psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D94	11.5	Yes	No	1	0	8
2	L:L:?1	R:R:Y95	13.24	Yes	Yes	1	0	8
3	L:L:?1	R:R:Y319	4.41	Yes	Yes	1	0	7
4	L:L:?1	R:R:F344	21.78	Yes	No	1	0	6
5	L:L:?1	R:R:Q347	6.26	Yes	No	1	0	8
6	L:L:?1	R:R:W348	11.79	Yes	Yes	1	0	8
7	L:L:?1	W:W:?1	4.5	Yes	Yes	1	0	0
8	R:R:L77	R:R:R15	4.86	Yes	No	2	6	3
9	R:R:F78	R:R:R15	7.48	No	No	2	5	3
10	R:R:F21	R:R:T17	5.19	No	No	0	4	3
11	R:R:F20	R:R:F21	4.29	No	No	0	4	4
12	R:R:I73	R:R:M22	13.12	No	No	0	6	7
13	R:R:M22	R:R:W345	3.49	No	No	0	7	8
14	R:R:A28	R:R:F352	2.77	No	No	0	4	6
15	R:R:I29	R:R:S351	3.1	No	No	0	8	9
16	R:R:F62	R:R:M30	3.73	Yes	No	3	8	6
17	R:R:M30	R:R:V66	4.56	No	No	3	6	5
18	R:R:L31	R:R:L35	2.77	No	No	0	4	8
19	R:R:D61	R:R:N33	6.73	Yes	No	0	9	9
20	R:R:F62	R:R:N33	4.83	Yes	No	0	8	9
21	R:R:N33	R:R:P355	4.89	No	No	0	9	9
22	R:R:A58	R:R:V36	3.39	No	No	0	9	9
23	R:R:F62	R:R:I37	3.77	Yes	No	0	8	8
24	R:R:L38	R:R:V42	2.98	No	No	0	4	6
25	R:R:A39	R:R:F369	4.16	No	No	0	8	8
26	R:R:F40	R:R:R47	3.21	No	No	0	8	8
27	R:R:F40	R:R:S51	2.64	No	Yes	0	8	9
28	R:R:F40	R:R:L55	9.74	No	No	0	8	7
29	R:R:I372	R:R:V42	6.14	No	No	0	6	6
30	R:R:D43	R:R:N45	8.08	No	No	0	7	6
31	R:R:D43	R:R:L46	10.86	No	No	0	7	9
32	R:R:A368	R:R:D43	3.09	No	No	0	8	7
33	R:R:L46	R:R:S51	6.01	No	Yes	5	9	9
34	R:R:F365	R:R:L46	3.65	No	No	5	8	9
35	R:R:H48	R:R:R49	4.51	No	No	0	7	7
36	R:R:H48	R:R:R364	3.39	No	No	0	7	7
37	R:R:F365	R:R:S51	5.28	No	Yes	5	8	9
38	R:R:I132	R:R:Y52	10.88	Yes	No	6	7	6
39	R:R:M136	R:R:Y52	3.59	No	No	6	8	6
40	R:R:F53	R:R:L107	4.87	No	No	0	8	8
41	R:R:D111	R:R:F53	4.78	No	No	0	9	8
42	R:R:F54	R:R:I108	6.28	No	No	0	8	9
43	R:R:F54	R:R:P359	4.33	No	No	0	8	8
44	R:R:F365	R:R:F54	4.29	No	No	0	8	8
45	R:R:I59	R:R:L55	2.85	No	No	0	6	7
46	R:R:N104	R:R:N56	12.26	No	No	0	8	9
47	R:R:M136	R:R:N56	7.01	No	No	0	8	9
48	R:R:N56	R:R:W140	12.43	No	No	0	9	9
49	R:R:D61	R:R:L57	6.79	Yes	Yes	4	9	9
50	R:R:L57	R:R:S101	3	Yes	No	4	9	9
51	R:R:L57	R:R:N104	5.49	Yes	No	0	9	8
52	R:R:I105	R:R:L57	2.85	No	Yes	0	9	9
53	R:R:A100	R:R:S60	3.42	No	No	7	8	9
54	R:R:S60	R:R:W140	4.94	No	No	7	9	9
55	R:R:D61	R:R:S101	7.36	Yes	No	4	9	9
56	R:R:D61	R:R:S351	10.31	Yes	No	0	9	9
57	R:R:D61	R:R:N354	4.04	Yes	No	0	9	9
58	R:R:F62	R:R:F63	4.29	Yes	No	0	8	6
59	R:R:F62	R:R:V66	5.24	Yes	No	3	8	5
60	R:R:G65	R:R:V64	3.68	No	No	0	8	8
61	R:R:L97	R:R:V64	4.47	No	No	0	6	8
62	R:R:I67	R:R:T93	6.08	No	No	0	6	5
63	R:R:D94	R:R:S68	5.89	No	No	1	8	8
64	R:R:S68	R:R:W348	4.94	No	Yes	1	8	8
65	R:R:I69	R:R:P70	3.39	No	No	0	8	9
66	R:R:T76	R:R:Y72	19.97	No	No	0	5	7
67	R:R:W90	R:R:Y72	9.65	Yes	No	0	7	7
68	R:R:I73	R:R:P74	3.39	No	No	0	6	5
69	R:R:I73	R:R:L77	2.85	No	Yes	0	6	6
70	R:R:F82	R:R:P74	7.22	Yes	No	0	6	5
71	R:R:H75	R:R:W80	6.35	No	No	8	6	9
72	R:R:F82	R:R:H75	24.89	Yes	No	8	6	6
73	R:R:E163	R:R:T76	4.23	No	No	0	4	5
74	R:R:F78	R:R:L77	18.27	No	Yes	2	5	6
75	R:R:F82	R:R:W80	8.02	Yes	No	8	6	9
76	R:R:G83	R:R:W80	5.63	No	No	0	7	9
77	R:R:F82	R:R:I86	15.07	Yes	No	0	6	5
78	R:R:E85	R:R:I86	6.83	No	No	0	3	5
79	R:R:C87	R:R:W157	2.61	No	No	0	9	6
80	R:R:C164	R:R:C87	7.28	No	No	0	9	9
81	R:R:F89	R:R:T93	6.49	No	No	0	4	5
82	R:R:L91	R:R:W90	3.42	Yes	Yes	1	6	7
83	R:R:C164	R:R:W90	2.61	No	Yes	1	9	7
84	R:R:I151	R:R:L91	7.14	No	Yes	0	7	6
85	R:R:C164	R:R:L91	4.76	No	Yes	1	9	6
86	R:R:L91	R:R:P166	4.93	Yes	Yes	1	6	7
87	R:R:L97	R:R:T93	2.95	No	No	0	6	5
88	R:R:D94	R:R:W348	12.28	No	Yes	1	8	8
89	R:R:N147	R:R:Y95	15.12	No	Yes	0	8	8
90	R:R:P166	R:R:Y95	6.95	Yes	Yes	1	7	8
91	R:R:F168	R:R:Y95	3.09	Yes	Yes	1	6	8
92	R:R:Y95	W:W:?1	8.09	Yes	Yes	1	8	0
93	R:R:C98	R:R:W316	2.61	No	Yes	0	8	9
94	R:R:C98	R:R:W348	2.61	No	Yes	0	8	8
95	R:R:A143	R:R:T99	3.36	No	No	0	8	8
96	R:R:E182	R:R:T99	2.82	Yes	No	0	8	8
97	R:R:A100	R:R:W140	5.19	No	No	7	8	9
98	R:R:E182	R:R:V102	4.28	Yes	Yes	1	8	8
99	R:R:P186	R:R:V102	3.53	Yes	Yes	1	9	8
100	R:R:F312	R:R:V102	7.87	Yes	Yes	1	9	8
101	R:R:V102	R:R:W316	7.36	Yes	Yes	1	8	9
102	R:R:N104	R:R:V139	4.43	No	No	0	8	8
103	R:R:I105	R:R:N354	5.66	No	No	0	9	9
104	R:R:I105	R:R:Y358	12.09	No	Yes	0	9	9
105	R:R:P186	R:R:V106	3.53	Yes	No	0	9	7
106	R:R:I108	R:R:Y358	3.63	No	Yes	0	9	9
107	R:R:S109	R:R:V190	3.23	No	No	0	9	9
108	R:R:F193	R:R:S109	6.61	Yes	No	0	7	9
109	R:R:L114	R:R:Y110	10.55	No	No	0	5	6
110	R:R:F193	R:R:Y110	6.19	Yes	No	0	7	6
111	R:R:D111	R:R:Y122	3.45	No	No	0	9	8
112	R:R:R112	R:R:Y358	3.09	No	Yes	0	9	9
113	R:R:S117	R:R:Y113	11.45	No	Yes	0	7	9
114	R:R:F193	R:R:Y113	4.13	Yes	Yes	0	7	9
115	R:R:N196	R:R:Y113	5.81	No	Yes	0	6	9
116	R:R:N118	R:R:S121	8.94	No	No	0	6	5
117	R:R:K131	R:R:T127	4.5	No	No	0	7	8
118	R:R:L130	R:R:V129	2.98	No	No	0	5	4
119	R:R:I132	R:R:M136	2.92	Yes	No	6	7	8
120	R:R:F144	R:R:G148	4.52	No	No	0	5	5
121	R:R:N147	R:R:V146	5.91	No	No	0	8	7
122	R:R:N147	R:R:T178	7.31	No	No	0	8	8
123	R:R:G148	R:R:P149	4.06	No	No	0	5	8
124	R:R:G167	R:R:S154	3.71	No	No	0	6	8
125	R:R:E155	R:R:S156	7.19	No	No	9	6	5
126	R:R:E155	R:R:K158	8.1	No	No	9	6	6
127	R:R:K158	R:R:S156	3.06	No	No	9	6	5
128	R:R:S162	R:R:W157	4.94	No	No	0	3	6
129	R:R:E163	R:R:E165	3.81	No	No	0	4	4
130	R:R:E165	R:R:P166	3.14	No	Yes	0	4	7
131	R:R:F168	R:R:P166	10.11	Yes	Yes	1	6	7
132	R:R:F169	R:R:P166	4.33	No	Yes	1	6	7
133	R:R:F168	R:R:F169	4.29	Yes	No	1	6	6
134	R:R:F168	R:R:I174	5.02	Yes	No	0	6	8
135	R:R:E171	R:R:S170	10.06	No	No	0	6	3
136	R:R:E171	R:R:Y173	10.1	No	No	0	6	4
137	R:R:F328	R:R:W172	7.02	No	No	0	5	4
138	R:R:I174	R:R:Y173	7.25	No	No	0	8	4
139	R:R:L175	R:R:T323	4.42	No	No	0	7	7
140	R:R:L175	R:R:S327	3	No	No	0	7	6
141	R:R:S179	R:R:S320	3.26	No	No	0	8	8
142	R:R:F180	R:R:V184	3.93	No	No	0	4	7
143	R:R:E182	R:R:W316	10.9	Yes	Yes	1	8	9
144	R:R:E182	W:W:?1	18.3	Yes	Yes	1	8	0
145	R:R:F183	R:R:V187	3.93	No	No	0	9	6
146	R:R:A317	R:R:F183	2.77	No	No	0	7	9
147	R:R:I188	R:R:V184	3.07	No	No	0	4	7
148	R:R:I185	R:R:P186	3.39	No	Yes	0	6	9
149	R:R:I185	R:R:L189	2.85	No	No	0	6	7
150	R:R:F312	R:R:P186	2.89	Yes	Yes	1	9	9
151	R:R:F312	R:R:V187	2.62	Yes	No	0	9	6
152	R:R:N194	R:R:V190	2.96	No	No	0	9	9
153	R:R:L309	R:R:V190	2.98	No	No	0	8	9
154	R:R:F193	R:R:Y192	5.16	Yes	No	0	7	5
155	R:R:N196	R:R:Y192	16.28	No	No	0	6	5
156	R:R:L305	R:R:N194	6.87	No	No	0	8	9
157	R:R:W199	R:R:Y198	23.15	No	No	0	4	7
158	R:R:L301	R:R:Y198	3.52	No	No	0	8	7
159	R:R:W199	R:R:W202	7.5	No	Yes	0	4	6
160	R:R:L201	R:R:L301	11.07	No	No	0	8	8
161	R:R:E294	R:R:W202	3.27	No	Yes	0	5	6
162	R:R:E294	R:R:V293	5.7	No	No	0	5	5
163	R:R:L296	R:R:R300	4.86	No	No	0	4	8
164	R:R:K303	R:R:R299	6.19	No	No	0	7	6
165	R:R:L301	R:R:L305	2.77	No	No	0	8	8
166	R:R:I307	R:R:K303	4.36	No	No	0	7	7
167	R:R:L308	R:R:L357	5.54	No	No	0	8	8
168	R:R:L308	R:R:Y358	3.52	No	Yes	0	8	9
169	R:R:F312	R:R:W316	3.01	Yes	Yes	1	9	9
170	R:R:Q347	R:R:W316	24.09	No	Yes	1	8	9
171	R:R:N350	R:R:W316	7.91	No	Yes	0	9	9
172	R:R:W316	W:W:?1	6.55	Yes	Yes	1	9	0
173	R:R:T323	R:R:Y319	8.74	No	Yes	0	7	7
174	R:R:Y319	R:R:Y340	4.96	Yes	No	0	7	5
175	R:R:A343	R:R:Y319	2.67	No	Yes	0	5	7
176	R:R:F344	R:R:Y319	10.32	No	Yes	1	6	7
177	R:R:Q347	R:R:Y319	3.38	No	Yes	1	8	7
178	R:R:F322	R:R:W339	11.02	No	No	0	6	5
179	R:R:L326	R:R:V325	2.98	No	No	0	5	6
180	R:R:F328	R:R:Y329	11.35	No	No	0	5	5
181	R:R:S330	R:R:Y329	16.53	No	No	0	2	5
182	R:R:G334	R:R:P335	4.06	No	No	0	1	4
183	R:R:K336	R:R:Y340	10.75	No	No	0	4	5
184	R:R:S337	R:R:W339	6.18	No	No	0	2	5
185	R:R:W345	R:R:W348	6.56	No	Yes	0	8	8
186	R:R:F349	R:R:V353	3.93	No	No	0	4	7
187	R:R:N350	R:R:N354	13.62	No	No	0	9	9
188	R:R:L357	R:R:V353	2.98	No	No	0	8	7
189	R:R:H362	R:R:R364	6.77	No	No	0	9	7
190	R:R:A298	R:R:W202	2.59	No	Yes	0	8	6
191	R:R:S115	R:R:Y122	2.54	No	No	0	8	8
192	R:R:I132	R:R:R49	2.51	Yes	No	0	7	7
193	R:R:F53	R:R:I108	2.51	No	No	0	8	9
194	R:R:I197	R:R:R112	2.51	No	No	0	9	9
195	R:R:T99	R:R:Y103	2.5	No	No	0	8	7
196	R:R:V64	R:R:W348	2.45	No	Yes	0	8	8
197	R:R:V338	R:R:W339	2.45	No	No	0	1	5
198	R:R:F369	R:R:L35	2.44	No	No	0	8	8
199	R:R:F144	R:R:L96	2.44	No	No	0	5	6
200	R:R:I197	R:R:Y113	2.42	No	Yes	0	9	9
201	R:R:I69	R:R:W348	2.35	No	Yes	0	8	8
202	R:R:L71	R:R:W90	2.28	No	Yes	0	5	7
203	R:R:F349	R:R:F352	2.14	No	No	0	4	6
204	R:R:G167	R:R:P166	2.03	No	Yes	0	6	7
205	R:R:R341	R:R:W345	2	No	No	0	6	8
206	R:R:W172	R:R:Y173	1.93	No	No	0	4	4
207	R:R:A317	R:R:P318	1.87	No	No	0	7	9
208	R:R:G334	R:R:T333	1.82	No	No	0	1	6
209	R:R:P359	R:R:V36	1.77	No	No	0	8	9
210	R:R:G128	R:R:I132	1.76	No	Yes	0	4	7
211	R:R:G148	R:R:I151	1.76	No	No	0	5	7
212	R:R:S320	W:W:?1	1.73	No	Yes	0	8	0
213	R:R:G32	R:R:L31	1.71	No	No	0	8	4
214	R:R:G310	R:R:L309	1.71	No	No	0	6	8
215	R:R:C315	R:R:V311	1.71	No	No	0	8	6
216	R:R:M150	R:R:P149	1.68	No	No	0	7	8
217	R:R:D159	R:R:G161	1.68	No	No	0	4	1
218	R:R:L346	R:R:P318	1.64	No	No	0	8	9
219	R:R:S50	R:R:S51	1.63	No	Yes	0	8	9
220	R:R:S115	R:R:V116	1.62	No	No	0	8	8
221	R:R:S200	R:R:V116	1.62	No	No	0	6	8
222	R:R:V133	R:R:V137	1.6	No	No	0	3	4
223	R:R:V137	R:R:V141	1.6	No	No	0	4	4
224	R:R:V311	R:R:V353	1.6	No	No	0	6	7
225	R:R:T92	R:R:V88	1.59	No	No	0	6	7
226	R:R:A19	R:R:L77	1.58	No	Yes	0	5	6
227	R:R:A191	R:R:L309	1.58	No	No	0	5	8
228	R:R:A317	R:R:L321	1.58	No	No	0	7	6
229	R:R:I29	R:R:V25	1.54	No	No	0	8	7
230	R:R:I69	R:R:V25	1.54	No	No	0	8	7
231	R:R:I37	R:R:V41	1.54	No	No	0	8	3
232	R:R:I185	R:R:V184	1.54	No	No	0	6	7
233	R:R:I307	R:R:V311	1.54	No	No	0	7	6
234	R:R:I151	R:R:T92	1.52	No	No	0	7	6
235	R:R:L308	R:R:S304	1.5	No	No	0	8	8
236	R:R:L326	R:R:S330	1.5	No	No	0	5	2
237	R:R:L152	R:R:V88	1.49	No	No	0	5	7
238	R:R:N118	R:R:V120	1.48	No	No	0	6	7
239	R:R:L18	R:R:T14	1.47	No	No	0	5	5
240	R:R:I324	R:R:L175	1.43	No	No	0	6	7
241	R:R:L18	R:R:M22	1.41	No	No	0	5	7
242	R:R:L142	R:R:L145	1.38	No	No	0	5	4
243	R:R:L356	R:R:L360	1.38	No	No	0	6	6
244	R:R:E85	R:R:K84	1.35	No	No	0	3	3
245	R:R:L360	R:R:Q366	1.33	No	No	0	6	9
246	R:R:F369	R:R:V36	1.31	No	No	0	8	9
247	R:R:F322	R:R:V325	1.31	No	No	0	6	6
248	R:R:R341	R:R:V338	1.31	No	No	0	6	1
249	R:R:R49	R:R:T127	1.29	No	No	0	7	8
250	R:R:R123	R:R:T124	1.29	No	No	0	5	5
251	R:R:K44	R:R:R47	1.24	No	No	0	7	8
252	R:R:K203	R:R:W202	1.16	No	Yes	0	6	6
253	R:R:R299	R:R:R300	1.07	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.4971	7	1	0
2	R:R:S51	3.89	4	5	9
3	R:R:L57	4.5325	4	4	9
4	R:R:D61	7.046	5	4	9
5	R:R:F62	4.372	5	3	8
6	R:R:L77	6.89	4	2	6
7	R:R:F82	13.8	4	8	6
8	R:R:W90	4.49	4	1	7
9	R:R:L91	5.0625	4	1	6
10	R:R:Y95	9.298	5	1	8
11	R:R:V102	5.76	4	1	8
12	R:R:Y113	5.9525	4	0	9
13	R:R:I132	4.5175	4	6	7
14	R:R:P166	5.24833	6	1	7
15	R:R:F168	5.6275	4	1	6
16	R:R:E182	9.075	4	1	8
17	R:R:P186	3.335	4	1	9
18	R:R:F193	5.5225	4	0	7
19	R:R:W202	3.63	4	0	6
20	R:R:F312	4.0975	4	1	9
21	R:R:W316	8.91857	7	1	9
22	R:R:Y319	5.74667	6	1	7
23	R:R:W348	6.14	7	1	8
24	R:R:Y358	5.5825	4	0	9
25	W:W:?1	7.834	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W348	14.0032	11.79	Yes	Yes	1	0	8
2	R:R:W345	R:R:W348	40.6164	6.56	No	Yes	0	8	8
3	R:R:M22	R:R:W345	28.4611	3.49	No	No	0	7	8
4	R:R:I73	R:R:M22	23.5167	13.12	No	No	0	6	7
5	R:R:Q347	R:R:W316	13.4257	24.09	No	Yes	1	8	9
6	R:R:N350	R:R:W316	100	7.91	No	Yes	0	9	9
7	R:R:N350	R:R:N354	99.9856	13.62	No	No	0	9	9
8	R:R:I105	R:R:N354	83.2178	5.66	No	No	0	9	9
9	R:R:I105	R:R:Y358	84.2067	12.09	No	Yes	0	9	9
10	R:R:L308	R:R:Y358	22.2752	3.52	No	Yes	0	8	9
11	R:R:L308	R:R:L357	19.4529	5.54	No	No	0	8	8
12	R:R:L357	R:R:V353	17.9082	2.98	No	No	0	8	7
13	R:R:W316	W:W:?1	44.2471	6.55	Yes	Yes	1	9	0
14	R:R:I69	R:R:W348	11.2747	2.35	No	Yes	0	8	8
15	R:R:I69	R:R:V25	11.1881	1.54	No	No	0	8	7
16	R:R:I29	R:R:V25	11.5707	1.54	No	No	0	8	7
17	R:R:I29	R:R:S351	12.1409	3.1	No	No	0	8	9
18	R:R:D61	R:R:N354	31.1029	4.04	Yes	No	0	9	9
19	R:R:D61	R:R:N33	18.4135	6.73	Yes	No	0	9	9
20	R:R:F62	R:R:N33	13.8949	4.83	Yes	No	0	8	9
21	R:R:I108	R:R:Y358	43.15	3.63	No	Yes	0	9	9
22	R:R:F54	R:R:I108	32.6693	6.28	No	No	0	8	9
23	R:R:F54	R:R:P359	13.3319	4.33	No	No	0	8	8
24	R:R:P359	R:R:V36	11.715	1.77	No	No	0	8	9
25	R:R:F365	R:R:F54	19.2868	4.29	No	No	0	8	8
26	R:R:F365	R:R:S51	11.3252	5.28	No	Yes	5	8	9
27	R:R:D61	R:R:L57	27.3784	6.79	Yes	Yes	4	9	9
28	R:R:L57	R:R:N104	40.8258	5.49	Yes	No	0	9	8
29	R:R:N104	R:R:N56	35.8308	12.26	No	No	0	8	9
30	R:R:M136	R:R:N56	25.646	7.01	No	No	0	8	9
31	R:R:I132	R:R:M136	20.6872	2.92	Yes	No	6	7	8
32	R:R:I132	R:R:R49	15.4973	2.51	Yes	No	0	7	7
33	R:R:I105	R:R:L57	30.6554	2.85	No	Yes	0	9	9
34	R:R:F53	R:R:I108	11.2314	2.51	No	No	0	8	9
35	R:R:V64	R:R:W348	11.2531	2.45	No	Yes	0	8	8
36	L:L:?1	R:R:Y95	12.7183	13.24	Yes	Yes	1	0	8
37	R:R:P166	R:R:Y95	35.5132	6.95	Yes	Yes	1	7	8
38	R:R:L91	R:R:P166	27.2268	4.93	Yes	Yes	1	6	7
39	R:R:I73	R:R:P74	14.891	3.39	No	No	0	6	5
40	R:R:F82	R:R:P74	13.0793	7.22	Yes	No	0	6	5
41	R:R:I151	R:R:L91	15.1942	7.14	No	Yes	0	7	6
42	R:R:F168	R:R:Y95	14.4868	3.09	Yes	Yes	1	6	8
43	R:R:C98	R:R:W348	36.1917	2.61	No	Yes	0	8	8
44	R:R:V102	R:R:W316	12.408	7.36	Yes	Yes	1	8	9
45	R:R:P186	R:R:V102	13.3319	3.53	Yes	Yes	1	9	8
46	R:R:F312	R:R:W316	21.9215	3.01	Yes	Yes	1	9	9
47	R:R:F312	R:R:P186	11.2098	2.89	Yes	Yes	1	9	9
48	R:R:R112	R:R:Y358	39.411	3.09	No	Yes	0	9	9
49	R:R:I197	R:R:R112	38.22	2.51	No	No	0	9	9
50	R:R:I197	R:R:Y113	37.0218	2.42	No	Yes	0	9	9
51	R:R:F193	R:R:Y113	31.2256	4.13	Yes	Yes	0	7	9
52	R:R:F193	R:R:S109	25.5233	6.61	Yes	No	0	7	9
53	R:R:S109	R:R:V190	24.0797	3.23	No	No	0	9	9
54	R:R:F168	R:R:I174	13.4257	5.02	Yes	No	0	6	8
55	R:R:I174	R:R:Y173	11.8089	7.25	No	No	0	8	4
56	R:R:I185	R:R:P186	17.605	3.39	No	Yes	0	6	9
57	R:R:I185	R:R:V184	10.6034	1.54	No	No	0	6	7
58	R:R:F312	R:R:V187	10.0404	2.62	Yes	No	0	9	6
59	R:R:N194	R:R:V190	17.9226	2.96	No	No	0	9	9
60	R:R:L305	R:R:N194	16.3491	6.87	No	No	0	8	9
61	R:R:L301	R:R:L305	14.7466	2.77	No	No	0	8	8
62	R:R:L301	R:R:Y198	11.6862	3.52	No	No	0	8	7
63	R:R:W199	R:R:Y198	10.0693	23.15	No	No	0	4	7
64	R:R:V311	R:R:V353	11.5274	1.6	No	No	0	6	7
65	R:R:R341	R:R:W345	12.6389	2	No	No	0	6	8
66	R:R:R341	R:R:V338	11.0871	1.31	No	No	0	6	1
67	R:R:C98	R:R:W316	36.9713	2.61	No	Yes	0	8	9
68	R:R:D61	R:R:S351	13.3102	10.31	Yes	No	0	9	9
69	R:R:Y95	W:W:?1	42.2838	8.09	Yes	Yes	1	8	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D94	11.5	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y95	13.24	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y319	4.41	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F344	21.78	1	Yes	No	0	6	0	1
L:L:?1	R:R:Q347	6.26	1	Yes	No	0	8	0	1
L:L:?1	R:R:W348	11.79	1	Yes	Yes	0	8	0	1
L:L:?1	W:W:?1	4.5	1	Yes	Yes	0	0	0	1
R:R:D94	R:R:S68	5.89	1	No	No	8	8	1	2
R:R:S68	R:R:W348	4.94	1	No	Yes	8	8	2	1
R:R:D94	R:R:W348	12.28	1	No	Yes	8	8	1	1
R:R:N147	R:R:Y95	15.12	0	No	Yes	8	8	2	1
R:R:P166	R:R:Y95	6.95	1	Yes	Yes	7	8	2	1
R:R:F168	R:R:Y95	3.09	1	Yes	Yes	6	8	2	1
R:R:Y95	W:W:?1	8.09	1	Yes	Yes	8	0	1	1
R:R:C98	R:R:W316	2.61	0	No	Yes	8	9	2	2
R:R:C98	R:R:W348	2.61	0	No	Yes	8	8	2	1
R:R:F168	R:R:P166	10.11	1	Yes	Yes	6	7	2	2
R:R:E182	R:R:W316	10.9	1	Yes	Yes	8	9	2	2
R:R:E182	W:W:?1	18.3	1	Yes	Yes	8	0	2	1
R:R:Q347	R:R:W316	24.09	1	No	Yes	8	9	1	2
R:R:W316	W:W:?1	6.55	1	Yes	Yes	9	0	2	1
R:R:T323	R:R:Y319	8.74	0	No	Yes	7	7	2	1
R:R:Y319	R:R:Y340	4.96	1	Yes	No	7	5	1	2
R:R:A343	R:R:Y319	2.67	0	No	Yes	5	7	2	1
R:R:F344	R:R:Y319	10.32	1	No	Yes	6	7	1	1
R:R:Q347	R:R:Y319	3.38	1	No	Yes	8	7	1	1
R:R:W345	R:R:W348	6.56	0	No	Yes	8	8	2	1
R:R:V64	R:R:W348	2.45	0	No	Yes	8	8	2	1
R:R:I69	R:R:W348	2.35	0	No	Yes	8	8	2	1
R:R:S320	W:W:?1	1.73	0	No	Yes	8	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JXT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.61
Number of Linked Nodes	238
Number of Links	253
Number of Hubs	25
Number of Links mediated by Hubs	96
Number of Communities	9
Number of Nodes involved in Communities	44
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	28273
Length Of Smallest Path	3
Average Path Length	12.1521
Length of Longest Path	29
Minimum Path Strength	1.355
Average Path Strength	5.97952
Maximum Path Strength	19.98
Minimum Path Correlation	0.7
Average Path Correlation	0.921816
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	53.085
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.5912
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • regulation of intracellular signal transduction • regulation of response to stimulus • MAPK cascade • regulation of cell communication • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	beta-aminoethylglyoxaline
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


Code	PO4
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	PO4
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>8JXT_nogp_Chain_R T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D K N L R H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N A V S Y R T Q H T G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K D E G S E C E P G F F S E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S S A T G P K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F Q K A F L K I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	9JED	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	2.58	2025-09-10	doi.org/10.1038/s41401-025-01633-4
	9JED (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		2.58	2025-09-10	doi.org/10.1038/s41401-025-01633-4
	9L42	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.9	2025-10-22	doi.org/10.3390/ph18030292
	9L42 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.9	2025-10-22	doi.org/10.3390/ph18030292
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	9LRC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	-	2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9LRE	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9LRE (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9JG1	A	Amine	Histamine	H₄	Homo sapiens	Adriforant	-	-	3.62	2025-12-03	10.1038/s41401-025-01633-4
	9JG1 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Adriforant	-		3.62	2025-12-03	10.1038/s41401-025-01633-4

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.