psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D94	11.5	Yes	Yes	1	0	8
2	L:L:?1	R:R:Y95	16.55	Yes	Yes	0	0	8
3	L:L:?1	R:R:C98	7.47	Yes	No	1	0	8
4	L:L:?1	R:R:Y319	7.72	Yes	Yes	1	0	7
5	L:L:?1	R:R:F344	28.66	Yes	Yes	1	0	6
6	L:L:?1	R:R:Q347	25.05	Yes	No	1	0	8
7	L:L:?1	R:R:W348	13.93	Yes	Yes	1	0	8
8	R:R:S11	R:R:T14	6.4	No	No	0	7	5
9	R:R:L18	R:R:L77	4.15	No	No	0	5	6
10	R:R:F20	R:R:F21	4.29	No	No	0	4	4
11	R:R:I73	R:R:M22	8.75	No	No	0	6	7
12	R:R:L77	R:R:M22	7.07	No	No	0	6	7
13	R:R:M22	R:R:W345	10.47	No	No	0	7	8
14	R:R:F349	R:R:V25	6.55	No	No	0	4	7
15	R:R:A26	R:R:I69	4.87	No	Yes	0	7	8
16	R:R:F27	R:R:L31	4.87	No	No	0	5	4
17	R:R:M30	R:R:V66	6.09	No	No	0	6	5
18	R:R:D61	R:R:N33	6.73	Yes	No	0	9	9
19	R:R:N33	R:R:P355	13.03	No	No	0	9	9
20	R:R:P359	R:R:V36	7.07	No	No	0	8	9
21	R:R:F365	R:R:V36	3.93	Yes	No	0	8	9
22	R:R:I37	R:R:L55	4.28	No	No	0	8	7
23	R:R:I372	R:R:L38	4.28	Yes	No	0	6	4
24	R:R:A39	R:R:F369	4.16	No	No	0	8	8
25	R:R:F40	R:R:R47	22.45	No	No	6	8	8
26	R:R:F40	R:R:Y52	7.22	No	Yes	6	8	6
27	R:R:F40	R:R:L55	19.49	No	No	0	8	7
28	R:R:D43	R:R:N45	6.73	No	No	0	7	6
29	R:R:D43	R:R:L46	10.86	No	No	0	7	9
30	R:R:A368	R:R:D43	4.63	No	No	0	8	7
31	R:R:K44	R:R:R47	3.71	No	No	0	7	8
32	R:R:L46	R:R:S51	4.5	No	No	5	9	9
33	R:R:F365	R:R:L46	12.18	Yes	No	5	8	9
34	R:R:R47	R:R:Y52	8.23	No	Yes	6	8	6
35	R:R:H48	R:R:R364	28.21	No	No	0	7	7
36	R:R:F53	R:R:R49	5.34	Yes	Yes	3	8	7
37	R:R:D111	R:R:R49	13.1	Yes	Yes	3	9	7
38	R:R:R49	R:R:Y122	7.2	Yes	No	3	7	8
39	R:R:Q125	R:R:R49	7.01	No	Yes	3	5	7
40	R:R:R49	R:R:T127	14.23	Yes	Yes	3	7	8
41	R:R:D111	R:R:S50	4.42	Yes	No	0	9	8
42	R:R:F365	R:R:S51	3.96	Yes	No	5	8	9
43	R:R:I132	R:R:Y52	7.25	No	Yes	0	7	6
44	R:R:M136	R:R:Y52	3.59	No	Yes	0	8	6
45	R:R:F53	R:R:L107	19.49	Yes	No	0	8	8
46	R:R:D111	R:R:F53	9.55	Yes	Yes	3	9	8
47	R:R:F53	R:R:L135	3.65	Yes	No	0	8	7
48	R:R:F54	R:R:I108	6.28	Yes	No	0	8	9
49	R:R:F54	R:R:P359	5.78	Yes	No	0	8	8
50	R:R:F54	R:R:H362	5.66	Yes	No	0	8	9
51	R:R:F365	R:R:F54	8.57	Yes	Yes	0	8	8
52	R:R:I59	R:R:L55	4.28	No	No	0	6	7
53	R:R:N104	R:R:N56	14.98	No	Yes	2	8	9
54	R:R:M136	R:R:N56	14.02	No	Yes	0	8	9
55	R:R:N56	R:R:V139	4.43	Yes	No	2	9	8
56	R:R:N56	R:R:W140	11.3	Yes	No	0	9	9
57	R:R:D61	R:R:L57	4.07	Yes	Yes	2	9	9
58	R:R:L57	R:R:N104	9.61	Yes	No	2	9	8
59	R:R:I105	R:R:L57	5.71	No	Yes	2	9	9
60	R:R:I108	R:R:L57	4.28	No	Yes	0	9	9
61	R:R:L57	R:R:N354	8.24	Yes	Yes	2	9	9
62	R:R:S101	R:R:S60	4.89	No	No	0	9	9
63	R:R:D61	R:R:S101	10.31	Yes	No	0	9	9
64	R:R:D61	R:R:S351	10.31	Yes	No	0	9	9
65	R:R:D61	R:R:N354	8.08	Yes	Yes	2	9	9
66	R:R:F62	R:R:F63	8.57	No	No	0	8	6
67	R:R:F62	R:R:V66	7.87	No	No	0	8	5
68	R:R:F63	R:R:I67	3.77	No	No	0	6	6
69	R:R:F63	R:R:L97	3.65	No	No	0	6	6
70	R:R:V64	R:R:W348	3.68	No	Yes	0	8	8
71	R:R:S351	R:R:V64	9.7	No	No	0	9	8
72	R:R:G65	R:R:I69	5.29	No	Yes	0	8	8
73	R:R:D94	R:R:S68	8.83	Yes	No	1	8	8
74	R:R:S68	R:R:W348	3.71	No	Yes	1	8	8
75	R:R:I69	R:R:W348	14.09	Yes	Yes	0	8	8
76	R:R:L71	R:R:W90	6.83	No	Yes	0	5	7
77	R:R:T76	R:R:Y72	18.73	No	Yes	0	5	7
78	R:R:W90	R:R:Y72	7.72	Yes	Yes	0	7	7
79	R:R:F344	R:R:Y72	8.25	Yes	Yes	1	6	7
80	R:R:W345	R:R:Y72	4.82	No	Yes	1	8	7
81	R:R:W348	R:R:Y72	8.68	Yes	Yes	1	8	7
82	R:R:P74	R:R:W80	5.4	No	No	0	5	9
83	R:R:F82	R:R:H75	29.41	Yes	No	0	6	6
84	R:R:F78	R:R:L77	3.65	No	No	0	5	6
85	R:R:F82	R:R:W80	8.02	Yes	No	0	6	9
86	R:R:C87	R:R:F82	4.19	No	Yes	7	9	6
87	R:R:F82	R:R:W90	5.01	Yes	Yes	0	6	7
88	R:R:C164	R:R:F82	4.19	No	Yes	7	9	6
89	R:R:C164	R:R:C87	7.28	No	No	7	9	9
90	R:R:E155	R:R:V88	4.28	No	No	0	6	7
91	R:R:L91	R:R:W90	4.56	No	Yes	0	6	7
92	R:R:C164	R:R:L91	4.76	No	No	0	9	6
93	R:R:C98	R:R:D94	4.67	No	Yes	1	8	8
94	R:R:D94	R:R:W348	11.17	Yes	Yes	1	8	8
95	R:R:N147	R:R:Y95	10.47	Yes	Yes	0	8	8
96	R:R:I151	R:R:Y95	6.04	No	Yes	0	7	8
97	R:R:P166	R:R:Y95	9.74	No	Yes	0	7	8
98	R:R:L96	R:R:W140	5.69	No	No	0	6	9
99	R:R:T99	R:R:Y103	6.24	Yes	No	0	8	7
100	R:R:N147	R:R:T99	4.39	Yes	Yes	1	8	8
101	R:R:E182	R:R:T99	4.23	No	Yes	1	8	8
102	R:R:A100	R:R:W140	5.19	No	No	0	8	9
103	R:R:F312	R:R:V102	7.87	No	No	1	9	8
104	R:R:V102	R:R:W316	8.58	No	Yes	1	8	9
105	R:R:V146	R:R:Y103	6.31	No	No	0	7	7
106	R:R:N104	R:R:V139	7.39	No	No	2	8	8
107	R:R:I105	R:R:N354	5.66	No	Yes	2	9	9
108	R:R:I105	R:R:Y358	9.67	No	Yes	2	9	9
109	R:R:I108	R:R:R112	3.76	No	No	0	9	9
110	R:R:S109	R:R:V190	4.85	No	No	0	9	9
111	R:R:L114	R:R:Y110	14.07	No	No	0	5	6
112	R:R:F193	R:R:Y110	10.32	No	No	0	7	6
113	R:R:D111	R:R:Y122	11.49	Yes	No	3	9	8
114	R:R:R112	R:R:Y358	7.2	No	Yes	0	9	9
115	R:R:S117	R:R:Y113	10.17	No	No	0	7	9
116	R:R:F193	R:R:Y113	11.35	No	No	0	7	9
117	R:R:N196	R:R:Y113	6.98	No	No	0	6	9
118	R:R:S115	R:R:Y122	8.9	No	No	0	8	8
119	R:R:S200	R:R:V116	8.08	No	No	0	6	8
120	R:R:N118	R:R:S121	7.45	No	No	0	6	5
121	R:R:Q125	R:R:T127	5.67	No	Yes	3	5	8
122	R:R:I132	R:R:T127	6.08	No	Yes	0	7	8
123	R:R:F144	R:R:G148	7.53	No	No	8	5	5
124	R:R:F144	R:R:P149	7.22	No	No	8	5	8
125	R:R:N147	R:R:V146	7.39	Yes	No	0	8	7
126	R:R:N147	R:R:T178	4.39	Yes	No	0	8	8
127	R:R:E182	R:R:N147	9.2	No	Yes	1	8	8
128	R:R:G148	R:R:P149	4.06	No	No	8	5	8
129	R:R:F168	R:R:M150	6.22	Yes	No	4	6	7
130	R:R:I174	R:R:M150	5.83	Yes	No	4	8	7
131	R:R:S154	R:R:W157	8.65	No	No	0	8	6
132	R:R:G167	R:R:S154	3.71	No	No	0	6	8
133	R:R:F168	R:R:S154	7.93	Yes	No	0	6	8
134	R:R:K158	R:R:S162	6.12	No	No	0	6	3
135	R:R:G167	R:R:K158	5.23	No	No	0	6	6
136	R:R:E163	R:R:E165	3.81	No	No	0	4	4
137	R:R:E163	R:R:K336	4.05	No	No	0	4	4
138	R:R:E165	R:R:F169	10.49	No	Yes	0	4	6
139	R:R:E165	R:R:T333	5.64	No	No	0	4	6
140	R:R:F168	R:R:P166	8.67	Yes	No	0	6	7
141	R:R:F169	R:R:P166	14.45	Yes	No	0	6	7
142	R:R:F168	R:R:I174	6.28	Yes	Yes	4	6	8
143	R:R:F168	R:R:L175	4.87	Yes	Yes	0	6	7
144	R:R:F169	R:R:L175	8.53	Yes	Yes	0	6	7
145	R:R:E171	R:R:S170	7.19	No	No	0	6	3
146	R:R:E171	R:R:Y173	13.47	No	No	4	6	4
147	R:R:E171	R:R:I174	5.47	No	Yes	4	6	8
148	R:R:F328	R:R:W172	13.03	No	No	0	5	4
149	R:R:I174	R:R:Y173	9.67	Yes	No	4	8	4
150	R:R:L175	R:R:T323	4.42	Yes	No	0	7	7
151	R:R:S179	R:R:S320	4.89	No	No	0	8	8
152	R:R:F180	R:R:V184	7.87	No	No	0	4	7
153	R:R:F180	R:R:I185	7.54	No	No	0	4	6
154	R:R:E182	R:R:W316	9.81	No	Yes	1	8	9
155	R:R:F183	R:R:V187	3.93	Yes	No	0	9	6
156	R:R:F183	R:R:W316	4.01	Yes	Yes	0	9	9
157	R:R:A317	R:R:F183	4.16	No	Yes	0	7	9
158	R:R:F183	R:R:S320	7.93	Yes	No	0	9	8
159	R:R:F312	R:R:V187	5.24	No	No	0	9	6
160	R:R:N194	R:R:V190	4.43	No	No	0	9	9
161	R:R:F193	R:R:Y192	5.16	No	No	0	7	5
162	R:R:N196	R:R:Y192	16.28	No	No	0	6	5
163	R:R:L305	R:R:N194	10.98	No	No	0	8	9
164	R:R:M195	R:R:W199	10.47	No	No	0	3	4
165	R:R:N196	R:R:W199	4.52	No	No	0	6	4
166	R:R:I197	R:R:L305	4.28	No	No	0	9	8
167	R:R:W202	R:R:Y198	5.79	No	No	0	6	7
168	R:R:A302	R:R:Y198	4	No	No	0	7	7
169	R:R:L201	R:R:W202	7.97	No	No	0	8	6
170	R:R:L201	R:R:L301	4.15	No	No	0	8	8
171	R:R:E291	R:R:E294	7.61	No	No	0	5	5
172	R:R:L295	R:R:R299	3.64	No	No	0	4	6
173	R:R:L301	R:R:L305	6.92	No	No	0	8	8
174	R:R:L308	R:R:L357	5.54	No	No	2	8	8
175	R:R:L308	R:R:Y358	9.38	No	Yes	2	8	9
176	R:R:L357	R:R:V311	4.47	No	No	0	8	6
177	R:R:F312	R:R:W316	6.01	No	Yes	1	9	9
178	R:R:C315	R:R:N350	7.87	No	No	0	8	9
179	R:R:Q347	R:R:W316	26.29	No	Yes	1	8	9
180	R:R:N350	R:R:W316	4.52	No	Yes	0	9	9
181	R:R:T323	R:R:Y319	8.74	No	Yes	1	7	7
182	R:R:Y319	R:R:Y340	10.92	Yes	Yes	1	7	5
183	R:R:F344	R:R:Y319	10.32	Yes	Yes	1	6	7
184	R:R:Q347	R:R:Y319	6.76	No	Yes	1	8	7
185	R:R:F322	R:R:L326	7.31	No	No	0	6	5
186	R:R:F322	R:R:Y340	10.32	No	Yes	0	6	5
187	R:R:T323	R:R:Y340	3.75	No	Yes	1	7	5
188	R:R:F328	R:R:Y329	5.16	No	No	0	5	5
189	R:R:G334	R:R:P335	4.06	No	No	0	1	4
190	R:R:K336	R:R:Y340	20.3	No	Yes	0	4	5
191	R:R:K336	R:R:R341	6.19	No	No	0	4	6
192	R:R:F344	R:R:W348	8.02	Yes	Yes	1	6	8
193	R:R:W345	R:R:W348	9.37	No	Yes	1	8	8
194	R:R:N350	R:R:N354	12.26	No	Yes	0	9	9
195	R:R:L357	R:R:Y358	4.69	No	Yes	2	8	9
196	R:R:H362	R:R:R364	15.8	No	No	0	9	7
197	R:R:G65	R:R:I29	3.53	No	No	0	8	8
198	R:R:P186	R:R:V102	3.53	No	No	0	9	8
199	R:R:P186	R:R:V106	3.53	No	No	0	9	7
200	R:R:A58	R:R:V36	3.39	No	No	0	9	9
201	R:R:I69	R:R:P70	3.39	Yes	No	0	8	9
202	R:R:I185	R:R:P186	3.39	No	No	0	6	9
203	R:R:A143	R:R:T99	3.36	No	Yes	0	8	8
204	R:R:F365	R:R:F369	3.22	Yes	No	0	8	8
205	R:R:G128	R:R:H126	3.18	No	No	0	4	7
206	R:R:A191	R:R:L309	3.15	No	No	0	5	8
207	R:R:I73	R:R:S23	3.1	No	No	0	6	5
208	R:R:I324	R:R:S179	3.1	No	No	0	6	8
209	R:R:I29	R:R:V25	3.07	No	No	0	8	7
210	R:R:I372	R:R:V42	3.07	Yes	No	0	6	6
211	R:R:I197	R:R:V116	3.07	No	No	0	9	8
212	R:R:I342	R:R:V338	3.07	No	No	0	5	1
213	R:R:I151	R:R:T92	3.04	No	No	0	7	6
214	R:R:K131	R:R:T127	3	No	Yes	0	7	8
215	R:R:L175	R:R:S327	3	Yes	No	0	7	6
216	R:R:L326	R:R:S331	3	No	No	0	5	3
217	R:R:L12	R:R:V16	2.98	No	No	0	3	5
218	R:R:L97	R:R:V64	2.98	No	No	0	6	8
219	R:R:L189	R:R:V106	2.98	No	No	0	7	7
220	R:R:L181	R:R:V146	2.98	No	No	0	5	7
221	R:R:L309	R:R:V190	2.98	No	No	0	8	9
222	R:R:L97	R:R:T93	2.95	No	No	0	6	5
223	R:R:I307	R:R:K303	2.91	No	No	0	7	7
224	R:R:W199	R:R:Y198	2.89	No	No	0	4	7
225	R:R:A19	R:R:F78	2.77	No	No	0	5	5
226	R:R:A28	R:R:F352	2.77	No	Yes	0	4	6
227	R:R:A34	R:R:F62	2.77	No	No	0	4	8
228	R:R:A332	R:R:F169	2.77	No	Yes	0	1	6
229	R:R:L356	R:R:L360	2.77	No	No	0	6	6
230	R:R:L308	R:R:N194	2.75	No	No	0	8	9
231	R:R:E155	R:R:K158	2.7	No	No	0	6	6
232	R:R:F352	R:R:V353	2.62	Yes	No	0	6	7
233	R:R:F89	R:R:T93	2.59	No	No	0	4	5
234	R:R:F144	R:R:T92	2.59	No	No	0	5	6
235	R:R:A176	R:R:W172	2.59	No	No	0	6	4
236	R:R:V325	R:R:Y329	2.52	No	No	0	6	5
237	R:R:F352	R:R:I29	2.51	Yes	No	0	6	8
238	R:R:F82	R:R:I86	2.51	Yes	No	0	6	5
239	R:R:F373	R:R:I372	2.51	No	Yes	0	7	6
240	R:R:F27	R:R:M30	2.49	No	No	0	5	6
241	R:R:S156	R:R:W157	2.47	No	No	0	5	6
242	R:R:S327	R:R:W172	2.47	No	No	0	6	4
243	R:R:S337	R:R:W339	2.47	No	No	0	2	5
244	R:R:F373	R:R:L35	2.44	No	No	0	7	8
245	R:R:F352	R:R:L356	2.44	Yes	No	0	6	6
246	R:R:F369	R:R:L360	2.44	No	No	0	8	6
247	R:R:L12	R:R:R15	2.43	No	No	0	3	3
248	R:R:L296	R:R:R300	2.43	No	No	0	4	8
249	R:R:I342	R:R:W339	2.35	No	No	0	5	5
250	R:R:L142	R:R:Y103	2.34	No	No	0	5	7
251	R:R:E294	R:R:R297	2.33	No	No	0	5	7
252	R:R:F78	R:R:R15	2.14	No	No	0	5	3
253	R:R:R297	R:R:R300	2.13	No	No	0	7	8
254	R:R:A317	R:R:P318	1.87	No	No	0	7	9
255	R:R:A343	R:R:P318	1.87	No	No	0	5	9
256	R:R:G334	R:R:T333	1.82	No	No	0	1	6
257	R:R:G32	R:R:L31	1.71	No	No	0	8	4
258	R:R:G310	R:R:L309	1.71	No	No	0	6	8
259	R:R:L145	R:R:P149	1.64	No	No	0	4	8
260	R:R:L346	R:R:P318	1.64	No	No	0	8	9
261	R:R:A39	R:R:I372	1.62	No	Yes	0	8	6
262	R:R:V129	R:R:V133	1.6	No	No	0	4	3
263	R:R:V133	R:R:V137	1.6	No	No	0	3	4
264	R:R:V137	R:R:V141	1.6	No	No	0	4	4
265	R:R:T124	R:R:V120	1.59	No	No	0	5	7
266	R:R:A298	R:R:L201	1.58	No	No	0	8	8
267	R:R:T14	R:R:T17	1.57	No	No	0	5	3
268	R:R:I188	R:R:V184	1.54	No	No	0	4	7
269	R:R:I307	R:R:V311	1.54	No	No	0	7	6
270	R:R:L152	R:R:V88	1.49	No	No	0	5	7
271	R:R:L145	R:R:V141	1.49	No	No	0	4	4
272	R:R:N118	R:R:V120	1.48	No	No	0	6	7
273	R:R:L18	R:R:T17	1.47	No	No	0	5	3
274	R:R:K363	R:R:K367	1.44	No	No	0	5	5
275	R:R:E294	R:R:V293	1.43	No	No	0	5	5
276	R:R:K363	R:R:Q366	1.36	No	No	0	5	9
277	R:R:E160	R:R:K84	1.35	No	No	0	3	3
278	R:R:S337	R:R:Y340	1.27	No	Yes	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	15.84	7	1	0
2	R:R:R49	9.376	5	3	7
3	R:R:Y52	6.5725	4	6	6
4	R:R:F53	9.5075	4	3	8
5	R:R:F54	6.5725	4	0	8
6	R:R:N56	11.1825	4	2	9
7	R:R:L57	6.382	5	2	9
8	R:R:D61	7.9	5	2	9
9	R:R:I69	6.91	4	0	8
10	R:R:Y72	9.64	5	1	7
11	R:R:F82	8.88833	6	7	6
12	R:R:W90	6.03	4	0	7
13	R:R:D94	9.0425	4	1	8
14	R:R:Y95	10.7	4	0	8
15	R:R:T99	4.555	4	1	8
16	R:R:D111	9.64	4	3	9
17	R:R:T127	7.245	4	3	8
18	R:R:N147	7.168	5	1	8
19	R:R:F168	6.794	5	4	6
20	R:R:F169	9.06	4	0	6
21	R:R:I174	6.8125	4	4	8
22	R:R:L175	5.205	4	0	7
23	R:R:F183	5.0075	4	0	9
24	R:R:W316	9.87	6	1	9
25	R:R:Y319	8.892	5	1	7
26	R:R:Y340	9.312	5	1	5
27	R:R:F344	13.8125	4	1	6
28	R:R:W348	9.08125	8	1	8
29	R:R:F352	2.585	4	0	6
30	R:R:N354	8.56	4	2	9
31	R:R:Y358	7.735	4	2	9
32	R:R:F365	6.372	5	5	8
33	R:R:I372	2.87	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W348	53.3769	13.93	Yes	Yes	1	0	8
2	R:R:W345	R:R:W348	29.1955	9.37	No	Yes	1	8	8
3	R:R:M22	R:R:W345	30.6203	10.47	No	No	0	7	8
4	R:R:L77	R:R:M22	23.9059	7.07	No	No	0	6	7
5	R:R:I69	R:R:W348	26.3539	14.09	Yes	Yes	0	8	8
6	R:R:G65	R:R:I69	20.6943	5.29	No	Yes	0	8	8
7	R:R:G65	R:R:I29	18.8445	3.53	No	No	0	8	8
8	R:R:V64	R:R:W348	66.5617	3.68	No	Yes	0	8	8
9	R:R:L97	R:R:V64	26.7239	2.98	No	No	0	6	8
10	R:R:F63	R:R:L97	20.2535	3.65	No	No	0	6	6
11	R:R:F62	R:R:F63	15.8611	8.57	No	No	0	8	6
12	R:R:F62	R:R:V66	11.4059	7.87	No	No	0	8	5
13	R:R:S351	R:R:V64	64.3105	9.7	No	No	0	9	8
14	R:R:D61	R:R:S351	64.4128	10.31	Yes	No	0	9	9
15	L:L:?1	R:R:Q347	41.9002	25.05	Yes	No	1	0	8
16	R:R:Q347	R:R:W316	83.6429	26.29	No	Yes	1	8	9
17	R:R:N350	R:R:W316	100	4.52	No	Yes	0	9	9
18	R:R:N350	R:R:N354	98.3785	12.26	No	Yes	0	9	9
19	R:R:L57	R:R:N354	53.4713	8.24	Yes	Yes	2	9	9
20	R:R:I108	R:R:L57	41.5696	4.28	No	Yes	0	9	9
21	R:R:F54	R:R:I108	45.9855	6.28	Yes	No	0	8	9
22	R:R:D61	R:R:L57	47.7015	4.07	Yes	Yes	2	9	9
23	R:R:F365	R:R:F54	30.5888	8.57	Yes	Yes	0	8	8
24	R:R:L57	R:R:N104	61.6105	9.61	Yes	No	2	9	8
25	R:R:N104	R:R:N56	57.0135	14.98	No	Yes	2	8	9
26	R:R:M136	R:R:N56	48.1974	14.02	No	Yes	0	8	9
27	R:R:M136	R:R:Y52	45.9068	3.59	No	Yes	0	8	6
28	R:R:F40	R:R:Y52	10.0047	7.22	No	Yes	6	8	6
29	R:R:F352	R:R:I29	14.0979	2.51	Yes	No	0	6	8
30	R:R:F352	R:R:L356	12.1851	2.44	Yes	No	0	6	6
31	R:R:L356	R:R:L360	11.6341	2.77	No	No	0	6	6
32	R:R:F369	R:R:L360	11.4531	2.44	No	No	0	8	6
33	R:R:A39	R:R:F369	12.744	4.16	No	No	0	8	8
34	R:R:A39	R:R:I372	10.6581	1.62	No	Yes	0	8	6
35	R:R:F365	R:R:L46	10.1936	12.18	Yes	No	5	8	9
36	R:R:I132	R:R:Y52	29.5419	7.25	No	Yes	0	7	6
37	R:R:I132	R:R:T127	27.1332	6.08	No	Yes	0	7	8
38	R:R:R49	R:R:T127	19.8756	14.23	Yes	Yes	3	7	8
39	R:R:I105	R:R:N354	57.5409	5.66	No	Yes	2	9	9
40	R:R:F344	R:R:Y72	16.5302	8.25	Yes	Yes	1	6	7
41	R:R:W90	R:R:Y72	32.7535	7.72	Yes	Yes	0	7	7
42	R:R:W348	R:R:Y72	22.7645	8.68	Yes	Yes	1	8	7
43	R:R:F82	R:R:W90	21.2453	5.01	Yes	Yes	0	6	7
44	R:R:F78	R:R:L77	12.2324	3.65	No	No	0	5	6
45	L:L:?1	R:R:Y95	68.4588	16.55	Yes	Yes	0	0	8
46	R:R:P166	R:R:Y95	64.3341	9.74	No	Yes	0	7	8
47	R:R:F168	R:R:P166	44.545	8.67	Yes	No	0	6	7
48	R:R:F168	R:R:S154	36.5475	7.93	Yes	No	0	6	8
49	R:R:G167	R:R:S154	24.5041	3.71	No	No	0	6	8
50	R:R:G167	R:R:K158	20.4581	5.23	No	No	0	6	6
51	R:R:E155	R:R:K158	12.319	2.7	No	No	0	6	6
52	R:R:N147	R:R:Y95	37.9959	10.47	Yes	Yes	0	8	8
53	R:R:I151	R:R:Y95	30.9115	6.04	No	Yes	0	7	8
54	R:R:E182	R:R:N147	31.1792	9.2	No	Yes	1	8	8
55	R:R:E182	R:R:W316	36.0595	9.81	No	Yes	1	8	9
56	R:R:V102	R:R:W316	19.6395	8.58	No	Yes	1	8	9
57	R:R:I105	R:R:Y358	78.3139	9.67	No	Yes	2	9	9
58	R:R:I108	R:R:R112	10.3826	3.76	No	No	0	9	9
59	R:R:L308	R:R:Y358	73.2132	9.38	No	Yes	2	8	9
60	R:R:L308	R:R:N194	71.7648	2.75	No	No	0	8	9
61	R:R:N194	R:R:V190	13.846	4.43	No	No	0	9	9
62	R:R:L305	R:R:N194	57.2654	10.98	No	No	0	8	9
63	R:R:L301	R:R:L305	47.2528	6.92	No	No	0	8	8
64	R:R:L201	R:R:L301	44.8914	4.15	No	No	0	8	8
65	R:R:L201	R:R:W202	40.1685	7.97	No	No	0	8	6
66	R:R:W202	R:R:Y198	37.5866	5.79	No	No	0	6	7
67	R:R:W199	R:R:Y198	32.3835	2.89	No	No	0	4	7
68	R:R:N196	R:R:W199	27.1096	4.52	No	No	0	6	4
69	R:R:N196	R:R:Y113	13.7043	6.98	No	No	0	6	9
70	R:R:F193	R:R:Y110	10.8155	10.32	No	No	0	7	6
71	R:R:N196	R:R:Y192	10.7683	16.28	No	No	0	6	5
72	R:R:I151	R:R:T92	28.188	3.04	No	No	0	7	6
73	R:R:F144	R:R:T92	25.1181	2.59	No	No	0	5	6
74	R:R:F144	R:R:P149	18.8838	7.22	No	No	8	5	8
75	R:R:F168	R:R:I174	16.3649	6.28	Yes	Yes	4	6	8
76	L:L:?1	R:R:Y319	11.1461	7.72	Yes	Yes	1	0	7
77	R:R:Y319	R:R:Y340	27.9203	10.92	Yes	Yes	1	7	5
78	R:R:K336	R:R:Y340	10.847	20.3	No	Yes	0	4	5
79	R:R:F169	R:R:P166	19.3089	14.45	Yes	No	0	6	7
80	R:R:E165	R:R:F169	16.8372	10.49	No	Yes	0	4	6
81	R:R:E165	R:R:T333	15.318	5.64	No	No	0	4	6
82	R:R:T323	R:R:Y319	36.1067	8.74	No	Yes	1	7	7
83	R:R:L175	R:R:T323	36.0989	4.42	Yes	No	0	7	7
84	R:R:L175	R:R:S327	15.9556	3	Yes	No	0	7	6
85	R:R:S327	R:R:W172	13.3344	2.47	No	No	0	6	4
86	R:R:F183	R:R:W316	22.0954	4.01	Yes	Yes	0	9	9
87	R:R:P186	R:R:V102	17.3489	3.53	No	No	0	9	8
88	R:R:I185	R:R:P186	10.0047	3.39	No	No	0	6	9
89	R:R:A317	R:R:F183	10.0362	4.16	No	Yes	0	7	9
90	R:R:L357	R:R:Y358	10.1779	4.69	No	Yes	2	8	9
91	R:R:G334	R:R:T333	10.2251	1.82	No	No	0	1	6
92	R:R:S337	R:R:Y340	10.1307	1.27	No	Yes	0	2	5
93	R:R:L145	R:R:P149	15.8139	1.64	No	No	0	4	8
94	R:R:L145	R:R:V141	12.681	1.49	No	No	0	4	4
95	R:R:D61	R:R:N354	18.4745	8.08	Yes	Yes	2	9	9
96	R:R:I105	R:R:L57	23.0085	5.71	No	Yes	2	9	9
97	R:R:F168	R:R:L175	18.3328	4.87	Yes	Yes	0	6	7
98	R:R:F344	R:R:Y319	18.5217	10.32	Yes	Yes	1	6	7
99	R:R:Q347	R:R:Y319	42.0891	6.76	No	Yes	1	8	7
100	R:R:F365	R:R:F369	13.1612	3.22	Yes	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D94	11.5	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y95	16.55	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:C98	7.47	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y319	7.72	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F344	28.66	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q347	25.05	1	Yes	No	0	8	0	1
L:L:?1	R:R:W348	13.93	1	Yes	Yes	0	8	0	1
R:R:V64	R:R:W348	3.68	0	No	Yes	8	8	2	1
R:R:D94	R:R:S68	8.83	1	Yes	No	8	8	1	2
R:R:S68	R:R:W348	3.71	1	No	Yes	8	8	2	1
R:R:I69	R:R:W348	14.09	0	Yes	Yes	8	8	2	1
R:R:F344	R:R:Y72	8.25	1	Yes	Yes	6	7	1	2
R:R:W345	R:R:Y72	4.82	1	No	Yes	8	7	2	2
R:R:W348	R:R:Y72	8.68	1	Yes	Yes	8	7	1	2
R:R:C98	R:R:D94	4.67	1	No	Yes	8	8	1	1
R:R:D94	R:R:W348	11.17	1	Yes	Yes	8	8	1	1
R:R:N147	R:R:Y95	10.47	1	Yes	Yes	8	8	2	1
R:R:I151	R:R:Y95	6.04	0	No	Yes	7	8	2	1
R:R:P166	R:R:Y95	9.74	0	No	Yes	7	8	2	1
R:R:Q347	R:R:W316	26.29	1	No	Yes	8	9	1	2
R:R:T323	R:R:Y319	8.74	1	No	Yes	7	7	2	1
R:R:Y319	R:R:Y340	10.92	1	Yes	Yes	7	5	1	2
R:R:F344	R:R:Y319	10.32	1	Yes	Yes	6	7	1	1
R:R:Q347	R:R:Y319	6.76	1	No	Yes	8	7	1	1
R:R:T323	R:R:Y340	3.75	1	No	Yes	7	5	2	2
R:R:F344	R:R:W348	8.02	1	Yes	Yes	6	8	1	1
R:R:W345	R:R:W348	9.37	1	No	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YN9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	250
Number of Links	278
Number of Hubs	33
Number of Links mediated by Hubs	124
Number of Communities	8
Number of Nodes involved in Communities	51
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	41007
Length Of Smallest Path	3
Average Path Length	12.6389
Length of Longest Path	30
Minimum Path Strength	1.4
Average Path Strength	8.08536
Maximum Path Strength	26.855
Minimum Path Correlation	0.7
Average Path Correlation	0.924528
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	54.9883
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.2652
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • regulation of intracellular signal transduction • regulation of response to stimulus • MAPK cascade • regulation of cell communication • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	4-imidazoleethylamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H3N8
Sequence	>8YN9_nogp_Chain_R S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D K N L R H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L F E W D F G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N A V S Y R T Q H T G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K D E G S E C E P G F F S E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W E H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S S A T G P K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F Q K A F L K I F C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ	2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YN9	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN9 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		2.3	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	10.1038/s41589-024-01620-6
	8JXX	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-	Gi1/β1/γ2	3.06	2024-03-20	10.1038/s41467-024-46840-5
	8JXX (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clobenpropit	-		3.06	2024-03-20	10.1038/s41467-024-46840-5
	8JXW	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-	Gi1/β1/γ2	3.01	2024-03-20	10.1038/s41467-024-46840-5
	8JXW (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	VUF6884	-		3.01	2024-03-20	10.1038/s41467-024-46840-5
	8JXV	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-	Gi1/β1/γ2	3.21	2024-03-20	10.1038/s41467-024-46840-5
	8JXV (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Clozapine	-		3.21	2024-03-20	10.1038/s41467-024-46840-5
	8JXT	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4	Gi1/β1/γ2	3.07	2024-03-20	10.1038/s41467-024-46840-5
	8JXT (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	PO4		3.07	2024-03-20	10.1038/s41467-024-46840-5
	8HOC	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HOC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3	2023-12-20	To be published
	8HN8	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	Gi1/β1/γ2	3	2023-12-20	To be published
	8HN8 (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-12-20	To be published
	7YFD	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-10-25	10.1038/s41467-023-42260-z
	7YFD (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Imetit	-		3.1	2023-10-25	10.1038/s41467-023-42260-z
	7YFC	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-10-25	10.1038/s41467-023-42260-z
	7YFC (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Histamine	-		3	2023-10-25	10.1038/s41467-023-42260-z
	8H4L	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4L (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.07	2023-06-21	10.1038/s41422-023-00835-x
	8H4K	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4K (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	GW9508	-		3.1	2023-06-21	10.1038/s41422-023-00835-x
	8H4I	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-	chim(NtGi1-Gs)/β1/γ2	3.06	2023-06-21	10.1038/s41422-023-00835-x
	8H4I (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Doconexent	-		3.06	2023-06-21	10.1038/s41422-023-00835-x
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	10.1038/s41467-023-41654-3
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WH4 (Multimeric)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-		3.4	2020-09-23	10.1016/j.cell.2020.08.024

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