R:R:F180	R:R:I185	8.79	No	No	0	4	6
179	R:R:E182	R:R:W316	9.81	Yes	Yes	1	8	9
180	R:R:F183	R:R:V187	3.93	Yes	No	0	9	6
181	R:R:F183	R:R:W316	6.01	Yes	Yes	0	9	9
182	R:R:A317	R:R:F183	4.16	No	Yes	0	7	9
183	R:R:F183	R:R:S320	6.61	Yes	No	0	9	8
184	R:R:I185	R:R:P186	3.39	No	No	0	6	9
185	R:R:F312	R:R:V187	5.24	No	No	0	9	6
186	R:R:F193	R:R:L189	3.65	Yes	No	0	7	7
187	R:R:N194	R:R:V190	4.43	No	No	0	9	9
188	R:R:A191	R:R:L309	3.15	No	No	0	5	8
189	R:R:F193	R:R:Y192	4.13	Yes	No	0	7	5
190	R:R:N196	R:R:Y192	16.28	No	No	0	6	5
191	R:R:L305	R:R:N194	9.61	No	No	0	8	9
192	R:R:M195	R:R:W199	10.47	No	No	0	3	4
193	R:R:N196	R:R:W199	4.52	No	No	0	6	4
194	R:R:I197	R:R:L305	4.28	No	No	0	9	8
195	R:R:W202	R:R:Y198	6.75	No	Yes	0	6	7
196	R:R:A302	R:R:Y198	4	No	Yes	0	7	7
197	R:R:L201	R:R:W202	9.11	No	No	0	8	6
198	R:R:L201	R:R:L301	4.15	No	No	0	8	8
199	R:R:E291	R:R:E294	3.81	No	No	0	5	5
200	R:R:E294	R:R:R297	5.82	No	No	0	5	7
201	R:R:L301	R:R:L305	6.92	No	No	0	8	8
202	R:R:L308	R:R:L357	5.54	No	No	0	8	8
203	R:R:L308	R:R:Y358	11.72	No	Yes	0	8	9
204	R:R:L357	R:R:V311	4.47	No	No	0	8	6
205	R:R:F312	R:R:W316	7.02	No	Yes	1	9	9
206	R:R:C315	R:R:N350	4.72	No	No	0	8	9
207	R:R:Q347	R:R:W316	27.38	No	Yes	1	8	9
208	R:R:L346	R:R:P318	3.28	No	No	0	8	9
209	R:R:T323	R:R:Y319	8.74	No	Yes	1	7	7
210	R:R:Y319	R:R:Y340	10.92	Yes	Yes	1	7	5
211	R:R:F344	R:R:Y319	9.28	Yes	Yes	1	6	7
212	R:R:Q347	R:R:Y319	6.76	No	Yes	1	8	7
213	R:R:F322	R:R:L326	6.09	No	No	0	6	5
214	R:R:F322	R:R:Y340	10.32	No	Yes	0	6	5
215	R:R:T323	R:R:Y340	3.75	No	Yes	1	7	5
216	R:R:A332	R:R:S327	3.42	No	No	0	1	6
217	R:R:F328	R:R:Y329	7.22	No	No	0	5	5
218	R:R:G334	R:R:P335	4.06	No	No	0	1	4
219	R:R:K336	R:R:Y340	16.72	No	Yes	0	4	5
220	R:R:R341	R:R:V338	6.54	No	No	0	6	1
221	R:R:R341	R:R:W345	4	No	Yes	0	6	8
222	R:R:F344	R:R:W348	10.02	Yes	Yes	1	6	8
223	R:R:W345	R:R:W348	9.37	Yes	Yes	1	8	8
224	R:R:N350	R:R:N354	12.26	No	No	0	9	9
225	R:R:H362	R:R:R364	14.67	No	No	0	9	7
226	R:R:F365	R:R:H362	4.53	Yes	No	2	8	9
227	R:R:F365	R:R:F369	3.22	Yes	No	0	8	8
228	R:R:F373	R:R:I372	3.77	No	Yes	0	7	6
229	R:R:I197	R:R:V116	3.07	No	No	0	9	8
230	R:R:I342	R:R:V338	3.07	No	No	0	5	1
231	R:R:I151	R:R:T92	3.04	No	No	0	7	6
232	R:R:K131	R:R:T127	3	No	Yes	0	7	8
233	R:R:L175	R:R:S327	3	Yes	No	0	7	6
234	R:R:L326	R:R:S331	3	No	No	0	5	3
235	R:R:L12	R:R:V16	2.98	No	No	0	3	5
236	R:R:L97	R:R:V64	2.98	No	No	0	6	8
237	R:R:L189	R:R:V106	2.98	No	No	0	7	7
238	R:R:L107	R:R:V139	2.98	No	No	0	8	8
239	R:R:L309	R:R:V190	2.98	No	No	0	8	9
240	R:R:L18	R:R:T14	2.95	No	No	0	5	5
241	R:R:L97	R:R:T93	2.95	No	No	0	6	5
242	R:R:W172	R:R:Y173	2.89	No	No	0	4	4
243	R:R:L18	R:R:L77	2.77	No	No	0	5	6
244	R:R:A19	R:R:F78	2.77	No	No	0	5	5
245	R:R:A28	R:R:F352	2.77	No	Yes	0	4	6
246	R:R:A34	R:R:F62	2.77	No	Yes	0	4	8
247	R:R:L356	R:R:L360	2.77	No	No	0	6	6
248	R:R:K363	R:R:Q366	2.71	No	No	0	5	9
249	R:R:A298	R:R:Y198	2.67	No	Yes	0	8	7
250	R:R:A343	R:R:Y319	2.67	No	Yes	0	5	7
251	R:R:F349	R:R:V25	2.62	No	No	0	4	7
252	R:R:F352	R:R:V353	2.62	Yes	No	0	6	7
253	R:R:F144	R:R:T92	2.59	No	No	0	5	6
254	R:R:A176	R:R:W172	2.59	No	No	0	6	4
255	R:R:E163	R:R:E165	2.54	No	Yes	0	4	4
256	R:R:V325	R:R:Y329	2.52	No	No	0	6	5
257	R:R:F82	R:R:I86	2.51	Yes	No	0	6	5
258	R:R:S156	R:R:W157	2.47	No	No	0	5	6
259	R:R:V25	R:R:W345	2.45	No	Yes	0	7	8
260	R:R:F20	R:R:L24	2.44	No	No	0	4	5
261	R:R:F373	R:R:L35	2.44	No	No	0	7	8
262	R:R:F78	R:R:L77	2.44	No	No	0	5	6
263	R:R:F180	R:R:L181	2.44	No	No	0	4	5
264	R:R:F352	R:R:L356	2.44	Yes	No	0	6	6
265	R:R:F369	R:R:L360	2.44	No	No	0	8	6
266	R:R:L296	R:R:R300	2.43	No	No	0	4	8
267	R:R:I342	R:R:W339	2.35	No	No	0	5	5
268	R:R:L142	R:R:Y103	2.34	No	No	0	5	7
269	R:R:R297	R:R:R300	2.13	No	No	0	7	8
270	R:R:A317	R:R:P318	1.87	No	No	0	7	9
271	R:R:A343	R:R:P318	1.87	No	No	0	5	9
272	R:R:G334	R:R:T333	1.82	No	No	0	1	6
273	R:R:G83	R:R:I86	1.76	No	No	0	7	5
274	R:R:G32	R:R:L31	1.71	No	No	0	8	4
275	R:R:G310	R:R:L309	1.71	No	No	0	6	8
276	R:R:L145	R:R:P149	1.64	No	No	0	4	8
277	R:R:A39	R:R:I372	1.62	No	Yes	0	8	6
278	R:R:V129	R:R:V133	1.6	No	No	0	4	3
279	R:R:V133	R:R:V137	1.6	No	No	0	3	4
280	R:R:V137	R:R:V141	1.6	No	No	0	4	4
281	R:R:T92	R:R:V88	1.59	No	No	0	6	7
282	R:R:T124	R:R:V120	1.59	No	No	0	5	7
283	R:R:G128	R:R:H126	1.59	No	No	0	4	7
284	R:R:T14	R:R:T17	1.57	No	No	0	5	3
285	R:R:I188	R:R:V184	1.54	No	No	0	4	7
286	R:R:I307	R:R:V311	1.54	No	No	0	7	6
287	R:R:L152	R:R:V88	1.49	No	No	0	5	7
288	R:R:L145	R:R:V141	1.49	No	No	0	4	4
289	R:R:N118	R:R:V120	1.48	No	No	0	6	7
290	R:R:I307	R:R:K303	1.45	No	No	0	7	7
291	R:R:K363	R:R:K367	1.44	No	No	0	5	5
292	R:R:I177	R:R:L181	1.43	No	No	0	5	5
293	R:R:F322	R:R:S337	1.32	No	No	0	6	2
294	R:R:R297	R:R:V293	1.31	No	No	0	7	5
295	R:R:R123	R:R:T124	1.29	No	No	0	5	5
296	R:R:L12	R:R:R15	1.21	No	No	0	3	3
297	R:R:R299	R:R:Y198	1.03	No	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.72	9	1	0
2	R:R:R49	7.95	5	3	7
3	R:R:F53	8.3275	4	3	8
4	R:R:F54	5.794	5	2	8
5	R:R:N56	10.56	4	2	9
6	R:R:L57	5.67333	6	2	9
7	R:R:S60	4.11	4	2	9
8	R:R:D61	7.3	6	2	9
9	R:R:F62	6.3175	4	4	8
10	R:R:I69	5.058	5	1	8
11	R:R:Y72	9.848	5	1	7
12	R:R:F82	8.51167	6	1	6
13	R:R:W90	5.2625	4	0	7
14	R:R:L91	3.6575	4	1	6
15	R:R:D94	7.31	4	1	8
16	R:R:Y95	11.6	4	0	8
17	R:R:T99	4.96	4	1	8
18	R:R:D111	8.45	4	3	9
19	R:R:Y113	8.325	4	0	9
20	R:R:Y122	7.6825	4	3	8
21	R:R:T127	7.245	4	3	8
22	R:R:W140	6.5125	4	2	9
23	R:R:N147	7.662	5	1	8
24	R:R:E165	5.7275	4	0	4
25	R:R:P166	9.7425	4	1	7
26	R:R:F168	6.235	6	1	6
27	R:R:F169	8.5775	4	1	6
28	R:R:I174	7.455	4	1	8
29	R:R:L175	4.595	4	1	7
30	R:R:E182	7.3325	4	1	8
31	R:R:F183	5.1775	4	0	9
32	R:R:F193	7.1025	4	0	7
33	R:R:Y198	3.6125	4	0	7
34	R:R:W316	10.765	6	1	9
35	R:R:Y319	7.16833	6	1	7
36	R:R:Y340	10.4275	4	1	5
37	R:R:F344	10.7575	4	1	6
38	R:R:W345	5.93333	6	1	8
39	R:R:W348	8.02375	8	1	8
40	R:R:F352	2.9	4	0	6
41	R:R:Y358	7.938	5	2	9
42	R:R:F365	6.492	5	2	8
43	R:R:I372	4.3375	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W348	85.0044	8.37	Yes	Yes	1	0	8
2	R:R:W345	R:R:W348	23.7402	9.37	Yes	Yes	1	8	8
3	R:R:M22	R:R:W345	21.2371	10.47	No	Yes	0	7	8
4	R:R:L77	R:R:M22	16.0062	7.07	No	No	0	6	7
5	R:R:I69	R:R:W348	12.8059	8.22	Yes	Yes	1	8	8
6	R:R:G65	R:R:I69	13.9662	5.29	No	Yes	0	8	8
7	R:R:V64	R:R:W348	100	3.68	No	Yes	0	8	8
8	R:R:S351	R:R:V64	97.9413	9.7	No	No	0	9	8
9	R:R:I29	R:R:S351	13.2083	3.1	No	No	0	8	9
10	R:R:G65	R:R:I29	13.6761	3.53	No	No	0	8	8
11	R:R:F352	R:R:I29	21.2464	3.77	Yes	No	0	6	8
12	R:R:L97	R:R:V64	12.2491	2.98	No	No	0	6	8
13	R:R:D61	R:R:S351	92.1724	8.83	Yes	No	0	9	9
14	R:R:D61	R:R:L57	81.6685	5.43	Yes	Yes	2	9	9
15	R:R:I108	R:R:L57	18.0321	4.28	No	Yes	0	9	9
16	R:R:F54	R:R:I108	15.8705	6.28	Yes	No	0	8	9
17	R:R:L57	R:R:Y358	23.9789	3.52	Yes	Yes	2	9	9
18	R:R:F54	R:R:Y358	16.5817	4.13	Yes	Yes	2	8	9
19	R:R:L57	R:R:N104	67.4636	9.61	Yes	No	2	9	8
20	R:R:N104	R:R:V139	63.8376	7.39	No	No	2	8	8
21	R:R:L107	R:R:V139	64.7406	2.98	No	No	0	8	8
22	R:R:F53	R:R:L107	63.8001	15.83	Yes	No	0	8	8
23	R:R:F53	R:R:R49	36.8502	4.28	Yes	Yes	3	8	7
24	R:R:R49	R:R:T127	12.8714	14.23	Yes	Yes	3	7	8
25	R:R:I132	R:R:T127	11.1496	6.08	No	Yes	0	7	8
26	R:R:F352	R:R:L356	15.6178	2.44	Yes	No	0	6	6
27	R:R:L356	R:R:L360	13.8212	2.77	No	No	0	6	6
28	R:R:F369	R:R:L360	12.9088	2.44	No	No	0	8	6
29	R:R:A39	R:R:F369	14.3967	4.16	No	No	0	8	8
30	R:R:A39	R:R:I372	12.0198	1.62	No	Yes	0	8	6
31	R:R:F365	R:R:F54	20.1329	8.57	Yes	Yes	2	8	8
32	R:R:F365	R:R:L46	10.3261	12.18	Yes	No	2	8	9
33	R:R:D111	R:R:F53	24.9614	9.55	Yes	Yes	3	9	8
34	R:R:R49	R:R:Y122	23.5531	8.23	Yes	Yes	3	7	8
35	R:R:D111	R:R:Y122	22.7904	11.49	Yes	Yes	3	9	8
36	R:R:W90	R:R:Y72	16.1933	5.79	Yes	Yes	0	7	7
37	R:R:W348	R:R:Y72	11.5754	9.65	Yes	Yes	1	8	7
38	R:R:F82	R:R:W90	10.3869	5.01	Yes	Yes	0	6	7
39	L:L:?1	R:R:Y95	42.5163	15.23	Yes	Yes	0	0	8
40	R:R:P166	R:R:Y95	30.1315	11.13	Yes	Yes	0	7	8
41	R:R:I151	R:R:Y95	18.9257	7.25	No	Yes	0	7	8
42	R:R:I151	R:R:T92	17.756	3.04	No	No	0	7	6
43	L:L:?1	R:R:W316	37.7766	5.79	Yes	Yes	1	0	9
44	R:R:V102	R:R:W316	30.866	8.58	No	Yes	1	8	9
45	R:R:P186	R:R:V102	29.8274	3.53	No	No	0	9	8
46	R:R:P186	R:R:V106	20.7879	3.53	No	No	0	9	7
47	R:R:S115	R:R:Y122	45.0147	7.63	No	Yes	0	8	8
48	R:R:S115	R:R:V116	42.563	3.23	No	No	0	8	8
49	R:R:I197	R:R:V116	37.6316	3.07	No	No	0	9	8
50	R:R:I197	R:R:L305	35.1425	4.28	No	No	0	9	8
51	R:R:L305	R:R:N194	15.5196	9.61	No	No	0	8	9
52	R:R:N194	R:R:V190	12.9556	4.43	No	No	0	9	9
53	R:R:L189	R:R:V106	19.4591	2.98	No	No	0	7	7
54	R:R:F193	R:R:L189	18.121	3.65	Yes	No	0	7	7
55	R:R:F144	R:R:T92	11.1122	2.59	No	No	0	5	6
56	R:R:F168	R:R:P166	23.6092	10.11	Yes	Yes	1	6	7
57	R:R:F168	R:R:I174	13.3439	6.28	Yes	Yes	1	6	8
58	L:L:?1	R:R:Y319	19.5246	4.64	Yes	Yes	1	0	7
59	R:R:Y319	R:R:Y340	23.5156	10.92	Yes	Yes	1	7	5
60	R:R:K336	R:R:Y340	12.5158	16.72	No	Yes	0	4	5
61	R:R:E165	R:R:K336	10.5601	5.4	Yes	No	0	4	4
62	R:R:E165	R:R:T333	10.5647	5.64	Yes	No	0	4	6
63	R:R:L301	R:R:L305	17.6999	6.92	No	No	0	8	8
64	R:R:L201	R:R:L301	15.3137	4.15	No	No	0	8	8
65	R:R:L201	R:R:W202	12.7591	9.11	No	No	0	8	6
66	R:R:W202	R:R:Y198	10.1857	6.75	No	Yes	0	6	7
67	R:R:F344	R:R:W348	15.95	10.02	Yes	Yes	1	6	8
68	R:R:F344	R:R:Y319	18.0227	9.28	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D94	6.13	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y95	15.23	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:C98	3.59	1	Yes	No	0	8	0	1
L:L:?1	R:R:E182	5.99	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W316	5.79	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y319	4.64	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F344	14.45	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q347	14.29	1	Yes	No	0	8	0	1
L:L:?1	R:R:W348	8.37	1	Yes	Yes	0	8	0	1
R:R:V64	R:R:W348	3.68	0	No	Yes	8	8	2	1
R:R:D94	R:R:S68	8.83	1	Yes	No	8	8	1	2
R:R:S68	R:R:W348	3.71	1	No	Yes	8	8	2	1
R:R:I69	R:R:W345	3.52	1	Yes	Yes	8	8	2	2
R:R:I69	R:R:W348	8.22	1	Yes	Yes	8	8	2	1
R:R:F344	R:R:Y72	9.28	1	Yes	Yes	6	7	1	2
R:R:W345	R:R:Y72	5.79	1	Yes	Yes	8	7	2	2
R:R:W348	R:R:Y72	9.65	1	Yes	Yes	8	7	1	2
R:R:C98	R:R:D94	3.11	1	No	Yes	8	8	1	1
R:R:D94	R:R:W348	11.17	1	Yes	Yes	8	8	1	1
R:R:N147	R:R:Y95	12.79	1	Yes	Yes	8	8	2	1
R:R:I151	R:R:Y95	7.25	0	No	Yes	7	8	2	1
R:R:P166	R:R:Y95	11.13	1	Yes	Yes	7	8	2	1
R:R:N147	R:R:T99	5.85	1	Yes	Yes	8	8	2	2
R:R:E182	R:R:T99	5.64	1	Yes	Yes	8	8	1	2
R:R:F312	R:R:V102	9.18	1	No	No	9	8	2	2
R:R:V102	R:R:W316	8.58	1	No	Yes	8	9	2	1
R:R:E182	R:R:N147	7.89	1	Yes	Yes	8	8	1	2
R:R:E182	R:R:W316	9.81	1	Yes	Yes	8	9	1	1
R:R:F183	R:R:W316	6.01	0	Yes	Yes	9	9	2	1
R:R:F312	R:R:W316	7.02	1	No	Yes	9	9	2	1
R:R:Q347	R:R:W316	27.38	1	No	Yes	8	9	1	1
R:R:T323	R:R:Y319	8.74	1	No	Yes	7	7	2	1
R:R:Y319	R:R:Y340	10.92	1	Yes	Yes	7	5	1	2
R:R:F344	R:R:Y319	9.28	1	Yes	Yes	6	7	1	1
R:R:Q347	R:R:Y319	6.76	1	No	Yes	8	7	1	1
R:R:T323	R:R:Y340	3.75	1	No	Yes	7	5	2	2
R:R:F344	R:R:W348	10.02	1	Yes	Yes	6	8	1	1
R:R:W345	R:R:W348	9.37	1	Yes	Yes	8	8	2	1
R:R:A343	R:R:Y319	2.67	0	No	Yes	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YNA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	254
Number of Links	297
Number of Hubs	43
Number of Links mediated by Hubs	153
Number of Communities	6
Number of Nodes involved in Communities	63
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	45719
Length Of Smallest Path	3
Average Path Length	12.9447
Length of Longest Path	31
Minimum Path Strength	1.44
Average Path Strength	6.8435
Maximum Path Strength	18.68
Minimum Path Correlation	0.7
Average Path Correlation	0.920638
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	49.731
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.1805
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • MAPK cascade • regulation of cell communication • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>8YNA_nogp_Chain_R S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D K N L R H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N A V S Y R T Q H T G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K D E G S E C E P G F F S E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W E H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S S A T G P K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F Q K A F L K I F C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ	2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	10.1038/s41589-024-01620-6
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	10.1038/s41467-024-46840-5
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	10.1038/s41467-024-46840-5
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	10.1038/s41467-024-46840-5
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	10.1038/s41467-023-42260-z
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	10.1038/s41467-023-42260-z
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	10.1038/s41422-023-00835-x
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	10.1038/s41467-023-41654-3
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WH4 (Multimeric)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-		3.4	2020-09-23	10.1016/j.cell.2020.08.024

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