psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S13	R:R:T14	3.2	No	No	0	2	5
2	R:R:F78	R:R:R15	3.21	No	No	0	5	3
3	R:R:L18	R:R:L77	4.15	No	No	0	5	6
4	R:R:I73	R:R:M22	7.29	Yes	No	0	6	7
5	R:R:L77	R:R:M22	5.65	No	No	0	6	7
6	R:R:M22	R:R:W345	8.14	No	Yes	0	7	8
7	R:R:A26	R:R:I69	3.25	No	Yes	0	7	8
8	R:R:F27	R:R:L31	13.4	No	No	0	5	4
9	R:R:G65	R:R:I29	3.53	No	No	0	8	8
10	R:R:F62	R:R:M30	4.98	Yes	No	0	8	6
11	R:R:A58	R:R:N33	3.13	No	Yes	0	9	9
12	R:R:D61	R:R:N33	6.73	Yes	Yes	0	9	9
13	R:R:F62	R:R:N33	6.04	Yes	Yes	0	8	9
14	R:R:N33	R:R:P355	6.52	Yes	No	0	9	9
15	R:R:F369	R:R:V35	3.93	No	No	0	8	8
16	R:R:F373	R:R:V35	3.93	No	No	0	7	8
17	R:R:A58	R:R:V36	3.39	No	No	0	9	9
18	R:R:P359	R:R:V36	5.3	No	No	0	8	9
19	R:R:I37	R:R:L55	4.28	No	No	0	8	7
20	R:R:A58	R:R:I37	3.25	No	No	0	9	8
21	R:R:F40	R:R:Y52	7.22	No	No	0	8	6
22	R:R:F40	R:R:L55	20.7	No	No	0	8	7
23	R:R:I372	R:R:V42	9.22	No	No	0	6	6
24	R:R:D43	R:R:K371	8.3	No	No	0	7	5
25	R:R:K44	R:R:R47	8.66	No	No	0	7	8
26	R:R:L46	R:R:N51	9.61	No	Yes	2	9	9
27	R:R:F365	R:R:L46	9.74	Yes	No	2	8	9
28	R:R:R47	R:R:Y52	4.12	No	No	0	8	6
29	R:R:H48	R:R:R49	4.51	No	No	0	7	7
30	R:R:H48	R:R:Y122	4.36	No	No	0	7	8
31	R:R:Q125	R:R:R49	10.51	No	No	3	5	7
32	R:R:R49	R:R:T127	11.64	No	Yes	3	7	8
33	R:R:N51	R:R:S50	4.47	Yes	No	2	9	8
34	R:R:F54	R:R:S50	3.96	Yes	No	2	8	8
35	R:R:H362	R:R:S50	5.58	Yes	No	2	9	8
36	R:R:H362	R:R:N51	3.83	Yes	Yes	2	9	9
37	R:R:F365	R:R:N51	7.25	Yes	Yes	2	8	9
38	R:R:I132	R:R:Y52	8.46	No	No	0	7	6
39	R:R:F53	R:R:L107	12.18	No	No	0	8	8
40	R:R:D111	R:R:F53	5.97	No	No	0	9	8
41	R:R:F54	R:R:I108	7.54	Yes	No	2	8	9
42	R:R:F54	R:R:Y358	5.16	Yes	Yes	2	8	9
43	R:R:F54	R:R:H362	7.92	Yes	Yes	2	8	9
44	R:R:F365	R:R:F54	3.22	Yes	Yes	2	8	8
45	R:R:I59	R:R:L55	4.28	No	No	0	6	7
46	R:R:N104	R:R:N56	14.98	No	No	0	8	9
47	R:R:M136	R:R:N56	11.22	No	No	0	8	9
48	R:R:N56	R:R:W140	10.17	No	No	0	9	9
49	R:R:D61	R:R:L57	5.43	Yes	No	0	9	9
50	R:R:L57	R:R:N104	4.12	No	No	0	9	8
51	R:R:D61	R:R:S60	4.42	Yes	No	0	9	9
52	R:R:D61	R:R:S351	8.83	Yes	No	0	9	9
53	R:R:D61	R:R:N354	4.04	Yes	No	0	9	9
54	R:R:F62	R:R:V66	5.24	Yes	No	0	8	5
55	R:R:F63	R:R:L97	3.65	No	No	0	6	6
56	R:R:S68	R:R:V64	3.23	No	No	0	8	8
57	R:R:L97	R:R:V64	5.96	No	No	0	6	8
58	R:R:S351	R:R:V64	4.85	No	No	0	9	8
59	R:R:I67	R:R:V66	4.61	No	No	0	6	5
60	R:R:I67	R:R:T93	4.56	No	No	0	6	5
61	R:R:D94	R:R:S68	7.36	No	No	1	8	8
62	R:R:S68	R:R:W348	6.18	No	Yes	1	8	8
63	R:R:I69	R:R:P70	3.39	Yes	No	0	8	9
64	R:R:I69	R:R:W345	5.87	Yes	Yes	1	8	8
65	R:R:I69	R:R:W348	3.52	Yes	Yes	1	8	8
66	R:R:T76	R:R:Y72	9.99	No	Yes	0	5	7
67	R:R:W90	R:R:Y72	10.61	No	Yes	0	7	7
68	R:R:F344	R:R:Y72	12.38	Yes	Yes	1	6	7
69	R:R:W345	R:R:Y72	4.82	Yes	Yes	1	8	7
70	R:R:W348	R:R:Y72	5.79	Yes	Yes	1	8	7
71	R:R:I73	R:R:P74	3.39	Yes	No	0	6	5
72	R:R:D81	R:R:P74	9.66	No	No	0	3	5
73	R:R:H75	R:R:T76	4.11	Yes	No	0	6	5
74	R:R:H75	R:R:W80	9.52	Yes	No	0	6	9
75	R:R:D81	R:R:H75	3.78	No	Yes	4	3	6
76	R:R:F82	R:R:H75	12.44	Yes	Yes	4	6	6
77	R:R:C164	R:R:H75	4.42	No	Yes	0	9	6
78	R:R:F78	R:R:L77	8.53	No	No	0	5	6
79	R:R:E79	R:R:W80	3.27	No	No	0	3	9
80	R:R:D81	R:R:F82	15.52	No	Yes	4	3	6
81	R:R:F82	R:R:I86	3.77	Yes	No	0	6	5
82	R:R:C87	R:R:L91	3.17	No	No	0	9	6
83	R:R:C164	R:R:C87	7.28	No	No	0	9	9
84	R:R:E155	R:R:V88	8.56	No	No	0	6	7
85	R:R:L91	R:R:W90	4.56	No	No	0	6	7
86	R:R:D94	R:R:W348	12.28	No	Yes	1	8	8
87	L:L:?1	R:R:D94	8.94	Yes	No	1	0	8
88	R:R:N147	R:R:Y95	15.12	Yes	Yes	1	8	8
89	R:R:I151	R:R:Y95	4.84	Yes	Yes	1	7	8
90	R:R:P166	R:R:Y95	6.95	Yes	Yes	1	7	8
91	L:L:?1	R:R:Y95	13.24	Yes	Yes	1	0	8
92	R:R:L96	R:R:W140	6.83	No	No	0	6	9
93	L:L:?1	R:R:C98	7.47	Yes	No	0	0	8
94	R:R:T99	R:R:Y103	8.74	No	No	0	8	7
95	R:R:A143	R:R:T99	3.36	No	No	0	8	8
96	R:R:A100	R:R:W140	7.78	No	No	0	8	9
97	R:R:P186	R:R:V102	3.53	No	No	0	9	8
98	R:R:F312	R:R:V102	7.87	No	No	5	9	8
99	R:R:V102	R:R:W316	6.13	No	Yes	5	8	9
100	R:R:V146	R:R:Y103	3.79	No	No	0	7	7
101	R:R:N104	R:R:V139	4.43	No	No	0	8	8
102	R:R:I105	R:R:N354	5.66	No	No	0	9	9
103	R:R:I105	R:R:Y358	4.84	No	Yes	0	9	9
104	R:R:I108	R:R:Y358	3.63	No	Yes	2	9	9
105	R:R:S109	R:R:V190	4.85	No	No	0	9	9
106	R:R:Y110	R:R:Y113	3.97	No	No	6	6	9
107	R:R:Q114	R:R:Y110	12.4	No	No	0	5	6
108	R:R:F193	R:R:Y110	9.28	Yes	No	6	7	6
109	R:R:D111	R:R:Y122	10.34	No	No	0	9	8
110	R:R:R112	R:R:Y358	8.23	No	Yes	0	9	9
111	R:R:F193	R:R:Y113	10.32	Yes	No	6	7	9
112	R:R:Y113	R:R:Y196	9.93	No	No	0	9	6
113	R:R:S115	R:R:Y122	8.9	No	No	0	8	8
114	R:R:I197	R:R:V116	10.75	No	No	0	9	8
115	R:R:S200	R:R:V116	3.23	No	No	0	6	8
116	R:R:S117	R:R:Y196	6.36	No	No	0	7	6
117	R:R:N118	R:R:S121	4.47	No	No	0	6	5
118	R:R:Q125	R:R:T127	4.25	No	Yes	3	5	8
119	R:R:G128	R:R:T127	3.64	No	Yes	0	4	8
120	R:R:K131	R:R:T127	4.5	No	Yes	0	7	8
121	R:R:F144	R:R:G148	4.52	No	Yes	1	5	5
122	R:R:F144	R:R:P149	4.33	No	No	1	5	8
123	R:R:N147	R:R:V146	4.43	Yes	No	0	8	7
124	R:R:I151	R:R:N147	4.25	Yes	Yes	1	7	8
125	R:R:N147	R:R:T178	4.39	Yes	No	0	8	8
126	R:R:G148	R:R:P149	4.06	Yes	No	1	5	8
127	R:R:F168	R:R:M150	7.46	Yes	No	0	6	7
128	R:R:I174	R:R:M150	7.29	No	No	0	8	7
129	R:R:I151	R:R:P166	3.39	Yes	Yes	1	7	7
130	R:R:S154	R:R:W157	12.36	No	No	0	8	6
131	R:R:G167	R:R:S154	3.71	No	No	0	6	8
132	R:R:F168	R:R:S154	3.96	Yes	No	0	6	8
133	R:R:E155	R:R:K158	9.45	No	No	0	6	6
134	R:R:K158	R:R:S162	9.18	No	No	0	6	3
135	R:R:E160	R:R:G161	3.27	No	No	0	3	1
136	R:R:E163	R:R:K336	10.8	No	Yes	0	4	4
137	R:R:E165	R:R:F169	10.49	No	Yes	0	4	6
138	R:R:E165	R:R:K336	6.75	No	Yes	0	4	4
139	R:R:F168	R:R:P166	10.11	Yes	Yes	1	6	7
140	R:R:F169	R:R:P166	13	Yes	Yes	1	6	7
141	R:R:F168	R:R:F169	4.29	Yes	Yes	1	6	6
142	R:R:F169	R:R:L175	3.65	Yes	Yes	1	6	7
143	R:R:F169	R:R:T323	6.49	Yes	No	1	6	7
144	R:R:E171	R:R:Y173	10.1	No	No	0	6	4
145	R:R:W172	R:R:Y173	13.5	No	No	0	4	4
146	R:R:F328	R:R:W172	6.01	No	No	0	5	4
147	R:R:I174	R:R:Y173	7.25	No	No	0	8	4
148	R:R:L175	R:R:T323	7.37	Yes	No	1	7	7
149	R:R:I324	R:R:S179	4.64	No	No	0	6	8
150	R:R:F180	R:R:L181	6.09	No	No	0	4	5
151	R:R:F180	R:R:L184	6.09	No	No	0	4	7
152	R:R:F180	R:R:V185	5.24	No	No	0	4	6
153	R:R:E182	R:R:W316	8.72	No	Yes	0	8	9
154	R:R:F183	R:R:V187	9.18	No	No	0	9	6
155	R:R:P186	R:R:V185	3.53	No	No	0	9	6
156	R:R:F193	R:R:L189	3.65	Yes	No	0	7	7
157	R:R:A191	R:R:L309	3.15	No	No	0	5	8
158	R:R:F193	R:R:Y192	5.16	Yes	No	0	7	5
159	R:R:L305	R:R:N194	5.49	Yes	No	0	8	9
160	R:R:W199	R:R:W202	7.5	No	No	0	4	6
161	R:R:R204	R:R:S200	7.91	No	No	0	8	6
162	R:R:L201	R:R:L301	4.15	No	No	0	8	8
163	R:R:E294	R:R:G205	4.91	No	No	8	5	5
164	R:R:G205	R:R:R297	4.5	No	No	8	5	7
165	R:R:H292	R:R:L295	3.86	No	No	0	5	4
166	R:R:E294	R:R:R297	8.14	No	No	8	5	7
167	R:R:L296	R:R:R299	7.29	No	No	0	4	6
168	R:R:L301	R:R:L305	5.54	No	Yes	7	8	8
169	R:R:L308	R:R:L357	4.15	No	No	0	8	8
170	R:R:L308	R:R:Y358	4.69	No	Yes	0	8	9
171	R:R:L357	R:R:V311	4.47	No	No	0	8	6
172	R:R:F312	R:R:W316	8.02	No	Yes	5	9	9
173	R:R:C315	R:R:N350	6.3	No	No	0	8	9
174	R:R:Q347	R:R:W316	12.05	Yes	Yes	0	8	9
175	R:R:N350	R:R:W316	6.78	No	Yes	0	9	9
176	R:R:L346	R:R:P318	3.28	No	No	0	8	9
177	R:R:Y319	R:R:Y340	6.95	No	Yes	0	7	5
178	R:R:F344	R:R:Y319	10.32	Yes	No	0	6	7
179	R:R:Q347	R:R:Y319	11.27	Yes	No	0	8	7
180	R:R:F322	R:R:Y340	4.13	No	Yes	0	6	5
181	R:R:L326	R:R:R334	4.86	No	Yes	0	5	1
182	R:R:L326	R:R:Y340	3.52	No	Yes	0	5	5
183	R:R:R334	R:R:Y329	5.14	Yes	No	0	1	5
184	R:R:P335	R:R:R334	4.32	No	Yes	0	4	1
185	R:R:K336	R:R:Y340	9.55	Yes	Yes	0	4	5
186	R:R:K336	R:R:R341	3.71	Yes	No	0	4	6
187	R:R:F344	R:R:W348	8.02	Yes	Yes	1	6	8
188	L:L:?1	R:R:F344	17.19	Yes	Yes	1	0	6
189	R:R:W345	R:R:W348	13.12	Yes	Yes	1	8	8
190	L:L:?1	R:R:Q347	16.28	Yes	Yes	0	0	8
191	L:L:?1	R:R:W348	11.79	Yes	Yes	1	0	8
192	R:R:F349	R:R:F352	6.43	No	No	0	4	6
193	R:R:F349	R:R:V353	3.93	No	No	0	4	7
194	R:R:N350	R:R:N354	10.9	No	No	0	9	9
195	R:R:F352	R:R:F356	3.22	No	No	0	6	6
196	R:R:H362	R:R:R364	4.51	Yes	No	0	9	7
197	R:R:F365	R:R:H362	3.39	Yes	Yes	2	8	9
198	R:R:F365	R:R:F369	4.29	Yes	No	2	8	8
199	R:R:F373	R:R:I372	3.77	No	No	0	7	6
200	R:R:A368	R:R:D43	3.09	No	No	0	8	7
201	R:R:I132	R:R:T127	3.04	No	Yes	0	7	8
202	R:R:F183	R:R:W316	3.01	No	Yes	0	9	9
203	R:R:L175	R:R:S179	3	Yes	No	0	7	8
204	R:R:L175	R:R:S327	3	Yes	No	0	7	6
205	R:R:L38	R:R:V42	2.98	No	No	0	4	6
206	R:R:N118	R:R:S117	2.98	No	No	0	6	7
207	R:R:L189	R:R:V185	2.98	No	No	0	7	6
208	R:R:L309	R:R:V190	2.98	No	No	0	8	9
209	R:R:L357	R:R:V353	2.98	No	No	0	8	7
210	R:R:N194	R:R:V190	2.96	No	No	0	9	9
211	R:R:D61	R:R:S101	2.94	Yes	No	0	9	9
212	R:R:D43	R:R:V42	2.92	No	No	0	7	6
213	R:R:I307	R:R:K303	2.91	No	No	0	7	7
214	R:R:W202	R:R:Y198	2.89	No	Yes	0	6	7
215	R:R:F322	R:R:P318	2.89	No	No	0	6	9
216	R:R:I29	R:R:L25	2.85	No	No	0	8	7
217	R:R:I197	R:R:L305	2.85	No	Yes	0	9	8
218	R:R:I29	R:R:N33	2.83	No	Yes	0	8	9
219	R:R:E165	R:R:T333	2.82	No	No	0	4	6
220	R:R:P330	R:R:Y329	2.78	No	No	0	2	5
221	R:R:A28	R:R:F352	2.77	No	No	0	4	6
222	R:R:A39	R:R:F365	2.77	No	Yes	2	8	8
223	R:R:A39	R:R:F369	2.77	No	No	2	8	8
224	R:R:A317	R:R:F183	2.77	No	No	0	7	9
225	R:R:A343	R:R:F322	2.77	No	No	0	5	6
226	R:R:E155	R:R:I151	2.73	No	Yes	0	6	7
227	R:R:K363	R:R:Q366	2.71	No	No	0	5	9
228	R:R:E85	R:R:K84	2.7	No	No	0	3	3
229	R:R:E294	R:R:L295	2.65	No	No	0	5	4
230	R:R:F193	R:R:S109	2.64	Yes	No	0	7	9
231	R:R:R334	R:R:S337	2.64	Yes	No	0	1	2
232	R:R:F89	R:R:T93	2.59	No	No	0	4	5
233	R:R:S156	R:R:W157	2.47	No	No	0	5	6
234	R:R:S337	R:R:W339	2.47	No	No	0	2	5
235	R:R:F82	R:R:L71	2.44	Yes	No	0	6	5
236	R:R:F144	R:R:L145	2.44	No	No	0	5	4
237	R:R:L142	R:R:Y103	2.34	No	No	0	5	7
238	R:R:G148	R:R:T92	1.82	Yes	No	0	5	6
239	R:R:P186	R:R:V106	1.77	No	No	0	9	7
240	R:R:G32	R:R:L31	1.71	No	No	0	8	4
241	R:R:G310	R:R:L309	1.71	No	No	0	6	8
242	R:R:G148	R:R:N147	1.7	Yes	Yes	1	5	8
243	R:R:A19	R:R:I73	1.62	No	Yes	0	5	6
244	R:R:V133	R:R:V137	1.6	No	No	0	3	4
245	R:R:V137	R:R:V141	1.6	No	No	0	4	4
246	R:R:C361	R:R:L360	1.59	No	No	0	7	6
247	R:R:I16	R:R:S13	1.55	No	No	0	5	2
248	R:R:I73	R:R:S23	1.55	Yes	No	0	6	5
249	R:R:I37	R:R:V41	1.54	No	No	0	8	3
250	R:R:I129	R:R:V133	1.54	No	No	0	4	3
251	R:R:I188	R:R:V187	1.54	No	No	0	4	6
252	R:R:I307	R:R:V311	1.54	No	No	0	7	6
253	R:R:I342	R:R:V338	1.54	No	No	0	5	1
254	R:R:K300	R:R:S304	1.53	No	No	0	8	8
255	R:R:M136	R:R:V133	1.52	No	No	0	8	3
256	R:R:F82	R:R:G83	1.51	Yes	No	0	6	7
257	R:R:G205	R:R:R204	1.5	No	No	0	5	8
258	R:R:L152	R:R:V88	1.49	No	No	0	5	7
259	R:R:D159	R:R:S162	1.47	No	No	0	4	3
260	R:R:Q347	R:R:S320	1.44	Yes	No	0	8	8
261	R:R:K363	R:R:K367	1.44	No	No	0	5	5
262	R:R:I177	R:R:L181	1.43	No	No	0	5	5
263	R:R:L31	R:R:M30	1.41	No	No	0	4	6
264	R:R:K131	R:R:L135	1.41	No	No	0	7	7
265	R:R:A34	R:R:F62	1.39	No	Yes	0	4	8
266	R:R:E85	R:R:I86	1.37	No	No	0	3	5
267	R:R:A298	R:R:Y198	1.33	No	Yes	0	8	7
268	R:R:A302	R:R:Y198	1.33	No	Yes	0	7	7
269	R:R:L360	R:R:Q366	1.33	No	No	0	6	9
270	R:R:R123	R:R:T124	1.29	No	No	0	5	5
271	R:R:N45	R:R:R364	1.21	No	No	0	6	7
272	R:R:L301	R:R:Y198	1.17	No	Yes	7	8	7
273	R:R:L305	R:R:Y198	1.17	Yes	Yes	7	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N33	5.05	5	0	9
2	R:R:N51	6.29	4	2	9
3	R:R:F54	5.56	5	2	8
4	R:R:D61	5.39833	6	0	9
5	R:R:F62	4.4125	4	0	8
6	R:R:I69	4.0075	4	1	8
7	R:R:Y72	8.718	5	1	7
8	R:R:I73	3.4625	4	0	6
9	R:R:H75	6.854	5	4	6
10	R:R:F82	7.136	5	4	6
11	R:R:Y95	10.0375	4	1	8
12	R:R:T127	5.414	5	3	8
13	R:R:N147	5.978	5	1	8
14	R:R:G148	3.025	4	1	5
15	R:R:I151	3.8025	4	1	7
16	R:R:P166	8.3625	4	1	7
17	R:R:F168	6.455	4	1	6
18	R:R:F169	7.584	5	1	6
19	R:R:L175	4.255	4	1	7
20	R:R:F193	6.21	5	6	7
21	R:R:Y198	1.578	5	7	7
22	R:R:L305	3.7625	4	7	8
23	R:R:W316	7.45167	6	5	9
24	R:R:R334	4.24	4	0	1
25	R:R:K336	7.7025	4	0	4
26	R:R:Y340	6.0375	4	0	5
27	R:R:F344	11.9775	4	1	6
28	R:R:W345	7.9875	4	1	8
29	R:R:Q347	10.26	4	0	8
30	R:R:W348	8.67143	7	1	8
31	R:R:Y358	5.31	5	2	9
32	R:R:H362	5.046	5	2	9
33	R:R:F365	5.11	6	2	8
34	L:L:?1	12.485	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M22	R:R:W345	16.9029	8.14	No	Yes	0	7	8
2	R:R:F62	R:R:N33	22.0119	6.04	Yes	Yes	0	8	9
3	R:R:D61	R:R:N33	76.7216	6.73	Yes	Yes	0	9	9
4	R:R:D61	R:R:S351	55.3789	8.83	Yes	No	0	9	9
5	R:R:S351	R:R:V64	55.3861	4.85	No	No	0	9	8
6	R:R:S68	R:R:V64	57.4369	3.23	No	No	0	8	8
7	R:R:S68	R:R:W348	39.2387	6.18	No	Yes	1	8	8
8	R:R:W345	R:R:W348	16.8238	13.12	Yes	Yes	1	8	8
9	R:R:A58	R:R:N33	49.4135	3.13	No	Yes	0	9	9
10	R:R:F365	R:R:F369	18.1694	4.29	Yes	No	2	8	8
11	R:R:F365	R:R:F54	25.4659	3.22	Yes	Yes	2	8	8
12	R:R:F54	R:R:Y358	39.2747	5.16	Yes	Yes	2	8	9
13	R:R:I105	R:R:Y358	62.035	4.84	No	Yes	0	9	9
14	R:R:I105	R:R:N354	63.7116	5.66	No	No	0	9	9
15	R:R:D61	R:R:N354	66.115	4.04	Yes	No	0	9	9
16	R:R:N350	R:R:N354	86.695	10.9	No	No	0	9	9
17	R:R:N350	R:R:W316	87.8607	6.78	No	Yes	0	9	9
18	R:R:Q347	R:R:W316	100	12.05	Yes	Yes	0	8	9
19	L:L:?1	R:R:Q347	73.8936	16.28	Yes	Yes	0	0	8
20	L:L:?1	R:R:W348	44.8298	11.79	Yes	Yes	1	0	8
21	R:R:F369	R:R:V35	16.1905	3.93	No	No	0	8	8
22	R:R:F373	R:R:V35	14.4348	3.93	No	No	0	7	8
23	R:R:A58	R:R:I37	43.5634	3.25	No	No	0	9	8
24	R:R:I37	R:R:L55	39.5913	4.28	No	No	0	8	7
25	R:R:F40	R:R:L55	35.5544	20.7	No	No	0	8	7
26	R:R:F40	R:R:Y52	33.4892	7.22	No	No	0	8	6
27	R:R:F373	R:R:I372	12.3768	3.77	No	No	0	7	6
28	R:R:I372	R:R:V42	10.2972	9.22	No	No	0	6	6
29	R:R:I132	R:R:Y52	27.2865	8.46	No	No	0	7	6
30	R:R:I132	R:R:T127	25.4587	3.04	No	Yes	0	7	8
31	R:R:R49	R:R:T127	14.9817	11.64	No	Yes	3	7	8
32	R:R:H48	R:R:R49	12.8517	4.51	No	No	0	7	7
33	R:R:H48	R:R:Y122	10.6426	4.36	No	No	0	7	8
34	R:R:D61	R:R:L57	26.2431	5.43	Yes	No	0	9	9
35	R:R:L57	R:R:N104	24.1347	4.12	No	No	0	9	8
36	R:R:N104	R:R:N56	19.8748	14.98	No	No	0	8	9
37	R:R:M136	R:R:N56	11.1823	11.22	No	No	0	8	9
38	R:R:T76	R:R:Y72	39.9655	9.99	No	Yes	0	5	7
39	R:R:F344	R:R:Y72	27.416	12.38	Yes	Yes	1	6	7
40	R:R:H75	R:R:T76	36.6698	4.11	Yes	No	0	6	5
41	R:R:F82	R:R:I86	10.4627	3.77	Yes	No	0	6	5
42	R:R:E155	R:R:I151	16.2409	2.73	No	Yes	0	6	7
43	R:R:I151	R:R:Y95	16.3201	4.84	Yes	Yes	1	7	8
44	L:L:?1	R:R:Y95	87.357	13.24	Yes	Yes	1	0	8
45	R:R:N147	R:R:Y95	30.6829	15.12	Yes	Yes	1	8	8
46	R:R:P166	R:R:Y95	42.153	6.95	Yes	Yes	1	7	8
47	R:R:N147	R:R:V146	14.2045	4.43	Yes	No	0	8	7
48	R:R:V146	R:R:Y103	11.3838	3.79	No	No	0	7	7
49	R:R:V102	R:R:W316	66.849	6.13	No	Yes	5	8	9
50	R:R:P186	R:R:V102	65.7408	3.53	No	No	0	9	8
51	R:R:P186	R:R:V185	62.8913	3.53	No	No	0	9	6
52	R:R:L189	R:R:V185	55.5156	2.98	No	No	0	7	6
53	R:R:F193	R:R:L189	53.9973	3.65	Yes	No	0	7	7
54	R:R:F193	R:R:S109	39.8503	2.64	Yes	No	0	7	9
55	R:R:S109	R:R:V190	38.1881	4.85	No	No	0	9	9
56	R:R:N194	R:R:V190	31.3953	2.96	No	No	0	9	9
57	R:R:L305	R:R:N194	29.6611	5.49	Yes	No	0	8	9
58	R:R:I197	R:R:L305	16.3057	2.85	No	Yes	0	9	8
59	R:R:I197	R:R:V116	14.6866	10.75	No	No	0	9	8
60	R:R:S200	R:R:V116	13.046	3.23	No	No	0	6	8
61	R:R:G148	R:R:N147	14.2405	1.7	Yes	Yes	1	5	8
62	R:R:F168	R:R:P166	26.9411	10.11	Yes	Yes	1	6	7
63	R:R:F168	R:R:M150	15.7948	7.46	Yes	No	0	6	7
64	R:R:I174	R:R:M150	13.4418	7.29	No	No	0	8	7
65	R:R:F168	R:R:S154	10.7865	3.96	Yes	No	0	6	8
66	R:R:Y319	R:R:Y340	26.7756	6.95	No	Yes	0	7	5
67	R:R:F344	R:R:Y319	18.5795	10.32	Yes	No	0	6	7
68	R:R:F169	R:R:P166	16.9749	13	Yes	Yes	1	6	7
69	R:R:F169	R:R:L175	10.7002	3.65	Yes	Yes	1	6	7
70	R:R:I174	R:R:Y173	10.7865	7.25	No	No	0	8	4
71	R:R:R204	R:R:S200	11.1607	7.91	No	No	0	8	6
72	R:R:L308	R:R:Y358	20.508	4.69	No	Yes	0	8	9
73	R:R:L308	R:R:L357	18.5148	4.15	No	No	0	8	8
74	R:R:L326	R:R:Y340	13.3914	3.52	No	Yes	0	5	5
75	R:R:L326	R:R:R334	11.7363	4.86	No	Yes	0	5	1
76	R:R:L357	R:R:V353	10.6066	2.98	No	No	0	8	7
77	R:R:F82	R:R:H75	20.3713	12.44	Yes	Yes	4	6	6
78	R:R:W348	R:R:Y72	25.4012	5.79	Yes	Yes	1	8	7
79	R:R:D94	R:R:S68	19.0473	7.36	No	No	1	8	8
80	L:L:?1	R:R:D94	19.5366	8.94	Yes	No	1	0	8
81	R:R:Q347	R:R:Y319	30.4454	11.27	Yes	No	0	8	7
82	L:L:?1	R:R:F344	17.3635	17.19	Yes	Yes	1	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D94	R:R:S68	7.36	1	No	No	8	8	1	2
R:R:S68	R:R:W348	6.18	1	No	Yes	8	8	2	1
R:R:I69	R:R:W345	5.87	1	Yes	Yes	8	8	2	2
R:R:I69	R:R:W348	3.52	1	Yes	Yes	8	8	2	1
R:R:F344	R:R:Y72	12.38	1	Yes	Yes	6	7	1	2
R:R:W345	R:R:Y72	4.82	1	Yes	Yes	8	7	2	2
R:R:W348	R:R:Y72	5.79	1	Yes	Yes	8	7	1	2
R:R:D94	R:R:W348	12.28	1	No	Yes	8	8	1	1
L:L:?1	R:R:D94	8.94	1	Yes	No	0	8	0	1
R:R:N147	R:R:Y95	15.12	1	Yes	Yes	8	8	2	1
R:R:I151	R:R:Y95	4.84	1	Yes	Yes	7	8	2	1
R:R:P166	R:R:Y95	6.95	1	Yes	Yes	7	8	2	1
L:L:?1	R:R:Y95	13.24	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:C98	7.47	1	Yes	No	0	8	0	1
R:R:I151	R:R:N147	4.25	1	Yes	Yes	7	8	2	2
R:R:I151	R:R:P166	3.39	1	Yes	Yes	7	7	2	2
R:R:Q347	R:R:W316	12.05	0	Yes	Yes	8	9	1	2
R:R:F344	R:R:Y319	10.32	1	Yes	No	6	7	1	2
R:R:Q347	R:R:Y319	11.27	0	Yes	No	8	7	1	2
R:R:F344	R:R:W348	8.02	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:F344	17.19	1	Yes	Yes	0	6	0	1
R:R:W345	R:R:W348	13.12	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:Q347	16.28	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W348	11.79	1	Yes	Yes	0	8	0	1
R:R:Q347	R:R:S320	1.44	0	Yes	No	8	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HN8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.13
Number of Linked Nodes	252
Number of Links	273
Number of Hubs	34
Number of Links mediated by Hubs	126
Number of Communities	8
Number of Nodes involved in Communities	47
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	37206
Length Of Smallest Path	3
Average Path Length	13.1571
Length of Longest Path	35
Minimum Path Strength	1.46
Average Path Strength	6.91557
Maximum Path Strength	16.735
Minimum Path Correlation	0.7
Average Path Correlation	0.924956
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	51.3835
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7828
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • regulation of intracellular signal transduction • regulation of response to stimulus • MAPK cascade • regulation of cell communication • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	1H-Imidazole-4-ethanamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>8HN8_nogp_Chain_R S T R I T L A F L M S L L A F A I M L G N A V V I L A F V V D K N L R H R S N Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y Q S V S N A V S Y R T Q H T G I L K I V T L M V A V W V L A F L V N G P M I L V S E S W K D E G S E C E P G F F S E W Y I L A I T S F L E F L V P V I L V A Y F N M Y I Y W S L W K R G H L E L L R A R K L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y P S A T R P K S V W Y R I A F W L Q W F N S F V N P F L Y P L C H K R F Q K A F L K I F C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	9LRC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	-	2.84	2025-06-11	To be published
	9LRE	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.84	2025-06-11	To be published
	9LRE (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.84	2025-06-11	To be published
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3

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