psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F115	14.74	Yes	Yes	1	0	5
2	L:L:?1	R:R:M118	6.65	Yes	Yes	0	0	7
3	L:L:?1	R:R:T119	4.96	Yes	Yes	1	0	5
4	L:L:?1	R:R:I126	3.84	Yes	Yes	0	0	8
5	L:L:?1	R:R:L173	3.72	Yes	Yes	1	0	5
6	L:L:?1	R:R:L196	3.72	Yes	No	1	0	5
7	L:L:?1	R:R:W198	3.83	Yes	Yes	1	0	7
8	L:L:?1	R:R:E204	8.91	Yes	Yes	1	0	5
9	L:L:?1	R:R:D208	12.78	Yes	No	1	0	5
10	L:L:?1	R:R:F211	8.19	Yes	Yes	1	0	5
11	L:L:?1	R:R:I280	13.44	Yes	No	0	0	6
12	L:L:?1	R:R:I281	3.84	Yes	No	0	0	7
13	L:L:?1	R:R:I284	15.36	Yes	No	0	0	5
14	L:L:?1	R:R:I287	11.52	Yes	No	0	0	5
15	L:L:?1	R:R:L288	3.72	Yes	No	1	0	4
16	L:L:?1	R:R:V307	4.01	Yes	Yes	1	0	5
17	R:R:R24	R:R:V180	3.92	Yes	No	0	5	4
18	R:R:R24	R:R:T195	10.35	Yes	No	0	5	4
19	R:R:I197	R:R:R24	10.02	No	Yes	0	4	5
20	R:R:F25	R:R:P26	4.33	Yes	No	0	5	5
21	R:R:F25	R:R:F27	10.72	Yes	No	1	5	5
22	R:R:F25	R:R:I298	6.28	Yes	No	0	5	3
23	R:R:F25	R:R:F303	6.43	Yes	Yes	1	5	4
24	R:R:I193	R:R:P26	6.77	Yes	No	0	4	5
25	R:R:P26	R:R:P300	7.79	No	No	0	5	4
26	R:R:F115	R:R:F27	5.36	Yes	No	1	5	5
27	R:R:F27	R:R:F303	10.72	No	Yes	1	5	4
28	R:R:F28	R:R:V95	7.87	No	No	0	8	6
29	R:R:F28	R:R:F303	6.43	No	Yes	1	8	4
30	R:R:F28	R:R:V307	7.87	No	Yes	1	8	5
31	R:R:D30	R:R:P300	8.05	No	No	0	6	4
32	R:R:E43	R:R:K32	5.4	No	Yes	0	5	3
33	R:R:E102	R:R:K32	8.1	No	Yes	0	4	3
34	R:R:E43	R:R:V42	4.28	No	No	0	5	5
35	R:R:E43	R:R:F304	5.83	No	Yes	0	5	4
36	R:R:L96	R:R:T44	8.84	No	Yes	2	6	6
37	R:R:T44	R:R:W100	4.85	Yes	No	2	6	5
38	R:R:V46	R:R:W305	4.9	No	No	0	6	4
39	R:R:I92	R:R:L47	11.42	Yes	Yes	0	7	6
40	R:R:F304	R:R:L47	4.87	Yes	Yes	0	4	6
41	R:R:F51	R:R:I89	3.77	No	No	0	6	6
42	R:R:F51	R:R:I92	6.28	No	Yes	0	6	7
43	R:R:I89	R:R:S54	7.74	No	No	3	6	8
44	R:R:S314	R:R:S54	6.52	No	No	3	9	8
45	R:R:G57	R:R:P318	4.06	No	No	0	9	9
46	R:R:D85	R:R:N58	10.77	No	No	0	9	9
47	R:R:L86	R:R:N58	8.24	No	No	0	7	9
48	R:R:N58	R:R:P318	6.52	No	No	0	9	9
49	R:R:A61	R:R:F82	8.32	No	Yes	0	8	9
50	R:R:F82	R:R:L62	3.65	Yes	No	0	9	6
51	R:R:L79	R:R:V65	5.96	No	No	0	5	7
52	R:R:R69	R:R:R70	7.46	No	No	0	7	7
53	R:R:E135	R:R:L77	10.6	No	No	0	8	7
54	R:R:L77	R:R:R155	3.64	No	No	0	7	6
55	R:R:F82	R:R:V78	3.93	Yes	No	0	9	8
56	R:R:N80	R:R:T128	13.16	No	No	0	9	8
57	R:R:L159	R:R:N80	6.87	No	No	0	7	9
58	R:R:N80	R:R:W163	11.3	No	No	0	9	9
59	R:R:L81	R:R:T128	7.37	No	No	0	9	8
60	R:R:L129	R:R:L81	5.54	No	No	0	8	9
61	R:R:F82	R:R:N322	4.83	Yes	No	0	9	7
62	R:R:D85	R:R:T125	4.34	No	No	0	9	9
63	R:R:D85	R:R:N317	12.12	No	No	0	9	9
64	R:R:F88	R:R:S121	7.93	No	No	0	7	8
65	R:R:F311	R:R:F88	7.5	Yes	No	0	7	7
66	R:R:I89	R:R:S314	6.19	No	No	3	6	9
67	R:R:I92	R:R:P93	6.77	Yes	No	0	7	9
68	R:R:F311	R:R:I92	3.77	Yes	Yes	0	7	7
69	R:R:L94	R:R:P93	4.93	No	No	0	5	9
70	R:R:L114	R:R:L94	8.3	No	No	0	6	5
71	R:R:L96	R:R:W100	4.56	No	No	2	6	5
72	R:R:V98	R:R:W104	6.13	No	Yes	0	5	9
73	R:R:F304	R:R:R99	19.24	Yes	No	0	4	4
74	R:R:L106	R:R:W104	4.56	No	Yes	0	6	9
75	R:R:A110	R:R:W104	3.89	No	Yes	0	5	9
76	R:R:C111	R:R:W104	11.75	No	Yes	4	9	9
77	R:R:L114	R:R:W104	6.83	No	Yes	0	6	9
78	R:R:C194	R:R:W104	15.67	No	Yes	4	9	9
79	R:R:G107	R:R:P108	4.06	No	No	0	8	3
80	R:R:C111	R:R:C194	7.28	No	No	4	9	9
81	R:R:L114	R:R:M118	4.24	No	Yes	0	6	7
82	R:R:F115	R:R:T119	6.49	Yes	Yes	1	5	5
83	R:R:F115	R:R:L173	4.87	Yes	Yes	1	5	5
84	R:R:F115	R:R:F177	18.22	Yes	No	1	5	5
85	R:R:A170	R:R:Y116	4	No	Yes	0	7	5
86	R:R:C174	R:R:Y116	8.06	No	Yes	0	4	5
87	R:R:F311	R:R:M118	3.73	Yes	Yes	0	7	7
88	R:R:L173	R:R:T119	4.42	Yes	Yes	1	5	5
89	R:R:F211	R:R:T119	3.89	Yes	Yes	1	5	5
90	R:R:G122	R:R:T125	3.64	No	No	0	7	9
91	R:R:S123	R:R:S166	6.52	No	No	0	6	8
92	R:R:F211	R:R:S123	3.96	Yes	No	1	5	6
93	R:R:N215	R:R:S123	8.94	Yes	No	1	6	6
94	R:R:V124	R:R:W163	17.16	No	No	0	7	9
95	R:R:S166	R:R:V124	4.85	No	No	0	8	7
96	R:R:T125	R:R:W277	4.85	No	Yes	0	9	9
97	R:R:F273	R:R:I126	5.02	Yes	Yes	0	9	8
98	R:R:I126	R:R:W277	11.74	Yes	Yes	0	8	9
99	R:R:I162	R:R:L127	5.71	No	No	0	7	6
100	R:R:L127	R:R:N215	4.12	No	Yes	0	6	6
101	R:R:L129	R:R:Y321	7.03	No	No	0	8	9
102	R:R:R136	R:R:V132	5.23	No	No	0	9	8
103	R:R:I223	R:R:S133	9.29	No	No	0	8	8
104	R:R:S133	R:R:Y227	10.17	No	Yes	0	8	9
105	R:R:C139	R:R:E135	4.56	No	No	0	8	8
106	R:R:R136	R:R:Y227	7.2	No	Yes	0	9	9
107	R:R:R136	R:R:Y321	6.17	No	No	0	9	9
108	R:R:M137	R:R:S226	7.67	No	No	0	8	5
109	R:R:K229	R:R:M137	5.76	No	No	0	5	8
110	R:R:H142	R:R:V138	4.15	No	No	0	5	4
111	R:R:H142	R:R:Q144	6.18	No	No	0	5	6
112	R:R:R152	R:R:R153	5.33	No	No	0	3	5
113	R:R:A156	R:R:R152	6.91	No	No	0	3	3
114	R:R:L159	R:R:R155	3.64	No	No	0	7	6
115	R:R:L214	R:R:Y165	4.69	No	No	0	4	4
116	R:R:N215	R:R:Y165	5.81	Yes	No	0	6	4
117	R:R:P172	R:R:W198	5.4	No	Yes	1	8	7
118	R:R:P172	R:R:W207	12.16	No	Yes	1	8	6
119	R:R:F177	R:R:L173	6.09	No	Yes	1	5	5
120	R:R:L173	R:R:W207	6.83	Yes	Yes	1	5	6
121	R:R:F176	R:R:V175	9.18	No	No	0	5	4
122	R:R:F176	R:R:W198	6.01	No	Yes	1	5	7
123	R:R:F176	R:R:P199	11.56	No	No	1	5	6
124	R:R:F177	R:R:L196	23.14	No	No	1	5	5
125	R:R:I193	R:R:Q182	4.12	Yes	No	0	4	2
126	R:R:E190	R:R:Q189	5.1	No	No	0	3	1
127	R:R:L196	R:R:W198	10.25	No	Yes	1	5	7
128	R:R:P199	R:R:W198	5.4	No	Yes	1	6	7
129	R:R:E204	R:R:W198	16.36	Yes	Yes	1	5	7
130	R:R:W198	R:R:W207	5.62	Yes	Yes	1	7	6
131	R:R:D208	R:R:E204	5.2	No	Yes	1	5	5
132	R:R:E204	R:R:N291	11.83	Yes	No	0	5	2
133	R:R:F211	R:R:W207	18.04	Yes	Yes	1	5	6
134	R:R:D208	R:R:L288	10.86	No	No	1	5	4
135	R:R:F211	R:R:N215	9.67	Yes	Yes	1	5	6
136	R:R:I281	R:R:V212	4.61	No	No	0	7	6
137	R:R:F216	R:R:L217	4.87	Yes	No	0	8	4
138	R:R:F216	R:R:F273	4.29	Yes	Yes	0	8	9
139	R:R:F216	R:R:S278	3.96	Yes	No	0	8	7
140	R:R:F216	R:R:I281	13.82	Yes	No	0	8	7
141	R:R:F273	R:R:G220	4.52	Yes	No	5	9	6
142	R:R:F274	R:R:G220	4.52	No	No	5	6	6
143	R:R:I225	R:R:L221	5.71	No	No	0	4	2
144	R:R:F273	R:R:I223	6.28	Yes	No	0	9	8
145	R:R:M270	R:R:V224	4.56	No	No	0	8	5
146	R:R:L266	R:R:Y227	10.55	Yes	Yes	0	8	9
147	R:R:L269	R:R:Y227	4.69	No	Yes	0	8	9
148	R:R:K229	R:R:Q232	5.42	No	No	0	5	4
149	R:R:I230	R:R:L266	7.14	No	Yes	0	8	8
150	R:R:L231	R:R:L266	4.15	No	Yes	0	6	8
151	R:R:L262	R:R:T234	4.42	No	Yes	0	8	8
152	R:R:K239	R:R:R238	3.71	No	No	0	5	4
153	R:R:R238	R:R:T242	6.47	No	No	6	4	4
154	R:R:R238	R:R:Y247	5.14	No	Yes	6	4	4
155	R:R:L241	R:R:R240	3.64	Yes	No	0	5	3
156	R:R:A246	R:R:L241	4.73	No	Yes	0	4	5
157	R:R:T242	R:R:Y247	6.24	No	Yes	6	4	4
158	R:R:H251	R:R:Y247	11.98	No	Yes	0	2	4
159	R:R:V255	R:R:Y247	6.31	No	Yes	0	5	4
160	R:R:E249	R:R:S248	5.75	No	No	0	4	6
161	R:R:Q252	R:R:V255	8.6	No	No	0	2	5
162	R:R:Q252	R:R:S256	4.33	No	No	0	2	4
163	R:R:D259	R:R:L262	4.07	No	No	0	7	8
164	R:R:F260	R:R:R264	7.48	No	No	0	6	7
165	R:R:F267	R:R:V271	7.87	No	No	0	5	5
166	R:R:L268	R:R:L320	4.15	No	No	0	6	8
167	R:R:I275	R:R:V271	4.61	No	No	0	5	5
168	R:R:L320	R:R:S272	4.5	No	No	0	8	6
169	R:R:F273	R:R:F274	11.79	Yes	No	5	9	6
170	R:R:F309	R:R:M276	6.22	No	No	0	7	8
171	R:R:M276	R:R:N313	15.43	No	No	0	8	9
172	R:R:T310	R:R:W277	3.64	No	Yes	0	8	9
173	R:R:N313	R:R:W277	27.12	No	Yes	0	9	9
174	R:R:F309	R:R:P279	8.67	No	No	0	7	9
175	R:R:I280	R:R:T310	4.56	No	No	0	6	8
176	R:R:T283	R:R:V306	6.35	No	No	0	5	6
177	R:R:I289	R:R:L285	7.14	No	No	0	4	6
178	R:R:N291	R:R:Q290	6.6	No	No	0	2	4
179	R:R:I298	R:R:L302	5.71	No	No	0	3	5
180	R:R:L302	R:R:W299	11.39	No	No	0	5	4
181	R:R:F303	R:R:V307	5.24	Yes	Yes	1	4	5
182	R:R:F304	R:R:W305	11.02	Yes	No	0	4	4
183	R:R:F311	R:R:V307	3.93	Yes	Yes	0	7	5
184	R:R:L316	R:R:L320	5.54	No	No	0	6	8
185	R:R:M270	R:R:Y227	3.59	No	Yes	0	8	9
186	R:R:P181	R:R:V180	3.53	No	No	0	2	4
187	R:R:P219	R:R:V218	3.53	No	No	0	9	5
188	R:R:L171	R:R:Y116	3.52	No	Yes	0	5	5
189	R:R:L241	R:R:Y247	3.52	Yes	Yes	0	5	4
190	R:R:P202	R:R:T200	3.5	No	No	0	3	3
191	R:R:A315	R:R:S54	3.42	No	No	0	6	8
192	R:R:C174	R:R:V175	3.42	No	No	0	4	4
193	R:R:C194	R:R:V179	3.42	No	No	0	9	5
194	R:R:A315	R:R:V53	3.39	No	No	0	6	5
195	R:R:A84	R:R:V124	3.39	No	No	0	8	7
196	R:R:H112	R:R:R178	3.39	No	No	0	7	4
197	R:R:I126	R:R:P219	3.39	Yes	No	0	8	9
198	R:R:A130	R:R:V222	3.39	No	No	0	7	6
199	R:R:I201	R:R:P202	3.39	No	No	0	4	3
200	R:R:S133	R:R:S226	3.26	No	No	0	8	5
201	R:R:A91	R:R:M118	3.22	No	Yes	0	6	7
202	R:R:A40	R:R:K32	3.21	No	Yes	0	5	3
203	R:R:V65	R:R:V78	3.21	No	No	0	7	8
204	R:R:V132	R:R:V78	3.21	No	No	0	8	8
205	R:R:R152	R:R:R155	3.2	No	No	0	3	6
206	R:R:I193	R:R:S29	3.1	Yes	No	0	4	9
207	R:R:I282	R:R:S278	3.1	No	No	0	5	7
208	R:R:I280	R:R:V306	3.07	No	No	0	6	6
209	R:R:M137	R:R:V141	3.04	No	No	0	8	6
210	R:R:I193	R:R:T195	3.04	Yes	No	0	4	4
211	R:R:L134	R:R:S226	3	No	No	0	5	5
212	R:R:L37	R:R:V38	2.98	No	No	0	3	3
213	R:R:L113	R:R:V109	2.98	No	No	0	5	2
214	R:R:L134	R:R:V138	2.98	No	No	0	5	4
215	R:R:L49	R:R:T45	2.95	No	No	0	4	4
216	R:R:L105	R:R:T101	2.95	No	No	0	4	4
217	R:R:D30	R:R:S301	2.94	No	No	0	6	2
218	R:R:I140	R:R:I230	2.94	No	No	0	8	8
219	R:R:I140	R:R:I233	2.94	No	No	0	8	5
220	R:R:I201	R:R:I205	2.94	No	Yes	0	4	4
221	R:R:I50	R:R:L47	2.85	No	Yes	0	7	6
222	R:R:I282	R:R:L286	2.85	No	No	0	5	5
223	R:R:I298	R:R:L286	2.85	No	No	0	3	5
224	R:R:L316	R:R:M276	2.83	No	No	0	6	8
225	R:R:K32	R:R:L39	2.82	Yes	No	0	3	4
226	R:R:A66	R:R:R67	2.77	No	No	0	1	6
227	R:R:I253	R:R:Q257	2.74	No	No	0	3	5
228	R:R:A167	R:R:Y116	2.67	No	Yes	0	3	5
229	R:R:R67	R:R:V63	2.62	No	No	0	6	4
230	R:R:R68	R:R:V65	2.62	No	No	0	6	7
231	R:R:R24	R:R:T23	2.59	Yes	No	0	5	8
232	R:R:I197	R:R:R178	2.51	No	No	0	4	4
233	R:R:F292	R:R:I205	2.51	No	Yes	0	1	4
234	R:R:V297	R:R:W299	2.45	No	No	0	4	4
235	R:R:F263	R:R:L231	2.44	No	No	0	7	6
236	R:R:L120	R:R:Y116	2.34	No	Yes	0	5	5
237	R:R:Q257	R:R:R254	2.34	No	No	0	5	4
238	R:R:A130	R:R:P219	1.87	No	No	0	7	9
239	R:R:P108	R:R:V179	1.77	No	No	0	3	5
240	R:R:G57	R:R:L56	1.71	No	No	0	9	4
241	R:R:A103	R:R:S192	1.71	No	No	0	5	3
242	R:R:A41	R:R:T44	1.68	No	Yes	0	3	6
243	R:R:A312	R:R:I50	1.62	No	No	0	5	7
244	R:R:A103	R:R:I191	1.62	No	No	0	5	4
245	R:R:A131	R:R:I162	1.62	No	No	0	7	7
246	R:R:S192	R:R:V179	1.62	No	No	0	3	5
247	R:R:T44	R:R:V48	1.59	Yes	No	0	6	4
248	R:R:C60	R:R:L64	1.59	No	No	0	6	7
249	R:R:C83	R:R:L62	1.59	No	No	0	5	6
250	R:R:T213	R:R:V218	1.59	No	No	0	5	5
251	R:R:A308	R:R:L47	1.58	No	Yes	0	4	6
252	R:R:A103	R:R:L105	1.58	No	No	0	5	4
253	R:R:A131	R:R:L158	1.58	No	No	0	7	5
254	R:R:T44	R:R:T45	1.57	Yes	No	0	6	4
255	R:R:I205	R:R:S206	1.55	Yes	No	0	4	4
256	R:R:I230	R:R:T234	1.52	No	Yes	0	8	8
257	R:R:I233	R:R:T234	1.52	No	Yes	0	5	8
258	R:R:K239	R:R:V243	1.52	No	No	0	5	2
259	R:R:L87	R:R:S90	1.5	No	No	0	6	4
260	R:R:L87	R:R:S121	1.5	No	No	0	6	8
261	R:R:K235	R:R:T234	1.5	No	Yes	0	5	8
262	R:R:L241	R:R:S237	1.5	Yes	No	0	5	6
263	R:R:L64	R:R:V63	1.49	No	No	0	7	4
264	R:R:L296	R:R:V297	1.49	No	No	0	5	4
265	R:R:L266	R:R:T265	1.47	Yes	No	0	8	8
266	R:R:D30	R:R:V31	1.46	No	No	0	6	6
267	R:R:I319	R:R:M323	1.46	No	No	0	7	5
268	R:R:Q232	R:R:S228	1.44	No	No	0	4	3
269	R:R:I205	R:R:L288	1.43	Yes	No	0	4	4
270	R:R:G164	R:R:W163	1.41	No	No	0	4	9
271	R:R:A169	R:R:F211	1.39	No	Yes	0	5	5
272	R:R:H251	R:R:S248	1.39	No	No	0	2	6
273	R:R:L55	R:R:L86	1.38	No	No	0	5	7
274	R:R:A40	R:R:W100	1.3	No	No	0	5	5
275	R:R:R264	R:R:T265	1.29	No	No	0	7	8
276	R:R:D34	R:R:H35	1.26	No	No	0	3	3
277	R:R:K32	R:R:R36	1.24	Yes	No	0	3	4
278	R:R:R261	R:R:R264	1.07	No	No	0	8	7
279	R:R:F263	R:R:F267	1.07	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.70188	16	1	0
2	R:R:R24	6.72	4	0	5
3	R:R:F25	6.94	4	1	5
4	R:R:K32	4.154	5	0	3
5	R:R:T44	3.706	5	2	6
6	R:R:L47	5.18	4	0	6
7	R:R:F82	5.1825	4	0	9
8	R:R:I92	7.06	4	0	7
9	R:R:W104	8.13833	6	4	9
10	R:R:F115	9.936	5	1	5
11	R:R:Y116	4.118	5	0	5
12	R:R:M118	4.46	4	0	7
13	R:R:T119	4.94	4	1	5
14	R:R:I126	5.9975	4	0	8
15	R:R:L173	5.186	5	1	5
16	R:R:I193	4.2575	4	0	4
17	R:R:W198	7.55286	7	1	7
18	R:R:E204	10.575	4	1	5
19	R:R:I205	2.1075	4	0	4
20	R:R:W207	10.6625	4	1	6
21	R:R:F211	7.52333	6	1	5
22	R:R:N215	7.135	4	1	6
23	R:R:F216	6.735	4	0	8
24	R:R:Y227	7.24	5	0	9
25	R:R:T234	2.24	4	0	8
26	R:R:L241	3.3475	4	0	5
27	R:R:Y247	6.638	5	6	4
28	R:R:L266	5.8275	4	0	8
29	R:R:F273	6.38	5	5	9
30	R:R:W277	11.8375	4	0	9
31	R:R:F303	7.205	4	1	4
32	R:R:F304	10.24	4	0	4
33	R:R:V307	5.2625	4	1	5
34	R:R:F311	4.7325	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F115	26.9423	14.74	Yes	Yes	1	0	5
2	R:R:F115	R:R:F27	29.7536	5.36	Yes	No	1	5	5
3	R:R:F25	R:R:F27	28.6406	10.72	Yes	No	1	5	5
4	R:R:F25	R:R:P26	47.2863	4.33	Yes	No	0	5	5
5	R:R:I193	R:R:P26	32.9045	6.77	Yes	No	0	4	5
6	R:R:I193	R:R:T195	24.102	3.04	Yes	No	0	4	4
7	R:R:R24	R:R:T195	21.139	10.35	Yes	No	0	5	4
8	L:L:?1	R:R:V307	63.6482	4.01	Yes	Yes	1	0	5
9	R:R:F303	R:R:V307	33.8802	5.24	Yes	Yes	1	4	5
10	R:R:F25	R:R:F303	32.7528	6.43	Yes	Yes	1	5	4
11	R:R:F25	R:R:I298	13.8758	6.28	Yes	No	0	5	3
12	R:R:P26	R:R:P300	12.163	7.79	No	No	0	5	4
13	L:L:?1	R:R:M118	62.9544	6.65	Yes	Yes	0	0	7
14	R:R:F311	R:R:M118	44.0413	3.73	Yes	Yes	0	7	7
15	R:R:F311	R:R:I92	73.4191	3.77	Yes	Yes	0	7	7
16	R:R:I92	R:R:L47	57.5341	11.42	Yes	Yes	0	7	6
17	R:R:F304	R:R:L47	47.438	4.87	Yes	Yes	0	4	6
18	R:R:E43	R:R:F304	37.4575	5.83	No	Yes	0	5	4
19	R:R:F311	R:R:V307	47.4236	3.93	Yes	Yes	0	7	5
20	R:R:E43	R:R:K32	32.1963	5.4	No	Yes	0	5	3
21	R:R:A40	R:R:K32	22.0207	3.21	No	Yes	0	5	3
22	R:R:A40	R:R:W100	19.3178	1.3	No	No	0	5	5
23	R:R:T44	R:R:W100	13.8325	4.85	Yes	No	2	6	5
24	R:R:F51	R:R:I92	16.6004	6.28	No	Yes	0	6	7
25	R:R:F51	R:R:I89	13.8686	3.77	No	No	0	6	6
26	L:L:?1	R:R:I126	100	3.84	Yes	Yes	0	0	8
27	R:R:I126	R:R:W277	36.4169	11.74	Yes	Yes	0	8	9
28	R:R:T125	R:R:W277	19.867	4.85	No	Yes	0	9	9
29	R:R:D85	R:R:T125	16.0078	4.34	No	No	0	9	9
30	R:R:D85	R:R:N58	12.0908	10.77	No	No	0	9	9
31	R:R:F273	R:R:I126	74.3875	5.02	Yes	Yes	0	9	8
32	R:R:F273	R:R:I223	74.0262	6.28	Yes	No	0	9	8
33	R:R:I223	R:R:S133	72.8337	9.29	No	No	0	8	8
34	R:R:S133	R:R:Y227	59.0807	10.17	No	Yes	0	8	9
35	R:R:R136	R:R:Y227	27.3181	7.2	No	Yes	0	9	9
36	R:R:R136	R:R:V132	19.5057	5.23	No	No	0	9	8
37	R:R:V132	R:R:V78	17.6194	3.21	No	No	0	8	8
38	L:L:?1	R:R:F211	43.9618	8.19	Yes	Yes	1	0	5
39	R:R:F211	R:R:S123	31.5386	3.96	Yes	No	1	5	6
40	R:R:S123	R:R:S166	30.4184	6.52	No	No	0	6	8
41	R:R:S166	R:R:V124	28.4816	4.85	No	No	0	8	7
42	R:R:V124	R:R:W163	25.2005	17.16	No	No	0	7	9
43	R:R:N80	R:R:W163	22.1797	11.3	No	No	0	9	9
44	R:R:L159	R:R:N80	18.1398	6.87	No	No	0	7	9
45	R:R:L159	R:R:R155	15.8994	3.64	No	No	0	7	6
46	R:R:F311	R:R:F88	10.7176	7.5	Yes	No	0	7	7
47	R:R:L114	R:R:M118	30.7581	4.24	No	Yes	0	6	7
48	R:R:L114	R:R:W104	29.5657	6.83	No	Yes	0	6	9
49	R:R:C194	R:R:W104	19.3105	15.67	No	Yes	4	9	9
50	R:R:C194	R:R:V179	17.2798	3.42	No	No	0	9	5
51	L:L:?1	R:R:W198	21.9701	3.83	Yes	Yes	1	0	7
52	R:R:F176	R:R:W198	17.4532	6.01	No	Yes	1	5	7
53	R:R:F176	R:R:V175	15.3718	9.18	No	No	0	5	4
54	R:R:C174	R:R:V175	13.2182	3.42	No	No	0	4	4
55	R:R:C174	R:R:Y116	11.0501	8.06	No	Yes	0	4	5
56	R:R:F211	R:R:N215	15.1695	9.67	Yes	Yes	1	5	6
57	R:R:S133	R:R:S226	19.5057	3.26	No	No	0	8	5
58	R:R:L266	R:R:Y227	33.7067	10.55	Yes	Yes	0	8	9
59	R:R:I230	R:R:L266	15.3285	7.14	No	Yes	0	8	8
60	R:R:N313	R:R:W277	16.0078	27.12	No	Yes	0	9	9
61	R:R:M276	R:R:N313	14.0565	15.43	No	No	0	8	9
62	R:R:I298	R:R:L302	10.6887	5.71	No	No	0	3	5
63	R:R:I126	R:R:P219	10.1106	3.39	Yes	No	0	8	9
64	L:L:?1	R:R:L288	13.8903	3.72	Yes	No	1	0	4
65	R:R:I205	R:R:L288	12.3076	1.43	Yes	No	0	4	4
66	R:R:S192	R:R:V179	10.9055	1.62	No	No	0	3	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F115	14.74	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M118	6.65	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T119	4.96	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I126	3.84	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L173	3.72	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L196	3.72	1	Yes	No	0	5	0	1
L:L:?1	R:R:W198	3.83	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:E204	8.91	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:D208	12.78	1	Yes	No	0	5	0	1
L:L:?1	R:R:F211	8.19	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I280	13.44	1	Yes	No	0	6	0	1
L:L:?1	R:R:I281	3.84	1	Yes	No	0	7	0	1
L:L:?1	R:R:I284	15.36	1	Yes	No	0	5	0	1
L:L:?1	R:R:I287	11.52	1	Yes	No	0	5	0	1
L:L:?1	R:R:L288	3.72	1	Yes	No	0	4	0	1
L:L:?1	R:R:V307	4.01	1	Yes	Yes	0	5	0	1
R:R:F115	R:R:F27	5.36	1	Yes	No	5	5	1	2
R:R:F27	R:R:F303	10.72	1	No	Yes	5	4	2	2
R:R:F28	R:R:F303	6.43	1	No	Yes	8	4	2	2
R:R:F28	R:R:V307	7.87	1	No	Yes	8	5	2	1
R:R:L114	R:R:M118	4.24	0	No	Yes	6	7	2	1
R:R:F115	R:R:T119	6.49	1	Yes	Yes	5	5	1	1
R:R:F115	R:R:L173	4.87	1	Yes	Yes	5	5	1	1
R:R:F115	R:R:F177	18.22	1	Yes	No	5	5	1	2
R:R:F311	R:R:M118	3.73	0	Yes	Yes	7	7	2	1
R:R:L173	R:R:T119	4.42	1	Yes	Yes	5	5	1	1
R:R:F211	R:R:T119	3.89	1	Yes	Yes	5	5	1	1
R:R:F211	R:R:S123	3.96	1	Yes	No	5	6	1	2
R:R:N215	R:R:S123	8.94	1	Yes	No	6	6	2	2
R:R:F273	R:R:I126	5.02	5	Yes	Yes	9	8	2	1
R:R:I126	R:R:W277	11.74	0	Yes	Yes	8	9	1	2
R:R:P172	R:R:W198	5.4	1	No	Yes	8	7	2	1
R:R:P172	R:R:W207	12.16	1	No	Yes	8	6	2	2
R:R:F177	R:R:L173	6.09	1	No	Yes	5	5	2	1
R:R:L173	R:R:W207	6.83	1	Yes	Yes	5	6	1	2
R:R:F176	R:R:W198	6.01	1	No	Yes	5	7	2	1
R:R:F176	R:R:P199	11.56	1	No	No	5	6	2	2
R:R:F177	R:R:L196	23.14	1	No	No	5	5	2	1
R:R:L196	R:R:W198	10.25	1	No	Yes	5	7	1	1
R:R:P199	R:R:W198	5.4	1	No	Yes	6	7	2	1
R:R:E204	R:R:W198	16.36	1	Yes	Yes	5	7	1	1
R:R:W198	R:R:W207	5.62	1	Yes	Yes	7	6	1	2
R:R:D208	R:R:E204	5.2	1	No	Yes	5	5	1	1
R:R:E204	R:R:N291	11.83	1	Yes	No	5	2	1	2
R:R:F211	R:R:W207	18.04	1	Yes	Yes	5	6	1	2
R:R:D208	R:R:L288	10.86	1	No	No	5	4	1	1
R:R:F211	R:R:N215	9.67	1	Yes	Yes	5	6	1	2
R:R:I281	R:R:V212	4.61	0	No	No	7	6	1	2
R:R:F216	R:R:F273	4.29	0	Yes	Yes	8	9	2	2
R:R:F216	R:R:I281	13.82	0	Yes	No	8	7	2	1
R:R:T310	R:R:W277	3.64	0	No	Yes	8	9	2	2
R:R:I280	R:R:T310	4.56	0	No	No	6	8	1	2
R:R:F303	R:R:V307	5.24	1	Yes	Yes	4	5	2	1
R:R:F311	R:R:V307	3.93	0	Yes	Yes	7	5	2	1
R:R:I126	R:R:P219	3.39	0	Yes	No	8	9	1	2
R:R:A91	R:R:M118	3.22	0	No	Yes	6	7	2	1
R:R:I280	R:R:V306	3.07	0	No	No	6	6	1	2
R:R:I205	R:R:L288	1.43	0	Yes	No	4	4	2	1
R:R:A169	R:R:F211	1.39	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8G59_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.64
Number of Linked Nodes	261
Number of Links	279
Number of Hubs	34
Number of Links mediated by Hubs	133
Number of Communities	6
Number of Nodes involved in Communities	37
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	35620
Length Of Smallest Path	3
Average Path Length	11.2388
Length of Longest Path	24
Minimum Path Strength	1.18
Average Path Strength	6.33329
Maximum Path Strength	21.275
Minimum Path Correlation	0.7
Average Path Correlation	0.938903
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	62.842
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.6785
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein binding • binding • arrestin family protein binding • fatty acid binding • organic acid binding • ion binding • anion binding • lipid binding • carboxylic acid binding • monocarboxylic acid binding • small molecule binding • taste receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion • somatostatin secretion • negative regulation of cell communication • cell communication • negative regulation of peptide secretion • negative regulation of somatostatin secretion • localization • peptide secretion • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of peptide hormone secretion • regulation of biological process • regulation of signaling • negative regulation of peptide hormone secretion • secretion • regulation of transport • regulation of hormone levels • regulation of peptide transport • cell-cell signaling • export from cell • establishment of localization • regulation of secretion • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • hexose transmembrane transport • carbohydrate transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • multicellular organismal process • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • ghrelin secretion • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • developmental process • regulation of osteoblast differentiation • cellular developmental process • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • cell differentiation • phospholipase C-activating G protein-coupled receptor signaling pathway • fat cell differentiation • positive regulation of brown fat cell differentiation • positive regulation of fat cell differentiation • regulation of brown fat cell differentiation • brown fat cell differentiation • regulation of fat cell differentiation • glucagon secretion • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • regulation of glucagon secretion • positive regulation of peptide secretion • positive regulation of glucagon secretion • positive regulation of peptide hormone secretion • positive regulation of transport • white fat cell differentiation • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle • cytoplasm • vesicle • endocytic vesicle • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • endosome membrane • endosome • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • intracellular membraneless organelle • ciliary basal body • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D2 dopamine receptor binding • dopamine receptor binding • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • response to endogenous stimulus • hormone-mediated signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • glutamate receptor signaling pathway • system process • sensory perception • nervous system process • sensory perception of itch • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • nuclear membrane • nucleus • organelle envelope • nuclear envelope • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor outer segment • photoreceptor cell cilium • Golgi apparatus • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • midbody • membrane-enclosed lumen • nucleolus • intracellular organelle lumen • organelle lumen • nuclear lumen • cell cortex • centrosome • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • photoreceptor disc membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YN9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YN9
Name	3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid
Synonyms
Identifier
Formula	C23 H21 F O3
Molecular Weight	364.409
SMILES
PubChem	57522038
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	0
Total Bonds	50
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5NUL3
Sequence	>8G59_nogp_Chain_R T R F P F F S D V K G D H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R R R L V L N L F C A D L L F I S A I P L V L A V R W T E A W L L G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H L Q G R R A R A V L L A L I W G Y S A V A A L P L C V F F R V V P Q Q E I S I C T L I W P T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L A Y S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F L V I W P S L F F W V V A F T F A N S A L N P I L Y N M T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G59	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(Gi1-CtGq)/β1/γ2	2.64	2023-03-08	doi.org/10.1126/science.add6220
	8G59 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		2.64	2023-03-08	doi.org/10.1126/science.add6220
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID6	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-	Gi1/β1/γ2	2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID6 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-		2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID8	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID8 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Icosapent	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Icosapent	-		3	2023-03-15	doi.org/10.1126/science.add6220
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8IYS	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP	chim(NtGi1L-Gq)/β1/γ2	2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8IYS (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP		2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8T3O	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3O (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3Q	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3Q (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384

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