psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F88	3.28	Yes	Yes	1	0	7
2	L:L:?1	R:R:M118	5.7	Yes	Yes	1	0	7
3	L:L:?1	R:R:T119	6.94	Yes	No	1	0	5
4	L:L:?1	R:R:L173	4.65	Yes	No	1	0	5
5	L:L:?1	R:R:E204	7.13	Yes	No	0	0	5
6	L:L:?1	R:R:D208	8.21	Yes	No	0	0	5
7	L:L:?1	R:R:F211	9.83	Yes	Yes	0	0	5
8	L:L:?1	R:R:I280	18.24	Yes	No	0	0	6
9	L:L:?1	R:R:I284	8.64	Yes	No	0	0	5
10	L:L:?1	R:R:I287	3.84	Yes	No	1	0	5
11	L:L:?1	R:R:V307	4.01	Yes	Yes	1	0	5
12	R:R:R24	R:R:T195	5.17	No	No	0	5	4
13	R:R:I197	R:R:R24	3.76	No	No	0	4	5
14	R:R:F25	R:R:P26	4.33	Yes	Yes	1	5	5
15	R:R:F25	R:R:F27	5.36	Yes	No	0	5	5
16	R:R:F25	R:R:I287	5.02	Yes	No	1	5	5
17	R:R:F25	R:R:Q290	9.37	Yes	No	1	5	4
18	R:R:F25	R:R:I298	18.84	Yes	Yes	1	5	3
19	R:R:P26	R:R:S29	3.56	Yes	No	1	5	9
20	R:R:P26	R:R:Q182	6.32	Yes	No	1	5	2
21	R:R:I193	R:R:P26	8.47	Yes	Yes	1	4	5
22	R:R:F115	R:R:F27	6.43	Yes	No	0	5	5
23	R:R:F27	R:R:L196	3.65	No	Yes	0	5	5
24	R:R:F28	R:R:V95	13.11	Yes	No	0	8	6
25	R:R:F115	R:R:F28	9.65	Yes	Yes	0	5	8
26	R:R:F28	R:R:F303	5.36	Yes	No	1	8	4
27	R:R:F28	R:R:F304	6.43	Yes	Yes	1	8	4
28	R:R:F28	R:R:V307	5.24	Yes	Yes	1	8	5
29	R:R:I193	R:R:S29	4.64	Yes	No	1	4	9
30	R:R:D30	R:R:R99	7.15	No	No	0	6	4
31	R:R:E102	R:R:K32	4.05	No	No	0	4	3
32	R:R:D34	R:R:H35	10.08	No	No	0	3	3
33	R:R:H35	R:R:R36	3.39	No	No	0	3	4
34	R:R:H35	R:R:V38	4.15	No	No	0	3	3
35	R:R:E43	R:R:T44	9.88	Yes	Yes	0	5	6
36	R:R:E43	R:R:L47	6.63	Yes	No	1	5	6
37	R:R:E43	R:R:L96	3.98	Yes	No	1	5	6
38	R:R:E43	R:R:R99	13.96	Yes	No	1	5	4
39	R:R:E43	R:R:F304	8.16	Yes	Yes	1	5	4
40	R:R:L47	R:R:L96	6.92	No	No	1	6	6
41	R:R:F304	R:R:L47	4.87	Yes	No	1	4	6
42	R:R:F51	R:R:I89	6.28	No	No	0	6	6
43	R:R:F51	R:R:I92	6.28	No	No	0	6	7
44	R:R:I89	R:R:S54	6.19	No	No	0	6	8
45	R:R:A315	R:R:S54	3.42	No	No	0	6	8
46	R:R:G57	R:R:L56	5.13	No	No	0	9	4
47	R:R:F82	R:R:N58	7.25	Yes	No	0	9	9
48	R:R:D85	R:R:N58	5.39	Yes	No	0	9	9
49	R:R:L86	R:R:N58	5.49	No	No	0	7	9
50	R:R:A61	R:R:F82	5.55	No	Yes	0	8	9
51	R:R:L62	R:R:L79	9.69	No	No	0	6	5
52	R:R:L64	R:R:R67	3.64	No	No	0	7	6
53	R:R:L79	R:R:V65	13.41	No	No	0	5	7
54	R:R:A75	R:R:R155	8.3	No	Yes	0	8	6
55	R:R:L159	R:R:L77	4.15	No	No	0	7	7
56	R:R:F82	R:R:V78	5.24	Yes	No	0	9	8
57	R:R:F82	R:R:L79	4.87	Yes	No	0	9	5
58	R:R:N80	R:R:T128	5.85	Yes	No	0	9	8
59	R:R:L159	R:R:N80	10.98	No	Yes	0	7	9
60	R:R:N80	R:R:W163	10.17	Yes	No	0	9	9
61	R:R:L81	R:R:T128	5.9	No	No	0	9	8
62	R:R:L81	R:R:N317	9.61	No	No	0	9	9
63	R:R:D85	R:R:T125	4.34	Yes	No	0	9	9
64	R:R:D85	R:R:S314	8.83	Yes	No	0	9	9
65	R:R:D85	R:R:N317	8.08	Yes	No	0	9	9
66	R:R:L87	R:R:V117	4.47	No	No	0	6	4
67	R:R:L87	R:R:S121	6.01	No	No	0	6	8
68	R:R:F88	R:R:M118	3.73	Yes	Yes	1	7	7
69	R:R:F88	R:R:S121	10.57	Yes	No	0	7	8
70	R:R:F311	R:R:F88	6.43	Yes	Yes	1	7	7
71	R:R:F88	R:R:S314	7.93	Yes	No	0	7	9
72	R:R:I92	R:R:P93	3.39	No	No	0	7	9
73	R:R:F311	R:R:I92	6.28	Yes	No	0	7	7
74	R:R:L114	R:R:L94	5.54	No	No	0	6	5
75	R:R:V98	R:R:W104	11.03	No	Yes	0	5	9
76	R:R:F304	R:R:R99	22.45	Yes	No	1	4	4
77	R:R:L105	R:R:T101	4.42	No	No	0	4	4
78	R:R:L106	R:R:W104	9.11	No	Yes	0	6	9
79	R:R:C111	R:R:W104	9.14	No	Yes	4	9	9
80	R:R:C194	R:R:W104	13.06	No	Yes	4	9	9
81	R:R:G107	R:R:P108	4.06	No	No	0	8	3
82	R:R:P108	R:R:V179	3.53	No	No	0	3	5
83	R:R:C111	R:R:C194	7.28	No	No	4	9	9
84	R:R:F115	R:R:L114	3.65	Yes	No	0	5	6
85	R:R:F115	R:R:M118	3.73	Yes	Yes	0	5	7
86	R:R:F115	R:R:F177	9.65	Yes	No	0	5	5
87	R:R:C174	R:R:Y116	8.06	No	No	0	4	5
88	R:R:F311	R:R:M118	3.73	Yes	Yes	1	7	7
89	R:R:A170	R:R:T119	3.36	No	No	0	7	5
90	R:R:L173	R:R:T119	5.9	No	No	1	5	5
91	R:R:L120	R:R:W163	3.42	No	No	0	5	9
92	R:R:L120	R:R:S166	6.01	No	No	0	5	8
93	R:R:G122	R:R:T125	3.64	No	No	0	7	9
94	R:R:S123	R:R:S166	6.52	No	No	0	6	8
95	R:R:N215	R:R:S123	4.47	Yes	No	0	6	6
96	R:R:V124	R:R:W163	14.71	No	No	0	7	9
97	R:R:I126	R:R:P219	3.39	No	No	0	8	9
98	R:R:F273	R:R:I126	5.02	Yes	No	3	9	8
99	R:R:I126	R:R:W277	14.09	No	Yes	3	8	9
100	R:R:L129	R:R:Y321	7.03	No	No	0	8	9
101	R:R:A130	R:R:V222	3.39	No	No	0	7	6
102	R:R:R136	R:R:V132	5.23	No	No	2	9	8
103	R:R:V132	R:R:Y321	3.79	No	No	2	8	9
104	R:R:I223	R:R:S133	9.29	No	No	2	8	8
105	R:R:S133	R:R:S226	4.89	No	Yes	2	8	5
106	R:R:S133	R:R:Y227	8.9	No	Yes	2	8	9
107	R:R:E135	R:R:R155	6.98	No	Yes	0	8	6
108	R:R:R136	R:R:Y227	4.12	No	Yes	2	9	9
109	R:R:R136	R:R:Y321	6.17	No	No	2	9	9
110	R:R:M137	R:R:V141	4.56	Yes	No	0	8	6
111	R:R:K229	R:R:M137	8.64	No	Yes	0	5	8
112	R:R:I230	R:R:M137	4.37	No	Yes	0	8	8
113	R:R:H142	R:R:V138	9.69	No	No	0	5	4
114	R:R:R153	R:R:V157	6.54	No	No	0	5	4
115	R:R:L214	R:R:Y165	7.03	No	No	0	4	4
116	R:R:N215	R:R:Y165	11.63	Yes	No	0	6	4
117	R:R:L171	R:R:P172	3.28	No	No	0	5	8
118	R:R:P172	R:R:W207	9.46	No	Yes	0	8	6
119	R:R:L173	R:R:L196	4.15	No	Yes	0	5	5
120	R:R:F176	R:R:V175	6.55	No	No	0	5	4
121	R:R:F176	R:R:W198	8.02	No	Yes	0	5	7
122	R:R:F177	R:R:L196	12.18	No	Yes	0	5	5
123	R:R:C194	R:R:V179	5.12	No	No	0	9	5
124	R:R:P181	R:R:V180	3.53	No	No	0	2	4
125	R:R:I193	R:R:Q182	8.23	Yes	No	1	4	2
126	R:R:L196	R:R:W198	7.97	Yes	Yes	0	5	7
127	R:R:P199	R:R:W198	4.05	No	Yes	0	6	7
128	R:R:E204	R:R:W198	14.17	No	Yes	0	5	7
129	R:R:W198	R:R:W207	5.62	Yes	Yes	0	7	6
130	R:R:I201	R:R:P202	11.85	No	No	0	4	3
131	R:R:E204	R:R:N291	9.2	No	No	0	5	2
132	R:R:I205	R:R:L288	5.71	No	No	0	4	4
133	R:R:D208	R:R:W207	7.82	No	Yes	0	5	6
134	R:R:F211	R:R:W207	14.03	Yes	Yes	0	5	6
135	R:R:D208	R:R:L288	6.79	No	No	0	5	4
136	R:R:F211	R:R:N215	10.87	Yes	Yes	0	5	6
137	R:R:I281	R:R:V212	6.14	No	No	0	7	6
138	R:R:F216	R:R:F273	4.29	No	Yes	0	8	9
139	R:R:F216	R:R:I281	16.33	No	No	0	8	7
140	R:R:P219	R:R:V218	3.53	No	No	0	9	5
141	R:R:F274	R:R:G220	4.52	No	No	0	6	6
142	R:R:I223	R:R:Y227	6.04	No	Yes	2	8	9
143	R:R:M270	R:R:V224	4.56	No	No	0	8	5
144	R:R:S226	R:R:Y227	5.09	Yes	Yes	2	5	9
145	R:R:L266	R:R:Y227	5.86	No	Yes	0	8	9
146	R:R:L269	R:R:Y227	8.21	No	Yes	0	8	9
147	R:R:M270	R:R:Y227	4.79	No	Yes	0	8	9
148	R:R:F263	R:R:L231	4.87	No	No	0	7	6
149	R:R:L231	R:R:L266	4.15	No	No	0	6	8
150	R:R:L262	R:R:T234	4.42	No	No	0	8	8
151	R:R:R238	R:R:S237	7.91	No	No	0	4	6
152	R:R:D259	R:R:R238	10.72	No	No	0	7	4
153	R:R:L241	R:R:Y247	7.03	No	Yes	0	5	4
154	R:R:H251	R:R:Y247	7.62	Yes	Yes	0	2	4
155	R:R:Q252	R:R:Y247	5.64	No	Yes	0	2	4
156	R:R:H251	R:R:R254	11.28	Yes	No	0	2	4
157	R:R:F260	R:R:R264	4.28	No	No	0	6	7
158	R:R:L262	R:R:L266	4.15	No	No	0	8	8
159	R:R:L269	R:R:L320	4.15	No	No	0	8	8
160	R:R:F273	R:R:F274	9.65	Yes	No	0	9	6
161	R:R:F273	R:R:W277	4.01	Yes	Yes	3	9	9
162	R:R:F309	R:R:M276	7.46	No	Yes	0	7	8
163	R:R:M276	R:R:N313	11.22	Yes	Yes	3	8	9
164	R:R:L316	R:R:M276	4.24	No	Yes	3	6	8
165	R:R:T310	R:R:W277	3.64	No	Yes	0	8	9
166	R:R:N313	R:R:W277	11.3	Yes	Yes	3	9	9
167	R:R:P279	R:R:S278	3.56	No	No	0	9	7
168	R:R:F309	R:R:P279	4.33	No	No	0	7	9
169	R:R:F303	R:R:T283	3.89	No	No	0	4	5
170	R:R:L286	R:R:V297	8.94	No	No	1	5	4
171	R:R:I298	R:R:L286	4.28	Yes	No	1	3	5
172	R:R:I287	R:R:I298	7.36	No	Yes	1	5	3
173	R:R:I289	R:R:K293	11.63	No	No	0	4	1
174	R:R:I298	R:R:Q290	23.33	Yes	No	1	3	4
175	R:R:L296	R:R:W299	4.56	No	No	0	5	4
176	R:R:I298	R:R:V297	4.61	Yes	No	1	3	4
177	R:R:P300	R:R:W299	5.4	No	No	0	4	4
178	R:R:F303	R:R:V307	3.93	No	Yes	1	4	5
179	R:R:F304	R:R:W305	8.02	Yes	No	0	4	4
180	R:R:F311	R:R:V307	5.24	Yes	Yes	1	7	5
181	R:R:L316	R:R:N313	4.12	No	Yes	3	6	9
182	R:R:N313	R:R:N317	6.81	Yes	No	0	9	9
183	R:R:L316	R:R:L320	6.92	No	No	0	6	8
184	R:R:N322	R:R:T324	7.31	No	No	0	7	7
185	R:R:R152	R:R:R69	3.2	No	No	0	3	7
186	R:R:T101	R:R:V98	3.17	No	No	0	4	5
187	R:R:C174	R:R:L171	3.17	No	No	0	4	5
188	R:R:A131	R:R:L77	3.15	No	No	0	7	7
189	R:R:M137	R:R:S226	3.07	Yes	Yes	0	8	5
190	R:R:I233	R:R:V141	3.07	No	No	0	5	6
191	R:R:I193	R:R:T195	3.04	Yes	No	0	4	4
192	R:R:G72	R:R:R71	3	Yes	No	0	7	7
193	R:R:L320	R:R:S272	3	No	No	0	8	6
194	R:R:I275	R:R:M276	2.92	No	Yes	0	5	8
195	R:R:F82	R:R:P318	2.89	Yes	No	0	9	9
196	R:R:K235	R:R:K239	2.87	No	No	0	5	5
197	R:R:I162	R:R:N80	2.83	No	Yes	0	7	9
198	R:R:K235	R:R:L231	2.82	No	No	0	5	6
199	R:R:H142	R:R:V141	2.77	No	No	0	5	6
200	R:R:A169	R:R:F211	2.77	No	Yes	0	5	5
201	R:R:D259	R:R:K235	2.77	No	No	0	7	5
202	R:R:H251	R:R:V255	2.77	Yes	No	0	2	5
203	R:R:L268	R:R:L269	2.77	No	No	0	6	8
204	R:R:L127	R:R:N215	2.75	No	Yes	0	6	6
205	R:R:I233	R:R:Q232	2.74	No	No	0	5	4
206	R:R:R178	R:R:V180	2.62	No	No	0	4	4
207	R:R:T242	R:R:Y247	2.5	No	Yes	0	4	4
208	R:R:F51	R:R:L55	2.44	No	No	0	6	5
209	R:R:T44	R:R:W100	2.43	Yes	No	0	6	5
210	R:R:L77	R:R:R155	2.43	No	Yes	0	7	6
211	R:R:L113	R:R:Y116	2.34	No	No	0	5	5
212	R:R:Q144	R:R:R145	2.34	No	No	0	6	5
213	R:R:Q258	R:R:R238	2.34	No	No	0	6	4
214	R:R:F263	R:R:F267	2.14	No	No	0	7	5
215	R:R:C60	R:R:G57	1.96	No	No	0	6	9
216	R:R:A73	R:R:G72	1.95	No	Yes	0	6	7
217	R:R:A154	R:R:G151	1.95	No	No	0	5	7
218	R:R:A167	R:R:G164	1.95	No	No	0	3	4
219	R:R:A130	R:R:P219	1.87	No	No	0	7	9
220	R:R:G203	R:R:S206	1.86	No	No	0	3	4
221	R:R:G33	R:R:V31	1.84	No	No	0	3	6
222	R:R:G72	R:R:T74	1.82	Yes	No	0	7	8
223	R:R:P181	R:R:S192	1.78	No	No	0	2	3
224	R:R:P279	R:R:V306	1.77	No	No	0	9	6
225	R:R:C76	R:R:V65	1.71	No	No	0	5	7
226	R:R:A315	R:R:V53	1.7	No	No	0	6	5
227	R:R:A84	R:R:V124	1.7	No	No	0	8	7
228	R:R:A91	R:R:V117	1.7	No	No	0	6	4
229	R:R:A41	R:R:T44	1.68	No	Yes	0	3	6
230	R:R:C139	R:R:I140	1.64	No	No	0	8	8
231	R:R:A103	R:R:I191	1.62	No	No	0	5	4
232	R:R:S192	R:R:V179	1.62	No	No	0	3	5
233	R:R:S228	R:R:V224	1.62	No	No	0	3	5
234	R:R:S256	R:R:V255	1.62	No	No	0	4	5
235	R:R:A40	R:R:K32	1.61	No	No	0	5	3
236	R:R:A312	R:R:M276	1.61	No	Yes	0	5	8
237	R:R:V42	R:R:V46	1.6	No	No	0	5	6
238	R:R:T45	R:R:V46	1.59	No	No	0	4	6
239	R:R:T213	R:R:V209	1.59	No	No	0	5	4
240	R:R:T213	R:R:V212	1.59	No	No	0	5	6
241	R:R:A40	R:R:L37	1.58	No	No	0	5	3
242	R:R:A110	R:R:L94	1.58	No	No	0	5	5
243	R:R:A110	R:R:L106	1.58	No	No	0	5	6
244	R:R:A167	R:R:L120	1.58	No	No	0	3	5
245	R:R:A131	R:R:L158	1.58	No	No	0	7	5
246	R:R:T44	R:R:T45	1.57	Yes	No	0	6	4
247	R:R:C83	R:R:N80	1.57	No	Yes	0	5	9
248	R:R:E190	R:R:P181	1.57	No	No	0	3	2
249	R:R:A61	R:R:N322	1.56	No	No	0	8	7
250	R:R:I282	R:R:S278	1.55	No	No	0	5	7
251	R:R:I50	R:R:V46	1.54	No	No	0	7	6
252	R:R:I275	R:R:V271	1.54	No	No	0	5	5
253	R:R:C139	R:R:Q144	1.53	No	No	0	8	6
254	R:R:C139	R:R:E135	1.52	No	No	0	8	8
255	R:R:A40	R:R:E43	1.51	No	Yes	0	5	5
256	R:R:M323	R:R:T265	1.51	No	No	0	5	8
257	R:R:G72	R:R:R68	1.5	Yes	No	0	7	6
258	R:R:L87	R:R:S90	1.5	No	No	0	6	4
259	R:R:L134	R:R:S226	1.5	No	Yes	0	5	5
260	R:R:G151	R:R:R155	1.5	No	Yes	0	7	6
261	R:R:L39	R:R:V38	1.49	No	No	0	4	3
262	R:R:L39	R:R:V42	1.49	No	No	0	4	5
263	R:R:L96	R:R:V48	1.49	No	No	0	6	4
264	R:R:L49	R:R:V53	1.49	No	No	0	4	5
265	R:R:L64	R:R:V63	1.49	No	No	0	7	4
266	R:R:I201	R:R:I205	1.47	No	No	0	4	4
267	R:R:L217	R:R:T213	1.47	No	No	0	4	5
268	R:R:D30	R:R:V31	1.46	No	No	0	6	6
269	R:R:Q258	R:R:V255	1.43	No	No	0	6	5
270	R:R:I289	R:R:L286	1.43	No	No	0	4	5
271	R:R:L268	R:R:M323	1.41	No	No	0	6	5
272	R:R:H251	R:R:S248	1.39	Yes	No	0	2	6
273	R:R:D295	R:R:K293	1.38	No	No	0	3	1
274	R:R:L64	R:R:N322	1.37	No	No	0	7	7
275	R:R:R254	R:R:S250	1.32	No	No	0	4	5
276	R:R:A308	R:R:W305	1.3	No	No	0	4	4
277	R:R:E190	R:R:Q189	1.27	No	No	0	3	1
278	R:R:S301	R:R:W305	1.24	No	No	0	2	4
279	R:R:Q257	R:R:R261	1.17	No	No	0	5	8
280	R:R:L302	R:R:W299	1.14	No	No	0	5	4
281	R:R:R261	R:R:R264	1.07	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.31545	11	1	0
2	R:R:F25	8.584	5	1	5
3	R:R:P26	5.67	4	1	5
4	R:R:F28	7.958	5	1	8
5	R:R:E43	7.35333	6	1	5
6	R:R:T44	3.89	4	0	6
7	R:R:G72	2.0675	4	0	7
8	R:R:N80	6.28	5	0	9
9	R:R:F82	5.16	5	0	9
10	R:R:D85	6.66	4	0	9
11	R:R:F88	6.388	5	1	7
12	R:R:W104	10.585	4	4	9
13	R:R:F115	6.622	5	0	5
14	R:R:M118	4.2225	4	1	7
15	R:R:M137	5.16	4	0	8
16	R:R:R155	4.8025	4	0	6
17	R:R:I193	6.095	4	1	4
18	R:R:L196	6.9875	4	0	5
19	R:R:W198	7.966	5	0	7
20	R:R:W207	9.2325	4	0	6
21	R:R:F211	9.375	4	0	5
22	R:R:N215	7.43	4	0	6
23	R:R:S226	3.6375	4	2	5
24	R:R:Y227	6.14429	7	2	9
25	R:R:Y247	5.6975	4	0	4
26	R:R:H251	5.765	4	0	2
27	R:R:F273	5.7425	4	3	9
28	R:R:M276	5.49	5	3	8
29	R:R:W277	8.26	4	3	9
30	R:R:I298	11.684	5	1	3
31	R:R:F304	9.986	5	1	4
32	R:R:V307	4.605	4	1	5
33	R:R:F311	5.42	4	1	7
34	R:R:N313	8.3625	4	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I287	17.5946	3.84	Yes	No	1	0	5
2	L:L:?1	R:R:V307	32.6968	4.01	Yes	Yes	1	0	5
3	R:R:F28	R:R:V307	46.5227	5.24	Yes	Yes	1	8	5
4	R:R:F28	R:R:F304	67.3125	6.43	Yes	Yes	1	8	4
5	R:R:E43	R:R:F304	43.0454	8.16	Yes	Yes	1	5	4
6	R:R:E43	R:R:T44	27.8507	9.88	Yes	Yes	0	5	6
7	R:R:T44	R:R:T45	21.0117	1.57	Yes	No	0	6	4
8	R:R:T45	R:R:V46	18.7136	1.59	No	No	0	4	6
9	R:R:V42	R:R:V46	14.0895	1.6	No	No	0	5	6
10	R:R:L39	R:R:V42	11.7636	1.49	No	No	0	4	5
11	L:L:?1	R:R:F88	50.1017	3.28	Yes	Yes	1	0	7
12	R:R:F311	R:R:F88	27.5964	6.43	Yes	Yes	1	7	7
13	R:R:F311	R:R:I92	15.6016	6.28	Yes	No	0	7	7
14	R:R:F51	R:R:I92	12.1983	6.28	No	No	0	6	7
15	R:R:F311	R:R:V307	23.5873	5.24	Yes	Yes	1	7	5
16	R:R:F88	R:R:S314	100	7.93	Yes	No	0	7	9
17	R:R:D85	R:R:S314	99.6255	8.83	Yes	No	0	9	9
18	R:R:D85	R:R:N58	20.873	5.39	Yes	No	0	9	9
19	R:R:F82	R:R:N58	18.2096	7.25	Yes	No	0	9	9
20	R:R:D85	R:R:N317	91.6351	8.08	Yes	No	0	9	9
21	R:R:L81	R:R:N317	25.9133	9.61	No	No	0	9	9
22	R:R:L81	R:R:T128	24.711	5.9	No	No	0	9	8
23	R:R:N80	R:R:T128	23.555	5.85	Yes	No	0	9	8
24	R:R:L159	R:R:N80	21.9088	10.98	No	Yes	0	7	9
25	R:R:L159	R:R:L77	20.2626	4.15	No	No	0	7	7
26	R:R:L77	R:R:R155	15.2687	2.43	No	Yes	0	7	6
27	L:L:?1	R:R:F211	22.1955	9.83	Yes	Yes	0	0	5
28	R:R:F211	R:R:N215	16.7021	10.87	Yes	Yes	0	5	6
29	R:R:N215	R:R:S123	12.6699	4.47	Yes	No	0	6	6
30	R:R:S123	R:R:S166	11.9948	6.52	No	No	0	6	8
31	R:R:L120	R:R:S166	11.7451	6.01	No	No	0	5	8
32	R:R:L120	R:R:W163	11.2041	3.42	No	No	0	5	9
33	R:R:N80	R:R:W163	10.8157	10.17	Yes	No	0	9	9
34	R:R:F115	R:R:M118	35.2354	3.73	Yes	Yes	0	5	7
35	R:R:F115	R:R:L114	21.784	3.65	Yes	No	0	5	6
36	R:R:L114	R:R:L94	20.7204	5.54	No	No	0	6	5
37	R:R:A110	R:R:L94	19.6476	1.58	No	No	0	5	5
38	R:R:A110	R:R:L106	18.5656	1.58	No	No	0	5	6
39	R:R:L106	R:R:W104	17.4743	9.11	No	Yes	0	6	9
40	R:R:C194	R:R:W104	11.833	13.06	No	Yes	4	9	9
41	R:R:C194	R:R:V179	10.7325	5.12	No	No	0	9	5
42	L:L:?1	R:R:D208	12.0272	8.21	Yes	No	0	0	5
43	R:R:P172	R:R:W207	12.0179	9.46	No	Yes	0	8	6
44	R:R:N313	R:R:N317	83.1823	6.81	Yes	No	0	9	9
45	R:R:N313	R:R:W277	22.1909	11.3	Yes	Yes	3	9	9
46	R:R:F273	R:R:W277	12.5636	4.01	Yes	Yes	3	9	9
47	R:R:L316	R:R:N313	58.0597	4.12	No	Yes	3	6	9
48	R:R:L316	R:R:L320	59.0863	6.92	No	No	0	6	8
49	R:R:L269	R:R:L320	57.0332	4.15	No	No	0	8	8
50	R:R:L269	R:R:Y227	52.8161	8.21	No	Yes	0	8	9
51	R:R:S226	R:R:Y227	14.0063	5.09	Yes	Yes	2	5	9
52	R:R:M137	R:R:S226	11.3336	3.07	Yes	Yes	0	8	5
53	R:R:L266	R:R:Y227	29.5616	5.86	No	Yes	0	8	9
54	R:R:L231	R:R:L266	25.9133	4.15	No	No	0	6	8
55	R:R:K235	R:R:L231	22.0013	2.82	No	No	0	5	6
56	R:R:D259	R:R:K235	19.4442	2.77	No	No	0	7	5
57	R:R:D259	R:R:R238	18.2003	10.72	No	No	0	7	4
58	R:R:Q258	R:R:R238	15.4999	2.34	No	No	0	6	4
59	R:R:Q258	R:R:V255	14.1404	1.43	No	No	0	6	5
60	R:R:H251	R:R:V255	11.3844	2.77	Yes	No	0	2	5
61	R:R:M276	R:R:N313	10.7325	11.22	Yes	Yes	3	8	9
62	R:R:F88	R:R:M118	30.1165	3.73	Yes	Yes	1	7	7
63	R:R:F115	R:R:F28	24.9191	9.65	Yes	Yes	0	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F88	3.28	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M118	5.7	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T119	6.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:L173	4.65	1	Yes	No	0	5	0	1
L:L:?1	R:R:E204	7.13	1	Yes	No	0	5	0	1
L:L:?1	R:R:D208	8.21	1	Yes	No	0	5	0	1
L:L:?1	R:R:F211	9.83	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I280	18.24	1	Yes	No	0	6	0	1
L:L:?1	R:R:I284	8.64	1	Yes	No	0	5	0	1
L:L:?1	R:R:I287	3.84	1	Yes	No	0	5	0	1
L:L:?1	R:R:V307	4.01	1	Yes	Yes	0	5	0	1
R:R:F25	R:R:I287	5.02	1	Yes	No	5	5	2	1
R:R:F25	R:R:I298	18.84	1	Yes	Yes	5	3	2	2
R:R:F115	R:R:F28	9.65	0	Yes	Yes	5	8	2	2
R:R:F28	R:R:F303	5.36	1	Yes	No	8	4	2	2
R:R:F28	R:R:V307	5.24	1	Yes	Yes	8	5	2	1
R:R:F88	R:R:M118	3.73	1	Yes	Yes	7	7	1	1
R:R:F88	R:R:S121	10.57	1	Yes	No	7	8	1	2
R:R:F311	R:R:F88	6.43	1	Yes	Yes	7	7	2	1
R:R:F88	R:R:S314	7.93	1	Yes	No	7	9	1	2
R:R:F115	R:R:M118	3.73	0	Yes	Yes	5	7	2	1
R:R:F311	R:R:M118	3.73	1	Yes	Yes	7	7	2	1
R:R:A170	R:R:T119	3.36	0	No	No	7	5	2	1
R:R:L173	R:R:T119	5.9	1	No	No	5	5	1	1
R:R:L173	R:R:L196	4.15	1	No	Yes	5	5	1	2
R:R:L196	R:R:W198	7.97	0	Yes	Yes	5	7	2	2
R:R:E204	R:R:W198	14.17	0	No	Yes	5	7	1	2
R:R:W198	R:R:W207	5.62	0	Yes	Yes	7	6	2	2
R:R:E204	R:R:N291	9.2	0	No	No	5	2	1	2
R:R:D208	R:R:W207	7.82	0	No	Yes	5	6	1	2
R:R:F211	R:R:W207	14.03	0	Yes	Yes	5	6	1	2
R:R:D208	R:R:L288	6.79	0	No	No	5	4	1	2
R:R:F211	R:R:N215	10.87	0	Yes	Yes	5	6	1	2
R:R:I287	R:R:I298	7.36	1	No	Yes	5	3	1	2
R:R:F303	R:R:V307	3.93	1	No	Yes	4	5	2	1
R:R:F311	R:R:V307	5.24	1	Yes	Yes	7	5	2	1
R:R:A169	R:R:F211	2.77	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ID8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	263
Number of Links	281
Number of Hubs	34
Number of Links mediated by Hubs	131
Number of Communities	4
Number of Nodes involved in Communities	40
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	41561
Length Of Smallest Path	3
Average Path Length	13.4617
Length of Longest Path	32
Minimum Path Strength	1.12
Average Path Strength	6.12427
Maximum Path Strength	15.345
Minimum Path Correlation	0.7
Average Path Correlation	0.942492
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	61.9557
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.7207
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • arrestin family protein binding • fatty acid binding • organic acid binding • ion binding • anion binding • lipid binding • carboxylic acid binding • monocarboxylic acid binding • small molecule binding • taste receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of peptide secretion • transport • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion • somatostatin secretion • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of somatostatin secretion • peptide secretion • localization • secretion by cell • regulation of secretion by cell • negative regulation of secretion • amide transport • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of peptide hormone secretion • regulation of signaling • negative regulation of peptide hormone secretion • secretion • regulation of transport • regulation of hormone levels • regulation of peptide transport • export from cell • establishment of localization • regulation of secretion • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • hexose transmembrane transport • carbohydrate transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • ghrelin secretion • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of osteoblast differentiation • cellular developmental process • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • cell differentiation • fat cell differentiation • positive regulation of brown fat cell differentiation • positive regulation of fat cell differentiation • regulation of brown fat cell differentiation • brown fat cell differentiation • regulation of fat cell differentiation • glucagon secretion • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • regulation of glucagon secretion • positive regulation of peptide secretion • positive regulation of glucagon secretion • positive regulation of peptide hormone secretion • positive regulation of transport • white fat cell differentiation • intracellular vesicle • cytoplasmic vesicle • endocytic vesicle • ciliary membrane • plasma membrane region • cell projection membrane • endosome membrane • endosome • cytoplasmic vesicle membrane • vesicle membrane • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YN9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YN9
Name	3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid
Synonyms
Identifier
Formula	C23 H21 F O3
Molecular Weight	364.409
SMILES
PubChem	57522038
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	0
Total Bonds	50
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5NUL3
Sequence	>8ID8_nogp_Chain_R R T R F P F F S D V K G D H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R R R R G A T A C L V L N L F C A D L L F I S A I P L V L A V R W T E A W L L G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H L Q R G R R A R A V L L A L I W G Y S A V A A L P L C V F F R V V P Q Q E I S I C T L I W P I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L A Y S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q D L V I W P S L F F W V V A F T F A N S A L N P I L Y N M T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8T3Q	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.14	2024-01-24	10.1126/sciadv.adj2384
	8T3Q (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.14	2024-01-24	10.1126/sciadv.adj2384
	8T3O	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	2Y5	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.06	2024-01-17	10.1126/sciadv.adj2384
	8T3O (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	2Y5		3.06	2024-01-17	10.1126/sciadv.adj2384
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	10.1038/s41422-023-00835-x
	8IYS	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP	chim(NtGi1L-Gq)/β1/γ2	2.95	2023-06-21	10.1038/s41422-023-00835-x
	8IYS (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP		2.95	2023-06-21	10.1038/s41422-023-00835-x
	8ID9	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-	Gi1/β1/γ2	3	2023-03-15	10.1126/science.add6220
	8ID9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-		3	2023-03-15	10.1126/science.add6220
	8ID8	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	Gi1/β1/γ2	3	2023-03-15	10.1126/science.add6220
	8ID8 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3	2023-03-15	10.1126/science.add6220
	8ID6	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-	Gi1/β1/γ2	2.8	2023-03-15	10.1126/science.add6220
	8ID6 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-		2.8	2023-03-15	10.1126/science.add6220
	8ID4	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-	Gi1/β1/γ2	3.1	2023-03-15	10.1126/science.add6220
	8ID4 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-		3.1	2023-03-15	10.1126/science.add6220
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	10.1126/science.add6220
	8G59	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(Gi1-CtGq)/β1/γ2	2.64	2023-03-08	10.1126/science.add6220
	8G59 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		2.64	2023-03-08	10.1126/science.add6220

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