psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T34	R:R:W33	6.06	No	No	0	5	3
2	R:R:M41	R:R:V92	4.56	No	No	0	7	7
3	R:R:M41	R:R:V95	4.56	No	No	0	7	6
4	R:R:L50	R:R:V46	4.47	No	No	0	5	5
5	R:R:G84	R:R:T48	5.46	No	No	0	9	9
6	R:R:D80	R:R:N52	12.12	Yes	No	0	9	9
7	R:R:F81	R:R:N52	3.62	Yes	No	0	8	9
8	R:R:N52	R:R:P409	11.4	No	No	0	9	9
9	R:R:F423	R:R:L54	3.65	Yes	Yes	0	9	8
10	R:R:P413	R:R:V55	7.07	No	No	0	9	9
11	R:R:F81	R:R:M56	6.22	Yes	No	0	8	7
12	R:R:A58	R:R:F423	4.16	No	Yes	0	9	9
13	R:R:F59	R:R:R66	14.97	No	No	0	8	8
14	R:R:F59	R:R:F71	9.65	No	Yes	0	8	6
15	R:R:F59	R:R:L74	14.61	No	No	0	8	8
16	R:R:A61	R:R:L426	4.73	No	No	0	7	8
17	R:R:D62	R:R:S64	10.31	Yes	No	0	8	7
18	R:R:D62	R:R:L65	5.43	Yes	No	0	8	9
19	R:R:A422	R:R:D62	4.63	No	Yes	0	9	8
20	R:R:L65	R:R:N70	4.12	No	Yes	2	9	9
21	R:R:F419	R:R:L65	4.87	Yes	No	2	9	9
22	R:R:N70	R:R:T67	7.31	Yes	No	0	9	8
23	R:R:Q146	R:R:T67	4.25	No	No	0	8	8
24	R:R:D148	R:R:Q68	3.92	No	No	4	8	8
25	R:R:Q68	R:R:R151	5.84	No	Yes	4	8	7
26	R:R:D131	R:R:N69	8.08	No	No	0	9	8
27	R:R:H416	R:R:N69	5.1	Yes	No	0	9	8
28	R:R:H416	R:R:N70	7.65	Yes	Yes	2	9	9
29	R:R:N70	R:R:S418	4.47	Yes	No	2	9	8
30	R:R:F419	R:R:N70	8.46	Yes	Yes	2	9	9
31	R:R:F71	R:R:T149	3.89	Yes	No	0	6	6
32	R:R:A152	R:R:F71	4.16	No	Yes	0	8	6
33	R:R:F71	R:R:M156	4.98	Yes	No	0	6	9
34	R:R:F72	R:R:L127	19.49	Yes	No	4	9	8
35	R:R:D131	R:R:F72	5.97	No	Yes	0	9	9
36	R:R:F72	R:R:K155	6.2	Yes	No	4	9	7
37	R:R:L73	R:R:Y412	3.52	No	Yes	2	8	9
38	R:R:H416	R:R:L73	5.14	Yes	No	2	9	8
39	R:R:F419	R:R:L73	7.31	Yes	No	2	9	8
40	R:R:I78	R:R:L74	5.71	No	No	0	8	8
41	R:R:N124	R:R:N75	12.26	No	No	0	8	9
42	R:R:M156	R:R:N75	15.43	No	No	0	9	9
43	R:R:N75	R:R:W160	13.56	No	Yes	0	9	9
44	R:R:D80	R:R:L76	4.07	Yes	Yes	2	9	9
45	R:R:L76	R:R:N124	4.12	Yes	No	0	9	8
46	R:R:L76	R:R:N408	5.49	Yes	No	2	9	9
47	R:R:L76	R:R:Y412	3.52	Yes	Yes	2	9	9
48	R:R:S120	R:R:S79	6.52	No	No	7	8	8
49	R:R:S79	R:R:W160	7.41	No	Yes	7	8	9
50	R:R:D80	R:R:S121	4.42	Yes	No	0	9	9
51	R:R:D80	R:R:S405	5.89	Yes	No	0	9	9
52	R:R:D80	R:R:N408	12.12	Yes	No	2	9	9
53	R:R:L117	R:R:L82	5.54	No	No	0	7	6
54	R:R:L117	R:R:V83	5.96	No	No	0	7	9
55	R:R:V83	R:R:W402	4.9	No	Yes	0	9	8
56	R:R:G84	R:R:I88	3.53	No	Yes	0	9	9
57	R:R:F86	R:R:L90	3.65	No	No	0	6	6
58	R:R:F86	R:R:V113	10.49	No	No	0	6	6
59	R:R:C87	R:R:D114	7.78	No	Yes	0	9	9
60	R:R:I88	R:R:P89	6.77	Yes	No	0	9	9
61	R:R:I88	R:R:W402	10.57	Yes	Yes	0	9	8
62	R:R:L90	R:R:W100	7.97	No	Yes	1	6	9
63	R:R:L90	R:R:W110	6.83	No	Yes	1	6	6
64	R:R:Y91	R:R:Y94	5.96	Yes	No	0	8	6
65	R:R:V95	R:R:Y91	7.57	No	Yes	0	6	8
66	R:R:W110	R:R:Y91	9.65	Yes	Yes	1	6	8
67	R:R:E395	R:R:Y91	7.86	No	Yes	1	6	8
68	R:R:F398	R:R:Y91	10.32	Yes	Yes	1	7	8
69	R:R:W399	R:R:Y91	7.72	Yes	Yes	1	9	8
70	R:R:W402	R:R:Y91	6.75	Yes	Yes	1	8	8
71	R:R:P93	R:R:V92	3.53	No	No	0	7	7
72	R:R:W100	R:R:Y94	5.79	Yes	No	0	9	6
73	R:R:H187	R:R:Y94	10.89	Yes	No	0	3	6
74	R:R:E185	R:R:R99	10.47	No	No	0	1	4
75	R:R:W100	R:R:W110	8.43	Yes	Yes	1	9	6
76	R:R:C188	R:R:W100	13.06	No	Yes	0	9	9
77	R:R:F102	R:R:T101	3.89	No	No	0	8	5
78	R:R:F102	R:R:L106	4.87	No	No	0	8	5
79	R:R:I183	R:R:R104	11.27	No	No	0	4	4
80	R:R:C107	R:R:C188	7.28	No	No	0	9	9
81	R:R:K108	R:R:L172	4.23	No	No	0	7	5
82	R:R:E175	R:R:K108	9.45	No	No	0	5	7
83	R:R:K108	R:R:Y176	4.78	No	No	0	7	5
84	R:R:L111	R:R:W110	5.69	No	Yes	0	7	6
85	R:R:I171	R:R:L111	5.71	Yes	No	0	7	7
86	R:R:L172	R:R:V112	4.47	No	No	0	5	8
87	R:R:C118	R:R:D114	4.67	No	Yes	1	8	9
88	R:R:D114	R:R:W402	7.82	Yes	Yes	1	9	8
89	L:L:?1	R:R:D114	11.5	Yes	Yes	1	0	9
90	R:R:Y115	R:R:Y167	15.89	Yes	Yes	0	9	8
91	R:R:I171	R:R:Y115	6.04	Yes	Yes	0	7	9
92	R:R:F193	R:R:Y115	6.19	No	Yes	0	5	9
93	L:L:?1	R:R:Y115	7.72	Yes	Yes	0	0	9
94	R:R:L116	R:R:W160	6.83	No	Yes	0	8	9
95	L:L:?1	R:R:C118	8.96	Yes	No	1	0	8
96	R:R:F123	R:R:T119	6.49	No	No	0	7	9
97	R:R:E206	R:R:T119	8.47	No	No	0	8	9
98	R:R:S120	R:R:W160	8.65	No	Yes	7	8	9
99	R:R:A122	R:R:W371	3.89	No	Yes	0	9	8
100	R:R:F123	R:R:V159	3.93	No	No	0	7	8
101	R:R:N124	R:R:V159	5.91	No	No	0	8	8
102	R:R:F367	R:R:I125	5.02	No	No	0	9	8
103	R:R:I125	R:R:Y412	8.46	No	Yes	0	8	9
104	R:R:S213	R:R:V126	6.46	No	No	0	8	8
105	R:R:K155	R:R:L127	4.23	No	No	4	7	8
106	R:R:I128	R:R:R132	5.01	No	No	2	9	9
107	R:R:I128	R:R:Y412	4.84	No	Yes	2	9	9
108	R:R:S129	R:R:V214	8.08	No	No	0	9	9
109	R:R:L134	R:R:Y130	15.24	No	No	0	5	7
110	R:R:F217	R:R:Y130	6.19	Yes	No	0	8	7
111	R:R:D131	R:R:Y142	11.49	No	No	0	9	9
112	R:R:R132	R:R:Y412	5.14	No	Yes	2	9	9
113	R:R:F133	R:R:T137	7.78	No	No	0	9	8
114	R:R:F133	R:R:F217	13.93	No	Yes	0	9	8
115	R:R:F133	R:R:S220	5.28	No	No	0	9	8
116	R:R:L134	R:R:R138	3.64	No	No	0	5	6
117	R:R:S135	R:R:Y142	8.9	No	No	0	9	9
118	R:R:Q145	R:R:R151	9.35	No	Yes	0	6	7
119	R:R:D148	R:R:R151	13.1	No	Yes	4	8	7
120	R:R:R150	R:R:R151	13.86	No	Yes	0	7	7
121	R:R:R150	R:R:R154	9.6	No	No	0	7	3
122	R:R:L158	R:R:L162	6.92	No	No	0	4	6
123	R:R:L166	R:R:Y167	7.03	No	Yes	0	8	8
124	R:R:F192	R:R:Y167	4.13	Yes	Yes	5	7	8
125	R:R:F198	R:R:Y167	4.13	Yes	Yes	5	7	8
126	R:R:A202	R:R:Y167	5.34	No	Yes	0	9	8
127	R:R:E206	R:R:Y167	11.22	No	Yes	0	8	8
128	R:R:G168	R:R:P169	4.06	No	No	0	6	8
129	R:R:G168	R:R:I171	3.53	No	Yes	0	6	7
130	R:R:A170	R:R:F198	4.16	No	Yes	0	8	7
131	R:R:S178	R:R:W174	6.18	No	Yes	0	3	5
132	R:R:E191	R:R:W174	8.72	No	Yes	0	8	5
133	R:R:F192	R:R:W174	5.01	Yes	Yes	5	7	5
134	R:R:F198	R:R:W174	7.02	Yes	Yes	5	7	5
135	R:R:H187	R:R:P184	9.15	Yes	No	0	3	3
136	R:R:H187	R:R:Y189	7.62	Yes	No	0	3	4
137	R:R:Y189	R:R:Y194	6.95	No	No	0	4	6
138	R:R:A190	R:R:F192	8.32	No	Yes	0	7	7
139	R:R:F192	R:R:F193	5.36	Yes	No	0	7	5
140	R:R:F192	R:R:F198	16.08	Yes	Yes	5	7	7
141	R:R:F193	R:R:R381	6.41	No	Yes	0	5	4
142	R:R:N195	R:R:Y197	5.81	No	No	0	6	5
143	R:R:W196	R:R:Y197	27.97	No	No	0	5	5
144	R:R:I200	R:R:W196	5.87	No	No	0	7	5
145	R:R:A383	R:R:W196	3.89	No	No	0	5	5
146	R:R:I200	R:R:I379	4.42	No	No	0	7	6
147	R:R:S203	R:R:T375	4.8	No	No	0	8	8
148	R:R:I379	R:R:S203	4.64	No	No	0	6	8
149	R:R:F208	R:R:T204	3.89	No	No	0	7	6
150	R:R:E206	R:R:W371	5.45	No	Yes	0	8	8
151	R:R:F207	R:R:F208	6.43	Yes	No	0	9	7
152	R:R:F207	R:R:F211	6.43	Yes	Yes	0	9	8
153	R:R:F207	R:R:F367	4.29	Yes	No	1	9	9
154	R:R:F207	R:R:W371	8.02	Yes	Yes	1	9	8
155	R:R:F207	R:R:T375	3.89	Yes	No	0	9	8
156	R:R:F211	R:R:T215	6.49	Yes	No	0	8	6
157	R:R:F211	R:R:G368	4.52	Yes	No	0	8	7
158	R:R:F217	R:R:S213	5.28	Yes	No	0	8	8
159	R:R:N218	R:R:V214	4.43	No	No	0	9	9
160	R:R:F216	R:R:F217	6.43	No	Yes	0	5	8
161	R:R:F216	R:R:S220	7.93	No	No	0	5	8
162	R:R:L360	R:R:N218	9.61	No	No	0	8	9
163	R:R:N218	R:R:V364	5.91	No	No	0	9	8
164	R:R:Q226	R:R:Y222	16.91	No	No	0	7	7
165	R:R:N224	R:R:R227	6.03	No	No	0	7	5
166	R:R:D353	R:R:I225	5.6	No	No	0	9	8
167	R:R:D353	R:R:Q226	3.92	No	No	0	9	7
168	R:R:R227	R:R:R228	4.26	No	No	0	5	8
169	R:R:R349	R:R:T229	11.64	No	Yes	0	6	6
170	R:R:D353	R:R:T229	7.23	No	Yes	0	9	6
171	R:R:R232	R:R:R349	6.4	No	No	0	5	6
172	R:R:L233	R:R:Q346	3.99	No	No	0	5	5
173	R:R:Q346	R:R:S343	10.11	No	No	0	5	3
174	R:R:F348	R:R:R352	8.55	No	No	0	4	8
175	R:R:K355	R:R:R352	9.9	No	No	0	8	8
176	R:R:I363	R:R:L411	5.71	No	No	0	8	9
177	R:R:I363	R:R:Y412	8.46	No	Yes	0	8	9
178	R:R:I366	R:R:L411	8.56	No	No	0	7	9
179	R:R:F367	R:R:W371	7.02	No	Yes	1	9	8
180	R:R:C370	R:R:L400	6.35	No	No	0	8	9
181	R:R:C370	R:R:N404	9.45	No	No	0	8	9
182	R:R:L401	R:R:W371	13.67	No	Yes	1	8	8
183	R:R:N404	R:R:W371	7.91	No	Yes	0	9	8
184	R:R:L400	R:R:P373	4.93	No	No	0	9	9
185	R:R:M378	R:R:Y374	4.79	No	Yes	0	8	9
186	R:R:S397	R:R:Y374	8.9	No	Yes	0	7	9
187	R:R:L401	R:R:Y374	8.21	No	Yes	1	8	9
188	L:L:?1	R:R:Y374	8.83	Yes	Yes	1	0	9
189	R:R:L377	R:R:R381	3.64	No	Yes	3	7	4
190	R:R:L377	R:R:V389	8.94	No	Yes	3	7	5
191	R:R:L377	R:R:S397	6.01	No	No	0	7	7
192	R:R:R381	R:R:V389	9.15	Yes	Yes	3	4	5
193	R:R:R381	R:R:Y394	15.43	Yes	No	0	4	4
194	R:R:C384	R:R:C388	7.28	No	Yes	3	7	8
195	R:R:P390	R:R:V389	3.53	No	Yes	3	7	5
196	R:R:P390	R:R:Y392	13.91	No	No	3	7	3
197	R:R:P390	R:R:W393	21.62	No	No	3	7	6
198	R:R:W393	R:R:Y392	7.72	No	No	3	6	3
199	R:R:E395	R:R:W399	8.72	No	Yes	1	6	9
200	R:R:F398	R:R:W399	4.01	Yes	Yes	1	7	9
201	R:R:F398	R:R:W402	12.03	Yes	Yes	1	7	8
202	L:L:?1	R:R:F398	24.07	Yes	Yes	1	0	7
203	R:R:W399	R:R:W402	11.25	Yes	Yes	1	9	8
204	L:L:?1	R:R:L401	9.12	Yes	No	1	0	8
205	L:L:?1	R:R:W402	10.72	Yes	Yes	1	0	8
206	R:R:N404	R:R:N408	8.17	No	No	0	9	9
207	R:R:L414	R:R:V410	4.47	No	No	0	7	7
208	R:R:P413	R:R:Y412	4.17	No	Yes	0	9	9
209	R:R:F423	R:R:L414	3.65	Yes	No	0	9	7
210	R:R:H416	R:R:S418	9.76	Yes	No	2	9	8
211	R:R:F419	R:R:H416	7.92	Yes	Yes	2	9	9
212	R:R:K425	R:R:R421	4.95	No	No	0	6	6
213	R:R:F72	R:R:Q68	3.51	Yes	No	4	9	8
214	R:R:P210	R:R:T209	3.5	No	No	0	9	7
215	R:R:L37	R:R:W33	3.42	No	No	0	5	3
216	R:R:L106	R:R:W100	3.42	No	Yes	0	5	9
217	R:R:A77	R:R:V55	3.39	No	No	0	9	9
218	R:R:I183	R:R:P184	3.39	No	No	0	4	3
219	R:R:A163	R:R:T119	3.36	No	No	0	8	9
220	R:R:E175	R:R:G180	3.27	No	No	0	5	2
221	R:R:S135	R:R:V136	3.23	No	No	0	9	8
222	R:R:F419	R:R:F423	3.22	Yes	Yes	0	9	9
223	R:R:V126	R:R:V214	3.21	No	No	0	8	9
224	R:R:S343	R:R:T345	3.2	No	No	0	3	7
225	R:R:T215	R:R:V364	3.17	No	No	0	6	8
226	R:R:A38	R:R:L96	3.15	No	No	0	6	7
227	R:R:I171	R:R:V112	3.07	Yes	No	0	7	8
228	R:R:I366	R:R:V362	3.07	No	No	0	7	8
229	R:R:L50	R:R:V49	2.98	No	No	0	5	7
230	R:R:L96	R:R:V92	2.98	No	No	0	7	7
231	R:R:L109	R:R:V113	2.98	No	No	0	6	6
232	R:R:L157	R:R:V153	2.98	No	No	0	5	5
233	R:R:L165	R:R:V161	2.98	No	No	0	5	5
234	R:R:L360	R:R:V356	2.98	No	No	0	8	8
235	R:R:L44	R:R:T48	2.95	No	No	0	7	9
236	R:R:L233	R:R:T229	2.95	No	Yes	0	5	6
237	R:R:I45	R:R:I88	2.94	No	Yes	0	7	9
238	R:R:I221	R:R:I225	2.94	No	No	0	9	8
239	R:R:F164	R:R:P169	2.89	No	No	0	7	8
240	R:R:I221	R:R:L360	2.85	No	No	0	9	8
241	R:R:L199	R:R:M378	2.83	No	No	0	8	8
242	R:R:G103	R:R:W100	2.81	No	Yes	0	8	9
243	R:R:H417	R:R:S418	2.79	No	No	0	5	8
244	R:R:A53	R:R:F81	2.77	No	Yes	0	6	8
245	R:R:L166	R:R:L205	2.77	No	No	0	8	6
246	R:R:A372	R:R:F207	2.77	No	Yes	0	7	9
247	R:R:L219	R:R:L223	2.77	No	No	0	4	5
248	R:R:A357	R:R:Y222	2.67	No	No	0	8	7
249	R:R:R104	R:R:S181	2.64	No	No	0	4	4
250	R:R:R138	R:R:S141	2.64	No	No	0	6	5
251	R:R:F81	R:R:V49	2.62	Yes	No	0	8	7
252	R:R:R143	R:R:V140	2.62	No	No	0	7	7
253	R:R:A32	R:R:W33	2.59	No	No	0	4	3
254	R:R:F123	R:R:L162	2.44	No	No	0	7	6
255	R:R:F164	R:R:L165	2.44	No	No	0	7	5
256	R:R:F208	R:R:L376	2.44	No	No	0	7	7
257	R:R:L223	R:R:Y222	2.34	No	No	0	5	7
258	R:R:H187	R:R:R99	2.26	Yes	No	0	3	4
259	R:R:H417	R:R:R421	2.26	No	No	0	5	6
260	R:R:G179	R:R:G180	2.11	No	No	0	5	2
261	R:R:G98	R:R:T97	1.82	No	No	0	7	5
262	R:R:P210	R:R:S213	1.78	No	No	0	9	8
263	R:R:G51	R:R:L50	1.71	No	No	0	9	5
264	R:R:G51	R:R:L54	1.71	No	Yes	0	9	8
265	R:R:C388	R:R:V389	1.71	Yes	Yes	3	8	5
266	R:R:A85	R:R:V49	1.7	No	No	0	6	7
267	R:R:A406	R:R:T48	1.68	No	No	0	7	9
268	R:R:D234	R:R:G235	1.68	No	No	0	4	4
269	R:R:E185	R:R:G186	1.64	No	No	0	1	3
270	R:R:C384	R:R:I380	1.64	No	No	3	7	7
271	R:R:C388	R:R:I380	1.64	Yes	No	3	8	7
272	R:R:V407	R:R:V410	1.6	No	No	0	7	7
273	R:R:C370	R:R:L369	1.59	No	No	0	8	5
274	R:R:A382	R:R:L199	1.58	No	No	0	7	8
275	R:R:A403	R:R:L400	1.58	No	No	0	7	9
276	R:R:I363	R:R:S359	1.55	No	No	0	8	9
277	R:R:A144	R:R:Q145	1.52	No	No	0	5	6
278	R:R:M156	R:R:V153	1.52	No	No	0	9	5
279	R:R:K355	R:R:V356	1.52	No	No	0	8	8
280	R:R:L172	R:R:S173	1.5	No	No	0	5	6
281	R:R:N224	R:R:V136	1.48	No	No	0	7	8
282	R:R:D62	R:R:S63	1.47	Yes	No	0	8	8
283	R:R:L205	R:R:T201	1.47	No	No	0	6	6
284	R:R:L350	R:R:T229	1.47	No	Yes	0	6	6
285	R:R:C384	R:R:H387	1.47	No	No	3	7	4
286	R:R:C388	R:R:H387	1.47	Yes	No	3	8	4
287	R:R:K355	R:R:K358	1.44	No	No	0	8	7
288	R:R:C415	R:R:R420	1.39	No	No	0	8	9
289	R:R:L40	R:R:L43	1.38	No	No	0	5	4
290	R:R:L54	R:R:L57	1.38	Yes	No	6	8	7
291	R:R:L426	R:R:L54	1.38	No	Yes	6	8	8
292	R:R:L426	R:R:L57	1.38	No	No	6	8	7
293	R:R:R99	R:R:T97	1.29	No	No	0	4	5
294	R:R:F211	R:R:L212	1.22	Yes	No	0	8	5
295	R:R:L231	R:R:R227	1.21	No	No	0	5	5
296	R:R:Q226	R:R:R230	1.17	No	No	0	7	6
297	R:R:F344	R:R:R347	1.07	No	No	0	4	5
298	R:R:F344	R:R:F348	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L54	2.03	4	6	8
2	R:R:D62	5.46	4	0	8
3	R:R:N70	6.402	5	2	9
4	R:R:F71	5.67	4	0	6
5	R:R:F72	8.7925	4	4	9
6	R:R:L76	4.3	4	2	9
7	R:R:D80	7.724	5	2	9
8	R:R:F81	3.8075	4	0	8
9	R:R:I88	5.9525	4	0	9
10	R:R:Y91	7.97571	7	1	8
11	R:R:W100	6.91333	6	1	9
12	R:R:W110	7.65	4	1	6
13	R:R:D114	7.9425	4	1	9
14	R:R:Y115	8.96	4	0	9
15	R:R:R151	10.5375	4	4	7
16	R:R:W160	9.1125	4	7	9
17	R:R:Y167	7.95667	6	5	8
18	R:R:I171	4.5875	4	0	7
19	R:R:W174	6.7325	4	5	5
20	R:R:H187	7.48	4	0	3
21	R:R:F192	7.78	5	5	7
22	R:R:F198	7.8475	4	5	7
23	R:R:F207	5.305	6	1	9
24	R:R:F211	4.665	4	0	8
25	R:R:F217	7.9575	4	0	8
26	R:R:T229	5.8225	4	0	6
27	R:R:W371	7.66	6	1	8
28	R:R:Y374	7.6825	4	1	9
29	R:R:R381	8.6575	4	3	4
30	R:R:C388	3.025	4	3	8
31	R:R:V389	5.8325	4	3	5
32	R:R:F398	12.6075	4	1	7
33	R:R:W399	7.925	4	1	9
34	R:R:W402	9.14857	7	1	8
35	R:R:Y412	5.44429	7	2	9
36	R:R:H416	7.114	5	2	9
37	R:R:F419	6.356	5	2	9
38	R:R:F423	3.67	4	0	9
39	L:L:?1	11.56	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F81	R:R:N52	10.8795	3.62	Yes	No	0	8	9
2	R:R:D80	R:R:N52	13.7328	12.12	Yes	No	0	9	9
3	R:R:D80	R:R:N408	14.4323	12.12	Yes	No	2	9	9
4	R:R:N404	R:R:N408	31.6904	8.17	No	No	0	9	9
5	R:R:N404	R:R:W371	35.9427	7.91	No	Yes	0	9	8
6	R:R:L401	R:R:W371	100	13.67	No	Yes	1	8	8
7	L:L:?1	R:R:L401	88.0528	9.12	Yes	No	1	0	8
8	L:L:?1	R:R:F398	39.155	24.07	Yes	Yes	1	0	7
9	R:R:F398	R:R:Y91	36.1222	10.32	Yes	Yes	1	7	8
10	R:R:V95	R:R:Y91	13.8985	7.57	No	Yes	0	6	8
11	R:R:M41	R:R:V95	11.5744	4.56	No	No	0	7	6
12	L:L:?1	R:R:W402	49.878	10.72	Yes	Yes	1	0	8
13	R:R:W402	R:R:Y91	38.5061	6.75	Yes	Yes	1	8	8
14	R:R:F419	R:R:F423	15.7577	3.22	Yes	Yes	0	9	9
15	R:R:F419	R:R:L73	25.2612	7.31	Yes	No	2	9	8
16	R:R:L73	R:R:Y412	62.29	3.52	No	Yes	2	8	9
17	R:R:I125	R:R:Y412	68.8389	8.46	No	Yes	0	8	9
18	R:R:F367	R:R:I125	69.5476	5.02	No	No	0	9	8
19	R:R:F367	R:R:W371	49.0819	7.02	No	Yes	1	9	8
20	R:R:F71	R:R:M156	12.8492	4.98	Yes	No	0	6	9
21	R:R:M156	R:R:N75	18.2199	15.43	No	No	0	9	9
22	R:R:N124	R:R:N75	26.987	12.26	No	No	0	8	9
23	R:R:L76	R:R:N124	25.4683	4.12	Yes	No	0	9	8
24	R:R:L76	R:R:N408	16.5493	5.49	Yes	No	2	9	9
25	R:R:H416	R:R:L73	35.9059	5.14	Yes	No	2	9	8
26	R:R:F72	R:R:Q68	10.7828	3.51	Yes	No	4	9	8
27	R:R:D131	R:R:F72	15.2653	5.97	No	Yes	0	9	9
28	R:R:D131	R:R:N69	26.7154	8.08	No	No	0	9	8
29	R:R:H416	R:R:N69	28.1099	5.1	Yes	No	0	9	8
30	R:R:W110	R:R:Y91	21.4276	9.65	Yes	Yes	1	6	8
31	R:R:Y91	R:R:Y94	40.416	5.96	Yes	No	0	8	6
32	R:R:W100	R:R:Y94	13.199	5.79	Yes	No	0	9	6
33	R:R:W100	R:R:W110	14.8189	8.43	Yes	Yes	1	9	6
34	R:R:H187	R:R:Y94	28.1283	10.89	Yes	No	0	3	6
35	R:R:H187	R:R:R99	11.938	2.26	Yes	No	0	3	4
36	R:R:L106	R:R:W100	11.22	3.42	No	Yes	0	5	9
37	R:R:L172	R:R:V112	13.5487	4.47	No	No	0	5	8
38	R:R:I171	R:R:V112	15.3758	3.07	Yes	No	0	7	8
39	L:L:?1	R:R:Y115	25.3762	7.72	Yes	Yes	0	0	9
40	R:R:Y115	R:R:Y167	25.0863	15.89	Yes	Yes	0	9	8
41	R:R:F123	R:R:T119	10.6217	6.49	No	No	0	7	9
42	R:R:E206	R:R:T119	12.9136	8.47	No	No	0	8	9
43	R:R:E206	R:R:Y167	33.1032	11.22	No	Yes	0	8	8
44	R:R:E206	R:R:W371	29.693	5.45	No	Yes	0	8	8
45	R:R:F207	R:R:W371	59.9797	8.02	Yes	Yes	1	9	8
46	R:R:F207	R:R:F211	66.3905	6.43	Yes	Yes	0	9	8
47	R:R:F211	R:R:T215	62.7456	6.49	Yes	No	0	8	6
48	R:R:T215	R:R:V364	61.5123	3.17	No	No	0	6	8
49	R:R:N218	R:R:V364	60.2697	5.91	No	No	0	9	8
50	R:R:N218	R:R:V214	24.9574	4.43	No	No	0	9	9
51	R:R:V126	R:R:V214	21.966	3.21	No	No	0	8	9
52	R:R:S213	R:R:V126	20.4565	6.46	No	No	0	8	8
53	R:R:F217	R:R:S213	15.8728	5.28	Yes	No	0	8	8
54	R:R:D131	R:R:Y142	10.6632	11.49	No	No	0	9	9
55	R:R:F193	R:R:Y115	12.1773	6.19	No	Yes	0	5	9
56	R:R:F193	R:R:R381	11.3535	6.41	No	Yes	0	5	4
57	R:R:F207	R:R:T375	12.771	3.89	Yes	No	0	9	8
58	R:R:S203	R:R:T375	11.2062	4.8	No	No	0	8	8
59	R:R:L360	R:R:N218	37.7376	9.61	No	No	0	8	9
60	R:R:I221	R:R:L360	26.3151	2.85	No	No	0	9	8
61	R:R:I221	R:R:I225	24.8378	2.94	No	No	0	9	8
62	R:R:D353	R:R:I225	23.3375	5.6	No	No	0	9	8
63	R:R:D353	R:R:T229	12.7479	7.23	No	Yes	0	9	6
64	R:R:L360	R:R:V356	11.082	2.98	No	No	0	8	8
65	R:R:S397	R:R:Y374	12.2785	8.9	No	Yes	0	7	9
66	R:R:L377	R:R:S397	11.0129	6.01	No	No	0	7	7
67	R:R:L76	R:R:Y412	15.1088	3.52	Yes	Yes	2	9	9
68	R:R:I171	R:R:Y115	28.0317	6.04	Yes	Yes	0	7	9
69	R:R:L401	R:R:Y374	11.8229	8.21	No	Yes	1	8	9
70	R:R:F207	R:R:F367	21.2435	4.29	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V83	R:R:W402	4.9	0	No	Yes	9	8	2	1
R:R:C87	R:R:D114	7.78	0	No	Yes	9	9	2	1
R:R:I88	R:R:W402	10.57	0	Yes	Yes	9	8	2	1
R:R:F398	R:R:Y91	10.32	1	Yes	Yes	7	8	1	2
R:R:W399	R:R:Y91	7.72	1	Yes	Yes	9	8	2	2
R:R:W402	R:R:Y91	6.75	1	Yes	Yes	8	8	1	2
R:R:C118	R:R:D114	4.67	1	No	Yes	8	9	1	1
R:R:D114	R:R:W402	7.82	1	Yes	Yes	9	8	1	1
L:L:?1	R:R:D114	11.5	1	Yes	Yes	0	9	0	1
R:R:Y115	R:R:Y167	15.89	0	Yes	Yes	9	8	1	2
R:R:I171	R:R:Y115	6.04	0	Yes	Yes	7	9	2	1
R:R:F193	R:R:Y115	6.19	0	No	Yes	5	9	2	1
L:L:?1	R:R:Y115	7.72	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:C118	8.96	1	Yes	No	0	8	0	1
R:R:L401	R:R:W371	13.67	1	No	Yes	8	8	1	2
R:R:M378	R:R:Y374	4.79	0	No	Yes	8	9	2	1
R:R:S397	R:R:Y374	8.9	0	No	Yes	7	9	2	1
R:R:L401	R:R:Y374	8.21	1	No	Yes	8	9	1	1
L:L:?1	R:R:Y374	8.83	1	Yes	Yes	0	9	0	1
R:R:F398	R:R:W399	4.01	1	Yes	Yes	7	9	1	2
R:R:F398	R:R:W402	12.03	1	Yes	Yes	7	8	1	1
L:L:?1	R:R:F398	24.07	1	Yes	Yes	0	7	0	1
R:R:W399	R:R:W402	11.25	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:L401	9.12	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	10.72	1	Yes	Yes	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YUU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	269
Number of Links	298
Number of Hubs	39
Number of Links mediated by Hubs	148
Number of Communities	7
Number of Nodes involved in Communities	54
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	50683
Length Of Smallest Path	3
Average Path Length	12.7672
Length of Longest Path	27
Minimum Path Strength	1.07
Average Path Strength	7.16674
Maximum Path Strength	17.785
Minimum Path Correlation	0.7
Average Path Correlation	0.931615
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	53.6878
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.2227
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cellular localization • neurotransmitter secretion • transport • secretion • export from cell • neurotransmitter transport • establishment of localization • localization • signal release from synapse • secretion by cell • signal release • establishment of localization in cell • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • presynapse • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	4-imidazoleethylamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5N1
Sequence	>8YUU_nogp_Chain_R A W T A V L A A L M A L L I V A T V L G N A L V M L A F V A D S S L R T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R W T F G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R A V S Y R A Q Q G D T R R A V R K M L L V W V L A F L L Y G P A I L S W E Y L S G G S S I P E G H C Y A E F F Y N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G S F T Q R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C H G H C V P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F R R A F T K L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ	2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	10.2210/pdb8YN7/pdb
	8YN8	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-	Go1/β1/γ2	2.77	2024-10-16	10.2210/pdb8YN7/pdb
	8YN8 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-		2.77	2024-10-16	10.2210/pdb8YN7/pdb
	8YN7	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-	Go1/β1/γ2	2.77	2024-10-16	10.2210/pdb8YN7/pdb
	8YN7 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-		2.77	2024-10-16	10.2210/pdb8YN7/pdb
	8YN6	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-	Gi1/β1/γ2	2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-		2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YUU	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ1	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUU (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8TH3	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	AT118-H Nanobody	-	3	2024-05-22	10.1038/s41589-024-01620-6
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	10.1126/sciadv.adk4855
	8YUV	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-	Gi1/β1/γ2	3	2024-06-05	10.1002/advs.202310120
	8YUV (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-		3	2024-06-05	10.1002/advs.202310120
	7F61	A	Amine	Histamine	H₃	Homo sapiens	PF-03654746	Cholesterol	-	2.6	2022-10-26	10.1038/s41467-022-33880-y

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