psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D94	7.73	Yes	No	1	0	8
2	L:L:?1	R:R:Y95	21	Yes	No	0	0	8
3	L:L:?1	R:R:C98	10.34	Yes	No	0	0	8
4	L:L:?1	R:R:E182	10.79	Yes	Yes	1	0	8
5	L:L:?1	R:R:W316	7.42	Yes	Yes	1	0	9
6	L:L:?1	R:R:F344	17.85	Yes	No	1	0	6
7	L:L:?1	R:R:Q347	16.25	Yes	No	1	0	8
8	L:L:?1	R:R:W348	7.42	Yes	Yes	1	0	8
9	R:R:L12	R:R:T14	4.42	No	No	0	3	5
10	R:R:L12	R:R:R15	9.72	No	No	0	3	3
11	R:R:T14	R:R:T17	3.14	No	No	0	5	3
12	R:R:F78	R:R:R15	6.41	Yes	No	0	5	3
13	R:R:L18	R:R:L77	5.54	No	Yes	0	5	6
14	R:R:F20	R:R:L24	7.31	No	No	0	4	5
15	R:R:L77	R:R:M22	4.24	Yes	No	0	6	7
16	R:R:M22	R:R:W345	8.14	No	Yes	0	7	8
17	R:R:F349	R:R:V25	6.55	No	No	0	4	7
18	R:R:A26	R:R:I69	6.5	No	Yes	0	7	8
19	R:R:F27	R:R:L31	7.31	No	No	0	5	4
20	R:R:A28	R:R:F352	5.55	No	No	0	4	6
21	R:R:G65	R:R:I29	3.53	No	No	0	8	8
22	R:R:F352	R:R:I29	5.02	No	No	0	6	8
23	R:R:F62	R:R:M30	6.22	No	No	0	8	6
24	R:R:M30	R:R:V66	6.09	No	No	0	6	5
25	R:R:D61	R:R:N33	6.73	Yes	No	4	9	9
26	R:R:F62	R:R:N33	4.83	No	No	0	8	9
27	R:R:N33	R:R:P355	6.52	No	No	4	9	9
28	R:R:F369	R:R:L35	3.65	Yes	No	0	8	8
29	R:R:A58	R:R:V36	3.39	No	No	0	9	9
30	R:R:F365	R:R:V36	3.93	Yes	No	0	8	9
31	R:R:I37	R:R:L55	4.28	No	No	0	8	7
32	R:R:A39	R:R:F369	5.55	No	Yes	0	8	8
33	R:R:F40	R:R:R47	3.21	Yes	No	2	8	8
34	R:R:F40	R:R:Y52	4.13	Yes	Yes	2	8	6
35	R:R:F40	R:R:L55	19.49	Yes	No	0	8	7
36	R:R:F365	R:R:F40	3.22	Yes	Yes	2	8	8
37	R:R:I372	R:R:V42	6.14	No	No	0	6	6
38	R:R:D43	R:R:N45	4.04	No	No	0	7	6
39	R:R:D43	R:R:L46	12.21	No	Yes	2	7	9
40	R:R:A368	R:R:D43	4.63	No	No	2	8	7
41	R:R:K44	R:R:R47	3.71	No	No	0	7	8
42	R:R:L46	R:R:S51	6.01	Yes	No	2	9	9
43	R:R:F365	R:R:L46	6.09	Yes	Yes	2	8	9
44	R:R:A368	R:R:L46	4.73	No	Yes	2	8	9
45	R:R:R47	R:R:Y52	7.2	No	Yes	2	8	6
46	R:R:H48	R:R:R49	7.9	Yes	Yes	3	7	7
47	R:R:H48	R:R:S50	4.18	Yes	No	0	7	8
48	R:R:H48	R:R:Y122	3.27	Yes	Yes	3	7	8
49	R:R:H48	R:R:R364	7.9	Yes	No	0	7	7
50	R:R:F53	R:R:R49	3.21	Yes	Yes	3	8	7
51	R:R:D111	R:R:R49	10.72	No	Yes	3	9	7
52	R:R:R49	R:R:Y122	7.2	Yes	Yes	3	7	8
53	R:R:H126	R:R:R49	10.16	No	Yes	0	7	7
54	R:R:F365	R:R:S51	5.28	Yes	No	2	8	9
55	R:R:I132	R:R:Y52	6.04	No	Yes	0	7	6
56	R:R:M136	R:R:Y52	3.59	No	Yes	0	8	6
57	R:R:F53	R:R:L107	17.05	Yes	No	0	8	8
58	R:R:D111	R:R:F53	3.58	No	Yes	3	9	8
59	R:R:F53	R:R:L135	3.65	Yes	No	0	8	7
60	R:R:F54	R:R:I108	7.54	Yes	No	0	8	9
61	R:R:F54	R:R:P359	5.78	Yes	No	0	8	8
62	R:R:F54	R:R:H362	6.79	Yes	No	0	8	9
63	R:R:F365	R:R:F54	5.36	Yes	Yes	0	8	8
64	R:R:I59	R:R:L55	7.14	No	No	0	6	7
65	R:R:N104	R:R:N56	13.62	No	No	0	8	9
66	R:R:M136	R:R:N56	8.41	No	No	0	8	9
67	R:R:N56	R:R:W140	10.17	No	Yes	0	9	9
68	R:R:D61	R:R:L57	5.43	Yes	No	0	9	9
69	R:R:A100	R:R:S60	3.42	No	No	5	8	9
70	R:R:S60	R:R:W140	6.18	No	Yes	5	9	9
71	R:R:D61	R:R:S101	5.89	Yes	No	0	9	9
72	R:R:D61	R:R:S351	7.36	Yes	No	0	9	9
73	R:R:D61	R:R:N354	8.08	Yes	No	0	9	9
74	R:R:D61	R:R:P355	4.83	Yes	No	4	9	9
75	R:R:F62	R:R:F63	5.36	No	No	0	8	6
76	R:R:F63	R:R:L97	6.09	No	No	0	6	6
77	R:R:G65	R:R:V64	3.68	No	No	0	8	8
78	R:R:L97	R:R:V64	4.47	No	No	0	6	8
79	R:R:S351	R:R:V64	6.46	No	No	0	9	8
80	R:R:I67	R:R:V66	3.07	No	No	0	6	5
81	R:R:I67	R:R:T93	6.08	No	No	0	6	5
82	R:R:D94	R:R:S68	7.36	No	No	1	8	8
83	R:R:S68	R:R:W348	4.94	No	Yes	1	8	8
84	R:R:I69	R:R:W345	5.87	Yes	Yes	1	8	8
85	R:R:I69	R:R:W348	5.87	Yes	Yes	1	8	8
86	R:R:L71	R:R:W90	3.42	No	No	0	5	7
87	R:R:T76	R:R:Y72	14.98	No	Yes	0	5	7
88	R:R:W90	R:R:Y72	8.68	No	Yes	0	7	7
89	R:R:W345	R:R:Y72	3.86	Yes	Yes	1	8	7
90	R:R:W348	R:R:Y72	7.72	Yes	Yes	1	8	7
91	R:R:I73	R:R:P74	5.08	No	No	0	6	5
92	R:R:F82	R:R:P74	8.67	Yes	No	0	6	5
93	R:R:L77	R:R:T76	5.9	Yes	No	0	6	5
94	R:R:F82	R:R:W80	12.03	Yes	No	0	6	9
95	R:R:F82	R:R:I86	5.02	Yes	No	0	6	5
96	R:R:C164	R:R:C87	7.28	No	No	0	9	9
97	R:R:L152	R:R:V88	2.98	No	No	0	5	7
98	R:R:E155	R:R:V88	12.84	No	No	0	6	7
99	R:R:F89	R:R:T93	6.49	No	No	0	4	5
100	R:R:L91	R:R:P166	4.93	No	Yes	0	6	7
101	R:R:D94	R:R:W348	11.17	No	Yes	1	8	8
102	R:R:N147	R:R:Y95	13.96	Yes	No	0	8	8
103	R:R:P166	R:R:Y95	5.56	Yes	No	0	7	8
104	R:R:L96	R:R:W140	6.83	No	Yes	0	6	9
105	R:R:A143	R:R:T99	3.36	No	No	0	8	8
106	R:R:E182	R:R:T99	4.23	Yes	No	0	8	8
107	R:R:A100	R:R:W140	7.78	No	Yes	5	8	9
108	R:R:P186	R:R:V102	3.53	No	No	0	9	8
109	R:R:F312	R:R:V102	5.24	No	No	1	9	8
110	R:R:V102	R:R:W316	8.58	No	Yes	1	8	9
111	R:R:V146	R:R:Y103	3.79	No	No	0	7	7
112	R:R:N104	R:R:V139	4.43	No	No	0	8	8
113	R:R:I105	R:R:N354	5.66	No	No	0	9	9
114	R:R:I105	R:R:Y358	9.67	No	No	0	9	9
115	R:R:P186	R:R:V106	3.53	No	No	0	9	7
116	R:R:L189	R:R:V106	2.98	No	No	0	7	7
117	R:R:V106	R:R:V190	3.21	No	No	0	7	9
118	R:R:S109	R:R:V190	6.46	No	No	0	9	9
119	R:R:L114	R:R:Y110	15.24	No	No	0	5	6
120	R:R:F193	R:R:Y110	8.25	No	No	0	7	6
121	R:R:D111	R:R:Y122	11.49	No	Yes	3	9	8
122	R:R:N194	R:R:R112	4.82	No	No	6	9	9
123	R:R:L305	R:R:R112	3.64	No	No	6	8	9
124	R:R:L308	R:R:R112	3.64	No	No	0	8	9
125	R:R:S117	R:R:Y113	6.36	No	Yes	0	7	9
126	R:R:F193	R:R:Y113	9.28	No	Yes	0	7	9
127	R:R:N196	R:R:Y113	5.81	No	Yes	0	6	9
128	R:R:I197	R:R:Y113	3.63	No	Yes	0	9	9
129	R:R:S115	R:R:V116	3.23	No	No	0	8	8
130	R:R:S115	R:R:Y122	8.9	No	Yes	0	8	8
131	R:R:I197	R:R:V116	7.68	No	No	0	9	8
132	R:R:L201	R:R:V116	2.98	No	No	0	8	8
133	R:R:N118	R:R:S121	5.96	No	No	0	6	5
134	R:R:Q125	R:R:T124	9.92	No	No	0	5	5
135	R:R:L130	R:R:V133	2.98	No	No	0	5	3
136	R:R:L145	R:R:V141	2.98	No	No	0	4	4
137	R:R:F144	R:R:L145	3.65	Yes	No	0	5	4
138	R:R:F144	R:R:G148	4.52	Yes	No	7	5	5
139	R:R:F144	R:R:P149	4.33	Yes	No	7	5	8
140	R:R:N147	R:R:V146	7.39	Yes	No	0	8	7
141	R:R:I151	R:R:N147	4.25	No	Yes	0	7	8
142	R:R:E182	R:R:N147	5.26	Yes	Yes	0	8	8
143	R:R:G148	R:R:P149	4.06	No	No	7	5	8
144	R:R:I174	R:R:M150	8.75	No	No	0	8	7
145	R:R:I151	R:R:P166	3.39	No	Yes	0	7	7
146	R:R:S156	R:R:V153	3.23	No	No	0	5	5
147	R:R:V153	R:R:W157	4.9	No	No	0	5	6
148	R:R:F168	R:R:S154	7.93	Yes	No	0	6	8
149	R:R:F168	R:R:W157	22.05	Yes	No	0	6	6
150	R:R:G161	R:R:K158	3.49	No	No	0	1	6
151	R:R:G167	R:R:K158	3.49	No	No	0	6	6
152	R:R:E163	R:R:E165	20.3	No	No	0	4	4
153	R:R:F169	R:R:P166	8.67	No	Yes	0	6	7
154	R:R:F168	R:R:S170	7.93	Yes	No	0	6	3
155	R:R:E171	R:R:F168	15.16	No	Yes	8	6	6
156	R:R:F168	R:R:I174	6.28	Yes	No	8	6	8
157	R:R:F169	R:R:L175	8.53	No	No	9	6	7
158	R:R:F169	R:R:T323	7.78	No	No	9	6	7
159	R:R:E171	R:R:Y173	5.61	No	No	0	6	4
160	R:R:E171	R:R:I174	9.56	No	No	8	6	8
161	R:R:W172	R:R:Y173	18.33	No	No	0	4	4
162	R:R:F328	R:R:W172	12.03	No	No	0	5	4
163	R:R:L175	R:R:T323	5.9	No	No	9	7	7
164	R:R:L175	R:R:S327	3	No	No	0	7	6
165	R:R:S179	R:R:S320	6.52	No	No	0	8	8
166	R:R:F180	R:R:L181	4.87	No	No	0	4	5
167	R:R:F180	R:R:V184	6.55	No	No	0	4	7
168	R:R:E182	R:R:W316	3.27	Yes	Yes	1	8	9
169	R:R:F183	R:R:V187	5.24	No	No	0	9	6
170	R:R:I188	R:R:V184	3.07	No	No	0	4	7
171	R:R:I185	R:R:P186	3.39	No	No	0	6	9
172	R:R:L309	R:R:V190	2.98	No	No	0	8	9
173	R:R:A191	R:R:L309	3.15	No	No	0	5	8
174	R:R:F193	R:R:Y192	6.19	No	No	0	7	5
175	R:R:N196	R:R:Y192	16.28	No	No	0	6	5
176	R:R:L305	R:R:N194	8.24	No	No	6	8	9
177	R:R:W199	R:R:Y198	4.82	No	No	0	4	7
178	R:R:A302	R:R:Y198	8.01	No	No	0	7	7
179	R:R:L201	R:R:L301	5.54	No	No	0	8	8
180	R:R:L301	R:R:L305	4.15	No	No	0	8	8
181	R:R:L308	R:R:L357	4.15	No	No	0	8	8
182	R:R:L308	R:R:Y358	7.03	No	No	0	8	9
183	R:R:V311	R:R:V353	3.21	No	No	10	6	7
184	R:R:L357	R:R:V311	4.47	No	No	10	8	6
185	R:R:F312	R:R:W316	8.02	No	Yes	1	9	9
186	R:R:C315	R:R:N350	4.72	No	No	0	8	9
187	R:R:Q347	R:R:W316	17.52	No	Yes	1	8	9
188	R:R:N350	R:R:W316	6.78	No	Yes	0	9	9
189	R:R:A317	R:R:P318	3.74	No	No	0	7	9
190	R:R:Y319	R:R:Y340	8.94	Yes	No	0	7	5
191	R:R:A343	R:R:Y319	4	No	Yes	0	5	7
192	R:R:F344	R:R:Y319	7.22	No	Yes	0	6	7
193	R:R:Q347	R:R:Y319	9.02	No	Yes	0	8	7
194	R:R:F322	R:R:L326	8.53	No	No	0	6	5
195	R:R:V338	R:R:W339	6.13	No	No	0	1	5
196	R:R:F344	R:R:W348	9.02	No	Yes	1	6	8
197	R:R:W345	R:R:W348	12.18	Yes	Yes	1	8	8
198	R:R:F349	R:R:W345	3.01	No	Yes	0	4	8
199	R:R:N350	R:R:N354	12.26	No	No	0	9	9
200	R:R:L357	R:R:V353	4.47	No	No	10	8	7
201	R:R:F369	R:R:L360	4.87	Yes	No	0	8	6
202	R:R:H362	R:R:R364	5.64	No	No	0	9	7
203	R:R:F369	R:R:F373	3.22	Yes	No	0	8	7
204	R:R:C164	R:R:H75	2.95	No	No	0	9	6
205	R:R:I73	R:R:M22	2.92	No	No	0	6	7
206	R:R:N147	R:R:T178	2.92	Yes	No	0	8	8
207	R:R:Q125	R:R:S121	2.89	No	No	0	5	5
208	R:R:A19	R:R:F78	2.77	No	Yes	0	5	5
209	R:R:L31	R:R:L35	2.77	No	No	0	4	8
210	R:R:A317	R:R:F183	2.77	No	No	0	7	9
211	R:R:F78	R:R:V16	2.62	Yes	No	0	5	5
212	R:R:F369	R:R:V36	2.62	Yes	No	0	8	9
213	R:R:F312	R:R:V187	2.62	No	No	0	9	6
214	R:R:F21	R:R:T17	2.59	No	No	0	4	3
215	R:R:F144	R:R:T92	2.59	Yes	No	0	5	6
216	R:R:A298	R:R:W202	2.59	No	No	0	8	6
217	R:R:S337	R:R:Y340	2.54	No	No	0	2	5
218	R:R:S327	R:R:W172	2.47	No	No	0	6	4
219	R:R:F78	R:R:L77	2.44	Yes	Yes	0	5	6
220	R:R:K336	R:R:Y340	2.39	No	No	0	4	5
221	R:R:L142	R:R:Y103	2.34	No	No	0	5	7
222	R:R:M195	R:R:W199	2.33	No	No	0	3	4
223	R:R:F82	R:R:H75	2.26	Yes	No	0	6	6
224	R:R:A313	R:R:G310	1.95	No	No	0	6	6
225	R:R:G167	R:R:S154	1.86	No	No	0	6	8
226	R:R:G128	R:R:T127	1.82	No	No	0	4	8
227	R:R:G128	R:R:K131	1.74	No	No	0	4	7
228	R:R:G32	R:R:L31	1.71	No	No	0	8	4
229	R:R:G310	R:R:L309	1.71	No	No	0	6	8
230	R:R:G148	R:R:N147	1.7	No	Yes	0	5	8
231	R:R:I69	R:R:P70	1.69	Yes	No	0	8	9
232	R:R:D81	R:R:G83	1.68	No	No	0	3	7
233	R:R:L356	R:R:P355	1.64	No	No	0	6	9
234	R:R:A39	R:R:I372	1.62	No	No	0	8	6
235	R:R:A176	R:R:I324	1.62	No	No	0	6	6
236	R:R:A368	R:R:I372	1.62	No	No	0	8	6
237	R:R:V137	R:R:V141	1.6	No	No	0	4	4
238	R:R:T92	R:R:V88	1.59	No	No	0	6	7
239	R:R:C315	R:R:L346	1.59	No	No	0	8	8
240	R:R:A317	R:R:L321	1.58	No	No	0	7	6
241	R:R:E165	R:R:P166	1.57	No	Yes	0	4	7
242	R:R:I324	R:R:S179	1.55	No	No	0	6	8
243	R:R:I37	R:R:V41	1.54	No	No	0	8	3
244	R:R:I307	R:R:V311	1.54	No	No	0	7	6
245	R:R:I324	R:R:T323	1.52	No	No	0	6	7
246	R:R:F82	R:R:G83	1.51	Yes	No	0	6	7
247	R:R:K131	R:R:T134	1.5	No	No	0	7	3
248	R:R:L326	R:R:V325	1.49	No	No	0	5	6
249	R:R:L130	R:R:T134	1.47	No	No	0	5	3
250	R:R:K367	R:R:K371	1.44	No	No	0	5	5
251	R:R:I177	R:R:L181	1.43	No	No	0	5	5
252	R:R:I185	R:R:L181	1.43	No	No	0	6	5
253	R:R:K367	R:R:N45	1.4	No	No	0	5	6
254	R:R:M195	R:R:N194	1.4	No	No	0	3	9
255	R:R:K363	R:R:Q366	1.36	No	No	0	5	9
256	R:R:R300	R:R:S304	1.32	No	No	0	8	8
257	R:R:D81	R:R:E79	1.3	No	No	0	3	3
258	R:R:R123	R:R:T124	1.29	No	No	0	5	5
259	R:R:N118	R:R:Y122	1.16	No	Yes	0	6	8
260	R:R:F322	R:R:W339	1	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.35	8	1	0
2	R:R:F40	7.5125	4	2	8
3	R:R:L46	7.26	4	2	9
4	R:R:H48	5.8125	4	3	7
5	R:R:R49	7.838	5	3	7
6	R:R:Y52	5.24	4	2	6
7	R:R:F53	6.8725	4	3	8
8	R:R:F54	6.3675	4	0	8
9	R:R:D61	6.38667	6	4	9
10	R:R:I69	4.9825	4	1	8
11	R:R:Y72	8.81	4	1	7
12	R:R:L77	4.53	4	0	6
13	R:R:F78	3.56	4	0	5
14	R:R:F82	5.898	5	0	6
15	R:R:Y113	6.27	4	0	9
16	R:R:Y122	6.404	5	3	8
17	R:R:W140	7.74	4	5	9
18	R:R:F144	3.7725	4	7	5
19	R:R:N147	5.91333	6	0	8
20	R:R:P166	4.824	5	0	7
21	R:R:F168	11.87	5	8	6
22	R:R:E182	5.8875	4	1	8
23	R:R:W316	8.59833	6	1	9
24	R:R:Y319	7.295	4	0	7
25	R:R:W345	6.612	5	1	8
26	R:R:W348	8.33143	7	1	8
27	R:R:F365	4.776	5	2	8
28	R:R:F369	3.982	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W348	62.7467	7.42	Yes	Yes	1	0	8
2	R:R:W348	R:R:Y72	20.563	7.72	Yes	Yes	1	8	7
3	R:R:T76	R:R:Y72	16.5041	14.98	No	Yes	0	5	7
4	R:R:L77	R:R:T76	15.022	5.9	Yes	No	0	6	5
5	R:R:F78	R:R:L77	25.1583	2.44	Yes	Yes	0	5	6
6	R:R:F78	R:R:R15	16.087	6.41	Yes	No	0	5	3
7	R:R:L12	R:R:R15	13.2792	9.72	No	No	0	3	3
8	R:R:W345	R:R:W348	37.6555	12.18	Yes	Yes	1	8	8
9	R:R:M22	R:R:W345	34.3785	8.14	No	Yes	0	7	8
10	R:R:L77	R:R:M22	16.303	4.24	Yes	No	0	6	7
11	L:L:?1	R:R:W316	74.4917	7.42	Yes	Yes	1	0	9
12	R:R:N350	R:R:W316	100	6.78	No	Yes	0	9	9
13	R:R:N350	R:R:N354	99.5978	12.26	No	No	0	9	9
14	R:R:I105	R:R:N354	93.029	5.66	No	No	0	9	9
15	R:R:I105	R:R:Y358	92.4778	9.67	No	No	0	9	9
16	R:R:L308	R:R:Y358	91.9044	7.03	No	No	0	8	9
17	R:R:L308	R:R:R112	89.2679	3.64	No	No	0	8	9
18	R:R:L305	R:R:R112	83.4215	3.64	No	No	6	8	9
19	R:R:L301	R:R:L305	85.477	4.15	No	No	0	8	8
20	R:R:L201	R:R:L301	84.695	5.54	No	No	0	8	8
21	R:R:L201	R:R:V116	84.0992	2.98	No	No	0	8	8
22	R:R:S115	R:R:V116	76.2121	3.23	No	No	0	8	8
23	R:R:S115	R:R:Y122	75.3482	8.9	No	Yes	0	8	8
24	R:R:H48	R:R:Y122	58.5462	3.27	Yes	Yes	3	7	8
25	R:R:H48	R:R:R364	58.3749	7.9	Yes	No	0	7	7
26	R:R:H362	R:R:R364	57.511	5.64	No	No	0	9	7
27	R:R:F54	R:R:H362	56.364	6.79	Yes	No	0	8	9
28	R:R:F365	R:R:F54	52.953	5.36	Yes	Yes	0	8	8
29	R:R:F365	R:R:V36	16.0721	3.93	Yes	No	0	8	9
30	R:R:F369	R:R:V36	13.1973	2.62	Yes	No	0	8	9
31	R:R:D61	R:R:N354	32.0176	8.08	Yes	No	0	9	9
32	R:R:D61	R:R:S351	11.5514	7.36	Yes	No	0	9	9
33	R:R:D61	R:R:N33	13.0707	6.73	Yes	No	4	9	9
34	R:R:F62	R:R:N33	11.5811	4.83	No	No	0	8	9
35	R:R:F365	R:R:F40	26.5137	3.22	Yes	Yes	2	8	8
36	R:R:F40	R:R:Y52	15.9008	4.13	Yes	Yes	2	8	6
37	R:R:F365	R:R:L46	13.093	6.09	Yes	Yes	2	8	9
38	R:R:M136	R:R:Y52	13.1228	3.59	No	Yes	0	8	6
39	R:R:M136	R:R:N56	11.7673	8.41	No	No	0	8	9
40	R:R:I73	R:R:M22	18.6043	2.92	No	No	0	6	7
41	R:R:I73	R:R:P74	17.1967	5.08	No	No	0	6	5
42	R:R:F82	R:R:P74	15.5433	8.67	Yes	No	0	6	5
43	L:L:?1	R:R:Y95	47.2704	21	Yes	No	0	0	8
44	R:R:N147	R:R:Y95	10.315	13.96	Yes	No	0	8	8
45	R:R:G148	R:R:N147	23.0133	1.7	No	Yes	0	5	8
46	R:R:F144	R:R:G148	18.2617	4.52	Yes	No	7	5	5
47	R:R:E182	R:R:N147	24.1677	5.26	Yes	Yes	0	8	8
48	R:R:P166	R:R:Y95	42.9731	5.56	Yes	No	0	7	8
49	R:R:V102	R:R:W316	25.3742	8.58	No	Yes	1	8	9
50	R:R:P186	R:R:V102	24.5699	3.53	No	No	0	9	8
51	R:R:P186	R:R:V106	13.5175	3.53	No	No	0	9	7
52	R:R:V106	R:R:V190	10.2257	3.21	No	No	0	7	9
53	R:R:I197	R:R:V116	15.0369	7.68	No	No	0	9	8
54	R:R:I197	R:R:Y113	13.4952	3.63	No	Yes	0	9	9
55	R:R:F169	R:R:P166	40.5303	8.67	No	Yes	0	6	7
56	R:R:F169	R:R:L175	30.0216	8.53	No	No	9	6	7
57	R:R:L175	R:R:S327	28.9566	3	No	No	0	7	6
58	R:R:S327	R:R:W172	27.2436	2.47	No	No	0	6	4
59	R:R:W172	R:R:Y173	23.773	18.33	No	No	0	4	4
60	R:R:E171	R:R:Y173	22.0153	5.61	No	No	0	6	4
61	R:R:E171	R:R:F168	16.7498	15.16	No	Yes	8	6	6
62	R:R:I185	R:R:P186	10.2257	3.39	No	No	0	6	9
63	R:R:E182	R:R:W316	19.1033	3.27	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D94	7.73	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y95	21	1	Yes	No	0	8	0	1
L:L:?1	R:R:C98	10.34	1	Yes	No	0	8	0	1
L:L:?1	R:R:E182	10.79	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W316	7.42	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F344	17.85	1	Yes	No	0	6	0	1
L:L:?1	R:R:Q347	16.25	1	Yes	No	0	8	0	1
L:L:?1	R:R:W348	7.42	1	Yes	Yes	0	8	0	1
R:R:D94	R:R:S68	7.36	1	No	No	8	8	1	2
R:R:S68	R:R:W348	4.94	1	No	Yes	8	8	2	1
R:R:I69	R:R:W345	5.87	1	Yes	Yes	8	8	2	2
R:R:I69	R:R:W348	5.87	1	Yes	Yes	8	8	2	1
R:R:W345	R:R:Y72	3.86	1	Yes	Yes	8	7	2	2
R:R:W348	R:R:Y72	7.72	1	Yes	Yes	8	7	1	2
R:R:D94	R:R:W348	11.17	1	No	Yes	8	8	1	1
R:R:N147	R:R:Y95	13.96	0	Yes	No	8	8	2	1
R:R:P166	R:R:Y95	5.56	0	Yes	No	7	8	2	1
R:R:E182	R:R:T99	4.23	1	Yes	No	8	8	1	2
R:R:F312	R:R:V102	5.24	1	No	No	9	8	2	2
R:R:V102	R:R:W316	8.58	1	No	Yes	8	9	2	1
R:R:E182	R:R:N147	5.26	1	Yes	Yes	8	8	1	2
R:R:E182	R:R:W316	3.27	1	Yes	Yes	8	9	1	1
R:R:F312	R:R:W316	8.02	1	No	Yes	9	9	2	1
R:R:Q347	R:R:W316	17.52	1	No	Yes	8	9	1	1
R:R:N350	R:R:W316	6.78	0	No	Yes	9	9	2	1
R:R:F344	R:R:Y319	7.22	1	No	Yes	6	7	1	2
R:R:Q347	R:R:Y319	9.02	1	No	Yes	8	7	1	2
R:R:F344	R:R:W348	9.02	1	No	Yes	6	8	1	1
R:R:W345	R:R:W348	12.18	1	Yes	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YFD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	239
Number of Links	260
Number of Hubs	28
Number of Links mediated by Hubs	114
Number of Communities	10
Number of Nodes involved in Communities	47
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	27984
Length Of Smallest Path	3
Average Path Length	15.468
Length of Longest Path	38
Minimum Path Strength	1.42
Average Path Strength	6.57025
Maximum Path Strength	19.425
Minimum Path Correlation	0.7
Average Path Correlation	0.919804
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	44.9947
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.9582
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ITF
Name	2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate
Synonyms
Identifier
Formula	C6 H10 N4 S
Molecular Weight	170.235
SMILES
PubChem	3692
Formal Charge	0
Total Atoms	21
Total Chiral Atoms	0
Total Bonds	21
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>7YFD_nogp_Chain_R L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D K N L R H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N A V S Y R T Q H T G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K G S E C E P G F F S E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F Q K A F L K I F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	9JED	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	2.58	2025-09-10	doi.org/10.1038/s41401-025-01633-4
	9JED (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		2.58	2025-09-10	doi.org/10.1038/s41401-025-01633-4
	9L42	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.9	2025-10-22	doi.org/10.3390/ph18030292
	9L42 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.9	2025-10-22	doi.org/10.3390/ph18030292
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	9LRC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	-	2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9LRE	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9LRE (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9JG1	A	Amine	Histamine	H₄	Homo sapiens	Adriforant	-	-	3.62	2025-12-03	10.1038/s41401-025-01633-4
	9JG1 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Adriforant	-		3.62	2025-12-03	10.1038/s41401-025-01633-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7YFD_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.