psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F27	4.62	Yes	No	0	0	5
2	L:L:?1	R:R:F88	4.62	Yes	Yes	1	0	7
3	L:L:?1	R:R:M118	6.44	Yes	No	0	0	7
4	L:L:?1	R:R:G122	3.9	Yes	No	1	0	7
5	L:L:?1	R:R:E204	3.02	Yes	No	0	0	5
6	L:L:?1	R:R:D208	7.21	Yes	Yes	1	0	5
7	L:L:?1	R:R:F211	5.55	Yes	Yes	1	0	5
8	L:L:?1	R:R:W277	5.19	Yes	Yes	0	0	9
9	L:L:?1	R:R:I284	4.34	Yes	No	1	0	5
10	L:L:?1	R:R:I287	6.5	Yes	No	0	0	5
11	R:R:Q182	R:R:T23	4.25	No	No	0	2	8
12	R:R:Q182	R:R:R24	3.5	No	No	0	2	5
13	R:R:I197	R:R:R24	10.02	No	No	0	4	5
14	R:R:F25	R:R:P26	7.22	Yes	No	0	5	5
15	R:R:F25	R:R:I287	6.28	Yes	No	0	5	5
16	R:R:F25	R:R:I298	7.54	Yes	No	0	5	3
17	R:R:F25	R:R:F303	3.22	Yes	No	0	5	4
18	R:R:F27	R:R:F303	6.43	No	No	0	5	4
19	R:R:F28	R:R:V95	9.18	Yes	No	0	8	6
20	R:R:F115	R:R:F28	4.29	No	Yes	0	5	8
21	R:R:F28	R:R:F304	3.22	Yes	Yes	0	8	4
22	R:R:F28	R:R:V307	5.24	Yes	No	0	8	5
23	R:R:I193	R:R:S29	4.64	No	No	0	4	9
24	R:R:D30	R:R:P300	11.27	No	No	0	6	4
25	R:R:L184	R:R:V31	7.45	Yes	No	0	2	6
26	R:R:K32	R:R:L39	7.05	No	No	0	3	4
27	R:R:D34	R:R:H35	15.13	No	No	0	3	3
28	R:R:L37	R:R:R36	6.07	No	No	0	3	4
29	R:R:E102	R:R:R36	13.96	No	No	0	4	4
30	R:R:A40	R:R:W100	3.89	No	Yes	0	5	5
31	R:R:E43	R:R:R99	13.96	No	No	4	5	4
32	R:R:E43	R:R:F304	15.16	No	Yes	4	5	4
33	R:R:L96	R:R:T44	8.84	No	No	5	6	6
34	R:R:T44	R:R:W100	7.28	No	Yes	5	6	5
35	R:R:L49	R:R:T45	2.95	No	No	0	4	4
36	R:R:F304	R:R:L47	4.87	Yes	No	0	4	6
37	R:R:F51	R:R:I92	7.54	No	No	0	6	7
38	R:R:A315	R:R:V53	3.39	No	No	0	6	5
39	R:R:I89	R:R:S54	6.19	No	Yes	6	6	8
40	R:R:S314	R:R:S54	6.52	No	Yes	6	9	8
41	R:R:A315	R:R:S54	3.42	No	Yes	0	6	8
42	R:R:G57	R:R:L56	3.42	No	No	0	9	4
43	R:R:D85	R:R:N58	8.08	Yes	No	0	9	9
44	R:R:L86	R:R:N58	4.12	No	No	0	7	9
45	R:R:N58	R:R:P318	8.15	No	No	0	9	9
46	R:R:A61	R:R:F82	6.93	No	Yes	0	8	9
47	R:R:F82	R:R:L62	4.87	Yes	No	0	9	6
48	R:R:L79	R:R:V65	2.98	No	No	0	5	7
49	R:R:R68	R:R:R71	3.2	No	Yes	0	6	7
50	R:R:A73	R:R:E135	4.53	No	No	0	6	8
51	R:R:A73	R:R:R155	8.3	No	No	0	6	6
52	R:R:E135	R:R:T74	9.88	No	No	0	8	8
53	R:R:C76	R:R:L79	3.17	No	No	0	5	5
54	R:R:C76	R:R:R155	4.18	No	No	0	5	6
55	R:R:L77	R:R:V132	2.98	No	No	0	7	8
56	R:R:E135	R:R:L77	5.3	No	No	0	8	7
57	R:R:F82	R:R:V78	7.87	Yes	No	0	9	8
58	R:R:N80	R:R:T128	7.31	No	No	0	9	8
59	R:R:L159	R:R:N80	5.49	No	No	0	7	9
60	R:R:N80	R:R:W163	6.78	No	No	0	9	9
61	R:R:F82	R:R:L81	3.65	Yes	Yes	0	9	9
62	R:R:L81	R:R:T128	5.9	Yes	No	0	9	8
63	R:R:L129	R:R:L81	5.54	No	Yes	0	8	9
64	R:R:L81	R:R:N317	4.12	Yes	No	0	9	9
65	R:R:A84	R:R:V124	3.39	No	Yes	0	8	7
66	R:R:D85	R:R:T125	2.89	Yes	No	0	9	9
67	R:R:D85	R:R:S314	4.42	Yes	No	0	9	9
68	R:R:D85	R:R:N317	6.73	Yes	No	0	9	9
69	R:R:L87	R:R:S121	6.01	No	No	0	6	8
70	R:R:F88	R:R:S121	7.93	Yes	No	0	7	8
71	R:R:F88	R:R:G122	3.01	Yes	No	1	7	7
72	R:R:F311	R:R:F88	8.57	No	Yes	0	7	7
73	R:R:I89	R:R:I92	4.42	No	No	0	6	7
74	R:R:I89	R:R:S314	7.74	No	No	6	6	9
75	R:R:A91	R:R:M118	3.22	No	No	0	6	7
76	R:R:L106	R:R:L94	4.15	Yes	No	0	6	5
77	R:R:L114	R:R:L94	5.54	No	No	0	6	5
78	R:R:L96	R:R:W100	5.69	No	Yes	5	6	5
79	R:R:V98	R:R:W104	7.36	No	Yes	0	5	9
80	R:R:L106	R:R:V98	2.98	Yes	No	0	6	5
81	R:R:F304	R:R:R99	13.9	Yes	No	4	4	4
82	R:R:A103	R:R:L105	3.15	No	No	0	5	4
83	R:R:C111	R:R:W104	7.84	No	Yes	2	9	9
84	R:R:V179	R:R:W104	4.9	No	Yes	2	5	9
85	R:R:C194	R:R:W104	16.98	No	Yes	2	9	9
86	R:R:A110	R:R:L106	3.15	No	Yes	0	5	6
87	R:R:G107	R:R:P108	4.06	No	No	0	8	3
88	R:R:H112	R:R:P108	4.58	No	No	0	7	3
89	R:R:L113	R:R:V109	2.98	No	No	0	5	2
90	R:R:C111	R:R:V179	3.42	No	No	2	9	5
91	R:R:C111	R:R:C194	7.28	No	No	2	9	9
92	R:R:F115	R:R:L114	3.65	No	No	0	5	6
93	R:R:F115	R:R:F177	16.08	No	No	0	5	5
94	R:R:C174	R:R:Y116	5.38	No	No	0	4	5
95	R:R:A170	R:R:T119	3.36	No	No	0	7	5
96	R:R:L173	R:R:T119	4.42	No	No	0	5	5
97	R:R:F211	R:R:T119	3.89	Yes	No	0	5	5
98	R:R:F211	R:R:S123	3.96	Yes	No	1	5	6
99	R:R:N215	R:R:S123	4.47	Yes	No	1	6	6
100	R:R:I162	R:R:V124	3.07	No	Yes	0	7	7
101	R:R:V124	R:R:W163	8.58	Yes	No	0	7	9
102	R:R:S166	R:R:V124	4.85	No	Yes	0	8	7
103	R:R:I126	R:R:P219	3.39	No	No	0	8	9
104	R:R:I126	R:R:W277	11.74	No	Yes	0	8	9
105	R:R:L129	R:R:Y321	7.03	No	No	0	8	9
106	R:R:A130	R:R:P219	3.74	No	No	0	7	9
107	R:R:R136	R:R:V132	3.92	No	No	0	9	8
108	R:R:S133	R:R:S226	3.26	No	No	0	8	5
109	R:R:S133	R:R:Y227	7.63	No	Yes	0	8	9
110	R:R:L134	R:R:V138	2.98	No	No	0	5	4
111	R:R:L134	R:R:V222	2.98	No	No	0	5	6
112	R:R:R136	R:R:Y227	5.14	No	Yes	0	9	9
113	R:R:R136	R:R:Y321	3.09	No	No	0	9	9
114	R:R:M137	R:R:V138	3.04	Yes	No	0	8	4
115	R:R:M137	R:R:S226	4.6	Yes	No	0	8	5
116	R:R:K229	R:R:M137	5.76	No	Yes	0	5	8
117	R:R:I230	R:R:M137	4.37	No	Yes	0	8	8
118	R:R:H142	R:R:V138	2.77	No	No	0	5	4
119	R:R:I140	R:R:I230	4.42	No	No	0	8	8
120	R:R:R145	R:R:V141	3.92	No	No	0	5	6
121	R:R:H142	R:R:R145	7.9	No	No	0	5	5
122	R:R:H142	R:R:V147	5.54	No	No	0	5	5
123	R:R:G149	R:R:R148	4.5	No	No	0	4	4
124	R:R:G151	R:R:R148	4.5	No	No	0	7	4
125	R:R:G149	R:R:P150	4.06	No	No	0	4	6
126	R:R:A169	R:R:Y165	4	No	No	0	5	4
127	R:R:N215	R:R:Y165	3.49	Yes	No	0	6	4
128	R:R:P172	R:R:W207	4.05	No	Yes	0	8	6
129	R:R:L173	R:R:L196	2.77	No	No	0	5	5
130	R:R:C174	R:R:V175	3.42	No	No	0	4	4
131	R:R:F176	R:R:V175	5.24	No	No	0	5	4
132	R:R:F176	R:R:W198	5.01	No	Yes	0	5	7
133	R:R:F176	R:R:P199	7.22	No	No	0	5	6
134	R:R:C194	R:R:F177	4.19	No	No	0	9	5
135	R:R:F177	R:R:L196	9.74	No	No	0	5	5
136	R:R:S192	R:R:V179	3.23	No	No	0	3	5
137	R:R:E190	R:R:P181	3.14	No	No	0	3	2
138	R:R:I193	R:R:Q182	9.61	No	No	0	4	2
139	R:R:I191	R:R:L184	7.14	Yes	Yes	0	4	2
140	R:R:I191	R:R:Q189	9.61	Yes	No	0	4	1
141	R:R:L196	R:R:W198	10.25	No	Yes	0	5	7
142	R:R:E204	R:R:W198	35.98	No	Yes	0	5	7
143	R:R:W198	R:R:W207	4.69	Yes	Yes	0	7	6
144	R:R:P202	R:R:T200	6.99	No	No	0	3	3
145	R:R:I201	R:R:P202	3.39	No	No	0	4	3
146	R:R:I201	R:R:I205	2.94	No	No	0	4	4
147	R:R:E204	R:R:N291	3.94	No	No	0	5	2
148	R:R:I205	R:R:L288	4.28	No	No	0	4	4
149	R:R:D208	R:R:W207	3.35	Yes	Yes	0	5	6
150	R:R:F211	R:R:W207	11.02	Yes	Yes	0	5	6
151	R:R:D208	R:R:I284	4.2	Yes	No	1	5	5
152	R:R:D208	R:R:L288	5.43	Yes	No	0	5	4
153	R:R:F211	R:R:N215	8.46	Yes	Yes	1	5	6
154	R:R:I281	R:R:V212	3.07	No	No	0	7	6
155	R:R:F216	R:R:L217	3.65	No	No	0	8	4
156	R:R:P219	R:R:V218	3.53	No	No	0	9	5
157	R:R:F273	R:R:G220	4.52	No	No	0	9	6
158	R:R:F273	R:R:I223	3.77	No	No	0	9	8
159	R:R:M270	R:R:V224	4.56	No	No	0	8	5
160	R:R:L269	R:R:Y227	3.52	Yes	Yes	0	8	9
161	R:R:F263	R:R:L231	3.65	No	No	0	7	6
162	R:R:L231	R:R:L266	4.15	No	No	0	6	8
163	R:R:L262	R:R:T234	4.42	No	No	0	8	8
164	R:R:F263	R:R:K235	8.69	No	No	0	7	5
165	R:R:D259	R:R:R238	13.1	No	No	0	7	4
166	R:R:L245	R:R:R240	4.86	No	No	0	3	3
167	R:R:L241	R:R:L245	4.15	No	No	0	5	3
168	R:R:Q252	R:R:T242	4.25	Yes	No	0	2	4
169	R:R:S244	R:R:V243	4.85	No	No	0	5	2
170	R:R:H251	R:R:Y247	4.36	No	No	0	2	4
171	R:R:H251	R:R:S248	12.55	No	No	0	2	6
172	R:R:D259	R:R:S256	5.89	No	No	0	7	4
173	R:R:Q258	R:R:R261	10.51	No	No	0	6	8
174	R:R:D259	R:R:F263	5.97	No	No	0	7	7
175	R:R:F260	R:R:R264	6.41	No	No	0	6	7
176	R:R:L262	R:R:L266	5.54	No	No	0	8	8
177	R:R:L269	R:R:T265	2.95	Yes	No	0	8	8
178	R:R:F267	R:R:V271	3.93	No	No	0	5	5
179	R:R:L268	R:R:L320	2.77	No	Yes	0	6	8
180	R:R:L269	R:R:L320	5.54	Yes	Yes	0	8	8
181	R:R:L269	R:R:Y321	3.52	Yes	No	0	8	9
182	R:R:I275	R:R:V271	3.07	No	No	0	5	5
183	R:R:L320	R:R:S272	3	Yes	No	0	8	6
184	R:R:F273	R:R:F274	9.65	No	No	0	9	6
185	R:R:F309	R:R:M276	3.73	No	Yes	0	7	8
186	R:R:M276	R:R:N313	8.41	Yes	No	0	8	9
187	R:R:L316	R:R:M276	2.83	No	Yes	0	6	8
188	R:R:T310	R:R:W277	3.64	No	Yes	0	8	9
189	R:R:N313	R:R:W277	22.6	No	Yes	0	9	9
190	R:R:P279	R:R:S278	3.56	No	No	0	9	7
191	R:R:F309	R:R:P279	5.78	No	No	0	7	9
192	R:R:I280	R:R:I281	2.94	No	No	0	6	7
193	R:R:I280	R:R:V306	3.07	No	No	0	6	6
194	R:R:I280	R:R:T310	6.08	No	No	0	6	8
195	R:R:T283	R:R:V306	6.35	No	No	0	5	6
196	R:R:L286	R:R:L296	2.77	No	Yes	0	5	5
197	R:R:I287	R:R:N291	2.83	No	No	0	5	2
198	R:R:I289	R:R:L296	4.28	No	Yes	0	4	5
199	R:R:L296	R:R:Q290	5.32	Yes	No	3	5	4
200	R:R:I298	R:R:Q290	12.35	No	No	3	3	4
201	R:R:F292	R:R:K293	6.2	No	No	0	1	1
202	R:R:D295	R:R:K293	4.15	No	No	0	3	1
203	R:R:I298	R:R:L296	2.85	No	Yes	3	3	5
204	R:R:V297	R:R:W299	4.9	No	No	0	4	4
205	R:R:F311	R:R:V307	3.93	No	No	0	7	5
206	R:R:L316	R:R:L320	2.77	No	Yes	0	6	8
207	R:R:L127	R:R:N215	2.75	No	Yes	0	6	6
208	R:R:I253	R:R:Q252	2.74	No	Yes	0	3	2
209	R:R:D208	R:R:L285	2.71	Yes	No	0	5	6
210	R:R:D295	R:R:L296	2.71	No	Yes	0	3	5
211	R:R:F216	R:R:S278	2.64	No	No	0	8	7
212	R:R:R24	R:R:T195	2.59	No	No	0	5	4
213	R:R:I197	R:R:R178	2.51	No	No	0	4	4
214	R:R:I223	R:R:Y227	2.42	No	Yes	0	8	9
215	R:R:L214	R:R:Y165	2.34	No	No	0	4	4
216	R:R:L266	R:R:Y227	2.34	No	Yes	0	8	9
217	R:R:L241	R:R:Y247	2.34	No	No	0	5	4
218	R:R:R67	R:R:R69	2.13	No	No	0	6	7
219	R:R:G57	R:R:P318	2.03	No	No	0	9	9
220	R:R:F304	R:R:W305	2	Yes	No	0	4	4
221	R:R:C139	R:R:P150	1.88	No	No	0	8	6
222	R:R:A73	R:R:P150	1.87	No	No	0	6	6
223	R:R:G203	R:R:S206	1.86	No	No	0	3	4
224	R:R:G203	R:R:T200	1.82	No	No	0	3	3
225	R:R:P26	R:R:S29	1.78	No	No	0	5	9
226	R:R:P181	R:R:V180	1.77	No	No	0	2	4
227	R:R:G33	R:R:K32	1.74	No	No	0	3	3
228	R:R:G107	R:R:L106	1.71	No	Yes	0	8	6
229	R:R:A75	R:R:V65	1.7	No	No	0	8	7
230	R:R:I92	R:R:P93	1.69	No	No	0	7	9
231	R:R:D34	R:R:G33	1.68	No	No	0	3	3
232	R:R:L171	R:R:P172	1.64	No	No	0	5	8
233	R:R:L184	R:R:P185	1.64	Yes	No	0	2	1
234	R:R:S248	R:R:S250	1.63	No	No	0	6	5
235	R:R:A103	R:R:I191	1.62	No	Yes	0	5	4
236	R:R:S121	R:R:V117	1.62	No	No	0	8	4
237	R:R:A312	R:R:M276	1.61	No	Yes	0	5	8
238	R:R:T44	R:R:V48	1.59	No	No	0	6	4
239	R:R:C60	R:R:L56	1.59	No	No	0	6	4
240	R:R:C83	R:R:L62	1.59	No	No	0	5	6
241	R:R:T195	R:R:V180	1.59	No	No	0	4	4
242	R:R:T213	R:R:V209	1.59	No	No	0	5	4
243	R:R:A308	R:R:L47	1.58	No	No	0	4	6
244	R:R:A167	R:R:L120	1.58	No	No	0	3	5
245	R:R:A131	R:R:L158	1.58	No	No	0	7	5
246	R:R:A187	R:R:L184	1.58	No	Yes	0	3	2
247	R:R:I50	R:R:S54	1.55	No	Yes	0	7	8
248	R:R:I282	R:R:S278	1.55	No	No	0	5	7
249	R:R:K239	R:R:V243	1.52	No	No	0	5	2
250	R:R:M270	R:R:V271	1.52	No	No	0	8	5
251	R:R:G72	R:R:R71	1.5	No	Yes	0	7	7
252	R:R:L120	R:R:S166	1.5	No	No	0	5	8
253	R:R:L214	R:R:S210	1.5	No	No	0	4	4
254	R:R:K239	R:R:T242	1.5	No	No	0	5	4
255	R:R:L302	R:R:V306	1.49	No	No	0	5	6
256	R:R:I191	R:R:I193	1.47	Yes	No	0	4	4
257	R:R:L217	R:R:T213	1.47	No	No	0	4	5
258	R:R:I223	R:R:M270	1.46	No	No	0	8	8
259	R:R:F25	R:R:P300	1.44	Yes	No	0	5	4
260	R:R:Q252	R:R:S248	1.44	Yes	No	0	2	6
261	R:R:E102	R:R:V31	1.43	No	No	0	4	6
262	R:R:I225	R:R:L221	1.43	No	No	0	4	2
263	R:R:Q252	R:R:V255	1.43	Yes	No	0	2	5
264	R:R:L47	R:R:L96	1.38	No	No	0	6	6
265	R:R:L55	R:R:L86	1.38	No	No	0	5	7
266	R:R:A66	R:R:R71	1.38	No	Yes	0	1	7
267	R:R:A75	R:R:R71	1.38	No	Yes	0	8	7
268	R:R:P300	R:R:W299	1.35	No	No	0	4	4
269	R:R:Q257	R:R:Q258	1.28	No	No	0	5	6
270	R:R:K32	R:R:R36	1.24	No	No	0	3	4
271	R:R:S301	R:R:W299	1.24	No	No	0	2	4
272	R:R:T101	R:R:W100	1.21	No	Yes	0	4	5
273	R:R:L241	R:R:R238	1.21	No	No	0	5	4
274	R:R:R261	R:R:R264	1.07	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.139	10	1	0
2	R:R:F25	5.14	5	0	5
3	R:R:F28	5.4825	4	0	8
4	R:R:S54	4.42	4	6	8
5	R:R:R71	1.865	4	0	7
6	R:R:L81	4.8025	4	0	9
7	R:R:F82	5.83	4	0	9
8	R:R:D85	5.53	4	0	9
9	R:R:F88	6.0325	4	1	7
10	R:R:W100	4.5175	4	5	5
11	R:R:W104	9.27	4	2	9
12	R:R:L106	2.9975	4	0	6
13	R:R:V124	4.9725	4	0	7
14	R:R:M137	4.4425	4	0	8
15	R:R:L184	4.4525	4	0	2
16	R:R:I191	4.96	4	0	4
17	R:R:W198	13.9825	4	0	7
18	R:R:W207	5.7775	4	0	6
19	R:R:D208	4.58	5	1	5
20	R:R:F211	6.576	5	1	5
21	R:R:N215	4.7925	4	1	6
22	R:R:Y227	4.21	5	0	9
23	R:R:Q252	2.465	4	0	2
24	R:R:L269	3.8825	4	0	8
25	R:R:M276	4.145	4	0	8
26	R:R:W277	10.7925	4	0	9
27	R:R:L296	3.586	5	3	5
28	R:R:F304	7.83	5	4	4
29	R:R:L320	3.52	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I287	50.8627	6.5	Yes	No	0	0	5
2	R:R:F25	R:R:I287	55.2704	6.28	Yes	No	0	5	5
3	R:R:F25	R:R:P26	39.0556	7.22	Yes	No	0	5	5
4	R:R:P26	R:R:S29	37.7894	1.78	No	No	0	5	9
5	R:R:I193	R:R:S29	36.5135	4.64	No	No	0	4	9
6	R:R:I193	R:R:Q182	13.3923	9.61	No	No	0	4	2
7	R:R:Q182	R:R:R24	10.4828	3.5	No	No	0	2	5
8	R:R:F25	R:R:I298	11.9231	7.54	Yes	No	0	5	3
9	L:L:?1	R:R:F88	29.6216	4.62	Yes	Yes	1	0	7
10	R:R:F311	R:R:F88	25.6778	8.57	No	Yes	0	7	7
11	R:R:F311	R:R:V307	24.6726	3.93	No	No	0	7	5
12	R:R:F28	R:R:V307	23.6818	5.24	Yes	No	0	8	5
13	R:R:F28	R:R:F304	15.2192	3.22	Yes	Yes	0	8	4
14	R:R:I191	R:R:I193	23.2227	1.47	Yes	No	0	4	4
15	R:R:I191	R:R:L184	17.6357	7.14	Yes	Yes	0	4	2
16	R:R:L184	R:R:V31	13.344	7.45	Yes	No	0	2	6
17	R:R:E102	R:R:V31	11.8941	1.43	No	No	0	4	6
18	R:R:E102	R:R:R36	10.4345	13.96	No	No	0	4	4
19	R:R:F304	R:R:L47	10.3185	4.87	Yes	No	0	4	6
20	L:L:?1	R:R:W277	99.7245	5.19	Yes	Yes	0	0	9
21	R:R:N313	R:R:W277	100	22.6	No	Yes	0	9	9
22	R:R:M276	R:R:N313	99.9565	8.41	Yes	No	0	8	9
23	R:R:L316	R:R:M276	98.9899	2.83	No	Yes	0	6	8
24	R:R:L316	R:R:L320	98.8401	2.77	No	Yes	0	6	8
25	R:R:L269	R:R:L320	98.3326	5.54	Yes	Yes	0	8	8
26	R:R:L269	R:R:Y321	53.6755	3.52	Yes	No	0	8	9
27	R:R:L129	R:R:Y321	48.364	7.03	No	No	0	8	9
28	R:R:L129	R:R:L81	47.1896	5.54	No	Yes	0	8	9
29	R:R:L81	R:R:N317	27.0842	4.12	Yes	No	0	9	9
30	R:R:D85	R:R:N317	25.7455	6.73	Yes	No	0	9	9
31	R:R:D85	R:R:S314	13.2618	4.42	Yes	No	0	9	9
32	R:R:D85	R:R:N58	10.3813	8.08	Yes	No	0	9	9
33	R:R:L269	R:R:Y227	60.7172	3.52	Yes	Yes	0	8	9
34	R:R:R136	R:R:Y227	28.6163	5.14	No	Yes	0	9	9
35	R:R:R136	R:R:V132	38.0117	3.92	No	No	0	9	8
36	R:R:L77	R:R:V132	36.0978	2.98	No	No	0	7	8
37	R:R:E135	R:R:L77	34.1743	5.3	No	No	0	8	7
38	R:R:A73	R:R:E135	30.2982	4.53	No	No	0	6	8
39	R:R:A73	R:R:R155	18.438	8.3	No	No	0	6	6
40	R:R:C76	R:R:R155	16.4274	4.18	No	No	0	5	6
41	R:R:C76	R:R:L79	14.4072	3.17	No	No	0	5	5
42	R:R:R136	R:R:Y321	27.7464	3.09	No	No	0	9	9
43	R:R:L79	R:R:V65	12.3774	2.98	No	No	0	5	7
44	R:R:A75	R:R:V65	10.3378	1.7	No	No	0	8	7
45	R:R:L81	R:R:T128	14.6875	5.9	Yes	No	0	9	8
46	R:R:N80	R:R:T128	13.2618	7.31	No	No	0	9	8
47	R:R:N80	R:R:W163	10.3813	6.78	No	No	0	9	9
48	R:R:F115	R:R:F28	10.5263	4.29	No	Yes	0	5	8
49	R:R:F115	R:R:L114	17.3554	3.65	No	No	0	5	6
50	R:R:L114	R:R:L94	14.9099	5.54	No	No	0	6	5
51	R:R:L106	R:R:L94	12.4934	4.15	Yes	No	0	6	5
52	L:L:?1	R:R:E204	30.6413	3.02	Yes	No	0	0	5
53	R:R:E204	R:R:W198	35.0442	35.98	No	Yes	0	5	7
54	R:R:L196	R:R:W198	31.4436	10.25	No	Yes	0	5	7
55	R:R:F177	R:R:L196	31.5016	9.74	No	No	0	5	5
56	R:R:F115	R:R:F177	12.967	16.08	No	No	0	5	5
57	R:R:C194	R:R:F177	19.0083	4.19	No	No	0	9	5
58	R:R:C194	R:R:W104	13.0008	16.98	No	Yes	2	9	9
59	R:R:G107	R:R:L106	11.6669	1.71	No	Yes	0	8	6
60	L:L:?1	R:R:F211	15.1757	5.55	Yes	Yes	1	0	5
61	R:R:S133	R:R:Y227	18.3413	7.63	No	Yes	0	8	9
62	R:R:S133	R:R:S226	16.9881	3.26	No	No	0	8	5
63	R:R:M137	R:R:S226	15.6252	4.6	Yes	No	0	8	5
64	R:R:M137	R:R:V138	10.0768	3.04	Yes	No	0	8	4
65	R:R:A73	R:R:P150	10.3378	1.87	No	No	0	6	6
66	L:L:?1	R:R:D208	13.2183	7.21	Yes	Yes	1	0	5
67	R:R:F309	R:R:M276	10.8211	3.73	No	Yes	0	7	8
68	R:R:I223	R:R:Y227	12.8703	2.42	No	Yes	0	8	9
69	R:R:L266	R:R:Y227	31.2068	2.34	No	Yes	0	8	9
70	R:R:L231	R:R:L266	27.4757	4.15	No	No	0	6	8
71	R:R:F263	R:R:L231	26.1805	3.65	No	No	0	7	6
72	R:R:D259	R:R:F263	23.648	5.97	No	No	0	7	7
73	R:R:D259	R:R:R238	21.0091	13.1	No	No	0	7	4
74	R:R:L241	R:R:R238	19.6849	1.21	No	No	0	5	4
75	R:R:L241	R:R:Y247	15.6252	2.34	No	No	0	5	4
76	R:R:H251	R:R:Y247	14.2526	4.36	No	No	0	2	4
77	R:R:H251	R:R:S248	12.8703	12.55	No	No	0	2	6
78	R:R:Q252	R:R:S248	10.0768	1.44	Yes	No	0	2	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F27	4.62	1	Yes	No	0	5	0	1
L:L:?1	R:R:F88	4.62	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M118	6.44	1	Yes	No	0	7	0	1
L:L:?1	R:R:G122	3.9	1	Yes	No	0	7	0	1
L:L:?1	R:R:E204	3.02	1	Yes	No	0	5	0	1
L:L:?1	R:R:D208	7.21	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F211	5.55	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W277	5.19	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:I284	4.34	1	Yes	No	0	5	0	1
L:L:?1	R:R:I287	6.5	1	Yes	No	0	5	0	1
R:R:F25	R:R:I287	6.28	0	Yes	No	5	5	2	1
R:R:F25	R:R:F303	3.22	0	Yes	No	5	4	2	2
R:R:F27	R:R:F303	6.43	0	No	No	5	4	1	2
R:R:F88	R:R:S121	7.93	1	Yes	No	7	8	1	2
R:R:F88	R:R:G122	3.01	1	Yes	No	7	7	1	1
R:R:F311	R:R:F88	8.57	0	No	Yes	7	7	2	1
R:R:A91	R:R:M118	3.22	0	No	No	6	7	2	1
R:R:F211	R:R:T119	3.89	1	Yes	No	5	5	1	2
R:R:F211	R:R:S123	3.96	1	Yes	No	5	6	1	2
R:R:N215	R:R:S123	4.47	1	Yes	No	6	6	2	2
R:R:I126	R:R:W277	11.74	0	No	Yes	8	9	2	1
R:R:E204	R:R:W198	35.98	0	No	Yes	5	7	1	2
R:R:W198	R:R:W207	4.69	0	Yes	Yes	7	6	2	2
R:R:E204	R:R:N291	3.94	0	No	No	5	2	1	2
R:R:D208	R:R:W207	3.35	1	Yes	Yes	5	6	1	2
R:R:F211	R:R:W207	11.02	1	Yes	Yes	5	6	1	2
R:R:D208	R:R:I284	4.2	1	Yes	No	5	5	1	1
R:R:D208	R:R:L288	5.43	1	Yes	No	5	4	1	2
R:R:F211	R:R:N215	8.46	1	Yes	Yes	5	6	1	2
R:R:T310	R:R:W277	3.64	0	No	Yes	8	9	2	1
R:R:N313	R:R:W277	22.6	0	No	Yes	9	9	2	1
R:R:I287	R:R:N291	2.83	0	No	No	5	2	1	2
R:R:D208	R:R:L285	2.71	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8H4L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	264
Number of Links	274
Number of Hubs	29
Number of Links mediated by Hubs	115
Number of Communities	6
Number of Nodes involved in Communities	24
Number of Links involved in Communities	27

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	40959
Length Of Smallest Path	3
Average Path Length	15.0861
Length of Longest Path	36
Minimum Path Strength	1.295
Average Path Strength	6.00973
Maximum Path Strength	23.115
Minimum Path Correlation	0.7
Average Path Correlation	0.945298
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	60.4997
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.7066
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • arrestin family protein binding • fatty acid binding • organic acid binding • ion binding • anion binding • lipid binding • carboxylic acid binding • monocarboxylic acid binding • small molecule binding • taste receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of peptide secretion • transport • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion • somatostatin secretion • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of somatostatin secretion • peptide secretion • localization • secretion by cell • regulation of secretion by cell • negative regulation of secretion • amide transport • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of peptide hormone secretion • regulation of signaling • negative regulation of peptide hormone secretion • secretion • regulation of transport • regulation of hormone levels • regulation of peptide transport • export from cell • establishment of localization • regulation of secretion • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • hexose transmembrane transport • carbohydrate transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • ghrelin secretion • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of osteoblast differentiation • cellular developmental process • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • cell differentiation • fat cell differentiation • positive regulation of brown fat cell differentiation • positive regulation of fat cell differentiation • regulation of brown fat cell differentiation • brown fat cell differentiation • regulation of fat cell differentiation • glucagon secretion • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • regulation of glucagon secretion • positive regulation of peptide secretion • positive regulation of glucagon secretion • positive regulation of peptide hormone secretion • positive regulation of transport • white fat cell differentiation • intracellular vesicle • cytoplasmic vesicle • endocytic vesicle • ciliary membrane • plasma membrane region • cell projection membrane • endosome membrane • endosome • cytoplasmic vesicle membrane • vesicle membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HXA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HXA
Name	Doconexent
Synonyms	DHA
Identifier
Formula	C22 H32 O2
Molecular Weight	328.488
SMILES
PubChem	445580
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5NUL3
Sequence	>8H4L_nogp_Chain_R N R T R F P F F S D V K G D H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R R R R G A T A C L V L N L F C A D L L F I S A I P L V L A V R W T E A W L L G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H L Q R G V R G P G R R A R A V L L A L I W G Y S A V A A L P L C V F F R V V P Q R L P G A D Q E I S I C T L I W P T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L A Y S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q D L V I W P S L F F W V V A F T F A N S A L N P I L Y N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8T3Q	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.14	2024-01-24	10.1126/sciadv.adj2384
	8T3Q (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.14	2024-01-24	10.1126/sciadv.adj2384
	8T3O	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	2Y5	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.06	2024-01-17	10.1126/sciadv.adj2384
	8T3O (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	2Y5		3.06	2024-01-17	10.1126/sciadv.adj2384
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	10.1038/s41422-023-00835-x
	8IYS	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP	chim(NtGi1L-Gq)/β1/γ2	2.95	2023-06-21	10.1038/s41422-023-00835-x
	8IYS (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP		2.95	2023-06-21	10.1038/s41422-023-00835-x
	8ID9	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-	Gi1/β1/γ2	3	2023-03-15	10.1126/science.add6220
	8ID9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-		3	2023-03-15	10.1126/science.add6220
	8ID8	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	Gi1/β1/γ2	3	2023-03-15	10.1126/science.add6220
	8ID8 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3	2023-03-15	10.1126/science.add6220
	8ID6	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-	Gi1/β1/γ2	2.8	2023-03-15	10.1126/science.add6220
	8ID6 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-		2.8	2023-03-15	10.1126/science.add6220
	8ID4	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-	Gi1/β1/γ2	3.1	2023-03-15	10.1126/science.add6220
	8ID4 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-		3.1	2023-03-15	10.1126/science.add6220
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	10.1126/science.add6220
	8G59	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(Gi1-CtGq)/β1/γ2	2.64	2023-03-08	10.1126/science.add6220
	8G59 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		2.64	2023-03-08	10.1126/science.add6220

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