psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L12	R:R:R15	6.07	No	No	0	3	3
2	R:R:L77	R:R:R15	8.5	Yes	No	0	6	3
3	R:R:I73	R:R:M22	4.37	No	No	0	6	7
4	R:R:A26	R:R:I69	4.87	No	Yes	0	7	8
5	R:R:A28	R:R:F352	5.55	No	No	0	4	6
6	R:R:F352	R:R:I29	3.77	No	No	0	6	8
7	R:R:M30	R:R:V66	4.56	No	No	0	6	5
8	R:R:L31	R:R:L35	5.54	No	No	0	4	8
9	R:R:D61	R:R:N33	8.08	Yes	Yes	0	9	9
10	R:R:F62	R:R:N33	6.04	No	Yes	0	8	9
11	R:R:N33	R:R:P355	3.26	Yes	No	0	9	9
12	R:R:F373	R:R:L35	4.87	No	No	0	7	8
13	R:R:A58	R:R:V36	3.39	No	No	0	9	9
14	R:R:P359	R:R:V36	7.07	No	No	0	8	9
15	R:R:A39	R:R:F369	4.16	No	Yes	0	8	8
16	R:R:F40	R:R:R47	9.62	No	No	0	8	8
17	R:R:F40	R:R:Y52	4.13	No	No	0	8	6
18	R:R:F40	R:R:L55	18.27	No	No	0	8	7
19	R:R:D43	R:R:N45	4.04	Yes	No	0	7	6
20	R:R:D43	R:R:L46	9.5	Yes	No	0	7	9
21	R:R:H48	R:R:R49	5.64	No	Yes	0	7	7
22	R:R:H48	R:R:S50	4.18	No	No	0	7	8
23	R:R:F53	R:R:R49	8.55	Yes	Yes	2	8	7
24	R:R:D111	R:R:R49	7.15	No	Yes	2	9	7
25	R:R:H126	R:R:R49	10.16	No	Yes	0	7	7
26	R:R:I132	R:R:R49	5.01	No	Yes	2	7	7
27	R:R:H362	R:R:S50	11.16	No	No	0	9	8
28	R:R:F365	R:R:S51	5.28	No	No	0	8	9
29	R:R:I132	R:R:Y52	3.63	No	No	0	7	6
30	R:R:M136	R:R:Y52	7.18	No	No	0	8	6
31	R:R:F53	R:R:L107	8.53	Yes	No	0	8	8
32	R:R:D111	R:R:F53	5.97	No	Yes	2	9	8
33	R:R:F53	R:R:I132	3.77	Yes	No	2	8	7
34	R:R:F54	R:R:I108	8.79	Yes	No	4	8	9
35	R:R:F54	R:R:Y358	5.16	Yes	Yes	4	8	9
36	R:R:F54	R:R:H362	11.31	Yes	No	0	8	9
37	R:R:F365	R:R:F54	8.57	No	Yes	0	8	8
38	R:R:I59	R:R:L55	5.71	No	No	0	6	7
39	R:R:N104	R:R:N56	13.62	No	No	0	8	9
40	R:R:M136	R:R:N56	14.02	No	No	0	8	9
41	R:R:N56	R:R:W140	9.04	No	No	0	9	9
42	R:R:L57	R:R:N354	5.49	No	Yes	0	9	9
43	R:R:L57	R:R:Y358	3.52	No	Yes	0	9	9
44	R:R:D61	R:R:S60	4.42	Yes	No	3	9	9
45	R:R:S101	R:R:S60	4.89	No	No	3	9	9
46	R:R:D61	R:R:S101	4.42	Yes	No	3	9	9
47	R:R:D61	R:R:S351	7.36	Yes	No	0	9	9
48	R:R:D61	R:R:N354	8.08	Yes	Yes	0	9	9
49	R:R:F62	R:R:F63	5.36	No	No	0	8	6
50	R:R:F62	R:R:V66	6.55	No	No	0	8	5
51	R:R:F63	R:R:L97	3.65	No	No	0	6	6
52	R:R:S68	R:R:V64	3.23	Yes	Yes	0	8	8
53	R:R:L97	R:R:V64	5.96	No	Yes	0	6	8
54	R:R:S351	R:R:V64	3.23	No	Yes	0	9	8
55	R:R:I67	R:R:T93	9.12	No	No	0	6	5
56	R:R:S68	R:R:W90	3.71	Yes	Yes	1	8	7
57	R:R:D94	R:R:S68	5.89	No	Yes	1	8	8
58	R:R:S68	R:R:W348	7.41	Yes	Yes	1	8	8
59	R:R:I69	R:R:P70	3.39	Yes	No	0	8	9
60	R:R:I69	R:R:W348	7.05	Yes	Yes	0	8	8
61	R:R:L71	R:R:W90	4.56	No	Yes	0	5	7
62	R:R:T76	R:R:Y72	13.73	No	Yes	0	5	7
63	R:R:W90	R:R:Y72	7.72	Yes	Yes	1	7	7
64	R:R:W348	R:R:Y72	13.5	Yes	Yes	1	8	7
65	R:R:I73	R:R:P74	3.39	No	No	0	6	5
66	R:R:P74	R:R:W80	9.46	No	No	5	5	9
67	R:R:F82	R:R:P74	7.22	Yes	No	5	6	5
68	R:R:F82	R:R:H75	18.1	Yes	No	0	6	6
69	R:R:C164	R:R:H75	7.37	No	No	0	9	6
70	R:R:L77	R:R:T76	4.42	Yes	No	0	6	5
71	R:R:F78	R:R:W80	7.02	No	No	0	5	9
72	R:R:F82	R:R:W80	15.03	Yes	No	5	6	9
73	R:R:F82	R:R:I86	5.02	Yes	No	0	6	5
74	R:R:K158	R:R:K84	11.49	No	No	0	6	3
75	R:R:C164	R:R:C87	7.28	No	No	0	9	9
76	R:R:E155	R:R:V88	8.56	No	Yes	0	6	7
77	R:R:F89	R:R:T93	7.78	No	No	0	4	5
78	R:R:W348	R:R:W90	3.75	Yes	Yes	1	8	7
79	R:R:I151	R:R:L91	4.28	Yes	No	1	7	6
80	R:R:C164	R:R:L91	4.76	No	No	0	9	6
81	R:R:L91	R:R:P166	3.28	No	Yes	1	6	7
82	R:R:D94	R:R:W348	3.35	No	Yes	1	8	8
83	L:L:?1	R:R:D94	11.5	Yes	No	1	0	8
84	R:R:N147	R:R:Y95	11.63	No	No	0	8	8
85	R:R:P166	R:R:Y95	5.56	Yes	No	0	7	8
86	L:L:?1	R:R:Y95	32	Yes	No	0	0	8
87	R:R:L96	R:R:W140	5.69	No	No	0	6	9
88	L:L:?1	R:R:C98	5.97	Yes	No	0	0	8
89	R:R:A143	R:R:T99	3.36	No	No	0	8	8
90	R:R:E182	R:R:T99	4.23	No	No	0	8	8
91	R:R:A100	R:R:W140	7.78	No	No	0	8	9
92	R:R:V102	R:R:Y103	3.79	Yes	No	0	8	7
93	R:R:P186	R:R:V102	3.53	No	Yes	0	9	8
94	R:R:F312	R:R:V102	5.24	No	Yes	1	9	8
95	R:R:V102	R:R:W316	7.36	Yes	Yes	1	8	9
96	R:R:V146	R:R:Y103	5.05	No	No	0	7	7
97	R:R:I105	R:R:N354	5.66	No	Yes	0	9	9
98	R:R:I105	R:R:Y358	8.46	No	Yes	0	9	9
99	R:R:I108	R:R:Y358	6.04	No	Yes	4	9	9
100	R:R:S109	R:R:V190	4.85	No	No	0	9	9
101	R:R:L114	R:R:Y110	11.72	No	No	0	5	6
102	R:R:F193	R:R:Y110	10.32	No	No	0	7	6
103	R:R:D111	R:R:Y122	8.05	No	No	0	9	8
104	R:R:S117	R:R:Y113	7.63	No	Yes	0	7	9
105	R:R:F193	R:R:Y113	11.35	No	Yes	0	7	9
106	R:R:N196	R:R:Y113	8.14	No	Yes	0	6	9
107	R:R:I197	R:R:Y113	3.63	Yes	Yes	0	9	9
108	R:R:S115	R:R:V116	3.23	No	No	0	8	8
109	R:R:S115	R:R:Y122	8.9	No	No	0	8	8
110	R:R:I197	R:R:V116	10.75	Yes	No	0	9	8
111	R:R:N118	R:R:S117	4.47	No	No	0	6	7
112	R:R:F144	R:R:G148	4.52	No	No	0	5	5
113	R:R:N147	R:R:V146	10.35	No	No	0	8	7
114	R:R:N147	R:R:T178	5.85	No	No	0	8	8
115	R:R:G148	R:R:P149	4.06	No	No	0	5	8
116	R:R:F168	R:R:M150	12.44	Yes	No	0	6	7
117	R:R:I151	R:R:P166	3.39	Yes	Yes	1	7	7
118	R:R:S154	R:R:W157	6.18	No	No	0	8	6
119	R:R:F168	R:R:S154	6.61	Yes	No	0	6	8
120	R:R:E163	R:R:E165	7.61	No	No	0	4	4
121	R:R:E165	R:R:F169	5.83	No	Yes	0	4	6
122	R:R:F168	R:R:P166	10.11	Yes	Yes	1	6	7
123	R:R:F169	R:R:P166	7.22	Yes	Yes	1	6	7
124	R:R:F168	R:R:F169	5.36	Yes	Yes	1	6	6
125	R:R:F168	R:R:I174	3.77	Yes	No	1	6	8
126	R:R:F168	R:R:L175	4.87	Yes	Yes	1	6	7
127	R:R:F169	R:R:L175	9.74	Yes	Yes	1	6	7
128	R:R:F169	R:R:T323	6.49	Yes	Yes	1	6	7
129	R:R:E171	R:R:Y173	11.22	No	No	1	6	4
130	R:R:E171	R:R:I174	9.56	No	No	1	6	8
131	R:R:I324	R:R:W172	12.92	No	No	0	6	4
132	R:R:S327	R:R:W172	4.94	No	No	0	6	4
133	R:R:F328	R:R:W172	6.01	No	No	0	5	4
134	R:R:I174	R:R:Y173	8.46	No	No	1	8	4
135	R:R:L175	R:R:T323	4.42	Yes	Yes	1	7	7
136	R:R:S179	R:R:S320	3.26	No	No	0	8	8
137	R:R:F180	R:R:V184	9.18	No	No	0	4	7
138	R:R:F180	R:R:I185	3.77	No	No	0	4	6
139	R:R:E182	R:R:W316	9.81	No	Yes	0	8	9
140	L:L:?1	R:R:E182	8.73	Yes	No	0	0	8
141	R:R:A317	R:R:F183	4.16	No	Yes	0	7	9
142	R:R:I185	R:R:P186	3.39	No	No	0	6	9
143	R:R:F312	R:R:V187	3.93	No	No	0	9	6
144	R:R:L309	R:R:V190	4.47	No	No	0	8	9
145	R:R:F193	R:R:Y192	7.22	No	No	0	7	5
146	R:R:N196	R:R:Y192	9.3	No	No	0	6	5
147	R:R:L305	R:R:N194	6.87	Yes	No	0	8	9
148	R:R:W199	R:R:W202	4.69	No	No	0	4	6
149	R:R:L201	R:R:S200	4.5	No	No	0	8	6
150	R:R:L201	R:R:L301	6.92	No	No	0	8	8
151	R:R:L301	R:R:L305	5.54	No	Yes	6	8	8
152	R:R:L308	R:R:Y358	5.86	No	Yes	0	8	9
153	R:R:F312	R:R:W316	10.02	No	Yes	1	9	9
154	R:R:C315	R:R:N350	6.3	No	No	0	8	9
155	R:R:Q347	R:R:W316	17.52	No	Yes	1	8	9
156	R:R:N350	R:R:W316	6.78	No	Yes	0	9	9
157	R:R:T323	R:R:Y319	7.49	Yes	Yes	1	7	7
158	R:R:Y319	R:R:Y340	10.92	Yes	No	1	7	5
159	R:R:F344	R:R:Y319	7.22	No	Yes	1	6	7
160	R:R:Q347	R:R:Y319	6.76	No	Yes	1	8	7
161	L:L:?1	R:R:Y319	4.41	Yes	Yes	1	0	7
162	R:R:T323	R:R:Y340	6.24	Yes	No	1	7	5
163	R:R:F328	R:R:Y329	13.41	No	No	0	5	5
164	R:R:F344	R:R:W348	5.01	No	Yes	1	6	8
165	L:L:?1	R:R:F344	6.88	Yes	No	1	0	6
166	L:L:?1	R:R:Q347	17.54	Yes	No	1	0	8
167	R:R:N350	R:R:N354	12.26	No	Yes	0	9	9
168	R:R:N354	R:R:P355	3.26	Yes	No	0	9	9
169	R:R:F369	R:R:L360	4.87	Yes	No	0	8	6
170	R:R:F373	R:R:I372	7.54	No	No	0	7	6
171	R:R:V311	R:R:V353	3.21	No	No	0	6	7
172	R:R:A368	R:R:D43	3.09	No	Yes	0	8	7
173	R:R:I372	R:R:V42	3.07	No	No	0	6	6
174	R:R:I342	R:R:V338	3.07	No	No	0	5	1
175	R:R:F322	R:R:W339	3.01	No	No	0	6	5
176	R:R:L46	R:R:S51	3	No	No	0	9	9
177	R:R:L175	R:R:S327	3	Yes	No	0	7	6
178	R:R:L38	R:R:V42	2.98	No	No	0	4	6
179	R:R:L189	R:R:V106	2.98	No	No	0	7	7
180	R:R:L145	R:R:V141	2.98	No	No	0	4	4
181	R:R:L357	R:R:V353	2.98	No	No	0	8	7
182	R:R:N104	R:R:V139	2.96	No	No	0	8	8
183	R:R:N194	R:R:V190	2.96	No	No	0	9	9
184	R:R:F54	R:R:P359	2.89	Yes	No	0	8	8
185	R:R:Q125	R:R:S121	2.89	No	No	0	5	5
186	R:R:E171	R:R:S170	2.87	No	No	0	6	3
187	R:R:I37	R:R:L55	2.85	No	No	0	8	7
188	R:R:I197	R:R:L201	2.85	Yes	No	0	9	8
189	R:R:I197	R:R:L305	2.85	Yes	Yes	0	9	8
190	R:R:I29	R:R:N33	2.83	No	Yes	0	8	9
191	R:R:L18	R:R:L77	2.77	No	Yes	0	5	6
192	R:R:L308	R:R:L357	2.77	No	No	0	8	8
193	R:R:A302	R:R:Y198	2.67	No	Yes	0	7	7
194	R:R:A343	R:R:Y319	2.67	No	Yes	0	5	7
195	R:R:L360	R:R:Q366	2.66	No	No	0	6	9
196	R:R:E155	R:R:L152	2.65	No	No	0	6	5
197	R:R:F183	R:R:S320	2.64	Yes	No	0	9	8
198	R:R:F183	R:R:V187	2.62	Yes	No	0	9	6
199	R:R:S156	R:R:W157	2.47	No	No	0	5	6
200	R:R:V153	R:R:W157	2.45	No	No	0	5	6
201	R:R:L46	R:R:R364	2.43	No	No	0	9	7
202	R:R:L308	R:R:R112	2.43	No	No	0	8	9
203	R:R:K336	R:R:Y340	2.39	No	No	0	4	5
204	R:R:L142	R:R:Y103	2.34	No	No	0	5	7
205	R:R:F365	R:R:F369	2.14	No	Yes	0	8	8
206	R:R:F349	R:R:W345	2	No	No	0	4	8
207	R:R:W345	R:R:Y72	1.93	No	Yes	0	8	7
208	R:R:W202	R:R:Y198	1.93	No	Yes	0	6	7
209	R:R:A317	R:R:P318	1.87	No	No	0	7	9
210	R:R:A343	R:R:P318	1.87	No	No	0	5	9
211	R:R:G167	R:R:S154	1.86	No	No	0	6	8
212	R:R:G65	R:R:V64	1.84	No	Yes	0	8	8
213	R:R:G128	R:R:T127	1.82	No	No	0	4	8
214	R:R:P186	R:R:V106	1.77	No	No	0	9	7
215	R:R:G148	R:R:I151	1.76	No	Yes	0	5	7
216	R:R:G167	R:R:K158	1.74	No	No	0	6	6
217	R:R:G32	R:R:L31	1.71	No	No	0	8	4
218	R:R:D81	R:R:G83	1.68	No	No	0	3	7
219	R:R:L145	R:R:P149	1.64	No	No	0	4	8
220	R:R:L346	R:R:P318	1.64	No	No	0	8	9
221	R:R:A176	R:R:I324	1.62	No	No	0	6	6
222	R:R:V137	R:R:V141	1.6	No	No	0	4	4
223	R:R:T92	R:R:V88	1.59	No	Yes	0	6	7
224	R:R:A19	R:R:L77	1.58	No	Yes	0	5	6
225	R:R:A191	R:R:L309	1.58	No	No	0	5	8
226	R:R:T14	R:R:T17	1.57	No	No	0	5	3
227	R:R:I67	R:R:S68	1.55	No	Yes	0	6	8
228	R:R:I69	R:R:V25	1.54	Yes	No	0	8	7
229	R:R:I37	R:R:V41	1.54	No	No	0	8	3
230	R:R:I188	R:R:V184	1.54	No	No	0	4	7
231	R:R:K336	R:R:S337	1.53	No	No	0	4	2
232	R:R:K158	R:R:V88	1.52	No	Yes	0	6	7
233	R:R:I151	R:R:T92	1.52	Yes	No	0	7	6
234	R:R:L181	R:R:V146	1.49	No	No	0	5	7
235	R:R:L326	R:R:V325	1.49	No	No	0	5	6
236	R:R:L12	R:R:T14	1.47	No	No	0	3	5
237	R:R:L18	R:R:T17	1.47	No	No	0	5	3
238	R:R:E163	R:R:S162	1.44	No	No	0	4	3
239	R:R:K367	R:R:K371	1.44	No	No	0	5	5
240	R:R:E85	R:R:V88	1.43	No	Yes	0	3	7
241	R:R:I307	R:R:L357	1.43	No	No	0	7	8
242	R:R:Q125	R:R:T124	1.42	No	No	0	5	5
243	R:R:D43	R:R:K367	1.38	Yes	No	0	7	5
244	R:R:L107	R:R:L135	1.38	No	No	0	8	7
245	R:R:L356	R:R:L360	1.38	No	No	0	6	6
246	R:R:F322	R:R:V325	1.31	No	No	0	6	6
247	R:R:R123	R:R:T124	1.29	No	No	0	5	5
248	R:R:F27	R:R:M30	1.24	No	No	0	5	6
249	R:R:K44	R:R:R47	1.24	No	No	0	7	8
250	R:R:F369	R:R:L35	1.22	Yes	No	0	8	8
251	R:R:F183	R:R:L321	1.22	Yes	No	0	9	6
252	R:R:L301	R:R:Y198	1.17	No	Yes	6	8	7
253	R:R:L305	R:R:Y198	1.17	Yes	Yes	6	8	7
254	R:R:I342	R:R:W339	1.17	No	No	0	5	5
255	R:R:R299	R:R:R300	1.07	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N33	5.0525	4	0	9
2	R:R:D43	4.5025	4	0	7
3	R:R:R49	7.302	5	2	7
4	R:R:F53	6.705	4	2	8
5	R:R:F54	7.344	5	4	8
6	R:R:D61	6.472	5	3	9
7	R:R:V64	3.565	4	0	8
8	R:R:S68	4.358	5	1	8
9	R:R:I69	4.2125	4	0	8
10	R:R:Y72	9.22	4	1	7
11	R:R:L77	4.3175	4	0	6
12	R:R:F82	11.3425	4	5	6
13	R:R:V88	3.275	4	0	7
14	R:R:W90	4.935	4	1	7
15	R:R:V102	4.98	4	1	8
16	R:R:Y113	7.6875	4	0	9
17	R:R:I151	2.7375	4	1	7
18	R:R:P166	5.912	5	1	7
19	R:R:F168	7.19333	6	1	6
20	R:R:F169	6.928	5	1	6
21	R:R:L175	5.5075	4	1	7
22	R:R:F183	2.66	4	0	9
23	R:R:I197	5.02	4	0	9
24	R:R:Y198	1.735	4	6	7
25	R:R:L305	4.1075	4	6	8
26	R:R:W316	10.298	5	1	9
27	R:R:Y319	6.57833	6	1	7
28	R:R:T323	6.16	4	1	7
29	R:R:W348	6.67833	6	1	8
30	R:R:N354	6.95	5	0	9
31	R:R:Y358	5.808	5	4	9
32	R:R:F369	3.0975	4	0	8
33	L:L:?1	12.4329	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F82	R:R:H75	10.9136	18.1	Yes	No	0	6	6
2	R:R:C164	R:R:H75	12.2542	7.37	No	No	0	9	6
3	R:R:C164	R:R:L91	15.1326	4.76	No	No	0	9	6
4	R:R:L91	R:R:P166	16.0188	3.28	No	Yes	1	6	7
5	R:R:P166	R:R:Y95	53.3358	5.56	Yes	No	0	7	8
6	L:L:?1	R:R:Y95	55.8284	32	Yes	No	0	0	8
7	L:L:?1	R:R:D94	10.4762	11.5	Yes	No	1	0	8
8	R:R:W348	R:R:Y72	14.1979	13.5	Yes	Yes	1	8	7
9	R:R:T76	R:R:Y72	15.4842	13.73	No	Yes	0	5	7
10	R:R:L77	R:R:T76	13.7005	4.42	Yes	No	0	6	5
11	R:R:D61	R:R:S351	21.1497	7.36	Yes	No	0	9	9
12	R:R:S351	R:R:V64	20.9296	3.23	No	Yes	0	9	8
13	R:R:S68	R:R:V64	22.4931	3.23	Yes	Yes	0	8	8
14	R:R:D61	R:R:N354	29.0704	8.08	Yes	Yes	0	9	9
15	R:R:L57	R:R:N354	54.6021	5.49	No	Yes	0	9	9
16	R:R:L57	R:R:Y358	54.1762	3.52	No	Yes	0	9	9
17	R:R:F54	R:R:Y358	100	5.16	Yes	Yes	4	8	9
18	R:R:F365	R:R:F54	30.7455	8.57	No	Yes	0	8	8
19	R:R:F365	R:R:F369	17.7853	2.14	No	Yes	0	8	8
20	R:R:F369	R:R:L35	10.2647	1.22	Yes	No	0	8	8
21	R:R:I105	R:R:N354	54.7965	5.66	No	Yes	0	9	9
22	R:R:I105	R:R:Y358	54.3706	8.46	No	Yes	0	9	9
23	R:R:F40	R:R:Y52	11.0593	4.13	No	No	0	8	6
24	R:R:I132	R:R:Y52	23.6565	3.63	No	No	0	7	6
25	R:R:I132	R:R:R49	23.5708	5.01	No	Yes	2	7	7
26	R:R:H48	R:R:R49	67.3908	5.64	No	Yes	0	7	7
27	R:R:H48	R:R:S50	68.6657	4.18	No	No	0	7	8
28	R:R:H362	R:R:S50	69.932	11.16	No	No	0	9	8
29	R:R:F54	R:R:H362	71.2154	11.31	Yes	No	0	8	9
30	R:R:L46	R:R:S51	10.7621	3	No	No	0	9	9
31	R:R:F365	R:R:S51	12.2685	5.28	No	No	0	8	9
32	R:R:D111	R:R:R49	39.8811	7.15	No	Yes	2	9	7
33	R:R:M136	R:R:Y52	11.3223	7.18	No	No	0	8	6
34	R:R:F168	R:R:S154	19.1973	6.61	Yes	No	0	6	8
35	R:R:F168	R:R:P166	18.6457	10.11	Yes	Yes	1	6	7
36	R:R:I151	R:R:T92	10.5248	1.52	Yes	No	0	7	6
37	R:R:I151	R:R:P166	20.9381	3.39	Yes	Yes	1	7	7
38	R:R:F169	R:R:T323	12.2799	6.49	Yes	Yes	1	6	7
39	R:R:T323	R:R:Y319	26.2692	7.49	Yes	Yes	1	7	7
40	R:R:L175	R:R:T323	13.8806	4.42	Yes	Yes	1	7	7
41	L:L:?1	R:R:E182	28.5359	8.73	Yes	No	0	0	8
42	R:R:E182	R:R:W316	29.3506	9.81	No	Yes	0	8	9
43	R:R:V102	R:R:W316	14.4523	7.36	Yes	Yes	1	8	9
44	L:L:?1	R:R:Q347	27.7756	17.54	Yes	No	1	0	8
45	R:R:Q347	R:R:W316	54.8937	17.52	No	Yes	1	8	9
46	R:R:Q347	R:R:Y319	26.9666	6.76	No	Yes	1	8	7
47	R:R:P186	R:R:V102	10.1818	3.53	No	Yes	0	9	8
48	R:R:D111	R:R:Y122	40.1155	8.05	No	No	0	9	8
49	R:R:S115	R:R:Y122	38.9035	8.9	No	No	0	8	8
50	R:R:S115	R:R:V116	37.4457	3.23	No	No	0	8	8
51	R:R:I197	R:R:V116	35.9707	10.75	Yes	No	0	9	8
52	R:R:I197	R:R:L305	16.8448	2.85	Yes	Yes	0	9	8
53	R:R:I197	R:R:Y113	14.1808	3.63	Yes	Yes	0	9	9
54	R:R:F168	R:R:I174	11.328	3.77	Yes	No	1	6	8
55	R:R:N350	R:R:W316	87.0426	6.78	No	Yes	0	9	9
56	R:R:N350	R:R:N354	86.6653	12.26	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D94	R:R:S68	5.89	1	No	Yes	8	8	1	2
R:R:S68	R:R:W348	7.41	1	Yes	Yes	8	8	2	2
R:R:D94	R:R:W348	3.35	1	No	Yes	8	8	1	2
L:L:?1	R:R:D94	11.5	1	Yes	No	0	8	0	1
R:R:N147	R:R:Y95	11.63	0	No	No	8	8	2	1
R:R:P166	R:R:Y95	5.56	1	Yes	No	7	8	2	1
L:L:?1	R:R:Y95	32	1	Yes	No	0	8	0	1
L:L:?1	R:R:C98	5.97	1	Yes	No	0	8	0	1
R:R:E182	R:R:T99	4.23	0	No	No	8	8	1	2
R:R:E182	R:R:W316	9.81	0	No	Yes	8	9	1	2
L:L:?1	R:R:E182	8.73	1	Yes	No	0	8	0	1
R:R:Q347	R:R:W316	17.52	1	No	Yes	8	9	1	2
R:R:T323	R:R:Y319	7.49	1	Yes	Yes	7	7	2	1
R:R:Y319	R:R:Y340	10.92	1	Yes	No	7	5	1	2
R:R:F344	R:R:Y319	7.22	1	No	Yes	6	7	1	1
R:R:Q347	R:R:Y319	6.76	1	No	Yes	8	7	1	1
L:L:?1	R:R:Y319	4.41	1	Yes	Yes	0	7	0	1
R:R:T323	R:R:Y340	6.24	1	Yes	No	7	5	2	2
R:R:F344	R:R:W348	5.01	1	No	Yes	6	8	1	2
L:L:?1	R:R:F344	6.88	1	Yes	No	0	6	0	1
L:L:?1	R:R:Q347	17.54	1	Yes	No	0	8	0	1
R:R:A343	R:R:Y319	2.67	0	No	Yes	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YFC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	230
Number of Links	255
Number of Hubs	33
Number of Links mediated by Hubs	125
Number of Communities	6
Number of Nodes involved in Communities	39
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	58251
Length Of Smallest Path	3
Average Path Length	15.286
Length of Longest Path	31
Minimum Path Strength	1.355
Average Path Strength	7.43133
Maximum Path Strength	24.77
Minimum Path Correlation	0.7
Average Path Correlation	0.920476
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	42.5554
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.9988
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • regulation of intracellular signal transduction • regulation of response to stimulus • MAPK cascade • regulation of cell communication • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	1H-Imidazole-4-ethanamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>7YFC_nogp_Chain_R L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D K N L R H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N A V S Y R T Q H T G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K G S E C E P G F F S E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F Q K A F L K I F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	9LRC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	-	2.84	2025-06-11	To be published
	9LRE	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.84	2025-06-11	To be published
	9LRE (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.84	2025-06-11	To be published
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3

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