Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 6.81375800
2R:R:F25 7.33667625
3R:R:F27 8.755425
4R:R:K32 5.8575433
5R:R:E43 9.9475435
6R:R:T44 3.5406
7R:R:S54 5.09408
8R:R:N58 7.572509
9R:R:L77 3.7625407
10R:R:N80 7.332549
11R:R:L81 6.4625419
12R:R:F82 4.47667609
13R:R:F88 6.946507
14R:R:I89 5.434566
15R:R:I92 7.96567
16R:R:W104 11.0725459
17R:R:C111 4.118559
18R:R:S133 5.2425418
19R:R:M137 3.57508
20R:R:W163 9.238549
21R:R:C194 7.955459
22R:R:T195 5.3925404
23R:R:W207 12.202506
24R:R:F211 10.015405
25R:R:N215 6.24406
26R:R:Y227 5.88571719
27R:R:F273 5.898579
28R:R:M276 6.4625408
29R:R:W277 12.715479
30R:R:F303 5.446524
31R:R:F304 10.665434
32R:R:W305 4.055404
33R:R:F311 6.4925407
34R:R:L320 4.2225498
35R:R:Y321 6.9225419
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:I287 21.90264.02YesNo005
2R:R:F25 R:R:I287 16.91476.28YesNo255
3R:R:F25 R:R:P26 16.69717.22YesNo055
4L:L:?1 R:R:L196 21.43196.83YesNo005
5R:R:F27 R:R:L196 17.78826.09YesNo055
6L:L:?1 R:R:F88 73.31365.15YesYes007
7R:R:F311 R:R:F88 18.212710.72YesYes077
8R:R:F311 R:R:V307 28.41715.24YesNo075
9R:R:F28 R:R:V95 29.184510.49NoNo086
10R:R:F304 R:R:V95 27.7642.62YesNo046
11R:R:E43 R:R:F304 12.471113.99YesYes354
12R:R:F311 R:R:I92 22.99656.28YesYes077
13R:R:I92 R:R:L47 10.74869.99YesNo076
14R:R:I89 R:R:I92 22.19385.89YesYes667
15R:R:F88 R:R:S314 86.00515.28YesNo079
16R:R:S314 R:R:S54 43.87334.89NoYes098
17R:R:I89 R:R:S54 11.8679.29YesYes068
18R:R:N58 R:R:S54 53.5774.47YesYes098
19R:R:D85 R:R:S314 42.39577.36NoNo099
20R:R:D85 R:R:N58 42.273317.5NoYes099
21R:R:F82 R:R:N58 1003.62YesYes099
22R:R:I89 R:R:L86 11.67924.28YesNo067
23R:R:L86 R:R:N58 11.54054.12NoYes079
24R:R:F82 R:R:L81 90.76716.09YesYes099
25R:R:L129 R:R:L81 78.76134.15NoYes189
26R:R:L129 R:R:Y321 78.00488.21NoYes189
27R:R:L81 R:R:T128 14.24537.37YesNo098
28R:R:N80 R:R:T128 12.97727.31YesNo098
29R:R:F115 R:R:F27 18.62917.5NoYes055
30R:R:F115 R:R:F177 16.030415NoNo055
31L:L:?1 R:R:F211 19.81556.87YesYes005
32L:L:?1 R:R:D208 10.28069.56YesNo005
33L:L:?1 R:R:I280 28.80089.05YesNo006
34R:R:I280 R:R:T310 24.16126.08NoNo068
35R:R:T310 R:R:W277 23.2173.64NoYes089
36R:R:R136 R:R:Y321 33.9225.14NoYes199
37R:R:R136 R:R:Y227 33.55197.2NoYes199
38R:R:L269 R:R:Y321 34.022710.55NoYes089
39R:R:L269 R:R:Y227 32.93975.86NoYes089
40R:R:S226 R:R:Y227 23.50816.36NoYes159
41R:R:M137 R:R:S226 21.3044.6YesNo085
42R:R:P172 R:R:W207 10.364916.21NoYes086
43R:R:L266 R:R:Y227 23.16535.86NoYes089
44R:R:L231 R:R:L266 16.41414.15NoNo068
45R:R:K235 R:R:L231 11.71192.82NoNo056
46R:R:N313 R:R:W277 10.446527.12NoYes099
47R:R:F28 R:R:V307 23.91369.18NoNo285
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F88 5.15 0 Yes Yes 0 7 0 1
L:L:?1 R:R:M118 4.98 0 Yes No 0 7 0 1
L:L:?1 R:R:L196 6.83 0 Yes No 0 5 0 1
L:L:?1 R:R:D208 9.56 0 Yes No 0 5 0 1
L:L:?1 R:R:F211 6.87 0 Yes Yes 0 5 0 1
L:L:?1 R:R:I280 9.05 0 Yes No 0 6 0 1
L:L:?1 R:R:I284 8.05 0 Yes No 0 5 0 1
L:L:?1 R:R:I287 4.02 0 Yes No 0 5 0 1
R:R:F25 R:R:F27 12.86 2 Yes Yes 5 5 2 2
R:R:F25 R:R:I287 6.28 2 Yes No 5 5 2 1
R:R:F25 R:R:F303 5.36 2 Yes Yes 5 4 2 2
R:R:F27 R:R:L196 6.09 2 Yes No 5 5 2 1
R:R:F27 R:R:F303 8.57 2 Yes Yes 5 4 2 2
R:R:F88 R:R:S121 10.57 0 Yes No 7 8 1 2
R:R:F311 R:R:F88 10.72 0 Yes Yes 7 7 2 1
R:R:F88 R:R:S314 5.28 0 Yes No 7 9 1 2
R:R:F311 R:R:M118 3.73 0 Yes No 7 7 2 1
R:R:F211 R:R:T119 3.89 0 Yes No 5 5 1 2
R:R:L196 R:R:W198 9.11 0 No No 5 7 1 2
R:R:W198 R:R:W207 10.31 0 No Yes 7 6 2 2
R:R:D208 R:R:W207 4.47 0 No Yes 5 6 1 2
R:R:F211 R:R:W207 22.05 0 Yes Yes 5 6 1 2
R:R:D208 R:R:L288 12.21 0 No No 5 4 1 2
R:R:F211 R:R:N215 7.25 0 Yes Yes 5 6 1 2
R:R:I280 R:R:T283 4.56 0 No No 6 5 1 2
R:R:I280 R:R:T310 6.08 0 No No 6 8 1 2
R:R:F303 R:R:I287 3.77 2 Yes No 4 5 2 1
R:R:A91 R:R:M118 3.22 0 No No 6 7 2 1
R:R:F88 R:R:G122 3.01 0 Yes No 7 7 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8ID9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.62
Number of Linked Nodes 250
Number of Links 267
Number of Hubs 35
Number of Links mediated by Hubs 139
Number of Communities 9
Number of Nodes involved in Communities 41
Number of Links involved in Communities 50
Path Summary
Number Of Nodes in MetaPath 48
Number Of Links MetaPath 47
Number of Shortest Paths 58013
Length Of Smallest Path 3
Average Path Length 14.0864
Length of Longest Path 27
Minimum Path Strength 1.405
Average Path Strength 6.50926
Maximum Path Strength 20.605
Minimum Path Correlation 0.7
Average Path Correlation 0.93854
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5
Average % Of Corr. Nodes 57.0694
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.8589
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • arrestin family protein binding   • fatty acid binding   • organic acid binding   • lipid binding   • carboxylic acid binding   • monocarboxylic acid binding   • taste receptor activity   • positive regulation of cytosolic calcium ion concentration   • somatostatin secretion   • negative regulation of somatostatin secretion   • regulation of somatostatin secretion   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • cell death   • negative regulation of apoptotic process   • apoptotic process   • programmed cell death   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • defense response   • negative regulation of response to stimulus   • response to external stimulus   • regulation of inflammatory response   • response to stress   • negative regulation of response to external stimulus   • regulation of response to stress   • negative regulation of defense response   • inflammatory response   • hexose transmembrane transport   • carbohydrate transport   • transmembrane transport   • regulation of transmembrane transport   • D-glucose transmembrane transport   • regulation of D-glucose transmembrane transport   • monosaccharide transmembrane transport   • carbohydrate transmembrane transport   • multicellular organismal process   • interleukin-1 production   • regulation of interleukin-1 beta production   • negative regulation of interleukin-1 beta production   • negative regulation of interleukin-1 production   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • negative regulation of macromolecule metabolic process   • regulation of interleukin-1 production   • negative regulation of metabolic process   • negative regulation of cytokine production   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • negative regulation of gene expression   • negative regulation of biosynthetic process   • interleukin-1 beta production   • negative regulation of macromolecule biosynthetic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • negative regulation of multicellular organismal process   • ghrelin secretion   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • developmental process   • regulation of osteoblast differentiation   • cellular developmental process   • regulation of developmental process   • regulation of cell differentiation   • osteoblast differentiation   • positive regulation of developmental process   • positive regulation of osteoblast differentiation   • ossification   • positive regulation of cell differentiation   • cell differentiation   • phospholipase C-activating G protein-coupled receptor signaling pathway   • fat cell differentiation   • positive regulation of brown fat cell differentiation   • positive regulation of fat cell differentiation   • regulation of brown fat cell differentiation   • brown fat cell differentiation   • regulation of fat cell differentiation   • glucagon secretion   • positive regulation of secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • regulation of glucagon secretion   • positive regulation of peptide secretion   • positive regulation of glucagon secretion   • positive regulation of peptide hormone secretion   • positive regulation of transport   • white fat cell differentiation   • intracellular vesicle   • cytoplasmic vesicle   • endocytic vesicle   • ciliary membrane   • plasma membrane region   • cell projection membrane   • endosome membrane   • endosome   • cytoplasmic vesicle membrane   • vesicle membrane
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeEPA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeEPA
NameIcosapent
SynonymsEicosapentaenoic acid
Identifier
FormulaC20 H30 O2
Molecular Weight302.451
SMILES
PubChem446284
Formal Charge0
Total Atoms52
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ5NUL3
Sequence
>8ID9_nogp_Chain_R
TRFPFFSDV KGDHRLVLA AVETTVLVL IFAVSLLGN VCALVLVAR 
RRRRGALVL NLFCADLLF ISAIPLVLA VRWTEAWLL GPVACHLLF 
YVMTLSGSV TILTLAAVS LERMVCIVH LQGRRARAV LLALIWGYS 
AVAALPLCV FFRVVPISI CTLIWPTIP GEISWDVSF VTLNFLVPG 
LVIVISYSK ILQITKASR KRLTVSLES HQIRVSQQD FRLFRTLFL 
LMVSFFIMW SPIIITILL ILIQNFKLV IWPSLFFWV VAFTFANSA 
LNPILYNMT LCR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IYSALipidFree Fatty AcidFFA4Homo sapiensTUG-891GDPchim(NtGi1L-Gq)/β1/γ22.952023-06-21doi.org/10.1038/s41422-023-00835-x
8IYS (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensTUG-891GDP2.952023-06-21doi.org/10.1038/s41422-023-00835-x
8H4IALipidFree Fatty AcidFFA4Homo sapiensDoconexent-chim(NtGi1-Gs)/β1/γ23.062023-06-21doi.org/10.1038/s41422-023-00835-x
8H4I (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensDoconexent-3.062023-06-21doi.org/10.1038/s41422-023-00835-x
8H4KALipidFree Fatty AcidFFA4Homo sapiensGW9508-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-06-21doi.org/10.1038/s41422-023-00835-x
8H4K (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensGW9508-3.12023-06-21doi.org/10.1038/s41422-023-00835-x
8H4LALipidFree Fatty AcidFFA4Homo sapiensDoconexent-chim(NtGi1-Gs-CtGq)/β1/γ23.072023-06-21doi.org/10.1038/s41422-023-00835-x
8H4L (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensDoconexent-3.072023-06-21doi.org/10.1038/s41422-023-00835-x
8T3OALipidFree Fatty AcidFFA4Homo sapiensTUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ23.062024-01-17doi.org/10.1126/sciadv.adj2384
8T3O (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-3.062024-01-17doi.org/10.1126/sciadv.adj2384
8T3QALipidFree Fatty AcidFFA4Homo sapiensDocosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ23.142024-01-24doi.org/10.1126/sciadv.adj2384
8T3Q (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensDocosa-4,7,10,13,16,19-Hexaenoic acid-3.142024-01-24doi.org/10.1126/sciadv.adj2384
8G59ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-chim(Gi1-CtGq)/β1/γ22.642023-03-08doi.org/10.1126/science.add6220
8G59 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-2.642023-03-08doi.org/10.1126/science.add6220
8ID3ALipidFree Fatty AcidFFA4Homo sapiens9-Hydroxystearic acid-Gi1/β1/γ23.12023-03-15doi.org/10.1126/science.add6220
8ID3 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiens9-Hydroxystearic acid-3.12023-03-15doi.org/10.1126/science.add6220
8ID4ALipidFree Fatty AcidFFA4Homo sapiensLinoleic acid-Gi1/β1/γ23.12023-03-15doi.org/10.1126/science.add6220
8ID4 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensLinoleic acid-3.12023-03-15doi.org/10.1126/science.add6220
8ID6ALipidFree Fatty AcidFFA4Homo sapiensOleic acid-Gi1/β1/γ22.82023-03-15doi.org/10.1126/science.add6220
8ID6 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensOleic acid-2.82023-03-15doi.org/10.1126/science.add6220
8ID8ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-Gi1/β1/γ232023-03-15doi.org/10.1126/science.add6220
8ID8 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-32023-03-15doi.org/10.1126/science.add6220
8ID9ALipidFree Fatty AcidFFA4Homo sapiensEicosapentaenoic acid-Gi1/β1/γ232023-03-15doi.org/10.1126/science.add6220
8ID9 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensEicosapentaenoic acid-32023-03-15doi.org/10.1126/science.add6220




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ID9_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.