psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F78	R:R:R15	4.28	No	No	0	5	3
2	R:R:F20	R:R:L21	4.87	No	No	0	4	4
3	R:R:I73	R:R:M22	5.83	Yes	No	0	6	7
4	R:R:M22	R:R:W345	11.63	No	No	0	7	8
5	R:R:I29	R:R:L25	4.28	No	No	0	8	7
6	R:R:F352	R:R:L25	3.65	No	No	0	6	7
7	R:R:A26	R:R:I69	4.87	No	No	0	7	8
8	R:R:F27	R:R:L31	13.4	No	No	0	5	4
9	R:R:A28	R:R:F352	4.16	No	No	0	4	6
10	R:R:G65	R:R:I29	3.53	No	No	0	8	8
11	R:R:M30	R:R:V66	4.56	No	No	0	6	5
12	R:R:D61	R:R:N33	6.73	No	No	0	9	9
13	R:R:F62	R:R:N33	4.83	No	No	0	8	9
14	R:R:N33	R:R:P355	4.89	No	No	0	9	9
15	R:R:F369	R:R:V35	3.93	No	No	0	8	8
16	R:R:A58	R:R:V36	3.39	No	No	0	9	9
17	R:R:A58	R:R:I37	3.25	No	No	0	9	8
18	R:R:I372	R:R:L38	5.71	No	No	0	6	4
19	R:R:F40	R:R:R47	6.41	No	No	0	8	8
20	R:R:F40	R:R:L55	10.96	No	No	0	8	7
21	R:R:F365	R:R:F40	3.22	Yes	No	0	8	8
22	R:R:D43	R:R:V42	4.38	Yes	No	0	7	6
23	R:R:I372	R:R:V42	6.14	No	No	0	6	6
24	R:R:D43	R:R:N45	6.73	Yes	No	0	7	6
25	R:R:D43	R:R:K371	6.91	Yes	No	0	7	5
26	R:R:K44	R:R:R47	4.95	No	No	0	7	8
27	R:R:L46	R:R:N45	6.87	No	No	0	9	6
28	R:R:L46	R:R:N51	5.49	No	Yes	2	9	9
29	R:R:F365	R:R:L46	3.65	Yes	No	2	8	9
30	R:R:R47	R:R:Y52	5.14	No	No	0	8	6
31	R:R:R49	R:R:Y122	10.29	No	No	0	7	8
32	R:R:Q125	R:R:R49	7.01	No	No	0	5	7
33	R:R:R49	R:R:T127	10.35	No	No	0	7	8
34	R:R:D111	R:R:S50	4.42	No	No	0	9	8
35	R:R:H362	R:R:N51	3.83	Yes	Yes	2	9	9
36	R:R:F365	R:R:N51	8.46	Yes	Yes	2	8	9
37	R:R:I129	R:R:Y52	3.63	No	No	0	4	6
38	R:R:I132	R:R:Y52	9.67	No	No	0	7	6
39	R:R:F53	R:R:L107	10.96	No	No	0	8	8
40	R:R:F53	R:R:I108	5.02	No	No	0	8	9
41	R:R:D111	R:R:F53	3.58	No	No	0	9	8
42	R:R:F54	R:R:I108	6.28	Yes	No	0	8	9
43	R:R:F54	R:R:Y358	4.13	Yes	Yes	0	8	9
44	R:R:F54	R:R:P359	4.33	Yes	No	0	8	8
45	R:R:F54	R:R:H362	5.66	Yes	Yes	2	8	9
46	R:R:F365	R:R:F54	3.22	Yes	Yes	2	8	8
47	R:R:I59	R:R:L55	4.28	No	No	0	6	7
48	R:R:N104	R:R:N56	6.81	No	No	0	8	9
49	R:R:M136	R:R:N56	12.62	No	No	0	8	9
50	R:R:L57	R:R:N354	6.87	No	No	0	9	9
51	R:R:F63	R:R:I59	3.77	No	No	0	6	6
52	R:R:S60	R:R:W140	7.41	No	Yes	0	9	9
53	R:R:D61	R:R:S351	7.36	No	No	0	9	9
54	R:R:D61	R:R:N354	6.73	No	No	0	9	9
55	R:R:F62	R:R:F63	4.29	No	No	0	8	6
56	R:R:F62	R:R:V66	7.87	No	No	0	8	5
57	R:R:F63	R:R:L97	4.87	No	No	0	6	6
58	R:R:G65	R:R:V64	3.68	No	No	0	8	8
59	R:R:L97	R:R:V64	5.96	No	No	0	6	8
60	R:R:D94	R:R:S68	8.83	No	No	1	8	8
61	R:R:S68	R:R:W348	7.41	No	Yes	1	8	8
62	R:R:I69	R:R:P70	5.08	No	No	0	8	9
63	R:R:L71	R:R:W90	3.42	No	No	0	5	7
64	R:R:T76	R:R:Y72	7.49	No	Yes	0	5	7
65	R:R:W90	R:R:Y72	9.65	No	Yes	0	7	7
66	R:R:F344	R:R:Y72	11.35	Yes	Yes	1	6	7
67	R:R:W345	R:R:Y72	5.79	No	Yes	1	8	7
68	R:R:W348	R:R:Y72	6.75	Yes	Yes	1	8	7
69	R:R:I73	R:R:P74	3.39	Yes	No	0	6	5
70	R:R:D81	R:R:P74	8.05	No	No	0	3	5
71	R:R:D81	R:R:H75	8.82	No	No	0	3	6
72	R:R:D81	R:R:E79	5.2	No	No	0	3	3
73	R:R:E163	R:R:F82	9.33	No	No	0	4	6
74	R:R:C164	R:R:C87	7.28	No	No	0	9	9
75	R:R:E155	R:R:V88	5.7	No	No	0	6	7
76	R:R:F89	R:R:T93	3.89	No	No	0	4	5
77	R:R:L91	R:R:W90	5.69	No	No	0	6	7
78	R:R:L91	R:R:Y95	3.52	No	Yes	1	6	8
79	R:R:L91	R:R:P166	3.28	No	Yes	1	6	7
80	R:R:D94	R:R:W348	11.17	No	Yes	1	8	8
81	L:L:?1	R:R:D94	12.15	Yes	No	1	0	8
82	R:R:N147	R:R:Y95	9.3	No	Yes	1	8	8
83	R:R:I151	R:R:Y95	4.84	Yes	Yes	1	7	8
84	R:R:P166	R:R:Y95	6.95	Yes	Yes	1	7	8
85	L:L:?1	R:R:Y95	13.36	Yes	Yes	1	0	8
86	R:R:L96	R:R:W140	4.56	No	Yes	0	6	9
87	R:R:C98	R:R:W316	3.92	No	Yes	1	8	9
88	L:L:?1	R:R:C98	6.46	Yes	No	1	0	8
89	R:R:T99	R:R:Y103	7.49	No	Yes	0	8	7
90	R:R:A143	R:R:T99	3.36	No	No	0	8	8
91	R:R:A100	R:R:W140	7.78	No	Yes	0	8	9
92	R:R:V102	R:R:Y103	3.79	Yes	Yes	1	8	7
93	R:R:P186	R:R:V102	3.53	No	Yes	0	9	8
94	R:R:F312	R:R:V102	3.93	Yes	Yes	1	9	8
95	R:R:V102	R:R:W316	8.58	Yes	Yes	1	8	9
96	R:R:V146	R:R:Y103	6.31	No	Yes	1	7	7
97	R:R:E182	R:R:Y103	3.37	Yes	Yes	1	8	7
98	R:R:N104	R:R:V139	4.43	No	No	0	8	8
99	R:R:I105	R:R:Y358	12.09	No	Yes	0	9	9
100	R:R:I108	R:R:R112	3.76	No	No	0	9	9
101	R:R:S109	R:R:V190	6.46	No	No	0	9	9
102	R:R:F193	R:R:S109	5.28	Yes	No	0	7	9
103	R:R:Q114	R:R:Y110	15.78	No	No	0	5	6
104	R:R:F193	R:R:Y110	4.13	Yes	No	0	7	6
105	R:R:D111	R:R:Y122	11.49	No	No	0	9	8
106	R:R:R112	R:R:Y358	6.17	No	Yes	0	9	9
107	R:R:Y113	R:R:Y192	3.97	No	No	3	9	5
108	R:R:F193	R:R:Y113	7.22	Yes	No	3	7	9
109	R:R:Y113	R:R:Y196	10.92	No	No	0	9	6
110	R:R:S115	R:R:Y122	10.17	No	No	0	8	8
111	R:R:I197	R:R:V116	7.68	No	No	0	9	8
112	R:R:S200	R:R:V116	3.23	No	No	0	6	8
113	R:R:N118	R:R:S117	5.96	No	No	0	6	7
114	R:R:S117	R:R:Y196	6.36	No	No	0	7	6
115	R:R:N118	R:R:S121	4.47	No	No	0	6	5
116	R:R:Q125	R:R:S121	4.33	No	No	0	5	5
117	R:R:G128	R:R:T127	3.64	No	No	0	4	8
118	R:R:F144	R:R:P149	8.67	No	No	0	5	8
119	R:R:L181	R:R:V146	7.45	No	No	0	5	7
120	R:R:E182	R:R:V146	4.28	Yes	No	1	8	7
121	R:R:I151	R:R:N147	7.08	Yes	No	1	7	8
122	R:R:F168	R:R:N147	6.04	Yes	No	1	6	8
123	R:R:G148	R:R:P149	4.06	No	No	0	5	8
124	R:R:F168	R:R:M150	6.22	Yes	No	1	6	7
125	R:R:I174	R:R:M150	4.37	No	No	1	8	7
126	R:R:F168	R:R:I151	3.77	Yes	Yes	1	6	7
127	R:R:S154	R:R:W157	8.65	No	No	0	8	6
128	R:R:G167	R:R:S154	3.71	No	No	0	6	8
129	R:R:F168	R:R:S154	7.93	Yes	No	0	6	8
130	R:R:S156	R:R:W157	3.71	No	No	0	5	6
131	R:R:G167	R:R:K158	5.23	No	No	0	6	6
132	R:R:E160	R:R:G161	3.27	No	No	0	3	1
133	R:R:C164	R:R:E163	7.6	No	No	0	9	4
134	R:R:E165	R:R:F169	8.16	No	Yes	0	4	6
135	R:R:E165	R:R:K336	6.75	No	No	0	4	4
136	R:R:F168	R:R:P166	11.56	Yes	Yes	1	6	7
137	R:R:F169	R:R:P166	14.45	Yes	Yes	1	6	7
138	R:R:F168	R:R:F169	3.22	Yes	Yes	1	6	6
139	R:R:F168	R:R:I174	6.28	Yes	No	1	6	8
140	R:R:F168	R:R:L175	3.65	Yes	No	1	6	7
141	R:R:F169	R:R:L175	4.87	Yes	No	1	6	7
142	R:R:F169	R:R:T323	3.89	Yes	No	0	6	7
143	R:R:E171	R:R:S170	7.19	No	No	0	6	3
144	R:R:E171	R:R:Y173	19.08	No	No	0	6	4
145	R:R:W172	R:R:Y173	9.65	No	No	0	4	4
146	R:R:F328	R:R:W172	4.01	No	No	0	5	4
147	R:R:I174	R:R:Y173	6.04	No	No	0	8	4
148	R:R:E182	R:R:T178	7.06	Yes	No	0	8	8
149	R:R:S179	R:R:S320	4.89	No	No	0	8	8
150	R:R:I324	R:R:S179	4.64	No	No	0	6	8
151	R:R:F180	R:R:L184	6.09	No	No	0	4	7
152	R:R:F180	R:R:V185	3.93	No	No	0	4	6
153	L:L:?1	R:R:E182	5.39	Yes	Yes	1	0	8
154	R:R:A317	R:R:F183	4.16	No	No	0	7	9
155	R:R:P186	R:R:V185	3.53	No	No	0	9	6
156	R:R:F312	R:R:V187	5.24	Yes	No	0	9	6
157	R:R:F193	R:R:L189	3.65	Yes	No	0	7	7
158	R:R:F193	R:R:Y192	5.16	Yes	No	3	7	5
159	R:R:L305	R:R:N194	6.87	No	No	0	8	9
160	R:R:A302	R:R:Y198	5.34	No	No	0	7	7
161	R:R:L201	R:R:L301	4.15	No	No	0	8	8
162	R:R:E294	R:R:G205	4.91	No	No	0	5	5
163	R:R:H292	R:R:L293	14.14	No	No	0	5	5
164	R:R:L293	R:R:R297	4.86	No	No	0	5	7
165	R:R:L295	R:R:R299	8.5	No	No	0	4	6
166	R:R:L301	R:R:L305	5.54	No	No	0	8	8
167	R:R:I307	R:R:K303	4.36	No	No	0	7	7
168	R:R:L308	R:R:L357	5.54	No	No	0	8	8
169	R:R:L308	R:R:Y358	9.38	No	Yes	0	8	9
170	R:R:F312	R:R:W316	10.02	Yes	Yes	1	9	9
171	R:R:C315	R:R:N350	12.6	Yes	No	0	8	9
172	R:R:Q347	R:R:W316	13.14	No	Yes	1	8	9
173	R:R:N350	R:R:W316	7.91	No	Yes	0	9	9
174	L:L:?1	R:R:W316	5.56	Yes	Yes	1	0	9
175	R:R:T323	R:R:Y319	8.74	No	Yes	0	7	7
176	R:R:Y319	R:R:Y340	10.92	Yes	No	0	7	5
177	R:R:F344	R:R:Y319	6.19	Yes	Yes	1	6	7
178	R:R:Q347	R:R:Y319	9.02	No	Yes	1	8	7
179	L:L:?1	R:R:Y319	4.77	Yes	Yes	1	0	7
180	R:R:F322	R:R:L326	8.53	Yes	No	4	6	5
181	R:R:F322	R:R:R334	4.28	Yes	Yes	4	6	1
182	R:R:F322	R:R:Y340	8.25	Yes	No	0	6	5
183	R:R:L326	R:R:R334	4.86	No	Yes	4	5	1
184	R:R:P330	R:R:Y329	4.17	No	No	0	2	5
185	R:R:R334	R:R:Y329	7.2	Yes	No	0	1	5
186	R:R:P335	R:R:R334	4.32	No	Yes	0	4	1
187	R:R:R334	R:R:S337	6.59	Yes	No	0	1	2
188	R:R:K336	R:R:Y340	15.53	No	No	0	4	5
189	R:R:F344	R:R:W348	8.02	Yes	Yes	1	6	8
190	L:L:?1	R:R:F344	16.86	Yes	Yes	1	0	6
191	R:R:W345	R:R:W348	11.25	No	Yes	1	8	8
192	L:L:?1	R:R:Q347	11.92	Yes	No	1	0	8
193	L:L:?1	R:R:W348	12.05	Yes	Yes	1	0	8
194	R:R:N350	R:R:N354	5.45	No	No	0	9	9
195	R:R:F352	R:R:F356	6.43	No	No	0	6	6
196	R:R:H362	R:R:R364	6.77	Yes	No	0	9	7
197	R:R:F365	R:R:H362	4.53	Yes	Yes	2	8	9
198	R:R:F373	R:R:I372	3.77	No	No	0	7	6
199	R:R:A191	R:R:L309	3.15	No	No	0	5	8
200	R:R:A368	R:R:D43	3.09	No	Yes	0	8	7
201	R:R:I67	R:R:V66	3.07	No	No	0	6	5
202	R:R:I129	R:R:V133	3.07	No	No	0	4	3
203	R:R:I342	R:R:V338	3.07	No	No	0	5	1
204	R:R:M136	R:R:V133	3.04	No	No	0	8	3
205	R:R:K131	R:R:T127	3	No	No	0	7	8
206	R:R:L175	R:R:S327	3	No	No	0	7	6
207	R:R:L309	R:R:V190	2.98	No	No	0	8	9
208	R:R:N194	R:R:V190	2.96	No	No	0	9	9
209	R:R:L21	R:R:T17	2.95	No	No	0	4	3
210	R:R:L77	R:R:T76	2.95	No	No	0	6	5
211	R:R:I69	R:R:I73	2.94	No	Yes	0	8	6
212	R:R:I197	R:R:L305	2.85	No	No	0	9	8
213	R:R:W199	R:R:W202	2.81	No	No	0	4	6
214	R:R:A39	R:R:F369	2.77	No	No	0	8	8
215	R:R:K363	R:R:Q366	2.71	No	No	0	5	9
216	R:R:E85	R:R:K84	2.7	No	No	0	3	3
217	R:R:A343	R:R:Y319	2.67	No	Yes	0	5	7
218	R:R:F144	R:R:T92	2.59	No	No	0	5	6
219	R:R:R123	R:R:T124	2.59	No	No	0	5	5
220	R:R:S337	R:R:W339	2.47	No	No	0	2	5
221	R:R:F20	R:R:L24	2.44	No	No	0	4	5
222	R:R:F349	R:R:L25	2.44	No	No	0	4	7
223	R:R:M195	R:R:Y192	2.39	No	No	0	3	5
224	R:R:I342	R:R:W339	2.35	No	No	0	5	5
225	R:R:L301	R:R:Y198	2.34	No	No	0	8	7
226	R:R:L97	R:R:W140	2.28	No	Yes	0	6	9
227	R:R:F82	R:R:H75	2.26	No	No	0	6	6
228	R:R:F183	R:R:F312	2.14	No	Yes	0	9	9
229	R:R:F365	R:R:F369	2.14	Yes	No	0	8	8
230	R:R:F78	R:R:W80	2	No	No	0	5	9
231	R:R:F82	R:R:W80	2	No	No	0	6	9
232	R:R:A317	R:R:P318	1.87	No	No	0	7	9
233	R:R:P355	R:R:V36	1.77	No	No	0	9	9
234	R:R:P359	R:R:V36	1.77	No	No	0	8	9
235	R:R:P186	R:R:V106	1.77	No	No	0	9	7
236	R:R:G83	R:R:I86	1.76	No	No	0	7	5
237	R:R:G148	R:R:I151	1.76	No	Yes	0	5	7
238	R:R:G32	R:R:L31	1.71	No	No	0	8	4
239	R:R:G310	R:R:L309	1.71	No	No	0	6	8
240	R:R:C315	R:R:V311	1.71	Yes	No	0	8	6
241	R:R:C315	R:R:V314	1.71	Yes	No	0	8	4
242	R:R:E163	R:R:G83	1.64	No	No	0	4	7
243	R:R:C87	R:R:I86	1.64	No	No	0	9	5
244	R:R:L145	R:R:P149	1.64	No	No	0	4	8
245	R:R:S101	R:R:S60	1.63	No	No	0	9	9
246	R:R:V41	R:R:V42	1.6	No	No	0	3	6
247	R:R:V133	R:R:V137	1.6	No	No	0	3	4
248	R:R:V137	R:R:V141	1.6	No	No	0	4	4
249	R:R:V311	R:R:V353	1.6	No	No	0	6	7
250	R:R:T92	R:R:V88	1.59	No	No	0	6	7
251	R:R:G128	R:R:H126	1.59	No	No	0	4	7
252	R:R:C315	R:R:L346	1.59	Yes	No	0	8	8
253	R:R:C361	R:R:L360	1.59	No	No	0	7	6
254	R:R:A19	R:R:L77	1.58	No	No	0	5	6
255	R:R:A317	R:R:L321	1.58	No	No	0	7	6
256	R:R:I73	R:R:S23	1.55	Yes	No	0	6	5
257	R:R:I188	R:R:V187	1.54	No	No	0	4	6
258	R:R:I307	R:R:V311	1.54	No	No	0	7	6
259	R:R:K203	R:R:S200	1.53	No	No	0	6	6
260	R:R:K303	R:R:S304	1.53	No	No	0	7	8
261	R:R:I67	R:R:T93	1.52	No	No	0	6	5
262	R:R:G205	R:R:R204	1.5	No	No	0	5	8
263	R:R:L321	R:R:S320	1.5	No	No	0	6	8
264	R:R:L152	R:R:V88	1.49	No	No	0	5	7
265	R:R:E160	R:R:K84	1.35	No	No	0	3	3
266	R:R:A298	R:R:Y198	1.33	No	No	0	8	7
267	R:R:R204	R:R:S200	1.32	No	No	0	8	6
268	R:R:F322	R:R:V325	1.31	Yes	No	0	6	6
269	R:R:D159	R:R:E160	1.3	No	No	0	4	3
270	R:R:A298	R:R:W202	1.3	No	No	0	8	6
271	R:R:H48	R:R:N51	1.28	No	Yes	0	7	9
272	R:R:I16	R:R:R15	1.25	No	No	0	5	3
273	R:R:K336	R:R:R341	1.24	No	No	0	4	6
274	R:R:F356	R:R:L360	1.22	No	No	0	6	6
275	R:R:L142	R:R:Y103	1.17	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D43	5.2775	4	0	7
2	R:R:N51	4.765	4	2	9
3	R:R:F54	4.724	5	2	8
4	R:R:Y72	8.206	5	1	7
5	R:R:I73	3.4275	4	0	6
6	R:R:Y95	7.594	5	1	8
7	R:R:V102	4.9575	4	1	8
8	R:R:Y103	4.426	5	1	7
9	R:R:W140	5.5075	4	0	9
10	R:R:I151	4.3625	4	1	7
11	R:R:P166	9.06	4	1	7
12	R:R:F168	6.08375	8	1	6
13	R:R:F169	6.918	5	1	6
14	R:R:E182	5.025	4	1	8
15	R:R:F193	5.088	5	3	7
16	R:R:F312	5.3325	4	1	9
17	R:R:C315	4.4025	4	0	8
18	R:R:W316	8.18833	6	1	9
19	R:R:Y319	7.05167	6	1	7
20	R:R:F322	5.5925	4	4	6
21	R:R:R334	5.45	5	4	1
22	R:R:F344	10.605	4	1	6
23	R:R:W348	9.44167	6	1	8
24	R:R:Y358	7.9425	4	0	9
25	R:R:H362	5.1975	4	2	9
26	R:R:F365	4.20333	6	2	8
27	L:L:?1	9.83556	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F82	R:R:H75	14.3476	2.26	No	No	0	6	6
2	R:R:D81	R:R:H75	15.7596	8.82	No	No	0	3	6
3	R:R:D81	R:R:P74	18.5567	8.05	No	No	0	3	5
4	R:R:I73	R:R:P74	19.9419	3.39	Yes	No	0	6	5
5	R:R:I73	R:R:M22	26.7337	5.83	Yes	No	0	6	7
6	R:R:M22	R:R:W345	27.9223	11.63	No	No	0	7	8
7	R:R:W345	R:R:W348	24.6336	11.25	No	Yes	1	8	8
8	L:L:?1	R:R:W348	28.5389	12.05	Yes	Yes	1	0	8
9	L:L:?1	R:R:W316	82.7435	5.56	Yes	Yes	1	0	9
10	R:R:N350	R:R:W316	100	7.91	No	Yes	0	9	9
11	R:R:N350	R:R:N354	97.815	5.45	No	No	0	9	9
12	R:R:D61	R:R:N354	97.2163	6.73	No	No	0	9	9
13	R:R:D61	R:R:N33	96.5818	6.73	No	No	0	9	9
14	R:R:F62	R:R:N33	33.9053	4.83	No	No	0	8	9
15	R:R:F62	R:R:F63	28.5702	4.29	No	No	0	8	6
16	R:R:F63	R:R:L97	20.5139	4.87	No	No	0	6	6
17	R:R:L97	R:R:V64	13.0876	5.96	No	No	0	6	8
18	R:R:G65	R:R:V64	11.8186	3.68	No	No	0	8	8
19	R:R:G65	R:R:I29	10.5407	3.53	No	No	0	8	8
20	R:R:N33	R:R:P355	66.3092	4.89	No	No	0	9	9
21	R:R:F365	R:R:F54	25.0268	3.22	Yes	Yes	2	8	8
22	R:R:F54	R:R:P359	63.3959	4.33	Yes	No	0	8	8
23	R:R:P359	R:R:V36	63.9768	1.77	No	No	0	8	9
24	R:R:P355	R:R:V36	65.7462	1.77	No	No	0	9	9
25	R:R:F365	R:R:L46	12.8239	3.65	Yes	No	2	8	9
26	R:R:L46	R:R:N45	11.7158	6.87	No	No	0	9	6
27	R:R:D43	R:R:N45	10.429	6.73	Yes	No	0	7	6
28	R:R:F40	R:R:L55	18.5702	10.96	No	No	0	8	7
29	R:R:I59	R:R:L55	19.1689	4.28	No	No	0	6	7
30	R:R:F63	R:R:I59	19.7587	3.77	No	No	0	6	6
31	R:R:F40	R:R:R47	15.277	6.41	No	No	0	8	8
32	R:R:R47	R:R:Y52	12.9178	5.14	No	No	0	8	6
33	R:R:F54	R:R:I108	51.9571	6.28	Yes	No	0	8	9
34	R:R:F53	R:R:I108	50.9607	5.02	No	No	0	8	9
35	R:R:D111	R:R:F53	48.9634	3.58	No	No	0	9	8
36	R:R:D111	R:R:Y122	46.9258	11.49	No	No	0	9	8
37	R:R:R49	R:R:Y122	45.0357	10.29	No	No	0	7	8
38	R:R:Q125	R:R:R49	39.8838	7.01	No	No	0	5	7
39	R:R:I129	R:R:Y52	10.3709	3.63	No	No	0	4	6
40	R:R:I151	R:R:Y95	20.7149	4.84	Yes	Yes	1	7	8
41	L:L:?1	R:R:Y95	52.6452	13.36	Yes	Yes	1	0	8
42	R:R:P166	R:R:Y95	16.3315	6.95	Yes	Yes	1	7	8
43	R:R:N147	R:R:Y95	13.1948	9.3	No	Yes	1	8	8
44	R:R:V102	R:R:W316	10.9964	8.58	Yes	Yes	1	8	9
45	R:R:F312	R:R:W316	12.5514	10.02	Yes	Yes	1	9	9
46	R:R:Q125	R:R:S121	38.807	4.33	No	No	0	5	5
47	R:R:N118	R:R:S121	37.7122	4.47	No	No	0	6	5
48	R:R:N118	R:R:S117	36.6086	5.96	No	No	0	6	7
49	R:R:S117	R:R:Y196	35.4915	6.36	No	No	0	7	6
50	R:R:Y113	R:R:Y196	34.5353	10.92	No	No	0	9	6
51	R:R:F193	R:R:Y113	30.8847	7.22	Yes	No	3	7	9
52	R:R:F193	R:R:S109	26.4343	5.28	Yes	No	0	7	9
53	R:R:S109	R:R:V190	25.2413	6.46	No	No	0	9	9
54	R:R:N194	R:R:V190	20.3798	2.96	No	No	0	9	9
55	R:R:L305	R:R:N194	19.1421	6.87	No	No	0	8	9
56	R:R:F168	R:R:N147	12.319	6.04	Yes	No	1	6	8
57	R:R:F168	R:R:I151	13.0652	3.77	Yes	Yes	1	6	7
58	R:R:F168	R:R:P166	14.2002	11.56	Yes	Yes	1	6	7
59	R:R:F168	R:R:I174	16.9392	6.28	Yes	No	1	6	8
60	R:R:F168	R:R:S154	14.16	7.93	Yes	No	0	6	8
61	R:R:Y319	R:R:Y340	26.6577	10.92	Yes	No	0	7	5
62	L:L:?1	R:R:Y319	18.2708	4.77	Yes	Yes	1	0	7
63	R:R:I174	R:R:Y173	14.16	6.04	No	No	0	8	4
64	R:R:C315	R:R:N350	10.4468	12.6	Yes	No	0	8	9
65	R:R:F322	R:R:Y340	21.059	8.25	Yes	No	0	6	5
66	R:R:F322	R:R:R334	15.3441	4.28	Yes	Yes	4	6	1
67	R:R:F365	R:R:F40	10.63	3.22	Yes	No	0	8	8
68	R:R:Q347	R:R:Y319	14.3029	9.02	No	Yes	1	8	7
69	R:R:Q347	R:R:W316	14.79	13.14	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D94	R:R:S68	8.83	1	No	No	8	8	1	2
R:R:S68	R:R:W348	7.41	1	No	Yes	8	8	2	1
R:R:F344	R:R:Y72	11.35	1	Yes	Yes	6	7	1	2
R:R:W345	R:R:Y72	5.79	1	No	Yes	8	7	2	2
R:R:W348	R:R:Y72	6.75	1	Yes	Yes	8	7	1	2
R:R:L91	R:R:Y95	3.52	1	No	Yes	6	8	2	1
R:R:L91	R:R:P166	3.28	1	No	Yes	6	7	2	2
R:R:D94	R:R:W348	11.17	1	No	Yes	8	8	1	1
L:L:?1	R:R:D94	12.15	1	Yes	No	0	8	0	1
R:R:N147	R:R:Y95	9.3	1	No	Yes	8	8	2	1
R:R:I151	R:R:Y95	4.84	1	Yes	Yes	7	8	2	1
R:R:P166	R:R:Y95	6.95	1	Yes	Yes	7	8	2	1
L:L:?1	R:R:Y95	13.36	1	Yes	Yes	0	8	0	1
R:R:C98	R:R:W316	3.92	1	No	Yes	8	9	1	1
L:L:?1	R:R:C98	6.46	1	Yes	No	0	8	0	1
R:R:V102	R:R:Y103	3.79	1	Yes	Yes	8	7	2	2
R:R:F312	R:R:V102	3.93	1	Yes	Yes	9	8	2	2
R:R:V102	R:R:W316	8.58	1	Yes	Yes	8	9	2	1
R:R:V146	R:R:Y103	6.31	1	No	Yes	7	7	2	2
R:R:E182	R:R:Y103	3.37	1	Yes	Yes	8	7	1	2
R:R:E182	R:R:V146	4.28	1	Yes	No	8	7	1	2
R:R:I151	R:R:N147	7.08	1	Yes	No	7	8	2	2
R:R:E182	R:R:T178	7.06	1	Yes	No	8	8	1	2
L:L:?1	R:R:E182	5.39	1	Yes	Yes	0	8	0	1
R:R:F312	R:R:W316	10.02	1	Yes	Yes	9	9	2	1
R:R:Q347	R:R:W316	13.14	1	No	Yes	8	9	1	1
R:R:N350	R:R:W316	7.91	0	No	Yes	9	9	2	1
L:L:?1	R:R:W316	5.56	1	Yes	Yes	0	9	0	1
R:R:T323	R:R:Y319	8.74	0	No	Yes	7	7	2	1
R:R:Y319	R:R:Y340	10.92	1	Yes	No	7	5	1	2
R:R:F344	R:R:Y319	6.19	1	Yes	Yes	6	7	1	1
R:R:Q347	R:R:Y319	9.02	1	No	Yes	8	7	1	1
L:L:?1	R:R:Y319	4.77	1	Yes	Yes	0	7	0	1
R:R:F344	R:R:W348	8.02	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:F344	16.86	1	Yes	Yes	0	6	0	1
R:R:W345	R:R:W348	11.25	1	No	Yes	8	8	2	1
L:L:?1	R:R:Q347	11.92	1	Yes	No	0	8	0	1
L:L:?1	R:R:W348	12.05	1	Yes	Yes	0	8	0	1
R:R:A343	R:R:Y319	2.67	0	No	Yes	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HOC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	253
Number of Links	275
Number of Hubs	27
Number of Links mediated by Hubs	104
Number of Communities	4
Number of Nodes involved in Communities	37
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	40223
Length Of Smallest Path	3
Average Path Length	16.0735
Length of Longest Path	44
Minimum Path Strength	1.325
Average Path Strength	6.25367
Maximum Path Strength	15.11
Minimum Path Correlation	0.7
Average Path Correlation	0.919791
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.38095
Average % Of Corr. Nodes	45.2368
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.3258
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ITF
Name	2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate
Synonyms
Identifier
Formula	C6 H10 N4 S
Molecular Weight	170.235
SMILES
PubChem	3692
Formal Charge	0
Total Atoms	21
Total Chiral Atoms	0
Total Bonds	21
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>8HOC_nogp_Chain_R S T R I T L A F L M S L L A F A I M L G N A V V I L A F V V D K N L R H R S N Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y Q S V S N A V S Y R T Q H T G I L K I V T L M V A V W V L A F L V N G P M I L V S E S W K D E G S E C E P G F F S E W Y I L A I T S F L E F L V P V I L V A Y F N M Y I Y W S L W K R G H L E L L R A R K L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y P S A T R P K S V W Y R I A F W L Q W F N S F V N P F L Y P L C H K R F Q K A F L K I F C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	9LRC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	-	2.84	2025-06-11	To be published
	9LRE	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.84	2025-06-11	To be published
	9LRE (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.84	2025-06-11	To be published
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HOC_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.