psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D94	7.73	Yes	No	1	0	8
2	L:L:?1	R:R:Y95	21	Yes	No	0	0	8
3	L:L:?1	R:R:C98	10.34	Yes	No	0	0	8
4	L:L:?1	R:R:E182	10.79	Yes	Yes	1	0	8
5	L:L:?1	R:R:W316	7.42	Yes	Yes	1	0	9
6	L:L:?1	R:R:F344	17.85	Yes	No	1	0	6
7	L:L:?1	R:R:Q347	16.25	Yes	No	1	0	8
8	L:L:?1	R:R:W348	7.42	Yes	Yes	1	0	8
9	R:R:L12	R:R:T14	4.42	No	No	0	3	5
10	R:R:L12	R:R:R15	9.72	No	No	0	3	3
11	R:R:T14	R:R:T17	3.14	No	No	0	5	3
12	R:R:F78	R:R:R15	6.41	Yes	No	0	5	3
13	R:R:L18	R:R:L77	5.54	No	Yes	0	5	6
14	R:R:F20	R:R:L24	7.31	No	No	0	4	5
15	R:R:L77	R:R:M22	4.24	Yes	No	0	6	7
16	R:R:M22	R:R:W345	8.14	No	Yes	0	7	8
17	R:R:F349	R:R:V25	6.55	No	No	0	4	7
18	R:R:A26	R:R:I69	6.5	No	Yes	0	7	8
19	R:R:F27	R:R:L31	7.31	No	No	0	5	4
20	R:R:A28	R:R:F352	5.55	No	No	0	4	6
21	R:R:G65	R:R:I29	3.53	No	No	0	8	8
22	R:R:F352	R:R:I29	5.02	No	No	0	6	8
23	R:R:F62	R:R:M30	6.22	No	No	0	8	6
24	R:R:M30	R:R:V66	6.09	No	No	0	6	5
25	R:R:D61	R:R:N33	6.73	Yes	No	4	9	9
26	R:R:F62	R:R:N33	4.83	No	No	0	8	9
27	R:R:N33	R:R:P355	6.52	No	No	4	9	9
28	R:R:F369	R:R:L35	3.65	Yes	No	0	8	8
29	R:R:A58	R:R:V36	3.39	No	No	0	9	9
30	R:R:F365	R:R:V36	3.93	Yes	No	0	8	9
31	R:R:I37	R:R:L55	4.28	No	No	0	8	7
32	R:R:A39	R:R:F369	5.55	No	Yes	0	8	8
33	R:R:F40	R:R:R47	3.21	Yes	No	2	8	8
34	R:R:F40	R:R:Y52	4.13	Yes	Yes	2	8	6
35	R:R:F40	R:R:L55	19.49	Yes	No	0	8	7
36	R:R:F365	R:R:F40	3.22	Yes	Yes	2	8	8
37	R:R:I372	R:R:V42	6.14	No	No	0	6	6
38	R:R:D43	R:R:N45	4.04	No	No	0	7	6
39	R:R:D43	R:R:L46	12.21	No	Yes	2	7	9
40	R:R:A368	R:R:D43	4.63	No	No	2	8	7
41	R:R:K44	R:R:R47	3.71	No	No	0	7	8
42	R:R:L46	R:R:S51	6.01	Yes	No	2	9	9
43	R:R:F365	R:R:L46	6.09	Yes	Yes	2	8	9
44	R:R:A368	R:R:L46	4.73	No	Yes	2	8	9
45	R:R:R47	R:R:Y52	7.2	No	Yes	2	8	6
46	R:R:H48	R:R:R49	7.9	Yes	Yes	3	7	7
47	R:R:H48	R:R:S50	4.18	Yes	No	0	7	8
48	R:R:H48	R:R:Y122	3.27	Yes	Yes	3	7	8
49	R:R:H48	R:R:R364	7.9	Yes	No	0	7	7
50	R:R:F53	R:R:R49	3.21	Yes	Yes	3	8	7
51	R:R:D111	R:R:R49	10.72	No	Yes	3	9	7
52	R:R:R49	R:R:Y122	7.2	Yes	Yes	3	7	8
53	R:R:H126	R:R:R49	10.16	No	Yes	0	7	7
54	R:R:F365	R:R:S51	5.28	Yes	No	2	8	9
55	R:R:I132	R:R:Y52	6.04	No	Yes	0	7	6
56	R:R:M136	R:R:Y52	3.59	No	Yes	0	8	6
57	R:R:F53	R:R:L107	17.05	Yes	No	0	8	8
58	R:R:D111	R:R:F53	3.58	No	Yes	3	9	8
59	R:R:F53	R:R:L135	3.65	Yes	No	0	8	7
60	R:R:F54	R:R:I108	7.54	Yes	No	0	8	9
61	R:R:F54	R:R:P359	5.78	Yes	No	0	8	8
62	R:R:F54	R:R:H362	6.79	Yes	No	0	8	9
63	R:R:F365	R:R:F54	5.36	Yes	Yes	0	8	8
64	R:R:I59	R:R:L55	7.14	No	No	0	6	7
65	R:R:N104	R:R:N56	13.62	No	No	0	8	9
66	R:R:M136	R:R:N56	8.41	No	No	0	8	9
67	R:R:N56	R:R:W140	10.17	No	Yes	0	9	9
68	R:R:D61	R:R:L57	5.43	Yes	No	0	9	9
69	R:R:A100	R:R:S60	3.42	No	No	5	8	9
70	R:R:S60	R:R:W140	6.18	No	Yes	5	9	9
71	R:R:D61	R:R:S101	5.89	Yes	No	0	9	9
72	R:R:D61	R:R:S351	7.36	Yes	No	0	9	9
73	R:R:D61	R:R:N354	8.08	Yes	No	0	9	9
74	R:R:D61	R:R:P355	4.83	Yes	No	4	9	9
75	R:R:F62	R:R:F63	5.36	No	No	0	8	6
76	R:R:F63	R:R:L97	6.09	No	No	0	6	6
77	R:R:G65	R:R:V64	3.68	No	No	0	8	8
78	R:R:L97	R:R:V64	4.47	No	No	0	6	8
79	R:R:S351	R:R:V64	6.46	No	No	0	9	8
80	R:R:I67	R:R:V66	3.07	No	No	0	6	5
81	R:R:I67	R:R:T93	6.08	No	No	0	6	5
82	R:R:D94	R:R:S68	7.36	No	No	1	8	8
83	R:R:S68	R:R:W348	4.94	No	Yes	1	8	8
84	R:R:I69	R:R:W345	5.87	Yes	Yes	1	8	8
85	R:R:I69	R:R:W348	5.87	Yes	Yes	1	8	8
86	R:R:L71	R:R:W90	3.42	No	No	0	5	7
87	R:R:T76	R:R:Y72	14.98	No	Yes	0	5	7
88	R:R:W90	R:R:Y72	8.68	No	Yes	0	7	7
89	R:R:W345	R:R:Y72	3.86	Yes	Yes	1	8	7
90	R:R:W348	R:R:Y72	7.72	Yes	Yes	1	8	7
91	R:R:I73	R:R:P74	5.08	No	No	0	6	5
92	R:R:F82	R:R:P74	8.67	Yes	No	0	6	5
93	R:R:L77	R:R:T76	5.9	Yes	No	0	6	5
94	R:R:F82	R:R:W80	12.03	Yes	No	0	6	9
95	R:R:F82	R:R:I86	5.02	Yes	No	0	6	5
96	R:R:C164	R:R:C87	7.28	No	No	0	9	9
97	R:R:L152	R:R:V88	2.98	No	No	0	5	7
98	R:R:E155	R:R:V88	12.84	No	No	0	6	7
99	R:R:F89	R:R:T93	6.49	No	No	0	4	5
100	R:R:L91	R:R:P166	4.93	No	Yes	0	6	7
101	R:R:D94	R:R:W348	11.17	No	Yes	1	8	8
102	R:R:N147	R:R:Y95	13.96	Yes	No	0	8	8
103	R:R:P166	R:R:Y95	5.56	Yes	No	0	7	8
104	R:R:L96	R:R:W140	6.83	No	Yes	0	6	9
105	R:R:A143	R:R:T99	3.36	No	No	0	8	8
106	R:R:E182	R:R:T99	4.23	Yes	No	0	8	8
107	R:R:A100	R:R:W140	7.78	No	Yes	5	8	9
108	R:R:P186	R:R:V102	3.53	No	No	0	9	8
109	R:R:F312	R:R:V102	5.24	No	No	1	9	8
110	R:R:V102	R:R:W316	8.58	No	Yes	1	8	9
111	R:R:V146	R:R:Y103	3.79	No	No	0	7	7
112	R:R:N104	R:R:V139	4.43	No	No	0	8	8
113	R:R:I105	R:R:N354	5.66	No	No	0	9	9
114	R:R:I105	R:R:Y358	9.67	No	No	0	9	9
115	R:R:P186	R:R:V106	3.53	No	No	0	9	7
116	R:R:L189	R:R:V106	2.98	No	No	0	7	7
117	R:R:V106	R:R:V190	3.21	No	No	0	7	9
118	R:R:S109	R:R:V190	6.46	No	No	0	9	9
119	R:R:L114	R:R:Y110	15.24	No	No	0	5	6
120	R:R:F193	R:R:Y110	8.25	No	No	0	7	6
121	R:R:D111	R:R:Y122	11.49	No	Yes	3	9	8
122	R:R:N194	R:R:R112	4.82	No	No	6	9	9
123	R:R:L305	R:R:R112	3.64	No	No	6	8	9
124	R:R:L308	R:R:R112	3.64	No	No	0	8	9
125	R:R:S117	R:R:Y113	6.36	No	Yes	0	7	9
126	R:R:F193	R:R:Y113	9.28	No	Yes	0	7	9
127	R:R:N196	R:R:Y113	5.81	No	Yes	0	6	9
128	R:R:I197	R:R:Y113	3.63	No	Yes	0	9	9
129	R:R:S115	R:R:V116	3.23	No	No	0	8	8
130	R:R:S115	R:R:Y122	8.9	No	Yes	0	8	8
131	R:R:I197	R:R:V116	7.68	No	No	0	9	8
132	R:R:L201	R:R:V116	2.98	No	No	0	8	8
133	R:R:N118	R:R:S121	5.96	No	No	0	6	5
134	R:R:Q125	R:R:T124	9.92	No	No	0	5	5
135	R:R:L130	R:R:V133	2.98	No	No	0	5	3
136	R:R:L145	R:R:V141	2.98	No	No	0	4	4
137	R:R:F144	R:R:L145	3.65	Yes	No	0	5	4
138	R:R:F144	R:R:G148	4.52	Yes	No	7	5	5
139	R:R:F144	R:R:P149	4.33	Yes	No	7	5	8
140	R:R:N147	R:R:V146	7.39	Yes	No	0	8	7
141	R:R:I151	R:R:N147	4.25	No	Yes	0	7	8
142	R:R:E182	R:R:N147	5.26	Yes	Yes	0	8	8
143	R:R:G148	R:R:P149	4.06	No	No	7	5	8
144	R:R:I174	R:R:M150	8.75	No	No	0	8	7
145	R:R:I151	R:R:P166	3.39	No	Yes	0	7	7
146	R:R:S156	R:R:V153	3.23	No	No	0	5	5
147	R:R:V153	R:R:W157	4.9	No	No	0	5	6
148	R:R:F168	R:R:S154	7.93	Yes	No	0	6	8
149	R:R:F168	R:R:W157	22.05	Yes	No	0	6	6
150	R:R:G161	R:R:K158	3.49	No	No	0	1	6
151	R:R:G167	R:R:K158	3.49	No	No	0	6	6
152	R:R:E163	R:R:E165	20.3	No	No	0	4	4
153	R:R:F169	R:R:P166	8.67	No	Yes	0	6	7
154	R:R:F168	R:R:S170	7.93	Yes	No	0	6	3
155	R:R:E171	R:R:F168	15.16	No	Yes	8	6	6
156	R:R:F168	R:R:I174	6.28	Yes	No	8	6	8
157	R:R:F169	R:R:L175	8.53	No	No	9	6	7
158	R:R:F169	R:R:T323	7.78	No	No	9	6	7
159	R:R:E171	R:R:Y173	5.61	No	No	0	6	4
160	R:R:E171	R:R:I174	9.56	No	No	8	6	8
161	R:R:W172	R:R:Y173	18.33	No	No	0	4	4
162	R:R:F328	R:R:W172	12.03	No	No	0	5	4
163	R:R:L175	R:R:T323	5.9	No	No	9	7	7
164	R:R:L175	R:R:S327	3	No	No	0	7	6
165	R:R:S179	R:R:S320	6.52	No	No	0	8	8
166	R:R:F180	R:R:L181	4.87	No	No	0	4	5
167	R:R:F180	R:R:V184	6.55	No	No	0	4	7
168	R:R:E182	R:R:W316	3.27	Yes	Yes	1	8	9
169	R:R:F183	R:R:V187	5.24	No	No	0	9	6
170	R:R:I188	R:R:V184	3.07	No	No	0	4	7
171	R:R:I185	R:R:P186	3.39	No	No	0	6	9
172	R:R:L309	R:R:V190	2.98	No	No	0	8	9
173	R:R:A191	R:R:L309	3.15	No	No	0	5	8
174	R:R:F193	R:R:Y192	6.19	No	No	0	7	5
175	R:R:N196	R:R:Y192	16.28	No	No	0	6	5
176	R:R:L305	R:R:N194	8.24	No	No	6	8	9
177	R:R:W199	R:R:Y198	4.82	No	No	0	4	7
178	R:R:A302	R:R:Y198	8.01	No	No	0	7	7
179	R:R:L201	R:R:L301	5.54	No	No	0	8	8
180	R:R:L301	R:R:L305	4.15	No	No	0	8	8
181	R:R:L308	R:R:L357	4.15	No	No	0	8	8
182	R:R:L308	R:R:Y358	7.03	No	No	0	8	9
183	R:R:V311	R:R:V353	3.21	No	No	10	6	7
184	R:R:L357	R:R:V311	4.47	No	No	10	8	6
185	R:R:F312	R:R:W316	8.02	No	Yes	1	9	9
186	R:R:C315	R:R:N350	4.72	No	No	0	8	9
187	R:R:Q347	R:R:W316	17.52	No	Yes	1	8	9
188	R:R:N350	R:R:W316	6.78	No	Yes	0	9	9
189	R:R:A317	R:R:P318	3.74	No	No	0	7	9
190	R:R:Y319	R:R:Y340	8.94	Yes	No	0	7	5
191	R:R:A343	R:R:Y319	4	No	Yes	0	5	7
192	R:R:F344	R:R:Y319	7.22	No	Yes	0	6	7
193	R:R:Q347	R:R:Y319	9.02	No	Yes	0	8	7
194	R:R:F322	R:R:L326	8.53	No	No	0	6	5
195	R:R:V338	R:R:W339	6.13	No	No	0	1	5
196	R:R:F344	R:R:W348	9.02	No	Yes	1	6	8
197	R:R:W345	R:R:W348	12.18	Yes	Yes	1	8	8
198	R:R:F349	R:R:W345	3.01	No	Yes	0	4	8
199	R:R:N350	R:R:N354	12.26	No	No	0	9	9
200	R:R:L357	R:R:V353	4.47	No	No	10	8	7
201	R:R:F369	R:R:L360	4.87	Yes	No	0	8	6
202	R:R:H362	R:R:R364	5.64	No	No	0	9	7
203	R:R:F369	R:R:F373	3.22	Yes	No	0	8	7
204	R:R:C164	R:R:H75	2.95	No	No	0	9	6
205	R:R:I73	R:R:M22	2.92	No	No	0	6	7
206	R:R:N147	R:R:T178	2.92	Yes	No	0	8	8
207	R:R:Q125	R:R:S121	2.89	No	No	0	5	5
208	R:R:A19	R:R:F78	2.77	No	Yes	0	5	5
209	R:R:L31	R:R:L35	2.77	No	No	0	4	8
210	R:R:A317	R:R:F183	2.77	No	No	0	7	9
211	R:R:F78	R:R:V16	2.62	Yes	No	0	5	5
212	R:R:F369	R:R:V36	2.62	Yes	No	0	8	9
213	R:R:F312	R:R:V187	2.62	No	No	0	9	6
214	R:R:F21	R:R:T17	2.59	No	No	0	4	3
215	R:R:F144	R:R:T92	2.59	Yes	No	0	5	6
216	R:R:A298	R:R:W202	2.59	No	No	0	8	6
217	R:R:S337	R:R:Y340	2.54	No	No	0	2	5
218	R:R:S327	R:R:W172	2.47	No	No	0	6	4
219	R:R:F78	R:R:L77	2.44	Yes	Yes	0	5	6
220	R:R:K336	R:R:Y340	2.39	No	No	0	4	5
221	R:R:L142	R:R:Y103	2.34	No	No	0	5	7
222	R:R:M195	R:R:W199	2.33	No	No	0	3	4
223	R:R:F82	R:R:H75	2.26	Yes	No	0	6	6
224	R:R:A313	R:R:G310	1.95	No	No	0	6	6
225	R:R:G167	R:R:S154	1.86	No	No	0	6	8
226	R:R:G128	R:R:T127	1.82	No	No	0	4	8
227	R:R:G128	R:R:K131	1.74	No	No	0	4	7
228	R:R:G32	R:R:L31	1.71	No	No	0	8	4
229	R:R:G310	R:R:L309	1.71	No	No	0	6	8
230	R:R:G148	R:R:N147	1.7	No	Yes	0	5	8
231	R:R:I69	R:R:P70	1.69	Yes	No	0	8	9
232	R:R:D81	R:R:G83	1.68	No	No	0	3	7
233	R:R:L356	R:R:P355	1.64	No	No	0	6	9
234	R:R:A39	R:R:I372	1.62	No	No	0	8	6
235	R:R:A176	R:R:I324	1.62	No	No	0	6	6
236	R:R:A368	R:R:I372	1.62	No	No	0	8	6
237	R:R:V137	R:R:V141	1.6	No	No	0	4	4
238	R:R:T92	R:R:V88	1.59	No	No	0	6	7
239	R:R:C315	R:R:L346	1.59	No	No	0	8	8
240	R:R:A317	R:R:L321	1.58	No	No	0	7	6
241	R:R:E165	R:R:P166	1.57	No	Yes	0	4	7
242	R:R:I324	R:R:S179	1.55	No	No	0	6	8
243	R:R:I37	R:R:V41	1.54	No	No	0	8	3
244	R:R:I307	R:R:V311	1.54	No	No	0	7	6
245	R:R:I324	R:R:T323	1.52	No	No	0	6	7
246	R:R:F82	R:R:G83	1.51	Yes	No	0	6	7
247	R:R:K131	R:R:T134	1.5	No	No	0	7	3
248	R:R:L326	R:R:V325	1.49	No	No	0	5	6
249	R:R:L130	R:R:T134	1.47	No	No	0	5	3
250	R:R:K367	R:R:K371	1.44	No	No	0	5	5
251	R:R:I177	R:R:L181	1.43	No	No	0	5	5
252	R:R:I185	R:R:L181	1.43	No	No	0	6	5
253	R:R:K367	R:R:N45	1.4	No	No	0	5	6
254	R:R:M195	R:R:N194	1.4	No	No	0	3	9
255	R:R:K363	R:R:Q366	1.36	No	No	0	5	9
256	R:R:R300	R:R:S304	1.32	No	No	0	8	8
257	R:R:D81	R:R:E79	1.3	No	No	0	3	3
258	R:R:R123	R:R:T124	1.29	No	No	0	5	5
259	R:R:N118	R:R:Y122	1.16	No	Yes	0	6	8
260	R:R:F322	R:R:W339	1	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.35	8	1	0
2	R:R:F40	7.5125	4	2	8
3	R:R:L46	7.26	4	2	9
4	R:R:H48	5.8125	4	3	7
5	R:R:R49	7.838	5	3	7
6	R:R:Y52	5.24	4	2	6
7	R:R:F53	6.8725	4	3	8
8	R:R:F54	6.3675	4	0	8
9	R:R:D61	6.38667	6	4	9
10	R:R:I69	4.9825	4	1	8
11	R:R:Y72	8.81	4	1	7
12	R:R:L77	4.53	4	0	6
13	R:R:F78	3.56	4	0	5
14	R:R:F82	5.898	5	0	6
15	R:R:Y113	6.27	4	0	9
16	R:R:Y122	6.404	5	3	8
17	R:R:W140	7.74	4	5	9
18	R:R:F144	3.7725	4	7	5
19	R:R:N147	5.91333	6	0	8
20	R:R:P166	4.824	5	0	7
21	R:R:F168	11.87	5	8	6
22	R:R:E182	5.8875	4	1	8
23	R:R:W316	8.59833	6	1	9
24	R:R:Y319	7.295	4	0	7
25	R:R:W345	6.612	5	1	8
26	R:R:W348	8.33143	7	1	8
27	R:R:F365	4.776	5	2	8
28	R:R:F369	3.982	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W348	62.7467	7.42	Yes	Yes	1	0	8
2	R:R:W348	R:R:Y72	20.563	7.72	Yes	Yes	1	8	7
3	R:R:T76	R:R:Y72	16.5041	14.98	No	Yes	0	5	7
4	R:R:L77	R:R:T76	15.022	5.9	Yes	No	0	6	5
5	R:R:F78	R:R:L77	25.1583	2.44	Yes	Yes	0	5	6
6	R:R:F78	R:R:R15	16.087	6.41	Yes	No	0	5	3
7	R:R:L12	R:R:R15	13.2792	9.72	No	No	0	3	3
8	R:R:W345	R:R:W348	37.6555	12.18	Yes	Yes	1	8	8
9	R:R:M22	R:R:W345	34.3785	8.14	No	Yes	0	7	8
10	R:R:L77	R:R:M22	16.303	4.24	Yes	No	0	6	7
11	L:L:?1	R:R:W316	74.4917	7.42	Yes	Yes	1	0	9
12	R:R:N350	R:R:W316	100	6.78	No	Yes	0	9	9
13	R:R:N350	R:R:N354	99.5978	12.26	No	No	0	9	9
14	R:R:I105	R:R:N354	93.029	5.66	No	No	0	9	9
15	R:R:I105	R:R:Y358	92.4778	9.67	No	No	0	9	9
16	R:R:L308	R:R:Y358	91.9044	7.03	No	No	0	8	9
17	R:R:L308	R:R:R112	89.2679	3.64	No	No	0	8	9
18	R:R:L305	R:R:R112	83.4215	3.64	No	No	6	8	9
19	R:R:L301	R:R:L305	85.477	4.15	No	No	0	8	8
20	R:R:L201	R:R:L301	84.695	5.54	No	No	0	8	8
21	R:R:L201	R:R:V116	84.0992	2.98	No	No	0	8	8
22	R:R:S115	R:R:V116	76.2121	3.23	No	No	0	8	8
23	R:R:S115	R:R:Y122	75.3482	8.9	No	Yes	0	8	8
24	R:R:H48	R:R:Y122	58.5462	3.27	Yes	Yes	3	7	8
25	R:R:H48	R:R:R364	58.3749	7.9	Yes	No	0	7	7
26	R:R:H362	R:R:R364	57.511	5.64	No	No	0	9	7
27	R:R:F54	R:R:H362	56.364	6.79	Yes	No	0	8	9
28	R:R:F365	R:R:F54	52.953	5.36	Yes	Yes	0	8	8
29	R:R:F365	R:R:V36	16.0721	3.93	Yes	No	0	8	9
30	R:R:F369	R:R:V36	13.1973	2.62	Yes	No	0	8	9
31	R:R:D61	R:R:N354	32.0176	8.08	Yes	No	0	9	9
32	R:R:D61	R:R:S351	11.5514	7.36	Yes	No	0	9	9
33	R:R:D61	R:R:N33	13.0707	6.73	Yes	No	4	9	9
34	R:R:F62	R:R:N33	11.5811	4.83	No	No	0	8	9
35	R:R:F365	R:R:F40	26.5137	3.22	Yes	Yes	2	8	8
36	R:R:F40	R:R:Y52	15.9008	4.13	Yes	Yes	2	8	6
37	R:R:F365	R:R:L46	13.093	6.09	Yes	Yes	2	8	9
38	R:R:M136	R:R:Y52	13.1228	3.59	No	Yes	0	8	6
39	R:R:M136	R:R:N56	11.7673	8.41	No	No	0	8	9
40	R:R:I73	R:R:M22	18.6043	2.92	No	No	0	6	7
41	R:R:I73	R:R:P74	17.1967	5.08	No	No	0	6	5
42	R:R:F82	R:R:P74	15.5433	8.67	Yes	No	0	6	5
43	L:L:?1	R:R:Y95	47.2704	21	Yes	No	0	0	8
44	R:R:N147	R:R:Y95	10.315	13.96	Yes	No	0	8	8
45	R:R:G148	R:R:N147	23.0133	1.7	No	Yes	0	5	8
46	R:R:F144	R:R:G148	18.2617	4.52	Yes	No	7	5	5
47	R:R:E182	R:R:N147	24.1677	5.26	Yes	Yes	0	8	8
48	R:R:P166	R:R:Y95	42.9731	5.56	Yes	No	0	7	8
49	R:R:V102	R:R:W316	25.3742	8.58	No	Yes	1	8	9
50	R:R:P186	R:R:V102	24.5699	3.53	No	No	0	9	8
51	R:R:P186	R:R:V106	13.5175	3.53	No	No	0	9	7
52	R:R:V106	R:R:V190	10.2257	3.21	No	No	0	7	9
53	R:R:I197	R:R:V116	15.0369	7.68	No	No	0	9	8
54	R:R:I197	R:R:Y113	13.4952	3.63	No	Yes	0	9	9
55	R:R:F169	R:R:P166	40.5303	8.67	No	Yes	0	6	7
56	R:R:F169	R:R:L175	30.0216	8.53	No	No	9	6	7
57	R:R:L175	R:R:S327	28.9566	3	No	No	0	7	6
58	R:R:S327	R:R:W172	27.2436	2.47	No	No	0	6	4
59	R:R:W172	R:R:Y173	23.773	18.33	No	No	0	4	4
60	R:R:E171	R:R:Y173	22.0153	5.61	No	No	0	6	4
61	R:R:E171	R:R:F168	16.7498	15.16	No	Yes	8	6	6
62	R:R:I185	R:R:P186	10.2257	3.39	No	No	0	6	9
63	R:R:E182	R:R:W316	19.1033	3.27	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D94	7.73	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y95	21	1	Yes	No	0	8	0	1
L:L:?1	R:R:C98	10.34	1	Yes	No	0	8	0	1
L:L:?1	R:R:E182	10.79	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W316	7.42	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F344	17.85	1	Yes	No	0	6	0	1
L:L:?1	R:R:Q347	16.25	1	Yes	No	0	8	0	1
L:L:?1	R:R:W348	7.42	1	Yes	Yes	0	8	0	1
R:R:D94	R:R:S68	7.36	1	No	No	8	8	1	2
R:R:S68	R:R:W348	4.94	1	No	Yes	8	8	2	1
R:R:I69	R:R:W345	5.87	1	Yes	Yes	8	8	2	2
R:R:I69	R:R:W348	5.87	1	Yes	Yes	8	8	2	1
R:R:W345	R:R:Y72	3.86	1	Yes	Yes	8	7	2	2
R:R:W348	R:R:Y72	7.72	1	Yes	Yes	8	7	1	2
R:R:D94	R:R:W348	11.17	1	No	Yes	8	8	1	1
R:R:N147	R:R:Y95	13.96	0	Yes	No	8	8	2	1
R:R:P166	R:R:Y95	5.56	0	Yes	No	7	8	2	1
R:R:E182	R:R:T99	4.23	1	Yes	No	8	8	1	2
R:R:F312	R:R:V102	5.24	1	No	No	9	8	2	2
R:R:V102	R:R:W316	8.58	1	No	Yes	8	9	2	1
R:R:E182	R:R:N147	5.26	1	Yes	Yes	8	8	1	2
R:R:E182	R:R:W316	3.27	1	Yes	Yes	8	9	1	1
R:R:F312	R:R:W316	8.02	1	No	Yes	9	9	2	1
R:R:Q347	R:R:W316	17.52	1	No	Yes	8	9	1	1
R:R:N350	R:R:W316	6.78	0	No	Yes	9	9	2	1
R:R:F344	R:R:Y319	7.22	1	No	Yes	6	7	1	2
R:R:Q347	R:R:Y319	9.02	1	No	Yes	8	7	1	2
R:R:F344	R:R:W348	9.02	1	No	Yes	6	8	1	1
R:R:W345	R:R:W348	12.18	1	Yes	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YFD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	239
Number of Links	260
Number of Hubs	28
Number of Links mediated by Hubs	114
Number of Communities	10
Number of Nodes involved in Communities	47
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	27984
Length Of Smallest Path	3
Average Path Length	15.468
Length of Longest Path	38
Minimum Path Strength	1.42
Average Path Strength	6.57025
Maximum Path Strength	19.425
Minimum Path Correlation	0.7
Average Path Correlation	0.919762
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	44.9947
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.9582
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • regulation of intracellular signal transduction • regulation of response to stimulus • MAPK cascade • regulation of cell communication • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ITF
Name	2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate
Synonyms
Identifier
Formula	C6 H10 N4 S
Molecular Weight	170.235
SMILES
PubChem	3692
Formal Charge	0
Total Atoms	21
Total Chiral Atoms	0
Total Bonds	21
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>7YFD_nogp_Chain_R L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D K N L R H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N A V S Y R T Q H T G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K G S E C E P G F F S E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F Q K A F L K I F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ	2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	10.1038/s41589-024-01620-6
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	10.1038/s41467-024-46840-5
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	10.1038/s41467-024-46840-5
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	10.1038/s41467-024-46840-5
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	10.1038/s41467-023-42260-z
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	10.1038/s41467-023-42260-z
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	10.1038/s41422-023-00835-x
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	10.1038/s41467-023-41654-3
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WH4 (Multimeric)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-		3.4	2020-09-23	10.1016/j.cell.2020.08.024

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