psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V36	R:R:W33	4.9	No	No	0	4	3
2	R:R:M41	R:R:V92	6.09	Yes	No	0	7	7
3	R:R:M41	R:R:V95	6.09	Yes	No	0	7	6
4	R:R:L96	R:R:M41	4.24	No	Yes	0	7	7
5	R:R:M41	R:R:W399	4.65	Yes	Yes	0	7	9
6	R:R:I45	R:R:I88	7.36	No	No	0	7	9
7	R:R:I45	R:R:P89	5.08	No	No	0	7	9
8	R:R:A77	R:R:N52	4.69	No	No	0	9	9
9	R:R:F81	R:R:N52	6.04	Yes	No	0	8	9
10	R:R:N52	R:R:P409	9.77	No	No	0	9	9
11	R:R:F423	R:R:L54	14.61	Yes	No	0	9	8
12	R:R:P413	R:R:V55	8.84	No	No	0	9	9
13	R:R:L74	R:R:M56	4.24	No	No	0	8	7
14	R:R:F81	R:R:M56	6.22	Yes	No	0	8	7
15	R:R:L426	R:R:L57	9.69	No	No	0	8	7
16	R:R:A58	R:R:F423	4.16	No	Yes	0	9	9
17	R:R:F59	R:R:R66	16.03	No	No	0	8	8
18	R:R:F59	R:R:F71	6.43	No	Yes	0	8	6
19	R:R:F59	R:R:L74	4.87	No	No	0	8	8
20	R:R:D62	R:R:S64	7.36	Yes	No	0	8	7
21	R:R:D62	R:R:L65	8.14	Yes	No	0	8	9
22	R:R:A422	R:R:D62	4.63	No	Yes	0	9	8
23	R:R:L65	R:R:N70	8.24	No	Yes	2	9	9
24	R:R:L65	R:R:S418	6.01	No	Yes	2	9	8
25	R:R:N70	R:R:T67	10.24	Yes	No	0	9	8
26	R:R:F72	R:R:Q68	7.03	Yes	No	0	9	8
27	R:R:Q68	R:R:R151	4.67	No	No	0	8	7
28	R:R:A152	R:R:Q68	4.55	No	No	0	8	8
29	R:R:D131	R:R:N69	6.73	No	No	0	9	8
30	R:R:H416	R:R:N70	7.65	No	Yes	2	9	9
31	R:R:N70	R:R:S418	4.47	Yes	Yes	2	9	8
32	R:R:F419	R:R:N70	8.46	Yes	Yes	2	9	9
33	R:R:F71	R:R:T149	6.49	Yes	No	0	6	6
34	R:R:A152	R:R:F71	4.16	No	Yes	0	8	6
35	R:R:F71	R:R:M156	6.22	Yes	No	0	6	9
36	R:R:F72	R:R:L127	18.27	Yes	No	3	9	8
37	R:R:D131	R:R:F72	8.36	No	Yes	0	9	9
38	R:R:F72	R:R:K155	4.96	Yes	No	3	9	7
39	R:R:I128	R:R:L73	4.28	No	No	0	9	8
40	R:R:F419	R:R:L73	6.09	Yes	No	0	9	8
41	R:R:I78	R:R:L74	7.14	No	No	0	8	8
42	R:R:N124	R:R:N75	12.26	No	No	0	8	9
43	R:R:M156	R:R:N75	9.82	No	No	0	9	9
44	R:R:N75	R:R:W160	11.3	No	No	0	9	9
45	R:R:L76	R:R:N408	6.87	No	No	0	9	9
46	R:R:L76	R:R:Y412	4.69	No	Yes	0	9	9
47	R:R:L117	R:R:S79	6.01	No	No	0	7	8
48	R:R:S120	R:R:S79	4.89	Yes	No	0	8	8
49	R:R:D80	R:R:S121	7.36	No	No	0	9	9
50	R:R:D80	R:R:S405	10.31	No	No	0	9	9
51	R:R:D80	R:R:N408	8.08	No	No	0	9	9
52	R:R:A85	R:R:F81	4.16	No	Yes	0	6	8
53	R:R:L117	R:R:L82	6.92	No	No	0	7	6
54	R:R:L117	R:R:V83	4.47	No	No	0	7	9
55	R:R:V83	R:R:W402	6.13	No	Yes	0	9	8
56	R:R:S405	R:R:V83	4.85	No	No	0	9	9
57	R:R:F86	R:R:L90	9.74	No	No	0	6	6
58	R:R:F86	R:R:V113	7.87	No	No	0	6	6
59	R:R:C87	R:R:D114	6.22	No	Yes	0	9	9
60	R:R:I88	R:R:W402	9.4	No	Yes	0	9	8
61	R:R:L90	R:R:W110	4.56	No	Yes	0	6	6
62	R:R:Y91	R:R:Y94	8.94	Yes	No	0	8	6
63	R:R:V95	R:R:Y91	5.05	No	Yes	0	6	8
64	R:R:W110	R:R:Y91	10.61	Yes	Yes	0	6	8
65	R:R:E395	R:R:Y91	5.61	No	Yes	1	6	8
66	R:R:F398	R:R:Y91	10.32	Yes	Yes	1	7	8
67	R:R:W399	R:R:Y91	5.79	Yes	Yes	1	9	8
68	R:R:W402	R:R:Y91	7.72	Yes	Yes	1	8	8
69	R:R:F102	R:R:P93	4.33	Yes	No	0	8	7
70	R:R:H187	R:R:Y94	9.8	No	No	0	3	6
71	R:R:E185	R:R:R99	18.61	No	No	0	1	4
72	R:R:H187	R:R:R99	12.41	No	No	0	3	4
73	R:R:F102	R:R:W100	17.04	Yes	Yes	0	8	9
74	R:R:C107	R:R:W100	5.22	No	Yes	4	9	9
75	R:R:W100	R:R:W110	8.43	Yes	Yes	0	9	6
76	R:R:C188	R:R:W100	13.06	No	Yes	4	9	9
77	R:R:F102	R:R:T101	7.78	Yes	No	0	8	5
78	R:R:F102	R:R:L106	6.09	Yes	No	0	8	5
79	R:R:C107	R:R:C188	7.28	No	No	4	9	9
80	R:R:K108	R:R:L172	4.23	No	No	0	7	5
81	R:R:K108	R:R:Y176	4.78	No	No	0	7	5
82	R:R:L111	R:R:W110	4.56	No	Yes	0	7	6
83	R:R:D114	R:R:W110	7.82	Yes	Yes	0	9	6
84	R:R:C188	R:R:L111	4.76	No	No	0	9	7
85	R:R:I171	R:R:V112	4.61	No	No	0	7	8
86	R:R:L172	R:R:V112	4.47	No	No	0	5	8
87	R:R:D114	R:R:W402	10.05	Yes	Yes	1	9	8
88	L:L:?1	R:R:D114	6.9	Yes	Yes	1	0	9
89	R:R:Y115	R:R:Y167	6.95	No	Yes	0	9	8
90	R:R:F193	R:R:Y115	9.28	Yes	No	0	5	9
91	L:L:?1	R:R:Y115	13.25	Yes	No	0	0	9
92	L:L:?1	R:R:C118	5.38	Yes	No	0	0	8
93	R:R:F123	R:R:T119	6.49	No	No	0	7	9
94	R:R:E206	R:R:T119	14.11	Yes	No	0	8	9
95	R:R:N124	R:R:S120	4.47	No	Yes	0	8	8
96	R:R:S120	R:R:W160	11.12	Yes	No	0	8	9
97	R:R:A122	R:R:W371	5.19	No	Yes	0	9	8
98	R:R:N124	R:R:V159	7.39	No	No	0	8	8
99	R:R:I125	R:R:Y412	8.46	No	Yes	0	8	9
100	R:R:K155	R:R:L127	4.23	No	No	3	7	8
101	R:R:I128	R:R:R132	5.01	No	No	0	9	9
102	R:R:I128	R:R:Y412	4.84	No	Yes	0	9	9
103	R:R:S129	R:R:V214	8.08	No	No	0	9	9
104	R:R:L134	R:R:Y130	14.07	No	No	0	5	7
105	R:R:F217	R:R:Y130	6.19	Yes	No	0	8	7
106	R:R:D131	R:R:Y142	9.2	No	No	0	9	9
107	R:R:F133	R:R:T137	11.67	No	No	0	9	8
108	R:R:F133	R:R:F217	12.86	No	Yes	0	9	8
109	R:R:F133	R:R:S220	5.28	No	No	0	9	8
110	R:R:S135	R:R:Y142	7.63	No	No	0	9	9
111	R:R:Q146	R:R:Y142	4.51	No	No	0	8	9
112	R:R:Q145	R:R:R151	17.52	No	No	0	6	7
113	R:R:D148	R:R:R151	20.25	No	No	0	8	7
114	R:R:R150	R:R:R154	4.26	No	No	0	7	3
115	R:R:L158	R:R:L162	8.3	No	No	0	4	6
116	R:R:F164	R:R:G168	4.52	Yes	No	0	7	6
117	R:R:F164	R:R:P169	7.22	Yes	No	0	7	8
118	R:R:L166	R:R:Y167	9.38	No	Yes	0	8	8
119	R:R:L166	R:R:L205	4.15	No	No	0	8	6
120	R:R:E206	R:R:Y167	11.22	Yes	Yes	0	8	8
121	R:R:A170	R:R:F192	4.16	No	Yes	0	8	7
122	R:R:E191	R:R:W174	9.81	No	Yes	1	8	5
123	R:R:F192	R:R:W174	9.02	Yes	Yes	1	7	5
124	R:R:F198	R:R:W174	7.02	No	Yes	1	7	5
125	R:R:E175	R:R:E191	5.07	No	No	1	5	8
126	R:R:I183	R:R:Y189	7.25	No	No	0	4	4
127	R:R:H187	R:R:P184	10.68	No	No	0	3	3
128	R:R:P184	R:R:Y189	4.17	No	No	0	3	4
129	R:R:Y189	R:R:Y194	11.91	No	No	0	4	6
130	R:R:A190	R:R:F192	8.32	No	Yes	0	7	7
131	R:R:F192	R:R:F193	16.08	Yes	Yes	1	7	5
132	R:R:F192	R:R:F198	17.15	Yes	No	1	7	7
133	R:R:F193	R:R:L199	6.09	Yes	No	1	5	8
134	R:R:F193	R:R:M378	11.2	Yes	Yes	1	5	8
135	R:R:N195	R:R:Y197	8.14	No	No	0	6	5
136	R:R:W196	R:R:Y197	19.29	No	No	0	5	5
137	R:R:L199	R:R:M378	4.24	No	Yes	1	8	8
138	R:R:I200	R:R:I379	5.89	No	No	0	7	6
139	R:R:I379	R:R:S203	4.64	No	No	0	6	8
140	R:R:E206	R:R:W371	7.63	Yes	Yes	0	8	8
141	L:L:?1	R:R:E206	8.24	Yes	Yes	0	0	8
142	R:R:F207	R:R:F208	9.65	Yes	No	0	9	7
143	R:R:F207	R:R:F211	7.5	Yes	Yes	1	9	8
144	R:R:F207	R:R:F367	5.36	Yes	No	1	9	9
145	R:R:F207	R:R:W371	9.02	Yes	Yes	1	9	8
146	R:R:F207	R:R:T375	6.49	Yes	No	0	9	8
147	R:R:P210	R:R:T209	5.25	No	No	0	9	7
148	R:R:F211	R:R:T215	7.78	Yes	No	0	8	6
149	R:R:F211	R:R:F367	4.29	Yes	No	1	8	9
150	R:R:F211	R:R:G368	4.52	Yes	No	0	8	7
151	R:R:T215	R:R:V364	4.76	No	No	0	6	8
152	R:R:F216	R:R:F217	5.36	No	Yes	0	5	8
153	R:R:F216	R:R:S220	7.93	No	No	0	5	8
154	R:R:L360	R:R:N218	5.49	Yes	No	0	8	9
155	R:R:N218	R:R:V364	4.43	No	No	0	9	8
156	R:R:L219	R:R:L223	5.54	No	No	0	4	5
157	R:R:Q226	R:R:Y222	18.04	No	Yes	0	7	7
158	R:R:N224	R:R:R227	6.03	No	No	0	7	5
159	R:R:D353	R:R:I225	5.6	No	No	0	9	8
160	R:R:L233	R:R:T229	4.42	No	No	0	5	6
161	R:R:R349	R:R:T229	15.52	No	No	0	6	6
162	R:R:D353	R:R:T229	8.67	No	No	0	9	6
163	R:R:D234	R:R:R230	5.96	No	No	0	4	6
164	R:R:R232	R:R:R349	6.4	No	No	0	5	6
165	R:R:L233	R:R:Q346	5.32	No	No	0	5	5
166	R:R:L233	R:R:L350	4.15	No	No	0	5	6
167	R:R:Q346	R:R:S343	10.11	No	No	0	5	3
168	R:R:F344	R:R:F348	5.36	No	No	0	4	4
169	R:R:F348	R:R:R352	5.34	No	No	0	4	8
170	R:R:I363	R:R:L411	5.71	No	No	0	8	9
171	R:R:I363	R:R:Y412	9.67	No	Yes	0	8	9
172	R:R:I366	R:R:L411	4.28	No	No	0	7	9
173	R:R:F367	R:R:W371	13.03	No	Yes	1	9	8
174	R:R:C370	R:R:L400	6.35	No	No	0	8	9
175	R:R:C370	R:R:N404	7.87	No	Yes	0	8	9
176	R:R:L401	R:R:W371	7.97	No	Yes	1	8	8
177	R:R:N404	R:R:W371	6.78	Yes	Yes	0	9	8
178	R:R:M378	R:R:Y374	9.58	Yes	Yes	1	8	9
179	R:R:Y374	R:R:Y394	10.92	Yes	No	0	9	4
180	R:R:F398	R:R:Y374	5.16	Yes	Yes	1	7	9
181	R:R:L401	R:R:Y374	9.38	No	Yes	1	8	9
182	L:L:?1	R:R:Y374	7.95	Yes	Yes	1	0	9
183	R:R:L377	R:R:V389	4.47	No	Yes	0	7	5
184	R:R:L377	R:R:S397	4.5	No	No	0	7	7
185	R:R:M378	R:R:R381	6.2	Yes	No	0	8	4
186	R:R:R381	R:R:V389	5.23	No	Yes	0	4	5
187	R:R:R381	R:R:Y394	16.46	No	No	0	4	4
188	R:R:C384	R:R:C388	7.28	No	No	5	7	8
189	R:R:P390	R:R:Y392	9.74	No	No	6	7	3
190	R:R:P390	R:R:W393	22.97	No	No	6	7	6
191	R:R:W393	R:R:Y392	10.61	No	No	6	6	3
192	R:R:E395	R:R:W399	7.63	No	Yes	1	6	9
193	R:R:F398	R:R:W402	14.03	Yes	Yes	1	7	8
194	L:L:?1	R:R:F398	14.45	Yes	Yes	1	0	7
195	R:R:W399	R:R:W402	11.25	Yes	Yes	1	9	8
196	L:L:?1	R:R:L401	9.38	Yes	No	1	0	8
197	L:L:?1	R:R:W402	5.15	Yes	Yes	1	0	8
198	R:R:N404	R:R:N408	10.9	Yes	No	0	9	9
199	R:R:L414	R:R:V410	4.47	No	No	0	7	7
200	R:R:P413	R:R:Y412	4.17	No	Yes	0	9	9
201	R:R:H416	R:R:S418	9.76	No	Yes	2	9	8
202	R:R:F419	R:R:H416	7.92	Yes	No	2	9	9
203	R:R:K425	R:R:R421	4.95	No	No	0	6	6
204	R:R:G51	R:R:P409	4.06	No	No	0	9	9
205	R:R:E175	R:R:K108	4.05	No	No	0	5	7
206	R:R:A202	R:R:Y167	4	No	Yes	0	9	8
207	R:R:F81	R:R:V49	3.93	Yes	No	0	8	7
208	R:R:I183	R:R:R104	3.76	No	No	0	4	4
209	R:R:F86	R:R:L109	3.65	No	No	0	6	6
210	R:R:F423	R:R:L414	3.65	Yes	No	0	9	7
211	R:R:G84	R:R:T48	3.64	No	No	0	9	9
212	R:R:L231	R:R:R230	3.64	No	No	0	5	6
213	R:R:F198	R:R:N195	3.62	No	No	0	7	6
214	R:R:P373	R:R:S397	3.56	No	No	0	9	7
215	R:R:P390	R:R:V389	3.53	No	Yes	0	7	5
216	R:R:L223	R:R:Y222	3.52	No	Yes	0	5	7
217	R:R:L116	R:R:W160	3.42	No	No	0	8	9
218	R:R:A406	R:R:T48	3.36	No	No	0	7	9
219	R:R:E175	R:R:G180	3.27	No	Yes	1	5	2
220	R:R:E191	R:R:G180	3.27	No	Yes	1	8	2
221	R:R:S135	R:R:V136	3.23	No	No	0	9	8
222	R:R:F419	R:R:F423	3.22	Yes	Yes	0	9	9
223	R:R:V126	R:R:V214	3.21	No	No	0	8	9
224	R:R:S203	R:R:T375	3.2	No	No	0	8	8
225	R:R:S343	R:R:T345	3.2	No	No	0	3	7
226	R:R:I366	R:R:V362	3.07	No	No	0	7	8
227	R:R:I380	R:R:V389	3.07	No	Yes	0	7	5
228	R:R:M156	R:R:V153	3.04	No	No	0	9	5
229	R:R:L40	R:R:V36	2.98	No	No	0	5	4
230	R:R:L50	R:R:V46	2.98	No	No	0	5	5
231	R:R:N218	R:R:S129	2.98	No	No	0	9	9
232	R:R:L157	R:R:V153	2.98	No	No	0	5	5
233	R:R:L165	R:R:V161	2.98	No	No	0	5	5
234	R:R:L360	R:R:V356	2.98	Yes	No	0	8	8
235	R:R:N224	R:R:V136	2.96	No	No	0	7	8
236	R:R:N404	R:R:V407	2.96	Yes	No	0	9	7
237	R:R:L44	R:R:T48	2.95	No	No	0	7	9
238	R:R:I221	R:R:I225	2.94	No	No	0	9	8
239	R:R:I88	R:R:L44	2.85	No	No	0	9	7
240	R:R:I221	R:R:L360	2.85	No	Yes	0	9	8
241	R:R:H417	R:R:S418	2.79	No	Yes	0	5	8
242	R:R:A372	R:R:F207	2.77	No	Yes	0	7	9
243	R:R:A357	R:R:Y222	2.67	No	Yes	0	8	7
244	R:R:F217	R:R:S129	2.64	Yes	No	0	8	9
245	R:R:R138	R:R:S141	2.64	No	No	0	6	5
246	R:R:F164	R:R:V112	2.62	Yes	No	0	7	8
247	R:R:R143	R:R:V140	2.62	No	No	0	7	7
248	R:R:R138	R:R:T137	2.59	No	No	0	6	8
249	R:R:F344	R:R:T345	2.59	No	No	0	4	7
250	R:R:S178	R:R:W174	2.47	No	Yes	0	3	5
251	R:R:F164	R:R:L165	2.44	Yes	No	0	7	5
252	R:R:L231	R:R:R227	2.43	No	No	0	5	5
253	R:R:D62	R:R:R421	2.38	Yes	No	0	8	6
254	R:R:F344	R:R:R347	2.14	No	No	0	4	5
255	R:R:R228	R:R:R349	2.13	No	No	0	8	6
256	R:R:G179	R:R:G180	2.11	No	Yes	0	5	2
257	R:R:G180	R:R:S181	1.86	Yes	No	0	2	4
258	R:R:G98	R:R:T97	1.82	No	No	0	7	5
259	R:R:P210	R:R:V126	1.77	No	No	0	9	8
260	R:R:G186	R:R:I183	1.76	No	No	0	3	4
261	R:R:G51	R:R:L50	1.71	No	No	0	9	5
262	R:R:A163	R:R:S120	1.71	No	Yes	0	8	8
263	R:R:C388	R:R:V389	1.71	No	Yes	0	8	5
264	R:R:D234	R:R:G235	1.68	No	No	0	4	4
265	R:R:A61	R:R:L426	1.58	No	No	0	7	8
266	R:R:A382	R:R:L199	1.58	No	No	0	7	8
267	R:R:A372	R:R:L376	1.58	No	No	0	7	7
268	R:R:T204	R:R:T209	1.57	No	No	0	6	7
269	R:R:K355	R:R:S351	1.53	No	No	0	8	6
270	R:R:G105	R:R:R104	1.5	No	No	0	5	4
271	R:R:L37	R:R:V95	1.49	No	No	0	5	6
272	R:R:L57	R:R:V60	1.49	No	No	0	7	5
273	R:R:L96	R:R:T34	1.47	No	No	0	7	5
274	R:R:C384	R:R:H387	1.47	No	No	5	7	4
275	R:R:C388	R:R:H387	1.47	No	No	5	8	4
276	R:R:A53	R:R:F81	1.39	No	Yes	0	6	8
277	R:R:C415	R:R:R420	1.39	No	No	0	8	9
278	R:R:L40	R:R:L43	1.38	No	No	0	5	4
279	R:R:L426	R:R:L54	1.38	No	No	0	8	8
280	R:R:F217	R:R:S213	1.32	Yes	No	0	8	8
281	R:R:R354	R:R:S351	1.32	No	No	0	7	6
282	R:R:A383	R:R:W196	1.3	No	No	0	5	5
283	R:R:R99	R:R:T97	1.29	No	No	0	4	5
284	R:R:F211	R:R:L212	1.22	Yes	No	0	8	5
285	R:R:L350	R:R:R354	1.21	No	No	0	6	7
286	R:R:D148	R:R:R150	1.19	No	No	0	8	7
287	R:R:L360	R:R:Y222	1.17	Yes	Yes	0	8	7
288	R:R:L37	R:R:W33	1.14	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M41	5.2675	4	0	7
2	R:R:D62	5.6275	4	0	8
3	R:R:N70	7.812	5	2	9
4	R:R:F71	5.825	4	0	6
5	R:R:F72	9.655	4	3	9
6	R:R:F81	4.348	5	0	8
7	R:R:Y91	7.72	7	1	8
8	R:R:W100	10.9375	4	4	9
9	R:R:F102	8.81	4	0	8
10	R:R:W110	7.196	5	0	6
11	R:R:D114	7.7475	4	1	9
12	R:R:S120	5.5475	4	0	8
13	R:R:F164	4.2	4	0	7
14	R:R:Y167	7.8875	4	0	8
15	R:R:W174	7.08	4	1	5
16	R:R:G180	2.6275	4	1	2
17	R:R:F192	10.946	5	1	7
18	R:R:F193	10.6625	4	1	5
19	R:R:E206	10.3	4	0	8
20	R:R:F207	6.79833	6	1	9
21	R:R:F211	5.062	5	1	8
22	R:R:F217	5.674	5	0	8
23	R:R:Y222	6.35	4	0	7
24	R:R:L360	3.1225	4	0	8
25	R:R:W371	8.27	6	1	8
26	R:R:Y374	8.598	5	1	9
27	R:R:M378	7.805	4	1	8
28	R:R:V389	3.602	5	0	5
29	R:R:F398	10.99	4	1	7
30	R:R:W399	7.33	4	1	9
31	R:R:W402	9.10429	7	1	8
32	R:R:N404	7.1275	4	0	9
33	R:R:Y412	6.366	5	0	9
34	R:R:S418	5.7575	4	2	8
35	R:R:F419	6.4225	4	2	9
36	R:R:F423	6.41	4	0	9
37	L:L:?1	8.8375	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V95	R:R:Y91	10.6654	5.05	No	Yes	0	6	8
2	R:R:W402	R:R:Y91	20.6413	7.72	Yes	Yes	1	8	8
3	R:R:F81	R:R:N52	10.6811	6.04	Yes	No	0	8	9
4	R:R:F81	R:R:M56	17.7188	6.22	Yes	No	0	8	7
5	R:R:L74	R:R:M56	19.47	4.24	No	No	0	8	7
6	R:R:F59	R:R:L74	22.9605	4.87	No	No	0	8	8
7	R:R:F59	R:R:F71	26.4353	6.43	No	Yes	0	8	6
8	R:R:F71	R:R:M156	66.5485	6.22	Yes	No	0	6	9
9	R:R:M156	R:R:N75	71.4493	9.82	No	No	0	9	9
10	R:R:N124	R:R:N75	36.5444	12.26	No	No	0	8	9
11	R:R:N124	R:R:S120	38.0761	4.47	No	Yes	0	8	8
12	R:R:S120	R:R:S79	77.4783	4.89	Yes	No	0	8	8
13	R:R:L117	R:R:S79	78.1423	6.01	No	No	0	7	8
14	R:R:L117	R:R:V83	79.4586	4.47	No	No	0	7	9
15	R:R:V83	R:R:W402	77.6135	6.13	No	Yes	0	9	8
16	R:R:N75	R:R:W160	36.5444	11.3	No	No	0	9	9
17	R:R:S120	R:R:W160	38.0761	11.12	Yes	No	0	8	9
18	R:R:F419	R:R:L73	21.3523	6.09	Yes	No	0	9	8
19	R:R:I128	R:R:L73	22.2338	4.28	No	No	0	9	8
20	R:R:I128	R:R:Y412	23.9849	4.84	No	Yes	0	9	9
21	R:R:L76	R:R:Y412	30.8327	4.69	No	Yes	0	9	9
22	R:R:L76	R:R:N408	31.671	6.87	No	No	0	9	9
23	R:R:D80	R:R:N408	13.1941	8.08	No	No	0	9	9
24	R:R:D80	R:R:S405	13.4527	10.31	No	No	0	9	9
25	R:R:S405	R:R:V83	13.6721	4.85	No	No	0	9	9
26	R:R:F72	R:R:Q68	26.2002	7.03	Yes	No	0	9	8
27	R:R:A152	R:R:Q68	36.3975	4.55	No	No	0	8	8
28	R:R:A152	R:R:F71	38.1055	4.16	No	Yes	0	8	6
29	R:R:D131	R:R:F72	20.9802	8.36	No	Yes	0	9	9
30	R:R:D114	R:R:W110	14.0305	7.82	Yes	Yes	0	9	6
31	R:R:Y91	R:R:Y94	22.3474	8.94	Yes	No	0	8	6
32	R:R:F398	R:R:Y91	19.1389	10.32	Yes	Yes	1	7	8
33	R:R:H187	R:R:Y94	20.6433	9.8	No	No	0	3	6
34	R:R:E175	R:R:K108	16.3281	4.05	No	No	0	5	7
35	R:R:E175	R:R:E191	17.8893	5.07	No	No	1	5	8
36	R:R:E191	R:R:W174	24.4041	9.81	No	Yes	1	8	5
37	R:R:F192	R:R:W174	27.3402	9.02	Yes	Yes	1	7	5
38	R:R:F192	R:R:F193	40.0525	16.08	Yes	Yes	1	7	5
39	R:R:F193	R:R:Y115	32.5955	9.28	Yes	No	0	5	9
40	L:L:?1	R:R:Y115	26.7506	13.25	Yes	No	0	0	9
41	L:L:?1	R:R:F398	11.5429	14.45	Yes	Yes	1	0	7
42	R:R:M378	R:R:Y374	21.8283	9.58	Yes	Yes	1	8	9
43	R:R:F398	R:R:Y374	14.9335	5.16	Yes	Yes	1	7	9
44	L:L:?1	R:R:W402	73.4472	5.15	Yes	Yes	1	0	8
45	R:R:K108	R:R:L172	13.1706	4.23	No	No	0	7	5
46	R:R:L172	R:R:V112	11.539	4.47	No	No	0	5	8
47	L:L:?1	R:R:E206	48.7082	8.24	Yes	Yes	0	0	8
48	R:R:E206	R:R:Y167	10.5185	11.22	Yes	Yes	0	8	8
49	R:R:E206	R:R:W371	55.9301	7.63	Yes	Yes	0	8	8
50	R:R:L401	R:R:W371	67.3457	7.97	No	Yes	1	8	8
51	L:L:?1	R:R:L401	46.4361	9.38	Yes	No	1	0	8
52	R:R:L401	R:R:Y374	21.1604	9.38	No	Yes	1	8	9
53	R:R:N218	R:R:S129	38.1917	2.98	No	No	0	9	9
54	R:R:N218	R:R:V364	95.7926	4.43	No	No	0	9	8
55	R:R:T215	R:R:V364	97.8983	4.76	No	No	0	6	8
56	R:R:F211	R:R:T215	100	7.78	Yes	No	0	8	6
57	R:R:F207	R:R:F211	53.4758	7.5	Yes	Yes	1	9	8
58	R:R:F207	R:R:W371	61.3735	9.02	Yes	Yes	1	9	8
59	R:R:F211	R:R:F367	52.804	4.29	Yes	No	1	8	9
60	R:R:F367	R:R:W371	53.7912	13.03	No	Yes	1	9	8
61	R:R:S129	R:R:V214	11.349	8.08	No	No	0	9	9
62	R:R:F217	R:R:S129	24.8409	2.64	Yes	No	0	8	9
63	R:R:D131	R:R:Y142	17.6189	9.2	No	No	0	9	9
64	R:R:F133	R:R:F217	11.3372	12.86	No	Yes	0	9	8
65	R:R:S135	R:R:Y142	14.1049	7.63	No	No	0	9	9
66	R:R:P184	R:R:Y189	10.3363	4.17	No	No	0	3	4
67	R:R:H187	R:R:P184	12.0639	10.68	No	No	0	3	3
68	R:R:L360	R:R:N218	57.2209	5.49	Yes	No	0	8	9
69	R:R:L360	R:R:Y222	11.1022	1.17	Yes	Yes	0	8	7
70	R:R:N224	R:R:V136	10.5753	2.96	No	No	0	7	8
71	R:R:S135	R:R:V136	12.3421	3.23	No	No	0	9	8
72	R:R:D353	R:R:I225	37.9468	5.6	No	No	0	9	8
73	R:R:I221	R:R:I225	40.1602	2.94	No	No	0	9	8
74	R:R:I221	R:R:L360	42.3638	2.85	No	Yes	0	9	8
75	R:R:L233	R:R:T229	27.068	4.42	No	No	0	5	6
76	R:R:D353	R:R:T229	35.9685	8.67	No	No	0	9	6
77	R:R:L233	R:R:Q346	15.8561	5.32	No	No	0	5	5
78	R:R:Q346	R:R:S343	13.6074	10.11	No	No	0	5	3
79	R:R:S343	R:R:T345	11.349	3.2	No	No	0	3	7
80	R:R:N404	R:R:W371	24.7037	6.78	Yes	Yes	0	9	8
81	R:R:Y374	R:R:Y394	11.2178	10.92	Yes	No	0	9	4
82	R:R:R381	R:R:V389	19.8637	5.23	No	Yes	0	4	5
83	R:R:M378	R:R:R381	11.2608	6.2	Yes	No	0	8	4
84	R:R:R381	R:R:Y394	10.4029	16.46	No	No	0	4	4
85	R:R:N404	R:R:N408	22.4316	10.9	Yes	No	0	9	9
86	L:L:?1	R:R:D114	11.443	6.9	Yes	Yes	1	0	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V83	R:R:W402	6.13	0	No	Yes	9	8	2	1
R:R:C87	R:R:D114	6.22	0	No	Yes	9	9	2	1
R:R:I88	R:R:W402	9.4	0	No	Yes	9	8	2	1
R:R:W110	R:R:Y91	10.61	0	Yes	Yes	6	8	2	2
R:R:F398	R:R:Y91	10.32	1	Yes	Yes	7	8	1	2
R:R:W399	R:R:Y91	5.79	1	Yes	Yes	9	8	2	2
R:R:W402	R:R:Y91	7.72	1	Yes	Yes	8	8	1	2
R:R:D114	R:R:W110	7.82	1	Yes	Yes	9	6	1	2
R:R:D114	R:R:W402	10.05	1	Yes	Yes	9	8	1	1
L:L:?1	R:R:D114	6.9	1	Yes	Yes	0	9	0	1
R:R:Y115	R:R:Y167	6.95	0	No	Yes	9	8	1	2
R:R:F193	R:R:Y115	9.28	1	Yes	No	5	9	2	1
L:L:?1	R:R:Y115	13.25	1	Yes	No	0	9	0	1
L:L:?1	R:R:C118	5.38	1	Yes	No	0	8	0	1
R:R:E206	R:R:T119	14.11	0	Yes	No	8	9	1	2
R:R:E206	R:R:Y167	11.22	0	Yes	Yes	8	8	1	2
R:R:F193	R:R:M378	11.2	1	Yes	Yes	5	8	2	2
R:R:E206	R:R:W371	7.63	0	Yes	Yes	8	8	1	2
L:L:?1	R:R:E206	8.24	1	Yes	Yes	0	8	0	1
R:R:L401	R:R:W371	7.97	1	No	Yes	8	8	1	2
R:R:M378	R:R:Y374	9.58	1	Yes	Yes	8	9	2	1
R:R:Y374	R:R:Y394	10.92	1	Yes	No	9	4	1	2
R:R:F398	R:R:Y374	5.16	1	Yes	Yes	7	9	1	1
R:R:L401	R:R:Y374	9.38	1	No	Yes	8	9	1	1
L:L:?1	R:R:Y374	7.95	1	Yes	Yes	0	9	0	1
R:R:F398	R:R:W402	14.03	1	Yes	Yes	7	8	1	1
L:L:?1	R:R:F398	14.45	1	Yes	Yes	0	7	0	1
R:R:W399	R:R:W402	11.25	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:L401	9.38	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	5.15	1	Yes	Yes	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YUV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.15
Number of Linked Nodes	263
Number of Links	288
Number of Hubs	37
Number of Links mediated by Hubs	141
Number of Communities	6
Number of Nodes involved in Communities	39
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	103770
Length Of Smallest Path	3
Average Path Length	17.4987
Length of Longest Path	42
Minimum Path Strength	1.265
Average Path Strength	7.00438
Maximum Path Strength	18.885
Minimum Path Correlation	0.7
Average Path Correlation	0.936845
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	44.5102
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9803
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • histamine receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cellular localization • neurotransmitter secretion • transport • secretion • export from cell • neurotransmitter transport • establishment of localization • localization • signal release from synapse • secretion by cell • signal release • establishment of localization in cell • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • presynapse • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5N1
Sequence	>8YUV_nogp_Chain_R A W T A V L A A L M A L L I V A T V L G N A L V M L A F V A D S S L R T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R W T F G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R A V S Y R A Q Q G D T R R A V R K M L L V W V L A F L L Y G P A I L S W E Y L S G G S S I P E G H C Y A E F F Y N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G S F T Q R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C H G H C V P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F R R A F T K L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR0	Na	-	1.71	2025-06-18	To be published
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8TH3	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	AT118-H Nanobody	-	3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	9JH3	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	8YUV	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-	Gi1/β1/γ2	3	2024-06-05	doi.org/10.1002/advs.202310120
	8YUV (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-		3	2024-06-05	doi.org/10.1002/advs.202310120
	7F61	A	Amine	Histamine	H₃	Homo sapiens	PF-03654746	-	-	2.6	2022-10-26	doi.org/10.1038/s41467-022-33880-y
	8YN7	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN7 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YUU	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ1	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUU (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YN5	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-	Gi1/β1/γ2	2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-		2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb

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