psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L10	R:R:T14	10.32	No	No	0	3	5
2	R:R:L10	R:R:R15	6.07	No	No	0	3	3
3	R:R:S11	R:R:T14	6.4	No	No	0	7	5
4	R:R:L12	R:R:V16	2.98	No	No	0	3	5
5	R:R:E79	R:R:R15	9.3	No	No	0	3	3
6	R:R:F21	R:R:T17	3.89	No	No	0	4	3
7	R:R:L18	R:R:L77	6.92	No	No	0	5	6
8	R:R:I73	R:R:M22	8.75	No	No	0	6	7
9	R:R:M22	R:R:W345	12.8	No	Yes	0	7	8
10	R:R:I73	R:R:S23	3.1	No	No	0	6	5
11	R:R:I29	R:R:V25	3.07	No	No	0	8	7
12	R:R:F349	R:R:V25	3.93	No	No	0	4	7
13	R:R:A26	R:R:I69	4.87	No	Yes	0	7	8
14	R:R:F27	R:R:L31	3.65	No	No	0	5	4
15	R:R:G65	R:R:I29	3.53	No	No	0	8	8
16	R:R:F352	R:R:I29	3.77	No	No	0	6	8
17	R:R:F62	R:R:M30	4.98	Yes	No	5	8	6
18	R:R:M30	R:R:V66	6.09	No	No	5	6	5
19	R:R:A58	R:R:N33	4.69	No	No	0	9	9
20	R:R:D61	R:R:N33	10.77	Yes	No	0	9	9
21	R:R:N33	R:R:P355	8.15	No	No	0	9	9
22	R:R:F373	R:R:L35	6.09	No	No	0	7	8
23	R:R:A58	R:R:V36	3.39	No	No	0	9	9
24	R:R:P359	R:R:V36	7.07	No	No	0	8	9
25	R:R:I37	R:R:L55	4.28	No	No	0	8	7
26	R:R:L38	R:R:V42	2.98	No	No	6	4	6
27	R:R:I372	R:R:L38	4.28	Yes	No	6	6	4
28	R:R:A39	R:R:F369	4.16	No	No	0	8	8
29	R:R:F40	R:R:R47	16.03	No	No	7	8	8
30	R:R:F40	R:R:Y52	7.22	No	No	7	8	6
31	R:R:F40	R:R:L55	20.7	No	No	0	8	7
32	R:R:I372	R:R:V42	6.14	Yes	No	6	6	6
33	R:R:D43	R:R:N45	10.77	Yes	No	0	7	6
34	R:R:D43	R:R:L46	9.5	Yes	No	0	7	9
35	R:R:A368	R:R:D43	6.18	No	Yes	0	8	7
36	R:R:L46	R:R:S51	6.01	No	No	2	9	9
37	R:R:F365	R:R:L46	9.74	Yes	No	2	8	9
38	R:R:R47	R:R:Y52	9.26	No	No	7	8	6
39	R:R:H48	R:R:Y122	7.62	No	Yes	0	7	8
40	R:R:F53	R:R:R49	3.21	No	Yes	4	8	7
41	R:R:D111	R:R:R49	9.53	No	Yes	4	9	7
42	R:R:R49	R:R:Y122	6.17	Yes	Yes	4	7	8
43	R:R:Q125	R:R:R49	3.5	No	Yes	4	5	7
44	R:R:R49	R:R:T127	10.35	Yes	Yes	4	7	8
45	R:R:H362	R:R:S50	4.18	Yes	No	0	9	8
46	R:R:F365	R:R:S51	6.61	Yes	No	2	8	9
47	R:R:I132	R:R:Y52	8.46	No	No	0	7	6
48	R:R:F53	R:R:L107	14.61	No	No	0	8	8
49	R:R:D111	R:R:F53	10.75	No	No	4	9	8
50	R:R:F54	R:R:I108	7.54	Yes	No	0	8	9
51	R:R:F54	R:R:Y358	3.09	Yes	Yes	2	8	9
52	R:R:F54	R:R:P359	5.78	Yes	No	0	8	8
53	R:R:F54	R:R:H362	4.53	Yes	Yes	2	8	9
54	R:R:F365	R:R:F54	8.57	Yes	Yes	2	8	8
55	R:R:I59	R:R:L55	5.71	No	No	0	6	7
56	R:R:N104	R:R:N56	12.26	Yes	No	0	8	9
57	R:R:M136	R:R:N56	14.02	No	No	0	8	9
58	R:R:N56	R:R:W140	7.91	No	No	0	9	9
59	R:R:L57	R:R:S60	3	Yes	Yes	2	9	9
60	R:R:D61	R:R:L57	5.43	Yes	Yes	2	9	9
61	R:R:L57	R:R:N104	8.24	Yes	Yes	2	9	8
62	R:R:I105	R:R:L57	4.28	No	Yes	2	9	9
63	R:R:L57	R:R:N354	10.98	Yes	Yes	2	9	9
64	R:R:D61	R:R:S60	4.42	Yes	Yes	2	9	9
65	R:R:S101	R:R:S60	4.89	No	Yes	2	9	9
66	R:R:N104	R:R:S60	2.98	Yes	Yes	2	8	9
67	R:R:D61	R:R:S101	4.42	Yes	No	2	9	9
68	R:R:D61	R:R:S351	5.89	Yes	No	0	9	9
69	R:R:D61	R:R:N354	10.77	Yes	Yes	2	9	9
70	R:R:F62	R:R:F63	7.5	Yes	No	0	8	6
71	R:R:F62	R:R:V66	7.87	Yes	No	5	8	5
72	R:R:G65	R:R:V64	3.68	No	Yes	0	8	8
73	R:R:L97	R:R:V64	5.96	No	Yes	0	6	8
74	R:R:V64	R:R:W348	3.68	Yes	Yes	0	8	8
75	R:R:S351	R:R:V64	8.08	No	Yes	0	9	8
76	R:R:I67	R:R:V66	3.07	No	No	0	6	5
77	R:R:I67	R:R:T93	3.04	No	No	0	6	5
78	R:R:D94	R:R:S68	8.83	Yes	No	1	8	8
79	R:R:S68	R:R:W348	3.71	No	Yes	1	8	8
80	R:R:I69	R:R:P70	3.39	Yes	No	0	8	9
81	R:R:I69	R:R:W345	3.52	Yes	Yes	1	8	8
82	R:R:I69	R:R:W348	12.92	Yes	Yes	1	8	8
83	R:R:F82	R:R:L71	6.09	Yes	No	1	6	5
84	R:R:L71	R:R:W90	7.97	No	Yes	1	5	7
85	R:R:T76	R:R:Y72	11.24	No	Yes	0	5	7
86	R:R:W90	R:R:Y72	7.72	Yes	Yes	1	7	7
87	R:R:F344	R:R:Y72	9.28	Yes	Yes	1	6	7
88	R:R:W345	R:R:Y72	5.79	Yes	Yes	1	8	7
89	R:R:W348	R:R:Y72	8.68	Yes	Yes	1	8	7
90	R:R:I73	R:R:P74	3.39	No	No	0	6	5
91	R:R:P74	R:R:W80	5.4	No	No	0	5	9
92	R:R:F82	R:R:H75	21.5	Yes	No	0	6	6
93	R:R:F82	R:R:W80	9.02	Yes	No	0	6	9
94	R:R:F82	R:R:W90	6.01	Yes	Yes	1	6	7
95	R:R:G83	R:R:I86	3.53	No	No	0	7	5
96	R:R:K158	R:R:K84	4.31	No	No	0	6	3
97	R:R:C87	R:R:L91	3.17	No	Yes	1	9	6
98	R:R:C164	R:R:C87	7.28	No	No	1	9	9
99	R:R:E155	R:R:V88	7.13	No	No	0	6	7
100	R:R:F89	R:R:T93	7.78	No	No	0	4	5
101	R:R:L91	R:R:W90	3.42	Yes	Yes	1	6	7
102	R:R:C164	R:R:L91	3.17	No	Yes	1	9	6
103	R:R:L91	R:R:P166	4.93	Yes	Yes	1	6	7
104	R:R:D94	R:R:Y95	4.6	Yes	Yes	1	8	8
105	R:R:C98	R:R:D94	3.11	No	Yes	1	8	8
106	R:R:D94	R:R:W348	10.05	Yes	Yes	1	8	8
107	L:L:?1	R:R:D94	14.05	Yes	Yes	1	0	8
108	R:R:N147	R:R:Y95	16.28	Yes	Yes	1	8	8
109	R:R:I151	R:R:Y95	4.84	No	Yes	0	7	8
110	R:R:P166	R:R:Y95	9.74	Yes	Yes	1	7	8
111	L:L:?1	R:R:Y95	14.34	Yes	Yes	1	0	8
112	R:R:L96	R:R:W140	5.69	No	No	0	6	9
113	R:R:C98	R:R:Q347	3.05	No	Yes	1	8	8
114	L:L:?1	R:R:C98	7.47	Yes	No	1	0	8
115	R:R:T99	R:R:Y103	8.74	Yes	Yes	1	8	7
116	R:R:A143	R:R:T99	3.36	No	Yes	0	8	8
117	R:R:T99	R:R:V146	3.17	Yes	Yes	1	8	7
118	R:R:N147	R:R:T99	4.39	Yes	Yes	1	8	8
119	R:R:A100	R:R:W140	6.48	No	No	0	8	9
120	R:R:V102	R:R:Y103	3.79	Yes	Yes	1	8	7
121	R:R:P186	R:R:V102	3.53	No	Yes	0	9	8
122	R:R:F312	R:R:V102	5.24	No	Yes	1	9	8
123	R:R:V102	R:R:W316	8.58	Yes	Yes	1	8	9
124	R:R:V146	R:R:Y103	5.05	Yes	Yes	1	7	7
125	R:R:N104	R:R:V139	7.39	Yes	No	0	8	8
126	R:R:I105	R:R:N354	7.08	No	Yes	2	9	9
127	R:R:I105	R:R:Y358	9.67	No	Yes	2	9	9
128	R:R:P186	R:R:V106	3.53	No	No	0	9	7
129	R:R:L189	R:R:V106	2.98	No	No	0	7	7
130	R:R:L107	R:R:V139	2.98	No	No	0	8	8
131	R:R:I108	R:R:R112	3.76	No	No	0	9	9
132	R:R:S109	R:R:V190	6.46	No	No	3	9	9
133	R:R:F193	R:R:S109	3.96	Yes	No	3	7	9
134	R:R:N194	R:R:S109	2.98	No	No	3	9	9
135	R:R:L114	R:R:Y110	16.41	No	No	0	5	6
136	R:R:F193	R:R:Y110	10.32	Yes	No	0	7	6
137	R:R:D111	R:R:Y122	10.34	No	Yes	4	9	8
138	R:R:L308	R:R:R112	3.64	No	No	2	8	9
139	R:R:R112	R:R:Y358	7.2	No	Yes	2	9	9
140	R:R:S117	R:R:Y113	10.17	No	Yes	0	7	9
141	R:R:Y113	R:R:Y192	3.97	Yes	No	3	9	5
142	R:R:F193	R:R:Y113	10.32	Yes	Yes	3	7	9
143	R:R:N196	R:R:Y113	6.98	No	Yes	3	6	9
144	R:R:S115	R:R:V116	3.23	No	No	0	8	8
145	R:R:S115	R:R:Y122	8.9	No	Yes	0	8	8
146	R:R:I197	R:R:V116	4.61	No	No	0	9	8
147	R:R:S200	R:R:V116	4.85	No	No	0	6	8
148	R:R:N118	R:R:S117	4.47	No	No	0	6	7
149	R:R:Q125	R:R:T127	4.25	No	Yes	4	5	8
150	R:R:K131	R:R:T127	3	No	Yes	0	7	8
151	R:R:I132	R:R:T127	3.04	No	Yes	0	7	8
152	R:R:L145	R:R:V141	2.98	No	No	0	4	4
153	R:R:F144	R:R:G148	3.01	No	Yes	8	5	5
154	R:R:F144	R:R:P149	7.22	No	No	8	5	8
155	R:R:N147	R:R:V146	5.91	Yes	Yes	1	8	7
156	R:R:N147	R:R:T178	4.39	Yes	No	1	8	8
157	R:R:E182	R:R:N147	5.26	Yes	Yes	1	8	8
158	R:R:G148	R:R:P149	4.06	Yes	No	8	5	8
159	R:R:G148	R:R:I151	3.53	Yes	No	0	5	7
160	R:R:F168	R:R:M150	3.73	Yes	No	0	6	7
161	R:R:F168	R:R:I151	3.77	Yes	No	0	6	7
162	R:R:S154	R:R:W157	7.41	No	No	0	8	6
163	R:R:G167	R:R:S154	3.71	No	No	0	6	8
164	R:R:F168	R:R:S154	6.61	Yes	No	0	6	8
165	R:R:E155	R:R:K158	13.5	No	No	0	6	6
166	R:R:G167	R:R:K158	3.49	No	No	0	6	6
167	R:R:E165	R:R:F169	3.5	No	Yes	0	4	6
168	R:R:E165	R:R:K336	9.45	No	No	0	4	4
169	R:R:F168	R:R:P166	10.11	Yes	Yes	1	6	7
170	R:R:F169	R:R:P166	14.45	Yes	Yes	1	6	7
171	R:R:F168	R:R:F169	6.43	Yes	Yes	1	6	6
172	R:R:F168	R:R:I174	7.54	Yes	No	1	6	8
173	R:R:F168	R:R:L175	4.87	Yes	Yes	1	6	7
174	R:R:F169	R:R:L175	9.74	Yes	Yes	1	6	7
175	R:R:F169	R:R:T323	9.08	Yes	Yes	1	6	7
176	R:R:F169	R:R:Y340	3.09	Yes	Yes	1	6	5
177	R:R:E171	R:R:S170	7.19	No	No	0	6	3
178	R:R:E171	R:R:Y173	15.71	No	No	1	6	4
179	R:R:E171	R:R:I174	4.1	No	No	1	6	8
180	R:R:F328	R:R:W172	4.01	No	No	0	5	4
181	R:R:I174	R:R:Y173	4.84	No	No	1	8	4
182	R:R:L175	R:R:T323	5.9	Yes	Yes	1	7	7
183	R:R:L175	R:R:S327	3	Yes	No	0	7	6
184	R:R:E182	R:R:T178	5.64	Yes	No	1	8	8
185	R:R:S179	R:R:S320	6.52	No	No	1	8	8
186	R:R:I324	R:R:S179	4.64	No	No	1	6	8
187	R:R:F180	R:R:V184	7.87	No	No	0	4	7
188	R:R:F180	R:R:I185	12.56	No	No	0	4	6
189	R:R:E182	R:R:W316	10.9	Yes	Yes	1	8	9
190	R:R:F183	R:R:V187	5.24	No	No	0	9	6
191	R:R:F183	R:R:W316	6.01	No	Yes	0	9	9
192	R:R:A317	R:R:F183	4.16	No	No	0	7	9
193	R:R:I188	R:R:V184	3.07	No	No	0	4	7
194	R:R:I185	R:R:P186	3.39	No	No	0	6	9
195	R:R:F312	R:R:V187	5.24	No	No	0	9	6
196	R:R:F193	R:R:L189	4.87	Yes	No	0	7	7
197	R:R:N194	R:R:V190	4.43	No	No	3	9	9
198	R:R:L309	R:R:V190	2.98	No	No	0	8	9
199	R:R:A191	R:R:L309	3.15	No	No	0	5	8
200	R:R:F193	R:R:Y192	4.13	Yes	No	3	7	5
201	R:R:N196	R:R:Y192	13.96	No	No	3	6	5
202	R:R:L305	R:R:N194	12.36	No	No	0	8	9
203	R:R:M195	R:R:W199	10.47	No	Yes	0	3	4
204	R:R:N196	R:R:W199	5.65	No	Yes	3	6	4
205	R:R:L301	R:R:Y198	4.69	No	No	0	8	7
206	R:R:A302	R:R:Y198	5.34	No	No	0	7	7
207	R:R:W199	R:R:W202	4.69	Yes	No	3	4	6
208	R:R:K203	R:R:W199	3.48	No	Yes	3	6	4
209	R:R:D205	R:R:L201	9.5	Yes	No	0	5	8
210	R:R:L201	R:R:L301	6.92	No	No	0	8	8
211	R:R:K203	R:R:W202	8.12	No	No	3	6	6
212	R:R:D205	R:R:E294	16.89	Yes	No	9	5	5
213	R:R:D205	R:R:R297	5.96	Yes	Yes	9	5	7
214	R:R:H292	R:R:L296	14.14	No	No	0	5	4
215	R:R:E294	R:R:R297	11.63	No	Yes	9	5	7
216	R:R:L296	R:R:R299	3.64	No	No	0	4	6
217	R:R:L301	R:R:L305	5.54	No	No	0	8	8
218	R:R:I307	R:R:K303	5.82	No	No	0	7	7
219	R:R:L308	R:R:Y358	9.38	No	Yes	2	8	9
220	R:R:L357	R:R:V311	4.47	No	No	0	8	6
221	R:R:F312	R:R:W316	7.02	No	Yes	1	9	9
222	R:R:C315	R:R:N350	12.6	No	No	0	8	9
223	R:R:Q347	R:R:W316	21.9	Yes	Yes	1	8	9
224	R:R:L346	R:R:P318	4.93	No	No	0	8	9
225	R:R:T323	R:R:Y319	8.74	Yes	Yes	1	7	7
226	R:R:Y319	R:R:Y340	12.91	Yes	Yes	1	7	5
227	R:R:F344	R:R:Y319	9.28	Yes	Yes	1	6	7
228	R:R:Q347	R:R:Y319	6.76	Yes	Yes	1	8	7
229	L:L:?1	R:R:Y319	6.62	Yes	Yes	1	0	7
230	R:R:I324	R:R:S320	3.1	No	No	1	6	8
231	R:R:F322	R:R:L326	7.31	Yes	No	0	6	5
232	R:R:F322	R:R:Y340	4.13	Yes	Yes	0	6	5
233	R:R:T323	R:R:Y340	6.24	Yes	Yes	1	7	5
234	R:R:L326	R:R:S331	3	No	No	0	5	3
235	R:R:F328	R:R:Y329	6.19	No	No	0	5	5
236	R:R:G334	R:R:P335	4.06	No	No	0	1	4
237	R:R:K336	R:R:Y340	15.53	No	Yes	0	4	5
238	R:R:K336	R:R:R341	7.43	No	No	0	4	6
239	R:R:I342	R:R:V338	3.07	No	No	0	5	1
240	R:R:F344	R:R:W348	9.02	Yes	Yes	1	6	8
241	L:L:?1	R:R:F344	27.51	Yes	Yes	1	0	6
242	R:R:W345	R:R:W348	12.18	Yes	Yes	1	8	8
243	R:R:F349	R:R:W345	5.01	No	Yes	0	4	8
244	L:L:?1	R:R:Q347	26.31	Yes	Yes	1	0	8
245	L:L:?1	R:R:W348	11.79	Yes	Yes	1	0	8
246	R:R:N350	R:R:N354	5.45	No	Yes	0	9	9
247	R:R:L357	R:R:V353	4.47	No	No	0	8	7
248	R:R:H362	R:R:R364	11.28	Yes	No	0	9	7
249	R:R:F365	R:R:H362	3.39	Yes	Yes	2	8	9
250	R:R:K363	R:R:Q366	10.85	No	No	0	5	9
251	R:R:F365	R:R:F369	6.43	Yes	No	0	8	8
252	R:R:F373	R:R:I372	3.77	No	Yes	0	7	6
253	R:R:L18	R:R:T14	2.95	No	No	0	5	5
254	R:R:L97	R:R:T93	2.95	No	No	0	6	5
255	R:R:I177	R:R:L181	2.85	No	No	0	5	5
256	R:R:L77	R:R:M22	2.83	No	No	0	6	7
257	R:R:E165	R:R:T333	2.82	No	No	0	4	6
258	R:R:A19	R:R:F78	2.77	No	No	0	5	5
259	R:R:A28	R:R:F352	2.77	No	No	0	4	6
260	R:R:L31	R:R:L35	2.77	No	No	0	4	8
261	R:R:A34	R:R:F62	2.77	No	Yes	0	4	8
262	R:R:D43	R:R:K371	2.77	Yes	No	0	7	5
263	R:R:L107	R:R:L135	2.77	No	No	0	8	7
264	R:R:A332	R:R:F169	2.77	No	Yes	0	1	6
265	R:R:L308	R:R:L357	2.77	No	No	0	8	8
266	R:R:L356	R:R:L360	2.77	No	No	0	6	6
267	R:R:A298	R:R:Y198	2.67	No	No	0	8	7
268	R:R:A343	R:R:Y319	2.67	No	Yes	0	5	7
269	R:R:V325	R:R:Y329	2.52	No	No	0	6	5
270	R:R:K44	R:R:R47	2.48	No	No	0	7	8
271	R:R:S327	R:R:W172	2.47	No	No	0	6	4
272	R:R:F78	R:R:L77	2.44	No	No	0	5	6
273	R:R:F352	R:R:L356	2.44	No	No	0	6	6
274	R:R:F369	R:R:L360	2.44	No	No	0	8	6
275	R:R:I342	R:R:W339	2.35	No	No	0	5	5
276	R:R:L142	R:R:Y103	2.34	No	Yes	0	5	7
277	R:R:F322	R:R:W339	2	Yes	No	0	6	5
278	R:R:A317	R:R:P318	1.87	No	No	0	7	9
279	R:R:A343	R:R:P318	1.87	No	No	0	5	9
280	R:R:G148	R:R:T92	1.82	Yes	No	0	5	6
281	R:R:G32	R:R:L31	1.71	No	No	0	8	4
282	R:R:G310	R:R:L309	1.71	No	No	0	6	8
283	R:R:L145	R:R:P149	1.64	No	No	0	4	8
284	R:R:E160	R:R:G161	1.64	No	No	0	3	1
285	R:R:E163	R:R:G334	1.64	No	No	0	4	1
286	R:R:S11	R:R:S13	1.63	No	No	0	7	2
287	R:R:A39	R:R:I372	1.62	No	Yes	0	8	6
288	R:R:S13	R:R:T17	1.6	No	No	0	2	3
289	R:R:V129	R:R:V133	1.6	No	No	0	4	3
290	R:R:V133	R:R:V137	1.6	No	No	0	3	4
291	R:R:V137	R:R:V141	1.6	No	No	0	4	4
292	R:R:T124	R:R:V120	1.59	No	No	0	5	7
293	R:R:G128	R:R:H126	1.59	No	No	0	4	7
294	R:R:A317	R:R:L321	1.58	No	No	0	7	6
295	R:R:I37	R:R:V41	1.54	No	No	0	8	3
296	R:R:I307	R:R:V311	1.54	No	No	0	7	6
297	R:R:F82	R:R:G83	1.51	Yes	No	0	6	7
298	R:R:L152	R:R:V88	1.49	No	No	0	5	7
299	R:R:N118	R:R:S121	1.49	No	No	0	6	5
300	R:R:L181	R:R:V146	1.49	No	Yes	0	5	7
301	R:R:E182	R:R:S179	1.44	Yes	No	1	8	8
302	R:R:K363	R:R:K367	1.44	No	No	0	5	5
303	R:R:E163	R:R:T333	1.41	No	No	0	4	6
304	R:R:F322	R:R:S337	1.32	Yes	No	0	6	2
305	R:R:R297	R:R:V293	1.31	Yes	No	0	7	5
306	R:R:R123	R:R:T124	1.29	No	No	0	5	5
307	R:R:E291	R:R:E294	1.27	No	No	0	5	5
308	R:R:S156	R:R:W157	1.24	No	No	0	5	6
309	R:R:V153	R:R:W157	1.23	No	No	0	5	6
310	R:R:F20	R:R:L24	1.22	No	No	0	4	5
311	R:R:L296	R:R:R300	1.21	No	No	0	4	8
312	R:R:D205	R:R:R204	1.19	Yes	No	0	5	8
313	R:R:E291	R:R:R290	1.16	No	No	0	5	5
314	R:R:R297	R:R:R300	1.07	Yes	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D43	7.305	4	0	7
2	R:R:R49	6.552	5	4	7
3	R:R:F54	5.902	5	2	8
4	R:R:L57	6.386	5	2	9
5	R:R:S60	3.8225	4	2	9
6	R:R:D61	6.95	6	2	9
7	R:R:F62	5.78	4	5	8
8	R:R:V64	5.35	4	0	8
9	R:R:I69	6.175	4	1	8
10	R:R:Y72	8.542	5	1	7
11	R:R:F82	8.826	5	1	6
12	R:R:W90	6.28	4	1	7
13	R:R:L91	3.6725	4	1	6
14	R:R:D94	8.128	5	1	8
15	R:R:Y95	9.96	5	1	8
16	R:R:T99	4.915	4	1	8
17	R:R:V102	5.285	4	1	8
18	R:R:Y103	4.98	4	1	7
19	R:R:N104	7.7175	4	2	8
20	R:R:Y113	7.86	4	3	9
21	R:R:Y122	8.2575	4	4	8
22	R:R:T127	5.16	4	4	8
23	R:R:V146	3.905	4	1	7
24	R:R:N147	7.246	5	1	8
25	R:R:G148	3.105	4	8	5
26	R:R:P166	9.8075	4	1	7
27	R:R:F168	6.15143	7	1	6
28	R:R:F169	7.00857	7	1	6
29	R:R:L175	5.8775	4	1	7
30	R:R:E182	5.81	4	1	8
31	R:R:F193	6.72	5	3	7
32	R:R:W199	6.0725	4	3	4
33	R:R:D205	8.385	4	9	5
34	R:R:R297	4.9925	4	9	7
35	R:R:W316	10.882	5	1	9
36	R:R:Y319	7.83	6	1	7
37	R:R:F322	3.69	4	0	6
38	R:R:T323	7.49	4	1	7
39	R:R:Y340	8.38	5	1	5
40	R:R:F344	13.7725	4	1	6
41	R:R:W345	7.86	5	1	8
42	R:R:Q347	14.505	4	1	8
43	R:R:W348	9.00375	8	1	8
44	R:R:N354	8.57	4	2	9
45	R:R:Y358	7.335	4	2	9
46	R:R:H362	5.845	4	2	9
47	R:R:F365	6.948	5	2	8
48	R:R:I372	3.9525	4	6	6
49	L:L:?1	15.4414	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L77	R:R:M22	12.4857	2.83	No	No	0	6	7
2	R:R:M22	R:R:W345	15.9658	12.8	No	Yes	0	7	8
3	R:R:F369	R:R:L360	12.3355	2.44	No	No	0	8	6
4	R:R:L356	R:R:L360	12.871	2.77	No	No	0	6	6
5	R:R:F352	R:R:L356	13.5746	2.44	No	No	0	6	6
6	R:R:F352	R:R:I29	15.1437	3.77	No	No	0	6	8
7	R:R:G65	R:R:V64	15.3294	3.68	No	Yes	0	8	8
8	R:R:V64	R:R:W348	100	3.68	Yes	Yes	0	8	8
9	R:R:W345	R:R:W348	14.786	12.18	Yes	Yes	1	8	8
10	R:R:D61	R:R:S351	83.2813	5.89	Yes	No	0	9	9
11	R:R:S351	R:R:V64	83.6726	8.08	No	Yes	0	9	8
12	R:R:I132	R:R:Y52	11.6833	8.46	No	No	0	7	6
13	R:R:I132	R:R:T127	13.1378	3.04	No	Yes	0	7	8
14	R:R:R49	R:R:T127	15.9223	10.35	Yes	Yes	4	7	8
15	R:R:F53	R:R:R49	27.0325	3.21	No	Yes	4	8	7
16	R:R:F53	R:R:L107	38.3384	14.61	No	No	0	8	8
17	R:R:L107	R:R:V139	41.1328	2.98	No	No	0	8	8
18	R:R:N104	R:R:V139	42.5161	7.39	Yes	No	0	8	8
19	R:R:L57	R:R:N104	26.6689	8.24	Yes	Yes	2	9	8
20	R:R:D61	R:R:L57	38.8621	5.43	Yes	Yes	2	9	9
21	R:R:N104	R:R:S60	24.0623	2.98	Yes	Yes	2	8	9
22	R:R:D61	R:R:S60	24.6018	4.42	Yes	Yes	2	9	9
23	R:R:F365	R:R:L46	10.4028	9.74	Yes	No	2	8	9
24	R:R:F54	R:R:Y358	17.8689	3.09	Yes	Yes	2	8	9
25	R:R:I105	R:R:Y358	30.0502	9.67	No	Yes	2	9	9
26	R:R:I105	R:R:L57	16.9302	4.28	No	Yes	2	9	9
27	R:R:I105	R:R:N354	14.4718	7.08	No	Yes	2	9	9
28	R:R:D61	R:R:N354	16.2978	10.77	Yes	Yes	2	9	9
29	R:R:D94	R:R:W348	24.7125	10.05	Yes	Yes	1	8	8
30	R:R:F344	R:R:W348	15.6199	9.02	Yes	Yes	1	6	8
31	R:R:G167	R:R:K158	14.1457	3.49	No	No	0	6	6
32	R:R:G167	R:R:S154	17.023	3.71	No	No	0	6	8
33	R:R:F168	R:R:S154	28.4929	6.61	Yes	No	0	6	8
34	R:R:F168	R:R:I151	20.0407	3.77	Yes	No	0	6	7
35	R:R:I151	R:R:Y95	31.23	4.84	No	Yes	0	7	8
36	R:R:D94	R:R:Y95	24.4081	4.6	Yes	Yes	1	8	8
37	R:R:F168	R:R:P166	20.4063	10.11	Yes	Yes	1	6	7
38	R:R:P166	R:R:Y95	27.6807	9.74	Yes	Yes	1	7	8
39	L:L:?1	R:R:Y95	29.9692	14.34	Yes	Yes	1	0	8
40	L:L:?1	R:R:W348	63.9856	11.79	Yes	Yes	1	0	8
41	R:R:N147	R:R:Y95	28.1234	16.28	Yes	Yes	1	8	8
42	L:L:?1	R:R:Q347	30.6075	26.31	Yes	Yes	1	0	8
43	R:R:Q347	R:R:W316	41.0537	21.9	Yes	Yes	1	8	9
44	R:R:V102	R:R:W316	40.7612	8.58	Yes	Yes	1	8	9
45	R:R:V102	R:R:Y103	10.8869	3.79	Yes	Yes	1	8	7
46	R:R:P186	R:R:V102	48.9684	3.53	No	Yes	0	9	8
47	R:R:P186	R:R:V106	44.2552	3.53	No	No	0	9	7
48	R:R:L189	R:R:V106	43.3007	2.98	No	No	0	7	7
49	R:R:F193	R:R:L189	42.3422	4.87	Yes	No	0	7	7
50	R:R:F193	R:R:S109	24.499	3.96	Yes	No	3	7	9
51	R:R:N194	R:R:S109	19.1494	2.98	No	No	3	9	9
52	R:R:S115	R:R:Y122	11.3928	8.9	No	Yes	0	8	8
53	R:R:G148	R:R:I151	12.1458	3.53	Yes	No	0	5	7
54	R:R:E165	R:R:F169	13.7623	3.5	No	Yes	0	4	6
55	R:R:T323	R:R:Y319	16.6614	8.74	Yes	Yes	1	7	7
56	R:R:F344	R:R:Y319	18.525	9.28	Yes	Yes	1	6	7
57	R:R:Y319	R:R:Y340	22.0643	12.91	Yes	Yes	1	7	5
58	L:L:?1	R:R:Y319	15.9065	6.62	Yes	Yes	1	0	7
59	R:R:F168	R:R:I174	11.5628	7.54	Yes	No	1	6	8
60	R:R:L305	R:R:N194	18.2384	12.36	No	No	0	8	9
61	R:R:L301	R:R:L305	17.1752	5.54	No	No	0	8	8
62	R:R:D205	R:R:L201	12.0311	9.5	Yes	No	0	5	8
63	R:R:L201	R:R:L301	13.0034	6.92	No	No	0	8	8
64	R:R:E163	R:R:T333	10.8889	1.41	No	No	0	4	6
65	R:R:E165	R:R:T333	14.5113	2.82	No	No	0	4	6
66	R:R:G65	R:R:I29	14.5231	3.53	No	No	0	8	8
67	R:R:F365	R:R:F54	11.0371	8.57	Yes	Yes	2	8	8
68	R:R:Q347	R:R:Y319	10.7407	6.76	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V64	R:R:W348	3.68	0	Yes	Yes	8	8	2	1
R:R:D94	R:R:S68	8.83	1	Yes	No	8	8	1	2
R:R:S68	R:R:W348	3.71	1	No	Yes	8	8	2	1
R:R:I69	R:R:W345	3.52	1	Yes	Yes	8	8	2	2
R:R:I69	R:R:W348	12.92	1	Yes	Yes	8	8	2	1
R:R:F344	R:R:Y72	9.28	1	Yes	Yes	6	7	1	2
R:R:W345	R:R:Y72	5.79	1	Yes	Yes	8	7	2	2
R:R:W348	R:R:Y72	8.68	1	Yes	Yes	8	7	1	2
R:R:D94	R:R:Y95	4.6	1	Yes	Yes	8	8	1	1
R:R:C98	R:R:D94	3.11	1	No	Yes	8	8	1	1
R:R:D94	R:R:W348	10.05	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:D94	14.05	1	Yes	Yes	0	8	0	1
R:R:N147	R:R:Y95	16.28	1	Yes	Yes	8	8	2	1
R:R:I151	R:R:Y95	4.84	0	No	Yes	7	8	2	1
R:R:P166	R:R:Y95	9.74	1	Yes	Yes	7	8	2	1
L:L:?1	R:R:Y95	14.34	1	Yes	Yes	0	8	0	1
R:R:C98	R:R:Q347	3.05	1	No	Yes	8	8	1	1
L:L:?1	R:R:C98	7.47	1	Yes	No	0	8	0	1
R:R:Q347	R:R:W316	21.9	1	Yes	Yes	8	9	1	2
R:R:T323	R:R:Y319	8.74	1	Yes	Yes	7	7	2	1
R:R:Y319	R:R:Y340	12.91	1	Yes	Yes	7	5	1	2
R:R:F344	R:R:Y319	9.28	1	Yes	Yes	6	7	1	1
R:R:Q347	R:R:Y319	6.76	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:Y319	6.62	1	Yes	Yes	0	7	0	1
R:R:T323	R:R:Y340	6.24	1	Yes	Yes	7	5	2	2
R:R:F344	R:R:W348	9.02	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:F344	27.51	1	Yes	Yes	0	6	0	1
R:R:W345	R:R:W348	12.18	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:Q347	26.31	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W348	11.79	1	Yes	Yes	0	8	0	1
R:R:A343	R:R:Y319	2.67	0	No	Yes	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9LRE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	264
Number of Links	314
Number of Hubs	49
Number of Links mediated by Hubs	165
Number of Communities	9
Number of Nodes involved in Communities	85
Number of Links involved in Communities	124

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	90114
Length Of Smallest Path	3
Average Path Length	14.6506
Length of Longest Path	35
Minimum Path Strength	1.14
Average Path Strength	7.05381
Maximum Path Strength	26.91
Minimum Path Correlation	0.7
Average Path Correlation	0.927949
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	46.9251
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.5083
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • MAPK cascade • regulation of cell communication • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • cell body • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	1H-Imidazole-4-ethanamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>9LRE_nogp_Chain_R L S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D K N L R H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N A V S Y R T Q H T G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K D E G S E C E P G F F S E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R D Q R E H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S S A T G P K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F Q K A F L K I F C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	9LRC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	-	2.84	2025-06-11	To be published
	9LRE	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.84	2025-06-11	To be published
	9LRE (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.84	2025-06-11	To be published
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9LRE_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.