psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R22	3.69	Yes	No	0	0	5
2	L:L:?1	R:R:M118	7.52	Yes	No	0	0	7
3	L:L:?1	R:R:T119	10.07	Yes	No	1	0	5
4	L:L:?1	R:R:G122	5.2	Yes	No	0	0	7
5	L:L:?1	R:R:L173	6.31	Yes	Yes	1	0	5
6	L:L:?1	R:R:L196	5.26	Yes	Yes	0	0	5
7	L:L:?1	R:R:E204	8.05	Yes	Yes	1	0	5
8	L:L:?1	R:R:D208	7.21	Yes	Yes	1	0	5
9	L:L:?1	R:R:F211	3.7	Yes	Yes	1	0	5
10	L:L:?1	R:R:W277	5.19	Yes	Yes	1	0	9
11	L:L:?1	R:R:I280	8.67	Yes	Yes	1	0	6
12	L:L:?1	R:R:I284	10.84	Yes	No	1	0	5
13	L:L:?1	R:R:I287	15.18	Yes	No	0	0	5
14	L:L:?1	R:R:N291	13.56	Yes	No	1	0	2
15	R:R:R22	R:R:R24	15.99	No	No	0	5	5
16	R:R:R24	R:R:T195	14.23	No	No	0	5	4
17	R:R:I197	R:R:R24	6.26	No	No	0	4	5
18	R:R:F25	R:R:P26	5.78	Yes	No	0	5	5
19	R:R:F25	R:R:F27	19.29	Yes	Yes	2	5	5
20	R:R:F25	R:R:I298	3.77	Yes	No	0	5	3
21	R:R:F25	R:R:F303	10.72	Yes	No	2	5	4
22	R:R:P26	R:R:P300	5.84	No	No	0	5	4
23	R:R:F115	R:R:F27	5.36	Yes	Yes	2	5	5
24	R:R:F27	R:R:L196	4.87	Yes	Yes	0	5	5
25	R:R:F27	R:R:F303	5.36	Yes	No	2	5	4
26	R:R:F28	R:R:R99	5.34	Yes	Yes	2	8	4
27	R:R:F115	R:R:F28	4.29	Yes	Yes	2	5	8
28	R:R:F28	R:R:F304	3.22	Yes	Yes	2	8	4
29	R:R:F28	R:R:V307	7.87	Yes	No	0	8	5
30	R:R:E102	R:R:S29	5.75	Yes	No	0	4	9
31	R:R:D30	R:R:R99	10.72	No	Yes	0	6	4
32	R:R:D30	R:R:P300	4.83	No	No	0	6	4
33	R:R:D30	R:R:S301	8.83	No	No	0	6	2
34	R:R:K32	R:R:V31	6.07	No	No	0	3	6
35	R:R:E102	R:R:V31	4.28	Yes	No	0	4	6
36	R:R:D34	R:R:H35	18.91	No	No	0	3	3
37	R:R:E102	R:R:R36	3.49	Yes	No	0	4	4
38	R:R:A40	R:R:W100	5.19	No	No	0	5	5
39	R:R:E43	R:R:R99	24.42	No	Yes	2	5	4
40	R:R:E43	R:R:F304	11.66	No	Yes	2	5	4
41	R:R:L96	R:R:T44	4.42	No	No	0	6	6
42	R:R:T44	R:R:W100	14.55	No	No	0	6	5
43	R:R:I92	R:R:L47	7.14	Yes	Yes	0	7	6
44	R:R:L47	R:R:L96	4.15	Yes	No	0	6	6
45	R:R:F304	R:R:L47	7.31	Yes	Yes	0	4	6
46	R:R:A312	R:R:I50	3.25	No	No	0	5	7
47	R:R:F51	R:R:L55	7.31	No	Yes	0	6	5
48	R:R:F51	R:R:I92	5.02	No	Yes	5	6	7
49	R:R:F51	R:R:P93	5.78	No	No	5	6	9
50	R:R:A315	R:R:V53	3.39	No	No	0	6	5
51	R:R:I89	R:R:S54	9.29	No	No	0	6	8
52	R:R:S314	R:R:S54	4.89	No	No	0	9	8
53	R:R:F82	R:R:N58	3.62	Yes	Yes	4	9	9
54	R:R:D85	R:R:N58	12.12	No	Yes	4	9	9
55	R:R:L86	R:R:N58	6.87	No	Yes	0	7	9
56	R:R:N58	R:R:P318	6.52	Yes	No	4	9	9
57	R:R:A61	R:R:F82	8.32	No	Yes	0	8	9
58	R:R:A66	R:R:R69	4.15	No	No	0	1	7
59	R:R:R67	R:R:R70	5.33	No	No	0	6	7
60	R:R:R67	R:R:R71	14.93	No	No	0	6	7
61	R:R:L325	R:R:R68	3.64	No	No	0	8	6
62	R:R:C76	R:R:V78	3.42	No	No	0	5	8
63	R:R:E135	R:R:L77	6.63	No	No	0	8	7
64	R:R:F82	R:R:V78	3.93	Yes	No	0	9	8
65	R:R:N80	R:R:T128	8.77	No	No	0	9	8
66	R:R:L159	R:R:N80	5.49	No	No	0	7	9
67	R:R:N80	R:R:W163	9.04	No	Yes	0	9	9
68	R:R:L81	R:R:T125	4.42	Yes	No	0	9	9
69	R:R:L81	R:R:T128	7.37	Yes	No	0	9	8
70	R:R:L129	R:R:L81	5.54	No	Yes	3	8	9
71	R:R:L81	R:R:N317	8.24	Yes	No	3	9	9
72	R:R:L81	R:R:Y321	3.52	Yes	Yes	3	9	9
73	R:R:F82	R:R:P318	8.67	Yes	No	4	9	9
74	R:R:F82	R:R:N322	4.83	Yes	No	0	9	7
75	R:R:A84	R:R:V124	5.09	No	Yes	0	8	7
76	R:R:D85	R:R:S314	10.31	No	No	0	9	9
77	R:R:D85	R:R:P318	3.22	No	No	4	9	9
78	R:R:L87	R:R:W163	4.56	No	Yes	0	6	9
79	R:R:F88	R:R:S121	10.57	No	No	0	7	8
80	R:R:F88	R:R:T310	3.89	No	No	0	7	8
81	R:R:F311	R:R:F88	6.43	Yes	No	0	7	7
82	R:R:I92	R:R:P93	5.08	Yes	No	5	7	9
83	R:R:F311	R:R:I92	6.28	Yes	Yes	0	7	7
84	R:R:L114	R:R:L94	5.54	Yes	No	0	6	5
85	R:R:L114	R:R:V95	5.96	Yes	No	0	6	6
86	R:R:T101	R:R:V98	3.17	No	No	0	4	5
87	R:R:V98	R:R:W104	24.52	No	Yes	0	5	9
88	R:R:F304	R:R:R99	31	Yes	Yes	2	4	4
89	R:R:L105	R:R:T101	7.37	No	No	0	4	4
90	R:R:L106	R:R:W104	9.11	No	Yes	0	6	9
91	R:R:C111	R:R:W104	19.59	No	Yes	2	9	9
92	R:R:L114	R:R:W104	10.25	Yes	Yes	2	6	9
93	R:R:F115	R:R:W104	7.02	Yes	Yes	2	5	9
94	R:R:C194	R:R:W104	10.45	Yes	Yes	2	9	9
95	R:R:L105	R:R:L106	5.54	No	No	0	4	6
96	R:R:G107	R:R:P108	4.06	No	No	0	8	3
97	R:R:C111	R:R:F177	6.98	No	Yes	2	9	5
98	R:R:C111	R:R:C194	5.46	No	Yes	2	9	9
99	R:R:F177	R:R:H112	15.84	Yes	No	0	5	7
100	R:R:F115	R:R:L114	8.53	Yes	Yes	2	5	6
101	R:R:F115	R:R:F177	6.43	Yes	Yes	2	5	5
102	R:R:C174	R:R:Y116	8.06	No	No	0	4	5
103	R:R:F311	R:R:M118	6.22	Yes	No	0	7	7
104	R:R:A170	R:R:T119	3.36	No	No	0	7	5
105	R:R:L173	R:R:T119	4.42	Yes	No	1	5	5
106	R:R:L120	R:R:W163	5.69	No	Yes	0	5	9
107	R:R:S121	R:R:V124	3.23	No	Yes	0	8	7
108	R:R:S123	R:R:S166	3.26	No	No	0	6	8
109	R:R:F211	R:R:S123	3.96	Yes	No	1	5	6
110	R:R:N215	R:R:S123	8.94	Yes	No	1	6	6
111	R:R:V124	R:R:W163	23.29	Yes	Yes	0	7	9
112	R:R:S166	R:R:V124	4.85	No	Yes	0	8	7
113	R:R:T125	R:R:W277	6.06	No	Yes	0	9	9
114	R:R:I126	R:R:P219	3.39	No	No	0	8	9
115	R:R:F273	R:R:I126	5.02	Yes	No	1	9	8
116	R:R:I126	R:R:W277	19.97	No	Yes	1	8	9
117	R:R:L127	R:R:N215	4.12	No	Yes	0	6	6
118	R:R:L127	R:R:P219	3.28	No	No	0	6	9
119	R:R:L129	R:R:N317	4.12	No	No	3	8	9
120	R:R:L129	R:R:Y321	7.03	No	Yes	3	8	9
121	R:R:A130	R:R:I223	3.25	No	No	0	7	8
122	R:R:R136	R:R:V132	6.54	No	No	3	9	8
123	R:R:V132	R:R:Y321	5.05	No	Yes	3	8	9
124	R:R:I223	R:R:S133	4.64	No	No	0	8	8
125	R:R:S133	R:R:Y227	11.45	No	Yes	0	8	9
126	R:R:R136	R:R:Y227	5.14	No	Yes	0	9	9
127	R:R:R136	R:R:Y321	7.2	No	Yes	3	9	9
128	R:R:M137	R:R:S226	6.13	Yes	No	0	8	5
129	R:R:K229	R:R:M137	7.2	No	Yes	0	5	8
130	R:R:I230	R:R:M137	5.83	No	Yes	0	8	8
131	R:R:R155	R:R:V138	3.92	No	No	0	6	4
132	R:R:H142	R:R:L143	7.71	No	No	0	5	8
133	R:R:L214	R:R:Y165	3.52	No	No	0	4	4
134	R:R:N215	R:R:Y165	8.14	Yes	No	0	6	4
135	R:R:L171	R:R:P172	4.93	No	No	0	5	8
136	R:R:C174	R:R:L171	4.76	No	No	0	4	5
137	R:R:P172	R:R:W198	4.05	No	Yes	1	8	7
138	R:R:P172	R:R:W207	20.27	No	Yes	1	8	6
139	R:R:L173	R:R:W198	3.42	Yes	Yes	1	5	7
140	R:R:L173	R:R:W207	7.97	Yes	Yes	1	5	6
141	R:R:C174	R:R:V175	3.42	No	No	0	4	4
142	R:R:F176	R:R:V175	7.87	No	No	0	5	4
143	R:R:F176	R:R:W198	27.06	No	Yes	0	5	7
144	R:R:F176	R:R:P199	5.78	No	No	0	5	6
145	R:R:C194	R:R:F177	6.98	Yes	Yes	2	9	5
146	R:R:F177	R:R:L196	3.65	Yes	Yes	0	5	5
147	R:R:I197	R:R:R178	15.03	No	No	0	4	4
148	R:R:C194	R:R:V179	3.42	Yes	No	0	9	5
149	R:R:P181	R:R:V180	3.53	No	No	0	2	4
150	R:R:T195	R:R:V180	3.17	No	No	0	4	4
151	R:R:I193	R:R:Q182	6.86	No	No	0	4	2
152	R:R:I191	R:R:S192	4.64	No	No	0	4	3
153	R:R:I193	R:R:T195	4.56	No	No	0	4	4
154	R:R:L196	R:R:W198	5.69	Yes	Yes	0	5	7
155	R:R:I197	R:R:P199	5.08	No	No	0	4	6
156	R:R:E204	R:R:W198	15.27	Yes	Yes	1	5	7
157	R:R:W198	R:R:W207	8.43	Yes	Yes	1	7	6
158	R:R:P202	R:R:T200	5.25	No	No	0	3	3
159	R:R:G203	R:R:T200	5.46	No	No	0	3	3
160	R:R:I201	R:R:P202	5.08	No	No	0	4	3
161	R:R:I201	R:R:N291	8.5	No	No	0	4	2
162	R:R:G203	R:R:S206	3.71	No	No	0	3	4
163	R:R:D208	R:R:E204	6.5	Yes	Yes	1	5	5
164	R:R:E204	R:R:L288	3.98	Yes	No	1	5	4
165	R:R:E204	R:R:N291	3.94	Yes	No	1	5	2
166	R:R:D208	R:R:W207	7.82	Yes	Yes	1	5	6
167	R:R:F211	R:R:W207	8.02	Yes	Yes	1	5	6
168	R:R:D208	R:R:L288	9.5	Yes	No	1	5	4
169	R:R:F211	R:R:N215	13.29	Yes	Yes	1	5	6
170	R:R:I281	R:R:V212	4.61	No	No	0	7	6
171	R:R:L217	R:R:T213	5.9	No	No	0	4	5
172	R:R:F216	R:R:I281	20.09	No	No	0	8	7
173	R:R:P219	R:R:V218	5.3	No	No	0	9	5
174	R:R:F273	R:R:G220	4.52	Yes	No	0	9	6
175	R:R:F273	R:R:I223	7.54	Yes	No	0	9	8
176	R:R:S226	R:R:Y227	6.36	No	Yes	0	5	9
177	R:R:L269	R:R:Y227	7.03	No	Yes	0	8	9
178	R:R:M270	R:R:Y227	7.18	No	Yes	0	8	9
179	R:R:K229	R:R:Q232	6.78	No	No	0	5	4
180	R:R:F263	R:R:L231	3.65	No	No	0	7	6
181	R:R:L231	R:R:L266	12.46	No	No	0	6	8
182	R:R:L262	R:R:T234	4.42	No	No	0	8	8
183	R:R:D259	R:R:K235	4.15	No	No	0	7	5
184	R:R:Q252	R:R:R238	5.84	Yes	Yes	0	2	4
185	R:R:R238	R:R:S256	3.95	Yes	No	6	4	4
186	R:R:D259	R:R:R238	15.48	No	Yes	6	7	4
187	R:R:K239	R:R:V243	4.55	No	No	0	5	2
188	R:R:Q252	R:R:T242	15.59	Yes	No	0	2	4
189	R:R:Q252	R:R:Y247	3.38	Yes	No	0	2	4
190	R:R:S248	R:R:S250	4.89	No	No	0	6	5
191	R:R:H251	R:R:S248	6.97	No	No	0	2	6
192	R:R:D259	R:R:S256	5.89	No	No	6	7	4
193	R:R:F260	R:R:R264	9.62	No	No	0	6	7
194	R:R:R261	R:R:R264	4.26	Yes	No	7	8	7
195	R:R:R261	R:R:T324	5.17	Yes	No	0	8	7
196	R:R:R261	R:R:R327	10.66	Yes	No	7	8	8
197	R:R:F263	R:R:F267	8.57	No	No	0	7	5
198	R:R:R264	R:R:R327	5.33	No	No	7	7	8
199	R:R:F267	R:R:V271	13.11	No	No	0	5	5
200	R:R:L269	R:R:L320	5.54	No	No	0	8	8
201	R:R:L320	R:R:S272	4.5	No	No	0	8	6
202	R:R:F273	R:R:F274	5.36	Yes	No	0	9	6
203	R:R:F273	R:R:W277	6.01	Yes	Yes	1	9	9
204	R:R:M276	R:R:N313	14.02	No	No	0	8	9
205	R:R:L316	R:R:M276	7.07	No	No	0	6	8
206	R:R:T310	R:R:W277	3.64	No	Yes	0	8	9
207	R:R:N313	R:R:W277	13.56	No	Yes	0	9	9
208	R:R:P279	R:R:S278	5.34	No	No	0	9	7
209	R:R:F309	R:R:P279	4.33	No	No	0	7	9
210	R:R:I280	R:R:T283	4.56	Yes	No	0	6	5
211	R:R:I280	R:R:I284	4.42	Yes	No	1	6	5
212	R:R:I280	R:R:T310	4.56	Yes	No	0	6	8
213	R:R:T283	R:R:V306	7.93	No	No	0	5	6
214	R:R:F303	R:R:I287	3.77	No	No	0	4	5
215	R:R:F292	R:R:I289	5.02	No	No	0	1	4
216	R:R:L296	R:R:Q290	5.32	No	No	0	5	4
217	R:R:I298	R:R:Q290	9.61	No	No	0	3	4
218	R:R:F292	R:R:K293	4.96	No	No	0	1	1
219	R:R:D295	R:R:K293	13.83	No	No	0	3	1
220	R:R:K293	R:R:L296	14.1	No	No	0	1	5
221	R:R:D295	R:R:Q294	9.14	No	No	0	3	1
222	R:R:F304	R:R:W305	7.02	Yes	No	0	4	4
223	R:R:F311	R:R:V307	3.93	Yes	No	0	7	5
224	R:R:N313	R:R:N317	8.17	No	No	0	9	9
225	R:R:I319	R:R:L316	4.28	No	No	0	7	6
226	R:R:M323	R:R:R327	4.96	No	No	0	5	8
227	R:R:C326	R:R:E329	6.08	No	No	0	5	6
228	R:R:I193	R:R:S29	3.1	No	No	0	4	9
229	R:R:A103	R:R:E102	3.02	No	Yes	0	5	4
230	R:R:F216	R:R:W277	3.01	No	Yes	0	8	9
231	R:R:G33	R:R:R36	3	No	No	0	3	4
232	R:R:L47	R:R:V46	2.98	Yes	No	0	6	6
233	R:R:L55	R:R:V59	2.98	Yes	No	0	5	3
234	R:R:L113	R:R:V117	2.98	No	No	0	5	4
235	R:R:L214	R:R:T213	2.95	No	No	0	4	5
236	R:R:L286	R:R:T283	2.95	No	No	0	5	5
237	R:R:I140	R:R:I230	2.94	No	No	0	8	8
238	R:R:Q252	R:R:V255	2.87	Yes	No	0	2	5
239	R:R:I162	R:R:L127	2.85	Yes	No	0	7	6
240	R:R:L268	R:R:M323	2.83	No	No	0	6	5
241	R:R:K235	R:R:L231	2.82	No	No	0	5	6
242	R:R:H35	R:R:V38	2.77	No	No	0	3	3
243	R:R:L55	R:R:L86	2.77	Yes	No	0	5	7
244	R:R:A73	R:R:R68	2.77	No	No	0	6	6
245	R:R:A75	R:R:R152	2.77	No	No	0	8	3
246	R:R:A169	R:R:F211	2.77	No	Yes	0	5	5
247	R:R:L241	R:R:L245	2.77	No	No	0	5	3
248	R:R:L262	R:R:L266	2.77	No	No	0	8	8
249	R:R:L268	R:R:L320	2.77	No	No	0	6	8
250	R:R:A167	R:R:Y116	2.67	No	No	0	3	5
251	R:R:L241	R:R:Q252	2.66	No	Yes	0	5	2
252	R:R:C83	R:R:W163	2.61	No	Yes	0	5	9
253	R:R:F309	R:R:M276	2.49	No	No	0	7	8
254	R:R:V297	R:R:W299	2.45	No	No	0	4	4
255	R:R:L79	R:R:R69	2.43	No	No	0	5	7
256	R:R:L266	R:R:Y227	2.34	No	Yes	0	8	9
257	R:R:Q257	R:R:R254	2.34	No	No	0	5	4
258	R:R:A154	R:R:G151	1.95	No	No	0	5	7
259	R:R:P181	R:R:S192	1.78	No	No	0	2	3
260	R:R:P108	R:R:V179	1.77	No	No	0	3	5
261	R:R:G33	R:R:L39	1.71	No	No	0	3	4
262	R:R:A315	R:R:S54	1.71	No	No	0	6	8
263	R:R:G57	R:R:L56	1.71	No	No	0	9	4
264	R:R:C76	R:R:V65	1.71	No	No	0	5	7
265	R:R:C139	R:R:V138	1.71	No	No	0	8	4
266	R:R:A91	R:R:V117	1.7	No	No	0	6	4
267	R:R:A130	R:R:V222	1.7	No	No	0	7	6
268	R:R:L143	R:R:P150	1.64	No	No	0	8	6
269	R:R:A131	R:R:I162	1.62	No	Yes	0	7	7
270	R:R:S228	R:R:V224	1.62	No	No	0	3	5
271	R:R:V38	R:R:V42	1.6	No	No	0	3	5
272	R:R:T44	R:R:V48	1.59	No	No	0	6	4
273	R:R:C60	R:R:L64	1.59	No	No	0	6	7
274	R:R:C76	R:R:L79	1.59	No	No	0	5	5
275	R:R:T242	R:R:V243	1.59	No	No	0	4	2
276	R:R:C326	R:R:L325	1.59	No	No	0	5	8
277	R:R:A308	R:R:L47	1.58	No	Yes	0	4	6
278	R:R:A131	R:R:L77	1.58	No	No	0	7	7
279	R:R:A110	R:R:L106	1.58	No	No	0	5	6
280	R:R:I233	R:R:V141	1.54	No	No	0	5	6
281	R:R:I205	R:R:V209	1.54	No	No	0	4	4
282	R:R:C139	R:R:E135	1.52	No	No	0	8	8
283	R:R:M137	R:R:V141	1.52	Yes	No	0	8	6
284	R:R:M270	R:R:V224	1.52	No	No	0	8	5
285	R:R:I233	R:R:T234	1.52	No	No	0	5	8
286	R:R:L87	R:R:S90	1.5	No	No	0	6	4
287	R:R:L49	R:R:V53	1.49	No	No	0	4	5
288	R:R:L62	R:R:V65	1.49	No	No	0	6	7
289	R:R:L64	R:R:V63	1.49	No	No	0	7	4
290	R:R:L143	R:R:V138	1.49	No	No	0	8	4
291	R:R:L285	R:R:V212	1.49	No	No	0	6	6
292	R:R:L302	R:R:V306	1.49	No	No	0	5	6
293	R:R:I162	R:R:L158	1.43	Yes	No	0	7	5
294	R:R:I162	R:R:L161	1.43	Yes	No	0	7	2
295	R:R:I205	R:R:L288	1.43	No	No	0	4	4
296	R:R:I282	R:R:L286	1.43	No	No	0	5	5
297	R:R:L134	R:R:M137	1.41	No	Yes	0	5	8
298	R:R:E249	R:R:T242	1.41	No	No	0	4	4
299	R:R:A312	R:R:F309	1.39	No	No	0	5	7
300	R:R:L55	R:R:L56	1.38	Yes	No	0	5	4
301	R:R:A66	R:R:R70	1.38	No	No	0	1	7
302	R:R:L325	R:R:N322	1.37	No	No	0	8	7
303	R:R:P300	R:R:W299	1.35	No	No	0	4	4
304	R:R:R238	R:R:S237	1.32	Yes	No	0	4	6
305	R:R:R240	R:R:S244	1.32	No	No	0	3	5
306	R:R:E329	R:R:N328	1.31	No	No	0	6	6
307	R:R:R261	R:R:T265	1.29	Yes	No	0	8	8
308	R:R:S210	R:R:W207	1.24	No	Yes	0	4	6
309	R:R:V42	R:R:W305	1.23	No	No	0	5	4
310	R:R:L241	R:R:R240	1.21	No	No	0	5	3
311	R:R:Q258	R:R:R261	1.17	No	Yes	0	6	8
312	R:R:H251	R:R:Y247	1.09	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.88929	14	1	0
2	R:R:F25	9.89	4	2	5
3	R:R:F27	8.72	4	2	5
4	R:R:F28	5.18	4	2	8
5	R:R:L47	4.632	5	0	6
6	R:R:L55	3.61	4	0	5
7	R:R:N58	7.2825	4	4	9
8	R:R:L81	5.818	5	3	9
9	R:R:F82	5.874	5	4	9
10	R:R:I92	5.88	4	5	7
11	R:R:R99	17.87	4	2	4
12	R:R:E102	4.135	4	0	4
13	R:R:W104	13.49	6	2	9
14	R:R:L114	7.57	4	2	6
15	R:R:F115	6.326	5	2	5
16	R:R:V124	9.115	4	0	7
17	R:R:M137	4.418	5	0	8
18	R:R:I162	1.8325	4	0	7
19	R:R:W163	9.038	5	0	9
20	R:R:L173	5.53	4	1	5
21	R:R:F177	7.976	5	2	5
22	R:R:C194	6.5775	4	2	9
23	R:R:L196	4.8675	4	0	5
24	R:R:W198	10.6533	6	1	7
25	R:R:E204	7.548	5	1	5
26	R:R:W207	8.95833	6	1	6
27	R:R:D208	7.7575	4	1	5
28	R:R:F211	6.348	5	1	5
29	R:R:N215	8.6225	4	1	6
30	R:R:Y227	6.58333	6	0	9
31	R:R:R238	6.6475	4	6	4
32	R:R:Q252	6.068	5	0	2
33	R:R:R261	4.51	5	7	8
34	R:R:F273	5.69	5	1	9
35	R:R:W277	8.20571	7	1	9
36	R:R:I280	5.5525	4	1	6
37	R:R:F304	12.042	5	2	4
38	R:R:F311	5.715	4	0	7
39	R:R:Y321	5.7	4	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R22	27.2364	3.69	Yes	No	0	0	5
2	R:R:R22	R:R:R24	25.8563	15.99	No	No	0	5	5
3	R:R:R24	R:R:T195	21.9599	14.23	No	No	0	5	4
4	L:L:?1	R:R:L196	63.2879	5.26	Yes	Yes	0	0	5
5	R:R:F27	R:R:L196	31.1832	4.87	Yes	Yes	0	5	5
6	R:R:F25	R:R:F27	18.4255	19.29	Yes	Yes	2	5	5
7	L:L:?1	R:R:I287	13.7718	15.18	Yes	No	0	0	5
8	R:R:F303	R:R:I287	12.7199	3.77	No	No	0	4	5
9	R:R:F25	R:R:F303	11.8783	10.72	Yes	No	2	5	4
10	R:R:F25	R:R:I298	19.2165	3.77	Yes	No	0	5	3
11	R:R:F115	R:R:F27	22.0736	5.36	Yes	Yes	2	5	5
12	R:R:F115	R:R:F28	32.0289	4.29	Yes	Yes	2	5	8
13	L:L:?1	R:R:M118	58.9371	7.52	Yes	No	0	0	7
14	R:R:F311	R:R:M118	58.226	6.22	Yes	No	0	7	7
15	R:R:F311	R:R:V307	20.5083	3.93	Yes	No	0	7	5
16	R:R:F28	R:R:V307	19.3175	7.87	Yes	No	0	8	5
17	R:R:F28	R:R:R99	11.1756	5.34	Yes	Yes	2	8	4
18	R:R:F177	R:R:L196	32.7148	3.65	Yes	Yes	0	5	5
19	R:R:F115	R:R:F177	19.9487	6.43	Yes	Yes	2	5	5
20	R:R:F28	R:R:F304	25.8647	3.22	Yes	Yes	2	8	4
21	R:R:I193	R:R:T195	14.8489	4.56	No	No	0	4	4
22	R:R:I193	R:R:S29	11.9456	3.1	No	No	0	4	9
23	R:R:E102	R:R:S29	10.4814	5.75	Yes	No	0	4	9
24	R:R:F311	R:R:I92	75.4818	6.28	Yes	Yes	0	7	7
25	R:R:I92	R:R:L47	26.5632	7.14	Yes	Yes	0	7	6
26	R:R:F304	R:R:L47	17.1169	7.31	Yes	Yes	0	4	6
27	R:R:F304	R:R:W305	20.0034	7.02	Yes	No	0	4	4
28	R:R:V42	R:R:W305	16.0187	1.23	No	No	0	5	4
29	R:R:V38	R:R:V42	12.0256	1.6	No	No	0	3	5
30	L:L:?1	R:R:W277	100	5.19	Yes	Yes	1	0	9
31	R:R:N313	R:R:W277	19.5195	13.56	No	Yes	0	9	9
32	R:R:M276	R:R:N313	18.6443	14.02	No	No	0	8	9
33	R:R:F309	R:R:M276	11.7142	2.49	No	No	0	7	8
34	R:R:F51	R:R:I92	62.0172	5.02	No	Yes	5	6	7
35	R:R:F51	R:R:L55	60.4561	7.31	No	Yes	0	6	5
36	R:R:L55	R:R:L86	53.5892	2.77	Yes	No	0	5	7
37	R:R:L86	R:R:N58	51.8514	6.87	No	Yes	0	7	9
38	R:R:D85	R:R:N58	13.6035	12.12	No	Yes	4	9	9
39	R:R:D85	R:R:S314	12.1897	10.31	No	No	0	9	9
40	R:R:S314	R:R:S54	10.1784	4.89	No	No	0	9	8
41	R:R:F82	R:R:N58	35.7528	3.62	Yes	Yes	4	9	9
42	R:R:F82	R:R:V78	19.5321	3.93	Yes	No	0	9	8
43	R:R:C76	R:R:V78	17.605	3.42	No	No	0	5	8
44	R:R:C76	R:R:L79	11.7731	1.59	No	No	0	5	5
45	R:R:F82	R:R:N322	13.7255	4.83	Yes	No	0	9	7
46	R:R:L325	R:R:N322	11.7731	1.37	No	No	0	8	7
47	L:L:?1	R:R:F211	28.7427	3.7	Yes	Yes	1	0	5
48	R:R:F211	R:R:N215	18.9935	13.29	Yes	Yes	1	5	6
49	R:R:L127	R:R:N215	14.7269	4.12	No	Yes	0	6	6
50	R:R:I162	R:R:L127	16.6793	2.85	Yes	No	0	7	6
51	R:R:A131	R:R:I162	12.602	1.62	No	Yes	0	7	7
52	R:R:A131	R:R:L77	11.2261	1.58	No	No	0	7	7
53	R:R:T125	R:R:W277	12.4674	6.06	No	Yes	0	9	9
54	R:R:L81	R:R:T125	11.1209	4.42	Yes	No	0	9	9
55	R:R:F311	R:R:F88	30.43	6.43	Yes	No	0	7	7
56	R:R:T310	R:R:W277	28.6123	3.64	No	Yes	0	8	9
57	R:R:F88	R:R:T310	28.5113	3.89	No	No	0	7	8
58	L:L:?1	R:R:I280	10.8348	8.67	Yes	Yes	1	0	6
59	R:R:F115	R:R:W104	14.6217	7.02	Yes	Yes	2	5	9
60	R:R:C194	R:R:F177	10.6581	6.98	Yes	Yes	2	9	5
61	R:R:L106	R:R:W104	10.8348	9.11	No	Yes	0	6	9
62	L:L:?1	R:R:L173	13.6077	6.31	Yes	Yes	1	0	5
63	R:R:P172	R:R:W198	12.1644	4.05	No	Yes	1	8	7
64	R:R:L171	R:R:P172	17.8743	4.93	No	No	0	5	8
65	R:R:C174	R:R:L171	13.1406	4.76	No	No	0	4	5
66	R:R:L196	R:R:W198	15.6779	5.69	Yes	Yes	0	5	7
67	L:L:?1	R:R:E204	13.0354	8.05	Yes	Yes	1	0	5
68	R:R:P172	R:R:W207	10.5192	20.27	No	Yes	1	8	6
69	L:L:?1	R:R:D208	10.0017	7.21	Yes	Yes	1	0	5
70	R:R:F176	R:R:W198	15.619	27.06	No	Yes	0	5	7
71	R:R:C174	R:R:Y116	13.5277	8.06	No	No	0	4	5
72	R:R:F273	R:R:W277	90.154	6.01	Yes	Yes	1	9	9
73	R:R:F273	R:R:I223	91.0208	7.54	Yes	No	0	9	8
74	R:R:I223	R:R:S133	86.6027	4.64	No	No	0	8	8
75	R:R:S133	R:R:Y227	85.2268	11.45	No	Yes	0	8	9
76	R:R:S226	R:R:Y227	17.5377	6.36	No	Yes	0	5	9
77	R:R:M137	R:R:S226	15.5979	6.13	Yes	No	0	8	5
78	R:R:L269	R:R:Y227	23.5084	7.03	No	Yes	0	8	9
79	R:R:L266	R:R:Y227	50.9551	2.34	No	Yes	0	8	9
80	R:R:L231	R:R:L266	43.9788	12.46	No	No	0	6	8
81	R:R:K235	R:R:L231	36.5985	2.82	No	No	0	5	6
82	R:R:D259	R:R:K235	34.8481	4.15	No	No	0	7	5
83	R:R:D259	R:R:R238	31.1453	15.48	No	Yes	6	7	4
84	R:R:Q252	R:R:R238	27.4215	5.84	Yes	Yes	0	2	4
85	R:R:L269	R:R:L320	21.5855	5.54	No	No	0	8	8
86	R:R:L268	R:R:L320	17.7144	2.77	No	No	0	6	8
87	R:R:L268	R:R:M323	15.7662	2.83	No	No	0	6	5
88	R:R:M323	R:R:R327	13.8096	4.96	No	No	0	5	8
89	R:R:I280	R:R:T283	11.2303	4.56	Yes	No	0	6	5
90	R:R:I298	R:R:Q290	16.8434	9.61	No	No	0	3	4
91	R:R:L296	R:R:Q290	14.4618	5.32	No	No	0	5	4
92	R:R:K293	R:R:L296	12.0719	14.1	No	No	0	1	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R22	3.69	1	Yes	No	0	5	0	1
L:L:?1	R:R:M118	7.52	1	Yes	No	0	7	0	1
L:L:?1	R:R:T119	10.07	1	Yes	No	0	5	0	1
L:L:?1	R:R:G122	5.2	1	Yes	No	0	7	0	1
L:L:?1	R:R:L173	6.31	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L196	5.26	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:E204	8.05	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:D208	7.21	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F211	3.7	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W277	5.19	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:I280	8.67	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:I284	10.84	1	Yes	No	0	5	0	1
L:L:?1	R:R:I287	15.18	1	Yes	No	0	5	0	1
L:L:?1	R:R:N291	13.56	1	Yes	No	0	2	0	1
R:R:R22	R:R:R24	15.99	0	No	No	5	5	1	2
R:R:F27	R:R:L196	4.87	2	Yes	Yes	5	5	2	1
R:R:F27	R:R:F303	5.36	2	Yes	No	5	4	2	2
R:R:F311	R:R:M118	6.22	0	Yes	No	7	7	2	1
R:R:A170	R:R:T119	3.36	0	No	No	7	5	2	1
R:R:L173	R:R:T119	4.42	1	Yes	No	5	5	1	1
R:R:F211	R:R:S123	3.96	1	Yes	No	5	6	1	2
R:R:N215	R:R:S123	8.94	1	Yes	No	6	6	2	2
R:R:T125	R:R:W277	6.06	0	No	Yes	9	9	2	1
R:R:F273	R:R:I126	5.02	1	Yes	No	9	8	2	2
R:R:I126	R:R:W277	19.97	1	No	Yes	8	9	2	1
R:R:L173	R:R:W198	3.42	1	Yes	Yes	5	7	1	2
R:R:L173	R:R:W207	7.97	1	Yes	Yes	5	6	1	2
R:R:F177	R:R:L196	3.65	2	Yes	Yes	5	5	2	1
R:R:L196	R:R:W198	5.69	0	Yes	Yes	5	7	1	2
R:R:E204	R:R:W198	15.27	1	Yes	Yes	5	7	1	2
R:R:W198	R:R:W207	8.43	1	Yes	Yes	7	6	2	2
R:R:I201	R:R:N291	8.5	0	No	No	4	2	2	1
R:R:D208	R:R:E204	6.5	1	Yes	Yes	5	5	1	1
R:R:E204	R:R:L288	3.98	1	Yes	No	5	4	1	2
R:R:E204	R:R:N291	3.94	1	Yes	No	5	2	1	1
R:R:D208	R:R:W207	7.82	1	Yes	Yes	5	6	1	2
R:R:F211	R:R:W207	8.02	1	Yes	Yes	5	6	1	2
R:R:D208	R:R:L288	9.5	1	Yes	No	5	4	1	2
R:R:F211	R:R:N215	13.29	1	Yes	Yes	5	6	1	2
R:R:F273	R:R:W277	6.01	1	Yes	Yes	9	9	2	1
R:R:T310	R:R:W277	3.64	0	No	Yes	8	9	2	1
R:R:N313	R:R:W277	13.56	0	No	Yes	9	9	2	1
R:R:I280	R:R:T283	4.56	1	Yes	No	6	5	1	2
R:R:I280	R:R:I284	4.42	1	Yes	No	6	5	1	1
R:R:I280	R:R:T310	4.56	1	Yes	No	6	8	1	2
R:R:F303	R:R:I287	3.77	2	No	No	4	5	2	1
R:R:F216	R:R:W277	3.01	0	No	Yes	8	9	2	1
R:R:A169	R:R:F211	2.77	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8T3Q_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	274
Number of Links	312
Number of Hubs	39
Number of Links mediated by Hubs	152
Number of Communities	7
Number of Nodes involved in Communities	50
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	66297
Length Of Smallest Path	3
Average Path Length	12.5817
Length of Longest Path	32
Minimum Path Strength	1.23
Average Path Strength	6.57798
Maximum Path Strength	22.055
Minimum Path Correlation	0.7
Average Path Correlation	0.93983
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	57.5422
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.0657
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein binding • binding • arrestin family protein binding • fatty acid binding • organic acid binding • ion binding • anion binding • lipid binding • carboxylic acid binding • monocarboxylic acid binding • small molecule binding • taste receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion • somatostatin secretion • negative regulation of cell communication • cell communication • negative regulation of peptide secretion • negative regulation of somatostatin secretion • localization • peptide secretion • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of peptide hormone secretion • regulation of biological process • regulation of signaling • negative regulation of peptide hormone secretion • secretion • regulation of transport • regulation of hormone levels • regulation of peptide transport • cell-cell signaling • export from cell • establishment of localization • regulation of secretion • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • hexose transmembrane transport • carbohydrate transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • multicellular organismal process • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • ghrelin secretion • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • developmental process • regulation of osteoblast differentiation • cellular developmental process • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • cell differentiation • phospholipase C-activating G protein-coupled receptor signaling pathway • fat cell differentiation • positive regulation of brown fat cell differentiation • positive regulation of fat cell differentiation • regulation of brown fat cell differentiation • brown fat cell differentiation • regulation of fat cell differentiation • glucagon secretion • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • regulation of glucagon secretion • positive regulation of peptide secretion • positive regulation of glucagon secretion • positive regulation of peptide hormone secretion • positive regulation of transport • white fat cell differentiation • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle • cytoplasm • vesicle • endocytic vesicle • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • endosome membrane • endosome • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • intracellular membraneless organelle • ciliary basal body • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HXA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HXA
Name	Doconexent
Synonyms	(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid
Identifier
Formula	C22 H32 O2
Molecular Weight	328.488
SMILES
PubChem	445580
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5NUL3
Sequence	>8T3Q_nogp_Chain_R R T R F P F F S D V K G D H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R R R R G A T A C L V L N L F C A D L L F I S A I P L V L A V R W T E A W L L G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H L Q R G P G R R A R A V L L A L I W G Y S A V A A L P L C V F F R V V P Q R I S I C T L I W P T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L A Y S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q D L V I W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R N E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G59	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(Gi1-CtGq)/β1/γ2	2.64	2023-03-08	doi.org/10.1126/science.add6220
	8G59 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		2.64	2023-03-08	doi.org/10.1126/science.add6220
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID6	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-	Gi1/β1/γ2	2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID6 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-		2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID8	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID8 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Icosapent	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Icosapent	-		3	2023-03-15	doi.org/10.1126/science.add6220
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8IYS	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP	chim(NtGi1L-Gq)/β1/γ2	2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8IYS (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP		2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8T3O	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3O (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3Q	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3Q (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384

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