psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F27	3.09	Yes	Yes	1	0	5
2	L:L:?1	R:R:M118	9.57	Yes	No	0	0	7
3	L:L:?1	R:R:T119	3.74	Yes	Yes	1	0	5
4	L:L:?1	R:R:G122	5.79	Yes	No	0	0	7
5	L:L:?1	R:R:I126	3.62	Yes	No	1	0	8
6	L:L:?1	R:R:L173	5.85	Yes	Yes	1	0	5
7	L:L:?1	R:R:F177	3.09	Yes	Yes	1	0	5
8	L:L:?1	R:R:W198	4.82	Yes	Yes	1	0	7
9	L:L:?1	R:R:E204	5.6	Yes	No	1	0	5
10	L:L:?1	R:R:D208	10.33	Yes	No	0	0	5
11	L:L:?1	R:R:F211	6.18	Yes	Yes	1	0	5
12	L:L:?1	R:R:W277	5.78	Yes	No	1	0	9
13	L:L:?1	R:R:I284	7.24	Yes	No	0	0	5
14	L:L:?1	R:R:I287	6.04	Yes	No	0	0	5
15	L:L:?1	R:R:F303	3.09	Yes	Yes	1	0	4
16	R:R:Q182	R:R:T23	2.83	No	No	0	2	8
17	R:R:R183	R:R:T23	7.76	No	No	0	3	8
18	R:R:R24	R:R:T195	2.59	No	Yes	0	5	4
19	R:R:I197	R:R:R24	6.26	No	No	0	4	5
20	R:R:F25	R:R:P26	5.78	Yes	No	0	5	5
21	R:R:F25	R:R:F27	7.5	Yes	Yes	0	5	5
22	R:R:F25	R:R:I287	5.02	Yes	No	0	5	5
23	R:R:F25	R:R:Q290	5.86	Yes	No	0	5	4
24	R:R:L184	R:R:P26	3.28	Yes	No	0	2	5
25	R:R:F177	R:R:F27	6.43	Yes	Yes	1	5	5
26	R:R:F27	R:R:T195	2.59	Yes	Yes	0	5	4
27	R:R:F28	R:R:V95	10.49	Yes	No	0	8	6
28	R:R:F115	R:R:F28	3.22	Yes	Yes	1	5	8
29	R:R:F28	R:R:F303	3.22	Yes	Yes	1	8	4
30	R:R:F28	R:R:V307	2.62	Yes	No	1	8	5
31	R:R:I193	R:R:S29	3.1	No	No	0	4	9
32	R:R:D30	R:R:V31	2.92	No	No	0	6	6
33	R:R:D30	R:R:P300	17.71	No	No	0	6	4
34	R:R:L184	R:R:V31	2.98	Yes	No	0	2	6
35	R:R:K32	R:R:R36	3.71	No	No	0	3	4
36	R:R:A40	R:R:K32	3.21	No	No	0	5	3
37	R:R:D34	R:R:H35	17.65	No	No	0	3	3
38	R:R:L37	R:R:R36	8.5	No	No	0	3	4
39	R:R:A40	R:R:W100	7.78	No	No	0	5	5
40	R:R:E43	R:R:R99	13.96	No	No	2	5	4
41	R:R:E43	R:R:F304	16.32	No	Yes	2	5	4
42	R:R:L96	R:R:T44	4.42	No	No	0	6	6
43	R:R:T44	R:R:W100	3.64	No	No	0	6	5
44	R:R:I92	R:R:L47	2.85	Yes	Yes	2	7	6
45	R:R:L47	R:R:L96	5.54	Yes	No	2	6	6
46	R:R:F304	R:R:L47	3.65	Yes	Yes	2	4	6
47	R:R:F51	R:R:I89	5.02	No	Yes	0	6	6
48	R:R:I89	R:R:S54	9.29	Yes	No	2	6	8
49	R:R:S314	R:R:S54	6.52	No	No	2	9	8
50	R:R:L55	R:R:V59	2.98	No	No	0	5	3
51	R:R:F82	R:R:N58	3.62	Yes	Yes	0	9	9
52	R:R:D85	R:R:N58	9.42	Yes	Yes	0	9	9
53	R:R:L86	R:R:N58	6.87	No	Yes	0	7	9
54	R:R:N58	R:R:P318	6.52	Yes	No	0	9	9
55	R:R:A61	R:R:F82	6.93	No	Yes	0	8	9
56	R:R:L79	R:R:V65	2.98	No	No	0	5	7
57	R:R:R69	R:R:R70	4.26	No	No	0	7	7
58	R:R:E135	R:R:T74	7.06	No	No	0	8	8
59	R:R:C76	R:R:R155	2.79	No	Yes	0	5	6
60	R:R:E135	R:R:L77	5.3	No	No	0	8	7
61	R:R:F82	R:R:V78	6.55	Yes	No	0	9	8
62	R:R:N80	R:R:T128	7.31	No	No	0	9	8
63	R:R:L159	R:R:N80	5.49	No	No	0	7	9
64	R:R:N80	R:R:W163	6.78	No	No	0	9	9
65	R:R:L81	R:R:T128	5.9	No	No	0	9	8
66	R:R:L129	R:R:L81	4.15	No	No	5	8	9
67	R:R:L81	R:R:N317	4.12	No	No	5	9	9
68	R:R:A84	R:R:V124	3.39	No	No	0	8	7
69	R:R:D85	R:R:T125	4.34	Yes	No	0	9	9
70	R:R:D85	R:R:S314	2.94	Yes	No	0	9	9
71	R:R:D85	R:R:N317	8.08	Yes	No	0	9	9
72	R:R:L87	R:R:S121	7.51	No	No	0	6	8
73	R:R:F88	R:R:M118	3.73	Yes	No	0	7	7
74	R:R:F88	R:R:S121	5.28	Yes	No	0	7	8
75	R:R:F88	R:R:T310	2.59	Yes	No	0	7	8
76	R:R:F311	R:R:F88	9.65	No	Yes	0	7	7
77	R:R:I89	R:R:I92	2.94	Yes	Yes	2	6	7
78	R:R:I89	R:R:S314	9.29	Yes	No	2	6	9
79	R:R:A91	R:R:M118	3.22	No	No	0	6	7
80	R:R:I92	R:R:P93	3.39	Yes	No	0	7	9
81	R:R:I92	R:R:L96	2.85	Yes	No	2	7	6
82	R:R:F311	R:R:I92	3.77	No	Yes	0	7	7
83	R:R:L106	R:R:L94	2.77	No	No	0	6	5
84	R:R:L114	R:R:L94	8.3	No	No	0	6	5
85	R:R:F304	R:R:V95	2.62	Yes	No	0	4	6
86	R:R:V98	R:R:W104	8.58	No	Yes	0	5	9
87	R:R:F304	R:R:R99	12.83	Yes	No	2	4	4
88	R:R:L105	R:R:T101	5.9	No	No	0	4	4
89	R:R:E102	R:R:I191	2.73	No	No	0	4	4
90	R:R:C111	R:R:W104	6.53	No	Yes	1	9	9
91	R:R:V179	R:R:W104	6.13	No	Yes	1	5	9
92	R:R:C194	R:R:W104	11.75	Yes	Yes	1	9	9
93	R:R:A110	R:R:L106	4.73	No	No	0	5	6
94	R:R:G107	R:R:P108	4.06	No	No	0	8	3
95	R:R:C111	R:R:V179	3.42	No	No	1	9	5
96	R:R:C111	R:R:C194	7.28	No	Yes	1	9	9
97	R:R:F115	R:R:L173	3.65	Yes	Yes	1	5	5
98	R:R:F115	R:R:F177	20.36	Yes	Yes	1	5	5
99	R:R:C194	R:R:F115	2.79	Yes	Yes	1	9	5
100	R:R:C174	R:R:Y116	8.06	No	No	0	4	5
101	R:R:A170	R:R:T119	3.36	No	Yes	0	7	5
102	R:R:L173	R:R:T119	4.42	Yes	Yes	1	5	5
103	R:R:F211	R:R:T119	2.59	Yes	Yes	1	5	5
104	R:R:S123	R:R:S166	3.26	No	No	0	6	8
105	R:R:F211	R:R:S123	2.64	Yes	No	1	5	6
106	R:R:N215	R:R:S123	2.98	No	No	1	6	6
107	R:R:V124	R:R:W163	9.81	No	No	0	7	9
108	R:R:S166	R:R:V124	3.23	No	No	0	8	7
109	R:R:I126	R:R:P219	3.39	No	No	0	8	9
110	R:R:I126	R:R:W277	5.87	No	No	1	8	9
111	R:R:L129	R:R:N317	2.75	No	No	5	8	9
112	R:R:L129	R:R:Y321	5.86	No	No	0	8	9
113	R:R:A130	R:R:P219	3.74	No	No	0	7	9
114	R:R:R136	R:R:V132	2.62	No	No	0	9	8
115	R:R:S133	R:R:Y227	11.45	No	Yes	0	8	9
116	R:R:L134	R:R:V222	2.98	No	No	0	5	6
117	R:R:E135	R:R:R155	3.49	No	Yes	0	8	6
118	R:R:R136	R:R:Y227	4.12	No	Yes	0	9	9
119	R:R:M137	R:R:S226	6.13	No	No	0	8	5
120	R:R:K229	R:R:M137	8.64	No	No	0	5	8
121	R:R:I230	R:R:M137	4.37	No	No	0	8	8
122	R:R:C139	R:R:H142	7.37	No	Yes	0	8	5
123	R:R:I140	R:R:V141	3.07	No	No	0	8	6
124	R:R:G149	R:R:H142	4.77	No	Yes	6	4	5
125	R:R:H142	R:R:P150	3.05	Yes	No	6	5	6
126	R:R:R145	R:R:V147	6.54	No	No	0	5	5
127	R:R:G149	R:R:P150	4.06	No	No	6	4	6
128	R:R:P150	R:R:R155	8.65	No	Yes	0	6	6
129	R:R:A154	R:R:R155	2.77	No	Yes	0	5	6
130	R:R:A169	R:R:Y165	2.67	No	Yes	0	5	4
131	R:R:N215	R:R:Y165	8.14	No	Yes	0	6	4
132	R:R:F176	R:R:P172	4.33	No	Yes	0	5	8
133	R:R:P172	R:R:W198	4.05	Yes	Yes	1	8	7
134	R:R:P172	R:R:W207	4.05	Yes	Yes	1	8	6
135	R:R:F177	R:R:L173	6.09	Yes	Yes	1	5	5
136	R:R:L173	R:R:W207	4.56	Yes	Yes	1	5	6
137	R:R:F176	R:R:V175	10.49	No	No	0	5	4
138	R:R:F176	R:R:P199	2.89	No	No	0	5	6
139	R:R:C194	R:R:F177	2.79	Yes	Yes	1	9	5
140	R:R:F177	R:R:L196	20.7	Yes	No	0	5	5
141	R:R:I197	R:R:R178	3.76	No	No	0	4	4
142	R:R:S192	R:R:V179	3.23	No	No	0	3	5
143	R:R:P181	R:R:V180	3.53	No	No	0	2	4
144	R:R:P185	R:R:R183	4.32	No	No	0	1	3
145	R:R:L184	R:R:P185	4.93	Yes	No	0	2	1
146	R:R:I191	R:R:L184	2.85	No	Yes	0	4	2
147	R:R:I193	R:R:T195	3.04	No	Yes	0	4	4
148	R:R:L196	R:R:W198	9.11	No	Yes	0	5	7
149	R:R:P199	R:R:W198	5.4	No	Yes	0	6	7
150	R:R:E204	R:R:W198	32.71	No	Yes	1	5	7
151	R:R:W198	R:R:W207	5.62	Yes	Yes	1	7	6
152	R:R:P202	R:R:T200	3.5	No	No	0	3	3
153	R:R:I201	R:R:P202	3.39	No	No	0	4	3
154	R:R:E204	R:R:L288	2.65	No	No	0	5	4
155	R:R:D208	R:R:W207	4.47	No	Yes	0	5	6
156	R:R:F211	R:R:W207	5.01	Yes	Yes	1	5	6
157	R:R:D208	R:R:L288	6.79	No	No	0	5	4
158	R:R:F211	R:R:N215	8.46	Yes	No	1	5	6
159	R:R:I281	R:R:V212	3.07	No	No	0	7	6
160	R:R:L214	R:R:T213	2.95	No	No	0	4	5
161	R:R:F216	R:R:F273	3.22	Yes	Yes	3	8	9
162	R:R:F216	R:R:F274	4.29	Yes	No	3	8	6
163	R:R:F216	R:R:S278	5.28	Yes	No	0	8	7
164	R:R:F216	R:R:I281	8.79	Yes	No	0	8	7
165	R:R:P219	R:R:V218	3.53	No	No	0	9	5
166	R:R:F273	R:R:G220	4.52	Yes	No	3	9	6
167	R:R:F274	R:R:G220	3.01	No	No	3	6	6
168	R:R:F273	R:R:I223	5.02	Yes	No	0	9	8
169	R:R:M270	R:R:V224	3.04	No	No	0	8	5
170	R:R:L266	R:R:Y227	5.86	No	Yes	0	8	9
171	R:R:L269	R:R:Y227	4.69	No	Yes	0	8	9
172	R:R:M270	R:R:Y227	5.99	No	Yes	0	8	9
173	R:R:L231	R:R:L266	4.15	No	No	0	6	8
174	R:R:L262	R:R:T234	4.42	No	No	0	8	8
175	R:R:F263	R:R:K235	3.72	No	No	0	7	5
176	R:R:K239	R:R:T242	4.5	No	No	0	5	4
177	R:R:K239	R:R:V243	6.07	No	No	0	5	2
178	R:R:L241	R:R:Y247	14.07	No	No	0	5	4
179	R:R:Q252	R:R:T242	2.83	No	No	0	2	4
180	R:R:L245	R:R:S244	3	No	No	0	3	5
181	R:R:S248	R:R:S250	3.26	No	No	0	6	5
182	R:R:H251	R:R:S248	12.55	No	No	0	2	6
183	R:R:D259	R:R:S256	7.36	No	No	0	7	4
184	R:R:F260	R:R:Q258	3.51	Yes	No	7	6	6
185	R:R:Q258	R:R:R261	4.67	No	No	7	6	8
186	R:R:D259	R:R:F263	13.14	No	No	0	7	7
187	R:R:F260	R:R:R261	3.21	Yes	No	7	6	8
188	R:R:F260	R:R:R264	3.21	Yes	No	0	6	7
189	R:R:L262	R:R:L266	4.15	No	No	0	8	8
190	R:R:L269	R:R:T265	2.95	No	No	0	8	8
191	R:R:M323	R:R:T265	3.01	Yes	No	0	5	8
192	R:R:L269	R:R:L320	2.77	No	No	0	8	8
193	R:R:L320	R:R:S272	3	No	No	0	8	6
194	R:R:F273	R:R:F274	13.93	Yes	No	3	9	6
195	R:R:F309	R:R:M276	4.98	No	Yes	0	7	8
196	R:R:M276	R:R:N313	12.62	Yes	No	0	8	9
197	R:R:L316	R:R:M276	2.83	No	Yes	0	6	8
198	R:R:N313	R:R:W277	23.73	No	No	0	9	9
199	R:R:F309	R:R:P279	5.78	No	No	0	7	9
200	R:R:I280	R:R:I281	2.94	No	No	0	6	7
201	R:R:I280	R:R:T310	3.04	No	No	0	6	8
202	R:R:F303	R:R:T283	2.59	Yes	No	0	4	5
203	R:R:T283	R:R:V306	6.35	No	No	0	5	6
204	R:R:I298	R:R:Q290	5.49	No	No	0	3	4
205	R:R:D295	R:R:K293	9.68	No	No	0	3	1
206	R:R:I298	R:R:L302	4.28	No	No	0	3	5
207	R:R:S301	R:R:W299	6.18	No	No	0	2	4
208	R:R:F303	R:R:V307	3.93	Yes	No	1	4	5
209	R:R:F304	R:R:W305	11.02	Yes	No	0	4	4
210	R:R:F311	R:R:V307	5.24	No	No	0	7	5
211	R:R:L316	R:R:L320	4.15	No	No	0	6	8
212	R:R:M323	R:R:T324	4.52	Yes	No	0	5	7
213	R:R:V255	R:R:Y247	2.52	No	No	0	5	4
214	R:R:F267	R:R:M270	2.49	No	No	0	5	8
215	R:R:F82	R:R:L62	2.44	Yes	No	0	9	6
216	R:R:F115	R:R:L114	2.44	Yes	No	0	5	6
217	R:R:F263	R:R:L231	2.44	No	No	0	7	6
218	R:R:F82	R:R:N322	2.42	Yes	No	0	9	7
219	R:R:L127	R:R:Y165	2.34	No	Yes	0	6	4
220	R:R:L214	R:R:Y165	2.34	No	Yes	0	4	4
221	R:R:L120	R:R:W163	2.28	No	No	0	5	9
222	R:R:D30	R:R:W299	2.23	No	No	0	6	4
223	R:R:H251	R:R:Y247	2.18	No	No	0	2	4
224	R:R:G203	R:R:P202	2.03	No	No	0	3	3
225	R:R:P199	R:R:T200	1.75	No	No	0	6	3
226	R:R:G33	R:R:K32	1.74	No	No	0	3	3
227	R:R:A315	R:R:S54	1.71	No	No	0	6	8
228	R:R:G57	R:R:L56	1.71	No	No	0	9	4
229	R:R:G107	R:R:L106	1.71	No	No	0	8	6
230	R:R:C174	R:R:V175	1.71	No	No	0	4	4
231	R:R:A315	R:R:V53	1.7	No	No	0	6	5
232	R:R:L171	R:R:P172	1.64	No	Yes	0	5	8
233	R:R:A103	R:R:I191	1.62	No	No	0	5	4
234	R:R:S121	R:R:V117	1.62	No	No	0	8	4
235	R:R:S226	R:R:V222	1.62	No	No	0	5	6
236	R:R:A312	R:R:M276	1.61	No	Yes	0	5	8
237	R:R:V38	R:R:V42	1.6	No	No	0	3	5
238	R:R:V59	R:R:V63	1.6	No	No	0	3	4
239	R:R:V218	R:R:V222	1.6	No	No	0	5	6
240	R:R:T45	R:R:V46	1.59	No	No	0	4	6
241	R:R:T195	R:R:V180	1.59	Yes	No	0	4	4
242	R:R:A308	R:R:L47	1.58	No	Yes	0	4	6
243	R:R:A131	R:R:L77	1.58	No	No	0	7	7
244	R:R:A167	R:R:L120	1.58	No	No	0	3	5
245	R:R:A131	R:R:L158	1.58	No	No	0	7	5
246	R:R:T44	R:R:T45	1.57	No	No	0	6	4
247	R:R:I162	R:R:S166	1.55	No	No	0	7	8
248	R:R:I50	R:R:V46	1.54	No	No	0	7	6
249	R:R:H112	R:R:P108	1.53	No	No	0	7	3
250	R:R:G72	R:R:R71	1.5	No	No	0	7	7
251	R:R:G149	R:R:R148	1.5	No	No	0	4	4
252	R:R:G151	R:R:R152	1.5	No	No	0	7	3
253	R:R:L214	R:R:S210	1.5	No	No	0	4	4
254	R:R:L77	R:R:V132	1.49	No	No	0	7	8
255	R:R:L113	R:R:V109	1.49	No	No	0	5	2
256	R:R:I201	R:R:I205	1.47	No	No	0	4	4
257	R:R:L217	R:R:T213	1.47	No	No	0	4	5
258	R:R:I275	R:R:M276	1.46	No	Yes	0	5	8
259	R:R:I319	R:R:M323	1.46	No	Yes	0	7	5
260	R:R:I233	R:R:K229	1.45	No	No	0	5	5
261	R:R:Q252	R:R:S256	1.44	No	No	0	2	4
262	R:R:I289	R:R:L296	1.43	No	No	0	4	5
263	R:R:I298	R:R:L296	1.43	No	No	0	3	5
264	R:R:I287	R:R:N291	1.42	No	No	0	5	2
265	R:R:L268	R:R:M323	1.41	No	Yes	0	6	5
266	R:R:L55	R:R:L86	1.38	No	No	0	5	7
267	R:R:L62	R:R:L79	1.38	No	No	0	6	5
268	R:R:L325	R:R:L64	1.38	No	No	4	8	7
269	R:R:H142	R:R:V147	1.38	Yes	No	0	5	5
270	R:R:L241	R:R:L245	1.38	No	No	0	5	3
271	R:R:L286	R:R:L296	1.38	No	No	0	5	5
272	R:R:L64	R:R:N322	1.37	No	No	4	7	7
273	R:R:I140	R:R:Q144	1.37	No	No	0	8	6
274	R:R:I253	R:R:Q252	1.37	No	No	0	3	2
275	R:R:L325	R:R:N322	1.37	No	No	4	8	7
276	R:R:R238	R:R:S256	1.32	No	No	0	4	4
277	R:R:R238	R:R:V255	1.31	No	No	0	4	5
278	R:R:Q257	R:R:Q258	1.28	No	No	0	5	6
279	R:R:V42	R:R:W305	1.23	No	No	0	5	4
280	R:R:L64	R:R:R68	1.21	No	No	4	7	6
281	R:R:L325	R:R:R68	1.21	No	No	4	8	6
282	R:R:L245	R:R:R240	1.21	No	No	0	3	3
283	R:R:D259	R:R:F260	1.19	No	Yes	0	7	6
284	R:R:Q257	R:R:R254	1.17	No	No	0	5	4
285	R:R:E190	R:R:R183	1.16	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.58867	15	1	0
2	R:R:F25	6.04	4	0	5
3	R:R:F27	4.9025	4	1	5
4	R:R:F28	4.8875	4	1	8
5	R:R:L47	3.405	4	2	6
6	R:R:N58	6.6075	4	0	9
7	R:R:F82	4.392	5	0	9
8	R:R:D85	6.195	4	0	9
9	R:R:F88	5.3125	4	0	7
10	R:R:I89	6.635	4	2	6
11	R:R:I92	3.16	5	2	7
12	R:R:W104	8.2475	4	1	9
13	R:R:F115	6.492	5	1	5
14	R:R:T119	3.5275	4	1	5
15	R:R:H142	4.1425	4	6	5
16	R:R:R155	4.425	4	0	6
17	R:R:Y165	3.8725	4	0	4
18	R:R:P172	3.5175	4	1	8
19	R:R:L173	4.914	5	1	5
20	R:R:F177	9.91	6	1	5
21	R:R:L184	3.51	4	0	2
22	R:R:C194	6.1525	4	1	9
23	R:R:T195	2.4525	4	0	4
24	R:R:W198	10.285	6	1	7
25	R:R:W207	4.742	5	1	6
26	R:R:F211	4.976	5	1	5
27	R:R:F216	5.395	4	3	8
28	R:R:Y227	6.422	5	0	9
29	R:R:F260	2.78	4	7	6
30	R:R:F273	6.6725	4	3	9
31	R:R:M276	4.7	5	0	8
32	R:R:F303	3.2075	4	1	4
33	R:R:F304	9.288	5	2	4
34	R:R:M323	2.6	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F27	44.3078	3.09	Yes	Yes	1	0	5
2	R:R:F25	R:R:F27	36.4315	7.5	Yes	Yes	0	5	5
3	R:R:F25	R:R:P26	46.9788	5.78	Yes	No	0	5	5
4	R:R:L184	R:R:P26	43.9262	3.28	Yes	No	0	2	5
5	R:R:L184	R:R:P185	15.9405	4.93	Yes	No	0	2	1
6	R:R:P185	R:R:R183	12.7741	4.32	No	No	0	1	3
7	L:L:?1	R:R:I287	34.461	6.04	Yes	No	0	0	5
8	R:R:F25	R:R:I287	31.6875	5.02	Yes	No	0	5	5
9	R:R:F27	R:R:T195	14.027	2.59	Yes	Yes	0	5	4
10	R:R:F25	R:R:Q290	19.0956	5.86	Yes	No	0	5	4
11	R:R:F115	R:R:L173	10.2113	3.65	Yes	Yes	1	5	5
12	L:L:?1	R:R:F303	58.5113	3.09	Yes	Yes	1	0	4
13	R:R:F303	R:R:V307	46.1587	3.93	Yes	No	1	4	5
14	R:R:L184	R:R:V31	15.9405	2.98	Yes	No	0	2	6
15	R:R:D30	R:R:V31	12.7741	2.92	No	No	0	6	6
16	L:L:?1	R:R:M118	64.6848	9.57	Yes	No	0	0	7
17	R:R:F88	R:R:M118	63.0275	3.73	Yes	No	0	7	7
18	R:R:F311	R:R:F88	50.299	9.65	No	Yes	0	7	7
19	R:R:F311	R:R:I92	97.198	3.77	No	Yes	0	7	7
20	R:R:I92	R:R:L96	27.6838	2.85	Yes	No	2	7	6
21	R:R:L96	R:R:T44	26.9321	4.42	No	No	0	6	6
22	R:R:T44	R:R:W100	16.2936	3.64	No	No	0	6	5
23	R:R:A40	R:R:W100	13.6056	7.78	No	No	0	5	5
24	R:R:A40	R:R:K32	10.9061	3.21	No	No	0	5	3
25	R:R:F311	R:R:V307	51.3469	5.24	No	No	0	7	5
26	R:R:F28	R:R:F303	10.2625	3.22	Yes	Yes	1	8	4
27	R:R:F28	R:R:V95	13.5087	10.49	Yes	No	0	8	6
28	R:R:F304	R:R:V95	12.4267	2.62	Yes	No	0	4	6
29	R:R:I89	R:R:I92	66.8432	2.94	Yes	Yes	2	6	7
30	R:R:I89	R:R:S314	55.1626	9.29	Yes	No	2	6	9
31	R:R:D85	R:R:S314	53.5167	2.94	Yes	No	0	9	9
32	R:R:D85	R:R:N58	43.1915	9.42	Yes	Yes	0	9	9
33	R:R:L86	R:R:N58	10.496	6.87	No	Yes	0	7	9
34	R:R:F82	R:R:N58	28.259	3.62	Yes	Yes	0	9	9
35	L:L:?1	R:R:W277	96.8392	5.78	Yes	No	1	0	9
36	R:R:N313	R:R:W277	100	23.73	No	No	0	9	9
37	R:R:M276	R:R:N313	98.8496	12.62	Yes	No	0	8	9
38	R:R:L316	R:R:M276	92.9267	2.83	No	Yes	0	6	8
39	R:R:L316	R:R:L320	91.708	4.15	No	No	0	6	8
40	R:R:L269	R:R:L320	89.2363	2.77	No	No	0	8	8
41	R:R:L269	R:R:Y227	81.5479	4.69	No	Yes	0	8	9
42	R:R:R136	R:R:Y227	30.463	4.12	No	Yes	0	9	9
43	R:R:R136	R:R:V132	28.7545	2.62	No	No	0	9	8
44	R:R:L77	R:R:V132	27.0346	1.49	No	No	0	7	8
45	R:R:E135	R:R:L77	21.8065	5.3	No	No	0	8	7
46	R:R:E135	R:R:R155	18.2584	3.49	No	Yes	0	8	6
47	L:L:?1	R:R:F211	32.3538	6.18	Yes	Yes	1	0	5
48	R:R:F211	R:R:S123	19.1981	2.64	Yes	No	1	5	6
49	R:R:S123	R:R:S166	19.2494	3.26	No	No	0	6	8
50	R:R:S166	R:R:V124	16.2879	3.23	No	No	0	8	7
51	R:R:V124	R:R:W163	13.4176	9.81	No	No	0	7	9
52	R:R:D85	R:R:N317	10.4106	8.08	Yes	No	0	9	9
53	R:R:F88	R:R:T310	17.8484	2.59	Yes	No	0	7	8
54	R:R:F115	R:R:L114	18.0534	2.44	Yes	No	0	5	6
55	R:R:L114	R:R:L94	15.5077	8.3	No	No	0	6	5
56	R:R:L106	R:R:L94	12.9506	2.77	No	No	0	6	5
57	L:L:?1	R:R:F177	15.0692	3.09	Yes	Yes	1	0	5
58	R:R:F115	R:R:F177	10.1714	20.36	Yes	Yes	1	5	5
59	L:L:?1	R:R:W198	29.4948	4.82	Yes	Yes	1	0	7
60	R:R:F176	R:R:V175	10.6897	10.49	No	No	0	5	4
61	R:R:P199	R:R:W198	18.697	5.4	No	Yes	0	6	7
62	R:R:F211	R:R:N215	14.8471	8.46	Yes	No	1	5	6
63	L:L:?1	R:R:I126	15.8665	3.62	Yes	No	1	0	8
64	R:R:I126	R:R:P219	18.3894	3.39	No	No	0	8	9
65	R:R:P219	R:R:V218	14.8015	3.53	No	No	0	9	5
66	R:R:V218	R:R:V222	12.9905	1.6	No	No	0	5	6
67	R:R:P150	R:R:R155	12.8595	8.65	No	Yes	0	6	6
68	R:R:N215	R:R:Y165	14.3858	8.14	No	Yes	0	6	4
69	R:R:P199	R:R:T200	10.5587	1.75	No	No	0	6	3
70	R:R:I280	R:R:T310	16.2822	3.04	No	No	0	6	8
71	R:R:I280	R:R:I281	14.7047	2.94	No	No	0	6	7
72	R:R:F216	R:R:I281	11.5155	8.79	Yes	No	0	8	7
73	R:R:L266	R:R:Y227	49.9516	5.86	No	Yes	0	8	9
74	R:R:L231	R:R:L266	45.3272	4.15	No	No	0	6	8
75	R:R:F263	R:R:L231	43.7041	2.44	No	No	0	7	6
76	R:R:D259	R:R:F263	40.4522	13.14	No	No	0	7	7
77	R:R:D259	R:R:S256	28.7317	7.36	No	No	0	7	4
78	R:R:R238	R:R:S256	18.2414	1.32	No	No	0	4	4
79	R:R:R238	R:R:V255	16.5955	1.31	No	No	0	4	5
80	R:R:V255	R:R:Y247	14.8015	2.52	No	No	0	5	4
81	R:R:D259	R:R:F260	11.1681	1.19	No	Yes	0	7	6
82	R:R:I298	R:R:Q290	15.9405	5.49	No	No	0	3	4
83	R:R:F82	R:R:N322	12.9165	2.42	Yes	No	0	9	7
84	R:R:F115	R:R:F28	10.3651	3.22	Yes	Yes	1	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F27	3.09	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M118	9.57	1	Yes	No	0	7	0	1
L:L:?1	R:R:T119	3.74	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:G122	5.79	1	Yes	No	0	7	0	1
L:L:?1	R:R:I126	3.62	1	Yes	No	0	8	0	1
L:L:?1	R:R:L173	5.85	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F177	3.09	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W198	4.82	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:E204	5.6	1	Yes	No	0	5	0	1
L:L:?1	R:R:D208	10.33	1	Yes	No	0	5	0	1
L:L:?1	R:R:F211	6.18	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W277	5.78	1	Yes	No	0	9	0	1
L:L:?1	R:R:I284	7.24	1	Yes	No	0	5	0	1
L:L:?1	R:R:I287	6.04	1	Yes	No	0	5	0	1
L:L:?1	R:R:F303	3.09	1	Yes	Yes	0	4	0	1
R:R:F25	R:R:F27	7.5	0	Yes	Yes	5	5	2	1
R:R:F25	R:R:I287	5.02	0	Yes	No	5	5	2	1
R:R:F177	R:R:F27	6.43	1	Yes	Yes	5	5	1	1
R:R:F27	R:R:T195	2.59	1	Yes	Yes	5	4	1	2
R:R:F115	R:R:F28	3.22	1	Yes	Yes	5	8	2	2
R:R:F28	R:R:F303	3.22	1	Yes	Yes	8	4	2	1
R:R:F28	R:R:V307	2.62	1	Yes	No	8	5	2	2
R:R:F88	R:R:M118	3.73	0	Yes	No	7	7	2	1
R:R:A91	R:R:M118	3.22	0	No	No	6	7	2	1
R:R:F115	R:R:L173	3.65	1	Yes	Yes	5	5	2	1
R:R:F115	R:R:F177	20.36	1	Yes	Yes	5	5	2	1
R:R:C194	R:R:F115	2.79	1	Yes	Yes	9	5	2	2
R:R:A170	R:R:T119	3.36	0	No	Yes	7	5	2	1
R:R:L173	R:R:T119	4.42	1	Yes	Yes	5	5	1	1
R:R:F211	R:R:T119	2.59	1	Yes	Yes	5	5	1	1
R:R:F211	R:R:S123	2.64	1	Yes	No	5	6	1	2
R:R:N215	R:R:S123	2.98	1	No	No	6	6	2	2
R:R:I126	R:R:P219	3.39	1	No	No	8	9	1	2
R:R:I126	R:R:W277	5.87	1	No	No	8	9	1	1
R:R:P172	R:R:W198	4.05	1	Yes	Yes	8	7	2	1
R:R:P172	R:R:W207	4.05	1	Yes	Yes	8	6	2	2
R:R:F177	R:R:L173	6.09	1	Yes	Yes	5	5	1	1
R:R:L173	R:R:W207	4.56	1	Yes	Yes	5	6	1	2
R:R:C194	R:R:F177	2.79	1	Yes	Yes	9	5	2	1
R:R:F177	R:R:L196	20.7	1	Yes	No	5	5	1	2
R:R:L196	R:R:W198	9.11	0	No	Yes	5	7	2	1
R:R:P199	R:R:W198	5.4	0	No	Yes	6	7	2	1
R:R:E204	R:R:W198	32.71	1	No	Yes	5	7	1	1
R:R:W198	R:R:W207	5.62	1	Yes	Yes	7	6	1	2
R:R:E204	R:R:L288	2.65	1	No	No	5	4	1	2
R:R:D208	R:R:W207	4.47	0	No	Yes	5	6	1	2
R:R:F211	R:R:W207	5.01	1	Yes	Yes	5	6	1	2
R:R:D208	R:R:L288	6.79	0	No	No	5	4	1	2
R:R:F211	R:R:N215	8.46	1	Yes	No	5	6	1	2
R:R:N313	R:R:W277	23.73	0	No	No	9	9	2	1
R:R:F303	R:R:T283	2.59	1	Yes	No	4	5	1	2
R:R:F303	R:R:V307	3.93	1	Yes	No	4	5	1	2
R:R:I287	R:R:N291	1.42	0	No	No	5	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8H4K_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.59
Number of Linked Nodes	261
Number of Links	285
Number of Hubs	34
Number of Links mediated by Hubs	129
Number of Communities	7
Number of Nodes involved in Communities	48
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	47528
Length Of Smallest Path	3
Average Path Length	13.3525
Length of Longest Path	31
Minimum Path Strength	1.225
Average Path Strength	5.43822
Maximum Path Strength	20.91
Minimum Path Correlation	0.7
Average Path Correlation	0.941304
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	59.009
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.1229
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein binding • binding • arrestin family protein binding • fatty acid binding • organic acid binding • ion binding • anion binding • lipid binding • carboxylic acid binding • monocarboxylic acid binding • small molecule binding • taste receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of localization • nitrogen compound transport • regulation of hormone secretion • regulation of cellular process • regulation of peptide secretion • transport • signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of transport • hormone secretion • somatostatin secretion • negative regulation of cell communication • cell communication • negative regulation of peptide secretion • negative regulation of somatostatin secretion • localization • peptide secretion • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of peptide hormone secretion • regulation of biological process • regulation of signaling • negative regulation of peptide hormone secretion • secretion • regulation of transport • regulation of hormone levels • regulation of peptide transport • cell-cell signaling • export from cell • establishment of localization • regulation of secretion • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • hexose transmembrane transport • carbohydrate transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • multicellular organismal process • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • ghrelin secretion • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • developmental process • regulation of osteoblast differentiation • cellular developmental process • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • cell differentiation • phospholipase C-activating G protein-coupled receptor signaling pathway • fat cell differentiation • positive regulation of brown fat cell differentiation • positive regulation of fat cell differentiation • regulation of brown fat cell differentiation • brown fat cell differentiation • regulation of fat cell differentiation • glucagon secretion • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • regulation of glucagon secretion • positive regulation of peptide secretion • positive regulation of glucagon secretion • positive regulation of peptide hormone secretion • positive regulation of transport • white fat cell differentiation • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle • cytoplasm • vesicle • endocytic vesicle • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • endosome membrane • endosome • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • intracellular membraneless organelle • ciliary basal body • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • midbody • nucleus • membrane-enclosed lumen • nucleolus • intracellular organelle lumen • organelle lumen • nuclear lumen • cell cortex • centrosome • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WPT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WPT
Name	3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid
Synonyms
Identifier
Formula	C22 H21 N O3
Molecular Weight	347.407
SMILES
PubChem	11595431
Formal Charge	0
Total Atoms	47
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5NUL3
Sequence	>8H4K_nogp_Chain_R T R F P F F S D V K G D H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R R R R G A T A C L V L N L F C A D L L F I S A I P L V L A V R W T E A W L L G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H L Q R G V R G P G R R A R A V L L A L I W G Y S A V A A L P L C V F F R V V P Q R L P E I S I C T L I W P T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L A Y S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q D L V I W P S L F F W V V A F T F A N S A L N P I L Y N M T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G59	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(Gi1-CtGq)/β1/γ2	2.64	2023-03-08	doi.org/10.1126/science.add6220
	8G59 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		2.64	2023-03-08	doi.org/10.1126/science.add6220
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID4 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID6	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-	Gi1/β1/γ2	2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID6 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Oleic acid	-		2.8	2023-03-15	doi.org/10.1126/science.add6220
	8ID8	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID8 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Icosapent	-	Gi1/β1/γ2	3	2023-03-15	doi.org/10.1126/science.add6220
	8ID9 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Icosapent	-		3	2023-03-15	doi.org/10.1126/science.add6220
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8IYS	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP	chim(NtGi1L-Gq)/β1/γ2	2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8IYS (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	GDP		2.95	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8T3O	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3O (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	TUG-891	-		3.06	2024-01-17	doi.org/10.1126/sciadv.adj2384
	8T3Q	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3Q (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.14	2024-01-24	doi.org/10.1126/sciadv.adj2384

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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