psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D94	10.13	Yes	Yes	1	0	8
2	L:L:?1	R:R:Y95	13.12	Yes	Yes	1	0	8
3	L:L:?1	R:R:N147	5.12	Yes	Yes	1	0	8
4	L:L:?1	R:R:E182	12.36	Yes	Yes	0	0	8
5	L:L:?1	R:R:F344	11.36	Yes	Yes	1	0	6
6	L:L:?1	R:R:Q347	19.87	Yes	No	0	0	8
7	L:L:?1	R:R:W348	3.19	Yes	Yes	1	0	8
8	R:R:S11	R:R:T14	4.8	No	No	0	7	5
9	R:R:L12	R:R:R15	3.64	No	No	0	3	3
10	R:R:L18	R:R:T14	2.95	No	No	0	5	5
11	R:R:L77	R:R:R15	3.64	Yes	No	0	6	3
12	R:R:L18	R:R:L77	4.15	No	Yes	0	5	6
13	R:R:A19	R:R:L77	3.15	No	Yes	0	5	6
14	R:R:F20	R:R:S23	3.96	No	No	0	4	5
15	R:R:F20	R:R:L24	10.96	No	No	0	4	5
16	R:R:F21	R:R:V25	3.93	No	No	0	4	7
17	R:R:I69	R:R:M22	2.92	Yes	Yes	1	8	7
18	R:R:M22	R:R:Y72	4.79	Yes	Yes	1	7	7
19	R:R:I73	R:R:M22	5.83	Yes	Yes	0	6	7
20	R:R:M22	R:R:W345	9.31	Yes	Yes	1	7	8
21	R:R:I29	R:R:V25	3.07	No	No	0	8	7
22	R:R:A26	R:R:I69	3.25	No	Yes	0	7	8
23	R:R:I29	R:R:N33	4.25	No	No	0	8	9
24	R:R:F352	R:R:I29	8.79	Yes	No	0	6	8
25	R:R:F62	R:R:M30	4.98	Yes	No	0	8	6
26	R:R:L31	R:R:L35	2.77	No	No	0	4	8
27	R:R:F62	R:R:N33	12.08	Yes	No	0	8	9
28	R:R:N33	R:R:P355	8.15	No	No	0	9	9
29	R:R:A58	R:R:V36	3.39	No	No	0	9	9
30	R:R:V36	R:R:Y358	3.79	No	Yes	0	9	9
31	R:R:I37	R:R:I59	2.94	No	No	0	8	6
32	R:R:L38	R:R:V42	2.98	No	No	0	4	6
33	R:R:A39	R:R:R364	4.15	No	Yes	0	8	7
34	R:R:A39	R:R:F365	5.55	No	No	0	8	8
35	R:R:F40	R:R:V41	3.93	No	No	0	8	3
36	R:R:F40	R:R:S51	5.28	No	No	0	8	9
37	R:R:F40	R:R:L55	14.61	No	No	0	8	7
38	R:R:D43	R:R:V42	4.38	No	No	0	7	6
39	R:R:D43	R:R:R364	19.06	No	Yes	6	7	7
40	R:R:A368	R:R:D43	3.09	No	No	6	8	7
41	R:R:K44	R:R:R47	7.43	No	No	0	7	8
42	R:R:H362	R:R:L46	3.86	No	No	0	9	9
43	R:R:L46	R:R:R364	12.15	No	Yes	0	9	7
44	R:R:R47	R:R:Y52	4.12	No	No	0	8	6
45	R:R:D111	R:R:R49	8.34	Yes	Yes	4	9	7
46	R:R:R49	R:R:S115	10.54	Yes	No	4	7	8
47	R:R:R49	R:R:Y122	6.17	Yes	Yes	4	7	8
48	R:R:I132	R:R:Y52	6.04	No	No	0	7	6
49	R:R:F53	R:R:L107	4.87	Yes	No	0	8	8
50	R:R:D111	R:R:F53	13.14	Yes	Yes	0	9	8
51	R:R:F53	R:R:I132	3.77	Yes	No	0	8	7
52	R:R:F54	R:R:I108	15.07	No	No	0	8	9
53	R:R:F54	R:R:Y358	5.16	No	Yes	0	8	9
54	R:R:I59	R:R:L55	7.14	No	No	0	6	7
55	R:R:N104	R:R:N56	10.9	No	No	0	8	9
56	R:R:M136	R:R:N56	8.41	No	No	0	8	9
57	R:R:N56	R:R:W140	5.65	No	No	0	9	9
58	R:R:L57	R:R:S101	3	No	No	0	9	9
59	R:R:L57	R:R:N354	9.61	No	No	0	9	9
60	R:R:D61	R:R:S60	4.42	Yes	No	0	9	9
61	R:R:L97	R:R:S60	3	No	No	0	6	9
62	R:R:A100	R:R:S60	3.42	No	No	0	8	9
63	R:R:D61	R:R:S101	5.89	Yes	No	0	9	9
64	R:R:D61	R:R:S351	8.83	Yes	No	0	9	9
65	R:R:D61	R:R:N354	5.39	Yes	No	0	9	9
66	R:R:F62	R:R:F63	4.29	Yes	No	0	8	6
67	R:R:F62	R:R:V66	5.24	Yes	No	0	8	5
68	R:R:F63	R:R:L97	3.65	No	No	0	6	6
69	R:R:G65	R:R:V64	3.68	No	Yes	0	8	8
70	R:R:S68	R:R:V64	6.46	Yes	Yes	0	8	8
71	R:R:L97	R:R:V64	4.47	No	Yes	0	6	8
72	R:R:S351	R:R:V64	3.23	No	Yes	0	9	8
73	R:R:I67	R:R:T93	10.64	No	No	0	6	5
74	R:R:S68	R:R:W90	3.71	Yes	Yes	1	8	7
75	R:R:D94	R:R:S68	10.31	Yes	Yes	1	8	8
76	R:R:S68	R:R:W348	8.65	Yes	Yes	1	8	8
77	R:R:I69	R:R:P70	3.39	Yes	No	0	8	9
78	R:R:I69	R:R:W345	5.87	Yes	Yes	1	8	8
79	R:R:I69	R:R:W348	4.7	Yes	Yes	1	8	8
80	R:R:L71	R:R:W90	7.97	No	Yes	0	5	7
81	R:R:T76	R:R:Y72	16.23	No	Yes	0	5	7
82	R:R:W90	R:R:Y72	2.89	Yes	Yes	1	7	7
83	R:R:F344	R:R:Y72	3.09	Yes	Yes	1	6	7
84	R:R:W348	R:R:Y72	12.54	Yes	Yes	1	8	7
85	R:R:I73	R:R:P74	3.39	Yes	No	0	6	5
86	R:R:I73	R:R:L77	7.14	Yes	Yes	0	6	6
87	R:R:F78	R:R:I73	3.77	No	Yes	0	5	6
88	R:R:F82	R:R:P74	7.22	Yes	No	0	6	5
89	R:R:H75	R:R:T76	6.85	No	No	0	6	5
90	R:R:H75	R:R:W80	8.46	No	Yes	3	6	9
91	R:R:C164	R:R:H75	2.95	Yes	No	3	9	6
92	R:R:L77	R:R:T76	2.95	Yes	No	0	6	5
93	R:R:F82	R:R:W80	8.02	Yes	Yes	0	6	9
94	R:R:C87	R:R:W80	5.22	No	Yes	3	9	9
95	R:R:E163	R:R:W80	9.81	Yes	Yes	3	4	9
96	R:R:C164	R:R:W80	3.92	Yes	Yes	3	9	9
97	R:R:D81	R:R:F82	7.17	No	Yes	0	3	6
98	R:R:F82	R:R:I86	10.05	Yes	No	0	6	5
99	R:R:E163	R:R:K84	5.4	Yes	No	0	4	3
100	R:R:C87	R:R:E163	4.56	No	Yes	3	9	4
101	R:R:C164	R:R:C87	7.28	Yes	No	3	9	9
102	R:R:E155	R:R:V88	2.85	No	No	0	6	7
103	R:R:F89	R:R:T93	5.19	No	No	0	4	5
104	R:R:L91	R:R:W90	6.83	No	Yes	0	6	7
105	R:R:D94	R:R:W90	3.35	Yes	Yes	1	8	7
106	R:R:F344	R:R:W90	4.01	Yes	Yes	1	6	7
107	R:R:T92	R:R:Y95	13.73	No	Yes	0	6	8
108	R:R:D94	R:R:W348	6.7	Yes	Yes	1	8	8
109	R:R:N147	R:R:Y95	9.3	Yes	Yes	1	8	8
110	R:R:G148	R:R:Y95	5.79	No	Yes	1	5	8
111	R:R:T99	R:R:Y103	8.74	Yes	No	0	8	7
112	R:R:A143	R:R:T99	5.03	No	Yes	0	8	8
113	R:R:N147	R:R:T99	5.85	Yes	Yes	0	8	8
114	R:R:E182	R:R:T99	2.82	Yes	Yes	0	8	8
115	R:R:P186	R:R:V102	3.53	No	No	0	9	8
116	R:R:F312	R:R:V102	3.93	Yes	No	0	9	8
117	R:R:V146	R:R:Y103	6.31	No	No	0	7	7
118	R:R:N104	R:R:V139	4.43	No	No	0	8	8
119	R:R:S109	R:R:V106	3.23	No	No	0	9	7
120	R:R:P186	R:R:V106	3.53	No	No	0	9	7
121	R:R:L107	R:R:L135	4.15	No	No	0	8	7
122	R:R:L107	R:R:V139	4.47	No	No	0	8	8
123	R:R:S109	R:R:V190	6.46	No	No	0	9	9
124	R:R:F193	R:R:S109	5.28	Yes	No	0	7	9
125	R:R:L114	R:R:Y110	15.24	No	No	0	5	6
126	R:R:F193	R:R:Y110	9.28	Yes	No	0	7	6
127	R:R:D111	R:R:S115	4.42	Yes	No	4	9	8
128	R:R:D111	R:R:Y122	3.45	Yes	Yes	4	9	8
129	R:R:L301	R:R:R112	13.36	No	No	0	8	9
130	R:R:S117	R:R:Y113	17.8	No	No	0	7	9
131	R:R:F193	R:R:Y113	17.54	Yes	No	0	7	9
132	R:R:N196	R:R:Y113	9.3	No	No	0	6	9
133	R:R:L114	R:R:N118	2.75	No	No	0	5	6
134	R:R:S115	R:R:Y122	5.09	No	Yes	4	8	8
135	R:R:I197	R:R:V116	15.36	Yes	No	7	9	8
136	R:R:L201	R:R:V116	2.98	Yes	No	7	8	8
137	R:R:N118	R:R:S117	5.96	No	No	0	6	7
138	R:R:A119	R:R:R123	4.15	No	No	0	8	5
139	R:R:T127	R:R:Y122	8.74	No	Yes	0	8	8
140	R:R:K131	R:R:T127	10.51	No	No	0	7	8
141	R:R:I132	R:R:V129	4.61	No	No	0	7	4
142	R:R:F144	R:R:G148	6.02	No	No	1	5	5
143	R:R:F144	R:R:P149	7.22	No	No	1	5	8
144	R:R:N147	R:R:V146	5.91	Yes	No	0	8	7
145	R:R:G148	R:R:P149	4.06	No	No	1	5	8
146	R:R:E155	R:R:I151	2.73	No	No	0	6	7
147	R:R:F168	R:R:I151	12.56	Yes	No	0	6	7
148	R:R:E155	R:R:L152	5.3	No	No	0	6	5
149	R:R:I174	R:R:S154	3.1	Yes	No	0	8	8
150	R:R:D159	R:R:W157	6.7	No	No	0	4	6
151	R:R:G167	R:R:W157	4.22	No	No	0	6	6
152	R:R:S170	R:R:W157	3.71	No	No	0	3	6
153	R:R:E165	R:R:S162	12.94	No	No	0	4	3
154	R:R:K336	R:R:S162	4.59	No	No	0	4	3
155	R:R:C164	R:R:E163	6.08	Yes	Yes	3	9	4
156	R:R:E165	R:R:P335	3.14	No	No	0	4	4
157	R:R:F168	R:R:P166	5.78	Yes	No	2	6	7
158	R:R:F169	R:R:P166	13	Yes	No	2	6	7
159	R:R:F168	R:R:F169	9.65	Yes	Yes	2	6	6
160	R:R:F168	R:R:I174	6.28	Yes	Yes	2	6	8
161	R:R:F168	R:R:L175	7.31	Yes	Yes	2	6	7
162	R:R:F169	R:R:L175	8.53	Yes	Yes	2	6	7
163	R:R:F169	R:R:Y319	5.16	Yes	Yes	2	6	7
164	R:R:F169	R:R:T323	12.97	Yes	No	2	6	7
165	R:R:F169	R:R:Y340	4.13	Yes	No	2	6	5
166	R:R:S170	R:R:S330	3.26	No	No	0	3	2
167	R:R:E171	R:R:Y173	14.59	No	No	2	6	4
168	R:R:E171	R:R:I174	6.83	No	Yes	2	6	8
169	R:R:I174	R:R:Y173	10.88	Yes	No	2	8	4
170	R:R:L175	R:R:T323	4.42	Yes	No	2	7	7
171	R:R:I324	R:R:L175	4.28	No	Yes	0	6	7
172	R:R:I177	R:R:L181	2.85	No	No	0	5	5
173	R:R:S179	R:R:W316	6.18	No	Yes	0	8	9
174	R:R:F180	R:R:V184	18.35	No	No	0	4	7
175	R:R:F180	R:R:I185	5.02	No	No	0	4	6
176	R:R:E182	R:R:F312	3.5	Yes	Yes	0	8	9
177	R:R:E182	R:R:W316	15.27	Yes	Yes	0	8	9
178	R:R:F183	R:R:V187	7.87	Yes	No	0	9	6
179	R:R:F183	R:R:F312	3.22	Yes	Yes	0	9	9
180	R:R:A313	R:R:F183	2.77	No	Yes	0	6	9
181	R:R:F183	R:R:W316	14.03	Yes	Yes	0	9	9
182	R:R:I185	R:R:P186	3.39	No	No	0	6	9
183	R:R:L309	R:R:V187	7.45	No	No	0	8	6
184	R:R:F193	R:R:L189	4.87	Yes	No	0	7	7
185	R:R:N194	R:R:V190	4.43	No	No	0	9	9
186	R:R:N196	R:R:Y192	19.77	No	No	0	6	5
187	R:R:L305	R:R:N194	2.75	No	No	0	8	9
188	R:R:I197	R:R:L201	2.85	Yes	Yes	7	9	8
189	R:R:R299	R:R:Y198	5.14	No	No	0	6	7
190	R:R:W199	R:R:W202	4.69	No	No	0	4	6
191	R:R:K203	R:R:W199	16.24	No	No	0	6	4
192	R:R:L201	R:R:L295	2.77	Yes	No	0	8	4
193	R:R:H206	R:R:W202	13.75	No	No	0	5	6
194	R:R:E291	R:R:R204	13.96	No	No	0	5	8
195	R:R:E291	R:R:R290	3.49	No	No	0	5	5
196	R:R:H292	R:R:L296	6.43	No	No	0	5	4
197	R:R:K303	R:R:R299	6.19	No	No	0	7	6
198	R:R:L301	R:R:L305	2.77	No	No	0	8	8
199	R:R:C361	R:R:S304	5.16	No	No	0	7	8
200	R:R:N350	R:R:V311	2.96	No	No	0	9	6
201	R:R:F312	R:R:N350	7.25	Yes	No	0	9	9
202	R:R:C315	R:R:L346	4.76	No	No	0	8	8
203	R:R:C315	R:R:N350	9.45	No	No	0	8	9
204	R:R:S320	R:R:W316	13.59	No	Yes	0	8	9
205	R:R:L346	R:R:P318	4.93	No	No	0	8	9
206	R:R:Y319	R:R:Y340	9.93	Yes	No	2	7	5
207	R:R:Q347	R:R:Y319	12.4	No	Yes	0	8	7
208	R:R:F322	R:R:W339	14.03	No	No	0	6	5
209	R:R:G334	R:R:Y329	2.9	No	No	0	1	5
210	R:R:P335	R:R:S330	5.34	No	No	0	4	2
211	R:R:S337	R:R:W339	21	No	No	0	2	5
212	R:R:R341	R:R:V338	3.92	No	No	0	6	1
213	R:R:F344	R:R:W348	13.03	Yes	Yes	1	6	8
214	R:R:W345	R:R:W348	14.99	Yes	Yes	1	8	8
215	R:R:F349	R:R:W345	15.03	No	Yes	0	4	8
216	R:R:F349	R:R:F352	3.22	No	Yes	0	4	6
217	R:R:F352	R:R:V353	3.93	Yes	No	5	6	7
218	R:R:F352	R:R:L356	4.87	Yes	No	5	6	6
219	R:R:L356	R:R:V353	2.98	No	No	5	6	7
220	R:R:L357	R:R:V353	2.98	No	No	0	8	7
221	R:R:N354	R:R:P355	4.89	No	No	0	9	9
222	R:R:P359	R:R:Y358	2.78	No	Yes	0	8	9
223	R:R:H362	R:R:Y358	7.62	No	Yes	0	9	9
224	R:R:F365	R:R:P359	8.67	No	No	0	8	8
225	R:R:K363	R:R:L360	4.23	No	No	0	5	6
226	R:R:A368	R:R:R364	2.77	No	Yes	6	8	7
227	R:R:A343	R:R:Y319	2.67	No	Yes	0	5	7
228	R:R:E294	R:R:L201	2.65	No	Yes	0	5	8
229	R:R:R112	R:R:S50	2.64	No	No	0	9	8
230	R:R:R204	R:R:S200	2.64	No	No	0	8	6
231	R:R:A100	R:R:W140	2.59	No	No	0	8	9
232	R:R:F53	R:R:I108	2.51	Yes	No	0	8	9
233	R:R:F63	R:R:I59	2.51	No	No	0	6	6
234	R:R:F27	R:R:M30	2.49	No	No	0	5	6
235	R:R:K367	R:R:R364	2.48	No	Yes	0	5	7
236	R:R:F27	R:R:L31	2.44	No	No	0	5	4
237	R:R:F365	R:R:L35	2.44	No	No	0	8	8
238	R:R:F144	R:R:L145	2.44	No	No	0	5	4
239	R:R:T93	R:R:W90	2.43	No	Yes	0	5	7
240	R:R:L201	R:R:R204	2.43	Yes	No	0	8	8
241	R:R:L142	R:R:Y103	2.34	No	No	0	5	7
242	R:R:L326	R:R:Y329	2.34	No	No	0	5	5
243	R:R:H126	R:R:R49	2.26	No	Yes	0	7	7
244	R:R:E165	R:R:Y340	2.24	No	No	0	4	5
245	R:R:G334	R:R:P335	2.03	No	No	0	1	4
246	R:R:A313	R:R:G310	1.95	No	No	0	6	6
247	R:R:A317	R:R:P318	1.87	No	No	0	7	9
248	R:R:G128	R:R:T127	1.82	No	No	0	4	8
249	R:R:G83	R:R:I86	1.76	No	No	0	7	5
250	R:R:G32	R:R:L31	1.71	No	No	0	8	4
251	R:R:A332	R:R:S331	1.71	No	No	0	1	3
252	R:R:S121	R:R:V120	1.62	No	No	0	5	7
253	R:R:A298	R:R:I197	1.62	No	Yes	0	8	9
254	R:R:V133	R:R:V137	1.6	No	No	0	3	4
255	R:R:A143	R:R:L96	1.58	No	No	0	8	6
256	R:R:A302	R:R:N194	1.56	No	No	0	7	9
257	R:R:I105	R:R:S101	1.55	No	No	0	9	9
258	R:R:I188	R:R:V184	1.54	No	No	0	4	7
259	R:R:I324	R:R:V325	1.54	No	No	0	6	6
260	R:R:I342	R:R:V338	1.54	No	No	0	5	1
261	R:R:C98	R:R:E182	1.52	No	Yes	0	8	8
262	R:R:M136	R:R:V133	1.52	No	No	0	8	3
263	R:R:M150	R:R:T178	1.51	No	No	0	7	8
264	R:R:L175	R:R:S327	1.5	Yes	No	0	7	6
265	R:R:L308	R:R:S304	1.5	No	No	0	8	8
266	R:R:L321	R:R:S320	1.5	No	No	0	6	8
267	R:R:N118	R:R:S121	1.49	No	No	0	6	5
268	R:R:L130	R:R:V129	1.49	No	No	0	5	4
269	R:R:L145	R:R:V141	1.49	No	No	0	4	4
270	R:R:L181	R:R:V146	1.49	No	No	0	5	7
271	R:R:C361	R:R:H362	1.47	No	No	0	7	9
272	R:R:N147	R:R:T178	1.46	Yes	No	0	8	8
273	R:R:K363	R:R:K367	1.44	No	No	0	5	5
274	R:R:I307	R:R:L360	1.43	No	No	0	7	6
275	R:R:Q125	R:R:T124	1.42	No	No	0	5	5
276	R:R:A28	R:R:F352	1.39	No	Yes	0	4	6
277	R:R:H48	R:R:S50	1.39	No	No	0	7	8
278	R:R:A343	R:R:F322	1.39	No	No	0	5	6
279	R:R:L46	R:R:N45	1.37	No	No	0	9	6
280	R:R:K363	R:R:Q366	1.36	No	No	0	5	9
281	R:R:D205	R:R:E291	1.3	No	No	0	5	5
282	R:R:I197	R:R:R112	1.25	Yes	No	0	9	9
283	R:R:L296	R:R:R299	1.21	No	No	0	4	6
284	R:R:L295	R:R:Y198	1.17	No	No	0	4	7
285	R:R:F328	R:R:Y329	1.03	No	No	0	5	5
286	R:R:W172	R:R:Y173	0.96	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.7357	7	1	0
2	R:R:M22	5.7125	4	1	7
3	R:R:R49	6.8275	4	4	7
4	R:R:F53	6.0725	4	0	8
5	R:R:D61	6.1325	4	0	9
6	R:R:F62	6.6475	4	0	8
7	R:R:V64	4.46	4	0	8
8	R:R:S68	7.2825	4	1	8
9	R:R:I69	4.026	5	1	8
10	R:R:Y72	7.908	5	1	7
11	R:R:I73	5.0325	4	0	6
12	R:R:L77	4.206	5	0	6
13	R:R:W80	7.086	5	3	9
14	R:R:F82	8.115	4	0	6
15	R:R:W90	4.45571	7	1	7
16	R:R:D94	7.6225	4	1	8
17	R:R:Y95	10.485	4	1	8
18	R:R:T99	5.61	4	0	8
19	R:R:D111	7.3375	4	4	9
20	R:R:Y122	5.8625	4	4	8
21	R:R:N147	5.528	5	1	8
22	R:R:E163	6.4625	4	3	4
23	R:R:C164	5.0575	4	3	9
24	R:R:F168	8.316	5	2	6
25	R:R:F169	8.90667	6	2	6
26	R:R:I174	6.7725	4	2	8
27	R:R:L175	5.208	5	2	7
28	R:R:E182	7.094	5	0	8
29	R:R:F183	6.9725	4	0	9
30	R:R:F193	9.2425	4	0	7
31	R:R:I197	5.27	4	7	9
32	R:R:L201	2.736	5	7	8
33	R:R:F312	4.475	4	0	9
34	R:R:W316	12.2675	4	0	9
35	R:R:Y319	7.54	4	2	7
36	R:R:F344	7.8725	4	1	6
37	R:R:W345	11.3	4	1	8
38	R:R:W348	9.11429	7	1	8
39	R:R:F352	4.44	5	5	6
40	R:R:Y358	4.8375	4	0	9
41	R:R:R364	8.122	5	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F344	18.9176	11.36	Yes	Yes	1	0	6
2	R:R:F344	R:R:Y72	15.437	3.09	Yes	Yes	1	6	7
3	R:R:T76	R:R:Y72	34.8934	16.23	No	Yes	0	5	7
4	R:R:L77	R:R:T76	11.8737	2.95	Yes	No	0	6	5
5	L:L:?1	R:R:W348	71.4898	3.19	Yes	Yes	1	0	8
6	R:R:W348	R:R:Y72	23.8732	12.54	Yes	Yes	1	8	7
7	R:R:W345	R:R:W348	13.734	14.99	Yes	Yes	1	8	8
8	R:R:F349	R:R:W345	11.3545	15.03	No	Yes	0	4	8
9	R:R:F349	R:R:F352	10.6112	3.22	No	Yes	0	4	6
10	R:R:M22	R:R:Y72	12.2945	4.79	Yes	Yes	1	7	7
11	R:R:I73	R:R:M22	22.5793	5.83	Yes	Yes	0	6	7
12	L:L:?1	R:R:D94	43.2903	10.13	Yes	Yes	1	0	8
13	R:R:D94	R:R:S68	39.9984	10.31	Yes	Yes	1	8	8
14	R:R:S68	R:R:V64	100	6.46	Yes	Yes	0	8	8
15	R:R:L97	R:R:V64	86.8796	4.47	No	Yes	0	6	8
16	R:R:F63	R:R:L97	49.709	3.65	No	No	0	6	6
17	R:R:F62	R:R:F63	40.2934	4.29	Yes	No	0	8	6
18	R:R:S68	R:R:W348	52.0334	8.65	Yes	Yes	1	8	8
19	R:R:F62	R:R:M30	41.08	4.98	Yes	No	0	8	6
20	R:R:F27	R:R:M30	39.7703	2.49	No	No	0	5	6
21	R:R:F27	R:R:L31	38.4646	2.44	No	No	0	5	4
22	R:R:L31	R:R:L35	35.8452	2.77	No	No	0	4	8
23	R:R:S351	R:R:V64	11.1815	3.23	No	Yes	0	9	8
24	R:R:F365	R:R:L35	34.5159	2.44	No	No	0	8	8
25	R:R:F365	R:R:P359	14.4419	8.67	No	No	0	8	8
26	R:R:P359	R:R:Y358	13.0654	2.78	No	Yes	0	8	9
27	R:R:F63	R:R:I59	10.1432	2.51	No	No	0	6	6
28	R:R:A39	R:R:F365	19.2283	5.55	No	No	0	8	8
29	R:R:A39	R:R:R364	17.6945	4.15	No	Yes	0	8	7
30	R:R:L97	R:R:S60	41.4182	3	No	No	0	6	9
31	R:R:A100	R:R:S60	41.2412	3.42	No	No	0	8	9
32	R:R:A100	R:R:W140	39.7585	2.59	No	No	0	8	9
33	R:R:N56	R:R:W140	38.3584	5.65	No	No	0	9	9
34	R:R:N104	R:R:N56	32.7263	10.9	No	No	0	8	9
35	R:R:N104	R:R:V139	31.3105	4.43	No	No	0	8	8
36	R:R:L107	R:R:V139	29.8985	4.47	No	No	0	8	8
37	R:R:F53	R:R:L107	27.0353	4.87	Yes	No	0	8	8
38	R:R:F53	R:R:I132	10.5207	3.77	Yes	No	0	8	7
39	R:R:D111	R:R:F53	13.6081	13.14	Yes	Yes	0	9	8
40	R:R:I73	R:R:P74	15.6218	3.39	Yes	No	0	6	5
41	R:R:F82	R:R:P74	12.5895	7.22	Yes	No	0	6	5
42	R:R:H75	R:R:T76	21.8005	6.85	No	No	0	6	5
43	R:R:H75	R:R:W80	12.7979	8.46	No	Yes	3	6	9
44	L:L:?1	R:R:Q347	50.8849	19.87	Yes	No	0	0	8
45	R:R:Q347	R:R:Y319	49.6146	12.4	No	Yes	0	8	7
46	R:R:F169	R:R:Y319	23.7985	5.16	Yes	Yes	2	6	7
47	R:R:F168	R:R:F169	14.6464	9.65	Yes	Yes	2	6	6
48	L:L:?1	R:R:Y95	10.0999	13.12	Yes	Yes	1	0	8
49	L:L:?1	R:R:N147	16.8607	5.12	Yes	Yes	1	0	8
50	L:L:?1	R:R:E182	89.5776	12.36	Yes	Yes	0	0	8
51	R:R:E182	R:R:F312	74.7463	3.5	Yes	Yes	0	8	9
52	R:R:F312	R:R:V102	62.0979	3.93	Yes	No	0	9	8
53	R:R:P186	R:R:V102	60.9101	3.53	No	No	0	9	8
54	R:R:P186	R:R:V106	54.8533	3.53	No	No	0	9	7
55	R:R:S109	R:R:V106	53.6183	3.23	No	No	0	9	7
56	R:R:S109	R:R:V190	34.2602	6.46	No	No	0	9	9
57	R:R:F193	R:R:S109	20.7229	5.28	Yes	No	0	7	9
58	R:R:N194	R:R:V190	32.8994	4.43	No	No	0	9	9
59	R:R:L305	R:R:N194	30.2997	2.75	No	No	0	8	9
60	R:R:L301	R:R:L305	28.9192	2.77	No	No	0	8	8
61	R:R:L301	R:R:R112	27.5112	13.36	No	No	0	8	9
62	R:R:F193	R:R:Y113	10.5129	17.54	Yes	No	0	7	9
63	R:R:I197	R:R:R112	23.535	1.25	Yes	No	0	9	9
64	R:R:I197	R:R:L201	19.2126	2.85	Yes	Yes	7	9	8
65	R:R:Y319	R:R:Y340	19.5469	9.93	Yes	No	2	7	5
66	R:R:E165	R:R:Y340	19.1969	2.24	No	No	0	4	5
67	R:R:E165	R:R:P335	15.0083	3.14	No	No	0	4	4
68	R:R:E182	R:R:W316	12.4046	15.27	Yes	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D94	10.13	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y95	13.12	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N147	5.12	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:E182	12.36	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F344	11.36	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q347	19.87	1	Yes	No	0	8	0	1
L:L:?1	R:R:W348	3.19	1	Yes	Yes	0	8	0	1
R:R:S68	R:R:W90	3.71	1	Yes	Yes	8	7	2	2
R:R:D94	R:R:S68	10.31	1	Yes	Yes	8	8	1	2
R:R:S68	R:R:W348	8.65	1	Yes	Yes	8	8	2	1
R:R:I69	R:R:W345	5.87	1	Yes	Yes	8	8	2	2
R:R:I69	R:R:W348	4.7	1	Yes	Yes	8	8	2	1
R:R:W90	R:R:Y72	2.89	1	Yes	Yes	7	7	2	2
R:R:F344	R:R:Y72	3.09	1	Yes	Yes	6	7	1	2
R:R:W348	R:R:Y72	12.54	1	Yes	Yes	8	7	1	2
R:R:D94	R:R:W90	3.35	1	Yes	Yes	8	7	1	2
R:R:F344	R:R:W90	4.01	1	Yes	Yes	6	7	1	2
R:R:T92	R:R:Y95	13.73	0	No	Yes	6	8	2	1
R:R:D94	R:R:W348	6.7	1	Yes	Yes	8	8	1	1
R:R:N147	R:R:Y95	9.3	1	Yes	Yes	8	8	1	1
R:R:G148	R:R:Y95	5.79	1	No	Yes	5	8	2	1
R:R:N147	R:R:T99	5.85	1	Yes	Yes	8	8	1	2
R:R:E182	R:R:T99	2.82	0	Yes	Yes	8	8	1	2
R:R:N147	R:R:V146	5.91	1	Yes	No	8	7	1	2
R:R:E182	R:R:F312	3.5	0	Yes	Yes	8	9	1	2
R:R:E182	R:R:W316	15.27	0	Yes	Yes	8	9	1	2
R:R:Q347	R:R:Y319	12.4	0	No	Yes	8	7	1	2
R:R:F344	R:R:W348	13.03	1	Yes	Yes	6	8	1	1
R:R:W345	R:R:W348	14.99	1	Yes	Yes	8	8	2	1
R:R:C98	R:R:E182	1.52	0	No	Yes	8	8	2	1
R:R:N147	R:R:T178	1.46	1	Yes	No	8	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JG1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.73
Number of Linked Nodes	254
Number of Links	286
Number of Hubs	41
Number of Links mediated by Hubs	140
Number of Communities	7
Number of Nodes involved in Communities	43
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	54203
Length Of Smallest Path	3
Average Path Length	14.4831
Length of Longest Path	36
Minimum Path Strength	1.4
Average Path Strength	6.45824
Maximum Path Strength	17.67
Minimum Path Correlation	0.7
Average Path Correlation	0.923102
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	48.7954
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.2912
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • MAPK cascade • regulation of cell communication • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • periplasmic space • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>9JG1_nogp_Chain_R S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D K N L R H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N A V S Y R T Q H T G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K D E G S E C E P G F F S E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R D H L Q R E H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S S A T G P K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F Q K A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	doi.org/10.1038/s41422-023-00835-x
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	doi.org/10.1038/s41467-023-42260-z
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	9JED	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	2.58	2025-09-10	doi.org/10.1038/s41401-025-01633-4
	9JED (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		2.58	2025-09-10	doi.org/10.1038/s41401-025-01633-4
	9L42	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.9	2025-10-22	doi.org/10.3390/ph18030292
	9L42 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.9	2025-10-22	doi.org/10.3390/ph18030292
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	doi.org/10.1038/s41467-024-46840-5
	9LRC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	-	2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9LRE	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9LRE (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.84	2025-06-11	doi.org/10.1038/s42003-025-08363-7
	9JG1	A	Amine	Histamine	H₄	Homo sapiens	Adriforant	-	-	3.62	2025-12-03	10.1038/s41401-025-01633-4
	9JG1 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Adriforant	-		3.62	2025-12-03	10.1038/s41401-025-01633-4

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