psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	17.89	Yes	Yes	1	0	0
2	L:L:Y1	R:R:Y129	7.94	Yes	No	0	0	5
3	L:L:Y1	R:R:M132	8.38	Yes	Yes	1	0	8
4	L:L:Y1	R:R:V217	7.57	Yes	No	1	0	5
5	L:L:Y1	R:R:I277	3.63	Yes	No	1	0	5
6	L:L:Y1	R:R:V281	6.31	Yes	No	0	0	6
7	L:L:?2	L:L:G3	6.96	Yes	No	0	0	0
8	L:L:?2	L:L:?5	13.49	Yes	No	0	0	0
9	L:L:?2	R:R:I277	4.36	Yes	No	1	0	5
10	L:L:?2	R:R:I304	8.71	Yes	Yes	1	0	5
11	L:L:F4	R:R:Q105	5.86	Yes	Yes	3	0	5
12	L:L:F4	R:R:K108	6.2	Yes	No	3	0	4
13	L:L:F4	R:R:W114	5.01	Yes	Yes	3	0	8
14	L:L:F4	R:R:L125	15.83	Yes	No	0	0	5
15	L:L:F4	R:R:D128	5.97	Yes	No	3	0	5
16	L:L:F4	R:R:C198	5.59	Yes	No	3	0	9
17	L:L:?5	R:R:K214	7.37	No	Yes	0	0	5
18	L:L:?5	R:R:W284	19.83	No	No	0	0	4
19	R:R:A298	R:R:L48	4.73	No	No	0	1	2
20	R:R:I52	R:R:Y56	3.63	Yes	Yes	1	5	7
21	R:R:I52	R:R:Y109	9.67	Yes	No	1	5	4
22	R:R:H301	R:R:I52	9.28	Yes	Yes	1	4	5
23	R:R:L110	R:R:T53	11.79	No	No	0	4	6
24	R:R:A305	R:R:L55	4.73	No	No	0	5	5
25	R:R:L102	R:R:Y56	5.86	No	Yes	0	7	7
26	R:R:S106	R:R:Y56	3.82	No	Yes	0	6	7
27	R:R:H301	R:R:Y56	13.07	Yes	Yes	1	4	7
28	R:R:I304	R:R:Y56	9.67	Yes	Yes	1	5	7
29	R:R:S312	R:R:V59	4.85	No	No	0	7	7
30	R:R:C60	R:R:L102	6.35	No	No	0	6	7
31	R:R:C60	R:R:P103	3.77	No	No	0	6	8
32	R:R:S312	R:R:V62	6.46	No	No	0	7	4
33	R:R:G63	R:R:T99	3.64	No	No	0	8	6
34	R:R:G63	R:R:S312	3.71	No	No	0	8	7
35	R:R:L64	R:R:T99	4.42	No	No	0	6	6
36	R:R:G66	R:R:P315	4.06	No	No	0	7	9
37	R:R:A92	R:R:N67	4.69	No	No	0	9	9
38	R:R:D95	R:R:N67	6.73	Yes	No	0	9	9
39	R:R:N67	R:R:P315	9.77	No	No	0	9	9
40	R:R:F89	R:R:M71	7.46	Yes	No	0	6	7
41	R:R:F72	R:R:R76	8.55	No	No	0	4	5
42	R:R:F89	R:R:I74	6.28	Yes	No	0	6	7
43	R:R:F325	R:R:I74	6.28	Yes	No	0	8	7
44	R:R:F89	R:R:V75	3.93	Yes	No	0	6	3
45	R:R:R76	R:R:Y77	16.46	No	Yes	0	5	5
46	R:R:L332	R:R:Y77	14.07	No	Yes	0	5	5
47	R:R:N85	R:R:T78	5.85	No	No	5	8	6
48	R:R:F325	R:R:T78	9.08	Yes	No	5	8	6
49	R:R:I86	R:R:M80	5.83	Yes	No	0	6	7
50	R:R:F89	R:R:M80	6.22	Yes	No	0	6	7
51	R:R:N85	R:R:T82	11.7	No	No	0	8	7
52	R:R:R160	R:R:T84	3.88	Yes	No	0	6	8
53	R:R:F325	R:R:N85	4.83	Yes	No	5	8	8
54	R:R:A165	R:R:I86	4.87	No	Yes	0	7	6
55	R:R:I86	R:R:K166	7.27	Yes	No	0	6	3
56	R:R:I86	R:R:N169	4.25	Yes	No	0	6	7
57	R:R:M141	R:R:Y87	10.78	Yes	Yes	2	7	7
58	R:R:M142	R:R:Y87	5.99	Yes	Yes	2	9	7
59	R:R:D145	R:R:Y87	11.49	No	Yes	0	8	7
60	R:R:I168	R:R:Y87	7.25	No	Yes	2	5	7
61	R:R:N169	R:R:Y87	9.3	No	Yes	0	7	7
62	R:R:I88	R:R:M142	4.37	No	Yes	0	8	9
63	R:R:F325	R:R:I88	5.02	Yes	No	0	8	8
64	R:R:N169	R:R:N90	13.62	No	No	0	7	9
65	R:R:N90	R:R:W173	5.65	No	Yes	0	9	9
66	R:R:D95	R:R:L91	8.14	Yes	Yes	2	9	9
67	R:R:L91	R:R:T138	5.9	Yes	No	0	9	8
68	R:R:L139	R:R:L91	5.54	No	Yes	2	8	9
69	R:R:L91	R:R:N314	10.98	Yes	Yes	2	9	9
70	R:R:L91	R:R:Y318	4.69	Yes	Yes	2	9	9
71	R:R:L93	R:R:W173	5.69	No	Yes	0	6	9
72	R:R:D95	R:R:S135	7.36	Yes	No	0	9	9
73	R:R:D95	R:R:S311	10.31	Yes	No	0	9	9
74	R:R:D95	R:R:N314	8.08	Yes	Yes	2	9	9
75	R:R:L97	R:R:N131	10.98	No	No	0	7	8
76	R:R:Q105	R:R:T101	4.25	Yes	No	3	5	7
77	R:R:T101	R:R:Y308	4.99	No	Yes	3	7	7
78	R:R:L102	R:R:Y308	14.07	No	Yes	0	7	7
79	R:R:F104	R:R:F116	8.57	No	Yes	0	6	7
80	R:R:F104	R:R:V124	14.42	No	No	0	6	5
81	R:R:D128	R:R:Q105	6.53	No	Yes	3	5	5
82	R:R:Q105	R:R:Y308	11.27	Yes	Yes	3	5	7
83	R:R:K108	R:R:W114	5.8	No	Yes	3	4	8
84	R:R:V297	R:R:Y109	3.79	No	No	0	4	4
85	R:R:H301	R:R:Y109	16.33	Yes	No	1	4	4
86	R:R:M111	R:R:P115	6.71	No	No	0	4	3
87	R:R:F116	R:R:W114	20.04	Yes	Yes	0	7	8
88	R:R:C121	R:R:W114	5.22	No	Yes	3	9	8
89	R:R:V124	R:R:W114	4.9	No	Yes	0	5	8
90	R:R:C198	R:R:W114	13.06	No	Yes	3	9	8
91	R:R:F116	R:R:P115	14.45	Yes	No	0	7	3
92	R:R:F116	R:R:L120	6.09	Yes	No	0	7	6
93	R:R:E118	R:R:T189	8.47	No	No	0	4	4
94	R:R:C121	R:R:C198	7.28	No	No	3	9	9
95	R:R:L125	R:R:L200	4.15	No	No	0	5	4
96	R:R:M184	R:R:S126	9.2	No	No	0	4	6
97	R:R:I127	R:R:N131	5.66	No	No	0	5	8
98	R:R:D128	R:R:Y308	8.05	No	Yes	3	5	7
99	R:R:I183	R:R:Y129	14.51	No	No	0	4	5
100	R:R:T134	R:R:Y130	7.49	Yes	Yes	6	8	5
101	R:R:W173	R:R:Y130	11.58	Yes	Yes	6	9	5
102	R:R:S177	R:R:Y130	6.36	No	Yes	0	4	5
103	R:R:N131	R:R:T134	4.39	No	Yes	0	8	8
104	R:R:F133	R:R:M132	3.73	Yes	Yes	0	7	8
105	R:R:M132	R:R:V217	4.56	Yes	No	1	8	5
106	R:R:M132	R:R:W274	5.82	Yes	Yes	1	8	8
107	R:R:F133	R:R:F137	6.43	Yes	No	0	7	6
108	R:R:F133	R:R:V179	9.18	Yes	No	0	7	4
109	R:R:A221	R:R:F133	4.16	No	Yes	0	6	7
110	R:R:T134	R:R:W173	19.41	Yes	Yes	6	8	9
111	R:R:F270	R:R:I136	8.79	Yes	No	1	9	7
112	R:R:I136	R:R:W274	10.57	No	Yes	1	7	8
113	R:R:L139	R:R:N314	6.87	No	Yes	2	8	9
114	R:R:L139	R:R:Y318	4.69	No	Yes	2	8	9
115	R:R:I228	R:R:T140	4.56	No	No	0	7	7
116	R:R:I229	R:R:T140	7.6	No	No	0	8	7
117	R:R:M141	R:R:V144	4.56	Yes	No	0	7	7
118	R:R:I168	R:R:M141	5.83	No	Yes	2	5	7
119	R:R:M142	R:R:R146	3.72	Yes	No	2	9	9
120	R:R:M142	R:R:Y318	9.58	Yes	Yes	2	9	9
121	R:R:I229	R:R:S143	7.74	No	No	0	8	9
122	R:R:C232	R:R:S143	5.16	No	No	0	8	9
123	R:R:S143	R:R:Y233	8.9	No	Yes	0	9	8
124	R:R:D145	R:R:R160	17.87	No	Yes	0	8	6
125	R:R:R146	R:R:Y233	10.29	No	Yes	2	9	8
126	R:R:R146	R:R:Y318	9.26	No	Yes	2	9	9
127	R:R:I148	R:R:Y147	3.63	No	Yes	0	5	8
128	R:R:C151	R:R:Y147	6.72	No	Yes	0	7	8
129	R:R:H152	R:R:Y147	8.71	No	Yes	0	6	8
130	R:R:C232	R:R:Y147	6.72	No	Yes	0	8	8
131	R:R:L235	R:R:Y147	7.03	No	Yes	0	4	8
132	R:R:F159	R:R:I148	6.28	No	No	0	3	5
133	R:R:A149	R:R:R160	5.53	No	Yes	0	8	6
134	R:R:M236	R:R:V150	6.09	No	No	2	8	8
135	R:R:L240	R:R:V150	4.47	No	No	2	8	8
136	R:R:D158	R:R:K164	8.3	No	No	0	4	4
137	R:R:F159	R:R:I168	3.77	No	No	0	3	5
138	R:R:K164	R:R:T161	6.01	No	No	0	4	7
139	R:R:I183	R:R:L200	5.71	No	No	0	4	4
140	R:R:F202	R:R:M186	6.22	Yes	No	0	6	4
141	R:R:R190	R:R:V188	17	Yes	No	7	3	4
142	R:R:Q201	R:R:V188	5.73	No	No	7	4	4
143	R:R:M199	R:R:R190	3.72	No	Yes	0	4	3
144	R:R:Q201	R:R:R190	9.35	No	Yes	7	4	3
145	R:R:D193	R:R:R192	5.96	No	No	0	1	1
146	R:R:R192	R:R:V197	11.77	No	No	0	1	4
147	R:R:M199	R:R:R192	3.72	No	No	0	4	1
148	R:R:F202	R:R:L200	7.31	Yes	No	0	6	4
149	R:R:D210	R:R:F202	13.14	No	Yes	0	4	6
150	R:R:F202	R:R:T213	9.08	Yes	No	0	6	6
151	R:R:P205	R:R:S204	5.34	No	No	0	2	4
152	R:R:P205	R:R:W207	4.05	No	No	8	2	3
153	R:R:P205	R:R:Y208	4.17	No	No	8	2	3
154	R:R:W207	R:R:Y208	3.86	No	No	8	3	3
155	R:R:V212	R:R:Y208	8.83	No	No	0	4	3
156	R:R:V212	R:R:W209	3.68	No	No	0	4	4
157	R:R:D210	R:R:K214	9.68	No	Yes	0	4	5
158	R:R:K214	R:R:V281	7.59	Yes	No	0	5	6
159	R:R:C216	R:R:F220	5.59	No	No	0	3	4
160	R:R:F218	R:R:F222	6.43	Yes	Yes	1	5	8
161	R:R:F218	R:R:V223	7.87	Yes	No	0	5	4
162	R:R:F218	R:R:H278	4.53	Yes	No	1	5	7
163	R:R:F218	R:R:I282	7.54	Yes	No	0	5	6
164	R:R:L219	R:R:V223	4.47	No	No	0	4	4
165	R:R:F222	R:R:F270	4.29	Yes	Yes	1	8	9
166	R:R:A275	R:R:F222	4.16	No	Yes	0	6	8
167	R:R:F222	R:R:H278	11.31	Yes	No	1	8	7
168	R:R:F270	R:R:I226	7.54	Yes	No	0	9	6
169	R:R:M236	R:R:Y233	3.59	No	Yes	2	8	8
170	R:R:V263	R:R:Y233	8.83	No	Yes	0	7	8
171	R:R:V266	R:R:Y233	3.79	No	Yes	2	7	8
172	R:R:Y233	R:R:Y318	4.96	Yes	Yes	2	8	9
173	R:R:L240	R:R:M236	4.24	No	No	2	8	8
174	R:R:L237	R:R:T260	10.32	No	No	0	5	7
175	R:R:L237	R:R:V263	10.43	No	No	0	5	7
176	R:R:R239	R:R:S242	3.95	No	No	0	5	4
177	R:R:L240	R:R:V243	4.47	No	No	0	8	6
178	R:R:L245	R:R:V243	4.47	No	No	0	3	6
179	R:R:L245	R:R:S255	7.51	No	No	0	3	5
180	R:R:L246	R:R:S255	4.5	No	No	0	2	5
181	R:R:E251	R:R:K250	6.75	No	No	0	3	2
182	R:R:K250	R:R:R254	3.71	No	No	0	2	4
183	R:R:R257	R:R:R261	6.4	No	No	0	5	6
184	R:R:I259	R:R:R258	5.01	No	No	0	8	7
185	R:R:E323	R:R:R258	13.96	No	No	0	4	7
186	R:R:L321	R:R:M262	8.48	No	No	0	6	8
187	R:R:V266	R:R:Y318	8.83	No	Yes	2	7	9
188	R:R:F270	R:R:W274	11.02	Yes	Yes	1	9	8
189	R:R:C273	R:R:N310	6.3	No	Yes	0	8	9
190	R:R:H278	R:R:W274	8.46	No	Yes	1	7	8
191	R:R:G307	R:R:W274	5.63	No	Yes	0	7	8
192	R:R:N310	R:R:W274	12.43	Yes	Yes	0	9	8
193	R:R:C303	R:R:P276	3.77	No	No	0	6	9
194	R:R:F280	R:R:L300	8.53	No	No	0	5	5
195	R:R:I289	R:R:W284	5.87	Yes	No	4	1	4
196	R:R:R291	R:R:W284	27.99	No	No	4	1	4
197	R:R:I289	R:R:R291	3.76	Yes	No	4	1	1
198	R:R:D290	R:R:D293	5.32	No	Yes	0	3	3
199	R:R:D293	R:R:P294	6.44	Yes	No	0	3	2
200	R:R:D293	R:R:L295	5.43	Yes	No	0	3	2
201	R:R:D293	R:R:V296	5.84	Yes	No	0	3	5
202	R:R:I304	R:R:L300	7.14	Yes	No	0	5	5
203	R:R:H301	R:R:I304	3.98	Yes	Yes	1	4	5
204	R:R:N310	R:R:N314	8.17	Yes	Yes	0	9	9
205	R:R:F320	R:R:L321	3.65	No	No	0	7	6
206	R:R:D322	R:R:N324	6.73	No	No	0	8	7
207	R:R:D322	R:R:F325	19.11	No	Yes	0	8	8
208	R:R:E323	R:R:K326	9.45	No	No	0	4	8
209	R:R:N324	R:R:R327	4.82	No	No	0	7	5
210	R:R:K326	R:R:R330	6.19	No	No	0	8	5
211	R:R:C333	R:R:F329	5.59	No	No	0	5	6
212	R:R:P315	R:R:V70	3.53	No	No	0	9	8
213	R:R:P182	R:R:V181	3.53	No	No	0	7	4
214	R:R:P225	R:R:V224	3.53	No	No	0	8	5
215	R:R:P225	R:R:T140	3.5	No	No	0	8	7
216	R:R:E323	R:R:R327	3.49	No	No	0	4	5
217	R:R:A309	R:R:V59	3.39	No	No	0	5	7
218	R:R:A319	R:R:V70	3.39	No	No	0	7	8
219	R:R:C121	R:R:T189	3.38	No	No	0	9	4
220	R:R:A94	R:R:T134	3.36	No	Yes	0	8	8
221	R:R:A195	R:R:T113	3.36	No	No	0	2	4
222	R:R:L306	R:R:P276	3.28	No	No	0	7	9
223	R:R:E251	R:R:G248	3.27	No	No	0	3	2
224	R:R:C303	R:R:I277	3.27	No	No	0	6	5
225	R:R:S42	R:R:S45	3.26	No	No	0	5	6
226	R:R:A187	R:R:K122	3.21	No	No	0	4	7
227	R:R:C60	R:R:L64	3.17	No	No	0	6	6
228	R:R:T113	R:R:V196	3.17	No	No	0	4	4
229	R:R:T189	R:R:V196	3.17	No	No	0	4	4
230	R:R:A187	R:R:L125	3.15	No	No	0	4	5
231	R:R:T211	R:R:T285	3.14	No	No	0	2	4
232	R:R:I226	R:R:V271	3.07	No	No	0	6	6
233	R:R:I289	R:R:V283	3.07	Yes	No	0	1	4
234	R:R:I289	R:R:V287	3.07	Yes	No	0	1	3
235	R:R:K250	R:R:S249	3.06	No	No	0	2	2
236	R:R:I226	R:R:T230	3.04	No	No	0	6	4
237	R:R:F202	R:R:W209	3.01	Yes	No	0	6	4
238	R:R:K214	R:R:T285	3	Yes	No	0	5	4
239	R:R:L317	R:R:V265	2.98	No	No	0	8	6
240	R:R:L256	R:R:T260	2.95	No	No	0	6	7
241	R:R:L286	R:R:T285	2.95	No	No	0	4	4
242	R:R:I172	R:R:M141	2.92	No	Yes	0	6	7
243	R:R:G73	R:R:Y77	2.9	No	Yes	0	8	5
244	R:R:G180	R:R:Y130	2.9	No	Yes	0	7	5
245	R:R:F202	R:R:P203	2.89	Yes	No	0	6	6
246	R:R:P191	R:R:R190	2.88	No	Yes	0	1	3
247	R:R:K79	R:R:K81	2.87	No	No	0	5	6
248	R:R:E118	R:R:V188	2.85	No	No	0	4	4
249	R:R:I215	R:R:L219	2.85	No	No	0	4	4
250	R:R:G117	R:R:W114	2.81	No	Yes	0	7	8
251	R:R:A83	R:R:R160	2.77	No	Yes	0	5	6
252	R:R:A107	R:R:F116	2.77	No	Yes	0	3	7
253	R:R:A156	R:R:R160	2.77	No	Yes	0	5	6
254	R:R:A299	R:R:F280	2.77	No	No	0	5	5
255	R:R:L313	R:R:L317	2.77	No	No	9	7	8
256	R:R:A305	R:R:Y56	2.67	No	Yes	0	5	7
257	R:R:A176	R:R:Y130	2.67	No	Yes	0	8	5
258	R:R:E251	R:R:L246	2.65	No	No	0	3	2
259	R:R:F202	R:R:S206	2.64	Yes	No	0	6	3
260	R:R:R239	R:R:V150	2.62	No	No	0	5	8
261	R:R:H152	R:R:K155	2.62	No	No	0	6	5
262	R:R:R239	R:R:V243	2.62	No	No	0	5	6
263	R:R:F320	R:R:V316	2.62	No	No	0	7	6
264	R:R:V267	R:R:Y233	2.52	No	Yes	0	7	8
265	R:R:F220	R:R:L219	2.44	No	No	0	4	4
266	R:R:L238	R:R:R241	2.43	No	No	0	4	4
267	R:R:G180	R:R:S126	1.86	No	No	0	7	6
268	R:R:P153	R:R:V154	1.77	No	No	0	8	5
269	R:R:P162	R:R:T161	1.75	No	No	0	3	7
270	R:R:G66	R:R:L65	1.71	No	No	0	7	4
271	R:R:A98	R:R:S311	1.71	No	No	0	6	9
272	R:R:C273	R:R:V272	1.71	No	No	0	8	6
273	R:R:I86	R:R:P162	1.69	Yes	No	0	6	3
274	R:R:A163	R:R:T161	1.68	No	No	0	4	7
275	R:R:L48	R:R:P294	1.64	No	No	0	2	2
276	R:R:S42	R:R:S44	1.63	No	No	0	5	4
277	R:R:A298	R:R:I52	1.62	No	Yes	0	1	5
278	R:R:S177	R:R:V181	1.62	No	No	0	4	4
279	R:R:A275	R:R:I279	1.62	No	No	0	6	6
280	R:R:A96	R:R:M71	1.61	No	No	0	7	7
281	R:R:S57	R:R:T53	1.6	No	No	0	4	6
282	R:R:S106	R:R:T53	1.6	No	No	0	6	6
283	R:R:S100	R:R:T101	1.6	No	No	0	5	7
284	R:R:C328	R:R:L332	1.59	No	No	0	6	5
285	R:R:A49	R:R:L110	1.58	No	No	0	4	4
286	R:R:A269	R:R:L313	1.58	No	No	9	6	7
287	R:R:A269	R:R:L317	1.58	No	No	9	6	8
288	R:R:A269	R:R:N310	1.56	No	Yes	0	6	9
289	R:R:I170	R:R:V174	1.54	No	No	0	4	4
290	R:R:H152	R:R:P153	1.53	No	No	0	6	8
291	R:R:M71	R:R:V68	1.52	No	No	0	7	4
292	R:R:L227	R:R:V223	1.49	No	No	0	4	4
293	R:R:L235	R:R:V231	1.49	No	No	0	4	4
294	R:R:L321	R:R:V265	1.49	No	No	0	6	6
295	R:R:K252	R:R:L245	1.41	Yes	No	0	2	3
296	R:R:K252	R:R:L246	1.41	Yes	No	0	2	2
297	R:R:C333	R:R:R334	1.39	No	No	0	5	5
298	R:R:L302	R:R:L55	1.38	No	No	0	5	5
299	R:R:L65	R:R:L69	1.38	No	No	0	4	6
300	R:R:L235	R:R:L238	1.38	No	No	0	4	4
301	R:R:D253	R:R:K252	1.38	No	Yes	0	2	2
302	R:R:R261	R:R:V265	1.31	No	No	0	6	6
303	R:R:T78	R:R:Y77	1.25	No	Yes	0	6	5
304	R:R:K252	R:R:R244	1.24	Yes	No	0	2	4
305	R:R:F137	R:R:L175	1.22	No	No	0	6	5
306	R:R:D288	R:R:R291	1.19	No	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	8.62	6	1	0
2	L:L:?2	10.282	5	1	0
3	L:L:F4	7.41	6	3	0
4	R:R:I52	6.05	4	1	5
5	R:R:Y56	6.45333	6	1	7
6	R:R:Y77	8.67	4	0	5
7	R:R:I86	4.782	5	0	6
8	R:R:Y87	8.962	5	2	7
9	R:R:F89	5.9725	4	0	6
10	R:R:L91	7.05	5	2	9
11	R:R:D95	8.124	5	2	9
12	R:R:Q105	6.9775	4	3	5
13	R:R:W114	8.12	7	3	8
14	R:R:F116	10.384	5	0	7
15	R:R:Y130	6.2	5	6	5
16	R:R:M132	5.6225	4	1	8
17	R:R:F133	5.875	4	0	7
18	R:R:T134	8.6625	4	6	8
19	R:R:M141	6.0225	4	2	7
20	R:R:M142	5.915	4	2	9
21	R:R:Y147	6.562	5	0	8
22	R:R:R160	6.564	5	0	6
23	R:R:W173	10.5825	4	6	9
24	R:R:R190	8.2375	4	7	3
25	R:R:F202	6.32714	7	0	6
26	R:R:K214	6.91	4	0	5
27	R:R:F218	6.5925	4	1	5
28	R:R:F222	6.5475	4	1	8
29	R:R:Y233	6.12571	7	2	8
30	R:R:K252	1.36	4	0	2
31	R:R:F270	7.91	4	1	9
32	R:R:W274	8.98833	6	1	8
33	R:R:I289	3.9425	4	4	1
34	R:R:D293	5.7575	4	0	3
35	R:R:H301	10.665	4	1	4
36	R:R:I304	7.375	4	1	5
37	R:R:Y308	9.595	4	3	7
38	R:R:N310	7.115	4	0	9
39	R:R:N314	8.525	4	2	9
40	R:R:Y318	7.00167	6	2	9
41	R:R:F325	8.864	5	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	37.1518	17.89	Yes	Yes	1	0	0
2	L:L:Y1	R:R:Y129	40.2306	7.94	Yes	No	0	0	5
3	L:L:Y1	R:R:M132	89.3722	8.38	Yes	Yes	1	0	8
4	L:L:Y1	R:R:V281	11.4964	6.31	Yes	No	0	0	6
5	R:R:I183	R:R:Y129	39.5598	14.51	No	No	0	4	5
6	R:R:I183	R:R:L200	39.0232	5.71	No	No	0	4	4
7	R:R:L125	R:R:L200	34.1868	4.15	No	No	0	5	4
8	L:L:F4	R:R:L125	32.7474	15.83	Yes	No	0	0	5
9	L:L:?2	R:R:I304	34.1231	8.71	Yes	Yes	1	0	5
10	R:R:I304	R:R:Y56	24.348	9.67	Yes	Yes	1	5	7
11	R:R:L102	R:R:Y56	16.9376	5.86	No	Yes	0	7	7
12	R:R:L102	R:R:Y308	12.0035	14.07	No	Yes	0	7	7
13	L:L:F4	R:R:W114	22.0401	5.01	Yes	Yes	3	0	8
14	L:L:F4	R:R:C198	13.9135	5.59	Yes	No	3	0	9
15	R:R:A298	R:R:I52	12.1603	1.62	No	Yes	0	1	5
16	R:R:A298	R:R:L48	10.5164	4.73	No	No	0	1	2
17	R:R:M132	R:R:W274	91.9621	5.82	Yes	Yes	1	8	8
18	R:R:N310	R:R:W274	97.6648	12.43	Yes	Yes	0	9	8
19	R:R:N310	R:R:N314	100	8.17	Yes	Yes	0	9	9
20	R:R:L91	R:R:N314	47.8092	10.98	Yes	Yes	2	9	9
21	R:R:L91	R:R:Y318	50.6469	4.69	Yes	Yes	2	9	9
22	R:R:M142	R:R:Y318	61.161	9.58	Yes	Yes	2	9	9
23	R:R:I88	R:R:M142	28.1089	4.37	No	Yes	0	8	9
24	R:R:F325	R:R:I88	26.972	5.02	Yes	No	0	8	8
25	R:R:L139	R:R:N314	47.4249	6.87	No	Yes	2	8	9
26	R:R:L139	R:R:Y318	47.2476	4.69	No	Yes	2	8	9
27	R:R:M142	R:R:Y87	41.5175	5.99	Yes	Yes	2	9	7
28	R:R:N169	R:R:Y87	29.1253	9.3	No	Yes	0	7	7
29	R:R:I86	R:R:N169	10.5323	4.25	Yes	No	0	6	7
30	R:R:N169	R:R:N90	18.6248	13.62	No	No	0	7	9
31	R:R:N90	R:R:W173	17.4947	5.65	No	Yes	0	9	9
32	R:R:C121	R:R:W114	13.3677	5.22	No	Yes	3	9	8
33	R:R:C121	R:R:C198	13.0494	7.28	No	No	3	9	9
34	R:R:C121	R:R:T189	24.5617	3.38	No	No	0	9	4
35	R:R:E118	R:R:T189	17.0854	8.47	No	No	0	4	4
36	R:R:Y233	R:R:Y318	45.9015	4.96	Yes	Yes	2	8	9
37	R:R:S143	R:R:Y233	19.7458	8.9	No	Yes	0	9	8
38	R:R:C232	R:R:S143	12.6378	5.16	No	No	0	8	9
39	R:R:C232	R:R:Y147	11.5373	6.72	No	Yes	0	8	8
40	R:R:M236	R:R:Y233	27.8724	3.59	No	Yes	2	8	8
41	R:R:L240	R:R:M236	23.0678	4.24	No	No	2	8	8
42	R:R:D210	R:R:K214	10.6164	9.68	No	Yes	0	4	5
43	R:R:E118	R:R:V188	15.205	2.85	No	No	0	4	4
44	R:R:R190	R:R:V188	11.4168	17	Yes	No	7	3	4
45	R:R:H278	R:R:W274	11.1053	8.46	No	Yes	1	7	8
46	R:R:L240	R:R:V243	21.94	4.47	No	No	0	8	6
47	R:R:L245	R:R:V243	20.8713	4.47	No	No	0	3	6
48	R:R:K252	R:R:L245	11.0757	1.41	Yes	No	0	2	3
49	R:R:E251	R:R:L246	12.3559	2.65	No	No	0	3	2
50	R:R:K214	R:R:V281	10.837	7.59	Yes	No	0	5	6
51	R:R:F202	R:R:L200	10.4413	7.31	Yes	No	0	6	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:Y129	7.94	1	Yes	No	0	5	0	1
L:L:Y1	R:R:M132	8.38	1	Yes	Yes	0	8	0	1
L:L:Y1	R:R:V217	7.57	1	Yes	No	0	5	0	1
L:L:Y1	R:R:I277	3.63	1	Yes	No	0	5	0	1
L:L:Y1	R:R:V281	6.31	1	Yes	No	0	6	0	1
L:L:?2	R:R:I277	4.36	1	Yes	No	0	5	0	1
L:L:?2	R:R:I304	8.71	1	Yes	Yes	0	5	0	1
L:L:F4	R:R:Q105	5.86	3	Yes	Yes	0	5	0	1
L:L:F4	R:R:K108	6.2	3	Yes	No	0	4	0	1
L:L:F4	R:R:W114	5.01	3	Yes	Yes	0	8	0	1
L:L:F4	R:R:L125	15.83	3	Yes	No	0	5	0	1
L:L:F4	R:R:D128	5.97	3	Yes	No	0	5	0	1
L:L:F4	R:R:C198	5.59	3	Yes	No	0	9	0	1
L:L:?5	R:R:K214	7.37	0	No	Yes	0	5	0	1
L:L:?5	R:R:W284	19.83	0	No	No	0	4	0	1
R:R:H301	R:R:Y56	13.07	1	Yes	Yes	4	7	2	2
R:R:I304	R:R:Y56	9.67	1	Yes	Yes	5	7	1	2
R:R:Q105	R:R:T101	4.25	3	Yes	No	5	7	1	2
R:R:T101	R:R:Y308	4.99	3	No	Yes	7	7	2	2
R:R:D128	R:R:Q105	6.53	3	No	Yes	5	5	1	1
R:R:Q105	R:R:Y308	11.27	3	Yes	Yes	5	7	1	2
R:R:K108	R:R:W114	5.8	3	No	Yes	4	8	1	1
R:R:F116	R:R:W114	20.04	0	Yes	Yes	7	8	2	1
R:R:C121	R:R:W114	5.22	3	No	Yes	9	8	2	1
R:R:V124	R:R:W114	4.9	0	No	Yes	5	8	2	1
R:R:C198	R:R:W114	13.06	3	No	Yes	9	8	1	1
R:R:C121	R:R:C198	7.28	3	No	No	9	9	2	1
R:R:L125	R:R:L200	4.15	0	No	No	5	4	1	2
R:R:D128	R:R:Y308	8.05	3	No	Yes	5	7	1	2
R:R:I183	R:R:Y129	14.51	0	No	No	4	5	2	1
R:R:F133	R:R:M132	3.73	0	Yes	Yes	7	8	2	1
R:R:M132	R:R:V217	4.56	1	Yes	No	8	5	1	1
R:R:M132	R:R:W274	5.82	1	Yes	Yes	8	8	1	2
R:R:I183	R:R:L200	5.71	0	No	No	4	4	2	2
R:R:D210	R:R:K214	9.68	0	No	Yes	4	5	2	1
R:R:K214	R:R:V281	7.59	0	Yes	No	5	6	1	1
R:R:I289	R:R:W284	5.87	4	Yes	No	1	4	2	1
R:R:R291	R:R:W284	27.99	4	No	No	1	4	2	1
R:R:I289	R:R:R291	3.76	4	Yes	No	1	1	2	2
R:R:I304	R:R:L300	7.14	1	Yes	No	5	5	1	2
R:R:H301	R:R:I304	3.98	1	Yes	Yes	4	5	2	1
R:R:C303	R:R:I277	3.27	0	No	No	6	5	2	1
R:R:A187	R:R:L125	3.15	0	No	No	4	5	2	1
R:R:K214	R:R:T285	3	0	Yes	No	5	4	1	2
R:R:G117	R:R:W114	2.81	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9YDP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	275
Number of Links	306
Number of Hubs	41
Number of Links mediated by Hubs	163
Number of Communities	9
Number of Nodes involved in Communities	58
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	52
Number Of Links MetaPath	51
Number of Shortest Paths	70254
Length Of Smallest Path	3
Average Path Length	14.9066
Length of Longest Path	31
Minimum Path Strength	1.31
Average Path Strength	7.30765
Maximum Path Strength	23.91
Minimum Path Correlation	0.7
Average Path Correlation	0.929045
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	47.0619
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.6947
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	D-Alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


Code	DLE
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	DLE
Name	D-Leucine
Synonyms	(R)-leucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	6950207
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41143
Sequence	>9YDP_nogp_Chain_R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E T W P F G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P A K A K L I N I C I W V L A S G V G V P I M V M A V T R P R D G A V V C M L Q F P S P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V R L L S G S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D I D R R D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F K R C F R Q L C R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4EJ4	A	Peptide	Opioid	δ	Mus musculus	Naltrindole	-	-	3.4	2012-05-16	doi.org/10.1038/nature11111
	4N6H	A	Peptide	Opioid	δ	Homo sapiens	Naltrindole	Na	-	1.8	2013-12-25	doi.org/10.1038/nature12944
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	6PT2	A	Peptide	Opioid	δ	Homo sapiens	KGCHM07	-	-	2.8	2019-12-11	doi.org/10.1126/sciadv.aax9115
	6PT3	A	Peptide	Opioid	δ	Homo sapiens	DPI-287	-	-	3.3	2019-12-11	doi.org/10.1126/sciadv.aax9115
	8F7S	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-	Gi1/β1/γ2	3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7S (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-		3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8Y45	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-	Gi2/β1/γ2	3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	8Y45 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-		3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	9CGJ	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-	Gi1/β1/γ2	2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGJ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-		2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-	Gi1/β1/γ2	2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-		2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9YDP	A	Peptide	Opioid	δ	Homo sapiens	DADLE	-	chim(NtGi1L-Gs-CtGi1)/β1/γ2	1.95	2025-12-10	10.1101/2025.10.16.682975
	9YDP (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	-		1.95	2025-12-10	10.1101/2025.10.16.682975
	9YDQ	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3614	chim(NtGi1L-Gs-CtGi1)/β1/γ2	1.94	2025-12-10	10.1101/2025.10.16.682975
	9YDQ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3614		1.94	2025-12-10	10.1101/2025.10.16.682975
	9YDR	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3983	chim(NtGi1L-Gs-CtGi1)/β1/γ2	2.14	2025-12-10	10.1101/2025.10.16.682975
	9YDR (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3983		2.14	2025-12-10	10.1101/2025.10.16.682975
	8Y71	A	Peptide	Opioid	δ	Homo sapiens	A1D6F	BMS986187	Gi1/β1/γ2	2.97	2026-01-07	To be published
	8Y71 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	A1D6F	BMS986187		2.97	2026-01-07	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.