psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F88	4.1	Yes	Yes	0	0	7
2	L:L:?1	R:R:F115	11.47	Yes	Yes	1	0	5
3	L:L:?1	R:R:M118	9.51	Yes	Yes	1	0	7
4	L:L:?1	R:R:T119	10.9	Yes	Yes	1	0	5
5	L:L:?1	R:R:L173	3.72	Yes	Yes	1	0	5
6	L:L:?1	R:R:L196	3.72	Yes	Yes	1	0	5
7	L:L:?1	R:R:E204	4.46	Yes	Yes	1	0	5
8	L:L:?1	R:R:D208	7.3	Yes	Yes	1	0	5
9	L:L:?1	R:R:F211	9.01	Yes	Yes	1	0	5
10	L:L:?1	R:R:N215	3.69	Yes	Yes	1	0	6
11	L:L:?1	R:R:W277	6.89	Yes	Yes	0	0	9
12	L:L:?1	R:R:I280	18.24	Yes	No	0	0	6
13	L:L:?1	R:R:I281	4.8	Yes	No	0	0	7
14	L:L:?1	R:R:I284	15.36	Yes	No	1	0	5
15	L:L:?1	R:R:I287	9.6	Yes	No	1	0	5
16	R:R:Q294	R:R:R22	7.01	No	No	0	1	5
17	R:R:Q294	R:R:T23	7.09	No	No	0	1	8
18	R:R:R24	R:R:T195	6.47	No	No	0	5	4
19	R:R:I197	R:R:R24	6.26	No	No	0	4	5
20	R:R:F25	R:R:P26	5.78	Yes	No	0	5	5
21	R:R:F25	R:R:F27	7.5	Yes	Yes	1	5	5
22	R:R:F25	R:R:I287	5.02	Yes	No	1	5	5
23	R:R:F25	R:R:P300	4.33	Yes	No	0	5	4
24	R:R:F25	R:R:F303	9.65	Yes	Yes	1	5	4
25	R:R:F115	R:R:F27	9.65	Yes	Yes	1	5	5
26	R:R:F177	R:R:F27	7.5	Yes	Yes	1	5	5
27	R:R:F27	R:R:L196	6.09	Yes	Yes	1	5	5
28	R:R:F28	R:R:V95	13.11	Yes	No	0	8	6
29	R:R:F115	R:R:F28	7.5	Yes	Yes	1	5	8
30	R:R:F28	R:R:F303	5.36	Yes	Yes	1	8	4
31	R:R:F28	R:R:V307	7.87	Yes	No	1	8	5
32	R:R:I193	R:R:S29	6.19	No	No	0	4	9
33	R:R:D30	R:R:R99	14.29	Yes	No	0	6	4
34	R:R:D30	R:R:P300	4.83	Yes	No	0	6	4
35	R:R:R183	R:R:V31	6.54	No	No	0	3	6
36	R:R:D34	R:R:H35	21.43	No	No	0	3	3
37	R:R:E102	R:R:R36	19.77	No	No	0	4	4
38	R:R:E43	R:R:L39	5.3	No	No	0	5	4
39	R:R:E43	R:R:R99	12.79	No	No	3	5	4
40	R:R:E43	R:R:F304	11.66	No	Yes	3	5	4
41	R:R:L96	R:R:T44	5.9	Yes	No	4	6	6
42	R:R:T44	R:R:W100	18.19	No	No	4	6	5
43	R:R:I92	R:R:L47	8.56	Yes	No	0	7	6
44	R:R:F304	R:R:L47	6.09	Yes	No	0	4	6
45	R:R:F51	R:R:L55	4.87	No	No	5	6	5
46	R:R:F51	R:R:I89	3.77	No	No	5	6	6
47	R:R:F51	R:R:I92	6.28	No	Yes	0	6	7
48	R:R:I89	R:R:S54	9.29	No	No	0	6	8
49	R:R:S314	R:R:S54	4.89	No	No	0	9	8
50	R:R:I89	R:R:L55	4.28	No	No	5	6	5
51	R:R:G57	R:R:P318	4.06	No	No	0	9	9
52	R:R:F82	R:R:N58	3.62	Yes	Yes	0	9	9
53	R:R:D85	R:R:N58	12.12	Yes	Yes	0	9	9
54	R:R:L86	R:R:N58	4.12	No	Yes	0	7	9
55	R:R:N58	R:R:P318	14.66	Yes	No	0	9	9
56	R:R:A61	R:R:F82	8.32	No	Yes	0	8	9
57	R:R:F82	R:R:L62	7.31	Yes	No	0	9	6
58	R:R:L64	R:R:R68	3.64	No	Yes	0	7	6
59	R:R:R67	R:R:R71	8.53	No	No	0	6	7
60	R:R:L325	R:R:R68	3.64	No	Yes	0	8	6
61	R:R:A75	R:R:R69	4.15	No	No	0	8	7
62	R:R:R152	R:R:R69	5.33	No	No	0	3	7
63	R:R:C76	R:R:V78	5.12	No	No	0	5	8
64	R:R:F82	R:R:V78	5.24	Yes	No	0	9	8
65	R:R:N80	R:R:T128	10.24	No	No	0	9	8
66	R:R:L159	R:R:N80	9.61	No	No	0	7	9
67	R:R:N80	R:R:W163	6.78	No	Yes	0	9	9
68	R:R:D85	R:R:L81	4.07	Yes	Yes	2	9	9
69	R:R:L81	R:R:T128	4.42	Yes	No	0	9	8
70	R:R:L129	R:R:L81	5.54	No	Yes	2	8	9
71	R:R:L81	R:R:N317	9.61	Yes	No	2	9	9
72	R:R:L81	R:R:Y321	4.69	Yes	Yes	2	9	9
73	R:R:F82	R:R:N322	7.25	Yes	No	0	9	7
74	R:R:C83	R:R:W163	3.92	No	Yes	0	5	9
75	R:R:D85	R:R:S314	8.83	Yes	No	0	9	9
76	R:R:D85	R:R:N317	12.12	Yes	No	2	9	9
77	R:R:L87	R:R:S90	6.01	No	No	0	6	4
78	R:R:L87	R:R:S121	4.5	No	No	0	6	8
79	R:R:F88	R:R:S121	9.25	Yes	No	0	7	8
80	R:R:F88	R:R:T310	5.19	Yes	No	0	7	8
81	R:R:F311	R:R:F88	7.5	Yes	Yes	0	7	7
82	R:R:I92	R:R:P93	5.08	Yes	No	0	7	9
83	R:R:F311	R:R:I92	7.54	Yes	Yes	0	7	7
84	R:R:L106	R:R:L94	4.15	Yes	No	0	6	5
85	R:R:L114	R:R:L94	8.3	No	No	0	6	5
86	R:R:L114	R:R:V95	4.47	No	No	0	6	6
87	R:R:L96	R:R:W100	4.56	Yes	No	4	6	5
88	R:R:V98	R:R:W104	7.36	No	Yes	0	5	9
89	R:R:F304	R:R:R99	24.59	Yes	No	3	4	4
90	R:R:L105	R:R:T101	10.32	No	No	0	4	4
91	R:R:L106	R:R:W104	11.39	Yes	Yes	1	6	9
92	R:R:A110	R:R:W104	3.89	No	Yes	1	5	9
93	R:R:C111	R:R:W104	11.75	No	Yes	1	9	9
94	R:R:V179	R:R:W104	3.68	Yes	Yes	1	5	9
95	R:R:C194	R:R:W104	11.75	Yes	Yes	1	9	9
96	R:R:A110	R:R:L106	4.73	No	Yes	1	5	6
97	R:R:G107	R:R:P108	4.06	No	No	0	8	3
98	R:R:C111	R:R:F177	6.98	No	Yes	1	9	5
99	R:R:C111	R:R:C194	7.28	No	Yes	1	9	9
100	R:R:L113	R:R:V117	4.47	No	No	0	5	4
101	R:R:F115	R:R:M118	7.46	Yes	Yes	1	5	7
102	R:R:F115	R:R:L173	7.31	Yes	Yes	1	5	5
103	R:R:F115	R:R:F177	18.22	Yes	Yes	1	5	5
104	R:R:C174	R:R:Y116	9.41	No	No	0	4	5
105	R:R:F311	R:R:M118	3.73	Yes	Yes	0	7	7
106	R:R:L173	R:R:T119	5.9	Yes	Yes	1	5	5
107	R:R:F211	R:R:T119	3.89	Yes	Yes	1	5	5
108	R:R:L120	R:R:W163	5.69	No	Yes	0	5	9
109	R:R:L120	R:R:S166	4.5	No	No	0	5	8
110	R:R:G122	R:R:W277	4.22	No	Yes	0	7	9
111	R:R:F211	R:R:S123	5.28	Yes	No	1	5	6
112	R:R:N215	R:R:S123	8.94	Yes	No	1	6	6
113	R:R:V124	R:R:W163	14.71	No	Yes	0	7	9
114	R:R:S166	R:R:V124	6.46	No	No	0	8	7
115	R:R:T125	R:R:W277	4.85	No	Yes	0	9	9
116	R:R:F273	R:R:I126	5.02	Yes	No	0	9	8
117	R:R:I126	R:R:W277	16.44	No	Yes	0	8	9
118	R:R:L127	R:R:N215	8.24	No	Yes	0	6	6
119	R:R:F273	R:R:L129	3.65	Yes	No	0	9	8
120	R:R:L129	R:R:Y321	8.21	No	Yes	2	8	9
121	R:R:A130	R:R:P219	3.74	No	No	0	7	9
122	R:R:R136	R:R:V132	6.54	Yes	No	2	9	8
123	R:R:V132	R:R:Y321	3.79	No	Yes	2	8	9
124	R:R:I223	R:R:S133	9.29	No	No	0	8	8
125	R:R:S133	R:R:S226	4.89	No	No	2	8	5
126	R:R:S133	R:R:Y227	12.72	No	Yes	2	8	9
127	R:R:R136	R:R:Y227	5.14	Yes	Yes	2	9	9
128	R:R:R136	R:R:Y321	6.17	Yes	Yes	2	9	9
129	R:R:M137	R:R:S226	6.13	Yes	No	0	8	5
130	R:R:K229	R:R:M137	5.76	No	Yes	0	5	8
131	R:R:I230	R:R:M137	4.37	No	Yes	0	8	8
132	R:R:H142	R:R:V138	6.92	No	No	0	5	4
133	R:R:H142	R:R:V141	12.45	No	No	0	5	6
134	R:R:I233	R:R:V141	7.68	No	No	0	5	6
135	R:R:P172	R:R:W198	5.4	No	Yes	1	8	7
136	R:R:P172	R:R:W207	12.16	No	Yes	1	8	6
137	R:R:L173	R:R:L196	5.54	Yes	Yes	1	5	5
138	R:R:F176	R:R:V175	7.87	Yes	No	0	5	4
139	R:R:F176	R:R:R178	7.48	Yes	No	0	5	4
140	R:R:F176	R:R:W198	11.02	Yes	Yes	0	5	7
141	R:R:F176	R:R:P199	7.22	Yes	No	0	5	6
142	R:R:C194	R:R:F177	5.59	Yes	Yes	1	9	5
143	R:R:F177	R:R:L196	8.53	Yes	Yes	1	5	5
144	R:R:I197	R:R:R178	7.52	No	No	0	4	4
145	R:R:C194	R:R:V179	5.12	Yes	Yes	1	9	5
146	R:R:Q182	R:R:R183	8.18	No	No	0	2	3
147	R:R:I193	R:R:Q182	8.23	No	No	0	4	2
148	R:R:L196	R:R:W198	10.25	Yes	Yes	1	5	7
149	R:R:E204	R:R:W198	11.99	Yes	Yes	1	5	7
150	R:R:W198	R:R:W207	14.99	Yes	Yes	1	7	6
151	R:R:P202	R:R:T200	5.25	No	No	0	3	3
152	R:R:E204	R:R:I201	4.1	Yes	Yes	1	5	4
153	R:R:I201	R:R:N291	7.08	Yes	No	1	4	2
154	R:R:F292	R:R:I201	3.77	No	Yes	0	1	4
155	R:R:G203	R:R:S206	3.71	No	No	0	3	4
156	R:R:E204	R:R:L288	5.3	Yes	No	0	5	4
157	R:R:E204	R:R:N291	6.57	Yes	No	1	5	2
158	R:R:F292	R:R:I205	3.77	No	No	0	1	4
159	R:R:D208	R:R:W207	7.82	Yes	Yes	1	5	6
160	R:R:F211	R:R:W207	11.02	Yes	Yes	1	5	6
161	R:R:D208	R:R:I284	5.6	Yes	No	1	5	5
162	R:R:D208	R:R:L288	16.29	Yes	No	0	5	4
163	R:R:L214	R:R:S210	6.01	No	No	0	4	4
164	R:R:F211	R:R:N215	9.67	Yes	Yes	1	5	6
165	R:R:I281	R:R:V212	4.61	No	No	0	7	6
166	R:R:F216	R:R:L217	3.65	No	No	0	8	4
167	R:R:F216	R:R:I281	18.84	No	No	0	8	7
168	R:R:F273	R:R:G220	4.52	Yes	No	0	9	6
169	R:R:F273	R:R:I223	7.54	Yes	No	0	9	8
170	R:R:S226	R:R:Y227	6.36	No	Yes	2	5	9
171	R:R:L269	R:R:Y227	9.38	No	Yes	0	8	9
172	R:R:M270	R:R:Y227	5.99	No	Yes	0	8	9
173	R:R:K235	R:R:L231	5.64	No	No	0	5	6
174	R:R:F263	R:R:L231	7.31	No	No	0	7	6
175	R:R:L231	R:R:L266	9.69	No	No	0	6	8
176	R:R:L262	R:R:T234	4.42	No	No	0	8	8
177	R:R:D259	R:R:K235	9.68	No	No	0	7	5
178	R:R:K239	R:R:V243	4.55	No	No	0	5	2
179	R:R:L245	R:R:R240	3.64	No	No	0	3	3
180	R:R:Q252	R:R:T242	11.34	No	No	0	2	4
181	R:R:V255	R:R:Y247	3.79	No	Yes	0	5	4
182	R:R:H251	R:R:S248	12.55	No	No	0	2	6
183	R:R:E249	R:R:I253	4.1	No	No	0	4	3
184	R:R:H251	R:R:S250	4.18	No	No	0	2	5
185	R:R:Q252	R:R:S256	4.33	No	No	0	2	4
186	R:R:Q257	R:R:Q258	15.36	No	No	0	5	6
187	R:R:F260	R:R:R261	9.62	No	No	6	6	8
188	R:R:F260	R:R:R264	11.76	No	No	6	6	7
189	R:R:R261	R:R:R264	6.4	No	No	6	8	7
190	R:R:F267	R:R:V271	13.11	No	No	0	5	5
191	R:R:L320	R:R:S272	4.5	Yes	No	0	8	6
192	R:R:F273	R:R:F274	11.79	Yes	No	0	9	6
193	R:R:F309	R:R:M276	11.2	No	Yes	0	7	8
194	R:R:M276	R:R:N313	7.01	Yes	No	0	8	9
195	R:R:L316	R:R:M276	4.24	No	Yes	0	6	8
196	R:R:T310	R:R:W277	3.64	No	Yes	0	8	9
197	R:R:N313	R:R:W277	19.21	No	Yes	0	9	9
198	R:R:F309	R:R:P279	8.67	No	No	0	7	9
199	R:R:I280	R:R:T310	12.16	No	No	0	6	8
200	R:R:T283	R:R:V306	7.93	No	No	0	5	6
201	R:R:F303	R:R:I287	3.77	Yes	No	1	4	5
202	R:R:L296	R:R:Q290	13.31	No	No	7	5	4
203	R:R:I298	R:R:Q290	5.49	Yes	No	7	3	4
204	R:R:I298	R:R:L296	5.71	Yes	No	7	3	5
205	R:R:F303	R:R:V307	5.24	Yes	No	1	4	5
206	R:R:F304	R:R:W305	10.02	Yes	No	0	4	4
207	R:R:F311	R:R:V307	3.93	Yes	No	0	7	5
208	R:R:L325	R:R:N322	6.87	No	No	0	8	7
209	R:R:M323	R:R:R327	3.72	No	No	0	5	8
210	R:R:P26	R:R:S29	3.56	No	No	0	5	9
211	R:R:P108	R:R:V179	3.53	No	Yes	0	3	5
212	R:R:P219	R:R:V218	3.53	No	No	0	9	5
213	R:R:E135	R:R:R136	3.49	No	Yes	0	8	9
214	R:R:G57	R:R:L56	3.42	No	No	0	9	4
215	R:R:I126	R:R:P219	3.39	No	No	0	8	9
216	R:R:I201	R:R:P202	3.39	Yes	No	0	4	3
217	R:R:A170	R:R:T119	3.36	No	Yes	0	7	5
218	R:R:H251	R:R:Y247	3.27	No	Yes	0	2	4
219	R:R:A103	R:R:I191	3.25	No	No	0	5	4
220	R:R:S244	R:R:V243	3.23	No	No	0	5	2
221	R:R:A91	R:R:M118	3.22	No	Yes	0	6	7
222	R:R:R264	R:R:R327	3.2	No	No	0	7	8
223	R:R:C139	R:R:L143	3.17	No	No	0	8	8
224	R:R:I197	R:R:V180	3.07	No	No	0	4	4
225	R:R:M270	R:R:V224	3.04	No	No	0	8	5
226	R:R:I280	R:R:T283	3.04	No	No	0	6	5
227	R:R:G33	R:R:R36	3	No	No	0	3	4
228	R:R:L96	R:R:V48	2.98	Yes	No	0	6	4
229	R:R:L55	R:R:V59	2.98	No	No	0	5	3
230	R:R:L143	R:R:V138	2.98	No	No	0	8	4
231	R:R:I275	R:R:M276	2.92	No	Yes	0	5	8
232	R:R:P150	R:R:R155	2.88	No	No	0	6	6
233	R:R:I162	R:R:L127	2.85	No	No	0	7	6
234	R:R:I162	R:R:L158	2.85	No	No	0	7	5
235	R:R:I282	R:R:L285	2.85	No	No	0	5	6
236	R:R:I289	R:R:L286	2.85	No	No	0	4	5
237	R:R:I298	R:R:L286	2.85	Yes	No	0	3	5
238	R:R:I289	R:R:L296	2.85	No	No	0	4	5
239	R:R:L134	R:R:M137	2.83	No	Yes	0	5	8
240	R:R:H35	R:R:V38	2.77	No	No	0	3	3
241	R:R:L47	R:R:L96	2.77	No	Yes	0	6	6
242	R:R:A75	R:R:R155	2.77	No	No	0	8	6
243	R:R:L159	R:R:L77	2.77	No	No	0	7	7
244	R:R:A169	R:R:F211	2.77	No	Yes	0	5	5
245	R:R:L262	R:R:L266	2.77	No	No	0	8	8
246	R:R:L268	R:R:L320	2.77	No	Yes	0	6	8
247	R:R:L269	R:R:L320	2.77	No	Yes	0	8	8
248	R:R:D295	R:R:K293	2.77	No	No	0	3	1
249	R:R:L316	R:R:L320	2.77	No	Yes	0	6	8
250	R:R:A170	R:R:Y116	2.67	No	No	0	7	5
251	R:R:R238	R:R:S256	2.64	No	No	0	4	4
252	R:R:R240	R:R:S244	2.64	No	No	0	3	5
253	R:R:H142	R:R:M137	2.63	No	Yes	0	5	8
254	R:R:F82	R:R:V65	2.62	Yes	No	0	9	7
255	R:R:D30	R:R:E102	2.6	Yes	No	0	6	4
256	R:R:A308	R:R:W305	2.59	No	No	0	4	4
257	R:R:T242	R:R:Y247	2.5	No	Yes	0	4	4
258	R:R:S301	R:R:W299	2.47	No	No	0	2	4
259	R:R:V46	R:R:W305	2.45	No	No	0	6	4
260	R:R:L77	R:R:R155	2.43	No	No	0	7	6
261	R:R:L171	R:R:Y116	2.34	No	No	0	5	5
262	R:R:L214	R:R:Y165	2.34	No	No	0	4	4
263	R:R:Q258	R:R:R238	2.34	No	No	0	6	4
264	R:R:L241	R:R:Y247	2.34	No	Yes	0	5	4
265	R:R:N215	R:R:Y165	2.33	Yes	No	0	6	4
266	R:R:H112	R:R:R178	2.26	No	No	0	7	4
267	R:R:F263	R:R:F267	2.14	No	No	0	7	5
268	R:R:R67	R:R:R68	2.13	No	Yes	0	6	6
269	R:R:G203	R:R:P202	2.03	No	No	0	3	3
270	R:R:C60	R:R:G57	1.96	No	No	0	6	9
271	R:R:A154	R:R:G151	1.95	No	No	0	5	7
272	R:R:A167	R:R:G164	1.95	No	No	0	3	4
273	R:R:P279	R:R:S278	1.78	No	No	0	9	7
274	R:R:P181	R:R:V180	1.77	No	No	0	2	4
275	R:R:G33	R:R:K32	1.74	No	No	0	3	3
276	R:R:A315	R:R:S54	1.71	No	No	0	6	8
277	R:R:A315	R:R:V53	1.7	No	No	0	6	5
278	R:R:A84	R:R:V124	1.7	No	No	0	8	7
279	R:R:A91	R:R:V117	1.7	No	No	0	6	4
280	R:R:A130	R:R:V222	1.7	No	No	0	7	6
281	R:R:A312	R:R:I50	1.62	No	No	0	5	7
282	R:R:A131	R:R:I162	1.62	No	No	0	7	7
283	R:R:S192	R:R:V179	1.62	No	Yes	0	3	5
284	R:R:T213	R:R:V209	1.59	No	No	0	5	4
285	R:R:T213	R:R:V212	1.59	No	No	0	5	6
286	R:R:A40	R:R:L39	1.58	No	No	0	5	4
287	R:R:A167	R:R:L120	1.58	No	No	0	3	5
288	R:R:T44	R:R:T45	1.57	No	No	0	6	4
289	R:R:I253	R:R:S256	1.55	No	No	0	3	4
290	R:R:I140	R:R:V141	1.54	No	No	0	8	6
291	R:R:I230	R:R:T234	1.52	No	No	0	8	8
292	R:R:G146	R:R:R145	1.5	No	No	0	6	5
293	R:R:L49	R:R:V53	1.49	No	No	0	4	5
294	R:R:L64	R:R:V63	1.49	No	No	0	7	4
295	R:R:L79	R:R:V65	1.49	No	No	0	5	7
296	R:R:L285	R:R:V212	1.49	No	No	0	6	6
297	R:R:L221	R:R:V222	1.49	No	No	0	2	6
298	R:R:D30	R:R:S301	1.47	Yes	No	0	6	2
299	R:R:I191	R:R:I193	1.47	No	No	0	4	4
300	R:R:I225	R:R:L221	1.43	No	No	0	4	2
301	R:R:I298	R:R:L302	1.43	Yes	No	0	3	5
302	R:R:A73	R:R:R68	1.38	No	Yes	0	6	6
303	R:R:L105	R:R:L106	1.38	No	Yes	0	4	6
304	R:R:L241	R:R:L245	1.38	No	No	0	5	3
305	R:R:R238	R:R:S237	1.32	No	No	0	4	6
306	R:R:A41	R:R:W100	1.3	No	No	0	3	5
307	R:R:F311	R:R:I50	1.26	Yes	No	0	7	7
308	R:R:N328	R:R:R327	1.21	No	No	0	6	8
309	R:R:L302	R:R:W299	1.14	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.18467	15	1	0
2	R:R:F25	6.456	5	1	5
3	R:R:F27	7.685	4	1	5
4	R:R:F28	8.46	4	1	8
5	R:R:D30	5.7975	4	0	6
6	R:R:N58	8.63	4	0	9
7	R:R:R68	2.6975	4	0	6
8	R:R:L81	5.666	5	2	9
9	R:R:F82	5.72667	6	0	9
10	R:R:D85	9.285	4	2	9
11	R:R:F88	6.51	4	0	7
12	R:R:I92	6.865	4	0	7
13	R:R:L96	4.0525	4	4	6
14	R:R:W104	8.30333	6	1	9
15	R:R:L106	5.4125	4	1	6
16	R:R:F115	10.2683	6	1	5
17	R:R:M118	5.98	4	1	7
18	R:R:T119	6.0125	4	1	5
19	R:R:R136	5.335	4	2	9
20	R:R:M137	4.344	5	0	8
21	R:R:W163	7.775	4	0	9
22	R:R:L173	5.6175	4	1	5
23	R:R:F176	8.3975	4	0	5
24	R:R:F177	9.364	5	1	5
25	R:R:V179	3.4875	4	1	5
26	R:R:C194	7.435	4	1	9
27	R:R:L196	6.826	5	1	5
28	R:R:W198	10.73	5	1	7
29	R:R:I201	4.585	4	1	4
30	R:R:E204	6.484	5	1	5
31	R:R:W207	11.4975	4	1	6
32	R:R:D208	9.2525	4	1	5
33	R:R:F211	6.94	6	1	5
34	R:R:N215	6.574	5	1	6
35	R:R:Y227	7.918	5	2	9
36	R:R:Y247	2.975	4	0	4
37	R:R:F273	6.504	5	0	9
38	R:R:M276	6.3425	4	0	8
39	R:R:W277	9.20833	6	0	9
40	R:R:I298	3.87	4	7	3
41	R:R:F303	6.005	4	1	4
42	R:R:F304	13.09	4	3	4
43	R:R:F311	4.792	5	0	7
44	R:R:L320	3.2025	4	0	8
45	R:R:Y321	5.715	4	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L196	31.5021	3.72	Yes	Yes	1	0	5
2	R:R:L196	R:R:W198	20.2897	10.25	Yes	Yes	1	5	7
3	R:R:F176	R:R:W198	28.7899	11.02	Yes	Yes	0	5	7
4	R:R:F176	R:R:R178	20.2724	7.48	Yes	No	0	5	4
5	R:R:I197	R:R:R178	14.5363	7.52	No	No	0	4	4
6	L:L:?1	R:R:E204	29.2919	4.46	Yes	Yes	1	0	5
7	R:R:E204	R:R:W198	15.3731	11.99	Yes	Yes	1	5	7
8	L:L:?1	R:R:I287	24.8427	9.6	Yes	No	1	0	5
9	R:R:F25	R:R:I287	21.8709	5.02	Yes	No	1	5	5
10	R:R:F25	R:R:P26	11.6741	5.78	Yes	No	0	5	5
11	R:R:F25	R:R:P300	21.4784	4.33	Yes	No	0	5	4
12	R:R:F177	R:R:L196	19.9377	8.53	Yes	Yes	1	5	5
13	L:L:?1	R:R:F115	22.5172	11.47	Yes	Yes	1	0	5
14	L:L:?1	R:R:F88	25.1486	4.1	Yes	Yes	0	0	7
15	R:R:F311	R:R:F88	27.9762	7.5	Yes	Yes	0	7	7
16	L:L:?1	R:R:M118	23.3597	9.51	Yes	Yes	1	0	7
17	R:R:F311	R:R:M118	23.2616	3.73	Yes	Yes	0	7	7
18	R:R:P26	R:R:S29	10.2545	3.56	No	No	0	5	9
19	R:R:D30	R:R:P300	20.4166	4.83	Yes	No	0	6	4
20	R:R:F311	R:R:I92	46.3097	7.54	Yes	Yes	0	7	7
21	R:R:I92	R:R:L47	35.0799	8.56	Yes	No	0	7	6
22	R:R:F304	R:R:L47	19.5626	6.09	Yes	No	0	4	6
23	R:R:L47	R:R:L96	15.5404	2.77	No	Yes	0	6	6
24	R:R:F51	R:R:I92	23.5617	6.28	No	Yes	0	6	7
25	R:R:F51	R:R:I89	18.8528	3.77	No	No	5	6	6
26	R:R:I89	R:R:S54	18.7258	9.29	No	No	0	6	8
27	R:R:S314	R:R:S54	14.871	4.89	No	No	0	9	8
28	L:L:?1	R:R:W277	100	6.89	Yes	Yes	0	0	9
29	R:R:I126	R:R:W277	95.0372	16.44	No	Yes	0	8	9
30	R:R:F273	R:R:I126	88.2913	5.02	Yes	No	0	9	8
31	R:R:F273	R:R:L129	50.4184	3.65	Yes	No	0	9	8
32	R:R:L129	R:R:L81	44.9305	5.54	No	Yes	2	8	9
33	R:R:D85	R:R:L81	34.8895	4.07	Yes	Yes	2	9	9
34	R:R:D85	R:R:S314	14.4786	8.83	Yes	No	0	9	9
35	R:R:D85	R:R:N58	33.718	12.12	Yes	Yes	0	9	9
36	R:R:F82	R:R:N58	24.5773	3.62	Yes	Yes	0	9	9
37	R:R:F82	R:R:N322	13.388	7.25	Yes	No	0	9	7
38	R:R:L325	R:R:N322	11.7433	6.87	No	No	0	8	7
39	R:R:L325	R:R:R68	10.0871	3.64	No	Yes	0	8	6
40	R:R:L81	R:R:T128	29.39	4.42	Yes	No	0	9	8
41	R:R:N80	R:R:T128	27.855	10.24	No	No	0	9	8
42	R:R:L159	R:R:N80	11.8703	9.61	No	No	0	7	9
43	R:R:L159	R:R:L77	10.2083	2.77	No	No	0	7	7
44	R:R:N80	R:R:W163	15.1596	6.78	No	Yes	0	9	9
45	R:R:F88	R:R:T310	10.97	5.19	Yes	No	0	7	8
46	R:R:T310	R:R:W277	12.4127	3.64	No	Yes	0	8	9
47	R:R:F115	R:R:F177	20.6244	18.22	Yes	Yes	1	5	5
48	R:R:C111	R:R:F177	16.1406	6.98	No	Yes	1	9	5
49	R:R:C111	R:R:W104	13.9016	11.75	No	Yes	1	9	9
50	R:R:L106	R:R:W104	14.1208	11.39	Yes	Yes	1	6	9
51	R:R:C194	R:R:F177	25.3737	5.59	Yes	Yes	1	9	5
52	R:R:C194	R:R:W104	13.8785	11.75	Yes	Yes	1	9	9
53	L:L:?1	R:R:N215	15.3154	3.69	Yes	Yes	1	0	6
54	R:R:I126	R:R:P219	11.5587	3.39	No	No	0	8	9
55	R:R:R136	R:R:Y321	12.3146	6.17	Yes	Yes	2	9	9
56	R:R:F273	R:R:I223	36.5803	7.54	Yes	No	0	9	8
57	R:R:I223	R:R:S133	35.0338	9.29	No	No	0	8	8
58	R:R:S133	R:R:S226	29.1592	4.89	No	No	2	8	5
59	R:R:M137	R:R:S226	35.934	6.13	Yes	No	0	8	5
60	R:R:I230	R:R:M137	18.5412	4.37	No	Yes	0	8	8
61	R:R:H142	R:R:M137	13.0706	2.63	No	Yes	0	5	8
62	R:R:E204	R:R:I201	12.6782	4.1	Yes	Yes	1	5	4
63	L:L:?1	R:R:I281	14.2132	4.8	Yes	No	0	0	7
64	R:R:N313	R:R:W277	17.9295	19.21	No	Yes	0	9	9
65	R:R:M276	R:R:N313	16.1925	7.01	Yes	No	0	8	9
66	R:R:I230	R:R:T234	16.7292	1.52	No	No	0	8	8
67	R:R:L262	R:R:T234	14.9056	4.42	No	No	0	8	8
68	R:R:L262	R:R:L266	13.1629	2.77	No	No	0	8	8
69	R:R:L231	R:R:L266	11.3163	9.69	No	No	0	6	8
70	R:R:D30	R:R:S301	12.9263	1.47	Yes	No	0	6	2
71	R:R:S301	R:R:W299	11.5356	2.47	No	No	0	2	4
72	R:R:L302	R:R:W299	10.1333	1.14	No	No	0	5	4
73	R:R:L81	R:R:Y321	10.6007	4.69	Yes	Yes	2	9	9
74	R:R:R136	R:R:Y227	10.041	5.14	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F88	4.1	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F115	11.47	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M118	9.51	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T119	10.9	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L173	3.72	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L196	3.72	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:E204	4.46	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:D208	7.3	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F211	9.01	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N215	3.69	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W277	6.89	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:I280	18.24	1	Yes	No	0	6	0	1
L:L:?1	R:R:I281	4.8	1	Yes	No	0	7	0	1
L:L:?1	R:R:I284	15.36	1	Yes	No	0	5	0	1
L:L:?1	R:R:I287	9.6	1	Yes	No	0	5	0	1
R:R:F25	R:R:F27	7.5	1	Yes	Yes	5	5	2	2
R:R:F25	R:R:I287	5.02	1	Yes	No	5	5	2	1
R:R:F25	R:R:F303	9.65	1	Yes	Yes	5	4	2	2
R:R:F115	R:R:F27	9.65	1	Yes	Yes	5	5	1	2
R:R:F177	R:R:F27	7.5	1	Yes	Yes	5	5	2	2
R:R:F27	R:R:L196	6.09	1	Yes	Yes	5	5	2	1
R:R:F115	R:R:F28	7.5	1	Yes	Yes	5	8	1	2
R:R:F28	R:R:F303	5.36	1	Yes	Yes	8	4	2	2
R:R:F88	R:R:S121	9.25	0	Yes	No	7	8	1	2
R:R:F88	R:R:T310	5.19	0	Yes	No	7	8	1	2
R:R:F311	R:R:F88	7.5	0	Yes	Yes	7	7	2	1
R:R:F115	R:R:M118	7.46	1	Yes	Yes	5	7	1	1
R:R:F115	R:R:L173	7.31	1	Yes	Yes	5	5	1	1
R:R:F115	R:R:F177	18.22	1	Yes	Yes	5	5	1	2
R:R:F311	R:R:M118	3.73	0	Yes	Yes	7	7	2	1
R:R:L173	R:R:T119	5.9	1	Yes	Yes	5	5	1	1
R:R:F211	R:R:T119	3.89	1	Yes	Yes	5	5	1	1
R:R:G122	R:R:W277	4.22	0	No	Yes	7	9	2	1
R:R:F211	R:R:S123	5.28	1	Yes	No	5	6	1	2
R:R:N215	R:R:S123	8.94	1	Yes	No	6	6	1	2
R:R:T125	R:R:W277	4.85	0	No	Yes	9	9	2	1
R:R:I126	R:R:W277	16.44	0	No	Yes	8	9	2	1
R:R:L127	R:R:N215	8.24	0	No	Yes	6	6	2	1
R:R:L173	R:R:L196	5.54	1	Yes	Yes	5	5	1	1
R:R:F177	R:R:L196	8.53	1	Yes	Yes	5	5	2	1
R:R:L196	R:R:W198	10.25	1	Yes	Yes	5	7	1	2
R:R:E204	R:R:W198	11.99	1	Yes	Yes	5	7	1	2
R:R:W198	R:R:W207	14.99	1	Yes	Yes	7	6	2	2
R:R:E204	R:R:I201	4.1	1	Yes	Yes	5	4	1	2
R:R:I201	R:R:N291	7.08	1	Yes	No	4	2	2	2
R:R:E204	R:R:L288	5.3	1	Yes	No	5	4	1	2
R:R:E204	R:R:N291	6.57	1	Yes	No	5	2	1	2
R:R:D208	R:R:W207	7.82	1	Yes	Yes	5	6	1	2
R:R:F211	R:R:W207	11.02	1	Yes	Yes	5	6	1	2
R:R:D208	R:R:I284	5.6	1	Yes	No	5	5	1	1
R:R:D208	R:R:L288	16.29	1	Yes	No	5	4	1	2
R:R:F211	R:R:N215	9.67	1	Yes	Yes	5	6	1	1
R:R:I281	R:R:V212	4.61	0	No	No	7	6	1	2
R:R:F216	R:R:I281	18.84	0	No	No	8	7	2	1
R:R:T310	R:R:W277	3.64	0	No	Yes	8	9	2	1
R:R:N313	R:R:W277	19.21	0	No	Yes	9	9	2	1
R:R:I280	R:R:T310	12.16	0	No	No	6	8	1	2
R:R:F303	R:R:I287	3.77	1	Yes	No	4	5	2	1
R:R:A170	R:R:T119	3.36	0	No	Yes	7	5	2	1
R:R:A91	R:R:M118	3.22	0	No	Yes	6	7	2	1
R:R:I280	R:R:T283	3.04	0	No	No	6	5	1	2
R:R:A169	R:R:F211	2.77	0	No	Yes	5	5	2	1
R:R:N215	R:R:Y165	2.33	1	Yes	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8T3O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.62
Number of Linked Nodes	272
Number of Links	309
Number of Hubs	45
Number of Links mediated by Hubs	165
Number of Communities	7
Number of Nodes involved in Communities	55
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	42996
Length Of Smallest Path	3
Average Path Length	10.7888
Length of Longest Path	26
Minimum Path Strength	1.285
Average Path Strength	6.88065
Maximum Path Strength	19.44
Minimum Path Correlation	0.7
Average Path Correlation	0.939815
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	68.7228
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.8679
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein binding • binding • arrestin family protein binding • fatty acid binding • organic acid binding • ion binding • anion binding • lipid binding • carboxylic acid binding • monocarboxylic acid binding • small molecule binding • taste receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion • somatostatin secretion • negative regulation of cell communication • cell communication • negative regulation of peptide secretion • negative regulation of somatostatin secretion • peptide secretion • localization • secretion by cell • regulation of secretion by cell • negative regulation of secretion • amide transport • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of peptide hormone secretion • regulation of biological process • regulation of signaling • negative regulation of peptide hormone secretion • secretion • regulation of transport • regulation of hormone levels • regulation of peptide transport • cell-cell signaling • export from cell • establishment of localization • regulation of secretion • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • hexose transmembrane transport • carbohydrate transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • multicellular organismal process • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • ghrelin secretion • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • developmental process • regulation of osteoblast differentiation • cellular developmental process • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • cell differentiation • phospholipase C-activating G protein-coupled receptor signaling pathway • fat cell differentiation • positive regulation of brown fat cell differentiation • positive regulation of fat cell differentiation • regulation of brown fat cell differentiation • brown fat cell differentiation • regulation of fat cell differentiation • glucagon secretion • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • regulation of glucagon secretion • positive regulation of peptide secretion • positive regulation of glucagon secretion • positive regulation of peptide hormone secretion • positive regulation of transport • white fat cell differentiation • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular organelle • intracellular anatomical structure • intracellular membrane-bounded organelle • intracellular vesicle • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular organelle • intracellular anatomical structure • intracellular membrane-bounded organelle • intracellular vesicle • cytoplasmic vesicle • cytoplasm • vesicle • endocytic vesicle • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • endosome membrane • endosome • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • intracellular membraneless organelle • ciliary basal body • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YN9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YN9
Name	3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid
Synonyms
Identifier
Formula	C23 H21 F O3
Molecular Weight	364.409
SMILES
PubChem	57522038
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	0
Total Bonds	50
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5NUL3
Sequence	>8T3O_nogp_Chain_R R T R F P F F S D V K G D H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R R R R G A T A C L V L N L F C A D L L F I S A I P L V L A V R W T E A W L L G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H L Q R G P G R R A R A V L L A L I W G Y S A V A A L P L C V F F R V V P Q R I S I C T L I W P T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L A Y S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q D L V I W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IYS	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP	chim(NtGi1L-Gq)/β1/γ2	2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8IYS (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP		2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8T3O	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3O (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3Q	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3Q (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8G59	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(Gi1-CtGq)/β1/γ2	2.64	2023-03-08	doi.org/10.1126/science.add6220
	8G59 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		2.64	2023-03-08	doi.org/10.1126/science.add6220
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID6	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-	Gi1/β1/γ2	2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID6 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-		2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID8	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID8 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-		3	2023-03-15	doi.org/10.1126/science.add6220

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