psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	16.69	Yes	Yes	0	0	0
2	L:L:Y1	R:R:Y129	6.95	Yes	No	0	0	5
3	L:L:Y1	R:R:M132	8.38	Yes	No	0	0	8
4	L:L:Y1	R:R:V217	6.31	Yes	No	0	0	5
5	L:L:Y1	R:R:V281	3.79	Yes	No	0	0	6
6	L:L:?2	L:L:G3	6.96	Yes	No	0	0	0
7	L:L:?2	L:L:?5	12.26	Yes	No	0	0	0
8	L:L:?2	R:R:I277	5.81	Yes	No	0	0	5
9	L:L:?2	R:R:I304	8.71	Yes	Yes	0	0	5
10	L:L:F4	R:R:Q105	4.68	No	Yes	0	0	5
11	L:L:F4	R:R:K108	4.96	No	No	0	0	4
12	L:L:F4	R:R:L125	14.61	No	No	0	0	5
13	L:L:?5	R:R:K214	11.05	No	Yes	0	0	5
14	L:L:?5	R:R:W284	18.84	No	No	0	0	4
15	R:R:A298	R:R:L48	4.73	No	No	0	1	2
16	R:R:I52	R:R:Y109	9.67	No	No	3	5	4
17	R:R:H301	R:R:I52	10.61	Yes	No	3	4	5
18	R:R:L110	R:R:T53	13.27	No	No	0	4	6
19	R:R:A305	R:R:L55	4.73	No	No	0	5	5
20	R:R:L102	R:R:Y56	5.86	Yes	Yes	0	7	7
21	R:R:S106	R:R:Y56	3.82	No	Yes	0	6	7
22	R:R:H301	R:R:Y56	13.07	Yes	Yes	3	4	7
23	R:R:I304	R:R:Y56	9.67	Yes	Yes	3	5	7
24	R:R:S312	R:R:V59	4.85	No	No	0	7	7
25	R:R:C60	R:R:L102	6.35	No	Yes	0	6	7
26	R:R:C60	R:R:P103	3.77	No	No	0	6	8
27	R:R:G66	R:R:P315	4.06	No	No	0	7	9
28	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
29	R:R:D95	R:R:N67	6.73	Yes	Yes	0	9	9
30	R:R:N67	R:R:P315	9.77	Yes	No	0	9	9
31	R:R:F89	R:R:M71	7.46	Yes	No	0	6	7
32	R:R:F72	R:R:R76	8.55	No	No	0	4	5
33	R:R:F89	R:R:I74	8.79	Yes	No	0	6	7
34	R:R:F325	R:R:I74	6.28	Yes	No	0	8	7
35	R:R:F89	R:R:V75	3.93	Yes	No	0	6	3
36	R:R:R76	R:R:Y77	20.58	No	Yes	0	5	5
37	R:R:L332	R:R:Y77	14.07	No	Yes	0	5	5
38	R:R:N85	R:R:T78	4.39	No	No	6	8	6
39	R:R:F325	R:R:T78	9.08	Yes	No	6	8	6
40	R:R:K79	R:R:K81	7.18	No	No	0	5	6
41	R:R:I86	R:R:M80	5.83	Yes	No	0	6	7
42	R:R:F89	R:R:M80	3.73	Yes	No	0	6	7
43	R:R:N85	R:R:T82	13.16	No	No	0	8	7
44	R:R:R160	R:R:T84	3.88	Yes	No	0	6	8
45	R:R:F325	R:R:N85	4.83	Yes	No	6	8	8
46	R:R:A165	R:R:I86	4.87	No	Yes	0	7	6
47	R:R:I86	R:R:K166	7.27	Yes	No	0	6	3
48	R:R:I86	R:R:N169	4.25	Yes	No	0	6	7
49	R:R:M141	R:R:Y87	9.58	Yes	Yes	7	7	7
50	R:R:M142	R:R:Y87	4.79	No	Yes	0	9	7
51	R:R:D145	R:R:Y87	11.49	No	Yes	0	8	7
52	R:R:A165	R:R:Y87	4	No	Yes	0	7	7
53	R:R:I168	R:R:Y87	7.25	No	Yes	7	5	7
54	R:R:N169	R:R:Y87	10.47	No	Yes	0	7	7
55	R:R:I88	R:R:M142	4.37	No	No	0	8	9
56	R:R:F325	R:R:I88	5.02	Yes	No	0	8	8
57	R:R:N169	R:R:N90	19.07	No	No	0	7	9
58	R:R:N90	R:R:W173	5.65	No	Yes	0	9	9
59	R:R:D95	R:R:L91	8.14	Yes	Yes	1	9	9
60	R:R:L91	R:R:T138	5.9	Yes	No	0	9	8
61	R:R:L139	R:R:L91	5.54	No	Yes	1	8	9
62	R:R:L91	R:R:N314	8.24	Yes	Yes	1	9	9
63	R:R:L91	R:R:Y318	4.69	Yes	Yes	1	9	9
64	R:R:L93	R:R:L97	4.15	No	No	0	6	7
65	R:R:L93	R:R:W173	6.83	No	Yes	0	6	9
66	R:R:D95	R:R:S135	7.36	Yes	No	0	9	9
67	R:R:D95	R:R:S311	10.31	Yes	No	0	9	9
68	R:R:D95	R:R:N314	8.08	Yes	Yes	1	9	9
69	R:R:L97	R:R:N131	10.98	No	Yes	0	7	8
70	R:R:Q105	R:R:T101	4.25	Yes	Yes	5	5	7
71	R:R:T101	R:R:V124	4.76	Yes	No	0	7	5
72	R:R:T101	R:R:Y308	4.99	Yes	Yes	5	7	7
73	R:R:L102	R:R:Y308	14.07	Yes	Yes	0	7	7
74	R:R:F104	R:R:F116	9.65	No	Yes	0	6	7
75	R:R:F104	R:R:V124	11.8	No	No	0	6	5
76	R:R:D128	R:R:Q105	3.92	No	Yes	5	5	5
77	R:R:Q105	R:R:Y308	11.27	Yes	Yes	5	5	7
78	R:R:K108	R:R:W114	5.8	No	Yes	0	4	8
79	R:R:H301	R:R:Y109	16.33	Yes	No	3	4	4
80	R:R:M111	R:R:P115	6.71	No	No	0	4	3
81	R:R:F116	R:R:W114	20.04	Yes	Yes	0	7	8
82	R:R:C121	R:R:W114	5.22	No	Yes	8	9	8
83	R:R:V124	R:R:W114	6.13	No	Yes	0	5	8
84	R:R:C198	R:R:W114	11.75	No	Yes	8	9	8
85	R:R:F116	R:R:P115	14.45	Yes	No	0	7	3
86	R:R:F116	R:R:L120	6.09	Yes	No	0	7	6
87	R:R:E118	R:R:T189	11.29	No	No	0	4	4
88	R:R:L119	W:W:?1	5.92	No	Yes	0	3	0
89	R:R:C121	R:R:C198	7.28	No	No	8	9	9
90	R:R:A187	R:R:K122	4.82	No	No	0	4	7
91	R:R:A123	W:W:?1	8.99	No	Yes	0	4	0
92	R:R:M184	R:R:S126	10.73	No	No	2	4	6
93	R:R:S126	W:W:?1	5.36	No	Yes	2	6	0
94	R:R:I127	R:R:N131	5.66	No	Yes	2	5	8
95	R:R:I127	W:W:?1	7.13	No	Yes	2	5	0
96	R:R:D128	R:R:Y308	9.2	No	Yes	5	5	7
97	R:R:I183	R:R:Y129	10.88	No	No	0	4	5
98	R:R:N131	R:R:Y130	4.65	Yes	Yes	2	8	5
99	R:R:T134	R:R:Y130	6.24	Yes	Yes	2	8	5
100	R:R:W173	R:R:Y130	9.65	Yes	Yes	2	9	5
101	R:R:S177	R:R:Y130	6.36	No	Yes	2	4	5
102	R:R:Y130	W:W:?1	48.5	Yes	Yes	2	5	0
103	R:R:N131	R:R:T134	4.39	Yes	Yes	2	8	8
104	R:R:N131	W:W:?1	3.92	Yes	Yes	2	8	0
105	R:R:F133	R:R:M132	3.73	Yes	No	0	7	8
106	R:R:M132	R:R:W274	5.82	No	Yes	0	8	8
107	R:R:F133	R:R:F137	5.36	Yes	No	0	7	6
108	R:R:F133	R:R:V179	10.49	Yes	No	0	7	4
109	R:R:T134	R:R:W173	16.98	Yes	Yes	2	8	9
110	R:R:F270	R:R:I136	8.79	Yes	No	1	9	7
111	R:R:I136	R:R:W274	12.92	No	Yes	1	7	8
112	R:R:L139	R:R:N314	8.24	No	Yes	1	8	9
113	R:R:L139	R:R:Y318	4.69	No	Yes	1	8	9
114	R:R:I228	R:R:T140	4.56	No	No	0	7	7
115	R:R:I229	R:R:T140	7.6	No	No	0	8	7
116	R:R:M141	R:R:V144	6.09	Yes	No	0	7	7
117	R:R:I168	R:R:M141	5.83	No	Yes	7	5	7
118	R:R:M142	R:R:Y318	7.18	No	Yes	0	9	9
119	R:R:I229	R:R:S143	7.74	No	No	0	8	9
120	R:R:S143	R:R:Y233	7.63	No	Yes	0	9	8
121	R:R:D145	R:R:R160	17.87	No	Yes	0	8	6
122	R:R:R146	R:R:Y233	9.26	No	Yes	1	9	8
123	R:R:R146	R:R:Y318	9.26	No	Yes	1	9	9
124	R:R:C151	R:R:Y147	6.72	No	Yes	0	7	8
125	R:R:H152	R:R:Y147	8.71	Yes	Yes	0	6	8
126	R:R:C232	R:R:Y147	6.72	No	Yes	0	8	8
127	R:R:L235	R:R:Y147	7.03	No	Yes	0	4	8
128	R:R:H152	R:R:I148	3.98	Yes	No	0	6	5
129	R:R:F159	R:R:I148	7.54	No	No	0	3	5
130	R:R:A149	R:R:R160	5.53	No	Yes	0	8	6
131	R:R:M236	R:R:V150	7.61	No	No	0	8	8
132	R:R:L240	R:R:V150	5.96	No	No	0	8	8
133	R:R:D158	R:R:K164	4.15	No	No	0	4	4
134	R:R:F159	R:R:I168	3.77	No	No	0	3	5
135	R:R:K164	R:R:T161	6.01	No	No	0	4	7
136	R:R:W173	W:W:?1	4.06	Yes	Yes	2	9	0
137	R:R:S177	W:W:?1	4.28	No	Yes	2	4	0
138	R:R:I183	R:R:L200	4.28	No	No	0	4	4
139	R:R:M184	W:W:?1	16.13	No	Yes	2	4	0
140	R:R:F202	R:R:M186	7.46	Yes	No	0	6	4
141	R:R:R190	R:R:V188	17	Yes	No	9	3	4
142	R:R:Q201	R:R:V188	5.73	No	No	9	4	4
143	R:R:Q201	R:R:R190	9.35	No	Yes	9	4	3
144	R:R:D193	R:R:R192	5.96	No	No	0	1	1
145	R:R:R192	R:R:V197	7.85	No	No	0	1	4
146	R:R:F202	R:R:L200	8.53	Yes	No	0	6	4
147	R:R:D210	R:R:F202	13.14	No	Yes	0	4	6
148	R:R:F202	R:R:T213	9.08	Yes	No	0	6	6
149	R:R:P205	R:R:S204	5.34	No	No	0	2	4
150	R:R:P205	R:R:W207	4.05	No	No	10	2	3
151	R:R:P205	R:R:Y208	4.17	No	No	10	2	3
152	R:R:W207	R:R:Y208	5.79	No	No	10	3	3
153	R:R:V212	R:R:Y208	7.57	No	No	0	4	3
154	R:R:D210	R:R:K214	9.68	No	Yes	0	4	5
155	R:R:K214	R:R:V281	7.59	Yes	No	0	5	6
156	R:R:C216	R:R:F220	4.19	No	No	0	3	4
157	R:R:F218	R:R:F222	7.5	Yes	No	1	5	8
158	R:R:F218	R:R:V223	7.87	Yes	No	0	5	4
159	R:R:F218	R:R:H278	6.79	Yes	Yes	1	5	7
160	R:R:F218	R:R:I282	7.54	Yes	No	0	5	6
161	R:R:L219	R:R:V223	4.47	No	No	0	4	4
162	R:R:A275	R:R:F222	4.16	No	No	0	6	8
163	R:R:F222	R:R:H278	11.31	No	Yes	1	8	7
164	R:R:F270	R:R:I226	7.54	Yes	No	0	9	6
165	R:R:V263	R:R:Y233	6.31	No	Yes	0	7	8
166	R:R:Y233	R:R:Y318	4.96	Yes	Yes	1	8	9
167	R:R:L237	R:R:T260	10.32	No	No	0	5	7
168	R:R:L237	R:R:V263	10.43	No	No	0	5	7
169	R:R:L240	R:R:V243	4.47	No	No	0	8	6
170	R:R:L245	R:R:V243	4.47	No	No	0	3	6
171	R:R:L245	R:R:S255	7.51	No	No	0	3	5
172	R:R:E251	R:R:L246	3.98	No	No	0	3	2
173	R:R:L246	R:R:S255	6.01	No	No	0	2	5
174	R:R:D253	R:R:K252	4.15	No	Yes	0	2	2
175	R:R:R257	R:R:R261	5.33	No	No	0	5	6
176	R:R:I259	R:R:R258	5.01	No	No	0	8	7
177	R:R:E323	R:R:R258	10.47	No	No	0	4	7
178	R:R:L321	R:R:M262	7.07	No	No	0	6	8
179	R:R:V266	R:R:Y318	8.83	No	Yes	0	7	9
180	R:R:F270	R:R:W274	10.02	Yes	Yes	1	9	8
181	R:R:F270	R:R:N310	4.83	Yes	Yes	1	9	9
182	R:R:C273	R:R:N310	7.87	No	Yes	0	8	9
183	R:R:H278	R:R:W274	5.29	Yes	Yes	1	7	8
184	R:R:G307	R:R:W274	7.04	No	Yes	0	7	8
185	R:R:N310	R:R:W274	13.56	Yes	Yes	1	9	8
186	R:R:C303	R:R:P276	3.77	No	No	0	6	9
187	R:R:H278	R:R:I277	3.98	Yes	No	0	7	5
188	R:R:C303	R:R:I277	4.91	No	No	0	6	5
189	R:R:F280	R:R:L300	10.96	Yes	No	0	5	5
190	R:R:C303	R:R:F280	4.19	No	Yes	0	6	5
191	R:R:I289	R:R:W284	4.7	Yes	No	4	1	4
192	R:R:R291	R:R:W284	28.99	Yes	No	4	1	4
193	R:R:I289	R:R:R291	3.76	Yes	Yes	4	1	1
194	R:R:D290	R:R:D293	5.32	No	Yes	0	3	3
195	R:R:D293	R:R:P294	8.05	Yes	No	0	3	2
196	R:R:D293	R:R:L295	4.07	Yes	No	0	3	2
197	R:R:D293	R:R:V296	5.84	Yes	No	0	3	5
198	R:R:I304	R:R:L300	4.28	Yes	No	0	5	5
199	R:R:H301	R:R:I304	3.98	Yes	Yes	3	4	5
200	R:R:N310	R:R:N314	8.17	Yes	Yes	1	9	9
201	R:R:D322	R:R:N324	6.73	No	No	0	8	7
202	R:R:D322	R:R:F325	19.11	No	Yes	0	8	8
203	R:R:E323	R:R:K326	6.75	No	No	0	4	8
204	R:R:N324	R:R:R327	4.82	No	No	0	7	5
205	R:R:K326	R:R:R330	8.66	No	No	0	8	5
206	R:R:C333	R:R:F329	8.38	No	No	0	5	6
207	R:R:M199	R:R:R190	3.72	No	Yes	0	4	3
208	R:R:M199	R:R:R192	3.72	No	No	0	4	1
209	R:R:G63	R:R:S312	3.71	No	No	0	8	7
210	R:R:V212	R:R:W209	3.68	No	No	0	4	4
211	R:R:F137	R:R:L175	3.65	No	No	0	6	5
212	R:R:F320	R:R:L321	3.65	No	No	0	7	6
213	R:R:M236	R:R:Y233	3.59	No	Yes	0	8	8
214	R:R:P315	R:R:V70	3.53	No	No	0	9	8
215	R:R:P182	R:R:V181	3.53	No	No	0	7	4
216	R:R:P225	R:R:V224	3.53	No	No	0	8	5
217	R:R:P225	R:R:T140	3.5	No	No	0	8	7
218	R:R:E323	R:R:R327	3.49	No	No	0	4	5
219	R:R:A319	R:R:V70	3.39	No	No	0	7	8
220	R:R:C121	R:R:T189	3.38	No	No	0	9	4
221	R:R:A94	R:R:T134	3.36	No	Yes	0	8	8
222	R:R:A195	R:R:T113	3.36	No	No	0	2	4
223	R:R:M186	R:R:P203	3.35	No	No	0	4	6
224	R:R:L306	R:R:P276	3.28	No	No	0	7	9
225	R:R:S42	R:R:S45	3.26	No	No	0	5	6
226	R:R:V283	R:R:V287	3.21	No	No	4	4	3
227	R:R:C60	R:R:L64	3.17	No	No	0	6	6
228	R:R:T113	R:R:V196	3.17	No	No	0	4	4
229	R:R:T189	R:R:V196	3.17	No	No	0	4	4
230	R:R:A269	R:R:L317	3.15	No	Yes	0	6	8
231	R:R:T211	R:R:T285	3.14	No	No	0	2	4
232	R:R:A96	R:R:N67	3.13	No	Yes	0	7	9
233	R:R:I226	R:R:V271	3.07	No	No	0	6	6
234	R:R:I289	R:R:V283	3.07	Yes	No	4	1	4
235	R:R:I289	R:R:V287	3.07	Yes	No	4	1	3
236	R:R:K250	R:R:S249	3.06	No	No	0	2	2
237	R:R:I226	R:R:T230	3.04	No	No	0	6	4
238	R:R:K122	W:W:?1	3.02	No	Yes	0	7	0
239	R:R:F202	R:R:W209	3.01	Yes	No	0	6	4
240	R:R:K214	R:R:T285	3	Yes	No	0	5	4
241	R:R:L102	R:R:V59	2.98	Yes	No	0	7	7
242	R:R:L64	R:R:T99	2.95	No	No	0	6	6
243	R:R:L256	R:R:T260	2.95	No	No	0	6	7
244	R:R:L286	R:R:T285	2.95	No	No	0	4	4
245	R:R:I172	R:R:M141	2.92	No	Yes	0	6	7
246	R:R:G180	R:R:Y130	2.9	No	Yes	0	7	5
247	R:R:P191	R:R:R190	2.88	No	Yes	0	1	3
248	R:R:E118	R:R:V188	2.85	No	No	0	4	4
249	R:R:I215	R:R:L219	2.85	No	No	0	4	4
250	R:R:G117	R:R:W114	2.81	No	Yes	0	7	8
251	R:R:C151	R:R:R239	2.79	No	No	0	7	5
252	R:R:A83	R:R:R160	2.77	No	Yes	0	5	6
253	R:R:A107	R:R:F116	2.77	No	Yes	0	3	7
254	R:R:A221	R:R:F133	2.77	No	Yes	0	6	7
255	R:R:A156	R:R:R160	2.77	No	Yes	0	5	6
256	R:R:A299	R:R:F280	2.77	No	Yes	0	5	5
257	R:R:H301	R:R:V297	2.77	Yes	No	0	4	4
258	R:R:L313	R:R:L317	2.77	No	Yes	0	7	8
259	R:R:A305	R:R:Y56	2.67	No	Yes	0	5	7
260	R:R:A98	R:R:Y308	2.67	No	Yes	0	6	7
261	R:R:A176	R:R:Y130	2.67	No	Yes	0	8	5
262	R:R:F202	R:R:S206	2.64	Yes	No	0	6	3
263	R:R:R239	R:R:S242	2.64	No	No	0	5	4
264	R:R:F280	R:R:V296	2.62	Yes	No	0	5	5
265	R:R:F320	R:R:V316	2.62	No	No	0	7	6
266	R:R:V267	R:R:Y233	2.52	No	Yes	0	7	8
267	R:R:F220	R:R:L219	2.44	No	No	0	4	4
268	R:R:L238	R:R:R241	2.43	No	No	0	4	4
269	R:R:G268	R:R:V271	1.84	No	No	0	5	6
270	R:R:A309	R:R:C273	1.81	No	No	0	5	8
271	R:R:P153	R:R:V154	1.77	No	No	0	8	5
272	R:R:P162	R:R:T161	1.75	No	No	0	3	7
273	R:R:G66	R:R:L65	1.71	No	No	0	7	4
274	R:R:G66	R:R:L69	1.71	No	No	0	7	6
275	R:R:C273	R:R:V272	1.71	No	No	0	8	6
276	R:R:I86	R:R:P162	1.69	Yes	No	0	6	3
277	R:R:L48	R:R:P294	1.64	No	No	0	2	2
278	R:R:E251	R:R:G248	1.64	No	No	0	3	2
279	R:R:S42	R:R:S44	1.63	No	No	0	5	4
280	R:R:S312	R:R:V62	1.62	No	No	0	7	4
281	R:R:A275	R:R:I279	1.62	No	No	0	6	6
282	R:R:S57	R:R:T53	1.6	No	No	0	4	6
283	R:R:S106	R:R:T53	1.6	No	No	0	6	6
284	R:R:S100	R:R:T101	1.6	No	Yes	0	5	7
285	R:R:V181	R:R:V185	1.6	No	No	0	4	4
286	R:R:C328	R:R:L332	1.59	No	No	0	6	5
287	R:R:I170	R:R:V174	1.54	No	No	0	4	4
288	R:R:H152	R:R:P153	1.53	Yes	No	0	6	8
289	R:R:M71	R:R:V68	1.52	No	No	0	7	4
290	R:R:L227	R:R:V223	1.49	No	No	0	4	4
291	R:R:L235	R:R:V231	1.49	No	No	0	4	4
292	R:R:L317	R:R:V265	1.49	Yes	No	0	8	6
293	R:R:L317	R:R:V266	1.49	Yes	No	0	8	7
294	R:R:L264	R:R:T260	1.47	No	No	0	5	7
295	R:R:G73	R:R:Y77	1.45	No	Yes	0	8	5
296	R:R:I50	R:R:L46	1.43	No	No	0	5	2
297	R:R:K252	R:R:L245	1.41	Yes	No	0	2	3
298	R:R:K252	R:R:L246	1.41	Yes	No	0	2	2
299	R:R:K252	R:R:L256	1.41	Yes	No	0	2	6
300	R:R:L302	R:R:L55	1.38	No	No	0	5	5
301	R:R:L235	R:R:L238	1.38	No	No	0	4	4
302	R:R:E251	R:R:K250	1.35	No	No	0	3	2
303	R:R:A49	R:R:Y109	1.33	No	No	0	4	4
304	R:R:H152	R:R:K155	1.31	Yes	No	0	6	5
305	R:R:R261	R:R:V265	1.31	No	No	0	6	6
306	R:R:T78	R:R:Y77	1.25	No	Yes	0	6	5
307	R:R:K250	R:R:R254	1.24	No	No	0	2	4
308	R:R:M262	R:R:R258	1.24	No	No	0	8	7
309	R:R:D288	R:R:R291	1.19	No	Yes	0	3	1
310	R:R:R291	R:R:R292	1.07	Yes	No	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	8.424	5	0	0
2	L:L:?2	10.086	5	0	0
3	R:R:Y56	7.018	5	3	7
4	R:R:N67	6.08	4	0	9
5	R:R:Y77	9.3375	4	0	5
6	R:R:I86	4.782	5	0	6
7	R:R:Y87	7.93	6	7	7
8	R:R:F89	5.9775	4	0	6
9	R:R:L91	6.502	5	1	9
10	R:R:D95	8.124	5	1	9
11	R:R:T101	3.9	4	5	7
12	R:R:L102	7.315	4	0	7
13	R:R:Q105	6.03	4	5	5
14	R:R:W114	8.625	6	8	8
15	R:R:F116	10.6	5	0	7
16	R:R:Y130	11.5671	7	2	5
17	R:R:N131	5.92	5	2	8
18	R:R:F133	5.5875	4	0	7
19	R:R:T134	7.7425	4	2	8
20	R:R:M141	6.105	4	7	7
21	R:R:Y147	7.295	4	0	8
22	R:R:H152	3.8825	4	0	6
23	R:R:R160	6.564	5	0	6
24	R:R:W173	8.634	5	2	9
25	R:R:R190	8.2375	4	9	3
26	R:R:F202	7.31	6	0	6
27	R:R:K214	7.83	4	0	5
28	R:R:F218	7.425	4	1	5
29	R:R:Y233	5.71167	6	1	8
30	R:R:K252	2.095	4	0	2
31	R:R:F270	7.795	4	1	9
32	R:R:W274	9.10833	6	1	8
33	R:R:H278	6.8425	4	1	7
34	R:R:F280	5.135	4	0	5
35	R:R:I289	3.65	4	4	1
36	R:R:R291	8.7525	4	4	1
37	R:R:D293	5.82	4	0	3
38	R:R:H301	9.352	5	3	4
39	R:R:I304	6.66	4	3	5
40	R:R:Y308	8.44	5	5	7
41	R:R:N310	8.6075	4	1	9
42	R:R:N314	8.1825	4	1	9
43	R:R:L317	2.225	4	0	8
44	R:R:Y318	6.60167	6	1	9
45	R:R:F325	8.864	5	6	8
46	W:W:?1	10.731	10	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	35.7493	16.69	Yes	Yes	0	0	0
2	L:L:Y1	R:R:M132	50.7465	8.38	Yes	No	0	0	8
3	L:L:?2	R:R:I304	64.367	8.71	Yes	Yes	0	0	5
4	R:R:I304	R:R:Y56	58.0807	9.67	Yes	Yes	3	5	7
5	R:R:L102	R:R:Y56	50.5821	5.86	Yes	Yes	0	7	7
6	R:R:L102	R:R:Y308	41.3894	14.07	Yes	Yes	0	7	7
7	L:L:?2	L:L:?5	11.4066	12.26	Yes	No	0	0	0
8	L:L:?2	R:R:I277	36.8986	5.81	Yes	No	0	0	5
9	R:R:M132	R:R:W274	52.5801	5.82	No	Yes	0	8	8
10	R:R:N310	R:R:W274	96.8577	13.56	Yes	Yes	1	9	8
11	R:R:N310	R:R:N314	100	8.17	Yes	Yes	1	9	9
12	R:R:H278	R:R:I277	42.6185	3.98	Yes	No	0	7	5
13	R:R:H278	R:R:W274	46.4051	5.29	Yes	Yes	1	7	8
14	R:R:L91	R:R:N314	48.0045	8.24	Yes	Yes	1	9	9
15	R:R:L91	R:R:Y318	50.2632	4.69	Yes	Yes	1	9	9
16	R:R:M142	R:R:Y318	75.9197	7.18	No	Yes	0	9	9
17	R:R:I88	R:R:M142	24.7596	4.37	No	No	0	8	9
18	R:R:F325	R:R:I88	23.8694	5.02	Yes	No	0	8	8
19	R:R:L139	R:R:N314	47.6541	8.24	No	Yes	1	8	9
20	R:R:L139	R:R:Y318	47.478	4.69	No	Yes	1	8	9
21	R:R:M142	R:R:Y87	54.3771	4.79	No	Yes	0	9	7
22	R:R:N169	R:R:Y87	27.0382	10.47	No	Yes	0	7	7
23	R:R:I168	R:R:Y87	14.9939	7.25	No	Yes	7	5	7
24	R:R:N169	R:R:N90	20.4498	19.07	No	No	0	7	9
25	R:R:N90	R:R:W173	19.5512	5.65	No	Yes	0	9	9
26	R:R:T101	R:R:Y308	34.0469	4.99	Yes	Yes	5	7	7
27	R:R:T101	R:R:V124	32.0407	4.76	Yes	No	0	7	5
28	R:R:V124	R:R:W114	24.3278	6.13	No	Yes	0	5	8
29	R:R:C121	R:R:W114	15.9024	5.22	No	Yes	8	9	8
30	R:R:C121	R:R:T189	14.8096	3.38	No	No	0	9	4
31	R:R:E118	R:R:T189	10.3121	11.29	No	No	0	4	4
32	R:R:Y233	R:R:Y318	24.9954	4.96	Yes	Yes	1	8	9
33	R:R:F159	R:R:I168	14.2266	3.77	No	No	0	3	5
34	R:R:F159	R:R:I148	13.3896	7.54	No	No	0	3	5
35	R:R:H152	R:R:I148	12.4479	3.98	Yes	No	0	6	5
36	R:R:V263	R:R:Y233	12.2453	6.31	No	Yes	0	7	8
37	R:R:L237	R:R:V263	11.3135	10.43	No	No	0	5	7
38	R:R:L237	R:R:T260	10.3818	10.32	No	No	0	5	7
39	R:R:D322	R:R:F325	11.2787	19.11	No	Yes	0	8	8
40	R:R:D322	R:R:N324	10.3486	6.73	No	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:Y129	6.95	0	Yes	No	0	5	0	1
L:L:Y1	R:R:M132	8.38	0	Yes	No	0	8	0	1
L:L:Y1	R:R:V217	6.31	0	Yes	No	0	5	0	1
L:L:Y1	R:R:V281	3.79	0	Yes	No	0	6	0	1
L:L:?2	R:R:I277	5.81	0	Yes	No	0	5	0	1
L:L:?2	R:R:I304	8.71	0	Yes	Yes	0	5	0	1
L:L:F4	R:R:Q105	4.68	0	No	Yes	0	5	0	1
L:L:F4	R:R:K108	4.96	0	No	No	0	4	0	1
L:L:F4	R:R:L125	14.61	0	No	No	0	5	0	1
L:L:?5	R:R:K214	11.05	0	No	Yes	0	5	0	1
L:L:?5	R:R:W284	18.84	0	No	No	0	4	0	1
R:R:H301	R:R:Y56	13.07	3	Yes	Yes	4	7	2	2
R:R:I304	R:R:Y56	9.67	3	Yes	Yes	5	7	1	2
R:R:Q105	R:R:T101	4.25	5	Yes	Yes	5	7	1	2
R:R:T101	R:R:Y308	4.99	5	Yes	Yes	7	7	2	2
R:R:D128	R:R:Q105	3.92	5	No	Yes	5	5	2	1
R:R:Q105	R:R:Y308	11.27	5	Yes	Yes	5	7	1	2
R:R:K108	R:R:W114	5.8	0	No	Yes	4	8	1	2
R:R:D128	R:R:Y308	9.2	5	No	Yes	5	7	2	2
R:R:I183	R:R:Y129	10.88	0	No	No	4	5	2	1
R:R:F133	R:R:M132	3.73	0	Yes	No	7	8	2	1
R:R:M132	R:R:W274	5.82	0	No	Yes	8	8	1	2
R:R:D210	R:R:K214	9.68	0	No	Yes	4	5	2	1
R:R:K214	R:R:V281	7.59	0	Yes	No	5	6	1	1
R:R:H278	R:R:W274	5.29	1	Yes	Yes	7	8	2	2
R:R:H278	R:R:I277	3.98	1	Yes	No	7	5	2	1
R:R:C303	R:R:I277	4.91	0	No	No	6	5	2	1
R:R:I289	R:R:W284	4.7	4	Yes	No	1	4	2	1
R:R:R291	R:R:W284	28.99	4	Yes	No	1	4	2	1
R:R:I289	R:R:R291	3.76	4	Yes	Yes	1	1	2	2
R:R:I304	R:R:L300	4.28	3	Yes	No	5	5	1	2
R:R:H301	R:R:I304	3.98	3	Yes	Yes	4	5	2	1
R:R:K214	R:R:T285	3	0	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N90	R:R:W173	5.65	0	No	Yes	9	9	2	1
R:R:L93	R:R:L97	4.15	0	No	No	6	7	2	2
R:R:L93	R:R:W173	6.83	0	No	Yes	6	9	2	1
R:R:L97	R:R:N131	10.98	0	No	Yes	7	8	2	1
R:R:L119	W:W:?1	5.92	0	No	Yes	3	0	1	0
R:R:A187	R:R:K122	4.82	0	No	No	4	7	2	1
R:R:A123	W:W:?1	8.99	0	No	Yes	4	0	1	0
R:R:M184	R:R:S126	10.73	2	No	No	4	6	1	1
R:R:S126	W:W:?1	5.36	2	No	Yes	6	0	1	0
R:R:I127	R:R:N131	5.66	2	No	Yes	5	8	1	1
R:R:I127	W:W:?1	7.13	2	No	Yes	5	0	1	0
R:R:N131	R:R:Y130	4.65	2	Yes	Yes	8	5	1	1
R:R:T134	R:R:Y130	6.24	2	Yes	Yes	8	5	2	1
R:R:W173	R:R:Y130	9.65	2	Yes	Yes	9	5	1	1
R:R:S177	R:R:Y130	6.36	2	No	Yes	4	5	1	1
R:R:Y130	W:W:?1	48.5	2	Yes	Yes	5	0	1	0
R:R:N131	R:R:T134	4.39	2	Yes	Yes	8	8	1	2
R:R:N131	W:W:?1	3.92	2	Yes	Yes	8	0	1	0
R:R:T134	R:R:W173	16.98	2	Yes	Yes	8	9	2	1
R:R:W173	W:W:?1	4.06	2	Yes	Yes	9	0	1	0
R:R:S177	W:W:?1	4.28	2	No	Yes	4	0	1	0
R:R:M184	W:W:?1	16.13	2	No	Yes	4	0	1	0
R:R:K122	W:W:?1	3.02	0	No	Yes	7	0	1	0
R:R:G180	R:R:Y130	2.9	0	No	Yes	7	5	2	1
R:R:A176	R:R:Y130	2.67	0	No	Yes	8	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9YDQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.73
Number of Linked Nodes	281
Number of Links	310
Number of Hubs	46
Number of Links mediated by Hubs	184
Number of Communities	10
Number of Nodes involved in Communities	52
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	41
Number Of Links MetaPath	40
Number of Shortest Paths	81102
Length Of Smallest Path	3
Average Path Length	16.1032
Length of Longest Path	35
Minimum Path Strength	1.13
Average Path Strength	7.38638
Maximum Path Strength	32.315
Minimum Path Correlation	0.7
Average Path Correlation	0.924455
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	43.478
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	55.2795
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	D-Alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


Code	DLE
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	DLE
Name	D-Leucine
Synonyms	(R)-leucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	6950207
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	_W_
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41143
Sequence	>9YDQ_nogp_Chain_R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E T W P F G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P A K A K L I N I C I W V L A S G V G V P I M V M A V T R P R D G A V V C M L Q F P S P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V R L L S G S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D I D R R D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F K R C F R Q L C R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4EJ4	A	Peptide	Opioid	δ	Mus musculus	Naltrindole	-	-	3.4	2012-05-16	doi.org/10.1038/nature11111
	4N6H	A	Peptide	Opioid	δ	Homo sapiens	Naltrindole	Na	-	1.8	2013-12-25	doi.org/10.1038/nature12944
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	6PT2	A	Peptide	Opioid	δ	Homo sapiens	KGCHM07	-	-	2.8	2019-12-11	doi.org/10.1126/sciadv.aax9115
	6PT3	A	Peptide	Opioid	δ	Homo sapiens	DPI-287	-	-	3.3	2019-12-11	doi.org/10.1126/sciadv.aax9115
	8F7S	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-	Gi1/β1/γ2	3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7S (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-		3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8Y45	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-	Gi2/β1/γ2	3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	8Y45 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-		3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	9CGJ	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-	Gi1/β1/γ2	2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGJ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-		2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-	Gi1/β1/γ2	2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-		2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9YDP	A	Peptide	Opioid	δ	Homo sapiens	DADLE	-	chim(NtGi1L-Gs-CtGi1)/β1/γ2	1.95	2025-12-10	10.1101/2025.10.16.682975
	9YDP (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	-		1.95	2025-12-10	10.1101/2025.10.16.682975
	9YDQ	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3614	chim(NtGi1L-Gs-CtGi1)/β1/γ2	1.94	2025-12-10	10.1101/2025.10.16.682975
	9YDQ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3614		1.94	2025-12-10	10.1101/2025.10.16.682975
	9YDR	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3983	chim(NtGi1L-Gs-CtGi1)/β1/γ2	2.14	2025-12-10	10.1101/2025.10.16.682975
	9YDR (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3983		2.14	2025-12-10	10.1101/2025.10.16.682975
	8Y71	A	Peptide	Opioid	δ	Homo sapiens	A1D6F	BMS986187	Gi1/β1/γ2	2.97	2026-01-07	To be published
	8Y71 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	A1D6F	BMS986187		2.97	2026-01-07	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9YDQ_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.