psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:K25	S:S:K271	4.31	Yes	Yes	9	4	3
2	M:M:F34	S:S:K25	3.72	No	Yes	9	6	4
3	M:M:V70	S:S:K25	3.04	No	Yes	0	9	4
4	S:S:E26	S:S:P27	7.86	No	No	0	2	5
5	S:S:E26	S:S:F29	23.32	No	No	0	2	4
6	M:M:C71	S:S:P27	3.77	No	No	0	9	5
7	S:S:C28	S:S:R30	4.18	No	No	0	9	5
8	M:M:P31	S:S:C28	3.77	No	No	0	7	9
9	M:M:R29	S:S:R30	3.2	Yes	No	0	9	5
10	S:S:E32	S:S:N278	15.77	No	No	0	4	3
11	R:R:E275	S:S:N33	3.94	No	No	0	3	6
12	S:S:A34	S:S:K282	3.21	No	No	0	1	2
13	R:R:E275	S:S:N35	5.26	No	No	0	3	3
14	R:R:F276	S:S:N35	8.46	Yes	No	0	1	3
15	R:R:T279	S:S:N35	7.31	No	No	0	2	3
16	S:S:F36	S:S:F40	7.5	No	No	0	4	5
17	R:R:W283	S:S:F36	3.01	Yes	No	0	6	4
18	S:S:I286	S:S:N37	4.25	No	Yes	0	6	3
19	R:R:Q272	S:S:K38	8.14	No	No	0	2	4
20	R:R:W283	S:S:I39	15.27	Yes	No	0	6	5
21	S:S:F40	S:S:I44	10.05	No	No	0	5	5
22	S:S:L41	S:S:Y45	5.86	No	Yes	0	6	7
23	S:S:A289	S:S:L41	3.15	No	No	0	4	6
24	S:S:P42	S:S:V99	5.3	No	No	17	5	4
25	R:R:I261	S:S:P42	3.39	No	No	17	5	5
26	R:R:P254	S:S:T43	3.5	No	No	0	9	4
27	R:R:I257	S:S:T43	4.56	No	No	0	6	4
28	R:R:W283	S:S:T43	7.28	Yes	No	0	6	4
29	S:S:I44	S:S:I48	2.94	No	No	0	5	7
30	S:S:L91	S:S:Y45	4.69	Yes	Yes	0	8	7
31	S:S:W94	S:S:Y45	2.89	Yes	Yes	0	7	7
32	S:S:A95	S:S:Y45	4	No	Yes	0	7	7
33	S:S:F292	S:S:Y45	7.22	No	Yes	0	7	7
34	R:R:I257	S:S:S46	6.19	No	No	0	6	5
35	R:R:L253	S:S:I47	2.85	No	No	0	5	4
36	S:S:I48	S:S:L91	2.85	No	Yes	0	7	8
37	S:S:F293	S:S:I48	12.56	Yes	No	0	5	7
38	S:S:F49	S:S:L50	3.65	No	No	0	6	5
39	S:S:F49	S:S:L91	3.65	No	Yes	0	6	8
40	S:S:F49	S:S:P92	7.22	No	No	0	6	9
41	S:S:C296	S:S:T51	6.76	No	No	0	7	5
42	S:S:G52	S:S:V88	3.68	No	No	0	8	6
43	S:S:G55	S:S:V54	3.68	No	No	0	8	4
44	R:R:L216	S:S:V54	4.47	No	No	0	4	4
45	S:S:G55	S:S:P299	4.06	No	Yes	0	8	9
46	S:S:N56	S:S:S81	4.47	Yes	Yes	0	9	9
47	S:S:D84	S:S:N56	12.12	No	Yes	0	9	9
48	S:S:N56	S:S:V88	2.96	Yes	No	0	9	6
49	S:S:N56	S:S:P299	3.26	Yes	Yes	0	9	9
50	R:R:I223	S:S:L58	8.56	No	No	0	4	5
51	S:S:S81	S:S:V59	8.08	Yes	No	0	9	8
52	S:S:P299	S:S:V59	3.53	Yes	No	0	9	8
53	S:S:I60	S:S:V82	3.07	Yes	No	0	7	5
54	S:S:I60	S:S:L85	4.28	Yes	No	0	7	7
55	R:R:S224	S:S:L61	3	No	No	0	4	4
56	S:S:M63	S:S:V62	3.04	No	No	0	6	7
57	S:S:K68	S:S:V62	4.55	No	No	0	6	7
58	S:S:D74	S:S:M63	5.54	No	No	18	8	6
59	S:S:M63	S:S:Y302	8.38	No	No	18	6	9
60	S:S:G64	S:S:L78	3.42	No	No	0	2	5
61	R:R:S227	S:S:Q66	8.66	No	No	0	4	4
62	R:R:H228	S:S:Q66	12.36	No	No	0	5	4
63	S:S:K68	S:S:R70	3.71	No	No	0	6	6
64	R:R:K230	S:S:K68	10.06	No	No	0	5	6
65	S:S:K75	S:S:L69	5.64	No	No	0	6	6
66	S:S:S71	S:S:T73	3.2	No	No	0	7	7
67	S:S:D74	S:S:S71	5.89	No	No	0	8	7
68	S:S:K75	S:S:M72	2.88	No	No	0	6	6
69	S:S:M72	S:S:R148	3.72	No	No	0	6	6
70	S:S:A152	S:S:M72	3.22	No	No	0	3	6
71	S:S:R134	S:S:T73	3.88	Yes	No	0	9	7
72	S:S:D74	S:S:Y302	6.9	No	No	18	8	9
73	S:S:E153	S:S:K75	5.4	No	No	0	7	6
74	S:S:F129	S:S:Y76	4.13	No	Yes	0	5	7
75	S:S:I130	S:S:Y76	4.84	No	Yes	0	8	7
76	S:S:D133	S:S:Y76	9.2	No	Yes	0	8	7
77	S:S:A152	S:S:Y76	4	No	Yes	0	3	7
78	S:S:V156	S:S:Y76	3.79	No	Yes	0	5	7
79	S:S:N298	S:S:R77	3.62	No	No	0	9	8
80	S:S:R77	S:S:Y302	30.87	No	No	0	8	9
81	S:S:H79	S:S:Y157	4.36	No	No	0	9	7
82	S:S:H79	S:S:W161	3.17	No	Yes	0	9	9
83	S:S:I126	S:S:L80	7.14	No	No	0	7	9
84	S:S:N298	S:S:S81	5.96	No	Yes	0	9	9
85	S:S:C295	S:S:D84	7.78	No	No	0	9	9
86	S:S:F87	S:S:L91	3.65	Yes	Yes	0	7	8
87	S:S:F87	S:S:Y116	8.25	Yes	Yes	3	7	6
88	S:S:F87	S:S:N119	9.67	Yes	No	0	7	8
89	S:S:F292	S:S:F87	15	No	Yes	3	7	7
90	S:S:C295	S:S:V88	3.42	No	No	0	9	6
91	S:S:I89	S:S:T90	3.04	No	No	0	4	6
92	S:S:T90	S:S:V112	6.35	No	Yes	0	6	5
93	S:S:I115	S:S:T90	7.6	No	No	0	5	6
94	S:S:F104	S:S:F93	11.79	No	No	0	7	6
95	S:S:F93	S:S:L108	3.65	No	No	0	6	5
96	S:S:F93	S:S:V112	3.93	No	Yes	0	6	5
97	S:S:V112	S:S:W94	6.13	Yes	Yes	0	5	7
98	S:S:H113	S:S:W94	6.35	Yes	Yes	3	6	7
99	M:M:K22	S:S:W94	13.92	Yes	Yes	3	9	7
100	S:S:F104	S:S:V96	5.24	No	No	0	7	5
101	S:S:D97	S:S:W102	8.93	No	Yes	0	5	9
102	R:R:I261	S:S:V99	9.22	No	No	17	5	4
103	R:R:I270	S:S:A100	3.25	No	No	0	5	5
104	S:S:N101	S:S:R183	6.03	No	No	0	4	3
105	S:S:F104	S:S:W102	17.04	No	Yes	0	7	9
106	S:S:C109	S:S:W102	3.92	No	Yes	3	9	9
107	S:S:V112	S:S:W102	3.68	Yes	Yes	0	5	9
108	S:S:C186	S:S:W102	16.98	No	Yes	3	9	9
109	S:S:C109	S:S:H113	2.95	No	Yes	3	9	6
110	S:S:C109	S:S:C186	7.28	No	No	3	9	9
111	S:S:K110	S:S:N176	6.99	No	No	0	7	4
112	S:S:D171	S:S:H113	3.78	No	Yes	0	4	6
113	S:S:A175	S:S:H113	4.39	No	Yes	0	4	6
114	S:S:C186	S:S:H113	4.42	No	Yes	3	9	6
115	M:M:K22	S:S:H113	7.86	Yes	Yes	3	9	6
116	S:S:T168	S:S:V114	4.76	No	No	0	6	5
117	S:S:F172	S:S:V114	10.49	No	No	0	4	5
118	S:S:L120	S:S:Y116	3.52	Yes	Yes	3	7	6
119	S:S:F292	S:S:Y116	8.25	No	Yes	3	7	6
120	M:M:K22	S:S:Y116	4.78	Yes	Yes	3	9	6
121	S:S:T117	S:S:T168	3.14	No	No	0	5	6
122	S:S:D171	S:S:T117	13.01	No	No	0	4	5
123	M:M:P23	S:S:T117	5.25	Yes	No	0	9	5
124	S:S:H294	S:S:N119	3.83	Yes	No	0	9	8
125	S:S:H203	S:S:L120	6.43	Yes	Yes	3	4	7
126	S:S:L120	S:S:W252	5.69	Yes	Yes	3	7	9
127	M:M:P23	S:S:L120	3.28	Yes	Yes	3	9	7
128	S:S:L167	S:S:Y121	11.72	No	No	3	5	7
129	S:S:H203	S:S:Y121	5.44	Yes	No	3	4	7
130	S:S:V206	S:S:Y121	3.79	No	No	3	4	7
131	S:S:S122	S:S:V160	3.23	Yes	Yes	19	7	7
132	S:S:S122	S:S:W161	9.88	Yes	Yes	19	7	9
133	S:S:F248	S:S:S123	6.61	Yes	No	0	9	9
134	S:S:P211	S:S:V124	3.53	No	No	0	9	7
135	S:S:F248	S:S:V124	3.93	Yes	No	0	9	7
136	S:S:L125	S:S:V160	4.47	No	Yes	0	5	7
137	S:S:I126	S:S:I130	2.94	No	No	0	7	8
138	S:S:I126	S:S:V160	6.14	No	Yes	0	7	7
139	S:S:I245	S:S:L127	5.71	Yes	No	0	7	8
140	S:S:F248	S:S:L127	6.09	Yes	No	0	9	8
141	S:S:F129	S:S:L151	3.65	No	No	0	5	4
142	S:S:F129	S:S:G159	3.01	No	No	0	5	3
143	S:S:I215	S:S:S131	9.29	No	Yes	16	7	9
144	S:S:C218	S:S:S131	3.44	No	Yes	0	6	9
145	S:S:S131	S:S:Y219	8.9	Yes	Yes	16	9	8
146	S:S:I245	S:S:S131	3.1	Yes	Yes	16	7	9
147	S:S:D133	S:S:R148	8.34	No	No	0	8	6
148	S:S:A137	S:S:R134	4.15	No	Yes	0	8	9
149	S:S:V139	S:S:Y135	5.05	No	Yes	20	7	8
150	S:S:H140	S:S:Y135	3.27	Yes	Yes	20	6	8
151	S:S:I221	S:S:Y135	6.04	No	Yes	0	4	8
152	S:S:L136	S:S:S144	4.5	No	No	0	5	5
153	S:S:A137	S:S:R148	6.91	No	No	0	8	6
154	S:S:I138	S:S:I222	4.42	No	No	0	8	8
155	S:S:I138	S:S:K234	2.91	No	No	0	8	7
156	S:S:H140	S:S:V139	11.07	Yes	No	20	6	7
157	S:S:K225	S:S:V139	3.04	No	No	0	4	7
158	S:S:N143	S:S:T142	5.85	No	No	0	5	5
159	S:S:Q145	S:S:R146	8.18	No	No	0	5	5
160	S:S:E153	S:S:K149	10.8	No	No	0	7	6
161	S:S:K154	S:S:L150	4.23	No	No	0	3	4
162	S:S:L150	S:S:V155	4.47	No	No	0	4	2
163	S:S:A152	S:S:E153	4.53	No	No	0	3	7
164	S:S:I162	S:S:V158	4.61	No	No	0	4	4
165	S:S:V160	S:S:W161	3.68	Yes	Yes	19	7	9
166	S:S:I162	S:S:P163	3.39	No	No	0	4	4
167	S:S:L167	S:S:Q202	3.99	No	No	3	5	3
168	S:S:L167	S:S:V206	2.98	No	No	3	5	4
169	S:S:I169	S:S:P170	3.39	No	Yes	0	3	8
170	S:S:F174	S:S:P170	2.89	Yes	Yes	0	4	8
171	S:S:P170	S:S:R188	2.88	Yes	Yes	0	8	5
172	S:S:F199	S:S:P170	8.67	No	Yes	0	5	8
173	S:S:D171	S:S:R188	14.29	No	Yes	0	4	5
174	S:S:F174	S:S:I173	11.3	Yes	No	0	4	3
175	S:S:F174	S:S:Y190	6.19	Yes	Yes	10	4	4
176	S:S:F174	S:S:P191	2.89	Yes	No	10	4	5
177	S:S:F174	S:S:W195	5.01	Yes	Yes	10	4	5
178	S:S:I185	S:S:S178	3.1	No	Yes	0	3	1
179	S:S:F189	S:S:S178	3.96	No	Yes	0	3	1
180	S:S:E179	S:S:Y184	6.73	No	No	0	2	5
181	S:S:A180	S:S:R183	6.91	No	No	0	1	3
182	S:S:D181	S:S:R183	17.87	No	No	0	2	3
183	M:M:S25	S:S:D187	7.36	No	No	0	9	3
184	M:M:S27	S:S:D187	8.83	No	No	0	6	3
185	S:S:R188	S:S:Y190	17.49	Yes	Yes	0	5	4
186	M:M:P23	S:S:R188	2.88	Yes	Yes	0	9	5
187	M:M:Y28	S:S:F189	9.28	No	No	0	8	3
188	S:S:P191	S:S:Y190	4.17	No	Yes	10	5	4
189	S:S:W195	S:S:Y190	5.79	Yes	Yes	10	5	4
190	S:S:V196	S:S:Y190	7.57	No	Yes	0	4	4
191	S:S:F199	S:S:Y190	13.41	No	Yes	10	5	4
192	S:S:N192	S:S:P191	3.26	No	No	0	1	5
193	S:S:L194	S:S:N192	5.49	No	No	0	2	1
194	S:S:N192	S:S:W195	9.04	No	Yes	0	1	5
195	S:S:F199	S:S:W195	4.01	No	Yes	10	5	5
196	S:S:L266	S:S:V197	4.47	No	No	0	3	3
197	S:S:D262	S:S:Q200	6.53	No	No	0	5	5
198	S:S:Q200	S:S:S263	5.78	No	No	0	5	5
199	M:M:V24	S:S:Q200	4.3	Yes	No	0	7	5
200	S:S:F201	S:S:S263	7.93	No	No	0	4	5
201	S:S:F201	S:S:F264	4.29	No	No	0	4	4
202	S:S:Q202	S:S:V206	4.3	No	No	3	3	4
203	S:S:H203	S:S:Y255	6.53	Yes	Yes	3	4	7
204	S:S:H203	S:S:Y256	7.62	Yes	Yes	3	4	8
205	M:M:P23	S:S:H203	16.78	Yes	Yes	3	9	4
206	S:S:I204	S:S:I259	5.89	No	Yes	0	5	5
207	S:S:I209	S:S:M205	5.83	No	No	0	4	4
208	S:S:G207	S:S:Y256	2.9	No	Yes	0	5	8
209	S:S:L208	S:S:Y256	11.72	No	Yes	0	8	8
210	S:S:I215	S:S:I245	2.94	No	Yes	16	7	7
211	P:P:V54	S:S:L216	4.47	No	No	0	4	4
212	S:S:I222	S:S:Y219	4.84	No	Yes	0	8	8
213	S:S:V242	S:S:Y219	7.57	No	Yes	0	4	8
214	S:S:I245	S:S:Y219	3.63	Yes	Yes	16	7	8
215	S:S:I222	S:S:L238	2.85	No	No	0	8	5
216	P:P:L58	S:S:I223	8.56	No	No	0	5	4
217	S:S:K225	S:S:S224	3.06	No	No	0	4	4
218	P:P:L61	S:S:S224	3	No	No	0	4	4
219	S:S:L226	S:S:S229	3	No	No	0	8	5
220	P:P:Q66	S:S:S227	8.66	No	No	0	4	4
221	P:P:Q66	S:S:H228	8.65	No	No	0	4	5
222	S:S:H232	S:S:K234	10.48	No	No	0	4	7
223	S:S:K236	S:S:Q233	10.85	No	No	0	8	5
224	S:S:K236	S:S:R235	3.71	No	No	0	8	5
225	S:S:I243	S:S:K239	4.36	No	No	0	5	6
226	S:S:T240	S:S:T241	3.14	No	No	0	7	7
227	S:S:I243	S:S:L301	4.28	No	No	0	5	7
228	S:S:A247	S:S:L297	4.73	No	No	0	6	6
229	S:S:F248	S:S:F249	3.22	Yes	No	0	9	4
230	S:S:F248	S:S:W252	13.03	Yes	Yes	3	9	9
231	S:S:F248	S:S:H294	7.92	Yes	Yes	3	9	9
232	S:S:W252	S:S:Y255	5.79	Yes	Yes	3	9	7
233	S:S:A291	S:S:W252	7.78	No	Yes	0	8	9
234	S:S:H294	S:S:W252	15.87	Yes	Yes	3	9	9
235	P:P:I47	S:S:L253	2.85	No	No	0	4	5
236	S:S:P254	S:S:T287	3.5	No	No	0	9	6
237	P:P:T43	S:S:P254	3.5	No	No	0	4	9
238	S:S:Y255	S:S:Y256	4.96	Yes	Yes	3	7	8
239	S:S:I259	S:S:Y255	9.67	Yes	Yes	3	5	7
240	S:S:E288	S:S:Y255	5.61	No	Yes	0	5	7
241	M:M:V24	S:S:Y255	6.31	Yes	Yes	3	7	7
242	S:S:I259	S:S:Y256	3.63	Yes	Yes	3	5	8
243	P:P:T43	S:S:I257	4.56	No	No	0	4	6
244	P:P:S46	S:S:I257	6.19	No	No	0	5	6
245	S:S:I259	S:S:I284	4.42	Yes	No	0	5	4
246	M:M:V24	S:S:I259	3.07	Yes	Yes	3	7	5
247	S:S:I261	S:S:V280	3.07	Yes	Yes	11	5	5
248	P:P:I39	S:S:I261	2.94	No	Yes	11	5	5
249	P:P:P42	S:S:I261	3.39	No	Yes	11	5	5
250	P:P:V99	S:S:I261	9.22	No	Yes	11	4	5
251	S:S:D262	S:S:I284	4.2	No	No	0	5	4
252	S:S:I265	S:S:I270	4.42	No	No	0	3	5
253	S:S:F276	S:S:I265	3.77	Yes	No	0	1	3
254	S:S:I269	S:S:L267	2.85	No	No	0	1	1
255	S:S:E268	S:S:K271	4.05	No	Yes	9	2	3
256	M:M:R33	S:S:E268	10.47	No	No	9	9	2
257	S:S:I269	S:S:I270	5.89	No	No	0	1	5
258	S:S:I270	S:S:Q272	5.49	No	No	0	5	2
259	M:M:R33	S:S:K271	3.71	No	Yes	9	9	3
260	M:M:F34	S:S:K271	3.72	No	Yes	9	6	3
261	P:P:K38	S:S:Q272	4.07	No	No	0	4	2
262	S:S:F276	S:S:G273	3.01	Yes	No	0	1	5
263	S:S:C274	S:S:E275	3.04	No	No	0	5	3
264	S:S:F276	S:S:V280	6.55	Yes	Yes	0	1	5
265	P:P:N35	S:S:F276	4.83	Yes	Yes	0	3	1
266	P:P:K38	S:S:F276	3.72	No	Yes	0	4	1
267	M:M:R29	S:S:E277	6.98	Yes	No	0	9	2
268	P:P:N35	S:S:T279	5.85	Yes	No	0	3	2
269	S:S:I284	S:S:V280	3.07	No	Yes	0	4	5
270	P:P:I39	S:S:V280	3.07	No	Yes	11	5	5
271	M:M:L26	S:S:H281	7.71	No	No	0	9	4
272	S:S:T287	S:S:W283	9.7	No	Yes	0	6	6
273	P:P:F36	S:S:W283	3.01	No	Yes	0	4	6
274	P:P:I39	S:S:W283	14.09	No	Yes	0	5	6
275	P:P:T43	S:S:W283	7.28	No	Yes	0	4	6
276	M:M:L26	S:S:S285	3	No	No	0	9	5
277	M:M:K22	S:S:E288	8.1	Yes	No	0	9	5
278	S:S:C296	S:S:F293	5.59	No	Yes	0	7	5
279	S:S:C295	S:S:H294	7.37	No	Yes	0	9	9
280	S:S:N298	S:S:P299	4.89	No	Yes	0	9	9
281	R:R:F29	R:R:P27	8.67	No	No	0	4	5
282	R:R:C274	R:R:C28	7.28	No	No	0	5	9
283	L:L:P31	R:R:F29	4.33	No	No	0	7	4
284	R:R:H281	R:R:R30	3.39	Yes	No	0	4	5
285	R:R:E31	R:R:N33	5.26	No	No	0	5	6
286	R:R:A34	R:R:E32	3.02	No	No	0	1	4
287	R:R:E32	R:R:H281	3.69	No	Yes	0	4	4
288	R:R:N33	R:R:N35	8.17	No	Yes	0	6	3
289	R:R:A34	R:R:N37	4.69	No	No	0	1	3
290	R:R:A34	R:R:K282	3.21	No	No	0	1	2
291	C:C:F276	R:R:N35	4.83	Yes	Yes	0	1	3
292	C:C:T279	R:R:N35	7.31	No	Yes	0	2	3
293	R:R:F36	R:R:F40	9.65	No	No	0	4	5
294	C:C:W283	R:R:F36	3.01	Yes	No	0	6	4
295	R:R:N37	R:R:S285	2.98	No	No	21	3	5
296	R:R:I286	R:R:N37	4.25	No	No	21	6	3
297	C:C:F276	R:R:K38	3.72	Yes	No	0	1	4
298	C:C:I261	R:R:I39	4.42	No	No	0	5	5
299	C:C:V280	R:R:I39	3.07	No	No	0	5	5
300	C:C:W283	R:R:I39	12.92	Yes	No	0	6	5
301	R:R:F40	R:R:I44	11.3	No	No	0	5	5
302	R:R:L41	R:R:Y45	3.52	No	Yes	1	6	7
303	R:R:A289	R:R:L41	4.73	No	No	1	4	6
304	R:R:A98	R:R:P42	3.74	No	No	0	5	5
305	R:R:P42	R:R:V99	3.53	No	No	22	5	4
306	C:C:I261	R:R:P42	3.39	No	No	22	5	5
307	C:C:P254	R:R:T43	3.5	No	No	0	9	4
308	C:C:I257	R:R:T43	4.56	No	No	0	6	4
309	C:C:W283	R:R:T43	7.28	Yes	No	0	6	4
310	R:R:I44	R:R:I48	2.94	No	Yes	0	5	7
311	R:R:L91	R:R:Y45	3.52	Yes	Yes	0	8	7
312	R:R:A289	R:R:Y45	4	No	Yes	1	4	7
313	R:R:F292	R:R:Y45	7.22	No	Yes	1	7	7
314	C:C:I257	R:R:S46	6.19	No	No	0	6	5
315	C:C:L253	R:R:I47	2.85	No	No	0	5	4
316	R:R:I48	R:R:L91	2.85	Yes	Yes	0	7	8
317	R:R:F293	R:R:I48	5.02	No	Yes	0	5	7
318	R:R:C295	R:R:I48	3.27	No	Yes	0	9	7
319	R:R:F49	R:R:L91	3.65	No	Yes	0	6	8
320	R:R:F49	R:R:P92	13	No	No	0	6	9
321	R:R:C296	R:R:T51	5.07	No	No	0	7	5
322	R:R:I53	R:R:I89	2.94	No	No	0	5	4
323	R:R:G55	R:R:V54	3.68	No	No	0	8	4
324	C:C:L216	R:R:V54	4.47	No	No	0	4	4
325	R:R:G55	R:R:P299	4.06	No	No	0	8	9
326	R:R:N56	R:R:S81	4.47	No	No	0	9	9
327	R:R:D84	R:R:N56	12.12	No	No	0	9	9
328	C:C:I223	R:R:L58	8.56	No	No	0	4	5
329	R:R:S81	R:R:V59	8.08	No	No	0	9	8
330	C:C:S224	R:R:L61	3	No	No	0	4	4
331	R:R:M63	R:R:V62	3.04	Yes	No	0	6	7
332	R:R:D74	R:R:M63	6.93	No	Yes	23	8	6
333	R:R:M63	R:R:Y302	8.38	Yes	No	23	6	9
334	R:R:G64	R:R:L78	5.13	No	No	0	2	5
335	R:R:K68	R:R:Q66	4.07	No	No	24	6	4
336	C:C:S227	R:R:Q66	11.55	No	No	24	4	4
337	C:C:H228	R:R:Q66	4.95	No	No	0	5	4
338	C:C:S227	R:R:K68	3.06	No	No	24	4	6
339	R:R:K75	R:R:L69	4.23	No	No	0	6	6
340	R:R:D74	R:R:S71	2.94	No	No	0	8	7
341	R:R:M72	R:R:R148	3.72	No	Yes	0	6	6
342	R:R:A152	R:R:M72	3.22	No	No	0	3	6
343	R:R:R134	R:R:T73	3.88	Yes	No	0	9	7
344	R:R:D74	R:R:Y302	6.9	No	No	23	8	9
345	R:R:E153	R:R:K75	9.45	No	No	0	7	6
346	R:R:I126	R:R:Y76	3.63	No	Yes	0	7	7
347	R:R:F129	R:R:Y76	5.16	Yes	Yes	0	5	7
348	R:R:I130	R:R:Y76	4.84	No	Yes	0	8	7
349	R:R:D133	R:R:Y76	6.9	No	Yes	0	8	7
350	R:R:A152	R:R:Y76	4	No	Yes	0	3	7
351	R:R:V156	R:R:Y76	3.79	No	Yes	0	5	7
352	R:R:N298	R:R:R77	10.85	Yes	No	0	9	8
353	R:R:R77	R:R:Y302	21.61	No	No	0	8	9
354	R:R:H79	R:R:I126	5.3	Yes	No	0	9	7
355	R:R:H79	R:R:V156	5.54	Yes	No	0	9	5
356	R:R:H79	R:R:Y157	6.53	Yes	No	12	9	7
357	R:R:H79	R:R:W161	3.17	Yes	Yes	12	9	9
358	R:R:L80	R:R:N298	9.61	No	Yes	0	9	9
359	R:R:N298	R:R:S81	5.96	Yes	No	0	9	9
360	R:R:A83	R:R:S122	3.42	No	Yes	0	8	7
361	R:R:C295	R:R:D84	7.78	No	No	0	9	9
362	R:R:F87	R:R:L91	3.65	Yes	Yes	0	7	8
363	R:R:F87	R:R:Y116	6.19	Yes	Yes	1	7	6
364	R:R:F87	R:R:N119	13.29	Yes	No	0	7	8
365	R:R:F292	R:R:F87	10.72	No	Yes	1	7	7
366	R:R:C295	R:R:V88	3.42	No	No	0	9	6
367	R:R:I89	R:R:T90	3.04	No	No	0	4	6
368	R:R:T90	R:R:V112	6.35	No	Yes	0	6	5
369	R:R:I115	R:R:T90	7.6	No	No	0	5	6
370	R:R:F93	R:R:W102	4.01	No	Yes	6	6	9
371	R:R:F104	R:R:F93	10.72	Yes	No	6	7	6
372	R:R:F93	R:R:V112	3.93	No	Yes	6	6	5
373	R:R:D97	R:R:W94	3.35	No	Yes	0	5	7
374	R:R:V112	R:R:W94	6.13	Yes	Yes	0	5	7
375	R:R:H113	R:R:W94	7.41	Yes	Yes	0	6	7
376	L:L:K22	R:R:W94	12.76	No	Yes	0	9	7
377	R:R:F104	R:R:V96	6.55	Yes	No	0	7	5
378	R:R:D97	R:R:N101	4.04	No	No	0	5	4
379	R:R:D97	R:R:W102	5.58	No	Yes	0	5	9
380	C:C:I261	R:R:V99	4.61	No	No	22	5	4
381	R:R:N101	R:R:R183	9.64	No	No	0	4	3
382	R:R:F104	R:R:W102	16.04	Yes	Yes	6	7	9
383	R:R:C109	R:R:W102	3.92	No	Yes	6	9	9
384	R:R:V112	R:R:W102	4.9	Yes	Yes	6	5	9
385	R:R:C186	R:R:W102	18.28	No	Yes	6	9	9
386	R:R:R183	R:R:Y103	7.2	No	No	0	3	3
387	R:R:F104	R:R:L108	4.87	Yes	No	0	7	5
388	R:R:K110	R:R:N106	5.6	No	No	26	7	3
389	R:R:N106	R:R:N176	12.26	No	No	26	3	4
390	R:R:N106	R:R:V177	5.91	No	No	0	3	4
391	R:R:C109	R:R:H113	2.95	No	Yes	6	9	6
392	R:R:C109	R:R:C186	7.28	No	No	6	9	9
393	R:R:K110	R:R:N176	8.39	No	No	26	7	4
394	R:R:D171	R:R:H113	3.78	No	Yes	0	4	6
395	R:R:A175	R:R:H113	4.39	No	Yes	0	4	6
396	R:R:C186	R:R:H113	2.95	No	Yes	6	9	6
397	R:R:F172	R:R:V114	10.49	No	No	0	4	5
398	R:R:E288	R:R:Y116	3.37	No	Yes	1	5	6
399	R:R:F292	R:R:Y116	6.19	No	Yes	1	7	6
400	L:L:K22	R:R:Y116	7.17	No	Yes	1	9	6
401	R:R:T117	R:R:Y121	3.75	Yes	Yes	0	5	7
402	R:R:T117	R:R:T168	3.14	Yes	No	0	5	6
403	R:R:D171	R:R:T117	10.12	No	Yes	0	4	5
404	L:L:P23	R:R:T117	5.25	No	Yes	0	9	5
405	R:R:H294	R:R:N119	5.1	No	No	0	9	8
406	R:R:H203	R:R:L120	5.14	Yes	No	1	4	7
407	R:R:L120	R:R:W252	4.56	No	Yes	1	7	9
408	L:L:P23	R:R:L120	3.28	No	No	1	9	7
409	R:R:L167	R:R:Y121	8.21	No	Yes	1	5	7
410	R:R:H203	R:R:Y121	5.44	Yes	Yes	1	4	7
411	R:R:V206	R:R:Y121	6.31	No	Yes	1	4	7
412	R:R:S122	R:R:V160	3.23	Yes	Yes	12	7	7
413	R:R:S122	R:R:W161	11.12	Yes	Yes	12	7	9
414	R:R:F248	R:R:S123	5.28	Yes	No	0	9	9
415	R:R:P211	R:R:V124	3.53	No	No	0	9	7
416	R:R:L125	R:R:V160	4.47	No	Yes	0	5	7
417	R:R:L125	R:R:P163	3.28	No	No	0	5	4
418	R:R:I126	R:R:V160	6.14	No	Yes	0	7	7
419	R:R:I245	R:R:L127	7.14	No	No	0	7	8
420	R:R:F248	R:R:L127	6.09	Yes	No	0	9	8
421	R:R:F129	R:R:G159	3.01	Yes	No	0	5	3
422	R:R:F129	R:R:V160	3.93	Yes	Yes	0	5	7
423	R:R:I130	R:R:T241	3.04	No	Yes	0	8	7
424	R:R:I215	R:R:S131	9.29	No	No	0	7	9
425	R:R:C218	R:R:S131	3.44	No	No	0	6	9
426	R:R:S131	R:R:Y219	5.09	No	Yes	0	9	8
427	R:R:D133	R:R:R148	14.29	No	Yes	0	8	6
428	R:R:A137	R:R:R134	4.15	No	Yes	0	8	9
429	R:R:R134	R:R:T241	5.17	Yes	Yes	0	9	7
430	R:R:L136	R:R:Y135	3.52	Yes	Yes	0	5	8
431	R:R:V139	R:R:Y135	6.31	No	Yes	0	7	8
432	R:R:C218	R:R:Y135	4.03	No	Yes	0	6	8
433	R:R:I221	R:R:Y135	6.04	No	Yes	0	4	8
434	R:R:L136	R:R:S144	3	Yes	No	25	5	5
435	R:R:L136	R:R:R148	3.64	Yes	Yes	25	5	6
436	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
437	R:R:I138	R:R:I222	5.89	No	No	0	8	8
438	R:R:H140	R:R:V139	4.15	No	No	0	6	7
439	R:R:K225	R:R:V139	6.07	No	No	0	4	7
440	R:R:H140	R:R:N143	5.1	No	No	0	6	5
441	R:R:N143	R:R:T142	5.85	No	No	0	5	5
442	R:R:R148	R:R:S144	3.95	Yes	No	25	6	5
443	R:R:E153	R:R:K149	5.4	No	No	0	7	6
444	R:R:L151	R:R:V155	4.47	No	No	0	4	2
445	R:R:W161	R:R:Y157	2.89	Yes	No	12	9	7
446	R:R:I162	R:R:V158	3.07	No	No	0	4	4
447	R:R:G159	R:R:P163	4.06	No	No	0	3	4
448	R:R:V160	R:R:W161	3.68	Yes	Yes	12	7	9
449	R:R:I162	R:R:P163	3.39	No	No	0	4	4
450	R:R:L167	R:R:Q202	3.99	No	No	1	5	3
451	R:R:L167	R:R:V206	4.47	No	No	1	5	4
452	R:R:I169	R:R:P170	3.39	No	Yes	0	3	8
453	R:R:F174	R:R:P170	2.89	Yes	Yes	0	4	8
454	R:R:P170	R:R:R188	2.88	Yes	Yes	0	8	5
455	R:R:F199	R:R:P170	8.67	Yes	Yes	0	5	8
456	R:R:D171	R:R:R188	9.53	No	Yes	0	4	5
457	R:R:F174	R:R:I173	11.3	Yes	No	0	4	3
458	R:R:F174	R:R:Y190	8.25	Yes	Yes	7	4	4
459	R:R:F174	R:R:W195	5.01	Yes	Yes	7	4	5
460	R:R:V177	R:R:Y184	5.05	No	No	0	4	5
461	R:R:F189	R:R:S178	6.61	No	No	0	3	1
462	L:L:N54	R:R:S178	2.98	No	No	0	8	1
463	R:R:E179	R:R:Y184	15.71	No	No	0	2	5
464	R:R:A180	R:R:I185	3.25	No	No	0	1	3
465	L:L:P53	R:R:D181	4.83	No	No	0	7	2
466	R:R:R183	R:R:Y184	5.14	No	No	0	3	5
467	L:L:S27	R:R:I185	3.1	No	No	0	6	3
468	R:R:D187	R:R:R188	3.57	No	Yes	7	3	5
469	L:L:S25	R:R:D187	4.42	No	No	7	9	3
470	L:L:S27	R:R:D187	5.89	No	No	0	6	3
471	R:R:R188	R:R:Y190	14.4	Yes	Yes	7	5	4
472	L:L:S25	R:R:R188	5.27	No	Yes	7	9	5
473	L:L:Y28	R:R:F189	8.25	No	No	0	8	3
474	R:R:P191	R:R:Y190	4.17	No	Yes	0	5	4
475	R:R:W195	R:R:Y190	7.72	Yes	Yes	7	5	4
476	R:R:V196	R:R:Y190	7.57	No	Yes	0	4	4
477	R:R:F199	R:R:Y190	14.44	Yes	Yes	7	5	4
478	R:R:N192	R:R:P191	4.89	No	No	0	1	5
479	R:R:N192	R:R:W195	5.65	No	Yes	0	1	5
480	R:R:L194	R:R:W195	4.56	No	Yes	0	2	5
481	R:R:F199	R:R:W195	3.01	Yes	Yes	7	5	5
482	R:R:L267	R:R:V197	4.47	No	No	0	1	3
483	R:R:D262	R:R:Q200	6.53	Yes	No	0	5	5
484	R:R:Q200	R:R:S263	8.66	No	No	0	5	5
485	L:L:V24	R:R:Q200	4.3	No	No	0	7	5
486	R:R:F201	R:R:S263	5.28	No	No	0	4	5
487	R:R:F201	R:R:F264	4.29	No	No	0	4	4
488	R:R:Q202	R:R:V206	4.3	No	No	1	3	4
489	R:R:H203	R:R:Y255	6.53	Yes	Yes	1	4	7
490	R:R:H203	R:R:Y256	8.71	Yes	Yes	1	4	8
491	L:L:P23	R:R:H203	13.73	No	Yes	1	9	4
492	R:R:I204	R:R:I259	5.89	No	Yes	0	5	5
493	R:R:I209	R:R:M205	4.37	No	No	0	4	4
494	R:R:G207	R:R:Y256	2.9	No	Yes	0	5	8
495	R:R:I209	R:R:L208	2.85	No	No	0	4	8
496	R:R:L208	R:R:Y256	12.89	No	Yes	0	8	8
497	R:R:I215	R:R:I245	2.94	No	No	0	7	7
498	R:R:T241	R:R:Y219	6.24	Yes	Yes	0	7	8
499	R:R:V242	R:R:Y219	5.05	No	Yes	0	4	8
500	R:R:I245	R:R:Y219	3.63	No	Yes	0	7	8
501	R:R:I222	R:R:L238	5.71	No	No	0	8	5
502	R:R:K225	R:R:S224	3.06	No	No	0	4	4
503	R:R:H232	R:R:S229	8.37	No	No	0	4	5
504	R:R:H232	R:R:R235	7.9	No	No	0	4	5
505	R:R:K236	R:R:Q233	8.14	No	No	0	8	5
506	R:R:K234	R:R:R235	4.95	No	No	0	7	5
507	R:R:I243	R:R:K239	2.91	No	No	0	5	6
508	R:R:T240	R:R:T241	3.14	No	Yes	0	7	7
509	R:R:L246	R:R:V242	2.98	No	No	0	5	4
510	R:R:I243	R:R:L301	4.28	No	No	0	5	7
511	R:R:A247	R:R:L297	4.73	No	No	0	6	6
512	R:R:F248	R:R:F249	3.22	Yes	No	0	9	4
513	R:R:F248	R:R:W252	12.03	Yes	Yes	1	9	9
514	R:R:F248	R:R:H294	7.92	Yes	No	1	9	9
515	R:R:W252	R:R:Y255	5.79	Yes	Yes	1	9	7
516	R:R:A291	R:R:W252	7.78	No	Yes	0	8	9
517	R:R:H294	R:R:W252	11.64	No	Yes	1	9	9
518	R:R:P254	R:R:T287	3.5	No	No	0	9	6
519	R:R:Y255	R:R:Y256	4.96	Yes	Yes	1	7	8
520	R:R:I259	R:R:Y255	8.46	Yes	Yes	1	5	7
521	R:R:E288	R:R:Y255	5.61	No	Yes	1	5	7
522	L:L:V24	R:R:Y255	5.05	No	Yes	1	7	7
523	R:R:I259	R:R:Y256	3.63	Yes	Yes	1	5	8
524	R:R:I259	R:R:I284	4.42	Yes	No	1	5	4
525	L:L:V24	R:R:I259	4.61	No	Yes	1	7	5
526	R:R:D262	R:R:V280	2.92	Yes	No	1	5	5
527	R:R:D262	R:R:I284	4.2	Yes	No	1	5	4
528	R:R:F264	R:R:I269	3.77	No	No	0	4	1
529	R:R:I265	R:R:I270	5.89	No	No	0	3	5
530	R:R:I269	R:R:I270	2.94	No	No	0	1	5
531	R:R:F276	R:R:Q272	5.86	Yes	No	0	1	2
532	R:R:E275	R:R:G273	4.91	No	No	0	3	5
533	R:R:F276	R:R:V280	5.24	Yes	No	0	1	5
534	L:L:L26	R:R:E277	3.98	Yes	No	1	9	2
535	L:L:R29	R:R:E277	9.3	Yes	No	1	9	2
536	R:R:I284	R:R:V280	3.07	No	No	1	4	5
537	L:L:L26	R:R:H281	7.71	Yes	Yes	0	9	4
538	R:R:T287	R:R:W283	10.92	No	Yes	0	6	6
539	R:R:I286	R:R:S285	4.64	No	No	21	6	5
540	L:L:K22	R:R:E288	8.1	No	No	1	9	5
541	R:R:C296	R:R:F293	5.59	No	No	0	7	5
542	R:R:N298	R:R:P299	3.26	Yes	No	0	9	9
543	M:M:S25	M:M:Y28	5.09	No	No	0	9	8
544	M:M:R29	M:M:R33	4.26	Yes	No	0	9	9
545	M:M:C30	M:M:C32	7.28	No	No	0	9	9
546	M:M:C30	M:M:C55	5.46	No	No	0	9	9
547	q:q:K22	q:q:V24	7.59	No	No	27	9	7
548	q:q:K22	q:q:L26	4.23	No	No	27	9	9
549	q:q:L26	q:q:V24	4.47	No	No	27	9	7
550	q:q:C55	q:q:Y28	6.72	No	No	0	9	8
551	q:q:C30	q:q:C32	7.28	No	No	28	9	9
552	q:q:C55	q:q:T52	3.38	No	No	0	9	8
553	C:C:K25	C:C:K271	5.75	Yes	No	0	4	3
554	C:C:K25	Q:Q:F34	3.72	Yes	No	0	4	6
555	C:C:K25	Q:Q:V70	3.04	Yes	No	0	4	9
556	C:C:E26	C:C:P27	7.86	No	Yes	0	2	5
557	C:C:E26	C:C:F29	5.83	No	No	0	2	4
558	C:C:P27	Q:Q:C71	3.77	Yes	No	0	5	9
559	C:C:C28	Q:Q:P31	7.53	No	No	0	9	7
560	C:C:R30	Q:Q:R29	22.39	No	No	0	5	9
561	C:C:E31	C:C:N33	13.15	No	No	0	5	6
562	C:C:E31	C:C:N278	6.57	No	No	0	5	3
563	C:C:E31	C:C:K282	8.1	No	No	0	5	2
564	C:C:A34	C:C:N37	3.13	No	Yes	0	1	3
565	C:C:N35	P:P:E275	5.26	No	No	0	3	3
566	C:C:N35	P:P:T279	8.77	No	No	0	3	2
567	C:C:F36	C:C:F40	8.57	No	No	0	4	5
568	C:C:F36	P:P:W283	3.01	No	Yes	0	4	6
569	C:C:L41	C:C:N37	5.49	No	Yes	0	6	3
570	C:C:N37	C:C:S285	5.96	Yes	No	0	3	5
571	C:C:I286	C:C:N37	4.25	No	Yes	0	6	3
572	C:C:K38	P:P:F276	3.72	No	Yes	0	4	1
573	C:C:I39	P:P:I261	2.94	No	Yes	0	5	5
574	C:C:I39	P:P:W283	14.09	No	Yes	0	5	6
575	C:C:F40	C:C:I44	10.05	No	No	0	5	5
576	C:C:L41	C:C:Y45	5.86	No	Yes	0	6	7
577	C:C:A289	C:C:L41	3.15	No	No	0	4	6
578	C:C:A98	C:C:P42	3.74	No	No	0	5	5
579	C:C:P42	C:C:V99	3.53	No	No	29	5	4
580	C:C:P42	P:P:I261	3.39	No	Yes	29	5	5
581	C:C:T43	P:P:P254	3.5	No	No	0	4	9
582	C:C:T43	P:P:I257	4.56	No	No	0	4	6
583	C:C:T43	P:P:W283	7.28	No	Yes	0	4	6
584	C:C:I44	C:C:I48	2.94	No	No	0	5	7
585	C:C:L91	C:C:Y45	3.52	Yes	Yes	0	8	7
586	C:C:W94	C:C:Y45	2.89	Yes	Yes	0	7	7
587	C:C:A95	C:C:Y45	4	No	Yes	0	7	7
588	C:C:F292	C:C:Y45	7.22	Yes	Yes	0	7	7
589	C:C:S46	P:P:I257	6.19	No	No	0	5	6
590	C:C:I47	P:P:L253	2.85	No	No	0	4	5
591	C:C:I48	C:C:L91	2.85	No	Yes	0	7	8
592	C:C:F293	C:C:I48	12.56	Yes	No	0	5	7
593	C:C:F49	C:C:L50	3.65	No	No	0	6	5
594	C:C:F49	C:C:L91	3.65	No	Yes	0	6	8
595	C:C:F49	C:C:P92	7.22	No	No	0	6	9
596	C:C:C296	C:C:T51	6.76	No	No	0	7	5
597	C:C:G52	C:C:V88	5.52	No	No	0	8	6
598	C:C:G55	C:C:V54	3.68	No	No	0	8	4
599	C:C:V54	P:P:L216	4.47	No	No	0	4	4
600	C:C:G55	C:C:P299	4.06	No	No	0	8	9
601	C:C:N56	C:C:S81	5.96	No	Yes	0	9	9
602	C:C:D84	C:C:N56	9.42	No	No	0	9	9
603	C:C:L58	P:P:I223	7.14	No	No	0	5	4
604	C:C:S81	C:C:V59	8.08	Yes	No	0	9	8
605	C:C:P299	C:C:V59	3.53	No	No	0	9	8
606	C:C:I60	C:C:L85	2.85	No	No	0	7	7
607	C:C:L61	P:P:S224	3	No	No	0	4	4
608	C:C:M63	C:C:V62	3.04	No	No	0	6	7
609	C:C:K68	C:C:V62	4.55	No	No	0	6	7
610	C:C:D74	C:C:M63	6.93	No	No	31	8	6
611	C:C:M63	C:C:Y302	8.38	No	No	31	6	9
612	C:C:G64	C:C:L78	3.42	No	No	0	2	5
613	C:C:Q66	P:P:S227	8.66	No	No	0	4	4
614	C:C:Q66	P:P:H228	8.65	No	No	0	4	5
615	C:C:K68	C:C:R70	4.95	No	No	0	6	6
616	C:C:K75	C:C:L69	5.64	No	No	0	6	6
617	C:C:S71	C:C:T73	3.2	No	No	0	7	7
618	C:C:D74	C:C:S71	5.89	No	No	0	8	7
619	C:C:K75	C:C:M72	2.88	No	No	0	6	6
620	C:C:D133	C:C:M72	5.54	No	No	13	8	6
621	C:C:M72	C:C:R148	6.2	No	Yes	13	6	6
622	C:C:R134	C:C:T73	3.88	Yes	No	0	9	7
623	C:C:D74	C:C:Y302	6.9	No	No	31	8	9
624	C:C:E153	C:C:K75	9.45	No	No	0	7	6
625	C:C:F129	C:C:Y76	4.13	No	Yes	0	5	7
626	C:C:I130	C:C:Y76	4.84	No	Yes	0	8	7
627	C:C:D133	C:C:Y76	9.2	No	Yes	0	8	7
628	C:C:A152	C:C:Y76	4	No	Yes	0	3	7
629	C:C:N298	C:C:R77	3.62	Yes	No	0	9	8
630	C:C:R77	C:C:Y302	30.87	No	No	0	8	9
631	C:C:H79	C:C:Y157	4.36	No	No	0	9	7
632	C:C:H79	C:C:W161	5.29	No	Yes	0	9	9
633	C:C:D84	C:C:L80	4.07	No	No	0	9	9
634	C:C:I126	C:C:L80	4.28	No	No	0	7	9
635	C:C:L80	C:C:N298	8.24	No	Yes	0	9	9
636	C:C:N298	C:C:S81	4.47	Yes	Yes	0	9	9
637	C:C:C295	C:C:D84	9.34	No	No	0	9	9
638	C:C:F87	C:C:L91	3.65	Yes	Yes	0	7	8
639	C:C:F87	C:C:Y116	8.25	Yes	No	30	7	6
640	C:C:F87	C:C:N119	9.67	Yes	No	0	7	8
641	C:C:F292	C:C:F87	15	Yes	Yes	30	7	7
642	C:C:C295	C:C:V88	3.42	No	No	0	9	6
643	C:C:I89	C:C:T90	3.04	No	No	0	4	6
644	C:C:T90	C:C:V112	9.52	No	Yes	0	6	5
645	C:C:I115	C:C:T90	7.6	No	No	0	5	6
646	C:C:F93	C:C:W102	3.01	Yes	Yes	2	6	9
647	C:C:F104	C:C:F93	11.79	No	Yes	2	7	6
648	C:C:F93	C:C:L108	3.65	Yes	No	0	6	5
649	C:C:F93	C:C:V112	3.93	Yes	Yes	2	6	5
650	C:C:V112	C:C:W94	6.13	Yes	Yes	0	5	7
651	C:C:H113	C:C:W94	5.29	Yes	Yes	0	6	7
652	C:C:W94	Q:Q:K22	12.76	Yes	Yes	0	7	9
653	C:C:F104	C:C:V96	5.24	No	No	0	7	5
654	C:C:D97	C:C:W102	7.82	No	Yes	0	5	9
655	C:C:V99	P:P:I261	7.68	No	Yes	29	4	5
656	C:C:N101	C:C:R183	19.28	No	No	0	4	3
657	C:C:F104	C:C:W102	17.04	No	Yes	2	7	9
658	C:C:C109	C:C:W102	3.92	No	Yes	2	9	9
659	C:C:V112	C:C:W102	4.9	Yes	Yes	2	5	9
660	C:C:C186	C:C:W102	13.06	No	Yes	2	9	9
661	C:C:C109	C:C:H113	2.95	No	Yes	2	9	6
662	C:C:C109	C:C:C186	7.28	No	No	2	9	9
663	C:C:K110	C:C:N176	6.99	No	No	0	7	4
664	C:C:D171	C:C:H113	5.04	Yes	Yes	2	4	6
665	C:C:A175	C:C:H113	4.39	No	Yes	0	4	6
666	C:C:C186	C:C:H113	4.42	No	Yes	2	9	6
667	C:C:T168	C:C:V114	4.76	Yes	No	0	6	5
668	C:C:F172	C:C:V114	7.87	No	No	0	4	5
669	C:C:F292	C:C:Y116	8.25	Yes	No	30	7	6
670	C:C:Y116	Q:Q:K22	9.55	No	Yes	0	6	9
671	C:C:T117	C:C:T168	3.14	No	Yes	2	5	6
672	C:C:D171	C:C:T117	11.56	Yes	No	2	4	5
673	C:C:T117	Q:Q:P23	5.25	No	Yes	2	5	9
674	C:C:T168	C:C:V118	3.17	Yes	No	0	6	5
675	C:C:H294	C:C:N119	3.83	Yes	No	0	9	8
676	C:C:H203	C:C:L120	6.43	Yes	No	2	4	7
677	C:C:L120	C:C:W252	4.56	No	Yes	2	7	9
678	C:C:L120	Q:Q:P23	3.28	No	Yes	2	7	9
679	C:C:L167	C:C:Y121	12.89	No	No	2	5	7
680	C:C:H203	C:C:Y121	5.44	Yes	No	2	4	7
681	C:C:V206	C:C:Y121	3.79	No	No	2	4	7
682	C:C:S122	C:C:V160	3.23	Yes	Yes	32	7	7
683	C:C:S122	C:C:W161	8.65	Yes	Yes	32	7	9
684	C:C:F248	C:C:S123	6.61	Yes	No	0	9	9
685	C:C:P211	C:C:V124	3.53	No	No	0	9	7
686	C:C:F248	C:C:V124	3.93	Yes	No	0	9	7
687	C:C:L125	C:C:V160	2.98	No	Yes	0	5	7
688	C:C:I126	C:C:I130	2.94	No	No	0	7	8
689	C:C:I126	C:C:V160	9.22	No	Yes	0	7	7
690	C:C:I245	C:C:L127	4.28	No	No	0	7	8
691	C:C:F248	C:C:L127	6.09	Yes	No	0	9	8
692	C:C:F129	C:C:L151	4.87	No	No	0	5	4
693	C:C:F129	C:C:G159	3.01	No	No	0	5	3
694	C:C:I215	C:C:S131	9.29	No	No	0	7	9
695	C:C:C218	C:C:S131	3.44	No	No	0	6	9
696	C:C:D133	C:C:R148	8.34	No	Yes	13	8	6
697	C:C:A137	C:C:R134	4.15	No	Yes	13	8	9
698	C:C:R134	C:C:R148	3.2	Yes	Yes	13	9	6
699	C:C:V139	C:C:Y135	6.31	No	Yes	33	7	8
700	C:C:H140	C:C:Y135	4.36	Yes	Yes	33	6	8
701	C:C:C218	C:C:Y135	4.03	No	Yes	0	6	8
702	C:C:I221	C:C:Y135	6.04	No	Yes	0	4	8
703	C:C:L136	C:C:S144	4.5	No	No	0	5	5
704	C:C:A137	C:C:R148	6.91	No	Yes	13	8	6
705	C:C:I138	C:C:I222	7.36	No	No	0	8	8
706	C:C:I138	C:C:K234	2.91	No	No	0	8	7
707	C:C:H140	C:C:V139	11.07	Yes	No	33	6	7
708	C:C:K225	C:C:V139	3.04	No	No	0	4	7
709	C:C:N143	C:C:T142	5.85	No	No	0	5	5
710	C:C:Q145	C:C:R146	8.18	No	No	0	5	5
711	C:C:E153	C:C:K149	4.05	No	No	0	7	6
712	C:C:K154	C:C:L150	4.23	No	No	0	3	4
713	C:C:L150	C:C:V155	2.98	No	No	0	4	2
714	C:C:I162	C:C:V158	4.61	No	No	0	4	4
715	C:C:V160	C:C:W161	3.68	Yes	Yes	32	7	9
716	C:C:I162	C:C:P163	3.39	No	No	0	4	4
717	C:C:L167	C:C:Q202	3.99	No	No	2	5	3
718	C:C:L167	C:C:V206	4.47	No	No	2	5	4
719	C:C:D171	C:C:T168	2.89	Yes	Yes	2	4	6
720	C:C:I169	C:C:P170	3.39	No	Yes	0	3	8
721	C:C:F174	C:C:P170	2.89	Yes	Yes	0	4	8
722	C:C:P170	C:C:R188	2.88	Yes	Yes	0	8	5
723	C:C:F199	C:C:P170	8.67	No	Yes	0	5	8
724	C:C:D171	C:C:R188	13.1	Yes	Yes	0	4	5
725	C:C:F174	C:C:I173	11.3	Yes	No	0	4	3
726	C:C:F174	C:C:Y190	7.22	Yes	Yes	14	4	4
727	C:C:F174	C:C:P191	4.33	Yes	No	14	4	5
728	C:C:F174	C:C:W195	5.01	Yes	Yes	14	4	5
729	C:C:I185	C:C:S178	3.1	No	No	0	3	1
730	C:C:F189	C:C:S178	5.28	Yes	No	0	3	1
731	C:C:S178	Q:Q:N54	2.98	No	No	0	1	8
732	C:C:E179	C:C:Y184	10.1	No	No	0	2	5
733	C:C:A180	C:C:I185	3.25	No	No	0	1	3
734	C:C:D181	C:C:R183	7.15	No	No	0	2	3
735	C:C:D187	C:C:F189	3.58	No	Yes	0	3	3
736	C:C:D187	Q:Q:S25	7.36	No	No	0	3	9
737	C:C:D187	Q:Q:S27	7.36	No	No	0	3	6
738	C:C:R188	C:C:Y190	17.49	Yes	Yes	0	5	4
739	C:C:R188	Q:Q:P23	4.32	Yes	Yes	0	5	9
740	C:C:F189	Q:Q:Y28	10.32	Yes	No	0	3	8
741	C:C:P191	C:C:Y190	4.17	No	Yes	14	5	4
742	C:C:W195	C:C:Y190	5.79	Yes	Yes	14	5	4
743	C:C:V196	C:C:Y190	7.57	No	Yes	0	4	4
744	C:C:F199	C:C:Y190	14.44	No	Yes	14	5	4
745	C:C:N192	C:C:P191	3.26	No	No	0	1	5
746	C:C:L194	C:C:N192	5.49	No	No	0	2	1
747	C:C:N192	C:C:W195	7.91	No	Yes	0	1	5
748	C:C:F199	C:C:W195	4.01	No	Yes	14	5	5
749	C:C:L266	C:C:V197	4.47	No	No	0	3	3
750	C:C:L267	C:C:V197	8.94	No	No	0	1	3
751	C:C:D262	C:C:Q200	6.53	No	No	0	5	5
752	C:C:Q200	C:C:S263	5.78	No	No	0	5	5
753	C:C:Q200	Q:Q:V24	5.73	No	Yes	0	5	7
754	C:C:F201	C:C:S263	6.61	No	No	0	4	5
755	C:C:F201	C:C:F264	4.29	No	No	0	4	4
756	C:C:Q202	C:C:V206	4.3	No	No	2	3	4
757	C:C:H203	C:C:Y255	6.53	Yes	Yes	2	4	7
758	C:C:H203	C:C:Y256	7.62	Yes	Yes	2	4	8
759	C:C:H203	Q:Q:P23	18.3	Yes	Yes	2	4	9
760	C:C:I204	C:C:I259	5.89	No	Yes	0	5	5
761	C:C:I209	C:C:M205	5.83	No	No	0	4	4
762	C:C:G207	C:C:Y256	2.9	No	Yes	0	5	8
763	C:C:L208	C:C:Y256	11.72	No	Yes	0	8	8
764	C:C:L210	C:C:P211	3.28	No	No	0	6	9
765	C:C:I215	C:C:I245	4.42	No	No	0	7	7
766	C:C:F249	C:C:I215	3.77	No	No	0	4	7
767	C:C:V242	C:C:Y219	7.57	No	No	0	4	8
768	C:C:I245	C:C:Y219	6.04	No	No	0	7	8
769	C:C:I222	C:C:L238	2.85	No	No	0	8	5
770	C:C:K225	C:C:S224	3.06	No	No	0	4	4
771	C:C:L226	C:C:S229	3	No	No	0	8	5
772	C:C:H232	C:C:K234	9.17	No	No	0	4	7
773	C:C:K236	C:C:Q233	10.85	No	No	0	8	5
774	C:C:K236	C:C:R235	3.71	No	No	0	8	5
775	C:C:T240	C:C:T241	3.14	No	No	0	7	7
776	C:C:I243	C:C:L301	4.28	No	No	0	5	7
777	C:C:A247	C:C:L297	4.73	No	No	0	6	6
778	C:C:F248	C:C:F249	3.22	Yes	No	0	9	4
779	C:C:F248	C:C:W252	13.03	Yes	Yes	2	9	9
780	C:C:F248	C:C:H294	7.92	Yes	Yes	2	9	9
781	C:C:W252	C:C:Y255	5.79	Yes	Yes	2	9	7
782	C:C:A291	C:C:W252	7.78	No	Yes	0	8	9
783	C:C:H294	C:C:W252	14.81	Yes	Yes	2	9	9
784	C:C:Y255	C:C:Y256	3.97	Yes	Yes	2	7	8
785	C:C:I259	C:C:Y255	9.67	Yes	Yes	2	5	7
786	C:C:T287	C:C:Y255	3.75	No	Yes	0	6	7
787	C:C:E288	C:C:Y255	5.61	No	Yes	0	5	7
788	C:C:Y255	Q:Q:V24	6.31	Yes	Yes	2	7	7
789	C:C:I259	C:C:Y256	3.63	Yes	Yes	2	5	8
790	C:C:I259	C:C:I284	2.94	Yes	No	0	5	4
791	C:C:I259	Q:Q:V24	4.61	Yes	Yes	2	5	7
792	C:C:D262	C:C:H281	3.78	No	Yes	0	5	4
793	C:C:F276	C:C:I265	3.77	Yes	No	0	1	3
794	C:C:E268	C:C:K271	4.05	No	No	0	2	3
795	C:C:E268	Q:Q:R33	11.63	No	No	0	2	9
796	C:C:I269	C:C:I270	5.89	No	No	0	1	5
797	C:C:F276	C:C:G273	3.01	Yes	No	0	1	5
798	C:C:C274	C:C:E275	3.04	No	No	0	5	3
799	C:C:F276	C:C:V280	5.24	Yes	No	0	1	5
800	C:C:E277	C:C:H281	14.77	No	Yes	0	2	4
801	C:C:N278	Q:Q:R29	3.62	No	No	0	3	9
802	C:C:H281	Q:Q:L26	10.29	Yes	No	0	4	9
803	C:C:H281	Q:Q:R29	3.39	Yes	No	0	4	9
804	C:C:T287	C:C:W283	10.92	No	Yes	0	6	6
805	C:C:I284	Q:Q:L26	2.85	No	No	0	4	9
806	C:C:E288	C:C:F292	4.66	No	Yes	0	5	7
807	C:C:E288	Q:Q:K22	9.45	No	Yes	0	5	9
808	C:C:C296	C:C:F293	5.59	No	Yes	0	7	5
809	C:C:C295	C:C:H294	7.37	No	Yes	0	9	9
810	C:C:N298	C:C:P299	4.89	Yes	No	0	9	9
811	P:P:K25	U:U:F34	3.72	No	No	0	4	6
812	P:P:K25	U:U:V70	3.04	No	No	0	4	9
813	P:P:E26	P:P:P27	7.86	No	Yes	0	2	5
814	P:P:E26	P:P:F29	4.66	No	No	0	2	4
815	P:P:P27	U:U:C71	3.77	Yes	No	0	5	9
816	P:P:C28	U:U:P31	7.53	No	No	0	9	7
817	P:P:H281	P:P:R30	5.64	No	No	0	4	5
818	P:P:R30	U:U:R29	3.2	No	No	0	5	9
819	P:P:E31	P:P:E32	3.81	Yes	No	34	5	4
820	P:P:E31	P:P:N33	10.52	Yes	No	34	5	6
821	P:P:E31	P:P:N278	5.26	Yes	No	0	5	3
822	P:P:E31	P:P:K282	4.05	Yes	No	0	5	2
823	P:P:E32	P:P:N33	3.94	No	No	34	4	6
824	P:P:N33	P:P:N35	8.17	No	Yes	0	6	3
825	P:P:F36	P:P:F40	7.5	No	No	0	4	5
826	P:P:N37	P:P:S285	4.47	Yes	No	0	3	5
827	P:P:I286	P:P:N37	4.25	No	Yes	0	6	3
828	P:P:F40	P:P:I44	8.79	No	No	0	5	5
829	P:P:L41	P:P:Y45	5.86	No	Yes	0	6	7
830	P:P:A289	P:P:L41	3.15	No	No	0	4	6
831	P:P:P42	P:P:V99	5.3	No	No	11	5	4
832	P:P:I44	P:P:I48	2.94	No	No	0	5	7
833	P:P:L91	P:P:Y45	3.52	Yes	Yes	0	8	7
834	P:P:W94	P:P:Y45	2.89	Yes	Yes	0	7	7
835	P:P:A95	P:P:Y45	4	No	Yes	0	7	7
836	P:P:F292	P:P:Y45	7.22	Yes	Yes	0	7	7
837	P:P:I48	P:P:L91	2.85	No	Yes	0	7	8
838	P:P:F293	P:P:I48	12.56	Yes	No	0	5	7
839	P:P:F49	P:P:L50	3.65	No	No	0	6	5
840	P:P:F49	P:P:L91	3.65	No	Yes	0	6	8
841	P:P:F49	P:P:P92	7.22	No	No	0	6	9
842	P:P:C296	P:P:T51	6.76	No	No	0	7	5
843	P:P:G52	P:P:V88	5.52	No	No	0	8	6
844	P:P:G55	P:P:V54	3.68	No	No	0	8	4
845	P:P:G55	P:P:P299	4.06	No	Yes	0	8	9
846	P:P:N56	P:P:S81	4.47	Yes	No	0	9	9
847	P:P:D84	P:P:N56	12.12	No	Yes	0	9	9
848	P:P:N56	P:P:V88	2.96	Yes	No	0	9	6
849	P:P:N56	P:P:P299	3.26	Yes	Yes	0	9	9
850	P:P:S81	P:P:V59	8.08	No	No	0	9	8
851	P:P:P299	P:P:V59	3.53	Yes	No	0	9	8
852	P:P:I60	P:P:V82	3.07	No	No	0	7	5
853	P:P:I60	P:P:L85	2.85	No	No	0	7	7
854	P:P:M63	P:P:V62	3.04	No	No	0	6	7
855	P:P:K68	P:P:V62	4.55	No	No	0	6	7
856	P:P:D74	P:P:M63	6.93	No	No	35	8	6
857	P:P:M63	P:P:Y302	8.38	No	No	35	6	9
858	P:P:G64	P:P:L78	3.42	No	No	0	2	5
859	P:P:K68	P:P:R70	3.71	No	No	0	6	6
860	P:P:K75	P:P:L69	7.05	No	No	0	6	6
861	P:P:S71	P:P:T73	3.2	No	No	0	7	7
862	P:P:D74	P:P:S71	5.89	No	No	0	8	7
863	P:P:M72	P:P:R148	3.72	No	No	0	6	6
864	P:P:A152	P:P:M72	3.22	No	No	0	3	6
865	P:P:R134	P:P:T73	3.88	Yes	No	0	9	7
866	P:P:D74	P:P:Y302	6.9	No	No	35	8	9
867	P:P:E153	P:P:K75	9.45	No	No	0	7	6
868	P:P:I126	P:P:Y76	3.63	Yes	Yes	8	7	7
869	P:P:F129	P:P:Y76	3.09	No	Yes	0	5	7
870	P:P:I130	P:P:Y76	4.84	No	Yes	8	8	7
871	P:P:D133	P:P:Y76	8.05	No	Yes	0	8	7
872	P:P:V156	P:P:Y76	3.79	No	Yes	0	5	7
873	P:P:N298	P:P:R77	3.62	Yes	No	0	9	8
874	P:P:R77	P:P:Y302	30.87	No	No	0	8	9
875	P:P:H79	P:P:Y157	4.36	No	No	0	9	7
876	P:P:H79	P:P:W161	5.29	No	Yes	0	9	9
877	P:P:I126	P:P:L80	4.28	Yes	No	0	7	9
878	P:P:L80	P:P:N298	5.49	No	Yes	0	9	9
879	P:P:N298	P:P:S81	4.47	Yes	No	0	9	9
880	P:P:A83	P:P:S122	3.42	No	Yes	0	8	7
881	P:P:C295	P:P:D84	9.34	No	No	0	9	9
882	P:P:F87	P:P:L91	3.65	Yes	Yes	0	7	8
883	P:P:F87	P:P:Y116	8.25	Yes	No	5	7	6
884	P:P:F87	P:P:N119	9.67	Yes	No	0	7	8
885	P:P:F292	P:P:F87	15	Yes	Yes	5	7	7
886	P:P:C295	P:P:V88	3.42	No	No	0	9	6
887	P:P:I89	P:P:T90	3.04	No	No	0	4	6
888	P:P:T90	P:P:V112	9.52	No	Yes	0	6	5
889	P:P:I115	P:P:T90	7.6	No	No	0	5	6
890	P:P:F104	P:P:F93	10.72	No	No	0	7	6
891	P:P:F93	P:P:L108	3.65	No	No	0	6	5
892	P:P:F93	P:P:V112	3.93	No	Yes	0	6	5
893	P:P:V112	P:P:W94	6.13	Yes	Yes	0	5	7
894	P:P:H113	P:P:W94	6.35	Yes	Yes	5	6	7
895	P:P:W94	U:U:K22	13.92	Yes	Yes	5	7	9
896	P:P:F104	P:P:V96	5.24	No	No	0	7	5
897	P:P:D97	P:P:W102	7.82	No	Yes	0	5	9
898	P:P:N101	P:P:R183	20.49	No	No	0	4	3
899	P:P:F104	P:P:W102	18.04	No	Yes	0	7	9
900	P:P:C109	P:P:W102	3.92	No	Yes	5	9	9
901	P:P:V112	P:P:W102	3.68	Yes	Yes	0	5	9
902	P:P:C186	P:P:W102	16.98	No	Yes	5	9	9
903	P:P:C109	P:P:H113	2.95	No	Yes	5	9	6
904	P:P:C109	P:P:C186	7.28	No	No	5	9	9
905	P:P:K110	P:P:N176	6.99	No	No	0	7	4
906	P:P:D171	P:P:H113	3.78	No	Yes	0	4	6
907	P:P:A175	P:P:H113	4.39	No	Yes	0	4	6
908	P:P:C186	P:P:H113	2.95	No	Yes	5	9	6
909	P:P:H113	U:U:K22	5.24	Yes	Yes	5	6	9
910	P:P:T168	P:P:V114	4.76	No	No	0	6	5
911	P:P:F172	P:P:V114	10.49	No	No	0	4	5
912	P:P:F292	P:P:Y116	8.25	Yes	No	5	7	6
913	P:P:Y116	U:U:K22	7.17	No	Yes	5	6	9
914	P:P:T117	P:P:T168	3.14	No	No	0	5	6
915	P:P:D171	P:P:T117	11.56	No	No	0	4	5
916	P:P:T117	U:U:P23	5.25	No	Yes	0	5	9
917	P:P:T168	P:P:V118	3.17	No	No	0	6	5
918	P:P:H294	P:P:N119	3.83	Yes	No	0	9	8
919	P:P:H203	P:P:L120	6.43	Yes	No	4	4	7
920	P:P:L120	P:P:W252	4.56	No	Yes	4	7	9
921	P:P:L120	U:U:P23	3.28	No	Yes	4	7	9
922	P:P:L167	P:P:Y121	11.72	No	No	4	5	7
923	P:P:H203	P:P:Y121	5.44	Yes	No	4	4	7
924	P:P:V206	P:P:Y121	3.79	No	No	4	4	7
925	P:P:S122	P:P:V160	3.23	Yes	Yes	8	7	7
926	P:P:S122	P:P:W161	8.65	Yes	Yes	8	7	9
927	P:P:F248	P:P:S123	6.61	Yes	No	0	9	9
928	P:P:P211	P:P:V124	3.53	No	No	0	9	7
929	P:P:F248	P:P:V124	3.93	Yes	No	0	9	7
930	P:P:L125	P:P:V160	2.98	No	Yes	0	5	7
931	P:P:I126	P:P:I130	2.94	Yes	No	8	7	8
932	P:P:I126	P:P:V160	9.22	Yes	Yes	8	7	7
933	P:P:I245	P:P:L127	4.28	No	No	0	7	8
934	P:P:F248	P:P:L127	6.09	Yes	No	0	9	8
935	P:P:F129	P:P:G159	3.01	No	No	0	5	3
936	P:P:I215	P:P:S131	9.29	No	No	0	7	9
937	P:P:C218	P:P:S131	3.44	No	No	0	6	9
938	P:P:D133	P:P:R148	11.91	No	No	0	8	6
939	P:P:A137	P:P:R134	4.15	No	Yes	0	8	9
940	P:P:V139	P:P:Y135	6.31	No	Yes	36	7	8
941	P:P:H140	P:P:Y135	3.27	Yes	Yes	36	6	8
942	P:P:C218	P:P:Y135	4.03	No	Yes	0	6	8
943	P:P:I221	P:P:Y135	6.04	No	Yes	0	4	8
944	P:P:H140	P:P:L136	3.86	Yes	No	0	6	5
945	P:P:L136	P:P:S144	4.5	No	No	0	5	5
946	P:P:A137	P:P:R148	6.91	No	No	0	8	6
947	P:P:I138	P:P:I222	7.36	No	No	0	8	8
948	P:P:H140	P:P:V139	11.07	Yes	No	36	6	7
949	P:P:K225	P:P:V139	3.04	No	No	0	4	7
950	P:P:N143	P:P:T142	5.85	No	No	0	5	5
951	P:P:Q145	P:P:R146	8.18	No	No	0	5	5
952	P:P:E153	P:P:K149	4.05	No	No	0	7	6
953	P:P:K154	P:P:L150	4.23	No	No	0	3	4
954	P:P:I162	P:P:V158	4.61	No	No	0	4	4
955	P:P:V160	P:P:W161	3.68	Yes	Yes	8	7	9
956	P:P:I162	P:P:P163	3.39	No	No	0	4	4
957	P:P:L167	P:P:Q202	3.99	No	No	4	5	3
958	P:P:L167	P:P:V206	4.47	No	No	4	5	4
959	P:P:I169	P:P:P170	3.39	No	Yes	0	3	8
960	P:P:F174	P:P:P170	2.89	Yes	Yes	0	4	8
961	P:P:P170	P:P:R188	2.88	Yes	Yes	0	8	5
962	P:P:F199	P:P:P170	8.67	No	Yes	0	5	8
963	P:P:D171	P:P:R188	13.1	No	Yes	0	4	5
964	P:P:F174	P:P:I173	11.3	Yes	No	0	4	3
965	P:P:F174	P:P:Y190	6.19	Yes	Yes	15	4	4
966	P:P:F174	P:P:P191	4.33	Yes	No	15	4	5
967	P:P:F174	P:P:W195	5.01	Yes	Yes	15	4	5
968	P:P:I185	P:P:S178	3.1	Yes	No	37	3	1
969	P:P:F189	P:P:S178	6.61	Yes	No	37	3	1
970	P:P:S178	U:U:N54	2.98	No	No	0	1	8
971	P:P:E179	P:P:Y184	13.47	No	No	0	2	5
972	P:P:D181	P:P:R183	5.96	No	No	0	2	3
973	P:P:F189	P:P:I185	5.02	Yes	Yes	37	3	3
974	P:P:I185	U:U:S27	3.1	Yes	No	0	3	6
975	P:P:D187	U:U:S25	8.83	No	No	0	3	9
976	P:P:D187	U:U:S27	5.89	No	No	0	3	6
977	P:P:R188	P:P:Y190	12.35	Yes	Yes	0	5	4
978	P:P:R188	U:U:P23	4.32	Yes	Yes	0	5	9
979	P:P:F189	U:U:Y28	8.25	Yes	No	0	3	8
980	P:P:P191	P:P:Y190	4.17	No	Yes	15	5	4
981	P:P:W195	P:P:Y190	6.75	Yes	Yes	15	5	4
982	P:P:V196	P:P:Y190	7.57	No	Yes	0	4	4
983	P:P:F199	P:P:Y190	12.38	No	Yes	15	5	4
984	P:P:N192	P:P:P191	3.26	No	No	0	1	5
985	P:P:L194	P:P:N192	5.49	No	No	0	2	1
986	P:P:N192	P:P:W195	9.04	No	Yes	0	1	5
987	P:P:F199	P:P:W195	4.01	No	Yes	15	5	5
988	P:P:L266	P:P:V197	4.47	No	No	0	3	3
989	P:P:L267	P:P:V197	8.94	No	No	0	1	3
990	P:P:D262	P:P:Q200	6.53	No	Yes	0	5	5
991	P:P:Q200	P:P:S263	4.33	Yes	No	0	5	5
992	P:P:Q200	U:U:V24	4.3	Yes	No	0	5	7
993	P:P:F201	P:P:S263	7.93	No	No	0	4	5
994	P:P:F201	P:P:F264	3.22	No	No	0	4	4
995	P:P:Q202	P:P:V206	4.3	No	No	4	3	4
996	P:P:H203	P:P:Y255	6.53	Yes	Yes	4	4	7
997	P:P:H203	P:P:Y256	6.53	Yes	Yes	4	4	8
998	P:P:H203	U:U:P23	15.25	Yes	Yes	4	4	9
999	P:P:I204	P:P:I259	5.89	No	Yes	0	5	5
1000	P:P:I209	P:P:M205	5.83	No	No	0	4	4
1001	P:P:G207	P:P:Y256	2.9	No	Yes	0	5	8
1002	P:P:L208	P:P:Y256	11.72	No	Yes	0	8	8
1003	P:P:I215	P:P:I245	4.42	No	No	0	7	7
1004	P:P:F249	P:P:I215	3.77	No	No	0	4	7
1005	P:P:V242	P:P:Y219	7.57	No	No	0	4	8
1006	P:P:I245	P:P:Y219	6.04	No	No	0	7	8
1007	P:P:I222	P:P:L238	2.85	No	No	0	8	5
1008	P:P:K225	P:P:S224	3.06	No	No	0	4	4
1009	P:P:L226	P:P:S229	3	No	No	0	8	5
1010	P:P:K234	P:P:S229	4.59	No	No	0	7	5
1011	P:P:H232	P:P:K234	14.41	No	No	0	4	7
1012	P:P:K236	P:P:Q233	10.85	No	No	0	8	5
1013	P:P:K236	P:P:R235	3.71	No	No	0	8	5
1014	P:P:T240	P:P:T241	3.14	No	No	0	7	7
1015	P:P:I243	P:P:L301	4.28	No	No	0	5	7
1016	P:P:A247	P:P:L297	4.73	No	No	0	6	6
1017	P:P:F248	P:P:F249	3.22	Yes	No	0	9	4
1018	P:P:F248	P:P:W252	13.03	Yes	Yes	4	9	9
1019	P:P:F248	P:P:H294	7.92	Yes	Yes	4	9	9
1020	P:P:W252	P:P:Y255	6.75	Yes	Yes	4	9	7
1021	P:P:A291	P:P:W252	7.78	No	Yes	0	8	9
1022	P:P:H294	P:P:W252	14.81	Yes	Yes	4	9	9
1023	P:P:P254	P:P:T287	3.5	No	No	0	9	6
1024	P:P:Y255	P:P:Y256	3.97	Yes	Yes	4	7	8
1025	P:P:I259	P:P:Y255	9.67	Yes	Yes	4	5	7
1026	P:P:T287	P:P:Y255	3.75	No	Yes	0	6	7
1027	P:P:E288	P:P:Y255	5.61	No	Yes	0	5	7
1028	P:P:Y255	U:U:V24	5.05	Yes	No	0	7	7
1029	P:P:I259	P:P:Y256	3.63	Yes	Yes	4	5	8
1030	P:P:I259	P:P:I284	4.42	Yes	No	0	5	4
1031	P:P:I261	P:P:V280	3.07	Yes	No	0	5	5
1032	P:P:D262	P:P:E277	3.9	No	Yes	0	5	2
1033	P:P:I265	P:P:I270	4.42	No	No	0	3	5
1034	P:P:F276	P:P:I265	3.77	Yes	No	0	1	3
1035	P:P:E277	P:P:I265	4.1	Yes	No	0	2	3
1036	P:P:E268	P:P:K271	4.05	No	No	0	2	3
1037	P:P:E268	U:U:R33	15.12	No	No	0	2	9
1038	P:P:I269	P:P:I270	4.42	No	No	0	1	5
1039	P:P:I270	P:P:Q272	5.49	No	No	0	5	2
1040	P:P:F276	P:P:G273	3.01	Yes	No	0	1	5
1041	P:P:F276	P:P:V280	6.55	Yes	No	0	1	5
1042	P:P:E277	P:P:H281	14.77	Yes	No	0	2	4
1043	P:P:E277	U:U:R29	5.82	Yes	No	0	2	9
1044	P:P:I284	P:P:V280	3.07	No	No	0	4	5
1045	P:P:H281	U:U:L26	6.43	No	No	0	4	9
1046	P:P:T287	P:P:W283	9.7	No	Yes	0	6	6
1047	P:P:E288	P:P:F292	3.5	No	Yes	0	5	7
1048	P:P:E288	U:U:K22	9.45	No	Yes	0	5	9
1049	P:P:C296	P:P:F293	5.59	No	Yes	0	7	5
1050	P:P:C295	P:P:H294	7.37	No	Yes	0	9	9
1051	P:P:N298	P:P:P299	4.89	Yes	Yes	0	9	9
1052	Y:Y:K22	Y:Y:V24	7.59	No	No	38	9	7
1053	Y:Y:K22	Y:Y:L26	4.23	No	No	38	9	9
1054	Y:Y:L26	Y:Y:V24	4.47	No	No	38	9	7
1055	Y:Y:C55	Y:Y:Y28	6.72	No	No	0	9	8
1056	Y:Y:C30	Y:Y:C32	7.28	No	No	0	9	9
1057	Y:Y:C55	Y:Y:T52	3.38	No	No	0	9	8
1058	J:J:K22	J:J:V24	7.59	No	No	39	9	7
1059	J:J:K22	J:J:L26	4.23	No	No	39	9	9
1060	J:J:L26	J:J:V24	4.47	No	No	39	9	7
1061	J:J:C55	J:J:Y28	6.72	No	No	0	9	8
1062	J:J:C30	J:J:C32	7.28	No	No	0	9	9
1063	J:J:C55	J:J:T52	3.38	No	No	0	9	8
1064	N:N:K22	N:N:V24	4.55	No	No	0	9	7
1065	N:N:L26	N:N:V24	8.94	No	No	0	9	7
1066	N:N:C55	N:N:Y28	6.72	No	No	0	9	8
1067	N:N:R29	N:N:R33	3.2	No	No	0	9	9
1068	N:N:C30	N:N:C32	7.28	No	No	0	9	9
1069	N:N:C55	N:N:T52	3.38	No	No	0	9	8
1070	Q:Q:K22	Q:Q:P23	3.35	Yes	Yes	0	9	9
1071	Q:Q:K22	Q:Q:V24	3.04	Yes	Yes	0	9	7
1072	Q:Q:S25	Q:Q:Y28	5.09	No	No	0	9	8
1073	Q:Q:C30	Q:Q:C32	7.28	No	No	0	9	9
1074	Q:Q:C30	Q:Q:C55	3.64	No	No	0	9	9
1075	U:U:S25	U:U:Y28	5.09	No	No	0	9	8
1076	U:U:C30	U:U:C32	7.28	No	No	0	9	9
1077	U:U:C30	U:U:C55	3.64	No	No	0	9	9
1078	L:L:S25	L:L:Y28	5.09	No	No	0	9	8
1079	L:L:L26	L:L:R29	3.64	Yes	Yes	1	9	9
1080	L:L:R29	L:L:R33	6.4	Yes	No	0	9	9
1081	L:L:C30	L:L:C32	7.28	No	No	0	9	9
1082	L:L:C30	L:L:C55	7.28	No	No	0	9	9
1083	L:L:F34	L:L:R33	3.21	No	No	0	6	9
1084	L:L:C55	L:L:T52	3.38	No	No	0	9	8
1085	S:S:L210	S:S:M205	2.83	No	No	0	6	4
1086	R:R:L210	R:R:M205	2.83	No	No	0	6	4
1087	C:C:L210	C:C:M205	2.83	No	No	0	6	4
1088	P:P:L210	P:P:M205	2.83	No	No	0	6	4
1089	S:S:G258	S:S:W283	2.81	No	Yes	0	4	6
1090	R:R:G258	R:R:W283	2.81	No	Yes	0	4	6
1091	C:C:G258	C:C:W283	2.81	No	Yes	0	4	6
1092	P:P:G258	P:P:W283	2.81	No	Yes	0	4	6
1093	S:S:K282	S:S:N37	2.8	No	Yes	0	2	3
1094	S:S:H140	S:S:S144	2.79	Yes	No	0	6	5
1095	S:S:H232	S:S:S229	2.79	No	No	0	4	5
1096	C:C:C28	C:C:R30	2.79	No	No	0	9	5
1097	C:C:H140	C:C:S144	2.79	Yes	No	0	6	5
1098	P:P:C28	P:P:R30	2.79	No	No	0	9	5
1099	N:N:C71	N:N:F34	2.79	No	No	0	9	6
1100	R:R:L253	S:S:L50	2.77	No	No	0	5	5
1101	S:S:L127	S:S:L244	2.77	No	No	0	8	7
1102	S:S:L132	S:S:L136	2.77	No	No	0	6	5
1103	S:S:L208	S:S:L253	2.77	No	No	0	8	5
1104	P:P:L50	S:S:L253	2.77	No	No	0	5	5
1105	R:R:L127	R:R:L244	2.77	No	No	0	8	7
1106	R:R:L132	R:R:L136	2.77	No	Yes	0	6	5
1107	R:R:L208	R:R:L253	2.77	No	No	0	8	5
1108	R:R:L244	R:R:L297	2.77	No	No	0	7	6
1109	C:C:L50	P:P:L253	2.77	No	No	0	5	5
1110	C:C:H79	C:C:V156	2.77	No	No	0	9	5
1111	C:C:L132	C:C:L136	2.77	No	No	0	6	5
1112	C:C:A180	C:C:R183	2.77	No	No	0	1	3
1113	C:C:L208	C:C:L253	2.77	No	No	0	8	5
1114	P:P:L127	P:P:L244	2.77	No	No	0	8	7
1115	P:P:A180	P:P:R183	2.77	No	No	0	1	3
1116	P:P:L208	P:P:L253	2.77	No	No	0	8	5
1117	S:S:L41	S:S:N37	2.75	No	Yes	0	6	3
1118	R:R:L85	R:R:N56	2.75	No	No	0	7	9
1119	P:P:L41	P:P:N37	2.75	No	Yes	0	6	3
1120	S:S:N106	S:S:N176	2.72	No	No	0	3	4
1121	C:C:N106	C:C:N176	2.72	No	No	0	3	4
1122	P:P:N106	P:P:N176	2.72	No	No	0	3	4
1123	R:R:D262	R:R:L266	2.71	Yes	No	0	5	3
1124	L:L:L26	R:R:D262	2.71	Yes	Yes	1	9	5
1125	R:R:E153	R:R:K154	2.7	No	No	0	7	3
1126	S:S:C218	S:S:Y135	2.69	No	Yes	0	6	8
1127	S:S:A98	S:S:Y45	2.67	No	Yes	0	5	7
1128	R:R:A95	R:R:Y45	2.67	No	Yes	0	7	7
1129	R:R:A100	R:R:Y103	2.67	No	No	0	5	3
1130	P:P:A98	P:P:Y45	2.67	No	Yes	0	5	7
1131	S:S:F264	S:S:S260	2.64	No	No	0	4	5
1132	R:R:F264	R:R:S260	2.64	No	No	0	4	5
1133	C:C:R188	Q:Q:S25	2.64	Yes	No	0	5	9
1134	C:C:F264	C:C:S260	2.64	No	No	0	4	5
1135	P:P:F264	P:P:S260	2.64	No	No	0	4	5
1136	P:P:N35	S:S:E275	2.63	Yes	No	0	3	3
1137	C:C:E275	R:R:N35	2.63	No	Yes	0	3	3
1138	R:R:F276	S:S:V99	2.62	Yes	No	0	1	4
1139	R:R:F248	R:R:V124	2.62	Yes	No	0	9	7
1140	C:C:H232	C:C:K230	2.62	No	No	0	4	5
1141	P:P:H232	P:P:K230	2.62	No	No	0	4	5
1142	S:S:R134	S:S:T241	2.59	Yes	No	0	9	7
1143	R:R:F172	R:R:T168	2.59	No	No	0	4	6
1144	C:C:R134	C:C:T241	2.59	Yes	No	0	9	7
1145	P:P:R134	P:P:T241	2.59	Yes	No	0	9	7
1146	S:S:H140	S:S:N143	2.55	Yes	No	0	6	5
1147	R:R:H281	R:R:N278	2.55	Yes	No	0	4	3
1148	C:C:H140	C:C:N143	2.55	Yes	No	0	6	5
1149	P:P:H140	P:P:N143	2.55	Yes	No	0	6	5
1150	S:S:F304	S:S:I300	2.51	No	No	0	6	6
1151	R:R:F304	R:R:I300	2.51	No	No	0	6	6
1152	C:C:F304	C:C:I300	2.51	No	No	0	6	6
1153	P:P:F304	P:P:I300	2.51	No	No	0	6	6
1154	S:S:V118	S:S:W161	2.45	No	Yes	0	5	9
1155	R:R:V82	R:R:W161	2.45	No	Yes	0	5	9
1156	R:R:V118	R:R:W161	2.45	No	Yes	0	5	9
1157	C:C:V82	C:C:W161	2.45	No	Yes	0	5	9
1158	P:P:V82	P:P:W161	2.45	No	Yes	0	5	9
1159	S:S:F107	S:S:L108	2.44	No	No	0	1	5
1160	S:S:F293	S:S:L290	2.44	Yes	No	0	5	7
1161	R:R:F49	R:R:L50	2.44	No	No	0	6	5
1162	R:R:F129	R:R:L151	2.44	Yes	No	0	5	4
1163	R:R:F201	R:R:L267	2.44	No	No	0	4	1
1164	C:C:F107	C:C:L108	2.44	No	No	0	1	5
1165	C:C:F293	C:C:L290	2.44	Yes	No	0	5	7
1166	P:P:F107	P:P:L108	2.44	No	No	0	1	5
1167	P:P:F129	P:P:L151	2.44	No	No	0	5	4
1168	P:P:F293	P:P:L290	2.44	Yes	No	0	5	7
1169	M:M:R29	S:S:L266	2.43	Yes	No	0	9	3
1170	R:R:L301	R:R:R77	2.43	No	No	0	7	8
1171	R:R:L238	R:R:R134	2.43	No	Yes	0	5	9
1172	C:C:L238	C:C:R134	2.43	No	Yes	0	5	9
1173	P:P:L238	P:P:R134	2.43	No	Yes	0	5	9
1174	S:S:F189	S:S:N176	2.42	No	No	0	3	4
1175	C:C:F189	C:C:N176	2.42	Yes	No	0	3	4
1176	P:P:F189	P:P:N176	2.42	Yes	No	0	3	4
1177	R:R:L61	R:R:Y65	2.34	No	No	0	4	5
1178	U:U:F34	U:U:R33	2.14	No	No	0	6	9
1179	Y:Y:R29	Y:Y:R33	2.13	No	No	0	9	9
1180	U:U:R29	U:U:R33	2.13	No	No	0	9	9
1181	S:S:G159	S:S:P163	2.03	No	No	0	3	4
1182	C:C:G159	C:C:P163	2.03	No	No	0	3	4
1183	P:P:G159	P:P:P163	2.03	No	No	0	3	4
1184	P:P:Y190	U:U:Y28	1.99	Yes	No	0	4	8
1185	M:M:P31	S:S:P27	1.95	No	No	0	7	5
1186	C:C:P27	Q:Q:P31	1.95	Yes	No	0	5	7
1187	P:P:P27	U:U:P31	1.95	Yes	No	0	5	7
1188	L:L:P31	R:R:C28	1.88	No	No	0	7	9
1189	M:M:C30	M:M:P31	1.88	No	No	0	9	7
1190	q:q:C30	q:q:P31	1.88	No	No	28	9	7
1191	q:q:C32	q:q:P31	1.88	No	No	28	9	7
1192	Y:Y:C30	Y:Y:P31	1.88	No	No	0	9	7
1193	J:J:C30	J:J:P31	1.88	No	No	0	9	7
1194	N:N:C30	N:N:P31	1.88	No	No	0	9	7
1195	Q:Q:C30	Q:Q:P31	1.88	No	No	0	9	7
1196	U:U:C30	U:U:P31	1.88	No	No	0	9	7
1197	L:L:C30	L:L:P31	1.88	No	No	0	9	7
1198	S:S:A128	S:S:P211	1.87	No	No	0	7	9
1199	C:C:A128	C:C:P211	1.87	No	No	0	7	9
1200	P:P:A128	P:P:P211	1.87	No	No	0	7	9
1201	S:S:G231	S:S:S229	1.86	No	No	0	4	5
1202	P:P:G231	P:P:S229	1.86	No	No	0	4	5
1203	R:R:G52	R:R:V88	1.84	No	No	0	8	6
1204	N:N:C30	N:N:C55	1.82	No	No	0	9	9
1205	q:q:A56	q:q:C32	1.81	No	No	0	6	9
1206	Y:Y:A56	Y:Y:C32	1.81	No	No	0	6	9
1207	J:J:A56	J:J:C32	1.81	No	No	0	6	9
1208	N:N:A56	N:N:C32	1.81	No	No	0	6	9
1209	Q:Q:A56	Q:Q:C32	1.81	No	No	0	6	9
1210	C:C:P27	Q:Q:V60	1.77	Yes	No	0	5	8
1211	P:P:P27	U:U:V60	1.77	Yes	No	0	5	8
1212	R:R:G64	R:R:M63	1.75	No	Yes	0	2	6
1213	S:S:G55	S:S:L58	1.71	No	No	0	8	5
1214	S:S:A83	S:S:S122	1.71	No	Yes	0	8	7
1215	S:S:A164	S:S:S122	1.71	No	Yes	0	7	7
1216	S:S:A180	S:S:S178	1.71	No	Yes	0	1	1
1217	R:R:G55	R:R:L58	1.71	No	No	0	8	5
1218	R:R:A164	R:R:S122	1.71	No	Yes	0	7	7
1219	R:R:C218	R:R:V214	1.71	No	No	0	6	6
1220	R:R:G306	R:R:L301	1.71	No	No	0	8	7
1221	C:C:A83	C:C:S122	1.71	No	Yes	0	8	7
1222	C:C:A164	C:C:S122	1.71	No	Yes	0	7	7
1223	C:C:C218	C:C:V214	1.71	No	No	0	6	6
1224	P:P:G55	P:P:L58	1.71	No	No	0	8	5
1225	P:P:A164	P:P:S122	1.71	No	Yes	0	7	7
1226	P:P:C218	P:P:V214	1.71	No	No	0	6	6
1227	L:L:C71	L:L:V60	1.71	No	No	0	9	8
1228	Q:Q:C55	Q:Q:T52	1.69	No	No	0	9	8
1229	q:q:K22	q:q:P23	1.67	No	No	0	9	9
1230	Y:Y:K22	Y:Y:P23	1.67	No	No	0	9	9
1231	J:J:K22	J:J:P23	1.67	No	No	0	9	9
1232	N:N:K22	N:N:P23	1.67	No	No	0	9	9
1233	S:S:L210	S:S:P211	1.64	No	No	0	6	9
1234	S:S:C296	S:S:I300	1.64	No	No	0	7	6
1235	R:R:C296	R:R:I300	1.64	No	No	0	7	6
1236	C:C:C296	C:C:I300	1.64	No	No	0	7	6
1237	P:P:L210	P:P:P211	1.64	No	No	0	6	9
1238	P:P:C296	P:P:I300	1.64	No	No	0	7	6
1239	Y:Y:L57	Y:Y:P74	1.64	No	No	0	7	8
1240	N:N:L57	N:N:P74	1.64	No	No	0	7	8
1241	R:R:S227	S:S:V62	1.62	No	No	0	4	7
1242	q:q:A61	q:q:I72	1.62	No	No	0	9	6
1243	P:P:A180	P:P:I185	1.62	No	Yes	0	1	3
1244	S:S:A175	S:S:K110	1.61	No	No	0	4	7
1245	R:R:A152	R:R:K75	1.61	No	No	0	3	6
1246	P:P:A152	P:P:K75	1.61	No	No	0	3	6
1247	S:S:V155	S:S:V158	1.6	No	No	0	2	4
1248	C:C:V155	C:C:V158	1.6	No	No	0	2	4
1249	P:P:V155	P:P:V158	1.6	No	No	0	2	4
1250	R:R:C220	S:S:L58	1.59	No	No	0	3	5
1251	P:P:L58	S:S:C220	1.59	No	No	0	5	3
1252	S:S:C251	S:S:L297	1.59	No	No	0	8	6
1253	C:C:C220	R:R:L58	1.59	No	No	0	3	5
1254	R:R:G231	R:R:H232	1.59	No	No	0	4	4
1255	C:C:L58	P:P:C220	1.59	No	No	0	5	3
1256	C:C:C251	C:C:L297	1.59	No	No	0	8	6
1257	P:P:C251	P:P:L297	1.59	No	No	0	8	6
1258	L:L:Q69	R:R:P27	1.58	No	No	0	9	5
1259	M:M:A61	M:M:L47	1.58	No	No	0	9	9
1260	J:J:A86	M:M:L57	1.58	No	No	0	8	7
1261	J:J:L57	M:M:A86	1.58	No	No	0	7	8
1262	q:q:P31	q:q:Q58	1.58	No	No	0	7	9
1263	q:q:A61	q:q:L47	1.58	No	No	0	9	9
1264	Q:Q:A86	q:q:L57	1.58	No	No	0	8	7
1265	Q:Q:L57	q:q:A86	1.58	No	No	0	7	8
1266	Y:Y:P31	Y:Y:Q58	1.58	No	No	0	7	9
1267	Y:Y:A61	Y:Y:L47	1.58	No	No	0	9	9
1268	U:U:A86	Y:Y:L57	1.58	No	No	0	8	7
1269	U:U:L57	Y:Y:A86	1.58	No	No	0	7	8
1270	J:J:P31	J:J:Q58	1.58	No	No	0	7	9
1271	J:J:A61	J:J:L47	1.58	No	No	0	9	9
1272	N:N:A61	N:N:L47	1.58	No	No	0	9	9
1273	L:L:A86	N:N:L57	1.58	No	No	0	8	7
1274	L:L:L57	N:N:A86	1.58	No	No	0	7	8
1275	Q:Q:A61	Q:Q:L47	1.58	No	No	0	9	9
1276	U:U:A61	U:U:L47	1.58	No	No	0	9	9
1277	L:L:A61	L:L:L47	1.58	No	No	0	9	9
1278	R:R:E26	R:R:P27	1.57	No	No	0	2	5
1279	M:M:A40	M:M:N43	1.56	No	No	0	5	5
1280	q:q:A40	q:q:N43	1.56	No	No	0	5	5
1281	P:P:A34	P:P:N37	1.56	No	Yes	0	1	3
1282	P:P:D193	U:U:C32	1.56	No	No	0	1	9
1283	Y:Y:A40	Y:Y:N43	1.56	No	No	0	5	5
1284	J:J:A40	J:J:N43	1.56	No	No	0	5	5
1285	N:N:A40	N:N:N43	1.56	No	No	0	5	5
1286	Q:Q:A40	Q:Q:N43	1.56	No	No	0	5	5
1287	U:U:A40	U:U:N43	1.56	No	No	0	5	5
1288	L:L:A40	L:L:N43	1.56	No	No	0	5	5
1289	S:S:I60	S:S:S81	1.55	Yes	Yes	0	7	9
1290	S:S:I213	S:S:S217	1.55	No	No	0	3	3
1291	R:R:I213	R:R:S217	1.55	No	No	0	3	3
1292	C:C:I60	C:C:S81	1.55	No	Yes	0	7	9
1293	C:C:I213	C:C:S217	1.55	No	No	0	3	3
1294	P:P:I213	P:P:S217	1.55	No	No	0	3	3
1295	S:S:I53	S:S:V54	1.54	No	No	0	5	4
1296	R:R:I60	R:R:V82	1.54	No	No	0	7	5
1297	C:C:I270	R:R:V99	1.54	No	No	0	5	4
1298	R:R:A180	R:R:D182	1.54	No	No	0	1	6
1299	C:C:I53	C:C:V54	1.54	No	No	0	5	4
1300	C:C:V62	P:P:I223	1.54	No	No	0	7	4
1301	P:P:I53	P:P:V54	1.54	No	No	0	5	4
1302	S:S:C274	S:S:E26	1.52	No	No	0	5	2
1303	R:R:K68	R:R:V62	1.52	No	No	0	6	7
1304	C:C:I39	P:P:T279	1.52	No	No	0	5	2
1305	P:P:C274	P:P:E26	1.52	No	No	0	5	2
1306	P:P:C274	P:P:E275	1.52	No	No	0	5	3
1307	S:S:F249	S:S:G212	1.51	No	No	0	4	6
1308	R:R:F104	R:R:G105	1.51	Yes	No	0	7	8
1309	R:R:F249	R:R:G212	1.51	No	No	0	4	6
1310	C:C:F249	C:C:G212	1.51	No	No	0	4	6
1311	P:P:F249	P:P:G212	1.51	No	No	0	4	6
1312	Y:Y:L26	Y:Y:S27	1.5	No	No	0	9	6
1313	N:N:L26	N:N:S27	1.5	No	No	0	9	6
1314	S:S:N37	S:S:S285	1.49	Yes	No	0	3	5
1315	M:M:N54	S:S:S178	1.49	No	Yes	0	8	1
1316	S:S:L194	S:S:V198	1.49	No	No	0	2	3
1317	R:R:L165	R:R:V118	1.49	No	No	0	3	5
1318	R:R:L150	R:R:V155	1.49	No	No	0	4	2
1319	M:M:L26	M:M:V24	1.49	No	Yes	0	9	7
1320	C:C:L165	C:C:V118	1.49	No	No	0	3	5
1321	C:C:L194	C:C:V198	1.49	No	No	0	2	3
1322	P:P:L165	P:P:V118	1.49	No	No	0	3	5
1323	P:P:L150	P:P:V155	1.49	No	No	0	4	2
1324	P:P:L194	P:P:V198	1.49	No	No	0	2	3
1325	S:S:N106	S:S:V177	1.48	No	No	0	3	4
1326	C:C:N106	C:C:V177	1.48	No	No	0	3	4
1327	P:P:N106	P:P:V177	1.48	No	No	0	3	4
1328	S:S:I209	S:S:I213	1.47	No	No	0	4	3
1329	R:R:I209	R:R:I213	1.47	No	No	0	4	3
1330	C:C:I209	C:C:I213	1.47	No	No	0	4	3
1331	P:P:I209	P:P:I213	1.47	No	No	0	4	3
1332	L:L:I59	L:L:I72	1.47	No	No	0	9	6
1333	S:S:D193	S:S:V196	1.46	No	No	0	1	4
1334	R:R:D193	R:R:V196	1.46	No	No	0	1	4
1335	C:C:D193	C:C:V196	1.46	No	No	0	1	4
1336	L:L:T52	R:R:D181	1.45	No	No	0	8	2
1337	C:C:I243	C:C:K239	1.45	No	No	0	5	6
1338	P:P:I243	P:P:K239	1.45	No	No	0	5	6
1339	S:S:P147	S:S:R146	1.44	No	No	0	4	5
1340	P:P:Q66	S:S:S224	1.44	No	No	0	4	4
1341	R:R:P147	R:R:R146	1.44	No	No	0	4	5
1342	J:J:K48	M:M:K48	1.44	No	No	0	7	7
1343	q:q:K45	q:q:K64	1.44	No	No	0	7	8
1344	Q:Q:K48	q:q:K48	1.44	No	No	0	7	7
1345	C:C:Q66	P:P:S224	1.44	No	No	0	4	4
1346	C:C:P147	C:C:R146	1.44	No	No	0	4	5
1347	P:P:P147	P:P:R146	1.44	No	No	0	4	5
1348	Y:Y:K45	Y:Y:K64	1.44	No	No	0	7	8
1349	U:U:K48	Y:Y:K48	1.44	No	No	0	7	7
1350	J:J:K45	J:J:K64	1.44	No	No	0	7	8
1351	N:N:K45	N:N:K64	1.44	No	No	0	7	8
1352	L:L:K48	N:N:K48	1.44	No	No	0	7	7
1353	S:S:I60	S:S:L78	1.43	Yes	No	0	7	5
1354	S:S:I162	S:S:L166	1.43	No	No	0	4	4
1355	R:R:I115	R:R:L86	1.43	No	No	0	5	7
1356	R:R:I162	R:R:L166	1.43	No	No	0	4	4
1357	R:R:I286	R:R:L290	1.43	No	No	0	6	7
1358	M:M:I79	M:M:L76	1.43	No	No	0	8	6
1359	q:q:I79	q:q:L76	1.43	No	No	0	8	6
1360	C:C:I60	C:C:L78	1.43	No	No	0	7	5
1361	C:C:I115	C:C:L86	1.43	No	No	0	5	7
1362	C:C:I130	C:C:L244	1.43	No	No	0	8	7
1363	C:C:I162	C:C:L166	1.43	No	No	0	4	4
1364	P:P:I60	P:P:L78	1.43	No	No	0	7	5
1365	P:P:I115	P:P:L86	1.43	No	No	0	5	7
1366	P:P:I162	P:P:L166	1.43	No	No	0	4	4
1367	Y:Y:I79	Y:Y:L76	1.43	No	No	0	8	6
1368	J:J:I79	J:J:L76	1.43	No	No	0	8	6
1369	N:N:I79	N:N:L76	1.43	No	No	0	8	6
1370	Q:Q:I79	Q:Q:L76	1.43	No	No	0	8	6
1371	U:U:I79	U:U:L76	1.43	No	No	0	8	6
1372	L:L:I79	L:L:L76	1.43	No	No	0	8	6
1373	S:S:G105	S:S:W102	1.41	No	Yes	0	8	9
1374	P:P:G105	P:P:W102	1.41	No	Yes	0	8	9
1375	S:S:C251	S:S:F293	1.4	No	Yes	0	8	5
1376	R:R:C251	R:R:F293	1.4	No	No	0	8	5
1377	q:q:C71	q:q:F34	1.4	No	No	0	9	6
1378	C:C:C251	C:C:F293	1.4	No	Yes	0	8	5
1379	P:P:C251	P:P:F293	1.4	No	Yes	0	8	5
1380	Y:Y:C71	Y:Y:F34	1.4	No	No	0	9	6
1381	J:J:C71	J:J:F34	1.4	No	No	0	9	6
1382	L:L:K64	L:L:N43	1.4	No	No	0	8	5
1383	L:L:R29	R:R:C28	1.39	Yes	No	0	9	9
1384	S:S:A237	S:S:R134	1.38	No	Yes	0	7	9
1385	R:R:L226	R:R:L238	1.38	No	No	0	8	5
1386	C:C:A237	C:C:R134	1.38	No	Yes	0	7	9
1387	C:C:L226	C:C:L238	1.38	No	No	0	8	5
1388	P:P:L132	P:P:L136	1.38	No	No	0	6	5
1389	P:P:L132	P:P:L151	1.38	No	No	0	6	4
1390	P:P:A237	P:P:R134	1.38	No	Yes	0	7	9
1391	P:P:L226	P:P:L238	1.38	No	No	0	8	5
1392	C:C:I270	C:C:Q272	1.37	No	No	0	5	2
1393	q:q:N43	q:q:N65	1.36	No	No	0	5	4
1394	C:C:K271	C:C:Q272	1.36	No	No	0	3	2
1395	Y:Y:N43	Y:Y:N65	1.36	No	No	0	5	4
1396	J:J:N43	J:J:N65	1.36	No	No	0	5	4
1397	J:J:N66	L:L:N66	1.36	No	No	0	5	5
1398	N:N:N43	N:N:N65	1.36	No	No	0	5	4
1399	L:L:D73	L:L:L76	1.36	No	No	0	8	6
1400	M:M:E36	S:S:K25	1.35	No	Yes	0	6	4
1401	C:C:K25	Q:Q:E36	1.35	Yes	No	0	4	6
1402	C:C:E32	C:C:K38	1.35	No	No	0	4	4
1403	P:P:K25	U:U:E36	1.35	No	No	0	4	6
1404	M:M:L50	M:M:Q58	1.33	No	No	0	5	9
1405	q:q:L50	q:q:Q58	1.33	No	No	0	5	9
1406	P:P:L266	P:P:Q200	1.33	No	Yes	0	3	5
1407	Y:Y:L50	Y:Y:Q58	1.33	No	No	0	5	9
1408	J:J:L50	J:J:Q58	1.33	No	No	0	5	9
1409	N:N:L50	N:N:Q58	1.33	No	No	0	5	9
1410	Q:Q:L50	Q:Q:Q58	1.33	No	No	0	5	9
1411	U:U:L50	U:U:Q58	1.33	No	No	0	5	9
1412	L:L:L50	L:L:Q58	1.33	No	No	0	5	9
1413	S:S:E31	S:S:N33	1.31	No	No	0	5	6
1414	S:S:E277	S:S:N278	1.31	No	No	0	2	3
1415	R:R:F199	R:R:V198	1.31	Yes	No	0	5	3
1416	J:J:H46	M:M:L50	1.29	No	No	0	8	5
1417	Q:Q:L50	q:q:H46	1.29	No	No	0	5	8
1418	U:U:L50	Y:Y:H46	1.29	No	No	0	5	8
1419	L:L:L50	N:N:H46	1.29	No	No	0	5	8
1420	S:S:V177	S:S:Y184	1.26	No	No	0	4	5
1421	C:C:V177	C:C:Y184	1.26	No	No	0	4	5
1422	P:P:V177	P:P:Y184	1.26	No	No	0	4	5
1423	R:R:I138	R:R:R235	1.25	No	No	0	8	5
1424	S:S:K239	S:S:R235	1.24	No	No	0	6	5
1425	q:q:K45	q:q:R62	1.24	No	No	0	7	6
1426	C:C:K239	C:C:R235	1.24	No	No	0	6	5
1427	P:P:K149	P:P:R146	1.24	No	No	0	6	5
1428	P:P:K239	P:P:R235	1.24	No	No	0	6	5
1429	Y:Y:K45	Y:Y:R62	1.24	No	No	0	7	6
1430	J:J:K45	J:J:R62	1.24	No	No	0	7	6
1431	N:N:K45	N:N:R62	1.24	No	No	0	7	6
1432	S:S:L301	S:S:R77	1.21	No	No	0	7	8
1433	S:S:L226	S:S:R235	1.21	No	No	0	8	5
1434	C:C:L301	C:C:R77	1.21	No	No	0	7	8
1435	C:C:L226	C:C:R235	1.21	No	No	0	8	5
1436	C:C:L266	Q:Q:R33	1.21	No	No	0	3	9
1437	P:P:L301	P:P:R77	1.21	No	No	0	7	8
1438	P:P:L226	P:P:R235	1.21	No	No	0	8	5
1439	q:q:D73	q:q:F35	1.19	No	No	0	8	6
1440	Y:Y:D73	Y:Y:F35	1.19	No	No	0	8	6
1441	J:J:D73	J:J:F35	1.19	No	No	0	8	6
1442	N:N:D73	N:N:F35	1.19	No	No	0	8	6
1443	Q:Q:D73	Q:Q:F35	1.19	No	No	0	8	6
1444	U:U:D73	U:U:F35	1.19	No	No	0	8	6
1445	L:L:D73	L:L:F35	1.19	No	No	0	8	6
1446	S:S:L61	S:S:Y65	1.17	No	No	0	4	5
1447	C:C:L61	C:C:Y65	1.17	No	No	0	4	5
1448	P:P:L61	P:P:Y65	1.17	No	No	0	4	5
1449	q:q:N54	q:q:Y28	1.16	No	No	0	8	8
1450	Y:Y:N54	Y:Y:Y28	1.16	No	No	0	8	8
1451	J:J:N54	J:J:Y28	1.16	No	No	0	8	8
1452	N:N:N54	N:N:Y28	1.16	No	No	0	8	8
1453	S:S:D182	S:S:Y184	1.15	No	No	0	6	5
1454	M:M:R41	M:M:W78	1	No	No	0	6	8
1455	q:q:R41	q:q:W78	1	No	No	0	6	8
1456	Y:Y:R41	Y:Y:W78	1	No	No	0	6	8
1457	J:J:R41	J:J:W78	1	No	No	0	6	8
1458	N:N:R41	N:N:W78	1	No	No	0	6	8
1459	Q:Q:R41	Q:Q:W78	1	No	No	0	6	8
1460	U:U:R41	U:U:W78	1	No	No	0	6	8
1461	L:L:R41	L:L:W78	1	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	S:S:K25	3.105	4	9	4
2	S:S:N37	2.8225	4	0	3
3	S:S:Y45	4.555	6	0	7
4	S:S:N56	5.7025	4	0	9
5	S:S:I60	2.5825	4	0	7
6	S:S:Y76	5.192	5	0	7
7	S:S:S81	5.015	4	0	9
8	S:S:F87	9.1425	4	3	7
9	S:S:L91	3.71	4	0	8
10	S:S:W94	7.3225	4	3	7
11	S:S:W102	8.66	6	3	9
12	S:S:V112	5.0225	4	0	5
13	S:S:H113	4.95833	6	3	6
14	S:S:Y116	6.2	4	3	6
15	S:S:L120	4.73	4	3	7
16	S:S:S122	4.1325	4	19	7
17	S:S:S131	6.1825	4	16	9
18	S:S:R134	3	4	0	9
19	S:S:Y135	4.2625	4	20	8
20	S:S:H140	4.92	4	20	6
21	S:S:V160	4.38	4	19	7
22	S:S:W161	4.795	4	19	9
23	S:S:P170	4.4575	4	0	8
24	S:S:F174	5.656	5	10	4
25	S:S:S178	2.565	4	0	1
26	S:S:R188	9.385	4	0	5
27	S:S:Y190	9.10333	6	10	4
28	S:S:W195	5.9625	4	10	5
29	S:S:H203	8.56	5	3	4
30	S:S:Y219	6.235	4	16	8
31	S:S:I245	3.845	4	16	7
32	S:S:F248	6.8	6	3	9
33	S:S:W252	9.632	5	3	9
34	S:S:Y255	6.47833	6	3	7
35	S:S:Y256	6.166	5	3	8
36	S:S:I259	5.336	5	3	5
37	S:S:I261	4.655	4	11	5
38	S:S:K271	3.9475	4	9	3
39	S:S:F276	4.376	5	0	1
40	S:S:V280	3.94	4	11	5
41	S:S:W283	7.378	5	0	6
42	S:S:F293	5.4975	4	0	5
43	S:S:H294	8.7475	4	3	9
44	S:S:P299	3.935	4	0	9
45	R:R:N35	5.735	4	0	3
46	R:R:Y45	4.186	5	1	7
47	R:R:I48	3.52	4	0	7
48	R:R:M63	5.025	4	23	6
49	R:R:Y76	4.72	6	0	7
50	R:R:H79	5.135	4	12	9
51	R:R:F87	8.4625	4	1	7
52	R:R:L91	3.4175	4	0	8
53	R:R:W94	7.4125	4	0	7
54	R:R:W102	8.78833	6	6	9
55	R:R:F104	7.938	5	6	7
56	R:R:V112	5.3275	4	6	5
57	R:R:H113	4.296	5	6	6
58	R:R:Y116	5.73	4	1	6
59	R:R:T117	5.565	4	0	5
60	R:R:Y121	5.9275	4	1	7
61	R:R:S122	4.87	4	12	7
62	R:R:F129	3.635	4	0	5
63	R:R:R134	3.9075	4	0	9
64	R:R:Y135	4.975	4	0	8
65	R:R:L136	3.2325	4	25	5
66	R:R:R148	6.502	5	25	6
67	R:R:V160	4.29	5	12	7
68	R:R:W161	4.29333	6	12	9
69	R:R:P170	4.4575	4	0	8
70	R:R:F174	6.8625	4	7	4
71	R:R:R188	7.13	5	7	5
72	R:R:Y190	9.425	6	7	4
73	R:R:W195	5.19	5	7	5
74	R:R:F199	6.8575	4	7	5
75	R:R:H203	7.91	5	1	4
76	R:R:Y219	5.0025	4	0	8
77	R:R:T241	4.3975	4	0	7
78	R:R:F248	6.19333	6	1	9
79	R:R:W252	8.36	5	1	9
80	R:R:Y255	6.06667	6	1	7
81	R:R:Y256	6.618	5	1	8
82	R:R:I259	5.402	5	1	5
83	R:R:D262	3.814	5	1	5
84	R:R:F276	5.545	4	0	1
85	R:R:H281	4.335	4	0	4
86	R:R:W283	7.858	5	0	6
87	R:R:N298	7.42	4	0	9
88	M:M:K22	8.665	4	3	9
89	M:M:P23	7.0475	4	3	9
90	M:M:V24	3.7925	4	3	7
91	M:M:R29	4.2175	4	0	9
92	C:C:K25	3.465	4	0	4
93	C:C:P27	3.8375	4	0	5
94	C:C:N37	4.7075	4	0	3
95	C:C:Y45	4.698	5	0	7
96	C:C:Y76	5.5425	4	0	7
97	C:C:S81	5.015	4	0	9
98	C:C:F87	9.1425	4	30	7
99	C:C:L91	3.4175	4	0	8
100	C:C:F93	5.595	4	2	6
101	C:C:W94	6.7675	4	0	7
102	C:C:W102	8.29167	6	2	9
103	C:C:V112	6.12	4	2	5
104	C:C:H113	4.418	5	2	6
105	C:C:S122	3.825	4	32	7
106	C:C:R134	2.93833	6	13	9
107	C:C:Y135	5.185	4	33	8
108	C:C:H140	5.1925	4	33	6
109	C:C:R148	6.1625	4	13	6
110	C:C:V160	4.7775	4	32	7
111	C:C:W161	5.0175	4	32	9
112	C:C:T168	3.49	4	2	6
113	C:C:P170	4.4575	4	0	8
114	C:C:D171	8.1475	4	2	4
115	C:C:F174	6.15	5	14	4
116	C:C:R188	8.086	5	0	5
117	C:C:F189	5.4	4	0	3
118	C:C:Y190	9.44667	6	14	4
119	C:C:W195	5.68	4	14	5
120	C:C:H203	8.864	5	2	4
121	C:C:F248	6.8	6	2	9
122	C:C:W252	9.194	5	2	9
123	C:C:Y255	5.94714	7	2	7
124	C:C:Y256	5.968	5	2	8
125	C:C:I259	5.348	5	2	5
126	C:C:F276	4.114	5	0	1
127	C:C:H281	8.0575	4	0	4
128	C:C:W283	7.388	5	0	6
129	C:C:F292	8.7825	4	30	7
130	C:C:F293	5.4975	4	0	5
131	C:C:H294	8.4825	4	2	9
132	C:C:N298	5.305	4	0	9
133	P:P:P27	3.8375	4	0	5
134	P:P:E31	5.91	4	34	5
135	P:P:N35	5.37	4	0	3
136	P:P:N37	3.2575	4	0	3
137	P:P:Y45	4.36	6	0	7
138	P:P:N56	5.7025	4	0	9
139	P:P:Y76	4.68	5	8	7
140	P:P:F87	9.1425	4	5	7
141	P:P:L91	3.4175	4	0	8
142	P:P:W94	7.3225	4	5	7
143	P:P:W102	8.64167	6	5	9
144	P:P:V112	5.815	4	0	5
145	P:P:H113	4.27667	6	5	6
146	P:P:S122	4.2525	4	8	7
147	P:P:I126	5.0175	4	8	7
148	P:P:R134	2.886	5	0	9
149	P:P:Y135	4.9125	4	36	8
150	P:P:H140	5.1875	4	36	6
151	P:P:V160	4.7775	4	8	7
152	P:P:W161	5.0175	4	8	9
153	P:P:P170	4.4575	4	0	8
154	P:P:F174	5.944	5	15	4
155	P:P:I185	3.21	4	37	3
156	P:P:R188	8.1625	4	0	5
157	P:P:F189	5.575	4	37	3
158	P:P:Y190	7.34286	7	15	4
159	P:P:W195	6.2025	4	15	5
160	P:P:Q200	4.1225	4	0	5
161	P:P:H203	8.036	5	4	4
162	P:P:F248	6.8	6	4	9
163	P:P:W252	9.386	5	4	9
164	P:P:Y255	5.90429	7	4	7
165	P:P:Y256	5.75	5	4	8
166	P:P:I259	5.9025	4	4	5
167	P:P:I261	4.27	4	29	5
168	P:P:F276	4.2625	4	0	1
169	P:P:E277	7.1475	4	0	2
170	P:P:W283	7.378	5	0	6
171	P:P:F292	8.4925	4	5	7
172	P:P:F293	5.4975	4	0	5
173	P:P:H294	8.4825	4	4	9
174	P:P:N298	4.6175	4	0	9
175	P:P:P299	3.935	4	0	9
176	Q:Q:K22	7.63	5	0	9
177	Q:Q:P23	6.9	5	2	9
178	Q:Q:V24	4.9225	4	2	7
179	U:U:K22	8.945	4	5	9
180	U:U:P23	7.025	4	4	9
181	L:L:L26	4.51	4	1	9
182	L:L:R29	5.1825	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:E26	S:S:P27	13.1518	7.86	No	No	0	2	5
2	M:M:P31	S:S:P27	11.9042	1.95	No	No	0	7	5
3	R:R:I259	R:R:I284	12.7741	4.42	Yes	No	1	5	4
4	R:R:I259	R:R:Y256	11.3943	3.63	Yes	Yes	1	5	8
5	R:R:L208	R:R:Y256	75.3324	12.89	No	Yes	0	8	8
6	R:R:L208	R:R:L253	75.9359	2.77	No	No	0	8	5
7	R:R:L253	S:S:L50	76.137	2.77	No	No	0	5	5
8	S:S:F49	S:S:L50	76.2392	3.65	No	No	0	6	5
9	S:S:F49	S:S:L91	76.4496	3.65	No	Yes	0	6	8
10	S:S:L91	S:S:Y45	11.1492	4.69	Yes	Yes	0	8	7
11	S:S:W94	S:S:Y45	10.3939	2.89	Yes	Yes	0	7	7
12	M:M:K22	S:S:E288	16.0704	8.1	Yes	No	0	9	5
13	S:S:E288	S:S:Y255	16.1964	5.61	No	Yes	0	5	7
14	S:S:I259	S:S:Y255	19.7464	9.67	Yes	Yes	3	5	7
15	S:S:I259	S:S:I284	23.0574	4.42	Yes	No	0	5	4
16	S:S:I284	S:S:V280	21.915	3.07	No	Yes	0	4	5
17	S:S:F276	S:S:V280	24.9533	6.55	Yes	Yes	0	1	5
18	P:P:N35	S:S:F276	19.9956	4.83	Yes	Yes	0	3	1
19	P:P:N35	S:S:E275	15.6441	2.63	Yes	No	0	3	3
20	S:S:C274	S:S:E275	15.0214	3.04	No	No	0	5	3
21	S:S:C274	S:S:E26	14.3985	1.52	No	No	0	5	2
22	S:S:F87	S:S:L91	69.4858	3.65	Yes	Yes	0	7	8
23	S:S:F87	S:S:Y116	42.3175	8.25	Yes	Yes	3	7	6
24	S:S:L120	S:S:Y116	39.4587	3.52	Yes	Yes	3	7	6
25	S:S:H203	S:S:L120	32.3303	6.43	Yes	Yes	3	4	7
26	S:S:W252	S:S:Y255	69.3384	5.79	Yes	Yes	3	9	7
27	S:S:F87	S:S:N119	31.6596	9.67	Yes	No	0	7	8
28	S:S:H294	S:S:N119	31.7066	3.83	Yes	No	0	9	8
29	S:S:H294	S:S:W252	58.776	15.87	Yes	Yes	3	9	9
30	S:S:H203	S:S:Y256	34.6952	7.62	Yes	Yes	3	4	8
31	S:S:C295	S:S:V88	40.2645	3.42	No	No	0	9	6
32	S:S:C295	S:S:H294	80.4931	7.37	No	Yes	0	9	9
33	S:S:N56	S:S:P299	40.0098	3.26	Yes	Yes	0	9	9
34	S:S:D84	S:S:N56	39.6931	12.12	No	Yes	0	9	9
35	S:S:C295	S:S:D84	39.9697	7.78	No	No	0	9	9
36	S:S:N56	S:S:V88	39.7113	2.96	Yes	No	0	9	6
37	S:S:N56	S:S:S81	38.835	4.47	Yes	Yes	0	9	9
38	R:R:I245	R:R:L127	31.2047	7.14	No	No	0	7	8
39	R:R:F248	R:R:L127	32.2917	6.09	Yes	No	0	9	8
40	R:R:F248	R:R:W252	23.279	12.03	Yes	Yes	1	9	9
41	R:R:W252	R:R:Y255	23.2675	5.79	Yes	Yes	1	9	7
42	R:R:Y255	R:R:Y256	49.114	4.96	Yes	Yes	1	7	8
43	R:R:I245	R:R:Y219	26.0728	3.63	No	Yes	0	7	8
44	S:S:N298	S:S:S81	34.7656	5.96	No	Yes	0	9	9
45	S:S:N298	S:S:R77	68.3631	3.62	No	No	0	9	8
46	S:S:R77	S:S:Y302	60.2684	30.87	No	No	0	8	9
47	S:S:N298	S:S:P299	34.7821	4.89	No	Yes	0	9	9
48	S:S:D74	S:S:Y302	49.6382	6.9	No	No	18	8	9
49	S:S:D74	S:S:S71	48.5038	5.89	No	No	0	8	7
50	S:S:S71	S:S:T73	47.326	3.2	No	No	0	7	7
51	S:S:R134	S:S:T73	46.1478	3.88	Yes	No	0	9	7
52	S:S:A137	S:S:R134	41.4327	4.15	No	Yes	0	8	9
53	S:S:A137	S:S:R148	40.2533	6.91	No	No	0	8	6
54	S:S:F129	S:S:Y76	11.87	4.13	No	Yes	0	5	7
55	S:S:D133	S:S:Y76	28.4206	9.2	No	Yes	0	8	7
56	S:S:D133	S:S:R148	29.6016	8.34	No	No	0	8	6
57	S:S:I130	S:S:Y76	14.241	4.84	No	Yes	0	8	7
58	S:S:I126	S:S:V160	10.6842	6.14	No	Yes	0	7	7
59	S:S:I126	S:S:I130	13.0556	2.94	No	No	0	7	8
60	S:S:F248	S:S:W252	10.0664	13.03	Yes	Yes	3	9	9
61	S:S:F248	S:S:L127	10.4999	6.09	Yes	No	0	9	8
62	S:S:L208	S:S:Y256	99.391	11.72	No	Yes	0	8	8
63	P:P:N56	P:P:P299	37.4565	3.26	Yes	Yes	0	9	9
64	P:P:D84	P:P:N56	36.0362	12.12	No	Yes	0	9	9
65	P:P:C295	P:P:D84	36.2502	9.34	No	No	0	9	9
66	P:P:C295	P:P:H294	72.9284	7.37	No	Yes	0	9	9
67	P:P:H294	P:P:N119	44.492	3.83	Yes	No	0	9	8
68	P:P:F87	P:P:N119	44.4722	9.67	Yes	No	0	7	8
69	P:P:F87	P:P:L91	74.225	3.65	Yes	Yes	0	7	8
70	P:P:I48	P:P:L91	15.7027	2.85	No	Yes	0	7	8
71	P:P:I44	P:P:I48	12.3375	2.94	No	No	0	5	7
72	P:P:F40	P:P:I44	12.0546	8.79	No	No	0	5	5
73	P:P:F36	P:P:F40	12.1956	7.5	No	No	0	4	5
74	P:P:F36	S:S:W283	12.358	3.01	No	Yes	0	4	6
75	P:P:I39	S:S:W283	13.6623	14.09	No	Yes	0	5	6
76	P:P:I39	S:S:V280	13.1686	3.07	No	Yes	11	5	5
77	P:P:N56	P:P:V88	36.0571	2.96	Yes	No	0	9	6
78	P:P:C295	P:P:V88	36.4849	3.42	No	No	0	9	6
79	S:S:L208	S:S:L253	99.4907	2.77	No	No	0	8	5
80	L:L:L26	R:R:D262	10.789	2.71	Yes	Yes	1	9	5
81	C:C:W283	R:R:I39	10.644	12.92	Yes	No	0	6	5
82	C:C:W283	R:R:F36	45.2837	3.01	Yes	No	0	6	4
83	R:R:F36	R:R:F40	45.2367	9.65	No	No	0	4	5
84	R:R:F40	R:R:I44	45.1974	11.3	No	No	0	5	5
85	R:R:I44	R:R:I48	45.1634	2.94	No	Yes	0	5	7
86	R:R:I48	R:R:L91	43.6945	2.85	Yes	Yes	0	7	8
87	R:R:F87	R:R:L91	42.68	3.65	Yes	Yes	0	7	8
88	R:R:F87	R:R:Y116	31.1855	6.19	Yes	Yes	1	7	6
89	R:R:E288	R:R:Y116	25.5857	3.37	No	Yes	1	5	6
90	R:R:E288	R:R:Y255	33.0543	5.61	No	Yes	1	5	7
91	C:C:T287	C:C:W283	47.6907	10.92	No	Yes	0	6	6
92	C:C:T287	C:C:Y255	47.8004	3.75	No	Yes	0	6	7
93	C:C:E288	C:C:Y255	29.0836	5.61	No	Yes	0	5	7
94	C:C:E288	C:C:F292	27.841	4.66	No	Yes	0	5	7
95	C:C:F292	C:C:Y45	14.6083	7.22	Yes	Yes	0	7	7
96	C:C:L91	C:C:Y45	45.4828	3.52	Yes	Yes	0	8	7
97	C:C:F49	C:C:L91	89.5676	3.65	No	Yes	0	6	8
98	C:C:F49	C:C:L50	89.6575	3.65	No	No	0	6	5
99	C:C:L50	P:P:L253	89.7071	2.77	No	No	0	5	5
100	P:P:L208	P:P:L253	89.8106	2.77	No	No	0	8	5
101	P:P:L208	P:P:Y256	89.8651	11.72	No	Yes	0	8	8
102	P:P:Y255	P:P:Y256	81.7884	3.97	Yes	Yes	4	7	8
103	P:P:E288	P:P:Y255	68.9793	5.61	No	Yes	0	5	7
104	P:P:E288	P:P:F292	64.6673	3.5	No	Yes	0	5	7
105	P:P:F292	P:P:Y45	33.8138	7.22	Yes	Yes	0	7	7
106	P:P:L91	P:P:Y45	41.3812	3.52	Yes	Yes	0	8	7
107	C:C:F292	C:C:F87	14.1719	15	Yes	Yes	30	7	7
108	C:C:F87	C:C:L91	51.9312	3.65	Yes	Yes	0	7	8
109	P:P:F292	P:P:F87	33.0597	15	Yes	Yes	5	7	7
110	R:R:C295	R:R:I48	11.4564	3.27	No	Yes	0	9	7
111	L:L:K22	R:R:W94	13.3874	12.76	No	Yes	0	9	7
112	R:R:D84	R:R:N56	10.0825	12.12	No	No	0	9	9
113	R:R:C295	R:R:D84	10.4263	7.78	No	No	0	9	9
114	C:C:H294	C:C:N119	23.5332	3.83	Yes	No	0	9	8
115	C:C:F87	C:C:N119	23.6706	9.67	Yes	No	0	7	8
116	R:R:I130	R:R:Y76	15.616	4.84	No	Yes	0	8	7
117	R:R:I130	R:R:T241	15.8978	3.04	No	Yes	0	8	7
118	R:R:T241	R:R:Y219	20.6954	6.24	Yes	Yes	0	7	8
119	R:R:H294	R:R:N119	11.385	5.1	No	No	0	9	8
120	R:R:D171	R:R:T117	13.9892	10.12	No	Yes	0	4	5
121	R:R:H203	R:R:Y256	15.5324	8.71	Yes	Yes	1	4	8
122	R:R:D171	R:R:R188	14.263	9.53	No	Yes	0	4	5
123	C:C:W94	Q:Q:K22	18.1979	12.76	Yes	Yes	0	7	9
124	C:C:W94	C:C:Y45	30.3137	2.89	Yes	Yes	0	7	7
125	C:C:Y116	Q:Q:K22	15.0509	9.55	No	Yes	0	6	9
126	C:C:F87	C:C:Y116	15.1268	8.25	Yes	No	30	7	6
127	C:C:C295	C:C:H294	24.1166	7.37	No	Yes	0	9	9
128	C:C:D84	C:C:L80	20.8831	4.07	No	No	0	9	9
129	C:C:C295	C:C:D84	23.2535	9.34	No	No	0	9	9
130	C:C:I126	C:C:L80	12.9377	4.28	No	No	0	7	9
131	C:C:H113	C:C:W94	12.9323	5.29	Yes	Yes	0	6	7
132	C:C:D187	Q:Q:S25	11.1643	7.36	No	No	0	3	9
133	C:C:R188	Q:Q:S25	22.3241	2.64	Yes	No	0	5	9
134	C:C:D171	C:C:R188	10.241	13.1	Yes	Yes	0	4	5
135	C:C:D171	C:C:H113	11.5834	5.04	Yes	Yes	2	4	6
136	Q:Q:S25	Q:Q:Y28	10.4665	5.09	No	No	0	9	8
137	C:C:R188	Q:Q:P23	26.1996	4.32	Yes	Yes	0	5	9
138	Q:Q:K22	Q:Q:P23	22.6217	3.35	Yes	Yes	0	9	9
139	P:P:D262	P:P:E277	10.1401	3.9	No	Yes	0	5	2
140	P:P:D262	P:P:Q200	10.5104	6.53	No	Yes	0	5	5
141	P:P:Q200	U:U:V24	13.4818	4.3	Yes	No	0	5	7
142	P:P:Y255	U:U:V24	13.8537	5.05	Yes	No	0	7	7
143	P:P:F49	P:P:L50	99.7932	3.65	No	No	0	6	5
144	P:P:L50	S:S:L253	99.6898	2.77	No	No	0	5	5
145	P:P:N56	P:P:S81	34.1905	4.47	Yes	No	0	9	9
146	P:P:I126	P:P:V160	12.2467	9.22	Yes	Yes	8	7	7
147	P:P:I126	P:P:L80	35.9417	4.28	Yes	No	0	7	9
148	P:P:L80	P:P:N298	36.869	5.49	No	Yes	0	9	9
149	P:P:N298	P:P:S81	33.2797	4.47	Yes	No	0	9	9
150	P:P:N298	P:P:P299	33.3585	4.89	Yes	Yes	0	9	9
151	P:P:R77	P:P:Y302	14.0393	30.87	No	No	0	8	9
152	P:P:N298	P:P:R77	28.9888	3.62	Yes	No	0	9	8
153	P:P:D133	P:P:R148	10.4193	11.91	No	No	0	8	6
154	P:P:D133	P:P:Y76	11.353	8.05	No	Yes	0	8	7
155	P:P:I126	P:P:Y76	22.0317	3.63	Yes	Yes	8	7	7
156	P:P:H294	P:P:W252	33.3446	14.81	Yes	Yes	4	9	9
157	P:P:K239	P:P:R235	11.21	1.24	No	No	0	6	5
158	P:P:I243	P:P:K239	12.1473	1.45	No	No	0	5	6
159	P:P:I243	P:P:L301	13.0849	4.28	No	No	0	5	7
160	P:P:L301	P:P:R77	14.0255	1.21	No	No	0	7	8
161	P:P:F49	P:P:L91	100	3.65	No	Yes	0	6	8
162	C:C:W252	C:C:Y255	10.361	5.79	Yes	Yes	2	9	7
163	S:S:Y255	S:S:Y256	64.9192	4.96	Yes	Yes	3	7	8
164	R:R:F87	R:R:N119	11.4226	13.29	Yes	No	0	7	8
165	R:R:F248	R:R:H294	10.6352	7.92	Yes	No	1	9	9
166	P:P:W252	P:P:Y255	35.1282	6.75	Yes	Yes	4	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
C:C:K25	C:C:K271	5.75	0	Yes	No	4	3	1	2
C:C:K25	Q:Q:F34	3.72	0	Yes	No	4	6	1	0
C:C:K25	Q:Q:V70	3.04	0	Yes	No	4	9	1	0
C:C:E26	C:C:P27	7.86	0	No	Yes	2	5	2	1
C:C:P27	Q:Q:C71	3.77	0	Yes	No	5	9	1	0
C:C:C28	Q:Q:P31	7.53	0	No	No	9	7	1	0
C:C:R30	Q:Q:R29	22.39	0	No	No	5	9	1	0
C:C:E31	C:C:N278	6.57	0	No	No	5	3	2	1
C:C:W94	C:C:Y45	2.89	0	Yes	Yes	7	7	1	2
C:C:F292	C:C:Y45	7.22	30	Yes	Yes	7	7	2	2
C:C:F87	C:C:Y116	8.25	30	Yes	No	7	6	2	1
C:C:F292	C:C:F87	15	30	Yes	Yes	7	7	2	2
C:C:V112	C:C:W94	6.13	2	Yes	Yes	5	7	2	1
C:C:H113	C:C:W94	5.29	2	Yes	Yes	6	7	2	1
C:C:W94	Q:Q:K22	12.76	0	Yes	Yes	7	9	1	0
C:C:D171	C:C:H113	5.04	2	Yes	Yes	4	6	2	2
C:C:F292	C:C:Y116	8.25	30	Yes	No	7	6	2	1
C:C:Y116	Q:Q:K22	9.55	30	No	Yes	6	9	1	0
C:C:T117	C:C:T168	3.14	2	No	Yes	5	6	1	2
C:C:D171	C:C:T117	11.56	2	Yes	No	4	5	2	1
C:C:T117	Q:Q:P23	5.25	2	No	Yes	5	9	1	0
C:C:H203	C:C:L120	6.43	2	Yes	No	4	7	1	1
C:C:L120	C:C:W252	4.56	2	No	Yes	7	9	1	2
C:C:L120	Q:Q:P23	3.28	2	No	Yes	7	9	1	0
C:C:H203	C:C:Y121	5.44	2	Yes	No	4	7	1	2
C:C:D171	C:C:T168	2.89	2	Yes	Yes	4	6	2	2
C:C:P170	C:C:R188	2.88	0	Yes	Yes	8	5	2	1
C:C:D171	C:C:R188	13.1	2	Yes	Yes	4	5	2	1
C:C:I185	C:C:S178	3.1	0	No	No	3	1	2	1
C:C:F189	C:C:S178	5.28	0	Yes	No	3	1	1	1
C:C:S178	Q:Q:N54	2.98	0	No	No	1	8	1	0
C:C:D187	C:C:F189	3.58	0	No	Yes	3	3	1	1
C:C:D187	Q:Q:S25	7.36	0	No	No	3	9	1	0
C:C:D187	Q:Q:S27	7.36	0	No	No	3	6	1	0
C:C:R188	C:C:Y190	17.49	0	Yes	Yes	5	4	1	2
C:C:R188	Q:Q:P23	4.32	0	Yes	Yes	5	9	1	0
C:C:F189	Q:Q:Y28	10.32	0	Yes	No	3	8	1	0
C:C:L266	C:C:V197	4.47	0	No	No	3	3	1	2
C:C:D262	C:C:Q200	6.53	0	No	No	5	5	2	1
C:C:Q200	C:C:S263	5.78	0	No	No	5	5	1	2
C:C:Q200	Q:Q:V24	5.73	0	No	Yes	5	7	1	0
C:C:H203	C:C:Y255	6.53	2	Yes	Yes	4	7	1	1
C:C:H203	C:C:Y256	7.62	2	Yes	Yes	4	8	1	2
C:C:H203	Q:Q:P23	18.3	2	Yes	Yes	4	9	1	0
C:C:I204	C:C:I259	5.89	0	No	Yes	5	5	2	1
C:C:W252	C:C:Y255	5.79	2	Yes	Yes	9	7	2	1
C:C:Y255	C:C:Y256	3.97	2	Yes	Yes	7	8	1	2
C:C:I259	C:C:Y255	9.67	2	Yes	Yes	5	7	1	1
C:C:T287	C:C:Y255	3.75	0	No	Yes	6	7	2	1
C:C:E288	C:C:Y255	5.61	0	No	Yes	5	7	1	1
C:C:Y255	Q:Q:V24	6.31	2	Yes	Yes	7	7	1	0
C:C:I259	C:C:Y256	3.63	2	Yes	Yes	5	8	1	2
C:C:I259	C:C:I284	2.94	2	Yes	No	5	4	1	1
C:C:I259	Q:Q:V24	4.61	2	Yes	Yes	5	7	1	0
C:C:D262	C:C:H281	3.78	0	No	Yes	5	4	2	1
C:C:E268	C:C:K271	4.05	0	No	No	2	3	1	2
C:C:E268	Q:Q:R33	11.63	0	No	No	2	9	1	0
C:C:E277	C:C:H281	14.77	0	No	Yes	2	4	2	1
C:C:N278	Q:Q:R29	3.62	0	No	No	3	9	1	0
C:C:H281	Q:Q:L26	10.29	0	Yes	No	4	9	1	0
C:C:H281	Q:Q:R29	3.39	0	Yes	No	4	9	1	0
C:C:I284	Q:Q:L26	2.85	0	No	No	4	9	1	0
C:C:E288	C:C:F292	4.66	0	No	Yes	5	7	1	2
C:C:E288	Q:Q:K22	9.45	0	No	Yes	5	9	1	0
C:C:C28	C:C:R30	2.79	0	No	No	9	5	1	1
C:C:R188	Q:Q:S25	2.64	0	Yes	No	5	9	1	0
C:C:F189	C:C:N176	2.42	0	Yes	No	3	4	1	2
C:C:P27	Q:Q:P31	1.95	0	Yes	No	5	7	1	0
C:C:P27	Q:Q:V60	1.77	0	Yes	No	5	8	1	0
C:C:K25	Q:Q:E36	1.35	0	Yes	No	4	6	1	0
C:C:L266	Q:Q:R33	1.21	0	No	No	3	9	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
P:P:K25	U:U:F34	3.72	0	No	No	4	6	1	0
P:P:K25	U:U:V70	3.04	0	No	No	4	9	1	0
P:P:E26	P:P:P27	7.86	0	No	Yes	2	5	2	1
P:P:P27	U:U:C71	3.77	0	Yes	No	5	9	1	0
P:P:C28	U:U:P31	7.53	0	No	No	9	7	1	0
P:P:H281	P:P:R30	5.64	0	No	No	4	5	1	1
P:P:R30	U:U:R29	3.2	0	No	No	5	9	1	0
P:P:W94	P:P:Y45	2.89	5	Yes	Yes	7	7	1	2
P:P:F292	P:P:Y45	7.22	5	Yes	Yes	7	7	2	2
P:P:F87	P:P:Y116	8.25	5	Yes	No	7	6	2	1
P:P:F292	P:P:F87	15	5	Yes	Yes	7	7	2	2
P:P:V112	P:P:W94	6.13	0	Yes	Yes	5	7	2	1
P:P:H113	P:P:W94	6.35	5	Yes	Yes	6	7	1	1
P:P:W94	U:U:K22	13.92	5	Yes	Yes	7	9	1	0
P:P:C109	P:P:H113	2.95	5	No	Yes	9	6	2	1
P:P:C109	P:P:C186	7.28	5	No	No	9	9	2	2
P:P:D171	P:P:H113	3.78	0	No	Yes	4	6	2	1
P:P:A175	P:P:H113	4.39	0	No	Yes	4	6	2	1
P:P:C186	P:P:H113	2.95	5	No	Yes	9	6	2	1
P:P:H113	U:U:K22	5.24	5	Yes	Yes	6	9	1	0
P:P:F292	P:P:Y116	8.25	5	Yes	No	7	6	2	1
P:P:Y116	U:U:K22	7.17	5	No	Yes	6	9	1	0
P:P:T117	P:P:T168	3.14	0	No	No	5	6	1	2
P:P:D171	P:P:T117	11.56	0	No	No	4	5	2	1
P:P:T117	U:U:P23	5.25	0	No	Yes	5	9	1	0
P:P:H203	P:P:L120	6.43	4	Yes	No	4	7	1	1
P:P:L120	P:P:W252	4.56	4	No	Yes	7	9	1	2
P:P:L120	U:U:P23	3.28	4	No	Yes	7	9	1	0
P:P:H203	P:P:Y121	5.44	4	Yes	No	4	7	1	2
P:P:F174	P:P:P170	2.89	15	Yes	Yes	4	8	2	2
P:P:P170	P:P:R188	2.88	0	Yes	Yes	8	5	2	1
P:P:F199	P:P:P170	8.67	15	No	Yes	5	8	2	2
P:P:D171	P:P:R188	13.1	0	No	Yes	4	5	2	1
P:P:F174	P:P:Y190	6.19	15	Yes	Yes	4	4	2	1
P:P:F174	P:P:P191	4.33	15	Yes	No	4	5	2	2
P:P:F174	P:P:W195	5.01	15	Yes	Yes	4	5	2	2
P:P:I185	P:P:S178	3.1	37	Yes	No	3	1	1	1
P:P:F189	P:P:S178	6.61	37	Yes	No	3	1	1	1
P:P:S178	U:U:N54	2.98	37	No	No	1	8	1	0
P:P:F189	P:P:I185	5.02	37	Yes	Yes	3	3	1	1
P:P:I185	U:U:S27	3.1	37	Yes	No	3	6	1	0
P:P:D187	U:U:S25	8.83	0	No	No	3	9	1	0
P:P:D187	U:U:S27	5.89	0	No	No	3	6	1	0
P:P:R188	P:P:Y190	12.35	0	Yes	Yes	5	4	1	1
P:P:R188	U:U:P23	4.32	0	Yes	Yes	5	9	1	0
P:P:F189	U:U:Y28	8.25	37	Yes	No	3	8	1	0
P:P:P191	P:P:Y190	4.17	15	No	Yes	5	4	2	1
P:P:W195	P:P:Y190	6.75	15	Yes	Yes	5	4	2	1
P:P:V196	P:P:Y190	7.57	0	No	Yes	4	4	2	1
P:P:F199	P:P:Y190	12.38	15	No	Yes	5	4	2	1
P:P:F199	P:P:W195	4.01	15	No	Yes	5	5	2	2
P:P:D262	P:P:Q200	6.53	0	No	Yes	5	5	2	1
P:P:Q200	P:P:S263	4.33	0	Yes	No	5	5	1	2
P:P:Q200	U:U:V24	4.3	0	Yes	No	5	7	1	0
P:P:H203	P:P:Y255	6.53	4	Yes	Yes	4	7	1	1
P:P:H203	P:P:Y256	6.53	4	Yes	Yes	4	8	1	2
P:P:H203	U:U:P23	15.25	4	Yes	Yes	4	9	1	0
P:P:W252	P:P:Y255	6.75	4	Yes	Yes	9	7	2	1
P:P:Y255	P:P:Y256	3.97	4	Yes	Yes	7	8	1	2
P:P:I259	P:P:Y255	9.67	4	Yes	Yes	5	7	2	1
P:P:T287	P:P:Y255	3.75	0	No	Yes	6	7	2	1
P:P:E288	P:P:Y255	5.61	0	No	Yes	5	7	1	1
P:P:Y255	U:U:V24	5.05	4	Yes	No	7	7	1	0
P:P:I259	P:P:Y256	3.63	4	Yes	Yes	5	8	2	2
P:P:D262	P:P:E277	3.9	0	No	Yes	5	2	2	1
P:P:E277	P:P:I265	4.1	0	Yes	No	2	3	1	2
P:P:E268	P:P:K271	4.05	0	No	No	2	3	1	2
P:P:E268	U:U:R33	15.12	0	No	No	2	9	1	0
P:P:E277	P:P:H281	14.77	0	Yes	No	2	4	1	1
P:P:E277	U:U:R29	5.82	0	Yes	No	2	9	1	0
P:P:H281	U:U:L26	6.43	0	No	No	4	9	1	0
P:P:E288	P:P:F292	3.5	0	No	Yes	5	7	1	2
P:P:E288	U:U:K22	9.45	0	No	Yes	5	9	1	0
P:P:C28	P:P:R30	2.79	0	No	No	9	5	1	1
P:P:F189	P:P:N176	2.42	37	Yes	No	3	4	1	2
P:P:Y190	U:U:Y28	1.99	15	Yes	No	4	8	1	0
P:P:P27	U:U:P31	1.95	0	Yes	No	5	7	1	0
P:P:P27	U:U:V60	1.77	0	Yes	No	5	8	1	0
P:P:A180	P:P:I185	1.62	0	No	Yes	1	3	2	1
P:P:D193	U:U:C32	1.56	0	No	No	1	9	1	0
P:P:K25	U:U:E36	1.35	0	No	No	4	6	1	0
P:P:L266	P:P:Q200	1.33	0	No	Yes	3	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:K25	S:S:K271	4.31	9	Yes	Yes	4	3	1	1
M:M:F34	S:S:K25	3.72	9	No	Yes	6	4	0	1
M:M:V70	S:S:K25	3.04	0	No	Yes	9	4	0	1
S:S:E26	S:S:P27	7.86	0	No	No	2	5	2	1
M:M:C71	S:S:P27	3.77	0	No	No	9	5	0	1
S:S:C28	S:S:R30	4.18	0	No	No	9	5	1	1
M:M:P31	S:S:C28	3.77	0	No	No	7	9	0	1
M:M:R29	S:S:R30	3.2	0	Yes	No	9	5	0	1
S:S:W94	S:S:Y45	2.89	3	Yes	Yes	7	7	1	2
S:S:F292	S:S:Y45	7.22	3	No	Yes	7	7	2	2
S:S:F87	S:S:Y116	8.25	3	Yes	Yes	7	6	2	1
S:S:F292	S:S:F87	15	3	No	Yes	7	7	2	2
S:S:V112	S:S:W94	6.13	0	Yes	Yes	5	7	2	1
S:S:H113	S:S:W94	6.35	3	Yes	Yes	6	7	1	1
M:M:K22	S:S:W94	13.92	3	Yes	Yes	9	7	0	1
S:S:C109	S:S:H113	2.95	3	No	Yes	9	6	2	1
S:S:C109	S:S:C186	7.28	3	No	No	9	9	2	2
S:S:D171	S:S:H113	3.78	0	No	Yes	4	6	2	1
S:S:A175	S:S:H113	4.39	0	No	Yes	4	6	2	1
S:S:C186	S:S:H113	4.42	3	No	Yes	9	6	2	1
M:M:K22	S:S:H113	7.86	3	Yes	Yes	9	6	0	1
S:S:L120	S:S:Y116	3.52	3	Yes	Yes	7	6	1	1
S:S:F292	S:S:Y116	8.25	3	No	Yes	7	6	2	1
M:M:K22	S:S:Y116	4.78	3	Yes	Yes	9	6	0	1
S:S:T117	S:S:T168	3.14	0	No	No	5	6	1	2
S:S:D171	S:S:T117	13.01	0	No	No	4	5	2	1
M:M:P23	S:S:T117	5.25	3	Yes	No	9	5	0	1
S:S:H203	S:S:L120	6.43	3	Yes	Yes	4	7	1	1
S:S:L120	S:S:W252	5.69	3	Yes	Yes	7	9	1	2
M:M:P23	S:S:L120	3.28	3	Yes	Yes	9	7	0	1
S:S:H203	S:S:Y121	5.44	3	Yes	No	4	7	1	2
S:S:P170	S:S:R188	2.88	0	Yes	Yes	8	5	2	1
S:S:D171	S:S:R188	14.29	0	No	Yes	4	5	2	1
S:S:I185	S:S:S178	3.1	0	No	Yes	3	1	2	1
S:S:F189	S:S:S178	3.96	0	No	Yes	3	1	1	1
M:M:S25	S:S:D187	7.36	0	No	No	9	3	0	1
M:M:S27	S:S:D187	8.83	0	No	No	6	3	0	1
S:S:R188	S:S:Y190	17.49	0	Yes	Yes	5	4	1	2
M:M:P23	S:S:R188	2.88	3	Yes	Yes	9	5	0	1
M:M:Y28	S:S:F189	9.28	0	No	No	8	3	0	1
S:S:L266	S:S:V197	4.47	0	No	No	3	3	1	2
S:S:D262	S:S:Q200	6.53	0	No	No	5	5	2	1
S:S:Q200	S:S:S263	5.78	0	No	No	5	5	1	2
M:M:V24	S:S:Q200	4.3	3	Yes	No	7	5	0	1
S:S:H203	S:S:Y255	6.53	3	Yes	Yes	4	7	1	1
S:S:H203	S:S:Y256	7.62	3	Yes	Yes	4	8	1	2
M:M:P23	S:S:H203	16.78	3	Yes	Yes	9	4	0	1
S:S:I204	S:S:I259	5.89	0	No	Yes	5	5	2	1
S:S:W252	S:S:Y255	5.79	3	Yes	Yes	9	7	2	1
S:S:Y255	S:S:Y256	4.96	3	Yes	Yes	7	8	1	2
S:S:I259	S:S:Y255	9.67	3	Yes	Yes	5	7	1	1
S:S:E288	S:S:Y255	5.61	0	No	Yes	5	7	1	1
M:M:V24	S:S:Y255	6.31	3	Yes	Yes	7	7	0	1
S:S:I259	S:S:Y256	3.63	3	Yes	Yes	5	8	1	2
S:S:I259	S:S:I284	4.42	3	Yes	No	5	4	1	2
M:M:V24	S:S:I259	3.07	3	Yes	Yes	7	5	0	1
S:S:D262	S:S:I284	4.2	0	No	No	5	4	2	2
S:S:E268	S:S:K271	4.05	9	No	Yes	2	3	1	1
M:M:R33	S:S:E268	10.47	9	No	No	9	2	0	1
M:M:R33	S:S:K271	3.71	9	No	Yes	9	3	0	1
M:M:F34	S:S:K271	3.72	9	No	Yes	6	3	0	1
M:M:R29	S:S:E277	6.98	0	Yes	No	9	2	0	1
M:M:L26	S:S:H281	7.71	0	No	No	9	4	0	1
M:M:L26	S:S:S285	3	0	No	No	9	5	0	1
M:M:K22	S:S:E288	8.1	3	Yes	No	9	5	0	1
M:M:R29	S:S:L266	2.43	0	Yes	No	9	3	0	1
S:S:F189	S:S:N176	2.42	0	No	No	3	4	1	2
M:M:P31	S:S:P27	1.95	0	No	No	7	5	0	1
S:S:A180	S:S:S178	1.71	0	No	Yes	1	1	2	1
S:S:N37	S:S:S285	1.49	0	Yes	No	3	5	2	1
M:M:N54	S:S:S178	1.49	0	No	Yes	8	1	0	1
J:J:N66	L:L:N66	1.36	0	No	No	5	5	0	1
M:M:E36	S:S:K25	1.35	0	No	Yes	6	4	0	1
S:S:E277	S:S:N278	1.31	0	No	No	2	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F29	R:R:P27	8.67	0	No	No	4	5	1	1
R:R:C274	R:R:C28	7.28	0	No	No	5	9	2	1
L:L:P31	R:R:F29	4.33	0	No	No	7	4	0	1
R:R:H281	R:R:R30	3.39	0	Yes	No	4	5	1	2
R:R:E32	R:R:H281	3.69	0	No	Yes	4	4	2	1
R:R:F87	R:R:Y116	6.19	1	Yes	Yes	7	6	2	1
R:R:F292	R:R:F87	10.72	1	No	Yes	7	7	2	2
R:R:D97	R:R:W94	3.35	0	No	Yes	5	7	2	1
R:R:V112	R:R:W94	6.13	6	Yes	Yes	5	7	2	1
R:R:H113	R:R:W94	7.41	6	Yes	Yes	6	7	2	1
L:L:K22	R:R:W94	12.76	1	No	Yes	9	7	0	1
R:R:D171	R:R:H113	3.78	0	No	Yes	4	6	2	2
R:R:E288	R:R:Y116	3.37	1	No	Yes	5	6	1	1
R:R:F292	R:R:Y116	6.19	1	No	Yes	7	6	2	1
L:L:K22	R:R:Y116	7.17	1	No	Yes	9	6	0	1
R:R:T117	R:R:Y121	3.75	0	Yes	Yes	5	7	1	2
R:R:T117	R:R:T168	3.14	0	Yes	No	5	6	1	2
R:R:D171	R:R:T117	10.12	0	No	Yes	4	5	2	1
L:L:P23	R:R:T117	5.25	1	No	Yes	9	5	0	1
R:R:H203	R:R:L120	5.14	1	Yes	No	4	7	1	1
R:R:L120	R:R:W252	4.56	1	No	Yes	7	9	1	2
L:L:P23	R:R:L120	3.28	1	No	No	9	7	0	1
R:R:H203	R:R:Y121	5.44	1	Yes	Yes	4	7	1	2
R:R:P170	R:R:R188	2.88	0	Yes	Yes	8	5	2	1
R:R:D171	R:R:R188	9.53	0	No	Yes	4	5	2	1
R:R:F189	R:R:S178	6.61	0	No	No	3	1	1	1
L:L:N54	R:R:S178	2.98	0	No	No	8	1	0	1
R:R:A180	R:R:I185	3.25	0	No	No	1	3	2	1
L:L:P53	R:R:D181	4.83	0	No	No	7	2	0	1
L:L:S27	R:R:I185	3.1	0	No	No	6	3	0	1
R:R:D187	R:R:R188	3.57	7	No	Yes	3	5	1	1
L:L:S25	R:R:D187	4.42	7	No	No	9	3	0	1
L:L:S27	R:R:D187	5.89	0	No	No	6	3	0	1
R:R:R188	R:R:Y190	14.4	7	Yes	Yes	5	4	1	2
L:L:S25	R:R:R188	5.27	7	No	Yes	9	5	0	1
L:L:Y28	R:R:F189	8.25	0	No	No	8	3	0	1
R:R:D262	R:R:Q200	6.53	1	Yes	No	5	5	1	1
R:R:Q200	R:R:S263	8.66	0	No	No	5	5	1	2
L:L:V24	R:R:Q200	4.3	1	No	No	7	5	0	1
R:R:H203	R:R:Y255	6.53	1	Yes	Yes	4	7	1	1
R:R:H203	R:R:Y256	8.71	1	Yes	Yes	4	8	1	2
L:L:P23	R:R:H203	13.73	1	No	Yes	9	4	0	1
R:R:I204	R:R:I259	5.89	0	No	Yes	5	5	2	1
R:R:W252	R:R:Y255	5.79	1	Yes	Yes	9	7	2	1
R:R:Y255	R:R:Y256	4.96	1	Yes	Yes	7	8	1	2
R:R:I259	R:R:Y255	8.46	1	Yes	Yes	5	7	1	1
R:R:E288	R:R:Y255	5.61	1	No	Yes	5	7	1	1
L:L:V24	R:R:Y255	5.05	1	No	Yes	7	7	0	1
R:R:I259	R:R:Y256	3.63	1	Yes	Yes	5	8	1	2
R:R:I259	R:R:I284	4.42	1	Yes	No	5	4	1	2
L:L:V24	R:R:I259	4.61	1	No	Yes	7	5	0	1
R:R:D262	R:R:V280	2.92	1	Yes	No	5	5	1	2
R:R:D262	R:R:I284	4.2	1	Yes	No	5	4	1	2
L:L:L26	R:R:E277	3.98	1	Yes	No	9	2	0	1
L:L:R29	R:R:E277	9.3	1	Yes	No	9	2	0	1
R:R:I284	R:R:V280	3.07	1	No	No	4	5	2	2
L:L:L26	R:R:H281	7.71	1	Yes	Yes	9	4	0	1
L:L:K22	R:R:E288	8.1	1	No	No	9	5	0	1
R:R:D262	R:R:L266	2.71	1	Yes	No	5	3	1	2
L:L:L26	R:R:D262	2.71	1	Yes	Yes	9	5	0	1
R:R:H281	R:R:N278	2.55	0	Yes	No	4	3	1	2
L:L:P31	R:R:C28	1.88	0	No	No	7	9	0	1
L:L:Q69	R:R:P27	1.58	0	No	No	9	5	0	1
R:R:E26	R:R:P27	1.57	0	No	No	2	5	2	1
L:L:T52	R:R:D181	1.45	0	No	No	8	2	0	1
L:L:R29	R:R:C28	1.39	1	Yes	No	9	9	0	1
J:J:N66	L:L:N66	1.36	0	No	No	5	5	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9ME1_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	1359
Number of Links	1461
Number of Hubs	182
Number of Links mediated by Hubs	653
Number of Communities	39
Number of Nodes involved in Communities	225
Number of Links involved in Communities	286

Path Summary
Number Of Nodes in MetaPath	167
Number Of Links MetaPath	166
Number of Shortest Paths	2268907
Length Of Smallest Path	3
Average Path Length	27.2438
Length of Longest Path	60
Minimum Path Strength	1.205
Average Path Strength	5.9077
Maximum Path Strength	19.625
Minimum Path Correlation	0.7
Average Path Correlation	0.995376
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.43902
Average % Of Corr. Nodes	66.7195
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.0781
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>9ME1_poly_Chain_R E P C F R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V N L Y S S V L I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	doi.org/10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	doi.org/10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	doi.org/10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	doi.org/10.1126/science.1261064
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	-	-	3.01	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	-	-	3.2	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	-	3.31	2025-02-26	doi.org/10.1073/pnas.2425795122
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	doi.org/10.1016/j.celrep.2025.115255
	9MDU	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	2.9	2025-09-10	To be published
	9ME1	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	-	3.37	2025-09-10	To be published
	9MEJ	A	Protein	Chemokine	CXCR4	Homo sapiens	Gp120	-	-	3.99	2025-09-10	To be published
	9MEN	A	Protein	Chemokine	CXCR4	Homo sapiens	Gp120 (V3 loop)	-	-	3.57	2025-09-10	To be published
	9MET	A	Protein	Chemokine	CXCR4	Homo sapiens	Gp120; CD4	-	-	5.65	2025-09-10	To be published
	9MEU	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	-	3.46	2025-09-10	To be published
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	Gi1/β1/γ2	2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ2	3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	Gi1/β1/γ2	3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-		3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	Gi1/β1/γ2	3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.1	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9ME1_poly.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.