psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F27	5.52	Yes	No	0	0	5
2	L:L:?1	R:R:T119	8.01	Yes	No	0	0	5
3	L:L:?1	R:R:G122	4.65	Yes	No	0	0	7
4	L:L:?1	R:R:L196	3.76	Yes	No	0	0	5
5	L:L:?1	R:R:D208	14.76	Yes	Yes	1	0	5
6	L:L:?1	R:R:F211	4.41	Yes	No	0	0	5
7	L:L:?1	R:R:I280	14.23	Yes	No	0	0	6
8	L:L:?1	R:R:I281	5.17	Yes	No	0	0	7
9	L:L:?1	R:R:I284	6.47	Yes	No	1	0	5
10	L:L:?1	R:R:I287	5.17	Yes	No	0	0	5
11	L:L:?1	R:R:F303	5.52	Yes	Yes	1	0	4
12	R:R:R24	R:R:T195	5.17	No	No	0	5	4
13	R:R:I197	R:R:R24	8.77	No	No	0	4	5
14	R:R:F25	R:R:P26	7.22	Yes	No	0	5	5
15	R:R:F25	R:R:F27	5.36	Yes	No	0	5	5
16	R:R:F25	R:R:I287	7.54	Yes	No	0	5	5
17	R:R:F25	R:R:Q290	9.37	Yes	No	0	5	4
18	R:R:F25	R:R:I298	12.56	Yes	No	0	5	3
19	R:R:P26	R:R:S29	5.34	No	No	0	5	9
20	R:R:F177	R:R:F27	4.29	No	No	0	5	5
21	R:R:F28	R:R:V95	7.87	Yes	No	0	8	6
22	R:R:F115	R:R:F28	5.36	No	Yes	0	5	8
23	R:R:F28	R:R:F303	6.43	Yes	Yes	1	8	4
24	R:R:F28	R:R:V307	3.93	Yes	No	1	8	5
25	R:R:D30	R:R:K32	15.21	No	No	0	6	3
26	R:R:D30	R:R:R99	3.57	No	No	0	6	4
27	R:R:K32	R:R:L37	7.05	No	No	0	3	3
28	R:R:H35	R:R:V38	5.54	No	No	0	3	3
29	R:R:H35	R:R:L39	12.86	No	No	0	3	4
30	R:R:L37	R:R:R36	8.5	No	No	0	3	4
31	R:R:L37	R:R:W100	4.56	No	No	0	3	5
32	R:R:A40	R:R:W100	7.78	No	No	0	5	5
33	R:R:E43	R:R:V42	4.28	No	No	0	5	5
34	R:R:E43	R:R:F304	12.83	No	No	0	5	4
35	R:R:E43	R:R:W305	18.54	No	No	0	5	4
36	R:R:T44	R:R:W100	7.28	No	No	0	6	5
37	R:R:I92	R:R:L47	4.28	Yes	No	0	7	6
38	R:R:L47	R:R:L96	8.3	No	No	0	6	6
39	R:R:F304	R:R:L47	4.87	No	No	0	4	6
40	R:R:F51	R:R:L55	3.65	No	No	0	6	5
41	R:R:F51	R:R:I89	3.77	No	No	0	6	6
42	R:R:F51	R:R:I92	5.02	No	Yes	0	6	7
43	R:R:I89	R:R:S54	4.64	No	No	0	6	8
44	R:R:S314	R:R:S54	4.89	No	No	0	9	8
45	R:R:F82	R:R:N58	10.87	Yes	No	0	9	9
46	R:R:D85	R:R:N58	5.39	Yes	No	0	9	9
47	R:R:A61	R:R:F82	4.16	No	Yes	0	8	9
48	R:R:F82	R:R:L62	4.87	Yes	No	0	9	6
49	R:R:L64	R:R:N322	6.87	No	No	0	7	7
50	R:R:R68	R:R:R70	8.53	No	No	0	6	7
51	R:R:L325	R:R:R68	7.29	No	No	0	8	6
52	R:R:E135	R:R:T74	8.47	No	No	0	8	8
53	R:R:E135	R:R:L77	7.95	No	No	0	8	7
54	R:R:F82	R:R:V78	5.24	Yes	No	0	9	8
55	R:R:N80	R:R:T128	5.85	No	No	0	9	8
56	R:R:L159	R:R:N80	5.49	No	No	0	7	9
57	R:R:N80	R:R:W163	11.3	No	No	0	9	9
58	R:R:D85	R:R:L81	5.43	Yes	No	2	9	9
59	R:R:L81	R:R:T128	5.9	No	No	0	9	8
60	R:R:L81	R:R:N317	8.24	No	No	2	9	9
61	R:R:D85	R:R:T125	4.34	Yes	No	0	9	9
62	R:R:D85	R:R:S314	4.42	Yes	No	0	9	9
63	R:R:D85	R:R:N317	8.08	Yes	No	2	9	9
64	R:R:L87	R:R:S121	7.51	No	No	0	6	8
65	R:R:F88	R:R:S121	5.28	No	No	0	7	8
66	R:R:F88	R:R:W277	4.01	No	Yes	0	7	9
67	R:R:F311	R:R:F88	8.57	Yes	No	0	7	7
68	R:R:I92	R:R:P93	5.08	Yes	No	0	7	9
69	R:R:F311	R:R:I92	10.05	Yes	Yes	0	7	7
70	R:R:L114	R:R:L94	11.07	No	No	0	6	5
71	R:R:F304	R:R:R99	27.79	No	No	0	4	4
72	R:R:E102	R:R:T101	4.23	No	No	0	4	4
73	R:R:A103	R:R:E102	4.53	No	No	0	5	4
74	R:R:A103	R:R:I191	4.87	No	No	0	5	4
75	R:R:L106	R:R:W104	6.83	No	Yes	0	6	9
76	R:R:C111	R:R:W104	3.92	Yes	Yes	3	9	9
77	R:R:F115	R:R:W104	6.01	No	Yes	0	5	9
78	R:R:C194	R:R:W104	18.28	No	Yes	3	9	9
79	R:R:G107	R:R:P108	4.06	No	No	0	8	3
80	R:R:C111	R:R:H112	4.42	Yes	No	0	9	7
81	R:R:C111	R:R:C194	5.46	Yes	No	3	9	9
82	R:R:H112	R:R:R178	5.64	No	No	0	7	4
83	R:R:F115	R:R:L114	3.65	No	No	0	5	6
84	R:R:L114	R:R:M118	4.24	No	No	0	6	7
85	R:R:C174	R:R:Y116	9.41	No	No	0	4	5
86	R:R:F311	R:R:M118	4.98	Yes	No	0	7	7
87	R:R:L173	R:R:T119	4.42	No	No	0	5	5
88	R:R:L120	R:R:W163	4.56	No	No	0	5	9
89	R:R:L120	R:R:S166	4.5	No	No	0	5	8
90	R:R:N215	R:R:S123	4.47	No	No	0	6	6
91	R:R:V124	R:R:W163	8.58	No	No	0	7	9
92	R:R:T125	R:R:W277	3.64	No	Yes	0	9	9
93	R:R:F273	R:R:I126	5.02	Yes	No	0	9	8
94	R:R:I126	R:R:W277	11.74	No	Yes	0	8	9
95	R:R:L129	R:R:Y321	8.21	No	No	0	8	9
96	R:R:R136	R:R:V132	3.92	No	No	0	9	8
97	R:R:I223	R:R:S133	9.29	No	No	0	8	8
98	R:R:S133	R:R:S226	4.89	No	No	0	8	5
99	R:R:S133	R:R:Y227	10.17	No	Yes	0	8	9
100	R:R:L134	R:R:V222	5.96	No	No	0	5	6
101	R:R:E135	R:R:R155	13.96	No	No	0	8	6
102	R:R:R136	R:R:Y227	4.12	No	Yes	0	9	9
103	R:R:R136	R:R:Y321	4.12	No	No	0	9	9
104	R:R:M137	R:R:S226	4.6	Yes	No	0	8	5
105	R:R:K229	R:R:M137	8.64	No	Yes	0	5	8
106	R:R:I230	R:R:M137	4.37	No	Yes	0	8	8
107	R:R:C139	R:R:Q144	4.58	No	No	0	8	6
108	R:R:H142	R:R:V141	4.15	No	No	0	5	6
109	R:R:G146	R:R:R145	6	No	No	0	6	5
110	R:R:A169	R:R:Y165	5.34	No	No	0	5	4
111	R:R:L214	R:R:Y165	9.38	No	No	0	4	4
112	R:R:N215	R:R:Y165	11.63	No	No	0	6	4
113	R:R:P172	R:R:W207	12.16	No	Yes	0	8	6
114	R:R:L173	R:R:W207	9.11	No	Yes	0	5	6
115	R:R:F176	R:R:V175	6.55	No	No	0	5	4
116	R:R:F176	R:R:W198	9.02	No	Yes	0	5	7
117	R:R:F176	R:R:P199	10.11	No	No	0	5	6
118	R:R:F177	R:R:L196	13.4	No	No	0	5	5
119	R:R:P181	R:R:V180	5.3	No	No	0	2	4
120	R:R:I193	R:R:Q182	5.49	Yes	No	0	4	2
121	R:R:I193	R:R:T195	7.6	Yes	No	0	4	4
122	R:R:L196	R:R:W198	7.97	No	Yes	0	5	7
123	R:R:E204	R:R:W198	19.63	No	Yes	0	5	7
124	R:R:W198	R:R:W207	5.62	Yes	Yes	0	7	6
125	R:R:P202	R:R:T200	5.25	No	No	0	3	3
126	R:R:G203	R:R:T200	3.64	No	No	0	3	3
127	R:R:I201	R:R:P202	6.77	No	No	0	4	3
128	R:R:G203	R:R:S206	3.71	No	No	0	3	4
129	R:R:E204	R:R:L288	5.3	No	No	0	5	4
130	R:R:E204	R:R:N291	5.26	No	No	0	5	2
131	R:R:D208	R:R:W207	4.47	Yes	Yes	0	5	6
132	R:R:F211	R:R:W207	12.03	No	Yes	0	5	6
133	R:R:D208	R:R:I284	4.2	Yes	No	1	5	5
134	R:R:D208	R:R:L288	8.14	Yes	No	0	5	4
135	R:R:F211	R:R:N215	8.46	No	No	0	5	6
136	R:R:I281	R:R:V212	4.61	No	No	0	7	6
137	R:R:L285	R:R:V212	4.47	No	No	0	6	6
138	R:R:L217	R:R:T213	8.84	No	No	0	4	5
139	R:R:L214	R:R:V218	5.96	No	No	0	4	5
140	R:R:F216	R:R:F273	4.29	No	Yes	0	8	9
141	R:R:F216	R:R:I281	16.33	No	No	0	8	7
142	R:R:P219	R:R:V218	7.07	No	No	0	9	5
143	R:R:F273	R:R:G220	4.52	Yes	No	0	9	6
144	R:R:F273	R:R:I223	3.77	Yes	No	0	9	8
145	R:R:L269	R:R:Y227	9.38	No	Yes	0	8	9
146	R:R:M270	R:R:Y227	9.58	No	Yes	0	8	9
147	R:R:F263	R:R:L231	4.87	No	No	0	7	6
148	R:R:L231	R:R:L266	5.54	No	No	0	6	8
149	R:R:L262	R:R:T234	4.42	No	No	0	8	8
150	R:R:R238	R:R:Y247	9.26	No	Yes	0	4	4
151	R:R:D259	R:R:R238	14.29	No	No	0	7	4
152	R:R:L241	R:R:Y247	7.03	No	Yes	0	5	4
153	R:R:T242	R:R:Y247	4.99	No	Yes	0	4	4
154	R:R:H251	R:R:Y247	7.62	No	Yes	0	2	4
155	R:R:V255	R:R:Y247	5.05	No	Yes	0	5	4
156	R:R:H251	R:R:R254	6.77	No	No	0	2	4
157	R:R:L262	R:R:L266	4.15	No	No	0	8	8
158	R:R:F273	R:R:F274	8.57	Yes	No	0	9	6
159	R:R:F309	R:R:M276	6.22	No	Yes	0	7	8
160	R:R:M276	R:R:N313	9.82	Yes	No	0	8	9
161	R:R:L316	R:R:M276	4.24	No	Yes	0	6	8
162	R:R:T310	R:R:W277	3.64	No	Yes	0	8	9
163	R:R:N313	R:R:W277	16.95	No	Yes	0	9	9
164	R:R:F309	R:R:P279	7.22	No	No	0	7	9
165	R:R:I280	R:R:T310	4.56	No	No	0	6	8
166	R:R:L286	R:R:T283	5.9	No	Yes	0	5	5
167	R:R:F303	R:R:T283	5.19	Yes	Yes	0	4	5
168	R:R:I298	R:R:L286	4.28	No	No	0	3	5
169	R:R:I289	R:R:K293	4.36	No	No	0	4	1
170	R:R:F292	R:R:N291	10.87	No	No	0	1	2
171	R:R:K293	R:R:V297	4.55	No	No	0	1	4
172	R:R:I298	R:R:L302	7.14	No	No	0	3	5
173	R:R:P300	R:R:W299	5.4	No	No	0	4	4
174	R:R:F303	R:R:V307	3.93	Yes	No	1	4	5
175	R:R:F311	R:R:V307	6.55	Yes	No	0	7	5
176	R:R:N313	R:R:N317	6.81	No	No	0	9	9
177	R:R:L316	R:R:L320	6.92	No	Yes	0	6	8
178	R:R:L325	R:R:N322	5.49	No	No	0	8	7
179	R:R:P279	R:R:S278	3.56	No	No	0	9	7
180	R:R:L266	R:R:Y227	3.52	No	Yes	0	8	9
181	R:R:A315	R:R:S54	3.42	No	No	0	6	8
182	R:R:A84	R:R:T125	3.36	No	No	0	8	9
183	R:R:A170	R:R:T119	3.36	No	No	0	7	5
184	R:R:L171	R:R:P172	3.28	No	No	0	5	8
185	R:R:N58	R:R:P318	3.26	No	No	0	9	9
186	R:R:S192	R:R:V179	3.23	No	No	0	3	5
187	R:R:R70	R:R:R71	3.2	No	No	0	7	7
188	R:R:R261	R:R:R264	3.2	No	No	0	8	7
189	R:R:T101	R:R:V98	3.17	No	No	0	4	5
190	R:R:C174	R:R:L171	3.17	No	No	0	4	5
191	R:R:T283	R:R:V306	3.17	Yes	No	0	5	6
192	R:R:A246	R:R:L241	3.15	No	No	0	4	5
193	R:R:I50	R:R:V46	3.07	No	No	0	7	6
194	R:R:I193	R:R:V180	3.07	Yes	No	0	4	4
195	R:R:M137	R:R:V141	3.04	Yes	No	0	8	6
196	R:R:M323	R:R:T265	3.01	No	No	0	5	8
197	R:R:G72	R:R:R71	3	No	No	0	7	7
198	R:R:L127	R:R:S123	3	No	No	0	6	6
199	R:R:L320	R:R:S272	3	Yes	No	0	8	6
200	R:R:L64	R:R:V65	2.98	No	No	0	7	7
201	R:R:L79	R:R:V65	2.98	No	No	0	5	7
202	R:R:L87	R:R:V117	2.98	No	No	0	6	4
203	R:R:L77	R:R:T128	2.95	No	No	0	7	8
204	R:R:I140	R:R:I230	2.94	No	No	0	8	8
205	R:R:I191	R:R:I193	2.94	No	Yes	0	4	4
206	R:R:I89	R:R:L86	2.85	No	No	0	6	7
207	R:R:I162	R:R:L127	2.85	No	No	0	7	6
208	R:R:I162	R:R:L158	2.85	No	No	0	7	5
209	R:R:I205	R:R:L288	2.85	No	No	0	4	4
210	R:R:Q252	R:R:T242	2.83	No	No	0	2	4
211	R:R:L268	R:R:M323	2.83	No	No	0	6	5
212	R:R:L62	R:R:L79	2.77	No	No	0	6	5
213	R:R:L268	R:R:L320	2.77	No	Yes	0	6	8
214	R:R:R240	R:R:S237	2.64	No	No	0	3	6
215	R:R:R254	R:R:S250	2.64	No	No	0	4	5
216	R:R:F274	R:R:V224	2.62	No	No	0	6	5
217	R:R:F267	R:R:V271	2.62	No	No	0	5	5
218	R:R:A110	R:R:W104	2.59	No	Yes	0	5	9
219	R:R:A308	R:R:W305	2.59	No	No	0	4	4
220	R:R:V46	R:R:W305	2.45	No	No	0	6	4
221	R:R:A73	R:R:G72	1.95	No	No	0	6	7
222	R:R:A130	R:R:P219	1.87	No	No	0	7	9
223	R:R:P108	R:R:V179	1.77	No	No	0	3	5
224	R:R:G57	R:R:L56	1.71	No	No	0	9	4
225	R:R:C60	R:R:V59	1.71	No	No	0	6	3
226	R:R:A103	R:R:S192	1.71	No	No	0	5	3
227	R:R:G107	R:R:L106	1.71	No	No	0	8	6
228	R:R:C111	R:R:V179	1.71	Yes	No	0	9	5
229	R:R:A315	R:R:V53	1.7	No	No	0	6	5
230	R:R:A91	R:R:V117	1.7	No	No	0	6	4
231	R:R:A130	R:R:V222	1.7	No	No	0	7	6
232	R:R:D34	R:R:G33	1.68	No	No	0	3	3
233	R:R:A41	R:R:T44	1.68	No	No	0	3	6
234	R:R:A312	R:R:I50	1.62	No	No	0	5	7
235	R:R:S256	R:R:V255	1.62	No	No	0	4	5
236	R:R:T45	R:R:V42	1.59	No	No	0	4	5
237	R:R:C76	R:R:L159	1.59	No	No	0	5	7
238	R:R:C83	R:R:L86	1.59	No	No	0	5	7
239	R:R:T213	R:R:V209	1.59	No	No	0	5	4
240	R:R:A131	R:R:L77	1.58	No	No	0	7	7
241	R:R:A167	R:R:L120	1.58	No	No	0	3	5
242	R:R:A131	R:R:L158	1.58	No	No	0	7	5
243	R:R:I205	R:R:S206	1.55	No	No	0	4	4
244	R:R:I233	R:R:V141	1.54	No	No	0	5	6
245	R:R:I205	R:R:V209	1.54	No	No	0	4	4
246	R:R:I282	R:R:T283	1.52	No	Yes	0	5	5
247	R:R:M323	R:R:T324	1.51	No	No	0	5	7
248	R:R:L49	R:R:T45	1.47	No	No	0	4	4
249	R:R:L105	R:R:T101	1.47	No	No	0	4	4
250	R:R:D30	R:R:V31	1.46	No	No	0	6	6
251	R:R:I275	R:R:M276	1.46	No	Yes	0	5	8
252	R:R:D295	R:R:V297	1.46	No	No	0	3	4
253	R:R:D259	R:R:T234	1.45	No	No	0	7	8
254	R:R:E249	R:R:S250	1.44	No	No	0	4	5
255	R:R:I289	R:R:L286	1.43	No	No	0	4	5
256	R:R:I319	R:R:L320	1.43	No	Yes	0	7	8
257	R:R:H251	R:R:S248	1.39	No	No	0	2	6
258	R:R:A75	R:R:R69	1.38	No	No	0	8	7
259	R:R:H142	R:R:V138	1.38	No	No	0	5	4
260	R:R:A154	R:R:R155	1.38	No	No	0	5	6
261	R:R:D34	R:R:L39	1.36	No	No	0	3	4
262	R:R:R99	R:R:S301	1.32	No	No	0	4	2
263	R:R:R67	R:R:V63	1.31	No	No	0	6	4
264	R:R:D295	R:R:Q294	1.31	No	No	0	3	1
265	R:R:R22	R:R:T23	1.29	No	No	0	5	8
266	R:R:R261	R:R:T324	1.29	No	No	0	8	7
267	R:R:E190	R:R:R183	1.16	No	No	0	3	3
268	R:R:L302	R:R:W299	1.14	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.06091	11	1	0
2	R:R:F25	8.41	5	0	5
3	R:R:F28	5.8975	4	1	8
4	R:R:F82	6.285	4	0	9
5	R:R:D85	5.532	5	2	9
6	R:R:I92	6.1075	4	0	7
7	R:R:W104	7.526	5	3	9
8	R:R:C111	3.8775	4	3	9
9	R:R:M137	5.1625	4	0	8
10	R:R:I193	4.775	4	0	4
11	R:R:W198	10.56	4	0	7
12	R:R:W207	8.678	5	0	6
13	R:R:D208	7.8925	4	1	5
14	R:R:Y227	7.354	5	0	9
15	R:R:Y247	6.79	5	0	4
16	R:R:F273	5.234	5	0	9
17	R:R:M276	5.435	4	0	8
18	R:R:W277	7.996	5	0	9
19	R:R:T283	3.945	4	0	5
20	R:R:F303	5.2675	4	1	4
21	R:R:F311	7.5375	4	0	7
22	R:R:L320	3.53	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F303	86.0977	5.52	Yes	Yes	1	0	4
2	R:R:F28	R:R:F303	40.2662	6.43	Yes	Yes	1	8	4
3	R:R:F115	R:R:F28	69.7646	5.36	No	Yes	0	5	8
4	R:R:F115	R:R:W104	96.4584	6.01	No	Yes	0	5	9
5	R:R:C111	R:R:W104	73.9881	3.92	Yes	Yes	3	9	9
6	R:R:C111	R:R:V179	63.0114	1.71	Yes	No	0	9	5
7	R:R:S192	R:R:V179	55.7303	3.23	No	No	0	3	5
8	R:R:A103	R:R:S192	51.8918	1.71	No	No	0	5	3
9	R:R:A103	R:R:I191	32.3691	4.87	No	No	0	5	4
10	R:R:I191	R:R:I193	28.3986	2.94	No	Yes	0	4	4
11	R:R:I193	R:R:T195	12.2965	7.6	Yes	No	0	4	4
12	L:L:?1	R:R:F27	24.1091	5.52	Yes	No	0	0	5
13	R:R:F25	R:R:F27	19.8526	5.36	Yes	No	0	5	5
14	R:R:F25	R:R:P26	11.7796	7.22	Yes	No	0	5	5
15	L:L:?1	R:R:I287	21.4804	5.17	Yes	No	0	0	5
16	R:R:F25	R:R:I287	18.9177	7.54	Yes	No	0	5	5
17	R:R:F25	R:R:I298	16.553	12.56	Yes	No	0	5	3
18	L:L:?1	R:R:L196	22.2063	3.76	Yes	No	0	0	5
19	R:R:F303	R:R:V307	44.9516	3.93	Yes	No	1	4	5
20	R:R:F311	R:R:V307	78.9265	6.55	Yes	No	0	7	5
21	R:R:F311	R:R:I92	88.4294	10.05	Yes	Yes	0	7	7
22	R:R:I92	R:R:L47	77.6617	4.28	Yes	No	0	7	6
23	R:R:F304	R:R:L47	71.3374	4.87	No	No	0	4	6
24	R:R:F304	R:R:R99	38.5394	27.79	No	No	0	4	4
25	R:R:D30	R:R:R99	31.8632	3.57	No	No	0	6	4
26	R:R:D30	R:R:K32	24.934	15.21	No	No	0	6	3
27	R:R:K32	R:R:L37	21.4364	7.05	No	No	0	3	3
28	R:R:L37	R:R:W100	14.3753	4.56	No	No	0	3	5
29	R:R:E43	R:R:F304	31.8632	12.83	No	No	0	5	4
30	R:R:E43	R:R:V42	10.8117	4.28	No	No	0	5	5
31	R:R:E43	R:R:W305	17.9168	18.54	No	No	0	5	4
32	R:R:F51	R:R:I92	28.1786	5.02	No	Yes	0	6	7
33	R:R:F51	R:R:I89	23.9991	3.77	No	No	0	6	6
34	L:L:?1	R:R:I280	65.9481	14.23	Yes	No	0	0	6
35	R:R:I280	R:R:T310	65.5631	4.56	No	No	0	6	8
36	R:R:T310	R:R:W277	66.0581	3.64	No	Yes	0	8	9
37	R:R:T125	R:R:W277	93.1258	3.64	No	Yes	0	9	9
38	R:R:D85	R:R:T125	88.6604	4.34	Yes	No	0	9	9
39	R:R:D85	R:R:S314	22.1183	4.42	Yes	No	0	9	9
40	R:R:S314	R:R:S54	20.3696	4.89	No	No	0	9	8
41	R:R:I89	R:R:S54	20.2706	4.64	No	No	0	6	8
42	R:R:D85	R:R:N58	53.4866	5.39	Yes	No	0	9	9
43	R:R:F82	R:R:N58	47.1073	10.87	Yes	No	0	9	9
44	R:R:F82	R:R:L62	37.3735	4.87	Yes	No	0	9	6
45	R:R:L62	R:R:L79	34.0849	2.77	No	No	0	6	5
46	R:R:L79	R:R:V65	30.7743	2.98	No	No	0	5	7
47	R:R:L64	R:R:V65	27.4417	2.98	No	No	0	7	7
48	R:R:L64	R:R:N322	24.0871	6.87	No	No	0	7	7
49	R:R:L325	R:R:N322	20.7105	5.49	No	No	0	8	7
50	R:R:L325	R:R:R68	17.3119	7.29	No	No	0	8	6
51	R:R:R68	R:R:R70	13.8913	8.53	No	No	0	6	7
52	L:L:?1	R:R:F211	47.2723	4.41	Yes	No	0	0	5
53	R:R:F211	R:R:N215	38.6494	8.46	No	No	0	5	6
54	R:R:N215	R:R:S123	16.872	4.47	No	No	0	6	6
55	R:R:L127	R:R:S123	14.6062	3	No	No	0	6	6
56	R:R:I162	R:R:L127	12.8245	2.85	No	No	0	7	6
57	R:R:I162	R:R:L158	11.4276	2.85	No	No	0	7	5
58	R:R:A131	R:R:L158	11.9666	1.58	No	No	0	7	5
59	R:R:A131	R:R:L77	13.3744	1.58	No	No	0	7	7
60	R:R:E135	R:R:L77	24.879	7.95	No	No	0	8	7
61	R:R:D85	R:R:L81	47.7123	5.43	Yes	No	2	9	9
62	R:R:L81	R:R:T128	82.7651	5.9	No	No	0	9	8
63	R:R:L77	R:R:T128	34.6568	2.95	No	No	0	7	8
64	R:R:N313	R:R:W277	80.6973	16.95	No	Yes	0	9	9
65	R:R:N313	R:R:N317	47.2503	6.81	No	No	0	9	9
66	R:R:L81	R:R:N317	40.5411	8.24	No	No	2	9	9
67	R:R:N80	R:R:T128	47.2393	5.85	No	No	0	9	8
68	R:R:L159	R:R:N80	11.9336	5.49	No	No	0	7	9
69	R:R:N80	R:R:W163	29.6854	11.3	No	No	0	9	9
70	R:R:F88	R:R:W277	100	4.01	No	Yes	0	7	9
71	R:R:F88	R:R:S121	16.0031	5.28	No	No	0	7	8
72	R:R:L87	R:R:S121	12.0326	7.51	No	No	0	6	8
73	R:R:F311	R:R:F88	98.9551	8.57	Yes	No	0	7	7
74	R:R:F115	R:R:L114	33.8759	3.65	No	No	0	5	6
75	R:R:A103	R:R:E102	16.355	4.53	No	No	0	5	4
76	R:R:E102	R:R:T101	12.2965	4.23	No	No	0	4	4
77	R:R:L106	R:R:W104	11.8896	6.83	No	Yes	0	6	9
78	R:R:F311	R:R:M118	37.1315	4.98	Yes	No	0	7	7
79	L:L:?1	R:R:D208	49.4281	14.76	Yes	Yes	1	0	5
80	R:R:D208	R:R:W207	15.1672	4.47	Yes	Yes	0	5	6
81	R:R:P172	R:R:W207	21.3704	12.16	No	Yes	0	8	6
82	R:R:L171	R:R:P172	16.0581	3.28	No	No	0	5	8
83	R:R:C174	R:R:L171	10.7237	3.17	No	No	0	4	5
84	R:R:F211	R:R:W207	17.6419	12.03	No	Yes	0	5	6
85	R:R:L120	R:R:W163	17.8729	4.56	No	No	0	5	9
86	L:L:?1	R:R:I281	60.5037	5.17	Yes	No	0	0	7
87	R:R:F216	R:R:I281	56.6102	16.33	No	No	0	8	7
88	R:R:F216	R:R:F273	56.6652	4.29	No	Yes	0	8	9
89	R:R:I126	R:R:W277	60.6907	11.74	No	Yes	0	8	9
90	R:R:F273	R:R:I126	59.1399	5.02	Yes	No	0	9	8
91	R:R:F273	R:R:I223	97.6243	3.77	Yes	No	0	9	8
92	R:R:I223	R:R:S133	95.3696	9.29	No	No	0	8	8
93	R:R:S133	R:R:Y227	71.7554	10.17	No	Yes	0	8	9
94	R:R:R136	R:R:Y227	12.0436	4.12	No	Yes	0	9	9
95	R:R:S133	R:R:S226	26.4518	4.89	No	No	0	8	5
96	R:R:N215	R:R:Y165	22.9542	11.63	No	No	0	6	4
97	R:R:L214	R:R:Y165	17.3449	9.38	No	No	0	4	4
98	R:R:L214	R:R:V218	14.5073	5.96	No	No	0	4	5
99	R:R:P219	R:R:V218	11.6476	7.07	No	No	0	9	5
100	R:R:E135	R:R:R155	12.4725	13.96	No	No	0	8	6
101	R:R:M137	R:R:S226	23.5812	4.6	Yes	No	0	8	5
102	R:R:M137	R:R:V141	11.8786	3.04	Yes	No	0	8	6
103	R:R:L196	R:R:W198	18.0158	7.97	No	Yes	0	5	7
104	R:R:D208	R:R:L288	37.9344	8.14	Yes	No	0	5	4
105	R:R:I205	R:R:L288	28.5966	2.85	No	No	0	4	4
106	R:R:I205	R:R:S206	16.1021	1.55	No	No	0	4	4
107	R:R:G203	R:R:S206	12.9234	3.71	No	No	0	3	4
108	R:R:E204	R:R:N291	10.8117	5.26	No	No	0	5	2
109	R:R:L266	R:R:Y227	53.8165	3.52	No	Yes	0	8	9
110	R:R:L262	R:R:L266	45.7985	4.15	No	No	0	8	8
111	R:R:L262	R:R:T234	43.0708	4.42	No	No	0	8	8
112	R:R:D259	R:R:T234	40.4641	1.45	No	No	0	7	8
113	R:R:D259	R:R:R238	37.7035	14.29	No	No	0	7	4
114	R:R:R238	R:R:Y247	35.0748	9.26	No	Yes	0	4	4
115	R:R:H251	R:R:Y247	15.0022	7.62	No	Yes	0	2	4
116	R:R:M276	R:R:N313	46.0185	9.82	Yes	No	0	8	9
117	R:R:L316	R:R:M276	31.1703	4.24	No	Yes	0	6	8
118	R:R:F303	R:R:T283	34.5909	5.19	Yes	Yes	0	4	5
119	R:R:L286	R:R:T283	24.5381	5.9	No	Yes	0	5	5
120	R:R:I289	R:R:L286	18.2468	1.43	No	No	0	4	5
121	R:R:I289	R:R:K293	14.6392	4.36	No	No	0	4	1
122	R:R:K293	R:R:V297	11.0097	4.55	No	No	0	1	4
123	R:R:I298	R:R:L302	14.7382	7.14	No	No	0	3	5
124	R:R:L316	R:R:L320	28.1346	6.92	No	Yes	0	6	8
125	R:R:R70	R:R:R71	10.4487	3.2	No	No	0	7	7
126	R:R:L268	R:R:L320	18.8957	2.77	No	Yes	0	6	8
127	R:R:L268	R:R:M323	15.7721	2.83	No	No	0	6	5
128	R:R:V46	R:R:W305	10.8117	2.45	No	No	0	6	4
129	R:R:F28	R:R:V307	33.8209	3.93	Yes	No	1	8	5
130	R:R:L114	R:R:M118	34.7558	4.24	No	No	0	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F27	5.52	1	Yes	No	0	5	0	1
L:L:?1	R:R:T119	8.01	1	Yes	No	0	5	0	1
L:L:?1	R:R:G122	4.65	1	Yes	No	0	7	0	1
L:L:?1	R:R:L196	3.76	1	Yes	No	0	5	0	1
L:L:?1	R:R:D208	14.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F211	4.41	1	Yes	No	0	5	0	1
L:L:?1	R:R:I280	14.23	1	Yes	No	0	6	0	1
L:L:?1	R:R:I281	5.17	1	Yes	No	0	7	0	1
L:L:?1	R:R:I284	6.47	1	Yes	No	0	5	0	1
L:L:?1	R:R:I287	5.17	1	Yes	No	0	5	0	1
L:L:?1	R:R:F303	5.52	1	Yes	Yes	0	4	0	1
R:R:F25	R:R:F27	5.36	0	Yes	No	5	5	2	1
R:R:F25	R:R:I287	7.54	0	Yes	No	5	5	2	1
R:R:F177	R:R:F27	4.29	0	No	No	5	5	2	1
R:R:F28	R:R:F303	6.43	1	Yes	Yes	8	4	2	1
R:R:F28	R:R:V307	3.93	1	Yes	No	8	5	2	2
R:R:L173	R:R:T119	4.42	0	No	No	5	5	2	1
R:R:L173	R:R:W207	9.11	0	No	Yes	5	6	2	2
R:R:F177	R:R:L196	13.4	0	No	No	5	5	2	1
R:R:L196	R:R:W198	7.97	0	No	Yes	5	7	1	2
R:R:W198	R:R:W207	5.62	0	Yes	Yes	7	6	2	2
R:R:D208	R:R:W207	4.47	1	Yes	Yes	5	6	1	2
R:R:F211	R:R:W207	12.03	0	No	Yes	5	6	1	2
R:R:D208	R:R:I284	4.2	1	Yes	No	5	5	1	1
R:R:D208	R:R:L288	8.14	1	Yes	No	5	4	1	2
R:R:F211	R:R:N215	8.46	0	No	No	5	6	1	2
R:R:I281	R:R:V212	4.61	0	No	No	7	6	1	2
R:R:F216	R:R:I281	16.33	0	No	No	8	7	2	1
R:R:I280	R:R:T310	4.56	0	No	No	6	8	1	2
R:R:F303	R:R:T283	5.19	1	Yes	Yes	4	5	1	2
R:R:F303	R:R:V307	3.93	1	Yes	No	4	5	1	2
R:R:A170	R:R:T119	3.36	0	No	No	7	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ID3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.57
Number of Linked Nodes	262
Number of Links	268
Number of Hubs	22
Number of Links mediated by Hubs	95
Number of Communities	3
Number of Nodes involved in Communities	12
Number of Links involved in Communities	13

Path Summary
Number Of Nodes in MetaPath	131
Number Of Links MetaPath	130
Number of Shortest Paths	40164
Length Of Smallest Path	3
Average Path Length	12.8879
Length of Longest Path	31
Minimum Path Strength	1.385
Average Path Strength	6.40021
Maximum Path Strength	20.31
Minimum Path Correlation	0.7
Average Path Correlation	0.944221
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	65.0408
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	30.5047
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein binding • binding • arrestin family protein binding • fatty acid binding • organic acid binding • ion binding • anion binding • lipid binding • carboxylic acid binding • monocarboxylic acid binding • small molecule binding • taste receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion • somatostatin secretion • negative regulation of cell communication • cell communication • negative regulation of peptide secretion • negative regulation of somatostatin secretion • peptide secretion • localization • secretion by cell • regulation of secretion by cell • negative regulation of secretion • amide transport • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of peptide hormone secretion • regulation of biological process • regulation of signaling • negative regulation of peptide hormone secretion • secretion • regulation of transport • regulation of hormone levels • regulation of peptide transport • cell-cell signaling • export from cell • establishment of localization • regulation of secretion • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • hexose transmembrane transport • carbohydrate transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • multicellular organismal process • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • ghrelin secretion • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • developmental process • regulation of osteoblast differentiation • cellular developmental process • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • cell differentiation • phospholipase C-activating G protein-coupled receptor signaling pathway • fat cell differentiation • positive regulation of brown fat cell differentiation • positive regulation of fat cell differentiation • regulation of brown fat cell differentiation • brown fat cell differentiation • regulation of fat cell differentiation • glucagon secretion • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • regulation of glucagon secretion • positive regulation of peptide secretion • positive regulation of glucagon secretion • positive regulation of peptide hormone secretion • positive regulation of transport • white fat cell differentiation • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular organelle • intracellular anatomical structure • intracellular membrane-bounded organelle • intracellular vesicle • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular organelle • intracellular anatomical structure • intracellular membrane-bounded organelle • intracellular vesicle • cytoplasmic vesicle • cytoplasm • vesicle • endocytic vesicle • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • endosome membrane • endosome • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • intracellular membraneless organelle • ciliary basal body • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • nucleolus • intracellular organelle lumen • organelle lumen • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • centriolar satellite • cytosol • nucleoplasm • Golgi apparatus • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7NR
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7NR
Name	9-Hydroxyoctadecanoic acid
Synonyms	9-Hydroxystearic acid
Identifier
Formula	C18 H36 O3
Molecular Weight	300.477
SMILES
PubChem	9601093
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	1
Total Bonds	56
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5NUL3
Sequence	>8ID3_nogp_Chain_R R T R F P F F S D V K G D H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R R R R G A T A C L V L N L F C A D L L F I S A I P L V L A V R W T E A W L L G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H L Q R G A R A V L L A L I W G Y S A V A A L P L C V F F R V V P Q R E I S I C T L I W P T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L A Y S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q D L V I W P S L F F W V V A F T F A N S A L N P I L Y N M T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IYS	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP	chim(NtGi1L-Gq)/β1/γ2	2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8IYS (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP		2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8T3O	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3O (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3Q	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3Q (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8G59	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(Gi1-CtGq)/β1/γ2	2.64	2023-03-08	doi.org/10.1126/science.add6220
	8G59 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		2.64	2023-03-08	doi.org/10.1126/science.add6220
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID6	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-	Gi1/β1/γ2	2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID6 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-		2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID8	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID8 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-		3	2023-03-15	doi.org/10.1126/science.add6220

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