Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N35 5.09254263
2R:R:L41 4.9125436
3R:R:Y45 6.148537
4R:R:F49 6.7875436
5R:R:M72 4.31754106
6R:R:Y76 6.0045107
7R:R:R77 9.1625438
8R:R:H79 4.8154109
9R:R:S81 4.595409
10R:R:L85 2.54407
11R:R:F87 8.8275437
12R:R:L91 3.608538
13R:R:W94 4.8525437
14R:R:W102 6.157149
15R:R:F104 7.45254147
16R:R:L108 2.524145
17R:R:Y116 3.632536
18R:R:Y121 5.08437
19R:R:S123 3.535439
20R:R:L127 4.6525438
21R:R:F129 4.19254105
22R:R:R134 3.22409
23R:R:Y135 4.4465228
24R:R:H140 3.23754226
25R:R:R148 7.854106
26R:R:V156 4.264105
27R:R:V160 4.7925407
28R:R:W161 3.116109
29R:R:D171 4.774534
30R:R:F174 6.3725434
31R:R:D187 4.184533
32R:R:R188 6.47635
33R:R:Y190 9.00167634
34R:R:W195 5.082535
35R:R:V196 3.185404
36R:R:F199 9.4375435
37R:R:Q200 5.588505
38R:R:H203 5.71434
39R:R:I209 2.545404
40R:R:I215 4.0125217
41R:R:Y219 3.7245218
42R:R:F248 5.85333639
43R:R:W252 6.87714739
44R:R:Y255 6.11837
45R:R:Y256 5.40833638
46R:R:I259 6.0125405
47R:R:D262 6.524205
48R:R:E275 4.35754173
49R:R:F276 4.5685171
50R:R:E277 6.4325202
51R:R:E288 6.1525435
52R:R:F292 4.86143737
53R:R:H294 7.895439
54R:R:N298 7.214539
55S:S:L41 4.205406
56S:S:Y45 3.57627
57S:S:I48 3.46427
58S:S:N56 3.605409
59S:S:M63 2.578506
60S:S:Y76 6.086676117
61S:S:D84 4.9629
62S:S:F87 6.12333627
63S:S:V88 3.7475406
64S:S:F93 6.5175426
65S:S:W94 2.56333627
66S:S:W102 6.53571729
67S:S:C109 4.76429
68S:S:H113 4.07167626
69S:S:Y116 3.866526
70S:S:L120 4.7575407
71S:S:Y121 6.155427
72S:S:F129 4.615115
73S:S:R134 4.166509
74S:S:Y135 3.74714798
75S:S:H140 6.122596
76S:S:Y157 4.29254117
77S:S:V160 4.9485117
78S:S:W161 7.35254119
79S:S:T168 4.1525426
80S:S:D171 5.478524
81S:S:F174 7.3325424
82S:S:R183 9.895403
83S:S:R188 6.435425
84S:S:Y190 9.418524
85S:S:F199 4.64525
86S:S:Q200 6.8825425
87S:S:H203 5.7575424
88S:S:Y219 4.22375898
89S:S:I222 3.395498
90S:S:S227 4.81754184
91S:S:L238 2.8475495
92S:S:F248 6.425629
93S:S:W252 8.62857729
94S:S:Y255 4.91571727
95S:S:Y256 8.1425408
96S:S:I259 4.765625
97S:S:I270 4.2275405
98S:S:F276 3.35331
99S:S:W283 7.285406
100S:S:E288 3.63425
101S:S:F292 4.49167627
102S:S:F293 3.6125425
103S:S:H294 6.80833629
104S:S:C295 4.975429
105S:S:C296 3.8925427
106C:C:F40 4.6825405
107C:C:L41 2.83456
108C:C:Y45 4.25167657
109C:C:F49 5.4875406
110C:C:N56 3.95409
111C:C:M63 4.7525406
112C:C:Y76 7.1875407
113C:C:D84 6.388559
114C:C:F87 8.41167657
115C:C:L91 2.948558
116C:C:F93 4.2875456
117C:C:W94 3.48714757
118C:C:H113 3.8525406
119C:C:Y116 4.068556
120C:C:N119 10.1675458
121C:C:L120 4.1825457
122C:C:Y121 6.075457
123C:C:S123 3.58459
124C:C:R134 3.2925129
125C:C:Y135 4.593336128
126C:C:I138 4.6054128
127C:C:F174 5.30254234
128C:C:R183 7.21403
129C:C:R188 12.175455
130C:C:N192 5.6254231
131C:C:F199 5.4025455
132C:C:F201 3.65404
133C:C:H203 7.3925454
134C:C:P211 2.1525409
135C:C:Y219 4.381676128
136C:C:F248 4.44167659
137C:C:W252 8.69559
138C:C:Y255 5.37714757
139C:C:Y256 5.97429758
140C:C:I259 5.715655
141C:C:F276 4.8645261
142C:C:E277 4.3125402
143C:C:W283 7.2945276
144C:C:F292 7.09167657
145C:C:H294 7.30875859
146C:C:C295 5.73459
147C:C:N298 5.554349
148C:C:Y302 10.0054349
149P:P:R30 5.695445
150P:P:N37 4.25403
151P:P:P42 3.5754325
152P:P:Y45 4.655647
153P:P:V54 2.795404
154P:P:N56 6.36409
155P:P:T73 2.835407
156P:P:Y76 4.835677
157P:P:R77 8.731676198
158P:P:F87 7.27714747
159P:P:L91 4.15857748
160P:P:W94 3.002547
161P:P:W102 9.2285169
162P:P:F104 10.06254167
163P:P:Y116 3.426546
164P:P:L120 4.086547
165P:P:Y121 6.526547
166P:P:F129 4.6425475
167P:P:Y135 4.936578
168P:P:L136 3.718575
169P:P:H140 5.316576
170P:P:R148 5.7576
171P:P:W161 5.043336379
172P:P:T168 5.34136
173P:P:D171 6.495134
174P:P:F174 5.4885134
175P:P:R183 7.1275403
176P:P:R188 5.54254135
177P:P:Y190 8.086676134
178P:P:W195 9.3154135
179P:P:H203 5.535444
180P:P:Y219 3.131676388
181P:P:F248 7.345649
182P:P:W252 6.49714749
183P:P:Y255 6.496547
184P:P:Y256 5.52429748
185P:P:I259 5.04667645
186P:P:D262 4.792545
187P:P:F276 4.206541
188P:P:E277 6.115442
189P:P:V280 3.94445
190P:P:W283 7.9525406
191P:P:I284 3.805444
192P:P:F292 6.09667647
193P:P:F293 5.5125405
194P:P:H294 5.94749
195P:P:C295 4.682549
196P:P:N298 5.0754199
197P:P:Y302 9.95254199
198L:L:W35 7.178519
199L:L:L42 4.852519
200L:L:T46 3.4525409
201L:L:W52 8.55833609
202L:L:D60 9.375419
203L:L:Y64 6.24518
204L:L:E66 9.088519
205L:L:F75 5.14143719
206L:L:A77 2.94418
207L:L:W78 7.7475817
208L:L:Q85 9.64419
209L:L:V87 4.1375416
210L:L:W91 12.035618
211L:L:L93 6.832518
212L:L:F94 4.6675418
213L:L:P100 8.825419
214L:L:D141 7.9325465
215L:L:W209 5.52167618
216L:L:M212 4.74333619
217L:L:F214 4.86519
218L:L:R215 5.39286719
219L:L:Y216 7.09778918
220L:L:C217 4.0175419
221L:L:P219 4.02509
222L:L:F222 6.56833617
223L:L:L224 3.1025417
224L:L:L225 4.624517
225L:L:R226 8.66571718
226L:L:C227 5.675419
227L:L:D229 1.51415
228L:L:Y232 4.15667618
229L:L:G234 5.535419
230L:L:C239 4.06419
231L:L:V243 3.97419
232L:L:C247 4.9175419
233L:L:R249 7.866519
234L:L:M251 3.664519
235L:L:T253 4.028519
236L:L:S256 4.42419
237L:L:W258 8.16519
238L:L:F259 3.71719
239L:L:F261 5.78333619
240L:L:R265 7.42571718
241L:L:Y271 9.95833615
242L:L:I272 6.5408
243L:L:Y273 7.05286718
244L:L:W274 9.242588
245L:L:H275 16.37414
246L:L:R280 10.2757714
247L:L:I282 6.43515
248L:L:L285 4.275419
249L:L:N286 6.62415
250L:L:Y289 5.7713
251L:L:H294 10.57464
252L:L:K301 1.51408
253L:L:L304 6.6404
254L:L:F312 4.432535
255L:L:K313 5.0625405
256L:L:H315 94205
257L:L:Q326 6.63465
258L:L:W328 6.57286765
259L:L:W330 4.632565
260L:L:F331 8.314515
261L:L:W335 9.21719
262L:L:K343 7.1275483
263L:L:L346 4.53333689
264L:L:H349 8.2584
265L:L:Y352 6.71684
266L:L:I362 7.14589
267L:L:F364 5.92833688
268L:L:P367 2.6925405
269L:L:P373 3.955415
270L:L:Y377 3.724515
271L:L:M378 5.132518
272L:L:W379 10.9214715
273L:L:T380 3.63418
274L:L:E385 4.964399
275L:L:L387 4.2775419
276L:L:Y388 7.91167618
277L:L:C389 4.112519
278L:L:M391 6.9425418
279L:L:W393 7.8825461
280L:L:F394 5.914519
281L:L:W397 2.982504
282L:L:R401 9.5854401
283L:L:R407 10.404564
284L:L:N408 5.755407
285L:L:Y409 8.47665
286L:L:P411 6.014564
287L:L:C412 4.3725419
288L:L:R415 12.1175416
289L:L:I418 4.73667615
290L:L:W421 6.11718
291L:L:N427 6.336518
292L:L:Y429 6.704519
293L:L:V443 4.42833619
294L:L:T444 3.082519
295L:L:S445 2.765419
296L:L:I446 3.745406
297L:L:I447 4.24415
298L:L:N449 5.16415
299L:L:I458 6.7425489
300L:L:F460 8.8409
301L:L:E463 9.298514
302L:L:V464 5.0175418
303L:L:E466 8.91333618
304L:L:Y468 5.3825419
305L:L:R469 3.75333619
306L:L:L470 5.284519
307L:L:L472 3.6625419
308L:L:D474 8.042518
309L:L:Y475 6.61444919
310L:L:K476 5.725419
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:K301 R:R:P27 85.29441.67YesNo085
2R:R:C28 R:R:P27 85.35323.77NoNo095
3L:L:V303 R:R:C28 85.47061.71NoNo089
4L:L:S316 L:L:V303 85.70456.46NoNo058
5L:L:M309 L:L:S316 85.73264.6NoNo2475
6L:L:L304 L:L:M309 85.87934.24YesNo047
7L:L:L304 R:R:A180 86.11154.73YesNo041
8R:R:A180 R:R:S178 86.16941.71NoNo011
9R:R:F189 R:R:S178 86.22733.96NoNo031
10R:R:D187 R:R:F189 86.2855.97YesNo033
11L:L:F312 R:R:D187 61.16963.58YesYes353
12L:L:K313 R:R:D187 26.05612.77YesYes053
13L:L:K313 R:R:W94 22.57564.64YesYes057
14R:R:W94 R:R:Y45 19.8853.86YesYes377
15R:R:L41 R:R:Y45 57.26811.72YesYes367
16R:R:L41 R:R:P42 57.00153.28YesNo365
17R:R:P42 R:R:V99 56.93621.77NoNo054
18C:C:I261 R:R:V99 56.8534.61NoNo054
19L:L:F312 R:R:Y255 65.29053.09YesYes357
20R:R:W252 R:R:Y255 65.92077.72YesYes397
21R:R:F248 R:R:W252 98.35589.02YesYes399
22R:R:F248 R:R:F249 98.48824.29YesNo094
23R:R:F249 R:R:I215 98.48172.51NoYes047
24R:R:I215 R:R:S131 96.82157.74YesNo2179
25R:R:C218 R:R:S131 1003.44NoNo069
26R:R:C218 R:R:Y135 99.99055.38NoYes068
27R:R:V139 R:R:Y135 99.74856.31NoYes2278
28R:R:K225 R:R:V139 99.99364.55NoNo047
29R:R:H228 R:R:K225 99.98342.62NoNo054
30R:R:H228 S:S:Q66 99.9736.18NoNo054
31R:R:S227 S:S:Q66 99.95217.22NoNo044
32R:R:S227 S:S:V62 99.94153.23NoNo047
33S:S:M63 S:S:V62 99.93093.04YesNo067
34S:S:M63 S:S:Y302 99.83262.39YesNo069
35S:S:V59 S:S:Y302 99.75272.52NoNo089
36S:S:S81 S:S:V59 99.7413.23NoNo098
37S:S:N56 S:S:S81 99.70562.98YesNo099
38S:S:D84 S:S:N56 99.50992.69YesYes099
39S:S:D84 S:S:H294 88.97942.52YesYes299
40S:S:H294 S:S:W252 75.636520.1YesYes299
41C:C:I261 R:R:I39 53.69384.42NoNo055
42C:C:W283 R:R:I39 53.608717.62YesNo065
43R:R:L80 R:R:N298 10.76426.87NoYes399
44S:S:W252 S:S:Y255 72.92424.82YesYes297
45S:S:F248 S:S:H294 10.18637.92YesYes299
46S:S:F248 S:S:L127 10.94336.09YesNo098
47S:S:I245 S:S:L127 10.84925.71NoNo078
48S:S:I245 S:S:Y219 10.75873.63NoYes078
49S:S:T287 S:S:Y255 76.6613.75NoYes067
50S:S:P254 S:S:T287 75.07183.5NoNo096
51S:S:L253 S:S:P254 74.23426.57NoNo059
52P:P:I47 S:S:L253 74.19172.85NoNo045
53P:P:F293 P:P:I47 74.14972.51YesNo054
54P:P:F293 P:P:I48 73.71987.54YesNo057
55P:P:C295 P:P:I48 32.5374.91YesNo097
56P:P:T287 P:P:W283 15.467313.34NoYes066
57P:P:T287 P:P:Y255 17.28872.5NoYes067
58P:P:Y116 P:P:Y255 21.55942.98YesYes467
59P:P:F87 P:P:Y116 17.13992.06YesYes476
60P:P:I48 P:P:L91 41.24022.85NoYes078
61P:P:I259 P:P:I284 22.57864.42YesYes454
62P:P:I259 P:P:Y255 26.30379.67YesYes457
63P:P:F292 P:P:L91 29.13462.44YesYes478
64P:P:W252 P:P:Y255 15.22683.86YesYes497
65P:P:F292 P:P:W252 13.76472YesYes479
66P:P:W252 P:P:Y256 10.21037.72YesYes498
67P:P:H294 P:P:W252 14.103412.7YesYes499
68P:P:C295 P:P:H294 18.06182.95YesYes499
69C:C:T287 C:C:Y255 52.84134.99NoYes067
70C:C:T287 C:C:W283 52.92687.28NoYes066
71C:C:W252 C:C:Y255 23.30216.75YesYes597
72C:C:R134 C:C:T73 18.50223.88YesNo097
73C:C:L238 C:C:R134 12.60662.43NoYes059
74C:C:L238 C:C:Y219 13.86383.52NoYes058
75C:C:S131 C:C:Y219 14.06962.54NoYes1298
76C:C:I215 C:C:S131 18.476710.84NoNo079
77C:C:I215 C:C:P211 32.95921.69NoYes079
78C:C:P211 C:C:V124 33.77881.77YesNo097
79C:C:G207 C:C:V124 16.77861.84NoNo057
80C:C:G207 C:C:Y256 16.87794.35NoYes058
81C:C:Y255 C:C:Y256 19.80731.99YesYes578
82C:C:R134 C:C:T241 12.60533.88YesNo097
83C:C:T241 C:C:Y219 13.44342.5NoYes078
84C:C:I245 C:C:Y219 14.07016.04NoYes078
85C:C:I215 C:C:I245 14.27754.42NoNo077
86C:C:F248 C:C:V124 17.20962.62YesNo097
87C:C:F248 C:C:W252 17.32910.02YesYes599
88C:C:I130 C:C:Y76 12.61686.04NoYes087
89C:C:I130 C:C:T73 13.45743.04NoNo087
90P:P:I259 P:P:Q200 12.20275.49YesNo055
91P:P:D262 P:P:Q200 11.59323.92YesNo055
92P:P:D262 P:P:I284 11.59334.2YesYes454
93P:P:D262 P:P:E277 14.65753.9YesYes452
94L:L:K301 L:L:R139 84.99961.24YesNo085
95L:L:R139 L:L:T135 84.94052.59NoNo057
96L:L:N133 L:L:T135 84.88121.46NoNo087
97L:L:N133 L:L:N408 84.8221.36NoYes087
98L:L:N408 L:L:W397 77.15784.52YesYes074
99L:L:W335 L:L:W397 40.94661.87YesYes094
100L:L:F259 L:L:W335 20.42674.01YesYes199
101L:L:F259 L:L:F261 29.46712.14YesYes199
102L:L:F261 L:L:S256 29.64453.96YesYes199
103L:L:G260 L:L:S256 29.86541.86NoYes199
104L:L:G260 L:L:S445 27.91531.86NoYes199
105L:L:L470 L:L:S445 24.38213YesYes199
106L:L:F394 L:L:W397 35.8564.01YesYes094
107L:L:F259 L:L:F394 20.33094.29YesYes199
108L:L:V443 L:L:W335 14.80116.13YesYes199
109L:L:F261 L:L:V443 14.70727.87YesYes199
110L:L:M250 L:L:R215 11.6742.48NoYes089
111L:L:M250 L:L:R213 11.942611.17NoNo089
112L:L:E252 L:L:R213 12.22056.98NoNo059
113L:L:E252 L:L:Q254 12.49693.82NoNo058
114L:L:F261 L:L:Q254 12.686812.88YesNo198
115L:L:T257 L:L:W379 10.41848.49NoYes095
116L:L:T257 L:L:W258 10.62084.85NoYes099
117L:L:M391 L:L:W258 13.32936.98YesYes189
118L:L:F394 L:L:M391 15.26357.46YesYes198
119L:L:L470 L:L:R265 10.27813.64YesYes198
120R:R:F292 R:R:Y45 37.72324.13YesYes377
121R:R:F292 R:R:W252 36.9932YesYes379
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:N142 R:R:E26 2.63 0 No No 4 2 0 1
R:R:C28 R:R:P27 3.77 0 No No 9 5 1 1
R:R:C28 R:R:R30 4.18 0 No No 9 5 1 2
R:R:E277 R:R:F29 3.5 20 Yes No 2 4 1 2
L:L:M309 R:R:E31 8.12 24 No No 7 5 0 1
L:L:S316 R:R:E31 5.75 24 No No 5 5 0 1
R:R:W94 R:R:Y45 3.86 3 Yes Yes 7 7 1 2
R:R:F292 R:R:Y45 4.13 3 Yes Yes 7 7 2 2
R:R:V112 R:R:W94 4.9 0 No Yes 5 7 2 1
R:R:F292 R:R:W94 6.01 3 Yes Yes 7 7 2 1
L:L:K313 R:R:W94 4.64 0 Yes Yes 5 7 0 1
R:R:D171 R:R:H113 7.56 3 Yes No 4 6 2 2
R:R:H113 R:R:R188 4.51 3 No Yes 6 5 2 1
R:R:L120 R:R:Y116 4.69 0 No Yes 7 6 2 2
R:R:Y116 R:R:Y255 2.98 3 Yes Yes 6 7 2 1
R:R:E288 R:R:Y116 2.24 3 Yes Yes 5 6 1 2
R:R:F292 R:R:Y116 3.09 3 Yes Yes 7 6 2 2
R:R:D171 R:R:T117 4.34 3 Yes No 4 5 2 2
R:R:R188 R:R:T117 3.88 3 Yes No 5 5 1 2
R:R:H203 R:R:L120 6.43 3 Yes No 4 7 1 2
R:R:L120 R:R:W252 3.42 0 No Yes 7 9 2 2
R:R:D171 R:R:R188 5.96 3 Yes Yes 4 5 2 1
R:R:F189 R:R:S178 3.96 0 No No 3 1 2 2
L:L:L304 R:R:A180 4.73 0 Yes No 4 1 0 1
L:L:L304 R:R:D181 10.86 0 Yes No 4 2 0 1
R:R:I185 R:R:R183 6.26 0 No No 3 3 1 2
L:L:F314 R:R:I185 3.77 0 No No 4 3 0 1
R:R:D187 R:R:R188 3.57 3 Yes Yes 3 5 1 1
R:R:D187 R:R:F189 5.97 3 Yes No 3 3 1 2
L:L:G311 R:R:D187 5.03 0 No Yes 9 3 0 1
L:L:F312 R:R:D187 3.58 3 Yes Yes 5 3 0 1
L:L:K313 R:R:D187 2.77 0 Yes Yes 5 3 0 1
R:R:R188 R:R:Y190 12.35 3 Yes Yes 5 4 1 2
L:L:F312 R:R:R188 8.55 3 Yes Yes 5 5 0 1
R:R:V196 R:R:Y190 5.05 0 Yes Yes 4 4 1 2
R:R:D193 R:R:L266 8.14 0 No No 1 3 1 1
R:R:Q200 R:R:V196 2.87 0 Yes Yes 5 4 1 1
R:R:L266 R:R:V196 2.98 0 No Yes 3 4 1 1
L:L:G311 R:R:V196 1.84 0 No Yes 9 4 0 1
R:R:I259 R:R:Q200 8.23 0 Yes Yes 5 5 2 1
R:R:D262 R:R:Q200 7.83 20 Yes Yes 5 5 1 1
R:R:Q200 R:R:S263 4.33 0 Yes No 5 5 1 2
L:L:F312 R:R:Q200 4.68 3 Yes Yes 5 5 0 1
R:R:H203 R:R:Y255 5.44 3 Yes Yes 4 7 1 1
R:R:H203 R:R:Y256 8.71 3 Yes Yes 4 8 1 2
L:L:F312 R:R:H203 2.26 3 Yes Yes 5 4 0 1
R:R:W252 R:R:Y255 7.72 3 Yes Yes 9 7 2 1
R:R:W252 R:R:Y256 3.86 3 Yes Yes 9 8 2 2
R:R:F292 R:R:W252 2 3 Yes Yes 7 9 2 2
R:R:Y255 R:R:Y256 3.97 3 Yes Yes 7 8 1 2
R:R:I259 R:R:Y255 8.46 0 Yes Yes 5 7 2 1
R:R:T287 R:R:Y255 3.75 0 No Yes 6 7 2 1
R:R:E288 R:R:Y255 13.47 3 Yes Yes 5 7 1 1
L:L:F312 R:R:Y255 3.09 3 Yes Yes 5 7 0 1
R:R:D262 R:R:V280 4.38 20 Yes No 5 5 1 2
R:R:D262 R:R:H281 2.52 20 Yes No 5 4 1 1
L:L:H315 R:R:D262 11.35 20 Yes Yes 5 5 0 1
R:R:E277 R:R:I265 2.73 20 Yes No 2 3 1 2
L:L:H315 R:R:L266 7.71 20 Yes No 5 3 0 1
R:R:E277 R:R:H281 17.23 20 Yes No 2 4 1 1
L:L:H315 R:R:E277 7.39 20 Yes Yes 5 2 0 1
L:L:H315 R:R:H281 9.55 20 Yes No 5 4 0 1
R:R:E288 R:R:F292 3.5 3 Yes Yes 5 7 1 2
L:L:K313 R:R:E288 5.4 0 Yes Yes 5 5 0 1
L:L:V303 R:R:C28 1.71 0 No No 8 9 0 1
R:R:A180 R:R:S178 1.71 0 No No 1 1 1 2
L:L:K301 R:R:P27 1.67 0 Yes No 8 5 0 1
L:L:S310 R:R:D193 1.47 0 No No 8 1 0 1
L:L:K317 R:R:E268 1.35 0 No No 1 2 0 1
R:R:D181 R:R:D182 1.33 0 No No 2 6 1 2
R:R:E277 R:R:N278 1.31 20 Yes No 2 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9MEJ_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 1.77
Number of Linked Nodes 1405
Number of Links 1811
Number of Hubs 310
Number of Links mediated by Hubs 1126
Number of Communities 40
Number of Nodes involved in Communities 461
Number of Links involved in Communities 720
Path Summary
Number Of Nodes in MetaPath 122
Number Of Links MetaPath 121
Number of Shortest Paths 5663262
Length Of Smallest Path 3
Average Path Length 42.2268
Length of Longest Path 75
Minimum Path Strength 1.19
Average Path Strength 4.71619
Maximum Path Strength 21.98
Minimum Path Correlation 0.7
Average Path Correlation 0.998467
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.08163
Average % Of Corr. Nodes 58.0872
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.9996
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• viral process   • fusion of virus membrane with host endosome membrane   • membrane fusion involved in viral entry into host cell   • virion attachment to host cell   • biological process involved in interspecies interaction between organisms   • adhesion of symbiont to host cell   • viral life cycle   • adhesion of symbiont to host   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • symbiont-mediated perturbation of host defense response   • symbiont-mediated perturbation of host process   • symbiont-mediated-mediated suppression of host tetherin activity   • modulation of process of another organism   • import into cell   • receptor-mediated endocytosis of virus by host cell   • transport   • establishment of localization   • vesicle-mediated transport   • localization   • symbiont entry into host cell   • clathrin-dependent endocytosis   • symbiont entry into host   • cellular process   • clathrin-dependent endocytosis of virus by host cell   • receptor-mediated endocytosis   • endocytosis   • endocytosis involved in viral entry into host cell   • symbiont-mediated suppression of host immune response   • symbiont-mediated suppression of host innate immune response   • symbiont-mediated perturbation of host immune response   • symbiont-mediated perturbation of host innate immune response   • virion component   • virion membrane   • host intracellular membrane-bounded organelle   • host cellular component   • host intracellular part   • host cell membrane   • other organism part   • host cell cytoplasm part   • host intracellular organelle   • cellular anatomical structure   • host cell endosome membrane   • host cell cytoplasm   • host cell part   • host cell endosome
Gene OntologyCellular Component• virion component   • virion membrane   • host intracellular membrane-bounded organelle   • host cellular component   • host intracellular part   • host cell membrane   • other organism part   • host cell cytoplasm part   • host intracellular organelle   • cellular anatomical structure   • host cell endosome membrane   • host cell cytoplasm   • host cell part   • host cell endosome   • host intracellular region   • viral membrane   • viral envelope   • host cell plasma membrane   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • cytoskeletal protein binding   • myosin light chain binding   • protein binding   • binding   • myosin binding   • C-C chemokine binding   • chemokine binding   • cytokine binding   • G protein-coupled chemoattractant receptor activity   • C-X-C motif chemokine 12 receptor activity   • C-X-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • enzyme binding   • virus receptor activity   • exogenous protein binding   • C-C chemokine receptor activity   • ubiquitin binding   • ubiquitin-like protein binding   • actin binding   • developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • regulation of biological process   • cell adhesion   • regulation of cellular process   • regulation of cell adhesion   • biological regulation   • cellular process   • apoptotic process   • cell death   • programmed cell death   • membrane organization   • cellular component organization   • myelination   • myelin maintenance   • axon ensheathment   • ensheathment of neurons   • plasma membrane organization   • cellular component organization or biogenesis   • endomembrane system organization   • cell chemotaxis   • cellular response to stimulus   • chemotaxis   • dendritic cell chemotaxis   • response to stimulus   • response to external stimulus   • leukocyte migration   • dendritic cell migration   • cellular response to chemical stimulus   • taxis   • immune system process   • response to chemical   • mononuclear cell migration   • cell migration   • cell motility   • leukocyte chemotaxis   • locomotion   • response to decreased oxygen levels   • response to hypoxia   • response to stress   • response to oxygen levels   • response to abiotic stimulus   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • neurogenesis   • cellular developmental process   • cell differentiation   • immune response   • cell surface receptor signaling pathway   • chemokine (C-X-C motif) ligand 12 signaling pathway   • signaling   • CXCL12-activated CXCR4 signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • cell communication   • response to peptide   • G protein-coupled receptor signaling pathway   • cellular response to cytokine stimulus   • signal transduction   • C-X-C chemokine receptor CXCR4 signaling pathway   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • regulation of multicellular organismal development   • regulation of developmental process   • positive regulation of biological process   • vasculature development   • regulation of vasculature development   • circulatory system development   • positive regulation of developmental process   • positive regulation of vasculature development   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of macrophage migration inhibitory factor signaling pathway   • positive regulation of response to cytokine stimulus   • positive regulation of response to stimulus   • macrophage migration inhibitory factor signaling pathway   • positive regulation of cellular process   • regulation of signaling   • regulation of macrophage migration inhibitory factor signaling pathway   • regulation of cytokine-mediated signaling pathway   • regulation of response to cytokine stimulus   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of cytokine-mediated signaling pathway   • positive regulation of signaling   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to external biotic stimulus   • response to virus   • response to biotic stimulus   • defense response   • inflammatory response   • positive regulation of nervous system development   • cell development   • regulation of neurogenesis   • regulation of cell differentiation   • regulation of gliogenesis   • positive regulation of gliogenesis   • regulation of cell development   • regulation of nervous system development   • gliogenesis   • positive regulation of cell differentiation   • positive regulation of neurogenesis   • positive regulation of oligodendrocyte differentiation   • positive regulation of cell development   • regulation of glial cell differentiation   • positive regulation of glial cell differentiation   • oligodendrocyte differentiation   • glial cell differentiation   • regulation of oligodendrocyte differentiation   • cell periphery   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell leading edge   • intracellular anatomical structure   • cytoplasm   • anchoring junction   • cell junction   • intracellular organelle   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • lysosome   • protein-containing complex   • cytoplasmic vesicle   • intracellular vesicle   • early endosome   • endosome   • endomembrane system   • late endosome
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP61073
Sequence
>9MEJ_poly_Chain_R
EPCFREENA NFNKIFLPT IYSIIFLTG IVGNGLVIL VMGYQKKLR 
SMTDKYRLH LSVADLLFV ITLPFWAVD AVANWYFGN FLCKAVHVI 
YTVNLYSSV LILAFISLD RYLAIVHAT NSQRPRKLL AEKVVYVGV 
WIPALLLTI PDFIFANVS EADDRYICD RFYPNDLWV VVFQFQHIM 
VGLILPGIV ILSCYCIII SKLSHSKGH QKRKALKTT VILILAFFA 
CWLPYYIGI SIDSFILLE IIKQGCEFE NTVHKWISI TEALAFFHC 
CLNPILYAF LG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainL
ProteinGP120
UniProtP05883
Sequence
>9MEJ_poly_Chain_L
PAWRNASIP LFCATKNRD TWGTIQCLP DNDDYQEIL NVTEAFDAW 
NNTVTEQAV EDVWNLFET SIKPCVKLT PLQNITIIN DTSRADNCT 
GLKEEHYWD AMRFRYCAP PGFALLRCN DTNYSGFAP NCSKVVAAT 
CTRMMETQS TWFGFNGTR AENRTYIYW HGKNRTIIS LNNFYNLTM 
HCKRPGNKT VLPIMSGFK FHSPVINKK PRQAWCWFG WKEAMQEVK 
ETLAKHPRY KGNRSRTEN IKFKAPGRG SDPEYMWTN CRGELYCNM 
TWFLNWVNR TGQKQRNYA PCIRQIINT WHRVGKNYL PPREGELTC 
NSTVTSIIA NIDGDQTIT FSAEAELYR LELGDYKLV EIASNKKEA 
AFDHVTDV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3ODUAProteinChemokineCXCR4Homo sapiensIT1t--2.52010-10-27doi.org/10.1126/science.1194396
3OE0AProteinChemokineCXCR4Homo sapiensCVX15--2.92010-10-27doi.org/10.1126/science.1194396
3OE6AProteinChemokineCXCR4Homo sapiensIT1t--3.22010-10-27doi.org/10.1126/science.1194396
3OE8AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
3OE9AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
4RWSAProteinChemokineCXCR4Homo sapiensvMIP-II--3.12015-02-11doi.org/10.1126/science.1261064
8K3ZAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ12.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8K3Z (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-2.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8ZPLAProteinChemokineCXCR4Homo sapiensHF51116--3.012025-02-26doi.org/10.1073/pnas.2425795122
8ZPMAProteinChemokineCXCR4Homo sapiensAMD070--3.22025-02-26doi.org/10.1073/pnas.2425795122
8ZPNAProteinChemokineCXCR4Homo sapiensAMD3100--3.312025-02-26doi.org/10.1073/pnas.2425795122
8YU7AProteinChemokineCXCR4Homo sapiens---3.012025-03-05doi.org/10.1016/j.celrep.2025.115255
9MDUAProteinChemokineCXCR4Homo sapiens---2.92025-09-10To be published
9ME1AProteinChemokineCXCR4Homo sapiensCXCL12--3.372025-09-10To be published
9MEJAProteinChemokineCXCR4Homo sapiensGp120--3.992025-09-10To be published
9MENAProteinChemokineCXCR4Homo sapiensGp120 (V3 loop)--3.572025-09-10To be published
9METAProteinChemokineCXCR4Homo sapiensGp120; CD4--5.652025-09-10To be published
9MEUAProteinChemokineCXCR4Homo sapiensCXCL12--3.462025-09-10To be published
8U4NAProteinChemokineCXCR4Homo sapiens--Gi1/β1/γ22.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4N (No Gprot) AProteinChemokineCXCR4Homo sapiens--2.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4OAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ23.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4O (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-3.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4PAProteinChemokineCXCR4Homo sapiensAMD3100-Gi1/β1/γ23.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4P (No Gprot) AProteinChemokineCXCR4Homo sapiensAMD3100-3.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4QAProteinChemokineCXCR4Homo sapiensREGN7663-Fab-Gi1/β1/γ23.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4Q (No Gprot) AProteinChemokineCXCR4Homo sapiensREGN7663-Fab-3.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4RAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.12024-03-13doi.org/10.1101/2024.02.09.579708
8U4SAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.352024-03-13doi.org/10.1038/s41594-024-01397-1
8U4TAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.382024-03-13doi.org/10.1038/s41594-024-01397-1




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Download 9MEJ_poly.zip



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