Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.993081310
2R:R:F25 6.08415
3R:R:P26 4.386515
4R:R:F27 5.32415
5R:R:F28 4.574518
6R:R:D30 5.3725416
7R:R:N58 7.5675439
8R:R:L62 4.0225406
9R:R:F82 5.188539
10R:R:D85 7.506509
11R:R:F88 6.3775407
12R:R:I92 6.41507
13R:R:R99 10.225414
14R:R:W104 10.0925409
15R:R:F115 7.885405
16R:R:M137 4.488508
17R:R:Y165 4.21404
18R:R:I193 7.855414
19R:R:E204 10.9075415
20R:R:D208 9.8875415
21R:R:Y227 5.36509
22R:R:R238 7.9775444
23R:R:Y247 6.178544
24R:R:L266 4.8675408
25R:R:F273 5.43667629
26R:R:M276 3.68408
27R:R:W277 8.85429
28R:R:L288 6.415404
29R:R:F303 6.29833614
30R:R:F304 9.735414
31R:R:F311 5.708507
32R:R:N313 6.27409
33R:R:Y321 6.305409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:F27 23.87475.69YesYes105
2R:R:F25 R:R:F27 18.46515.36YesYes155
3R:R:F25 R:R:P26 26.81864.33YesYes155
4R:R:I193 R:R:P26 20.20775.08YesYes145
5R:R:I193 R:R:Q182 12.22289.61YesNo042
6L:L:?1 R:R:F303 36.5689.11YesYes104
7R:R:F25 R:R:F303 19.96776.43YesYes154
8R:R:F25 R:R:Q290 10.87718.2YesNo054
9R:R:F28 R:R:F303 18.31146.43YesYes184
10R:R:F28 R:R:F304 16.63164.29YesYes184
11R:R:F304 R:R:R99 11.64418.17YesYes144
12L:L:?1 R:R:F88 44.41644.55YesYes007
13R:R:F311 R:R:F88 17.083311.79YesYes077
14R:R:F88 R:R:T310 58.59973.89YesNo078
15R:R:T310 R:R:W277 1003.64NoYes089
16R:R:N313 R:R:W277 65.32366.78YesYes099
17R:R:N313 R:R:S314 35.98615.96YesNo099
18R:R:S314 R:R:S54 12.19454.89NoNo098
19R:R:N58 R:R:S54 10.8524.47YesNo098
20L:L:?1 R:R:I280 41.79086.67YesNo006
21R:R:I280 R:R:T310 41.801810.64NoNo068
22R:R:D85 R:R:S314 23.86218.83YesNo099
23R:R:D85 R:R:N58 24.12256.73YesYes099
24R:R:N313 R:R:N317 24.10689.54YesNo099
25R:R:D85 R:R:N317 23.582912.12YesNo099
26R:R:F82 R:R:N58 30.10766.04YesYes399
27R:R:A61 R:R:F82 15.06635.55NoYes089
28R:R:F82 R:R:L62 10.88336.09YesYes096
29R:R:A61 R:R:N322 12.90191.56NoNo087
30R:R:D85 R:R:L81 27.12444.07YesNo099
31R:R:L81 R:R:T128 19.1854.42NoNo098
32R:R:N80 R:R:T128 13.33797.31NoNo098
33R:R:F273 R:R:W277 37.88545.01YesYes299
34R:R:F273 R:R:I223 32.98576.28YesNo098
35R:R:I223 R:R:S133 32.33796.19NoNo088
36R:R:S133 R:R:Y227 26.10973.82NoYes089
37R:R:L129 R:R:L81 10.78775.54NoNo089
38R:R:F177 R:R:L196 10.252810.96NoNo055
39L:L:?1 R:R:F211 10.02384.55YesNo005
40L:L:?1 R:R:D208 11.173513.96YesYes105
41R:R:L266 R:R:Y227 15.83178.21YesYes089
42R:R:L262 R:R:L266 13.21562.77NoYes088
43R:R:L262 R:R:T234 12.34514.42NoNo088
44R:R:R238 R:R:T234 11.52953.88YesNo048
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F27 5.69 1 Yes Yes 0 5 0 1
L:L:?1 R:R:F88 4.55 1 Yes Yes 0 7 0 1
L:L:?1 R:R:M118 13.22 1 Yes No 0 7 0 1
L:L:?1 R:R:T119 6.89 1 Yes No 0 5 0 1
L:L:?1 R:R:G122 4.8 1 Yes No 0 7 0 1
L:L:?1 R:R:W198 4.26 1 Yes No 0 7 0 1
L:L:?1 R:R:E204 6.19 1 Yes Yes 0 5 0 1
L:L:?1 R:R:D208 13.96 1 Yes Yes 0 5 0 1
L:L:?1 R:R:F211 4.55 1 Yes No 0 5 0 1
L:L:?1 R:R:I280 6.67 1 Yes No 0 6 0 1
L:L:?1 R:R:I284 9.34 1 Yes No 0 5 0 1
L:L:?1 R:R:I287 14.68 1 Yes No 0 5 0 1
L:L:?1 R:R:F303 9.11 1 Yes Yes 0 4 0 1
R:R:F25 R:R:F27 5.36 1 Yes Yes 5 5 2 1
R:R:F25 R:R:F303 6.43 1 Yes Yes 5 4 2 1
R:R:F27 R:R:L196 4.87 1 Yes No 5 5 1 2
R:R:F27 R:R:F303 5.36 1 Yes Yes 5 4 1 1
R:R:F28 R:R:F303 6.43 1 Yes Yes 8 4 2 1
R:R:F28 R:R:V307 3.93 1 Yes No 8 5 2 2
R:R:F88 R:R:S121 5.28 0 Yes No 7 8 1 2
R:R:F88 R:R:T310 3.89 0 Yes No 7 8 1 2
R:R:F311 R:R:F88 11.79 0 Yes Yes 7 7 2 1
R:R:L173 R:R:T119 7.37 0 No No 5 5 2 1
R:R:L196 R:R:W198 11.39 0 No No 5 7 2 1
R:R:E204 R:R:W198 22.9 1 Yes No 5 7 1 1
R:R:E204 R:R:L288 9.28 1 Yes Yes 5 4 1 2
R:R:E204 R:R:N291 5.26 1 Yes No 5 2 1 2
R:R:D208 R:R:W207 7.82 1 Yes No 5 6 1 2
R:R:F211 R:R:W207 18.04 0 No No 5 6 1 2
R:R:D208 R:R:I284 4.2 1 Yes No 5 5 1 1
R:R:D208 R:R:L288 13.57 1 Yes Yes 5 4 1 2
R:R:F211 R:R:N215 14.5 0 No No 5 6 1 2
R:R:I280 R:R:T310 10.64 0 No No 6 8 1 2
R:R:I284 R:R:I287 4.42 1 No No 5 5 1 1
R:R:F303 R:R:V307 7.87 1 Yes No 4 5 1 2
R:R:F311 R:R:V307 3.93 0 Yes No 7 5 2 2
R:R:A170 R:R:T119 3.36 0 No No 7 5 2 1
R:R:F303 R:R:T283 2.59 1 Yes No 4 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8ID6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.64
Number of Linked Nodes 251
Number of Links 270
Number of Hubs 33
Number of Links mediated by Hubs 126
Number of Communities 4
Number of Nodes involved in Communities 30
Number of Links involved in Communities 39
Path Summary
Number Of Nodes in MetaPath 45
Number Of Links MetaPath 44
Number of Shortest Paths 87011
Length Of Smallest Path 3
Average Path Length 13.4725
Length of Longest Path 25
Minimum Path Strength 1.245
Average Path Strength 6.14461
Maximum Path Strength 17.145
Minimum Path Correlation 0.7
Average Path Correlation 0.943307
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 6.25
Average % Of Corr. Nodes 61.7448
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.1426
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeOLA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeOLA
NameOLEIC ACID
Synonyms
Identifier
FormulaC18 H34 O2
Molecular Weight282.461
SMILES
PubChem445639
Formal Charge0
Total Atoms54
Total Chiral Atoms0
Total Bonds53
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ5NUL3
Sequence
>8ID6_nogp_Chain_R
TRFPFFSDV KHRLVLAAV ETTVLVLIF AVSLLGNVC ALVLVARRR 
ACLVLNLFC ADLLFISAI PLVLAVRWT EAWLLGPVA CHLLFYVMT 
LSGSVTILT LAAVSLERM VCIVHLQGR RARAVLLAL IWGYSAVAA 
LPLCVFFRV VPQRLPGAD QEISICTLI WPTIPGEIS WDVSFVTLN 
FLVPGLVIV ISYSKILQI TKASRKRLT VSLAYSESH QIRVSQQDF 
RLFRTLFLL MVSFFIMWS PIIITILLI LIQNFKQDL VIWPSLFFW 
VVAFTFANS ALNPILYNM TL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IYSALipidFree Fatty AcidFFA4Homo sapiensTUG-891GDPchim(NtGi1L-Gq)/β1/γ22.952023-06-21doi.org/10.1038/s41422-023-00835-x
8IYS (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensTUG-891GDP2.952023-06-21doi.org/10.1038/s41422-023-00835-x
8H4IALipidFree Fatty AcidFFA4Homo sapiensDoconexent-chim(NtGi1-Gs)/β1/γ23.062023-06-21doi.org/10.1038/s41422-023-00835-x
8H4I (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensDoconexent-3.062023-06-21doi.org/10.1038/s41422-023-00835-x
8H4KALipidFree Fatty AcidFFA4Homo sapiensGW9508-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-06-21doi.org/10.1038/s41422-023-00835-x
8H4K (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensGW9508-3.12023-06-21doi.org/10.1038/s41422-023-00835-x
8H4LALipidFree Fatty AcidFFA4Homo sapiensDoconexent-chim(NtGi1-Gs-CtGq)/β1/γ23.072023-06-21doi.org/10.1038/s41422-023-00835-x
8H4L (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensDoconexent-3.072023-06-21doi.org/10.1038/s41422-023-00835-x
8T3OALipidFree Fatty AcidFFA4Homo sapiensTUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ23.062024-01-17doi.org/10.1126/sciadv.adj2384
8T3O (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-3.062024-01-17doi.org/10.1126/sciadv.adj2384
8T3QALipidFree Fatty AcidFFA4Homo sapiensDocosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ23.142024-01-24doi.org/10.1126/sciadv.adj2384
8T3Q (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensDocosa-4,7,10,13,16,19-Hexaenoic acid-3.142024-01-24doi.org/10.1126/sciadv.adj2384
8G59ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-chim(Gi1-CtGq)/β1/γ22.642023-03-08doi.org/10.1126/science.add6220
8G59 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-2.642023-03-08doi.org/10.1126/science.add6220
8ID3ALipidFree Fatty AcidFFA4Homo sapiens9-Hydroxystearic acid-Gi1/β1/γ23.12023-03-15doi.org/10.1126/science.add6220
8ID3 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiens9-Hydroxystearic acid-3.12023-03-15doi.org/10.1126/science.add6220
8ID4ALipidFree Fatty AcidFFA4Homo sapiensLinoleic acid-Gi1/β1/γ23.12023-03-15doi.org/10.1126/science.add6220
8ID4 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensLinoleic acid-3.12023-03-15doi.org/10.1126/science.add6220
8ID6ALipidFree Fatty AcidFFA4Homo sapiensOleic acid-Gi1/β1/γ22.82023-03-15doi.org/10.1126/science.add6220
8ID6 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensOleic acid-2.82023-03-15doi.org/10.1126/science.add6220
8ID8ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-Gi1/β1/γ232023-03-15doi.org/10.1126/science.add6220
8ID8 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-32023-03-15doi.org/10.1126/science.add6220
8ID9ALipidFree Fatty AcidFFA4Homo sapiensEicosapentaenoic acid-Gi1/β1/γ232023-03-15doi.org/10.1126/science.add6220
8ID9 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiensEicosapentaenoic acid-32023-03-15doi.org/10.1126/science.add6220




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ID6_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.