psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F27	4.91	Yes	Yes	1	0	5
2	L:L:?1	R:R:F88	5.73	Yes	Yes	0	0	7
3	L:L:?1	R:R:M118	10.46	Yes	Yes	0	0	7
4	L:L:?1	R:R:T119	5.95	Yes	No	1	0	5
5	L:L:?1	R:R:L173	5.58	Yes	Yes	1	0	5
6	L:L:?1	R:R:W198	8.43	Yes	Yes	1	0	7
7	L:L:?1	R:R:E204	8.91	Yes	Yes	1	0	5
8	L:L:?1	R:R:D208	10.95	Yes	Yes	1	0	5
9	L:L:?1	R:R:F211	6.55	Yes	Yes	1	0	5
10	L:L:?1	R:R:W277	3.83	Yes	No	0	0	9
11	L:L:?1	R:R:I280	10.56	Yes	No	0	0	6
12	L:L:?1	R:R:I284	7.68	Yes	No	0	0	5
13	L:L:?1	R:R:I287	7.68	Yes	No	0	0	5
14	L:L:?1	R:R:F303	4.91	Yes	No	1	0	4
15	L:L:?1	R:R:V307	10.02	Yes	Yes	1	0	5
16	R:R:Q182	R:R:T23	11.34	Yes	No	0	2	8
17	R:R:I197	R:R:R24	8.77	No	No	0	4	5
18	R:R:F25	R:R:P26	4.33	No	No	0	5	5
19	R:R:F25	R:R:F27	5.36	No	Yes	0	5	5
20	R:R:F25	R:R:I287	6.28	No	No	0	5	5
21	R:R:P26	R:R:Q182	4.74	No	Yes	0	5	2
22	R:R:F115	R:R:F27	6.43	Yes	Yes	1	5	5
23	R:R:F177	R:R:F27	5.36	Yes	Yes	1	5	5
24	R:R:F27	R:R:F303	7.5	Yes	No	1	5	4
25	R:R:F28	R:R:V95	13.11	Yes	No	1	8	6
26	R:R:F115	R:R:F28	5.36	Yes	Yes	1	5	8
27	R:R:F28	R:R:M118	4.98	Yes	Yes	0	8	7
28	R:R:F28	R:R:F304	4.29	Yes	Yes	1	8	4
29	R:R:F28	R:R:V307	7.87	Yes	Yes	1	8	5
30	R:R:I193	R:R:S29	6.19	Yes	No	0	4	9
31	R:R:D30	R:R:K32	9.68	Yes	Yes	1	6	3
32	R:R:D30	R:R:R99	7.15	Yes	Yes	1	6	4
33	R:R:D30	R:R:P300	9.66	Yes	No	0	6	4
34	R:R:K32	R:R:L39	8.46	Yes	No	0	3	4
35	R:R:E43	R:R:K32	5.4	Yes	Yes	1	5	3
36	R:R:K32	R:R:R99	4.95	Yes	Yes	1	3	4
37	R:R:E102	R:R:K32	12.15	No	Yes	0	4	3
38	R:R:D34	R:R:H35	18.91	No	No	0	3	3
39	R:R:H35	R:R:V38	6.92	No	No	0	3	3
40	R:R:E102	R:R:R36	8.14	No	No	0	4	4
41	R:R:A40	R:R:W100	5.19	No	No	0	5	5
42	R:R:E43	R:R:R99	9.3	Yes	Yes	1	5	4
43	R:R:E43	R:R:F304	10.49	Yes	Yes	1	5	4
44	R:R:E43	R:R:W305	7.63	Yes	No	0	5	4
45	R:R:L96	R:R:T44	5.9	No	No	0	6	6
46	R:R:T44	R:R:W100	6.06	No	No	0	6	5
47	R:R:V46	R:R:W305	7.36	No	No	0	6	4
48	R:R:L47	R:R:L96	4.15	No	No	0	6	6
49	R:R:F304	R:R:L47	6.09	Yes	No	0	4	6
50	R:R:F51	R:R:I89	7.54	No	No	0	6	6
51	R:R:F51	R:R:I92	11.3	No	No	0	6	7
52	R:R:I89	R:R:S54	7.74	No	No	3	6	8
53	R:R:S314	R:R:S54	6.52	No	No	3	9	8
54	R:R:F82	R:R:N58	8.46	Yes	Yes	0	9	9
55	R:R:D85	R:R:N58	12.12	Yes	Yes	0	9	9
56	R:R:L86	R:R:N58	4.12	No	Yes	0	7	9
57	R:R:N58	R:R:P318	11.4	Yes	No	0	9	9
58	R:R:A61	R:R:F82	8.32	No	Yes	0	8	9
59	R:R:F82	R:R:L62	8.53	Yes	No	0	9	6
60	R:R:L64	R:R:R67	13.36	No	No	0	7	6
61	R:R:V65	R:R:V78	4.81	No	No	0	7	8
62	R:R:A75	R:R:R68	4.15	No	No	0	8	6
63	R:R:C76	R:R:R71	5.57	No	No	0	5	7
64	R:R:A73	R:R:E135	4.53	No	No	4	6	8
65	R:R:A73	R:R:R155	6.91	No	No	4	6	6
66	R:R:R136	R:R:T74	3.88	Yes	No	0	9	8
67	R:R:F82	R:R:V78	6.55	Yes	No	0	9	8
68	R:R:N80	R:R:V124	4.43	Yes	Yes	5	9	7
69	R:R:N80	R:R:T128	10.24	Yes	No	0	9	8
70	R:R:L159	R:R:N80	6.87	No	Yes	0	7	9
71	R:R:N80	R:R:W163	6.78	Yes	No	5	9	9
72	R:R:L81	R:R:T128	7.37	No	No	0	9	8
73	R:R:L129	R:R:L81	5.54	No	No	0	8	9
74	R:R:F82	R:R:N322	4.83	Yes	No	0	9	7
75	R:R:D85	R:R:T125	5.78	Yes	No	0	9	9
76	R:R:D85	R:R:S314	8.83	Yes	No	0	9	9
77	R:R:D85	R:R:N317	10.77	Yes	No	0	9	9
78	R:R:L87	R:R:S121	9.01	No	No	0	6	8
79	R:R:F88	R:R:S121	6.61	Yes	No	0	7	8
80	R:R:F88	R:R:T310	3.89	Yes	No	0	7	8
81	R:R:F311	R:R:F88	8.57	No	Yes	0	7	7
82	R:R:I89	R:R:S314	7.74	No	No	3	6	9
83	R:R:F311	R:R:I92	11.3	No	No	0	7	7
84	R:R:L106	R:R:L94	4.15	Yes	No	0	6	5
85	R:R:L114	R:R:L94	4.15	No	No	0	6	5
86	R:R:F304	R:R:V95	3.93	Yes	No	1	4	6
87	R:R:V98	R:R:W104	8.58	No	Yes	0	5	9
88	R:R:F304	R:R:R99	24.59	Yes	Yes	1	4	4
89	R:R:L106	R:R:W104	15.94	Yes	Yes	0	6	9
90	R:R:C111	R:R:W104	5.22	No	Yes	6	9	9
91	R:R:V179	R:R:W104	6.13	No	Yes	0	5	9
92	R:R:C194	R:R:W104	16.98	No	Yes	6	9	9
93	R:R:G107	R:R:P108	4.06	No	No	0	8	3
94	R:R:C111	R:R:C194	7.28	No	No	6	9	9
95	R:R:F115	R:R:L114	8.53	Yes	No	0	5	6
96	R:R:L114	R:R:M118	4.24	No	Yes	0	6	7
97	R:R:F115	R:R:F177	25.72	Yes	Yes	1	5	5
98	R:R:C174	R:R:Y116	5.38	No	No	0	4	5
99	R:R:L173	R:R:T119	4.42	Yes	No	1	5	5
100	R:R:L120	R:R:W163	4.56	No	No	0	5	9
101	R:R:L120	R:R:S166	4.5	No	No	0	5	8
102	R:R:F211	R:R:S123	3.96	Yes	No	1	5	6
103	R:R:N215	R:R:S123	4.47	Yes	No	1	6	6
104	R:R:I162	R:R:V124	4.61	No	Yes	0	7	7
105	R:R:V124	R:R:W163	13.48	Yes	No	5	7	9
106	R:R:S166	R:R:V124	4.85	No	Yes	0	8	7
107	R:R:F273	R:R:I126	5.02	Yes	No	0	9	8
108	R:R:I126	R:R:W277	17.62	No	No	0	8	9
109	R:R:L127	R:R:N215	4.12	No	Yes	0	6	6
110	R:R:F273	R:R:L129	4.87	Yes	No	0	9	8
111	R:R:L129	R:R:Y321	7.03	No	No	0	8	9
112	R:R:R136	R:R:V132	6.54	Yes	No	0	9	8
113	R:R:I223	R:R:S133	7.74	No	No	0	8	8
114	R:R:S133	R:R:S226	6.52	No	No	0	8	5
115	R:R:S133	R:R:Y227	5.09	No	Yes	0	8	9
116	R:R:E135	R:R:P150	7.86	No	No	0	8	6
117	R:R:E135	R:R:R155	4.65	No	No	4	8	6
118	R:R:R136	R:R:Y227	7.2	Yes	Yes	0	9	9
119	R:R:R136	R:R:Y321	6.17	Yes	No	0	9	9
120	R:R:M137	R:R:S226	7.67	Yes	No	0	8	5
121	R:R:I230	R:R:M137	4.37	No	Yes	0	8	8
122	R:R:H142	R:R:V138	4.15	Yes	No	0	5	4
123	R:R:I140	R:R:I230	4.42	No	No	0	8	8
124	R:R:H142	R:R:V147	5.54	Yes	Yes	2	5	5
125	R:R:H142	R:R:R148	4.51	Yes	No	2	5	4
126	R:R:G149	R:R:H142	7.94	No	Yes	2	4	5
127	R:R:R145	R:R:V147	6.54	No	Yes	0	5	5
128	R:R:R148	R:R:V147	5.23	No	Yes	2	4	5
129	R:R:G149	R:R:R148	4.5	No	No	2	4	4
130	R:R:G149	R:R:P150	4.06	No	No	0	4	6
131	R:R:A169	R:R:Y165	5.34	No	No	0	5	4
132	R:R:L214	R:R:Y165	7.03	No	No	0	4	4
133	R:R:N215	R:R:Y165	11.63	Yes	No	0	6	4
134	R:R:F176	R:R:P172	4.33	Yes	No	1	5	8
135	R:R:P172	R:R:W198	5.4	No	Yes	1	8	7
136	R:R:P172	R:R:W207	8.11	No	Yes	1	8	6
137	R:R:F177	R:R:L173	8.53	Yes	Yes	1	5	5
138	R:R:L173	R:R:W207	4.56	Yes	Yes	1	5	6
139	R:R:F176	R:R:V175	10.49	Yes	No	0	5	4
140	R:R:F176	R:R:W198	5.01	Yes	Yes	1	5	7
141	R:R:F176	R:R:P199	11.56	Yes	No	0	5	6
142	R:R:F177	R:R:L196	14.61	Yes	No	0	5	5
143	R:R:I197	R:R:R178	7.52	No	No	0	4	4
144	R:R:E190	R:R:P181	4.72	No	No	0	3	2
145	R:R:I193	R:R:Q182	10.98	Yes	Yes	0	4	2
146	R:R:I193	R:R:T195	6.08	Yes	No	0	4	4
147	R:R:L196	R:R:W198	12.53	No	Yes	0	5	7
148	R:R:E204	R:R:W198	25.08	Yes	Yes	1	5	7
149	R:R:W198	R:R:W207	6.56	Yes	Yes	1	7	6
150	R:R:P202	R:R:T200	6.99	No	No	0	3	3
151	R:R:I201	R:R:P202	8.47	No	No	0	4	3
152	R:R:D208	R:R:E204	5.2	Yes	Yes	1	5	5
153	R:R:E204	R:R:L288	3.98	Yes	No	1	5	4
154	R:R:E204	R:R:N291	6.57	Yes	No	0	5	2
155	R:R:I205	R:R:L288	4.28	No	No	0	4	4
156	R:R:D208	R:R:W207	5.58	Yes	Yes	1	5	6
157	R:R:F211	R:R:W207	17.04	Yes	Yes	1	5	6
158	R:R:D208	R:R:L288	10.86	Yes	No	1	5	4
159	R:R:F211	R:R:N215	12.08	Yes	Yes	1	5	6
160	R:R:I281	R:R:V212	6.14	No	No	0	7	6
161	R:R:L214	R:R:V218	4.47	No	No	0	4	5
162	R:R:F216	R:R:F273	4.29	No	Yes	0	8	9
163	R:R:F216	R:R:I281	12.56	No	No	0	8	7
164	R:R:F273	R:R:G220	4.52	Yes	No	0	9	6
165	R:R:I225	R:R:L221	7.14	No	No	0	4	2
166	R:R:F273	R:R:I223	7.54	Yes	No	0	9	8
167	R:R:M270	R:R:V224	4.56	No	No	0	8	5
168	R:R:L266	R:R:Y227	7.03	No	Yes	0	8	9
169	R:R:L269	R:R:Y227	8.21	No	Yes	0	8	9
170	R:R:I233	R:R:K229	8.72	No	No	0	5	5
171	R:R:K235	R:R:L231	9.87	No	No	0	5	6
172	R:R:F263	R:R:L231	4.87	No	No	0	7	6
173	R:R:L262	R:R:T234	4.42	No	No	0	8	8
174	R:R:D259	R:R:K235	6.91	No	No	0	7	5
175	R:R:R238	R:R:Y247	7.2	Yes	Yes	0	4	4
176	R:R:R238	R:R:V255	7.85	Yes	No	0	4	5
177	R:R:Q258	R:R:R238	4.67	No	Yes	0	6	4
178	R:R:D259	R:R:R238	4.76	No	Yes	0	7	4
179	R:R:L241	R:R:Y247	8.21	No	Yes	0	5	4
180	R:R:T242	R:R:Y247	4.99	No	Yes	0	4	4
181	R:R:Q252	R:R:T242	5.67	No	No	0	2	4
182	R:R:H251	R:R:S248	8.37	No	No	0	2	6
183	R:R:H251	R:R:R254	18.05	No	No	0	2	4
184	R:R:F260	R:R:R264	6.41	No	No	0	6	7
185	R:R:L262	R:R:L266	8.3	No	No	0	8	8
186	R:R:F267	R:R:V271	10.49	No	No	0	5	5
187	R:R:L269	R:R:L320	4.15	No	Yes	0	8	8
188	R:R:M276	R:R:S272	6.13	No	No	0	8	6
189	R:R:L320	R:R:S272	4.5	Yes	No	0	8	6
190	R:R:F273	R:R:F274	7.5	Yes	No	0	9	6
191	R:R:M276	R:R:N313	9.82	No	No	0	8	9
192	R:R:L316	R:R:M276	8.48	No	No	0	6	8
193	R:R:N313	R:R:W277	22.6	No	No	0	9	9
194	R:R:F309	R:R:P279	7.22	No	No	0	7	9
195	R:R:I280	R:R:T283	4.56	No	No	0	6	5
196	R:R:I280	R:R:T310	7.6	No	No	0	6	8
197	R:R:T283	R:R:V306	9.52	No	No	0	5	6
198	R:R:I298	R:R:L286	7.14	No	No	0	3	5
199	R:R:I289	R:R:L296	4.28	No	No	0	4	5
200	R:R:Q290	R:R:Q294	5.12	No	No	0	4	1
201	R:R:I298	R:R:Q290	6.86	No	No	0	3	4
202	R:R:D295	R:R:K293	13.83	No	No	0	3	1
203	R:R:K293	R:R:L296	4.23	No	No	0	1	5
204	R:R:I298	R:R:L296	7.14	No	No	0	3	5
205	R:R:S301	R:R:W305	4.94	No	No	0	2	4
206	R:R:F303	R:R:V307	7.87	No	Yes	1	4	5
207	R:R:F311	R:R:V307	3.93	No	Yes	0	7	5
208	R:R:F292	R:R:I201	3.77	No	No	0	1	4
209	R:R:A130	R:R:P219	3.74	No	No	0	7	9
210	R:R:G122	R:R:T125	3.64	No	No	0	7	9
211	R:R:P279	R:R:S278	3.56	No	No	0	9	7
212	R:R:P181	R:R:V180	3.53	No	No	0	2	4
213	R:R:P219	R:R:V218	3.53	No	No	0	9	5
214	R:R:P279	R:R:V306	3.53	No	No	0	9	6
215	R:R:Q182	R:R:R24	3.5	Yes	No	0	2	5
216	R:R:A315	R:R:S54	3.42	No	No	0	6	8
217	R:R:A315	R:R:V53	3.39	No	No	0	6	5
218	R:R:A84	R:R:V124	3.39	No	Yes	0	8	7
219	R:R:I92	R:R:P93	3.39	No	No	0	7	9
220	R:R:A130	R:R:V222	3.39	No	No	0	7	6
221	R:R:A170	R:R:T119	3.36	No	No	0	7	5
222	R:R:S248	R:R:S250	3.26	No	No	0	6	5
223	R:R:S192	R:R:V179	3.23	No	No	0	3	5
224	R:R:A91	R:R:M118	3.22	No	Yes	0	6	7
225	R:R:T195	R:R:V180	3.17	No	No	0	4	4
226	R:R:A308	R:R:L47	3.15	No	No	0	4	6
227	R:R:A110	R:R:L106	3.15	No	Yes	0	5	6
228	R:R:A131	R:R:L158	3.15	No	No	0	7	5
229	R:R:I282	R:R:S278	3.1	No	No	0	5	7
230	R:R:M137	R:R:V138	3.04	Yes	No	0	8	4
231	R:R:M137	R:R:V141	3.04	Yes	No	0	8	6
232	R:R:A246	R:R:Q252	3.03	No	No	0	4	2
233	R:R:M323	R:R:T265	3.01	No	No	0	5	8
234	R:R:L64	R:R:V63	2.98	No	No	0	7	4
235	R:R:L79	R:R:V65	2.98	No	No	0	5	7
236	R:R:L77	R:R:V132	2.98	No	No	0	7	8
237	R:R:L87	R:R:V117	2.98	No	No	0	6	4
238	R:R:L113	R:R:V109	2.98	No	No	0	5	2
239	R:R:L134	R:R:V222	2.98	No	No	0	5	6
240	R:R:L285	R:R:V212	2.98	No	No	0	6	6
241	R:R:L49	R:R:T45	2.95	No	No	0	4	4
242	R:R:L217	R:R:T213	2.95	No	No	0	4	5
243	R:R:I191	R:R:I193	2.94	No	Yes	0	4	4
244	R:R:K229	R:R:M137	2.88	No	Yes	0	5	8
245	R:R:I282	R:R:L286	2.85	No	No	0	5	5
246	R:R:L320	R:R:M323	2.83	Yes	No	0	8	5
247	R:R:G107	R:R:W104	2.81	No	Yes	0	8	9
248	R:R:A75	R:R:R71	2.77	No	No	0	8	7
249	R:R:L158	R:R:L77	2.77	No	No	0	5	7
250	R:R:L231	R:R:L262	2.77	No	No	0	6	8
251	R:R:L268	R:R:L320	2.77	No	Yes	0	6	8
252	R:R:K229	R:R:Q232	2.71	No	No	0	5	4
253	R:R:A170	R:R:Y116	2.67	No	No	0	7	5
254	R:R:F274	R:R:V224	2.62	No	No	0	6	5
255	R:R:A41	R:R:W100	2.59	No	No	0	3	5
256	R:R:F51	R:R:L55	2.44	No	No	0	6	5
257	R:R:F216	R:R:L217	2.44	No	No	0	8	4
258	R:R:L79	R:R:R71	2.43	No	No	0	5	7
259	R:R:L171	R:R:Y116	2.34	No	No	0	5	5
260	R:R:F260	R:R:R261	2.14	No	No	0	6	8
261	R:R:G57	R:R:P318	2.03	No	No	0	9	9
262	R:R:C60	R:R:G57	1.96	No	No	0	6	9
263	R:R:A154	R:R:P150	1.87	No	No	0	5	6
264	R:R:G203	R:R:S206	1.86	No	No	0	3	4
265	R:R:G146	R:R:V147	1.84	No	Yes	0	6	5
266	R:R:G203	R:R:T200	1.82	No	No	0	3	3
267	R:R:A73	R:R:C139	1.81	No	No	0	6	8
268	R:R:G57	R:R:L56	1.71	No	No	0	9	4
269	R:R:D34	R:R:G33	1.68	No	No	0	3	3
270	R:R:A312	R:R:I50	1.62	No	No	0	5	7
271	R:R:S90	R:R:V117	1.62	No	No	0	4	4
272	R:R:V42	R:R:V46	1.6	No	No	0	5	6
273	R:R:T44	R:R:V48	1.59	No	No	0	6	4
274	R:R:C83	R:R:L62	1.59	No	No	0	5	6
275	R:R:A97	R:R:L106	1.58	No	Yes	0	4	6
276	R:R:A167	R:R:L120	1.58	No	No	0	3	5
277	R:R:A312	R:R:L316	1.58	No	No	0	5	6
278	R:R:I205	R:R:V209	1.54	No	No	0	4	4
279	R:R:H112	R:R:P108	1.53	No	No	0	7	3
280	R:R:M270	R:R:S228	1.53	No	No	0	8	3
281	R:R:K239	R:R:V243	1.52	No	No	0	5	2
282	R:R:M323	R:R:T324	1.51	No	No	0	5	7
283	R:R:G72	R:R:R155	1.5	No	No	0	7	6
284	R:R:L241	R:R:S237	1.5	No	No	0	5	6
285	R:R:L245	R:R:S244	1.5	No	No	0	3	5
286	R:R:I201	R:R:I205	1.47	No	No	0	4	4
287	R:R:L302	R:R:T283	1.47	No	No	0	5	5
288	R:R:D30	R:R:V31	1.46	Yes	No	0	6	6
289	R:R:Q257	R:R:S256	1.44	No	No	0	5	4
290	R:R:I319	R:R:L320	1.43	No	Yes	0	7	8
291	R:R:I140	R:R:Q144	1.37	No	No	0	8	6
292	R:R:P300	R:R:W299	1.35	No	No	0	4	4
293	R:R:R153	R:R:V157	1.31	No	No	0	5	4
294	R:R:H35	R:R:L39	1.29	No	No	0	3	4
295	R:R:H251	R:R:Y247	1.09	No	Yes	0	2	4
296	R:R:R67	R:R:R68	1.07	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.47667	15	1	0
2	R:R:F27	5.912	5	1	5
3	R:R:F28	7.122	5	1	8
4	R:R:D30	6.9875	4	1	6
5	R:R:K32	8.128	5	1	3
6	R:R:E43	8.205	4	1	5
7	R:R:N58	9.025	4	0	9
8	R:R:N80	7.08	4	5	9
9	R:R:F82	7.338	5	0	9
10	R:R:D85	9.375	4	0	9
11	R:R:F88	6.2	4	0	7
12	R:R:R99	11.4975	4	1	4
13	R:R:W104	9.27667	6	6	9
14	R:R:L106	6.205	4	0	6
15	R:R:F115	11.51	4	1	5
16	R:R:M118	5.725	4	0	7
17	R:R:V124	6.152	5	5	7
18	R:R:R136	5.9475	4	0	9
19	R:R:M137	4.2	5	0	8
20	R:R:H142	5.535	4	2	5
21	R:R:V147	4.7875	4	2	5
22	R:R:L173	5.7725	4	1	5
23	R:R:F176	7.8475	4	1	5
24	R:R:F177	13.555	4	1	5
25	R:R:Q182	7.64	4	0	2
26	R:R:I193	6.5475	4	0	4
27	R:R:W198	10.5017	6	1	7
28	R:R:E204	9.948	5	1	5
29	R:R:W207	8.37	5	1	6
30	R:R:D208	8.1475	4	1	5
31	R:R:F211	9.9075	4	1	5
32	R:R:N215	8.075	4	1	6
33	R:R:Y227	6.8825	4	0	9
34	R:R:R238	6.12	4	0	4
35	R:R:Y247	5.3725	4	0	4
36	R:R:F273	5.62333	6	0	9
37	R:R:F304	9.878	5	1	4
38	R:R:V307	7.4225	4	1	5
39	R:R:L320	3.136	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F27	15.906	4.91	Yes	Yes	1	0	5
2	R:R:F25	R:R:F27	18.8889	5.36	No	Yes	0	5	5
3	R:R:F25	R:R:P26	30.215	4.33	No	No	0	5	5
4	R:R:P26	R:R:Q182	27.9392	4.74	No	Yes	0	5	2
5	L:L:?1	R:R:I287	14.7072	7.68	Yes	No	0	0	5
6	R:R:F25	R:R:I287	13.5368	6.28	No	No	0	5	5
7	L:L:?1	R:R:M118	40.3259	10.46	Yes	Yes	0	0	7
8	R:R:F28	R:R:M118	29.3738	4.98	Yes	Yes	0	8	7
9	R:R:F28	R:R:F304	60.2715	4.29	Yes	Yes	1	8	4
10	L:L:?1	R:R:V307	54.9478	10.02	Yes	Yes	1	0	5
11	R:R:F28	R:R:V307	35.8597	7.87	Yes	Yes	1	8	5
12	R:R:I193	R:R:Q182	16.4384	10.98	Yes	Yes	0	4	2
13	R:R:F304	R:R:R99	23.0178	24.59	Yes	Yes	1	4	4
14	R:R:E43	R:R:F304	22.8797	10.49	Yes	Yes	1	5	4
15	R:R:E43	R:R:K32	14.2642	5.4	Yes	Yes	1	5	3
16	R:R:K32	R:R:R99	14.2033	4.95	Yes	Yes	1	3	4
17	R:R:K32	R:R:L39	17.9786	8.46	Yes	No	0	3	4
18	R:R:H35	R:R:L39	14.3983	1.29	No	No	0	3	4
19	R:R:F304	R:R:L47	14.6666	6.09	Yes	No	0	4	6
20	R:R:L47	R:R:L96	11.1147	4.15	No	No	0	6	6
21	L:L:?1	R:R:F88	36.2214	5.73	Yes	Yes	0	0	7
22	R:R:F311	R:R:F88	33.4945	8.57	No	Yes	0	7	7
23	R:R:F311	R:R:I92	72.2924	11.3	No	No	0	7	7
24	R:R:F51	R:R:I92	68.3992	11.3	No	No	0	6	7
25	R:R:F311	R:R:V307	42.6342	3.93	No	Yes	0	7	5
26	R:R:F51	R:R:I89	64.3679	7.54	No	No	0	6	6
27	R:R:I89	R:R:S314	55.8906	7.74	No	No	3	6	9
28	R:R:D85	R:R:S314	54.1472	8.83	Yes	No	0	9	9
29	R:R:D85	R:R:N58	45.8244	12.12	Yes	Yes	0	9	9
30	R:R:F82	R:R:N58	33.0963	8.46	Yes	Yes	0	9	9
31	R:R:F82	R:R:V78	22.266	6.55	Yes	No	0	9	8
32	R:R:V65	R:R:V78	20.0756	4.81	No	No	0	7	8
33	R:R:L79	R:R:V65	17.877	2.98	No	No	0	5	7
34	R:R:L79	R:R:R71	15.6703	2.43	No	No	0	5	7
35	R:R:A75	R:R:R71	11.2326	2.77	No	No	0	8	7
36	L:L:?1	R:R:W277	100	3.83	Yes	No	0	0	9
37	R:R:I126	R:R:W277	85.8943	17.62	No	No	0	8	9
38	R:R:F273	R:R:I126	85.0652	5.02	Yes	No	0	9	8
39	R:R:F273	R:R:I223	54.1025	7.54	Yes	No	0	9	8
40	R:R:I223	R:R:S133	53.119	7.74	No	No	0	8	8
41	R:R:S133	R:R:S226	31.2757	6.52	No	No	0	8	5
42	R:R:M137	R:R:S226	29.9915	7.67	Yes	No	0	8	5
43	R:R:M137	R:R:V138	19.4254	3.04	Yes	No	0	8	4
44	R:R:H142	R:R:V138	18.068	4.15	Yes	No	0	5	4
45	R:R:G149	R:R:H142	11.2244	7.94	No	Yes	2	4	5
46	R:R:G149	R:R:P150	10.0419	4.06	No	No	0	4	6
47	R:R:F273	R:R:L129	23.408	4.87	Yes	No	0	9	8
48	R:R:L129	R:R:L81	15.6866	5.54	No	No	0	8	9
49	R:R:L81	R:R:T128	14.3008	7.37	No	No	0	9	8
50	R:R:N80	R:R:T128	12.9069	10.24	Yes	No	0	9	8
51	L:L:?1	R:R:I280	23.2942	10.56	Yes	No	0	0	6
52	R:R:L114	R:R:M118	17.7267	4.24	No	Yes	0	6	7
53	R:R:L114	R:R:L94	21.5508	4.15	No	No	0	6	5
54	R:R:L106	R:R:L94	19.9415	4.15	Yes	No	0	6	5
55	R:R:L106	R:R:W104	15.0648	15.94	Yes	Yes	0	6	9
56	L:L:?1	R:R:F211	18.0274	6.55	Yes	Yes	1	0	5
57	R:R:F211	R:R:N215	14.9104	12.08	Yes	Yes	1	5	6
58	R:R:S133	R:R:Y227	28.3171	5.09	No	Yes	0	8	9
59	R:R:N215	R:R:Y165	12.025	11.63	Yes	No	0	6	4
60	L:L:?1	R:R:D208	14.5772	10.95	Yes	Yes	1	0	5
61	L:L:?1	R:R:E204	14.6422	8.91	Yes	Yes	1	0	5
62	R:R:E204	R:R:L288	12.3948	3.98	Yes	No	1	5	4
63	R:R:I205	R:R:L288	22.331	4.28	No	No	0	4	4
64	R:R:I201	R:R:I205	16.796	1.47	No	No	0	4	4
65	R:R:I201	R:R:P202	11.2285	8.47	No	No	0	4	3
66	R:R:D208	R:R:L288	12.6874	10.86	Yes	No	1	5	4
67	R:R:L266	R:R:Y227	27.4922	7.03	No	Yes	0	8	9
68	R:R:N313	R:R:W277	15.0567	22.6	No	No	0	9	9
69	R:R:M276	R:R:N313	13.8863	9.82	No	No	0	8	9
70	R:R:M276	R:R:S272	10.0175	6.13	No	No	0	8	6
71	R:R:L262	R:R:L266	26.1836	8.3	No	No	0	8	8
72	R:R:L231	R:R:L262	23.6356	2.77	No	No	0	6	8
73	R:R:K235	R:R:L231	20.9493	9.87	No	No	0	5	6
74	R:R:D259	R:R:K235	19.7139	6.91	No	No	0	7	5
75	R:R:D259	R:R:R238	18.3566	4.76	No	Yes	0	7	4
76	R:R:R238	R:R:Y247	14.2399	7.2	Yes	Yes	0	4	4
77	R:R:I280	R:R:T283	23.3714	4.56	No	No	0	6	5
78	R:R:T283	R:R:V306	20.4413	9.52	No	No	0	5	6
79	R:R:P279	R:R:V306	18.9174	3.53	No	No	0	9	6
80	R:R:P279	R:R:S278	15.8451	3.56	No	No	0	9	7
81	R:R:I282	R:R:S278	14.2967	3.1	No	No	0	5	7
82	R:R:I282	R:R:L286	12.7403	2.85	No	No	0	5	5
83	R:R:I298	R:R:L286	11.1757	7.14	No	No	0	3	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F27	4.91	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F88	5.73	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M118	10.46	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T119	5.95	1	Yes	No	0	5	0	1
L:L:?1	R:R:L173	5.58	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W198	8.43	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:E204	8.91	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:D208	10.95	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F211	6.55	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W277	3.83	1	Yes	No	0	9	0	1
L:L:?1	R:R:I280	10.56	1	Yes	No	0	6	0	1
L:L:?1	R:R:I284	7.68	1	Yes	No	0	5	0	1
L:L:?1	R:R:I287	7.68	1	Yes	No	0	5	0	1
L:L:?1	R:R:F303	4.91	1	Yes	No	0	4	0	1
L:L:?1	R:R:V307	10.02	1	Yes	Yes	0	5	0	1
R:R:F25	R:R:F27	5.36	0	No	Yes	5	5	2	1
R:R:F25	R:R:I287	6.28	0	No	No	5	5	2	1
R:R:F115	R:R:F27	6.43	1	Yes	Yes	5	5	2	1
R:R:F177	R:R:F27	5.36	1	Yes	Yes	5	5	2	1
R:R:F27	R:R:F303	7.5	1	Yes	No	5	4	1	1
R:R:F115	R:R:F28	5.36	1	Yes	Yes	5	8	2	2
R:R:F28	R:R:M118	4.98	1	Yes	Yes	8	7	2	1
R:R:F28	R:R:V307	7.87	1	Yes	Yes	8	5	2	1
R:R:F88	R:R:S121	6.61	0	Yes	No	7	8	1	2
R:R:F88	R:R:T310	3.89	0	Yes	No	7	8	1	2
R:R:F311	R:R:F88	8.57	0	No	Yes	7	7	2	1
R:R:F115	R:R:L114	8.53	1	Yes	No	5	6	2	2
R:R:L114	R:R:M118	4.24	0	No	Yes	6	7	2	1
R:R:F115	R:R:F177	25.72	1	Yes	Yes	5	5	2	2
R:R:L173	R:R:T119	4.42	1	Yes	No	5	5	1	1
R:R:F211	R:R:S123	3.96	1	Yes	No	5	6	1	2
R:R:N215	R:R:S123	4.47	1	Yes	No	6	6	2	2
R:R:I126	R:R:W277	17.62	0	No	No	8	9	2	1
R:R:F176	R:R:P172	4.33	1	Yes	No	5	8	2	2
R:R:P172	R:R:W198	5.4	1	No	Yes	8	7	2	1
R:R:P172	R:R:W207	8.11	1	No	Yes	8	6	2	2
R:R:F177	R:R:L173	8.53	1	Yes	Yes	5	5	2	1
R:R:L173	R:R:W207	4.56	1	Yes	Yes	5	6	1	2
R:R:F176	R:R:W198	5.01	1	Yes	Yes	5	7	2	1
R:R:F177	R:R:L196	14.61	1	Yes	No	5	5	2	2
R:R:L196	R:R:W198	12.53	0	No	Yes	5	7	2	1
R:R:E204	R:R:W198	25.08	1	Yes	Yes	5	7	1	1
R:R:W198	R:R:W207	6.56	1	Yes	Yes	7	6	1	2
R:R:D208	R:R:E204	5.2	1	Yes	Yes	5	5	1	1
R:R:E204	R:R:L288	3.98	1	Yes	No	5	4	1	2
R:R:E204	R:R:N291	6.57	1	Yes	No	5	2	1	2
R:R:D208	R:R:W207	5.58	1	Yes	Yes	5	6	1	2
R:R:F211	R:R:W207	17.04	1	Yes	Yes	5	6	1	2
R:R:D208	R:R:L288	10.86	1	Yes	No	5	4	1	2
R:R:F211	R:R:N215	12.08	1	Yes	Yes	5	6	1	2
R:R:N313	R:R:W277	22.6	0	No	No	9	9	2	1
R:R:I280	R:R:T283	4.56	0	No	No	6	5	1	2
R:R:I280	R:R:T310	7.6	0	No	No	6	8	1	2
R:R:F303	R:R:V307	7.87	1	No	Yes	4	5	1	1
R:R:F311	R:R:V307	3.93	0	No	Yes	7	5	2	1
R:R:A170	R:R:T119	3.36	0	No	No	7	5	2	1
R:R:A91	R:R:M118	3.22	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IYS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.83
Number of Linked Nodes	272
Number of Links	296
Number of Hubs	39
Number of Links mediated by Hubs	143
Number of Communities	6
Number of Nodes involved in Communities	41
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	56176
Length Of Smallest Path	3
Average Path Length	13.5004
Length of Longest Path	35
Minimum Path Strength	1.505
Average Path Strength	7.23229
Maximum Path Strength	20.165
Minimum Path Correlation	0.7
Average Path Correlation	0.939153
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	59.0241
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.4799
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• pyrophosphatase activity • enzyme regulator activity • GTPase activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • hydrolase activity • GTPase regulator activity • enzyme activator activity • ribonucleoside triphosphate phosphatase activity • GTPase activator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • molecular function regulator activity • hydrolase activity, acting on acid anhydrides • catalytic activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of protein modification process • regulation of catalytic activity • regulation of protein phosphorylation • negative regulation of biological process • negative regulation of phosphate metabolic process • negative regulation of catalytic activity • regulation of transferase activity • regulation of primary metabolic process • negative regulation of kinase activity • negative regulation of transferase activity • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • negative regulation of cellular process • protein metabolic process • phosphorus metabolic process • protein modification process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • negative regulation of molecular function • primary metabolic process • negative regulation of protein kinase activity • regulation of protein kinase activity • regulation of macromolecule metabolic process • regulation of molecular function • regulation of kinase activity • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • metabolic process • macromolecule metabolic process • negative regulation of phosphorylation • regulation of metabolic process • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • cytosolic region • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • photoreceptor disc membrane • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • arrestin family protein binding • fatty acid binding • organic acid binding • ion binding • anion binding • lipid binding • carboxylic acid binding • monocarboxylic acid binding • small molecule binding • taste receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of peptide secretion • transport • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion • somatostatin secretion • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of somatostatin secretion • peptide secretion • localization • secretion by cell • regulation of secretion by cell • negative regulation of secretion • amide transport • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of peptide hormone secretion • regulation of signaling • negative regulation of peptide hormone secretion • secretion • regulation of transport • regulation of hormone levels • regulation of peptide transport • export from cell • establishment of localization • regulation of secretion • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • hexose transmembrane transport • carbohydrate transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • ghrelin secretion • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of osteoblast differentiation • cellular developmental process • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • cell differentiation • fat cell differentiation • positive regulation of brown fat cell differentiation • positive regulation of fat cell differentiation • regulation of brown fat cell differentiation • brown fat cell differentiation • regulation of fat cell differentiation • glucagon secretion • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • regulation of glucagon secretion • positive regulation of peptide secretion • positive regulation of glucagon secretion • positive regulation of peptide hormone secretion • positive regulation of transport • white fat cell differentiation • intracellular vesicle • cytoplasmic vesicle • endocytic vesicle • ciliary membrane • plasma membrane region • cell projection membrane • endosome membrane • endosome • cytoplasmic vesicle membrane • vesicle membrane • intracellular membraneless organelle • ciliary basal body • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YN9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YN9
Name	3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid
Synonyms
Identifier
Formula	C23 H21 F O3
Molecular Weight	364.409
SMILES
PubChem	57522038
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	0
Total Bonds	50
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5NUL3
Sequence	>8IYS_nogp_Chain_R T R F P F F S D V K G D H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R R R R G A T A C L V L N L F C A D L L F I S A I P L V L A V R W T E A W L L G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H L Q R G V R G P G R R A R A V L L A L I W G Y S A V A A L P L C V F F R V V P Q Q E I S I C T L I W P T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L A Y S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q D L V I W P S L F F W V V A F T F A N S A L N P I L Y N M T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8T3Q	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.14	2024-01-24	10.1126/sciadv.adj2384
	8T3Q (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.14	2024-01-24	10.1126/sciadv.adj2384
	8T3O	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	2Y5	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.06	2024-01-17	10.1126/sciadv.adj2384
	8T3O (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	2Y5		3.06	2024-01-17	10.1126/sciadv.adj2384
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	10.1038/s41422-023-00835-x
	8IYS	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP	chim(NtGi1L-Gq)/β1/γ2	2.95	2023-06-21	10.1038/s41422-023-00835-x
	8IYS (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP		2.95	2023-06-21	10.1038/s41422-023-00835-x
	8ID9	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-	Gi1/β1/γ2	3	2023-03-15	10.1126/science.add6220
	8ID9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Eicosapentaenoic acid	-		3	2023-03-15	10.1126/science.add6220
	8ID8	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	Gi1/β1/γ2	3	2023-03-15	10.1126/science.add6220
	8ID8 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3	2023-03-15	10.1126/science.add6220
	8ID6	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-	Gi1/β1/γ2	2.8	2023-03-15	10.1126/science.add6220
	8ID6 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-		2.8	2023-03-15	10.1126/science.add6220
	8ID4	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-	Gi1/β1/γ2	3.1	2023-03-15	10.1126/science.add6220
	8ID4 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-		3.1	2023-03-15	10.1126/science.add6220
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	10.1126/science.add6220
	8G59	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(Gi1-CtGq)/β1/γ2	2.64	2023-03-08	10.1126/science.add6220
	8G59 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		2.64	2023-03-08	10.1126/science.add6220

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Download 8IYS_nogp.zip

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