psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D114	6.9	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y115	11.92	Yes	Yes	1	0	9
3	L:L:?1	R:R:C118	5.38	Yes	No	0	0	8
4	L:L:?1	R:R:E206	6.74	Yes	Yes	0	0	8
5	L:L:?1	R:R:Y374	13.25	Yes	Yes	1	0	9
6	L:L:?1	R:R:F398	17.2	Yes	Yes	1	0	7
7	L:L:?1	R:R:L401	10.17	Yes	No	1	0	8
8	L:L:?1	R:R:W402	8.37	Yes	Yes	1	0	8
9	R:R:L37	R:R:M41	4.24	No	No	0	5	7
10	R:R:M41	R:R:V92	7.61	No	No	0	7	7
11	R:R:M41	R:R:W399	8.14	No	No	0	7	9
12	R:R:I45	R:R:I88	4.42	No	No	0	7	9
13	R:R:I45	R:R:P89	10.16	No	No	0	7	9
14	R:R:G84	R:R:T48	3.64	No	No	0	9	9
15	R:R:F81	R:R:V49	3.93	Yes	No	0	8	7
16	R:R:D80	R:R:N52	6.73	Yes	No	0	9	9
17	R:R:N52	R:R:P409	11.4	No	No	0	9	9
18	R:R:F423	R:R:L54	17.05	Yes	No	0	9	8
19	R:R:A77	R:R:V55	5.09	No	No	0	9	9
20	R:R:P413	R:R:V55	8.84	No	No	0	9	9
21	R:R:F81	R:R:M56	12.44	Yes	No	0	8	7
22	R:R:F59	R:R:R66	17.1	No	No	3	8	8
23	R:R:F59	R:R:F71	9.65	No	Yes	3	8	6
24	R:R:F59	R:R:L74	17.05	No	No	0	8	8
25	R:R:A61	R:R:L426	4.73	No	No	0	7	8
26	R:R:D62	R:R:S64	10.31	No	No	0	8	7
27	R:R:D62	R:R:L65	10.86	No	No	0	8	9
28	R:R:L65	R:R:N70	9.61	No	No	2	9	9
29	R:R:F419	R:R:L65	4.87	Yes	No	2	9	9
30	R:R:F71	R:R:R66	5.34	Yes	No	3	6	8
31	R:R:N70	R:R:T67	10.24	No	No	0	9	8
32	R:R:Q146	R:R:T67	9.92	No	No	0	8	8
33	R:R:Q68	R:R:R151	5.84	No	No	0	8	7
34	R:R:L73	R:R:N69	5.49	Yes	No	2	8	8
35	R:R:D131	R:R:N69	12.12	No	No	0	9	8
36	R:R:H416	R:R:N69	6.38	Yes	No	2	9	8
37	R:R:F419	R:R:N70	7.25	Yes	No	2	9	9
38	R:R:F71	R:R:T149	5.19	Yes	No	0	6	6
39	R:R:A152	R:R:F71	4.16	No	Yes	0	8	6
40	R:R:F71	R:R:M156	3.73	Yes	No	0	6	9
41	R:R:F72	R:R:L127	18.27	No	No	0	9	8
42	R:R:D131	R:R:F72	7.17	No	No	0	9	9
43	R:R:F72	R:R:K155	3.72	No	No	0	9	7
44	R:R:I128	R:R:L73	4.28	Yes	Yes	2	9	8
45	R:R:H416	R:R:L73	5.14	Yes	Yes	2	9	8
46	R:R:F419	R:R:L73	6.09	Yes	Yes	2	9	8
47	R:R:I78	R:R:L74	7.14	No	No	0	8	8
48	R:R:N124	R:R:N75	16.35	No	No	0	8	9
49	R:R:M156	R:R:N75	11.22	No	No	0	9	9
50	R:R:N75	R:R:W160	12.43	No	Yes	0	9	9
51	R:R:D80	R:R:L76	4.07	Yes	Yes	2	9	9
52	R:R:L76	R:R:N124	8.24	Yes	No	0	9	8
53	R:R:I128	R:R:L76	4.28	Yes	Yes	2	9	9
54	R:R:L76	R:R:N408	10.98	Yes	Yes	2	9	9
55	R:R:L76	R:R:Y412	4.69	Yes	Yes	2	9	9
56	R:R:S120	R:R:S79	6.52	No	No	4	8	8
57	R:R:S79	R:R:W160	3.71	No	Yes	4	8	9
58	R:R:D80	R:R:S121	7.36	Yes	No	0	9	9
59	R:R:D80	R:R:S405	8.83	Yes	No	0	9	9
60	R:R:D80	R:R:N408	8.08	Yes	Yes	2	9	9
61	R:R:F81	R:R:L82	3.65	Yes	No	0	8	6
62	R:R:L117	R:R:L82	6.92	No	No	0	7	6
63	R:R:G84	R:R:V83	3.68	No	Yes	0	9	9
64	R:R:L117	R:R:V83	4.47	No	Yes	0	7	9
65	R:R:V83	R:R:W402	3.68	Yes	Yes	0	9	8
66	R:R:S405	R:R:V83	8.08	No	Yes	0	9	9
67	R:R:G84	R:R:I88	5.29	No	No	0	9	9
68	R:R:F86	R:R:L90	3.65	No	No	0	6	6
69	R:R:F86	R:R:V113	6.55	No	No	0	6	6
70	R:R:C87	R:R:D114	9.34	No	Yes	0	9	9
71	R:R:I88	R:R:W402	18.79	No	Yes	0	9	8
72	R:R:Y91	R:R:Y94	13.9	Yes	No	0	8	6
73	R:R:V95	R:R:Y91	5.05	No	Yes	0	6	8
74	R:R:W110	R:R:Y91	11.58	Yes	Yes	0	6	8
75	R:R:E395	R:R:Y91	6.73	No	Yes	0	6	8
76	R:R:F398	R:R:Y91	12.38	Yes	Yes	1	7	8
77	R:R:W402	R:R:Y91	8.68	Yes	Yes	1	8	8
78	R:R:P93	R:R:V92	3.53	No	No	0	7	7
79	R:R:F102	R:R:P93	5.78	Yes	No	0	8	7
80	R:R:W100	R:R:Y94	7.72	Yes	No	0	9	6
81	R:R:H187	R:R:Y94	4.36	No	No	0	3	6
82	R:R:G186	R:R:R99	6	No	No	0	3	4
83	R:R:F102	R:R:W100	15.03	Yes	Yes	0	8	9
84	R:R:C107	R:R:W100	5.22	No	Yes	5	9	9
85	R:R:W100	R:R:W110	3.75	Yes	Yes	0	9	6
86	R:R:C188	R:R:W100	16.98	No	Yes	5	9	9
87	R:R:F102	R:R:L106	6.09	Yes	No	0	8	5
88	R:R:R104	R:R:S181	3.95	No	No	0	4	4
89	R:R:C107	R:R:C188	7.28	No	No	5	9	9
90	R:R:K108	R:R:L172	8.46	No	No	0	7	5
91	R:R:D114	R:R:W110	7.82	Yes	Yes	0	9	6
92	R:R:I171	R:R:L111	4.28	Yes	No	0	7	7
93	R:R:C188	R:R:L111	4.76	No	No	0	9	7
94	R:R:I171	R:R:V112	4.61	Yes	No	0	7	8
95	R:R:D114	R:R:W402	11.17	Yes	Yes	1	9	8
96	R:R:Y115	R:R:Y167	15.89	Yes	Yes	1	9	8
97	R:R:I171	R:R:Y115	4.84	Yes	Yes	1	7	9
98	R:R:F192	R:R:Y115	4.13	Yes	Yes	1	7	9
99	R:R:L116	R:R:W160	4.56	No	Yes	0	8	9
100	R:R:F123	R:R:T119	5.19	No	No	0	7	9
101	R:R:E206	R:R:T119	14.11	Yes	No	0	8	9
102	R:R:S120	R:R:W160	9.88	No	Yes	4	8	9
103	R:R:A122	R:R:W371	5.19	No	Yes	0	9	8
104	R:R:N124	R:R:V159	5.91	No	No	0	8	8
105	R:R:F367	R:R:I125	3.77	Yes	No	0	9	8
106	R:R:I125	R:R:N408	5.66	No	Yes	0	8	9
107	R:R:I125	R:R:Y412	8.46	No	Yes	0	8	9
108	R:R:P210	R:R:V126	3.53	No	No	0	9	8
109	R:R:I128	R:R:R132	5.01	Yes	No	2	9	9
110	R:R:I128	R:R:Y412	8.46	Yes	Yes	2	9	9
111	R:R:S129	R:R:V214	8.08	No	No	0	9	9
112	R:R:L134	R:R:Y130	12.89	No	No	0	5	7
113	R:R:F217	R:R:Y130	9.28	No	No	0	8	7
114	R:R:D131	R:R:Y142	11.49	No	No	0	9	9
115	R:R:R132	R:R:Y412	8.23	No	Yes	2	9	9
116	R:R:F133	R:R:T137	11.67	No	No	0	9	8
117	R:R:F133	R:R:F217	9.65	No	No	0	9	8
118	R:R:F133	R:R:S220	5.28	No	No	0	9	8
119	R:R:S135	R:R:Y142	8.9	No	No	0	9	9
120	R:R:N224	R:R:T137	4.39	No	No	0	7	8
121	R:R:Q145	R:R:S141	7.22	No	No	0	6	5
122	R:R:Q145	R:R:R151	15.19	No	No	0	6	7
123	R:R:D148	R:R:R151	14.29	No	No	0	8	7
124	R:R:K155	R:R:R154	7.43	No	No	0	7	3
125	R:R:L158	R:R:L162	5.54	No	No	0	4	6
126	R:R:F164	R:R:G168	9.03	No	No	0	7	6
127	R:R:L166	R:R:Y167	7.03	No	Yes	0	8	8
128	R:R:F192	R:R:Y167	5.16	Yes	Yes	1	7	8
129	R:R:A202	R:R:Y167	4	No	Yes	0	9	8
130	R:R:E206	R:R:Y167	15.71	Yes	Yes	0	8	8
131	R:R:G168	R:R:P169	4.06	No	No	0	6	8
132	R:R:A170	R:R:F198	4.16	No	Yes	0	8	7
133	R:R:F192	R:R:I171	3.77	Yes	Yes	1	7	7
134	R:R:S178	R:R:W174	6.18	No	Yes	0	3	5
135	R:R:E191	R:R:W174	9.81	No	Yes	0	8	5
136	R:R:F192	R:R:W174	4.01	Yes	Yes	0	7	5
137	R:R:N195	R:R:W174	4.52	No	Yes	0	6	5
138	R:R:E175	R:R:E191	17.76	No	No	0	5	8
139	R:R:I183	R:R:Y189	9.67	No	Yes	0	4	4
140	R:R:E191	R:R:I183	5.47	No	No	0	8	4
141	R:R:H187	R:R:P184	7.63	No	No	0	3	3
142	R:R:P184	R:R:Y189	4.17	No	Yes	0	3	4
143	R:R:F193	R:R:Y189	14.44	Yes	Yes	1	5	4
144	R:R:Y189	R:R:Y194	3.97	Yes	Yes	1	4	6
145	R:R:A190	R:R:F192	8.32	No	Yes	0	7	7
146	R:R:F192	R:R:F198	19.29	Yes	Yes	0	7	7
147	R:R:F193	R:R:Y194	5.16	Yes	Yes	1	5	6
148	R:R:F193	R:R:M378	6.22	Yes	No	1	5	8
149	R:R:F193	R:R:R381	19.24	Yes	Yes	1	5	4
150	R:R:F193	R:R:Y394	8.25	Yes	Yes	1	5	4
151	R:R:R381	R:R:Y194	7.2	Yes	Yes	1	4	6
152	R:R:F198	R:R:N195	4.83	Yes	No	0	7	6
153	R:R:W196	R:R:Y197	10.61	Yes	No	0	5	5
154	R:R:A202	R:R:F198	4.16	No	Yes	0	9	7
155	R:R:I200	R:R:I379	5.89	No	No	0	7	6
156	R:R:F208	R:R:T204	6.49	Yes	No	0	7	6
157	R:R:E206	R:R:W371	7.63	Yes	Yes	0	8	8
158	R:R:F207	R:R:F208	5.36	Yes	Yes	0	9	7
159	R:R:F207	R:R:F211	7.5	Yes	Yes	1	9	8
160	R:R:F207	R:R:F367	5.36	Yes	Yes	1	9	9
161	R:R:F207	R:R:W371	11.02	Yes	Yes	1	9	8
162	R:R:F207	R:R:T375	9.08	Yes	No	0	9	8
163	R:R:F211	R:R:T215	7.78	Yes	No	0	8	6
164	R:R:F211	R:R:F367	4.29	Yes	Yes	1	8	9
165	R:R:F211	R:R:G368	4.52	Yes	No	0	8	7
166	R:R:N218	R:R:V214	4.43	No	No	0	9	9
167	R:R:F216	R:R:F217	4.29	No	No	0	5	8
168	R:R:F216	R:R:S220	7.93	No	No	0	5	8
169	R:R:L360	R:R:N218	8.24	No	No	0	8	9
170	R:R:N218	R:R:V364	4.43	No	No	0	9	8
171	R:R:Q226	R:R:Y222	18.04	No	No	0	7	7
172	R:R:N224	R:R:R227	6.03	No	Yes	0	7	5
173	R:R:D353	R:R:I225	5.6	No	No	0	9	8
174	R:R:R227	R:R:R228	5.33	Yes	No	0	5	8
175	R:R:R349	R:R:T229	11.64	Yes	No	0	6	6
176	R:R:D353	R:R:T229	8.67	No	No	0	9	6
177	R:R:R232	R:R:R349	10.66	No	Yes	0	5	6
178	R:R:L233	R:R:L350	4.15	No	No	0	5	6
179	R:R:S343	R:R:T345	4.8	No	No	0	3	7
180	R:R:Q346	R:R:S343	5.78	No	No	0	5	3
181	R:R:F348	R:R:S351	3.96	No	No	0	4	6
182	R:R:R349	R:R:R352	4.26	Yes	No	0	6	8
183	R:R:I363	R:R:Y412	4.84	No	Yes	0	8	9
184	R:R:I366	R:R:L411	4.28	No	No	0	7	9
185	R:R:F367	R:R:W371	7.02	Yes	Yes	1	9	8
186	R:R:C370	R:R:N404	9.45	No	No	0	8	9
187	R:R:L401	R:R:W371	13.67	No	Yes	1	8	8
188	R:R:N404	R:R:W371	5.65	No	Yes	0	9	8
189	R:R:M378	R:R:Y374	15.57	No	Yes	1	8	9
190	R:R:Y374	R:R:Y394	7.94	Yes	Yes	1	9	4
191	R:R:S397	R:R:Y374	7.63	No	Yes	0	7	9
192	R:R:F398	R:R:Y374	10.32	Yes	Yes	1	7	9
193	R:R:L401	R:R:Y374	4.69	No	Yes	1	8	9
194	R:R:L377	R:R:S397	6.01	No	No	0	7	7
195	R:R:M378	R:R:R381	6.2	No	Yes	1	8	4
196	R:R:R381	R:R:V389	5.23	Yes	No	0	4	5
197	R:R:C384	R:R:C388	7.28	No	No	0	7	8
198	R:R:P390	R:R:V389	3.53	No	No	0	7	5
199	R:R:P390	R:R:Y392	5.56	No	No	6	7	3
200	R:R:P390	R:R:W393	17.57	No	No	6	7	6
201	R:R:W393	R:R:Y392	8.68	No	No	6	6	3
202	R:R:E395	R:R:Y394	6.73	No	Yes	0	6	4
203	R:R:F398	R:R:Y394	6.19	Yes	Yes	1	7	4
204	R:R:E395	R:R:W399	4.36	No	No	0	6	9
205	R:R:F398	R:R:W402	11.02	Yes	Yes	1	7	8
206	R:R:W399	R:R:W402	7.5	No	Yes	0	9	8
207	R:R:N404	R:R:N408	10.9	No	Yes	0	9	9
208	R:R:L411	R:R:V407	4.47	No	No	0	9	7
209	R:R:H416	R:R:S418	5.58	Yes	No	0	9	8
210	R:R:F419	R:R:H416	6.79	Yes	Yes	2	9	9
211	R:R:H417	R:R:R421	10.16	No	No	0	5	6
212	R:R:L411	R:R:Y412	3.52	No	Yes	0	9	9
213	R:R:P210	R:R:T209	3.5	No	No	0	9	7
214	R:R:L90	R:R:W110	3.42	No	Yes	0	6	6
215	R:R:H417	R:R:R420	3.39	No	No	0	5	9
216	R:R:A163	R:R:T119	3.36	No	No	0	8	9
217	R:R:L400	R:R:P373	3.28	No	No	0	9	9
218	R:R:F419	R:R:F423	3.22	Yes	Yes	0	9	9
219	R:R:F344	R:R:R347	3.21	No	No	0	4	5
220	R:R:S203	R:R:T375	3.2	No	No	0	8	8
221	R:R:R228	R:R:R349	3.2	No	Yes	0	8	6
222	R:R:T215	R:R:V364	3.17	No	No	0	6	8
223	R:R:A77	R:R:N52	3.13	No	No	0	9	9
224	R:R:I221	R:R:V136	3.07	No	No	0	9	8
225	R:R:I225	R:R:V356	3.07	No	No	0	8	8
226	R:R:K355	R:R:S359	3.06	No	No	0	8	9
227	R:R:I200	R:R:T201	3.04	No	No	0	7	6
228	R:R:K358	R:R:V362	3.04	No	No	0	7	8
229	R:R:A152	R:R:Q68	3.03	No	No	0	8	8
230	R:R:G386	R:R:R381	3	No	Yes	0	3	4
231	R:R:L96	R:R:V92	2.98	No	No	0	7	7
232	R:R:L109	R:R:V113	2.98	No	No	0	6	6
233	R:R:L172	R:R:V112	2.98	No	No	0	5	8
234	R:R:L157	R:R:V153	2.98	No	No	0	5	5
235	R:R:L360	R:R:V356	2.98	No	No	0	8	8
236	R:R:N224	R:R:V136	2.96	No	No	0	7	8
237	R:R:L44	R:R:T48	2.95	No	No	0	7	9
238	R:R:F123	R:R:P210	2.89	No	No	0	7	9
239	R:R:E175	R:R:S181	2.87	No	No	0	5	4
240	R:R:G103	R:R:W100	2.81	No	Yes	0	8	9
241	R:R:A58	R:R:F423	2.77	No	Yes	0	9	9
242	R:R:A85	R:R:F81	2.77	No	Yes	0	6	8
243	R:R:L166	R:R:L205	2.77	No	No	0	8	6
244	R:R:A372	R:R:F207	2.77	No	Yes	0	7	9
245	R:R:L219	R:R:L223	2.77	No	No	0	4	5
246	R:R:A357	R:R:Y222	2.67	No	No	0	8	7
247	R:R:L233	R:R:Q346	2.66	No	No	0	5	5
248	R:R:F164	R:R:V112	2.62	No	No	0	7	8
249	R:R:D353	R:R:Q226	2.61	No	No	0	9	7
250	R:R:F102	R:R:T101	2.59	Yes	No	0	8	5
251	R:R:R138	R:R:T137	2.59	No	No	0	6	8
252	R:R:A382	R:R:W196	2.59	No	Yes	0	7	5
253	R:R:A383	R:R:W196	2.59	No	Yes	0	5	5
254	R:R:F208	R:R:I379	2.51	Yes	No	0	7	6
255	R:R:F192	R:R:L199	2.44	Yes	No	0	7	8
256	R:R:F423	R:R:L414	2.44	Yes	No	0	9	7
257	R:R:L158	R:R:R154	2.43	No	No	0	4	3
258	R:R:L233	R:R:R232	2.43	No	No	0	5	5
259	R:R:D234	R:R:R230	2.38	No	No	0	4	6
260	R:R:I379	R:R:W196	2.35	No	Yes	0	6	5
261	R:R:L223	R:R:Y222	2.34	No	No	0	5	7
262	R:R:R227	R:R:R230	2.13	Yes	No	0	5	6
263	R:R:G179	R:R:G180	2.11	No	No	0	5	2
264	R:R:C384	R:R:G386	1.96	No	No	0	7	3
265	R:R:A372	R:R:P373	1.87	No	No	0	7	9
266	R:R:G147	R:R:T67	1.82	No	No	0	6	8
267	R:R:G98	R:R:T97	1.82	No	No	0	7	5
268	R:R:A422	R:R:A58	1.79	No	No	0	9	9
269	R:R:G51	R:R:L50	1.71	No	No	0	9	5
270	R:R:A406	R:R:T48	1.68	No	No	0	7	9
271	R:R:C388	R:R:I380	1.64	No	No	0	8	7
272	R:R:S213	R:R:V126	1.62	No	No	0	8	8
273	R:R:A53	R:R:M56	1.61	No	No	0	6	7
274	R:R:A58	R:R:L426	1.58	No	No	0	9	8
275	R:R:I366	R:R:V362	1.54	No	No	0	7	8
276	R:R:K355	R:R:V356	1.52	No	No	0	8	8
277	R:R:G105	R:R:R104	1.5	No	No	0	5	4
278	R:R:L177	R:R:S173	1.5	No	No	0	4	6
279	R:R:L50	R:R:V46	1.49	No	No	0	5	5
280	R:R:L165	R:R:V161	1.49	No	No	0	5	5
281	R:R:L414	R:R:V410	1.49	No	No	0	7	7
282	R:R:D62	R:R:S63	1.47	No	No	0	8	8
283	R:R:G186	R:R:W100	1.41	No	Yes	0	3	9
284	R:R:L426	R:R:L57	1.38	No	No	0	8	7
285	R:R:R421	R:R:T424	1.29	No	No	0	6	4
286	R:R:F164	R:R:L165	1.22	No	No	0	7	5
287	R:R:F208	R:R:L376	1.22	Yes	No	0	7	7
288	R:R:L231	R:R:R227	1.21	No	Yes	0	5	5
289	R:R:L350	R:R:R354	1.21	No	No	0	6	7
290	R:R:D148	R:R:R150	1.19	No	No	0	8	7
291	R:R:H385	R:R:H387	1.19	No	No	0	4	4
292	R:R:Q146	R:R:R143	1.17	No	No	0	8	7
293	R:R:L177	R:R:Y176	1.17	No	No	0	4	5
294	R:R:E175	R:R:Y176	1.12	No	No	0	5	5
295	R:R:H385	R:R:Y194	1.09	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.99125	8	1	0
2	R:R:F71	5.614	5	3	6
3	R:R:L73	5.25	4	2	8
4	R:R:L76	6.452	5	2	9
5	R:R:D80	7.014	5	2	9
6	R:R:F81	5.6975	4	0	8
7	R:R:V83	4.9775	4	0	9
8	R:R:Y91	9.72	6	1	8
9	R:R:W100	7.56	7	5	9
10	R:R:F102	7.3725	4	0	8
11	R:R:W110	6.6425	4	0	6
12	R:R:D114	8.8075	4	1	9
13	R:R:Y115	9.195	4	1	9
14	R:R:I128	5.5075	4	2	9
15	R:R:W160	7.645	4	4	9
16	R:R:Y167	9.558	5	1	8
17	R:R:I171	4.375	4	1	7
18	R:R:W174	6.13	4	0	5
19	R:R:Y189	8.0625	4	1	4
20	R:R:F192	6.73143	7	1	7
21	R:R:F193	10.662	5	1	5
22	R:R:Y194	4.355	4	1	6
23	R:R:W196	4.535	4	0	5
24	R:R:F198	8.11	4	0	7
25	R:R:E206	11.0475	4	0	8
26	R:R:F207	6.84833	6	1	9
27	R:R:F208	3.895	4	0	7
28	R:R:F211	6.0225	4	1	8
29	R:R:R227	3.675	4	0	5
30	R:R:R349	7.44	4	0	6
31	R:R:F367	5.11	4	1	9
32	R:R:W371	8.36333	6	1	8
33	R:R:Y374	9.9	6	1	9
34	R:R:R381	8.174	5	1	4
35	R:R:Y394	7.2775	4	1	4
36	R:R:F398	11.422	5	1	7
37	R:R:W402	9.88714	7	1	8
38	R:R:N408	8.905	4	2	9
39	R:R:Y412	6.36667	6	2	9
40	R:R:H416	5.9725	4	2	9
41	R:R:F419	5.644	5	2	9
42	R:R:F423	6.37	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W402	37.2311	8.37	Yes	Yes	1	0	8
2	R:R:I88	R:R:W402	11.078	18.79	No	Yes	0	9	8
3	R:R:V83	R:R:W402	40.7254	3.68	Yes	Yes	0	9	8
4	R:R:G84	R:R:T48	10.3221	3.64	No	No	0	9	9
5	R:R:L117	R:R:V83	13.7078	4.47	No	Yes	0	7	9
6	R:R:L117	R:R:L82	11.7455	6.92	No	No	0	7	6
7	R:R:S405	R:R:V83	30.1178	8.08	No	Yes	0	9	9
8	R:R:D80	R:R:S405	30.0937	8.83	Yes	No	0	9	9
9	L:L:?1	R:R:E206	39.7362	6.74	Yes	Yes	0	0	8
10	R:R:E206	R:R:W371	81.5192	7.63	Yes	Yes	0	8	8
11	R:R:F367	R:R:W371	62.403	7.02	Yes	Yes	1	9	8
12	R:R:F367	R:R:I125	46.3308	3.77	Yes	No	0	9	8
13	R:R:I125	R:R:Y412	35.7312	8.46	No	Yes	0	8	9
14	R:R:I128	R:R:Y412	24.1465	8.46	Yes	Yes	2	9	9
15	R:R:I128	R:R:L73	53.8703	4.28	Yes	Yes	2	9	8
16	R:R:F419	R:R:L73	32.8521	6.09	Yes	Yes	2	9	8
17	R:R:F419	R:R:F423	16.4261	3.22	Yes	Yes	0	9	9
18	L:L:?1	R:R:L401	35.1924	10.17	Yes	No	1	0	8
19	R:R:L401	R:R:W371	63.9189	13.67	No	Yes	1	8	8
20	R:R:N404	R:R:W371	30.9059	5.65	No	Yes	0	9	8
21	R:R:N404	R:R:N408	29.2251	10.9	No	Yes	0	9	9
22	R:R:L76	R:R:N408	32.2369	10.98	Yes	Yes	2	9	9
23	R:R:I128	R:R:L76	31.5694	4.28	Yes	Yes	2	9	9
24	R:R:D80	R:R:L76	24.7698	4.07	Yes	Yes	2	9	9
25	R:R:L76	R:R:N124	33.5759	8.24	Yes	No	0	9	8
26	R:R:N124	R:R:N75	30.5119	16.35	No	No	0	8	9
27	R:R:M156	R:R:N75	22.711	11.22	No	No	0	9	9
28	R:R:F71	R:R:M156	21.1267	3.73	Yes	No	0	6	9
29	R:R:A152	R:R:F71	11.452	4.16	No	Yes	0	8	6
30	R:R:L73	R:R:N69	17.7289	5.49	Yes	No	2	8	8
31	R:R:D131	R:R:N69	16.7518	12.12	No	No	0	9	8
32	R:R:D131	R:R:F72	11.2389	7.17	No	No	0	9	9
33	L:L:?1	R:R:D114	19.2167	6.9	Yes	Yes	1	0	9
34	R:R:D114	R:R:W110	22.1561	7.82	Yes	Yes	0	9	6
35	R:R:W402	R:R:Y91	15.1956	8.68	Yes	Yes	1	8	8
36	R:R:Y91	R:R:Y94	11.5324	13.9	Yes	No	0	8	6
37	R:R:W100	R:R:W110	19.6027	3.75	Yes	Yes	0	9	6
38	R:R:F102	R:R:W100	10.2135	15.03	Yes	Yes	0	8	9
39	L:L:?1	R:R:Y115	30.8135	11.92	Yes	Yes	1	0	9
40	R:R:I171	R:R:Y115	32.635	4.84	Yes	Yes	1	7	9
41	R:R:F192	R:R:W174	14.882	4.01	Yes	Yes	0	7	5
42	R:R:E191	R:R:W174	11.838	9.81	No	Yes	0	8	5
43	R:R:E175	R:R:E191	10.2457	17.76	No	No	0	5	8
44	R:R:I171	R:R:V112	33.5438	4.61	Yes	No	0	7	8
45	R:R:Y115	R:R:Y167	11.5726	15.89	Yes	Yes	1	9	8
46	R:R:E206	R:R:Y167	42.6032	15.71	Yes	Yes	0	8	8
47	R:R:E206	R:R:T119	10.6076	14.11	Yes	No	0	8	9
48	R:R:F207	R:R:W371	57.642	11.02	Yes	Yes	1	9	8
49	R:R:F207	R:R:F211	43.8659	7.5	Yes	Yes	1	9	8
50	R:R:F211	R:R:T215	100	7.78	Yes	No	0	8	6
51	R:R:T215	R:R:V364	97.8125	3.17	No	No	0	6	8
52	R:R:N218	R:R:V364	95.617	4.43	No	No	0	9	8
53	R:R:F211	R:R:F367	60.4809	4.29	Yes	Yes	1	8	9
54	R:R:L360	R:R:N218	88.9823	8.24	No	No	0	8	9
55	R:R:L360	R:R:V356	86.7425	2.98	No	No	0	8	8
56	R:R:I225	R:R:V356	80.337	3.07	No	No	0	8	8
57	R:R:D353	R:R:I225	78.4028	5.6	No	No	0	9	8
58	R:R:D353	R:R:T229	64.6749	8.67	No	No	0	9	6
59	R:R:R349	R:R:T229	62.3588	11.64	Yes	No	0	6	6
60	R:R:R228	R:R:R349	41.1476	3.2	No	Yes	0	8	6
61	R:R:R227	R:R:R228	38.7591	5.33	Yes	No	0	5	8
62	R:R:N224	R:R:R227	29.0924	6.03	No	Yes	0	7	5
63	R:R:N224	R:R:T137	22.0918	4.39	No	No	0	7	8
64	R:R:F133	R:R:T137	17.5037	11.67	No	No	0	9	8
65	R:R:F133	R:R:F217	10.0285	9.65	No	No	0	9	8
66	R:R:F164	R:R:V112	21.2272	2.62	No	No	0	7	8
67	R:R:M378	R:R:Y374	23.5192	15.57	No	Yes	1	8	9
68	R:R:F193	R:R:Y394	13.1047	8.25	Yes	Yes	1	5	4
69	R:R:M378	R:R:R381	15.7988	6.2	No	Yes	1	8	4
70	R:R:F207	R:R:F208	16.2371	5.36	Yes	Yes	0	9	7
71	R:R:F208	R:R:I379	11.3997	2.51	Yes	No	0	7	6
72	R:R:D353	R:R:Q226	12.5297	2.61	No	No	0	9	7
73	R:R:Q226	R:R:Y222	10.0446	18.04	No	No	0	7	7
74	R:R:R232	R:R:R349	17.4876	10.66	No	Yes	0	5	6
75	R:R:L233	R:R:R232	15.0187	2.43	No	No	0	5	5
76	R:R:F192	R:R:Y167	25.5941	5.16	Yes	Yes	1	7	8
77	R:R:F192	R:R:I171	11.0258	3.77	Yes	Yes	1	7	7
78	R:R:L401	R:R:Y374	28.3566	4.69	No	Yes	1	8	9
79	R:R:I125	R:R:N408	10.2537	5.66	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D114	6.9	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y115	11.92	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:C118	5.38	1	Yes	No	0	8	0	1
L:L:?1	R:R:E206	6.74	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y374	13.25	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F398	17.2	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L401	10.17	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	8.37	1	Yes	Yes	0	8	0	1
R:R:V83	R:R:W402	3.68	0	Yes	Yes	9	8	2	1
R:R:C87	R:R:D114	9.34	0	No	Yes	9	9	2	1
R:R:I88	R:R:W402	18.79	0	No	Yes	9	8	2	1
R:R:W110	R:R:Y91	11.58	0	Yes	Yes	6	8	2	2
R:R:F398	R:R:Y91	12.38	1	Yes	Yes	7	8	1	2
R:R:W402	R:R:Y91	8.68	1	Yes	Yes	8	8	1	2
R:R:D114	R:R:W110	7.82	1	Yes	Yes	9	6	1	2
R:R:D114	R:R:W402	11.17	1	Yes	Yes	9	8	1	1
R:R:Y115	R:R:Y167	15.89	1	Yes	Yes	9	8	1	2
R:R:I171	R:R:Y115	4.84	1	Yes	Yes	7	9	2	1
R:R:F192	R:R:Y115	4.13	1	Yes	Yes	7	9	2	1
R:R:E206	R:R:T119	14.11	0	Yes	No	8	9	1	2
R:R:F192	R:R:Y167	5.16	1	Yes	Yes	7	8	2	2
R:R:E206	R:R:Y167	15.71	0	Yes	Yes	8	8	1	2
R:R:F192	R:R:I171	3.77	1	Yes	Yes	7	7	2	2
R:R:E206	R:R:W371	7.63	0	Yes	Yes	8	8	1	2
R:R:L401	R:R:W371	13.67	1	No	Yes	8	8	1	2
R:R:M378	R:R:Y374	15.57	1	No	Yes	8	9	2	1
R:R:Y374	R:R:Y394	7.94	1	Yes	Yes	9	4	1	2
R:R:S397	R:R:Y374	7.63	0	No	Yes	7	9	2	1
R:R:F398	R:R:Y374	10.32	1	Yes	Yes	7	9	1	1
R:R:L401	R:R:Y374	4.69	1	No	Yes	8	9	1	1
R:R:F398	R:R:Y394	6.19	1	Yes	Yes	7	4	1	2
R:R:F398	R:R:W402	11.02	1	Yes	Yes	7	8	1	1
R:R:W399	R:R:W402	7.5	0	No	Yes	9	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YN7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	262
Number of Links	295
Number of Hubs	42
Number of Links mediated by Hubs	149
Number of Communities	6
Number of Nodes involved in Communities	45
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	65454
Length Of Smallest Path	3
Average Path Length	13.8115
Length of Longest Path	31
Minimum Path Strength	1.14
Average Path Strength	7.06435
Maximum Path Strength	17.075
Minimum Path Correlation	0.7
Average Path Correlation	0.926883
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	47.9591
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.373
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cellular localization • neurotransmitter secretion • transport • secretion • export from cell • neurotransmitter transport • establishment of localization • localization • signal release from synapse • secretion by cell • signal release • establishment of localization in cell • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5N1
Sequence	>8YN7_nogp_Chain_R T A V L A A L M A L L I V A T V L G N A L V M L A F V A D S S L R T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R W T F G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R A V S Y R A Q Q G D T R R A V R K M L L V W V L A F L L Y G P A I L S W E Y L S G G S S I P E G H C Y A E F F Y N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D S F T Q R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C H G H C V P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F R R A F T K L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR0	Na	-	1.71	2025-06-18	To be published
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8TH3	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	AT118-H Nanobody	-	3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	9JH3	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	8YUV	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-	Gi1/β1/γ2	3	2024-06-05	doi.org/10.1002/advs.202310120
	8YUV (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-		3	2024-06-05	doi.org/10.1002/advs.202310120
	7F61	A	Amine	Histamine	H₃	Homo sapiens	PF-03654746	-	-	2.6	2022-10-26	doi.org/10.1038/s41467-022-33880-y
	8YN7	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN7 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YUU	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ1	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUU (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YN5	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-	Gi1/β1/γ2	2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-		2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb

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