psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L12	R:R:R15	8.5	No	No	0	3	3
2	R:R:L77	R:R:R15	4.86	Yes	No	5	6	3
3	R:R:F78	R:R:R15	6.41	No	No	5	5	3
4	R:R:L18	R:R:L77	6.92	No	Yes	0	5	6
5	R:R:F20	R:R:F21	6.43	No	No	0	4	4
6	R:R:I73	R:R:M22	4.37	No	No	0	6	7
7	R:R:L77	R:R:M22	4.24	Yes	No	0	6	7
8	R:R:M22	R:R:W345	9.31	No	Yes	0	7	8
9	R:R:F349	R:R:V25	3.93	No	No	0	4	7
10	R:R:A26	R:R:I69	4.87	No	No	0	7	8
11	R:R:A26	R:R:P70	3.74	No	No	0	7	9
12	R:R:F27	R:R:M30	4.98	No	No	0	5	6
13	R:R:F27	R:R:L31	3.65	No	No	0	5	4
14	R:R:A28	R:R:F352	4.16	No	No	0	4	6
15	R:R:I29	R:R:S351	4.64	No	No	0	8	9
16	R:R:A58	R:R:N33	4.69	No	No	0	9	9
17	R:R:D61	R:R:N33	10.77	Yes	No	0	9	9
18	R:R:N33	R:R:P355	13.03	No	No	0	9	9
19	R:R:P359	R:R:V36	7.07	No	No	0	8	9
20	R:R:I37	R:R:L55	4.28	No	No	0	8	7
21	R:R:I372	R:R:L38	4.28	No	No	0	6	4
22	R:R:A39	R:R:F369	4.16	No	No	0	8	8
23	R:R:F40	R:R:R47	14.97	No	No	6	8	8
24	R:R:F40	R:R:Y52	7.22	No	Yes	6	8	6
25	R:R:F40	R:R:L55	15.83	No	No	0	8	7
26	R:R:I372	R:R:V42	6.14	No	No	0	6	6
27	R:R:D43	R:R:N45	13.46	Yes	No	0	7	6
28	R:R:D43	R:R:L46	8.14	Yes	Yes	0	7	9
29	R:R:A368	R:R:D43	4.63	No	Yes	0	8	7
30	R:R:D43	R:R:K371	4.15	Yes	No	0	7	5
31	R:R:L46	R:R:S51	4.5	Yes	No	7	9	9
32	R:R:L46	R:R:R364	3.64	Yes	No	0	9	7
33	R:R:F365	R:R:L46	10.96	Yes	Yes	7	8	9
34	R:R:R47	R:R:Y52	6.17	No	Yes	6	8	6
35	R:R:H48	R:R:S51	4.18	No	No	0	7	9
36	R:R:H48	R:R:R364	23.7	No	No	0	7	7
37	R:R:F53	R:R:R49	6.41	No	No	2	8	7
38	R:R:D111	R:R:R49	10.72	No	No	2	9	7
39	R:R:R49	R:R:T127	10.35	No	Yes	2	7	8
40	R:R:F365	R:R:S51	5.28	Yes	No	7	8	9
41	R:R:I132	R:R:Y52	7.25	No	Yes	0	7	6
42	R:R:M136	R:R:Y52	3.59	No	Yes	0	8	6
43	R:R:F53	R:R:L107	13.4	No	No	0	8	8
44	R:R:D111	R:R:F53	8.36	No	No	2	9	8
45	R:R:F54	R:R:I108	6.28	Yes	No	0	8	9
46	R:R:F54	R:R:P359	8.67	Yes	No	0	8	8
47	R:R:F54	R:R:H362	4.53	Yes	No	0	8	9
48	R:R:F365	R:R:F54	6.43	Yes	Yes	0	8	8
49	R:R:N104	R:R:N56	12.26	Yes	No	0	8	9
50	R:R:M136	R:R:N56	12.62	No	No	0	8	9
51	R:R:N56	R:R:W140	11.3	No	Yes	0	9	9
52	R:R:D61	R:R:L57	4.07	Yes	No	0	9	9
53	R:R:L57	R:R:N104	4.12	No	Yes	0	9	8
54	R:R:F63	R:R:I59	3.77	Yes	No	0	6	6
55	R:R:S101	R:R:S60	4.89	No	No	0	9	9
56	R:R:N104	R:R:S60	4.47	Yes	No	0	8	9
57	R:R:S60	R:R:W140	7.41	No	Yes	0	9	9
58	R:R:D61	R:R:S101	4.42	Yes	No	0	9	9
59	R:R:D61	R:R:S351	8.83	Yes	No	0	9	9
60	R:R:D61	R:R:N354	5.39	Yes	No	0	9	9
61	R:R:F62	R:R:F63	4.29	No	Yes	0	8	6
62	R:R:F62	R:R:V66	5.24	No	No	0	8	5
63	R:R:F63	R:R:I67	6.28	Yes	No	0	6	6
64	R:R:F63	R:R:L97	6.09	Yes	No	0	6	6
65	R:R:L97	R:R:V64	4.47	No	No	0	6	8
66	R:R:V64	R:R:W348	3.68	No	Yes	0	8	8
67	R:R:S351	R:R:V64	4.85	No	No	0	9	8
68	R:R:D94	R:R:S68	7.36	No	No	0	8	8
69	R:R:I69	R:R:W348	12.92	No	Yes	0	8	8
70	R:R:L71	R:R:W90	4.56	No	No	0	5	7
71	R:R:T76	R:R:Y72	13.73	No	Yes	0	5	7
72	R:R:W90	R:R:Y72	9.65	No	Yes	0	7	7
73	R:R:F344	R:R:Y72	7.22	Yes	Yes	1	6	7
74	R:R:W345	R:R:Y72	4.82	Yes	Yes	1	8	7
75	R:R:W348	R:R:Y72	8.68	Yes	Yes	1	8	7
76	R:R:P74	R:R:W80	6.76	No	No	0	5	9
77	R:R:F82	R:R:H75	13.58	Yes	No	0	6	6
78	R:R:L77	R:R:T76	4.42	Yes	No	0	6	5
79	R:R:F78	R:R:L77	3.65	No	Yes	5	5	6
80	R:R:F82	R:R:W80	4.01	Yes	No	0	6	9
81	R:R:F82	R:R:I86	3.77	Yes	No	0	6	5
82	R:R:F82	R:R:W90	4.01	Yes	No	0	6	7
83	R:R:G83	R:R:I86	5.29	No	No	0	7	5
84	R:R:C164	R:R:C87	7.28	No	No	9	9	9
85	R:R:F89	R:R:T93	3.89	No	No	0	4	5
86	R:R:I151	R:R:L91	4.28	Yes	No	0	7	6
87	R:R:C164	R:R:L91	4.76	No	No	0	9	6
88	R:R:I151	R:R:T92	4.56	Yes	No	0	7	6
89	R:R:D94	R:R:W348	12.28	No	Yes	1	8	8
90	L:L:?1	R:R:D94	10.22	Yes	No	1	0	8
91	R:R:N147	R:R:Y95	9.3	Yes	Yes	1	8	8
92	R:R:I151	R:R:Y95	3.63	Yes	Yes	0	7	8
93	R:R:P166	R:R:Y95	5.56	No	Yes	0	7	8
94	L:L:?1	R:R:Y95	16.55	Yes	Yes	1	0	8
95	R:R:Y95	W:W:?1	14.84	Yes	Yes	1	8	0
96	R:R:L96	R:R:W140	6.83	No	Yes	0	6	9
97	L:L:?1	R:R:C98	5.97	Yes	No	0	0	8
98	R:R:T99	R:R:Y103	6.24	Yes	Yes	0	8	7
99	R:R:N147	R:R:T99	5.85	Yes	Yes	1	8	8
100	R:R:E182	R:R:T99	5.64	Yes	Yes	1	8	8
101	R:R:A100	R:R:W140	5.19	No	Yes	0	8	9
102	R:R:V102	R:R:Y103	3.79	Yes	Yes	0	8	7
103	R:R:F312	R:R:V102	7.87	Yes	Yes	1	9	8
104	R:R:V102	R:R:W316	7.36	Yes	Yes	1	8	9
105	R:R:V139	R:R:Y103	3.79	No	Yes	0	8	7
106	R:R:V146	R:R:Y103	6.31	No	Yes	0	7	7
107	R:R:N104	R:R:V139	7.39	Yes	No	0	8	8
108	R:R:I105	R:R:N354	5.66	No	No	0	9	9
109	R:R:I105	R:R:Y358	9.67	No	Yes	0	9	9
110	R:R:I108	R:R:R112	6.26	No	No	8	9	9
111	R:R:I108	R:R:Y358	4.84	No	Yes	8	9	9
112	R:R:S109	R:R:V190	4.85	No	Yes	0	9	9
113	R:R:F193	R:R:S109	3.96	Yes	No	0	7	9
114	R:R:L114	R:R:Y110	16.41	No	No	0	5	6
115	R:R:F193	R:R:Y110	9.28	Yes	No	0	7	6
116	R:R:D111	R:R:Y122	11.49	No	No	0	9	8
117	R:R:R112	R:R:Y358	8.23	No	Yes	8	9	9
118	R:R:S117	R:R:Y113	10.17	No	Yes	0	7	9
119	R:R:Y113	R:R:Y192	5.96	Yes	No	3	9	5
120	R:R:F193	R:R:Y113	11.35	Yes	Yes	3	7	9
121	R:R:N196	R:R:Y113	8.14	No	Yes	3	6	9
122	R:R:S115	R:R:Y122	7.63	No	No	0	8	8
123	R:R:N118	R:R:S121	7.45	No	No	0	6	5
124	R:R:Q125	R:R:T127	4.25	No	Yes	2	5	8
125	R:R:K131	R:R:Q125	4.07	No	No	2	7	5
126	R:R:K131	R:R:T127	6.01	No	Yes	2	7	8
127	R:R:I132	R:R:T127	4.56	No	Yes	0	7	8
128	R:R:F144	R:R:G148	4.52	No	No	0	5	5
129	R:R:F144	R:R:P149	5.78	No	No	0	5	8
130	R:R:N147	R:R:V146	7.39	Yes	No	0	8	7
131	R:R:L181	R:R:V146	5.96	No	No	0	5	7
132	R:R:N147	R:R:T178	4.39	Yes	No	0	8	8
133	R:R:E182	R:R:N147	13.15	Yes	Yes	1	8	8
134	R:R:F168	R:R:M150	7.46	No	No	0	6	7
135	R:R:E155	R:R:W157	37.07	No	No	0	6	6
136	R:R:K158	R:R:S162	7.65	No	No	0	6	3
137	R:R:D159	R:R:E160	15.59	No	No	0	4	3
138	R:R:E163	R:R:E165	7.61	No	No	0	4	4
139	R:R:E163	R:R:G334	4.91	No	No	0	4	1
140	R:R:E165	R:R:F169	5.83	No	Yes	0	4	6
141	R:R:E165	R:R:T333	11.29	No	No	0	4	6
142	R:R:F168	R:R:P166	10.11	No	No	0	6	7
143	R:R:F169	R:R:P166	13	Yes	No	0	6	7
144	R:R:F168	R:R:I174	6.28	No	No	0	6	8
145	R:R:F169	R:R:L175	9.74	Yes	No	1	6	7
146	R:R:F169	R:R:T323	5.19	Yes	Yes	1	6	7
147	R:R:A332	R:R:F169	4.16	No	Yes	0	1	6
148	R:R:E171	R:R:S170	8.62	No	No	0	6	3
149	R:R:E171	R:R:Y173	17.96	No	No	0	6	4
150	R:R:W172	R:R:Y173	4.82	No	No	0	4	4
151	R:R:F328	R:R:W172	13.03	No	No	0	5	4
152	R:R:L175	R:R:T323	5.9	No	Yes	1	7	7
153	R:R:F180	R:R:V184	7.87	No	No	0	4	7
154	R:R:F180	R:R:I185	11.3	No	No	0	4	6
155	R:R:E182	R:R:W316	4.36	Yes	Yes	1	8	9
156	R:R:E182	W:W:?1	10.67	Yes	Yes	1	8	0
157	R:R:F183	R:R:V187	5.24	Yes	No	1	9	6
158	R:R:F183	R:R:F312	6.43	Yes	Yes	1	9	9
159	R:R:F183	R:R:W316	5.01	Yes	Yes	1	9	9
160	R:R:A317	R:R:F183	4.16	No	Yes	0	7	9
161	R:R:I185	R:R:P186	5.08	No	No	0	6	9
162	R:R:F312	R:R:V187	5.24	Yes	No	1	9	6
163	R:R:F193	R:R:L189	3.65	Yes	No	0	7	7
164	R:R:N194	R:R:V190	4.43	No	Yes	0	9	9
165	R:R:F193	R:R:Y192	5.16	Yes	No	3	7	5
166	R:R:N196	R:R:Y192	16.28	No	No	3	6	5
167	R:R:L305	R:R:N194	9.61	No	No	0	8	9
168	R:R:M195	R:R:W199	11.63	No	No	0	3	4
169	R:R:N196	R:R:W199	5.65	No	No	0	6	4
170	R:R:W202	R:R:Y198	11.58	No	Yes	0	6	7
171	R:R:L201	R:R:R204	7.29	No	No	4	8	8
172	R:R:L201	R:R:R297	8.5	No	No	4	8	7
173	R:R:L201	R:R:L301	4.15	No	No	0	8	8
174	R:R:E294	R:R:R204	16.28	Yes	No	4	5	8
175	R:R:R204	R:R:R297	5.33	No	No	4	8	7
176	R:R:E294	R:R:H292	11.08	Yes	No	0	5	5
177	R:R:H292	R:R:L295	14.14	No	No	0	5	4
178	R:R:E294	R:R:R297	9.3	Yes	No	4	5	7
179	R:R:L295	R:R:R299	6.07	No	No	0	4	6
180	R:R:L296	R:R:R299	8.5	No	No	0	4	6
181	R:R:L308	R:R:L357	5.54	No	No	0	8	8
182	R:R:L308	R:R:Y358	8.21	No	Yes	0	8	9
183	R:R:L357	R:R:V311	4.47	No	No	0	8	6
184	R:R:F312	R:R:W316	4.01	Yes	Yes	1	9	9
185	R:R:Q347	R:R:W316	19.71	Yes	Yes	1	8	9
186	R:R:W316	W:W:?1	9.17	Yes	Yes	1	9	0
187	R:R:T323	R:R:Y319	8.74	Yes	Yes	1	7	7
188	R:R:Y319	R:R:Y340	8.94	Yes	Yes	1	7	5
189	R:R:A343	R:R:Y319	4	No	Yes	0	5	7
190	R:R:F344	R:R:Y319	8.25	Yes	Yes	1	6	7
191	R:R:Q347	R:R:Y319	11.27	Yes	Yes	1	8	7
192	L:L:?1	R:R:Y319	9.93	Yes	Yes	1	0	7
193	R:R:Y319	W:W:?1	8.09	Yes	Yes	1	7	0
194	R:R:S320	W:W:?1	5.18	No	Yes	0	8	0
195	R:R:T323	R:R:Y340	3.75	Yes	Yes	1	7	5
196	R:R:L326	R:R:Y340	4.69	No	Yes	0	5	5
197	R:R:F328	R:R:Y329	13.41	No	No	0	5	5
198	R:R:S331	R:R:T333	6.4	No	No	0	3	6
199	R:R:G334	R:R:T333	3.64	No	No	0	1	6
200	R:R:G334	R:R:P335	4.06	No	No	0	1	4
201	R:R:K336	R:R:Y340	14.33	No	Yes	0	4	5
202	R:R:F344	R:R:W348	11.02	Yes	Yes	1	6	8
203	L:L:?1	R:R:F344	30.95	Yes	Yes	1	0	6
204	R:R:W345	R:R:W348	12.18	Yes	Yes	1	8	8
205	R:R:F349	R:R:W345	4.01	No	Yes	0	4	8
206	L:L:?1	R:R:Q347	17.54	Yes	Yes	1	0	8
207	R:R:Q347	W:W:?1	9.19	Yes	Yes	1	8	0
208	L:L:?1	R:R:W348	10.72	Yes	Yes	1	0	8
209	R:R:N350	R:R:N354	13.62	No	No	0	9	9
210	R:R:F352	R:R:L356	4.87	No	No	0	6	6
211	R:R:L357	R:R:V353	4.47	No	No	0	8	7
212	R:R:H362	R:R:R364	13.54	No	No	0	9	7
213	R:R:K363	R:R:Q366	10.85	No	No	0	5	9
214	L:L:?1	W:W:?1	10.49	Yes	Yes	1	0	0
215	R:R:G65	R:R:I29	3.53	No	No	0	8	8
216	R:R:P186	R:R:V102	3.53	No	Yes	0	9	8
217	R:R:G148	R:R:I151	3.53	No	Yes	0	5	7
218	R:R:K203	R:R:W199	3.48	No	No	0	6	4
219	R:R:A143	R:R:T99	3.36	No	Yes	0	8	8
220	R:R:S115	R:R:V116	3.23	No	No	0	8	8
221	R:R:S200	R:R:V116	3.23	No	No	0	6	8
222	R:R:S154	R:R:V153	3.23	No	No	0	8	5
223	R:R:F365	R:R:F369	3.22	Yes	No	0	8	8
224	R:R:V106	R:R:V190	3.21	No	Yes	0	7	9
225	R:R:T124	R:R:V120	3.17	No	No	0	5	7
226	R:R:A191	R:R:L309	3.15	No	No	0	5	8
227	R:R:C315	R:R:N350	3.15	No	No	0	8	9
228	R:R:I324	R:R:S179	3.1	No	No	0	6	8
229	R:R:I197	R:R:V116	3.07	No	No	0	9	8
230	R:R:M30	R:R:V66	3.04	No	No	0	6	5
231	R:R:I67	R:R:T93	3.04	No	No	0	6	5
232	R:R:L175	R:R:S327	3	No	No	0	7	6
233	R:R:L309	R:R:V190	2.98	No	Yes	0	8	9
234	R:R:L18	R:R:T17	2.95	No	No	0	5	3
235	R:R:L152	R:R:T92	2.95	No	No	0	5	6
236	R:R:I307	R:R:K303	2.91	No	No	0	7	7
237	R:R:I185	R:R:L189	2.85	No	No	0	6	7
238	R:R:I197	R:R:L305	2.85	No	No	0	9	8
239	R:R:K131	R:R:L135	2.82	No	No	0	7	7
240	R:R:A19	R:R:F78	2.77	No	No	0	5	5
241	R:R:A34	R:R:F62	2.77	No	No	0	4	8
242	R:R:L301	R:R:L305	2.77	No	No	0	8	8
243	R:R:A343	R:R:F322	2.77	No	No	0	5	6
244	R:R:L356	R:R:L360	2.77	No	No	0	6	6
245	R:R:E171	R:R:I174	2.73	No	No	0	6	8
246	R:R:A298	R:R:Y198	2.67	No	Yes	0	8	7
247	R:R:A302	R:R:Y198	2.67	No	Yes	0	7	7
248	R:R:F54	R:R:S50	2.64	Yes	No	0	8	8
249	R:R:V325	R:R:Y329	2.52	No	No	0	6	5
250	R:R:S337	R:R:W339	2.47	No	No	0	2	5
251	R:R:F349	R:R:L346	2.44	No	No	0	4	8
252	R:R:L142	R:R:Y103	2.34	No	Yes	0	5	7
253	R:R:L301	R:R:Y198	2.34	No	Yes	0	8	7
254	R:R:A313	R:R:G310	1.95	No	No	0	6	6
255	R:R:A317	R:R:P318	1.87	No	No	0	7	9
256	R:R:A343	R:R:P318	1.87	No	No	0	5	9
257	R:R:G32	R:R:L31	1.71	No	No	0	8	4
258	R:R:G32	R:R:L35	1.71	No	No	0	8	8
259	R:R:G310	R:R:L309	1.71	No	No	0	6	8
260	R:R:C315	R:R:V314	1.71	No	No	0	8	4
261	R:R:A39	R:R:I372	1.62	No	No	0	8	6
262	R:R:C87	R:R:K158	1.62	No	No	9	9	6
263	R:R:C164	R:R:K158	1.62	No	No	9	9	6
264	R:R:A176	R:R:I324	1.62	No	No	0	6	6
265	R:R:V129	R:R:V133	1.6	No	No	0	4	3
266	R:R:V137	R:R:V141	1.6	No	No	0	4	4
267	R:R:T17	R:R:V16	1.59	No	No	0	3	5
268	R:R:T92	R:R:V88	1.59	No	No	0	6	7
269	R:R:C374	R:R:L370	1.59	No	No	0	4	5
270	R:R:I73	R:R:S23	1.55	No	No	0	6	5
271	R:R:I188	R:R:V184	1.54	No	No	0	4	7
272	R:R:I188	R:R:V187	1.54	No	No	0	4	6
273	R:R:I307	R:R:V311	1.54	No	No	0	7	6
274	R:R:I324	R:R:T323	1.52	No	Yes	0	6	7
275	R:R:L326	R:R:S330	1.5	No	No	0	5	2
276	R:R:N118	R:R:S117	1.49	No	No	0	6	7
277	R:R:L130	R:R:V133	1.49	No	No	0	5	3
278	R:R:L18	R:R:T14	1.47	No	No	0	5	5
279	R:R:I177	R:R:L181	1.43	No	No	0	5	5
280	R:R:E294	R:R:V293	1.43	Yes	No	0	5	5
281	R:R:I342	R:R:L346	1.43	No	No	0	5	8
282	R:R:C374	R:R:F373	1.4	No	No	0	4	7
283	R:R:F21	R:R:T17	1.3	No	No	0	4	3
284	R:R:S337	R:R:Y340	1.27	No	Yes	0	2	5
285	R:R:F352	R:R:I29	1.26	No	No	0	6	8
286	R:R:V129	R:R:Y52	1.26	No	Yes	0	4	6
287	R:R:K44	R:R:R47	1.24	No	No	0	7	8
288	R:R:F27	R:R:L24	1.22	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D43	7.595	4	0	7
2	R:R:L46	6.81	4	7	9
3	R:R:Y52	5.098	5	6	6
4	R:R:F54	5.71	5	0	8
5	R:R:D61	6.696	5	0	9
6	R:R:F63	5.1075	4	0	6
7	R:R:Y72	8.82	5	1	7
8	R:R:L77	4.818	5	5	6
9	R:R:F82	6.3425	4	0	6
10	R:R:Y95	9.976	5	1	8
11	R:R:T99	5.2725	4	1	8
12	R:R:V102	5.6375	4	1	8
13	R:R:Y103	4.494	5	0	7
14	R:R:N104	7.06	4	0	8
15	R:R:Y113	8.905	4	3	9
16	R:R:T127	6.2925	4	2	8
17	R:R:W140	7.6825	4	0	9
18	R:R:N147	8.016	5	1	8
19	R:R:I151	4	4	0	7
20	R:R:F169	7.584	5	1	6
21	R:R:E182	8.455	4	1	8
22	R:R:F183	5.21	4	1	9
23	R:R:V190	3.8675	4	0	9
24	R:R:F193	6.68	5	3	7
25	R:R:Y198	4.815	4	0	7
26	R:R:E294	9.5225	4	4	5
27	R:R:F312	5.8875	4	1	9
28	R:R:W316	8.27	6	1	9
29	R:R:Y319	8.46	7	1	7
30	R:R:T323	5.02	5	1	7
31	R:R:Y340	6.596	5	1	5
32	R:R:F344	14.36	4	1	6
33	R:R:W345	7.58	4	1	8
34	R:R:Q347	14.4275	4	1	8
35	R:R:W348	10.2114	7	1	8
36	R:R:Y358	7.7375	4	8	9
37	R:R:F365	6.4725	4	7	8
38	L:L:?1	14.0463	8	1	0
39	W:W:?1	9.66143	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L18	R:R:L77	26.7473	6.92	No	Yes	0	5	6
2	R:R:L18	R:R:T17	17.8688	2.95	No	No	0	5	3
3	R:R:L77	R:R:M22	15.0226	4.24	Yes	No	0	6	7
4	R:R:M22	R:R:W345	20.3118	9.31	No	Yes	0	7	8
5	R:R:W348	R:R:Y72	27.8353	8.68	Yes	Yes	1	8	7
6	R:R:T76	R:R:Y72	36.6798	13.73	No	Yes	0	5	7
7	R:R:L77	R:R:T76	33.6685	4.42	Yes	No	0	6	5
8	R:R:W345	R:R:W348	27.7575	12.18	Yes	Yes	1	8	8
9	R:R:M30	R:R:V66	10.8067	3.04	No	No	0	6	5
10	R:R:F62	R:R:V66	12.5747	5.24	No	No	0	8	5
11	R:R:F62	R:R:F63	16.0814	4.29	No	Yes	0	8	6
12	R:R:F63	R:R:L97	24.6782	6.09	Yes	No	0	6	6
13	R:R:L97	R:R:V64	26.3684	4.47	No	No	0	6	8
14	R:R:V64	R:R:W348	66.8512	3.68	No	Yes	0	8	8
15	R:R:I29	R:R:S351	12.089	4.64	No	No	0	8	9
16	R:R:S351	R:R:V64	51.0758	4.85	No	No	0	9	8
17	R:R:D61	R:R:S351	45.704	8.83	Yes	No	0	9	9
18	R:R:D61	R:R:N354	46.0149	5.39	Yes	No	0	9	9
19	R:R:I105	R:R:N354	41.1385	5.66	No	No	0	9	9
20	R:R:I105	R:R:Y358	39.8951	9.67	No	Yes	0	9	9
21	R:R:I108	R:R:Y358	29.6518	4.84	No	Yes	8	9	9
22	R:R:F54	R:R:I108	28.4181	6.28	Yes	No	0	8	9
23	R:R:M136	R:R:Y52	28.8115	3.59	No	Yes	0	8	6
24	R:R:M136	R:R:N56	30.0743	12.62	No	No	0	8	9
25	R:R:N104	R:R:N56	33.0176	12.26	Yes	No	0	8	9
26	R:R:L57	R:R:N104	29.5692	4.12	No	Yes	0	9	8
27	R:R:D61	R:R:L57	29.6615	4.07	Yes	No	0	9	9
28	R:R:F365	R:R:F54	18.6653	6.43	Yes	Yes	0	8	8
29	R:R:R49	R:R:T127	11.817	10.35	No	Yes	2	7	8
30	R:R:I132	R:R:T127	16.3971	4.56	No	Yes	0	7	8
31	R:R:I132	R:R:Y52	17.6793	7.25	No	Yes	0	7	6
32	R:R:W90	R:R:Y72	24.6879	9.65	No	Yes	0	7	7
33	R:R:F344	R:R:Y72	36.0581	7.22	Yes	Yes	1	6	7
34	R:R:F82	R:R:W90	18.7333	4.01	Yes	No	0	6	7
35	R:R:I151	R:R:Y95	19.0636	3.63	Yes	Yes	0	7	8
36	L:L:?1	R:R:Y95	27.0047	16.55	Yes	Yes	1	0	8
37	L:L:?1	R:R:F344	18.9227	30.95	Yes	Yes	1	0	6
38	L:L:?1	R:R:W348	77.76	10.72	Yes	Yes	1	0	8
39	R:R:N147	R:R:Y95	20.2244	9.3	Yes	Yes	1	8	8
40	R:R:P166	R:R:Y95	28.3744	5.56	No	Yes	0	7	8
41	L:L:?1	W:W:?1	33.9647	10.49	Yes	Yes	1	0	0
42	R:R:F344	R:R:Y319	28.7872	8.25	Yes	Yes	1	6	7
43	R:R:Y319	W:W:?1	22.2303	8.09	Yes	Yes	1	7	0
44	R:R:T99	R:R:Y103	14.498	6.24	Yes	Yes	0	8	7
45	R:R:N147	R:R:V146	11.2342	7.39	Yes	No	0	8	7
46	R:R:V146	R:R:Y103	10.5299	6.31	No	Yes	0	7	7
47	L:L:?1	R:R:Q347	30.5309	17.54	Yes	Yes	1	0	8
48	R:R:Q347	R:R:W316	47.0494	19.71	Yes	Yes	1	8	9
49	R:R:V102	R:R:W316	92.6466	7.36	Yes	Yes	1	8	9
50	R:R:V102	R:R:Y103	29.7926	3.79	Yes	Yes	0	8	7
51	R:R:Q347	R:R:Y319	17.0091	11.27	Yes	Yes	1	8	7
52	R:R:W316	W:W:?1	57.9096	9.17	Yes	Yes	1	9	0
53	R:R:N104	R:R:V139	41.5805	7.39	Yes	No	0	8	8
54	R:R:V139	R:R:Y103	43.8827	3.79	No	Yes	0	8	7
55	R:R:P186	R:R:V102	100	3.53	No	Yes	0	9	8
56	R:R:I185	R:R:P186	98.2369	5.08	No	No	0	6	9
57	R:R:I185	R:R:L189	95.1188	2.85	No	No	0	6	7
58	R:R:F193	R:R:L189	93.346	3.65	Yes	No	0	7	7
59	R:R:F193	R:R:S109	64.4325	3.96	Yes	No	0	7	9
60	R:R:S109	R:R:V190	62.5431	4.85	No	Yes	0	9	9
61	R:R:F193	R:R:Y113	17.9076	11.35	Yes	Yes	3	7	9
62	R:R:F193	R:R:Y192	11.1904	5.16	Yes	No	3	7	5
63	R:R:F168	R:R:P166	15.8288	10.11	No	No	0	6	7
64	R:R:E165	R:R:F169	22.4537	5.83	No	Yes	0	4	6
65	R:R:F169	R:R:T323	17.0722	5.19	Yes	Yes	1	6	7
66	R:R:T323	R:R:Y319	28.8844	8.74	Yes	Yes	1	7	7
67	R:R:E165	R:R:T333	11.2536	11.29	No	No	0	4	6
68	R:R:F168	R:R:I174	12.7398	6.28	No	No	0	6	8
69	R:R:E171	R:R:I174	11.1807	2.73	No	No	0	6	8
70	R:R:N194	R:R:V190	51.5275	4.43	No	Yes	0	9	9
71	R:R:L305	R:R:N194	49.6673	9.61	No	No	0	8	9
72	R:R:N196	R:R:W199	13.5169	5.65	No	No	0	6	4
73	R:R:L301	R:R:L305	43.4407	2.77	No	No	0	8	8
74	R:R:L201	R:R:L301	33.0371	4.15	No	No	0	8	8
75	R:R:L201	R:R:R204	15.5277	7.29	No	No	4	8	8
76	R:R:L201	R:R:R297	15.5277	8.5	No	No	4	8	7
77	R:R:E294	R:R:R204	13.3372	16.28	Yes	No	4	5	8
78	R:R:E294	R:R:R297	13.3421	9.3	Yes	No	4	5	7
79	R:R:E294	R:R:H292	17.8299	11.08	Yes	No	0	5	5
80	R:R:H292	R:R:L295	13.3858	14.14	No	No	0	5	4
81	R:R:Y319	R:R:Y340	13.3518	8.94	Yes	Yes	1	7	5
82	R:R:F344	R:R:W348	10.5882	11.02	Yes	Yes	1	6	8
83	R:R:F169	R:R:P166	13.9152	13	Yes	No	0	6	7
84	L:L:?1	R:R:Y319	12.0258	9.93	Yes	Yes	1	0	7
85	R:R:Y95	W:W:?1	12.5455	14.84	Yes	Yes	1	8	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V64	R:R:W348	3.68	0	No	Yes	8	8	2	1
R:R:D94	R:R:S68	7.36	1	No	No	8	8	1	2
R:R:I69	R:R:W348	12.92	0	No	Yes	8	8	2	1
R:R:F344	R:R:Y72	7.22	1	Yes	Yes	6	7	1	2
R:R:W345	R:R:Y72	4.82	1	Yes	Yes	8	7	2	2
R:R:W348	R:R:Y72	8.68	1	Yes	Yes	8	7	1	2
R:R:D94	R:R:W348	12.28	1	No	Yes	8	8	1	1
L:L:?1	R:R:D94	10.22	1	Yes	No	0	8	0	1
R:R:N147	R:R:Y95	9.3	1	Yes	Yes	8	8	2	1
R:R:I151	R:R:Y95	3.63	0	Yes	Yes	7	8	2	1
R:R:P166	R:R:Y95	5.56	0	No	Yes	7	8	2	1
L:L:?1	R:R:Y95	16.55	1	Yes	Yes	0	8	0	1
R:R:Y95	W:W:?1	14.84	1	Yes	Yes	8	0	1	1
L:L:?1	R:R:C98	5.97	1	Yes	No	0	8	0	1
R:R:E182	R:R:N147	13.15	1	Yes	Yes	8	8	2	2
R:R:E182	R:R:W316	4.36	1	Yes	Yes	8	9	2	2
R:R:E182	W:W:?1	10.67	1	Yes	Yes	8	0	2	1
R:R:Q347	R:R:W316	19.71	1	Yes	Yes	8	9	1	2
R:R:W316	W:W:?1	9.17	1	Yes	Yes	9	0	2	1
R:R:T323	R:R:Y319	8.74	1	Yes	Yes	7	7	2	1
R:R:Y319	R:R:Y340	8.94	1	Yes	Yes	7	5	1	2
R:R:A343	R:R:Y319	4	0	No	Yes	5	7	2	1
R:R:F344	R:R:Y319	8.25	1	Yes	Yes	6	7	1	1
R:R:Q347	R:R:Y319	11.27	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:Y319	9.93	1	Yes	Yes	0	7	0	1
R:R:Y319	W:W:?1	8.09	1	Yes	Yes	7	0	1	1
R:R:S320	W:W:?1	5.18	0	No	Yes	8	0	2	1
R:R:T323	R:R:Y340	3.75	1	Yes	Yes	7	5	2	2
R:R:F344	R:R:W348	11.02	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:F344	30.95	1	Yes	Yes	0	6	0	1
R:R:W345	R:R:W348	12.18	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:Q347	17.54	1	Yes	Yes	0	8	0	1
R:R:Q347	W:W:?1	9.19	1	Yes	Yes	8	0	1	1
L:L:?1	R:R:W348	10.72	1	Yes	Yes	0	8	0	1
L:L:?1	W:W:?1	10.49	1	Yes	Yes	0	0	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JED_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	254
Number of Links	288
Number of Hubs	39
Number of Links mediated by Hubs	143
Number of Communities	9
Number of Nodes involved in Communities	51
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	56145
Length Of Smallest Path	3
Average Path Length	13.3024
Length of Longest Path	32
Minimum Path Strength	1.43
Average Path Strength	7.01048
Maximum Path Strength	24.245
Minimum Path Correlation	0.7
Average Path Correlation	0.929189
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	51.2112
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.1408
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	beta-aminoethylglyoxaline
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


Code	PO4
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	PO4
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>9JED_nogp_Chain_R L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D K N L R H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N A V S Y R T Q H T G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K D E G S E C E P G F F S E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S S A T G P K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F Q K A F L K I F C I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	9JED	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	2.58	2025-09-10	doi.org/10.1038/s41401-025-01633-4
	9JED (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		2.58	2025-09-10	doi.org/10.1038/s41401-025-01633-4
	9L42	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.9	2025-10-22	doi.org/10.3390/ph18030292
	9L42 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.9	2025-10-22	doi.org/10.3390/ph18030292
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	9LRC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	-	2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9LRE	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9LRE (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9JG1	A	Amine	Histamine	H₄	Homo sapiens	Adriforant	-	-	3.62	2025-12-03	10.1038/s41401-025-01633-4
	9JG1 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Adriforant	-		3.62	2025-12-03	10.1038/s41401-025-01633-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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