psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N219	6.29	Yes	Yes	2	0	7
2	L:L:?1	R:R:M230	4.32	Yes	Yes	0	0	7
3	L:L:?1	R:R:W281	7.53	Yes	Yes	2	0	7
4	L:L:?1	R:R:D384	7.6	Yes	Yes	2	0	8
5	L:L:?1	R:R:S387	4.58	Yes	No	2	0	8
6	L:L:?1	R:R:F391	4.96	Yes	Yes	2	0	8
7	L:L:?1	R:R:Y394	11.93	Yes	Yes	2	0	5
8	L:L:?1	R:R:K395	4.31	Yes	No	0	0	3
9	L:L:?1	R:R:R400	8.04	Yes	No	0	0	9
10	L:L:?1	R:R:Q477	8.81	Yes	Yes	2	0	6
11	L:L:?1	R:R:F484	13.02	Yes	Yes	0	0	6
12	L:L:?1	R:R:P513	11.7	Yes	No	0	0	8
13	L:L:?1	R:R:E518	25.62	Yes	No	0	0	7
14	L:L:?1	R:R:N521	5.59	Yes	Yes	0	0	8
15	L:L:?1	R:R:L522	5.63	Yes	No	2	0	7
16	M:M:?1	S:S:N219	6.99	Yes	Yes	1	0	7
17	M:M:?1	S:S:W281	8.69	Yes	Yes	1	0	7
18	M:M:?1	S:S:D384	7.6	Yes	Yes	1	0	8
19	M:M:?1	S:S:S387	4.58	Yes	Yes	1	0	8
20	M:M:?1	S:S:F391	5.58	Yes	Yes	1	0	8
21	M:M:?1	S:S:Y394	11.93	Yes	Yes	1	0	5
22	M:M:?1	S:S:R400	8.65	Yes	No	0	0	9
23	M:M:?1	S:S:Q477	7.45	Yes	Yes	1	0	6
24	M:M:?1	S:S:F484	18.59	Yes	Yes	0	0	6
25	M:M:?1	S:S:P513	12.53	Yes	No	0	0	8
26	M:M:?1	S:S:E518	28.32	Yes	No	0	0	7
27	M:M:?1	S:S:N521	4.89	Yes	Yes	0	0	8
28	M:M:?1	S:S:L522	5.63	Yes	No	1	0	7
29	R:R:Q192	R:R:R199	15.19	No	No	0	4	4
30	R:R:C193	R:R:C213	7.28	No	No	0	9	9
31	R:R:P196	R:R:Q216	6.32	Yes	No	0	7	7
32	R:R:P196	R:R:P220	7.79	Yes	No	0	7	8
33	R:R:P196	R:R:Y487	6.95	Yes	No	0	7	4
34	R:R:L197	R:R:Y207	4.69	Yes	Yes	7	9	7
35	R:R:L197	R:R:V210	4.47	Yes	No	0	9	5
36	R:R:C213	R:R:L197	4.76	No	Yes	0	9	9
37	R:R:L197	R:R:V488	4.47	Yes	No	7	9	6
38	R:R:D201	R:R:R199	5.96	No	No	0	5	4
39	R:R:G212	R:R:R199	4.5	No	No	0	7	4
40	R:R:S205	R:R:T200	6.4	Yes	No	3	7	6
41	R:R:D298	R:R:T200	11.56	Yes	No	3	7	6
42	R:R:N202	R:R:P203	4.89	Yes	No	0	5	4
43	R:R:K204	R:R:N202	4.2	No	Yes	0	3	5
44	R:R:N202	R:R:S205	8.94	Yes	Yes	3	5	7
45	R:R:D298	R:R:N202	8.08	Yes	Yes	3	7	5
46	R:R:P203	R:R:W206	12.16	No	No	0	4	4
47	R:R:K204	R:R:R296	6.19	No	Yes	0	3	6
48	R:R:R296	R:R:S205	6.59	Yes	Yes	3	6	7
49	R:R:D298	R:R:S205	8.83	Yes	Yes	3	7	7
50	R:R:S205	R:R:T300	9.59	Yes	Yes	3	7	7
51	R:R:E211	R:R:W206	6.54	No	No	0	5	4
52	R:R:G212	R:R:W206	8.44	No	No	0	7	4
53	R:R:E208	R:R:Y207	12.35	No	Yes	7	4	7
54	R:R:R485	R:R:Y207	4.12	No	Yes	7	5	7
55	R:R:V488	R:R:Y207	8.83	No	Yes	7	6	7
56	R:R:E208	R:R:R485	17.45	No	No	7	4	5
57	R:R:E208	R:R:L489	3.98	No	No	7	4	4
58	R:R:I215	R:R:M301	5.83	No	No	0	5	4
59	R:R:F484	R:R:I215	5.02	Yes	No	0	6	5
60	R:R:C217	R:R:C295	7.28	No	No	0	9	9
61	R:R:E224	R:R:Q218	5.1	No	No	0	4	5
62	R:R:H227	R:R:Q218	21.02	Yes	No	2	7	5
63	R:R:Q218	R:R:S385	4.33	No	No	2	5	7
64	R:R:N219	R:R:P220	6.52	Yes	No	0	7	8
65	R:R:L221	R:R:N219	5.49	Yes	Yes	2	6	7
66	R:R:F222	R:R:N219	8.46	Yes	Yes	2	6	7
67	R:R:D384	R:R:N219	5.39	Yes	Yes	2	8	7
68	R:R:N219	R:R:V386	4.43	Yes	Yes	2	7	5
69	R:R:F484	R:R:P220	7.22	Yes	No	0	6	8
70	R:R:F222	R:R:L221	4.87	Yes	Yes	2	6	6
71	R:R:F484	R:R:L221	4.87	Yes	Yes	0	6	6
72	R:R:I509	R:R:L221	4.28	No	Yes	0	4	6
73	R:R:E226	R:R:F222	5.83	No	Yes	2	8	6
74	R:R:F222	R:R:V386	5.24	Yes	Yes	2	6	5
75	R:R:F222	R:R:R512	13.9	Yes	No	2	6	6
76	R:R:F222	R:R:P513	8.67	Yes	No	0	6	8
77	R:R:F222	R:R:L515	13.4	Yes	No	0	6	5
78	R:R:E226	R:R:T223	14.11	No	No	0	8	5
79	R:R:E224	R:R:Q228	6.37	No	No	0	4	3
80	R:R:E226	R:R:R512	10.47	No	No	2	8	6
81	R:R:H227	R:R:H231	7.17	Yes	No	0	7	7
82	R:R:H227	R:R:S385	6.97	Yes	No	2	7	7
83	R:R:H227	R:R:V386	9.69	Yes	Yes	2	7	5
84	R:R:D229	R:R:K519	6.91	No	No	0	6	7
85	R:R:I234	R:R:M230	5.83	No	Yes	0	7	7
86	R:R:L515	R:R:M230	5.65	No	Yes	0	5	7
87	R:R:K519	R:R:M230	4.32	No	Yes	0	7	7
88	R:R:H231	R:R:R290	28.21	No	No	0	7	9
89	R:R:F237	R:R:Y233	14.44	No	No	0	4	6
90	R:R:K519	R:R:Y233	26.27	No	No	0	7	6
91	R:R:I234	R:R:W281	5.87	No	Yes	0	7	7
92	R:R:F285	R:R:I234	5.02	No	No	0	8	7
93	R:R:A235	R:R:F285	6.93	No	No	0	5	8
94	R:R:F237	R:R:F523	4.29	No	No	0	4	6
95	R:R:F237	R:R:F526	9.65	No	Yes	0	4	9
96	R:R:G238	R:R:L282	5.13	No	No	0	7	7
97	R:R:F526	R:R:G238	4.52	Yes	No	0	9	7
98	R:R:F526	R:R:T241	10.38	Yes	No	0	9	7
99	R:R:I530	R:R:T241	6.08	No	No	0	7	7
100	R:R:C244	R:R:S533	5.16	No	No	0	6	9
101	R:R:N271	R:R:T245	5.85	No	No	0	9	8
102	R:R:F275	R:R:T245	5.19	Yes	No	0	5	8
103	R:R:F275	R:R:L246	7.31	Yes	No	0	5	6
104	R:R:F247	R:R:T251	7.78	No	Yes	9	8	9
105	R:R:F247	R:R:V536	3.93	No	Yes	9	8	8
106	R:R:F247	R:R:W545	6.01	No	Yes	9	8	9
107	R:R:N271	R:R:T248	11.7	No	No	0	9	8
108	R:R:S533	R:R:T248	4.8	No	No	0	9	8
109	R:R:T248	R:R:V536	11.11	No	Yes	0	8	8
110	R:R:F268	R:R:L249	4.87	Yes	No	0	8	6
111	R:R:T251	R:R:V536	11.11	Yes	Yes	9	9	8
112	R:R:T251	R:R:T541	7.85	Yes	No	9	9	8
113	R:R:T251	R:R:W545	9.7	Yes	Yes	9	9	9
114	R:R:F252	R:R:S259	5.28	No	No	0	9	8
115	R:R:F252	R:R:F268	17.15	No	Yes	0	9	8
116	R:R:D255	R:R:N258	8.08	No	No	0	8	8
117	R:R:D255	R:R:S259	7.36	No	No	0	8	8
118	R:R:D255	R:R:I544	9.8	No	No	0	8	6
119	R:R:N260	R:R:W256	22.6	No	No	0	7	7
120	R:R:F268	R:R:W256	10.02	Yes	No	0	8	7
121	R:R:N260	R:R:V265	7.39	No	No	0	7	8
122	R:R:V265	R:R:Y262	8.83	No	Yes	0	8	9
123	R:R:I266	R:R:Y262	4.84	No	Yes	0	8	9
124	R:R:G355	R:R:Y262	4.35	No	Yes	0	6	9
125	R:R:F360	R:R:Y262	7.22	Yes	Yes	0	9	9
126	R:R:L452	R:R:P263	4.93	No	No	0	8	9
127	R:R:V265	R:R:Y269	3.79	No	Yes	0	8	8
128	R:R:I266	R:R:W331	7.05	No	Yes	6	8	9
129	R:R:I266	R:R:V334	4.61	No	No	6	8	7
130	R:R:L267	R:R:L335	4.15	No	No	0	8	8
131	R:R:L267	R:R:M532	4.24	No	Yes	0	8	8
132	R:R:L267	R:R:W535	17.08	No	Yes	0	8	9
133	R:R:F268	R:R:Y269	9.28	Yes	Yes	0	8	8
134	R:R:W331	R:R:Y269	18.33	Yes	Yes	6	9	8
135	R:R:H361	R:R:Y269	9.8	No	Yes	6	9	8
136	R:R:W365	R:R:Y269	3.86	Yes	Yes	6	9	8
137	R:R:C273	R:R:G328	3.92	No	No	0	9	8
138	R:R:F274	R:R:T528	7.78	No	No	0	9	7
139	R:R:F274	R:R:G529	9.03	No	No	0	9	9
140	R:R:F275	R:R:I279	6.28	Yes	No	0	5	5
141	R:R:V321	R:R:W281	8.58	No	Yes	2	8	7
142	R:R:I389	R:R:W281	12.92	No	Yes	2	9	7
143	R:R:L522	R:R:W281	5.69	No	Yes	2	7	7
144	R:R:F526	R:R:W281	8.02	Yes	Yes	2	9	7
145	R:R:F285	R:R:Q284	17.57	No	No	0	8	9
146	R:R:Q284	R:R:R290	17.52	No	No	10	9	9
147	R:R:G388	R:R:Q284	8.22	No	No	10	9	9
148	R:R:G388	R:R:R290	4.5	No	No	10	9	9
149	R:R:E292	R:R:T311	11.29	No	No	3	5	7
150	R:R:E292	R:R:S313	10.06	No	No	3	5	7
151	R:R:I293	R:R:I317	8.83	No	No	0	8	7
152	R:R:G383	R:R:V294	5.52	No	No	0	8	8
153	R:R:D298	R:R:R296	4.76	Yes	Yes	3	7	6
154	R:R:R296	R:R:T300	3.88	Yes	Yes	3	6	7
155	R:R:R296	R:R:T307	6.47	Yes	No	3	6	6
156	R:R:E310	R:R:R296	10.47	Yes	Yes	3	8	6
157	R:R:D298	R:R:T300	13.01	Yes	Yes	3	7	7
158	R:R:L303	R:R:M301	7.07	No	No	0	3	4
159	R:R:E305	R:R:R302	12.79	No	Yes	3	7	6
160	R:R:E310	R:R:R302	4.65	Yes	Yes	3	8	6
161	R:R:R302	R:R:T311	5.17	Yes	No	3	6	7
162	R:R:C314	R:R:R302	11.14	No	Yes	3	9	6
163	R:R:D382	R:R:L303	5.43	No	No	0	9	3
164	R:R:E305	R:R:T307	11.29	No	No	3	7	6
165	R:R:C314	R:R:E305	10.64	No	No	3	9	7
166	R:R:P306	R:R:V315	5.3	No	No	0	5	7
167	R:R:L376	R:R:P306	6.57	No	No	0	8	5
168	R:R:E310	R:R:T307	4.23	Yes	No	3	8	6
169	R:R:N309	R:R:S308	4.47	No	No	0	6	8
170	R:R:S313	R:R:T311	6.4	No	No	3	7	7
171	R:R:C314	R:R:C390	7.28	No	No	0	9	9
172	R:R:F318	R:R:Y322	9.28	Yes	Yes	2	9	9
173	R:R:F318	R:R:I375	10.05	Yes	Yes	2	9	7
174	R:R:F318	R:R:V381	15.73	Yes	No	0	9	8
175	R:R:F318	R:R:V392	3.93	Yes	Yes	2	9	9
176	R:R:T372	R:R:V319	4.76	No	No	0	9	7
177	R:R:I389	R:R:V321	6.14	No	No	2	9	8
178	R:R:M326	R:R:Y322	13.17	No	Yes	0	8	9
179	R:R:L371	R:R:Y322	7.03	No	Yes	0	8	9
180	R:R:T372	R:R:Y322	6.24	No	Yes	0	9	9
181	R:R:I375	R:R:Y322	8.46	Yes	Yes	2	7	9
182	R:R:F403	R:R:Y322	5.16	Yes	Yes	2	8	9
183	R:R:W365	R:R:Y323	7.72	Yes	No	0	9	8
184	R:R:P368	R:R:Y323	6.95	No	No	0	9	8
185	R:R:T372	R:R:Y323	3.75	No	No	0	9	8
186	R:R:A327	R:R:P368	3.74	No	No	0	9	9
187	R:R:V329	R:R:V411	9.62	No	No	0	6	5
188	R:R:V334	R:R:W331	6.13	No	Yes	6	7	9
189	R:R:F360	R:R:W331	4.01	Yes	Yes	6	9	9
190	R:R:H361	R:R:W331	10.58	No	Yes	6	9	9
191	R:R:T364	R:R:W331	19.41	No	Yes	6	9	9
192	R:R:W331	R:R:W365	14.99	Yes	Yes	6	9	9
193	R:R:F332	R:R:T336	5.19	No	Yes	0	9	7
194	R:R:F332	R:R:F460	4.29	No	Yes	0	9	5
195	R:R:F332	R:R:V463	3.93	No	No	0	9	7
196	R:R:F360	R:R:V334	9.18	Yes	No	6	9	7
197	R:R:G415	R:R:T336	5.46	No	Yes	0	8	7
198	R:R:F418	R:R:T336	5.19	Yes	Yes	0	8	7
199	R:R:L419	R:R:T336	7.37	No	Yes	0	7	7
200	R:R:T341	R:R:Y337	14.98	No	Yes	4	6	7
201	R:R:Y337	R:R:Y350	4.96	Yes	Yes	4	7	7
202	R:R:F418	R:R:Y337	7.22	Yes	Yes	4	8	7
203	R:R:Y337	S:S:Y359	3.97	Yes	Yes	4	7	7
204	R:R:F343	R:R:W339	11.02	No	Yes	0	9	9
205	R:R:L452	R:R:W339	5.69	No	Yes	0	8	9
206	R:R:G453	R:R:W339	8.44	No	Yes	0	5	9
207	R:R:F457	R:R:W339	6.01	No	Yes	0	4	9
208	R:R:H340	R:R:K344	7.86	Yes	Yes	4	7	6
209	R:R:F418	R:R:H340	5.66	Yes	Yes	4	8	7
210	R:R:H340	R:R:R421	18.05	Yes	Yes	4	7	7
211	R:R:G422	R:R:H340	4.77	No	Yes	0	8	7
212	R:R:H340	R:R:T425	4.11	Yes	No	4	7	7
213	R:R:H340	S:S:Y359	4.36	Yes	Yes	4	7	7
214	R:R:T341	R:R:Y350	8.74	No	Yes	4	6	7
215	R:R:M449	R:R:S342	6.13	No	No	0	9	8
216	R:R:F343	R:R:L426	10.96	No	No	0	9	9
217	R:R:F343	R:R:M449	13.68	No	No	0	9	9
218	R:R:K344	R:R:Y350	4.78	Yes	Yes	4	6	7
219	R:R:K344	R:R:R421	4.95	Yes	Yes	4	6	7
220	R:R:K344	R:R:T425	9.01	Yes	No	4	6	7
221	R:R:A345	R:R:P352	5.61	No	No	0	7	7
222	R:R:Y350	S:S:S358	10.17	Yes	No	0	7	6
223	R:R:Y350	S:S:Y359	4.96	Yes	Yes	4	7	7
224	R:R:Q351	S:S:S358	4.33	No	No	0	7	6
225	R:R:K356	R:R:P352	11.71	No	No	0	8	7
226	R:R:H361	R:R:W365	9.52	No	Yes	6	9	9
227	R:R:L362	S:S:V414	4.47	No	No	12	5	5
228	R:R:L362	S:S:F418	6.09	No	Yes	12	5	8
229	R:R:T364	R:R:W365	8.49	No	Yes	6	9	9
230	R:R:F369	R:R:V373	5.24	No	No	0	7	7
231	R:R:F369	S:S:L410	4.87	No	Yes	0	7	4
232	R:R:V370	S:S:L367	4.47	No	No	0	5	5
233	R:R:V370	S:S:L371	4.47	No	No	0	5	8
234	R:R:L371	S:S:V370	4.47	No	No	0	8	5
235	R:R:A374	S:S:F403	4.16	No	Yes	0	5	8
236	R:R:I375	R:R:V392	12.29	Yes	Yes	2	7	9
237	R:R:F403	R:R:I375	15.07	Yes	Yes	2	8	7
238	R:R:V378	S:S:Y399	15.14	No	No	0	5	5
239	R:R:N396	R:R:Q380	6.6	No	No	0	7	7
240	R:R:Q380	R:R:Y399	24.8	No	No	0	7	5
241	R:R:D382	R:R:Y394	5.75	No	Yes	0	9	5
242	R:R:D382	R:R:K395	4.15	No	No	0	9	3
243	R:R:C390	R:R:G383	3.92	No	No	0	9	8
244	R:R:D384	R:R:V386	8.76	Yes	Yes	2	8	5
245	R:R:D384	R:R:S387	7.36	Yes	No	2	8	8
246	R:R:D384	R:R:Y394	9.2	Yes	Yes	2	8	5
247	R:R:S387	R:R:Y394	6.36	No	Yes	2	8	5
248	R:R:F391	R:R:I389	3.77	Yes	No	2	8	9
249	R:R:F391	R:R:V392	3.93	Yes	Yes	2	8	9
250	R:R:F391	R:R:Y394	8.25	Yes	Yes	2	8	5
251	R:R:F391	R:R:V404	5.24	Yes	No	0	8	7
252	R:R:F403	R:R:V392	5.24	Yes	Yes	2	8	9
253	R:R:K395	R:R:N396	8.39	No	No	0	3	7
254	R:R:R398	R:R:Y397	14.4	No	Yes	0	1	3
255	R:R:Q477	R:R:Y397	6.76	Yes	Yes	2	6	3
256	R:R:A478	R:R:Y397	5.34	No	Yes	0	3	3
257	R:R:E481	R:R:Y397	6.73	No	Yes	2	5	3
258	R:R:Y399	S:S:V378	11.36	No	No	0	5	5
259	R:R:Y399	S:S:Y399	10.92	No	No	0	5	5
260	R:R:H470	R:R:R400	10.16	No	No	0	7	9
261	R:R:D473	R:R:R400	11.91	No	No	0	8	9
262	R:R:A401	R:R:F474	4.16	No	No	0	6	6
263	R:R:F403	S:S:F403	6.43	Yes	Yes	2	8	8
264	R:R:H470	R:R:V404	6.92	No	No	0	7	7
265	R:R:F467	R:R:L405	8.53	Yes	No	0	7	8
266	R:R:F471	R:R:L405	7.31	No	No	13	4	8
267	R:R:F474	R:R:L405	6.09	No	No	13	6	8
268	R:R:F467	R:R:I408	5.02	Yes	No	0	7	7
269	R:R:F467	R:R:G409	4.52	Yes	No	0	7	4
270	R:R:F460	R:R:L412	4.87	Yes	Yes	0	5	7
271	R:R:L412	R:R:V463	4.47	Yes	No	0	7	7
272	R:R:L412	R:R:L464	4.15	Yes	No	0	7	4
273	R:R:F467	R:R:L412	4.87	Yes	Yes	0	7	7
274	R:R:V414	S:S:L362	4.47	No	No	0	5	5
275	R:R:F418	R:R:Y417	6.19	Yes	No	4	8	5
276	R:R:R421	R:R:Y417	11.32	Yes	No	4	7	5
277	R:R:Y417	S:S:Y359	8.94	No	Yes	4	5	7
278	R:R:F418	S:S:Y359	9.28	Yes	Yes	4	8	7
279	R:R:F418	S:S:L362	7.31	Yes	No	0	8	5
280	R:R:F457	R:R:L419	19.49	No	No	0	4	7
281	R:R:R421	S:S:Y359	6.17	Yes	Yes	4	7	7
282	R:R:F427	R:R:V423	3.93	No	No	0	7	7
283	R:R:H433	R:R:I429	7.95	Yes	No	0	8	7
284	R:R:I429	R:R:L437	4.28	No	No	0	7	6
285	R:R:K430	R:R:L437	4.23	No	No	0	8	6
286	R:R:H433	R:R:L436	5.14	Yes	No	0	8	6
287	R:R:I454	R:R:L450	4.28	No	No	0	6	6
288	R:R:F455	R:R:R451	7.48	Yes	No	11	8	9
289	R:R:R451	R:R:W535	13.99	No	Yes	11	9	9
290	R:R:R451	R:R:T538	3.88	No	No	0	9	8
291	R:R:L452	R:R:W535	4.56	No	Yes	0	8	9
292	R:R:F455	R:R:M532	8.71	Yes	Yes	0	8	8
293	R:R:F455	R:R:T534	5.19	Yes	No	0	8	7
294	R:R:F455	R:R:W535	11.02	Yes	Yes	11	8	9
295	R:R:F462	R:R:L458	4.87	No	No	0	7	6
296	R:R:F462	R:R:T528	6.49	No	No	0	7	7
297	R:R:N521	R:R:T466	4.39	Yes	No	0	8	8
298	R:R:C469	R:R:N521	6.3	No	Yes	0	7	8
299	R:R:H470	R:R:N521	14.03	No	Yes	0	7	8
300	R:R:F471	R:R:F474	5.36	No	No	13	4	6
301	R:R:N476	R:R:Y472	12.79	No	Yes	2	6	7
302	R:R:W480	R:R:Y472	5.79	Yes	Yes	2	9	7
303	R:R:S514	R:R:Y472	3.82	No	Yes	2	7	7
304	R:R:V517	R:R:Y472	13.88	No	Yes	2	6	7
305	R:R:D473	R:R:W480	5.58	No	Yes	0	8	9
306	R:R:D473	R:R:E518	11.69	No	No	0	8	7
307	R:R:F475	R:R:N476	4.83	No	No	0	3	6
308	R:R:N476	R:R:W480	9.04	No	Yes	2	6	9
309	R:R:Q477	R:R:W480	5.48	Yes	Yes	2	6	9
310	R:R:E481	R:R:Q477	11.47	No	Yes	2	5	6
311	R:R:E479	R:R:R482	6.98	No	No	0	2	3
312	R:R:E479	R:R:N511	9.2	No	No	0	2	4
313	R:R:N511	R:R:W480	7.91	No	Yes	0	4	9
314	R:R:P513	R:R:W480	22.97	No	Yes	0	8	9
315	R:R:K510	R:R:S483	4.59	No	No	0	4	7
316	R:R:N511	R:R:S483	10.43	No	No	0	4	7
317	R:R:L489	R:R:R485	7.29	No	No	7	4	5
318	R:R:Q491	R:R:Y487	4.51	No	No	0	4	4
319	R:R:I509	R:R:Y487	10.88	No	No	0	4	4
320	R:R:C490	R:R:C507	7.28	No	No	0	9	9
321	R:R:S514	R:R:V517	6.46	No	No	2	7	6
322	R:R:I520	R:R:L516	4.28	No	No	0	5	4
323	R:R:F526	R:R:L522	7.31	Yes	No	2	9	7
324	R:R:F526	R:R:M525	8.71	Yes	No	0	9	5
325	R:R:T534	R:R:W537	16.98	No	No	0	7	8
326	R:R:T541	R:R:V536	6.35	No	Yes	9	8	8
327	R:R:T548	R:R:W545	6.06	No	Yes	0	6	9
328	R:R:R547	R:R:T548	3.88	No	No	0	6	6
329	S:S:R199	S:S:S190	7.91	Yes	No	0	4	6
330	S:S:C193	S:S:R199	4.18	No	Yes	0	9	4
331	S:S:C193	S:S:C213	7.28	No	No	0	9	9
332	S:S:P196	S:S:Q216	6.32	Yes	No	0	7	7
333	S:S:P196	S:S:P220	7.79	Yes	No	0	7	8
334	S:S:P196	S:S:Y487	4.17	Yes	No	14	7	4
335	S:S:P196	S:S:V488	5.3	Yes	No	0	7	6
336	S:S:P196	S:S:Q491	4.74	Yes	No	14	7	4
337	S:S:L197	S:S:V210	4.47	No	No	0	9	5
338	S:S:C213	S:S:L197	4.76	No	No	0	9	9
339	S:S:D201	S:S:R199	7.15	No	Yes	0	5	4
340	S:S:G212	S:S:R199	4.5	No	Yes	0	7	4
341	S:S:S205	S:S:T200	4.8	Yes	No	8	7	6
342	S:S:D298	S:S:T200	11.56	Yes	No	8	7	6
343	S:S:N202	S:S:P203	4.89	Yes	No	0	5	4
344	S:S:K204	S:S:N202	5.6	No	Yes	0	3	5
345	S:S:N202	S:S:S205	10.43	Yes	Yes	8	5	7
346	S:S:N202	S:S:R296	6.03	Yes	Yes	8	5	6
347	S:S:D298	S:S:N202	5.39	Yes	Yes	8	7	5
348	S:S:P203	S:S:W206	12.16	No	No	0	4	4
349	S:S:K204	S:S:S308	6.12	No	No	0	3	8
350	S:S:R296	S:S:S205	9.22	Yes	Yes	8	6	7
351	S:S:D298	S:S:S205	8.83	Yes	Yes	8	7	7
352	S:S:S205	S:S:T300	6.4	Yes	Yes	8	7	7
353	S:S:E211	S:S:W206	5.45	No	No	0	5	4
354	S:S:G212	S:S:W206	8.44	No	No	0	7	4
355	S:S:E208	S:S:Y207	13.47	No	No	0	4	7
356	S:S:V488	S:S:Y207	8.83	No	No	0	6	7
357	S:S:E208	S:S:R485	12.79	No	No	0	4	5
358	S:S:I215	S:S:M301	5.83	No	No	0	5	4
359	S:S:F484	S:S:I215	5.02	Yes	No	0	6	5
360	S:S:C217	S:S:C295	7.28	No	No	1	9	9
361	S:S:E224	S:S:Q218	5.1	No	No	0	4	5
362	S:S:H227	S:S:Q218	17.31	Yes	No	1	7	5
363	S:S:Q218	S:S:S385	4.33	No	No	1	5	7
364	S:S:N219	S:S:P220	4.89	Yes	No	0	7	8
365	S:S:L221	S:S:N219	4.12	No	Yes	0	6	7
366	S:S:F222	S:S:N219	8.46	Yes	Yes	1	6	7
367	S:S:D384	S:S:N219	5.39	Yes	Yes	1	8	7
368	S:S:N219	S:S:V386	4.43	Yes	Yes	1	7	5
369	S:S:F484	S:S:P220	7.22	Yes	No	0	6	8
370	S:S:F484	S:S:L221	8.53	Yes	No	0	6	6
371	S:S:I509	S:S:L221	4.28	No	No	0	4	6
372	S:S:E226	S:S:F222	5.83	No	Yes	1	8	6
373	S:S:F222	S:S:V386	5.24	Yes	Yes	1	6	5
374	S:S:F222	S:S:R512	10.69	Yes	No	1	6	6
375	S:S:F222	S:S:P513	7.22	Yes	No	0	6	8
376	S:S:F222	S:S:L515	12.18	Yes	No	0	6	5
377	S:S:E226	S:S:T223	12.7	No	No	0	8	5
378	S:S:E224	S:S:Q228	6.37	No	No	0	4	3
379	S:S:E226	S:S:R512	10.47	No	No	1	8	6
380	S:S:H227	S:S:H231	4.78	Yes	No	0	7	7
381	S:S:H227	S:S:S385	6.97	Yes	No	1	7	7
382	S:S:H227	S:S:V386	9.69	Yes	Yes	1	7	5
383	S:S:D229	S:S:K519	6.91	No	No	0	6	7
384	S:S:I234	S:S:M230	4.37	Yes	No	0	7	7
385	S:S:L515	S:S:M230	5.65	No	No	0	5	7
386	S:S:K519	S:S:M230	5.76	No	No	0	7	7
387	S:S:H231	S:S:R290	28.21	No	No	0	7	9
388	S:S:F237	S:S:Y233	10.32	No	No	0	4	6
389	S:S:K519	S:S:Y233	23.89	No	No	0	7	6
390	S:S:I234	S:S:W281	5.87	Yes	Yes	1	7	7
391	S:S:I234	S:S:Q284	4.12	Yes	Yes	1	7	9
392	S:S:F285	S:S:I234	5.02	No	Yes	1	8	7
393	S:S:A235	S:S:F285	5.55	No	No	0	5	8
394	S:S:F237	S:S:F523	5.36	No	No	0	4	6
395	S:S:F237	S:S:F526	10.72	No	Yes	0	4	9
396	S:S:G238	S:S:L282	5.13	No	No	0	7	7
397	S:S:F526	S:S:G238	6.02	Yes	No	0	9	7
398	S:S:F526	S:S:T241	11.67	Yes	No	0	9	7
399	S:S:I530	S:S:T241	7.6	No	No	0	7	7
400	S:S:C244	S:S:S533	5.16	No	No	0	6	9
401	S:S:N271	S:S:T245	4.39	No	No	0	9	8
402	S:S:F275	S:S:T245	5.19	Yes	No	0	5	8
403	S:S:F275	S:S:L246	9.74	Yes	No	0	5	6
404	S:S:F247	S:S:T251	7.78	No	No	15	8	9
405	S:S:F247	S:S:W545	11.02	No	Yes	15	8	9
406	S:S:N271	S:S:T248	13.16	No	No	0	9	8
407	S:S:S533	S:S:T248	4.8	No	No	0	9	8
408	S:S:T248	S:S:V536	11.11	No	No	0	8	8
409	S:S:F275	S:S:L249	4.87	Yes	No	0	5	6
410	S:S:T251	S:S:V536	9.52	No	No	0	9	8
411	S:S:T251	S:S:W545	12.13	No	Yes	15	9	9
412	S:S:F252	S:S:S259	6.61	No	No	0	9	8
413	S:S:F252	S:S:F268	16.08	No	Yes	0	9	8
414	S:S:F252	S:S:W535	4.01	No	Yes	0	9	9
415	S:S:D255	S:S:N258	12.12	No	No	0	8	8
416	S:S:D255	S:S:S259	8.83	No	No	0	8	8
417	S:S:D255	S:S:I544	11.2	No	No	0	8	6
418	S:S:N260	S:S:W256	20.34	No	No	0	7	7
419	S:S:N260	S:S:V265	7.39	No	Yes	0	7	8
420	S:S:N260	S:S:T357	4.39	No	No	0	7	6
421	S:S:V265	S:S:Y262	8.83	Yes	Yes	0	8	9
422	S:S:I266	S:S:Y262	4.84	Yes	Yes	0	8	9
423	S:S:T357	S:S:Y262	6.24	No	Yes	0	6	9
424	S:S:F360	S:S:Y262	7.22	No	Yes	0	9	9
425	S:S:L452	S:S:P263	6.57	No	No	0	8	9
426	S:S:A264	S:S:W535	3.89	No	Yes	0	9	9
427	S:S:F268	S:S:V265	3.93	Yes	Yes	5	8	8
428	S:S:V265	S:S:Y269	5.05	Yes	Yes	5	8	8
429	S:S:I266	S:S:W331	4.7	Yes	Yes	5	8	9
430	S:S:I266	S:S:V334	6.14	Yes	No	5	8	7
431	S:S:I266	S:S:L335	5.71	Yes	No	0	8	8
432	S:S:L267	S:S:L335	5.54	No	No	0	8	8
433	S:S:L267	S:S:W535	28.47	No	Yes	0	8	9
434	S:S:F268	S:S:Y269	12.38	Yes	Yes	5	8	8
435	S:S:W331	S:S:Y269	18.33	Yes	Yes	5	9	8
436	S:S:H361	S:S:Y269	10.89	No	Yes	5	9	8
437	S:S:W365	S:S:Y269	4.82	Yes	Yes	5	9	8
438	S:S:M532	S:S:V270	4.56	No	No	0	8	8
439	S:S:C273	S:S:G328	3.92	No	No	0	9	8
440	S:S:F274	S:S:M525	3.73	No	No	0	9	5
441	S:S:F274	S:S:T528	9.08	No	No	0	9	7
442	S:S:F274	S:S:G529	9.03	No	No	0	9	9
443	S:S:F275	S:S:I279	6.28	Yes	No	0	5	5
444	S:S:V321	S:S:W281	7.36	No	Yes	1	8	7
445	S:S:I389	S:S:W281	11.74	Yes	Yes	1	9	7
446	S:S:L522	S:S:W281	4.56	No	Yes	1	7	7
447	S:S:M525	S:S:W281	4.65	No	Yes	1	5	7
448	S:S:F526	S:S:W281	10.02	Yes	Yes	1	9	7
449	S:S:F285	S:S:Q284	16.4	No	Yes	1	8	9
450	S:S:Q284	S:S:R290	17.52	Yes	No	1	9	9
451	S:S:G388	S:S:Q284	8.22	No	Yes	1	9	9
452	S:S:G388	S:S:R290	4.5	No	No	1	9	9
453	S:S:C295	S:S:R291	4.18	No	No	0	9	5
454	S:S:E292	S:S:T311	12.7	No	No	0	5	7
455	S:S:E292	S:S:S313	8.62	No	No	0	5	7
456	S:S:I293	S:S:I317	8.83	No	No	0	8	7
457	S:S:D298	S:S:R296	5.96	Yes	Yes	8	7	6
458	S:S:R296	S:S:T300	5.17	Yes	Yes	8	6	7
459	S:S:E310	S:S:R296	20.93	No	Yes	0	8	6
460	S:S:D298	S:S:T300	11.56	Yes	Yes	8	7	7
461	S:S:L303	S:S:M301	7.07	No	No	0	3	4
462	S:S:E305	S:S:R302	16.28	No	Yes	18	7	6
463	S:S:E310	S:S:R302	5.82	No	Yes	0	8	6
464	S:S:R302	S:S:T311	6.47	Yes	No	0	6	7
465	S:S:C314	S:S:R302	11.14	No	Yes	18	9	6
466	S:S:D382	S:S:L303	5.43	No	No	17	9	3
467	S:S:K395	S:S:L303	4.23	No	No	17	3	3
468	S:S:E305	S:S:T307	5.64	No	No	0	7	6
469	S:S:C314	S:S:E305	10.64	No	No	18	9	7
470	S:S:P306	S:S:V315	5.3	No	No	0	5	7
471	S:S:L376	S:S:P306	6.57	No	No	0	8	5
472	S:S:C314	S:S:C390	7.28	No	No	0	9	9
473	S:S:F318	S:S:Y322	9.28	Yes	Yes	2	9	9
474	S:S:F318	S:S:I375	10.05	Yes	Yes	2	9	7
475	S:S:F318	S:S:V381	15.73	Yes	No	0	9	8
476	S:S:I389	S:S:V321	6.14	Yes	No	1	9	8
477	S:S:M326	S:S:Y322	13.17	No	Yes	0	8	9
478	S:S:L371	S:S:Y322	5.86	No	Yes	0	8	9
479	S:S:T372	S:S:Y322	6.24	No	Yes	0	9	9
480	S:S:I375	S:S:Y322	8.46	Yes	Yes	2	7	9
481	S:S:F403	S:S:Y322	5.16	Yes	Yes	2	8	9
482	S:S:W365	S:S:Y323	6.75	Yes	Yes	0	9	8
483	S:S:P368	S:S:Y323	6.95	No	Yes	0	9	8
484	S:S:T372	S:S:Y323	4.99	No	Yes	0	9	8
485	S:S:A327	S:S:P368	3.74	No	No	0	9	9
486	S:S:V329	S:S:V411	9.62	No	No	0	6	5
487	S:S:V334	S:S:W331	4.9	No	Yes	5	7	9
488	S:S:T364	S:S:W331	21.83	No	Yes	5	9	9
489	S:S:W331	S:S:W365	14.99	Yes	Yes	5	9	9
490	S:S:F332	S:S:T336	5.19	No	Yes	0	9	7
491	S:S:F332	S:S:F460	4.29	No	Yes	0	9	5
492	S:S:F360	S:S:V334	6.55	No	No	0	9	7
493	S:S:G415	S:S:T336	5.46	No	Yes	0	8	7
494	S:S:F418	S:S:T336	5.19	Yes	Yes	0	8	7
495	S:S:L419	S:S:T336	5.9	No	Yes	0	7	7
496	S:S:T341	S:S:Y337	9.99	No	No	0	6	7
497	S:S:F418	S:S:Y337	10.32	Yes	No	0	8	7
498	S:S:F343	S:S:W339	7.02	Yes	Yes	0	9	9
499	S:S:G422	S:S:W339	4.22	No	Yes	0	8	9
500	S:S:L452	S:S:W339	6.83	No	Yes	0	8	9
501	S:S:G453	S:S:W339	8.44	No	Yes	0	5	9
502	S:S:F457	S:S:W339	4.01	No	Yes	0	4	9
503	S:S:H340	S:S:T341	4.11	No	No	0	7	6
504	S:S:F418	S:S:H340	10.18	Yes	No	0	8	7
505	S:S:F343	S:S:S342	5.28	Yes	No	19	9	8
506	S:S:M449	S:S:S342	7.67	No	No	19	9	8
507	S:S:F343	S:S:T425	5.19	Yes	No	0	9	7
508	S:S:F343	S:S:L426	8.53	Yes	No	0	9	9
509	S:S:F343	S:S:M449	8.71	Yes	No	19	9	9
510	S:S:I445	S:S:L346	9.99	Yes	No	0	9	6
511	S:S:H361	S:S:W365	9.52	No	Yes	5	9	9
512	S:S:T364	S:S:W365	7.28	No	Yes	5	9	9
513	S:S:F369	S:S:V373	3.93	No	No	0	7	7
514	S:S:I375	S:S:V392	12.29	Yes	No	2	7	9
515	S:S:F403	S:S:I375	15.07	Yes	Yes	2	8	7
516	S:S:N396	S:S:Q380	6.6	No	No	0	7	7
517	S:S:Q380	S:S:Y399	24.8	No	No	0	7	5
518	S:S:D382	S:S:K395	4.15	No	No	17	9	3
519	S:S:D384	S:S:V386	7.3	Yes	Yes	1	8	5
520	S:S:D384	S:S:S387	7.36	Yes	Yes	1	8	8
521	S:S:D384	S:S:Y394	9.2	Yes	Yes	1	8	5
522	S:S:I389	S:S:S387	4.64	Yes	Yes	1	9	8
523	S:S:S387	S:S:Y394	6.36	Yes	Yes	1	8	5
524	S:S:F391	S:S:I389	3.77	Yes	Yes	1	8	9
525	S:S:F391	S:S:Y394	9.28	Yes	Yes	1	8	5
526	S:S:F391	S:S:V404	3.93	Yes	No	0	8	7
527	S:S:F403	S:S:V392	3.93	Yes	No	2	8	9
528	S:S:K395	S:S:N396	8.39	No	No	0	3	7
529	S:S:R398	S:S:Y397	13.38	No	Yes	0	1	3
530	S:S:F474	S:S:Y397	4.13	Yes	Yes	1	6	3
531	S:S:Q477	S:S:Y397	6.76	Yes	Yes	1	6	3
532	S:S:A478	S:S:Y397	5.34	No	Yes	0	3	3
533	S:S:E481	S:S:Y397	7.86	No	Yes	1	5	3
534	S:S:H470	S:S:R400	11.28	No	No	0	7	9
535	S:S:D473	S:S:R400	10.72	No	No	0	8	9
536	S:S:A401	S:S:F474	4.16	No	Yes	0	6	6
537	S:S:H470	S:S:V404	6.92	No	No	0	7	7
538	S:S:F467	S:S:L405	8.53	Yes	No	0	7	8
539	S:S:F471	S:S:L405	7.31	No	No	1	4	8
540	S:S:F474	S:S:L405	4.87	Yes	No	1	6	8
541	S:S:F467	S:S:I408	5.02	Yes	No	0	7	7
542	S:S:F467	S:S:G409	4.52	Yes	No	0	7	4
543	S:S:L410	S:S:V414	4.47	Yes	No	0	4	5
544	S:S:F460	S:S:L412	6.09	Yes	Yes	0	5	7
545	S:S:L412	S:S:V463	4.47	Yes	No	0	7	7
546	S:S:L412	S:S:L464	4.15	Yes	No	0	7	4
547	S:S:F467	S:S:L412	4.87	Yes	Yes	0	7	7
548	S:S:F418	S:S:V414	3.93	Yes	No	12	8	5
549	S:S:F460	S:S:G416	4.52	Yes	No	0	5	5
550	S:S:F418	S:S:Y417	6.19	Yes	No	0	8	5
551	S:S:R421	S:S:Y417	15.43	No	No	0	7	5
552	S:S:F457	S:S:L419	19.49	No	No	0	4	7
553	S:S:K430	S:S:L426	4.23	No	No	0	8	9
554	S:S:K430	S:S:L437	4.23	No	No	0	8	6
555	S:S:H433	S:S:N432	20.41	No	No	0	8	6
556	S:S:H433	S:S:L436	5.14	No	No	0	8	6
557	S:S:I445	S:S:M449	10.2	Yes	No	0	9	9
558	S:S:F455	S:S:R451	9.62	Yes	No	16	8	9
559	S:S:R451	S:S:W535	9	No	Yes	16	9	9
560	S:S:R451	S:S:T538	5.17	No	No	0	9	8
561	S:S:F455	S:S:I454	3.77	Yes	No	0	8	6
562	S:S:F455	S:S:M532	3.73	Yes	No	0	8	8
563	S:S:F455	S:S:W535	12.03	Yes	Yes	16	8	9
564	S:S:F462	S:S:L458	4.87	No	No	0	7	6
565	S:S:F462	S:S:T528	5.19	No	No	0	7	7
566	S:S:A524	S:S:I465	4.87	No	No	0	7	5
567	S:S:N521	S:S:T466	5.85	Yes	No	0	8	8
568	S:S:C469	S:S:N521	6.3	No	Yes	0	7	8
569	S:S:H470	S:S:N521	14.03	No	Yes	0	7	8
570	S:S:F471	S:S:F474	5.36	No	Yes	1	4	6
571	S:S:N476	S:S:Y472	12.79	No	No	1	6	7
572	S:S:W480	S:S:Y472	5.79	Yes	No	1	9	7
573	S:S:V517	S:S:Y472	10.09	No	No	0	6	7
574	S:S:D473	S:S:W480	5.58	No	Yes	0	8	9
575	S:S:D473	S:S:E518	11.69	No	No	0	8	7
576	S:S:N476	S:S:W480	10.17	No	Yes	1	6	9
577	S:S:Q477	S:S:W480	5.48	Yes	Yes	1	6	9
578	S:S:E481	S:S:Q477	7.65	No	Yes	1	5	6
579	S:S:E479	S:S:R482	8.14	No	No	0	2	3
580	S:S:E479	S:S:N511	14.46	No	Yes	0	2	4
581	S:S:N511	S:S:W480	6.78	Yes	Yes	1	4	9
582	S:S:P513	S:S:W480	17.57	No	Yes	0	8	9
583	S:S:K510	S:S:S483	6.12	No	No	1	4	7
584	S:S:N511	S:S:S483	8.94	Yes	No	1	4	7
585	S:S:F484	S:S:V488	3.93	Yes	No	0	6	6
586	S:S:L489	S:S:R485	8.5	No	No	0	4	5
587	S:S:Q491	S:S:Y487	11.27	No	No	14	4	4
588	S:S:I509	S:S:Y487	10.88	No	No	0	4	4
589	S:S:C490	S:S:C507	5.46	No	No	0	9	9
590	S:S:C507	S:S:Q491	7.63	No	No	0	9	4
591	S:S:D506	S:S:E508	3.9	No	No	0	3	4
592	S:S:K510	S:S:N511	5.6	No	Yes	1	4	4
593	S:S:S514	S:S:V517	6.46	No	No	0	7	6
594	S:S:I520	S:S:L516	4.28	No	No	0	5	4
595	S:S:F526	S:S:L522	4.87	Yes	No	1	9	7
596	S:S:F526	S:S:M525	11.2	Yes	No	1	9	5
597	S:S:T534	S:S:W537	13.34	No	No	0	7	8
598	S:S:T541	S:S:V536	4.76	No	No	0	8	8
599	S:S:T538	S:S:T541	4.71	No	No	0	8	8
600	S:S:T548	S:S:W545	4.85	No	Yes	0	6	9
601	R:R:G242	R:R:S278	3.71	No	No	0	4	8
602	S:S:G191	S:S:S190	3.71	No	No	0	5	6
603	S:S:G242	S:S:S278	3.71	No	No	0	4	8
604	S:S:G435	S:S:S438	3.71	No	No	0	5	8
605	S:S:S533	S:S:W537	3.71	No	No	0	9	8
606	R:R:V423	R:R:W339	3.68	No	Yes	0	7	9
607	S:S:V423	S:S:W339	3.68	No	Yes	0	7	9
608	R:R:F275	R:R:L249	3.65	Yes	No	0	5	6
609	R:R:F318	R:R:L376	3.65	Yes	No	0	9	8
610	S:S:F318	S:S:L376	3.65	Yes	No	0	9	8
611	S:S:K356	S:S:Y262	3.58	No	Yes	0	8	9
612	R:R:P196	R:R:V488	3.53	Yes	No	0	7	6
613	R:R:G280	R:R:I320	3.53	No	No	0	7	5
614	R:R:P407	S:S:V370	3.53	No	No	0	9	5
615	R:R:G527	R:R:I530	3.53	No	No	0	5	7
616	S:S:G280	S:S:I320	3.53	No	No	0	7	5
617	S:S:P368	S:S:V330	3.53	No	No	0	9	6
618	S:S:G527	S:S:I530	3.53	No	No	0	5	7
619	S:S:L197	S:S:Y207	3.52	No	No	0	9	7
620	S:S:P263	S:S:T448	3.5	No	No	0	9	8
621	R:R:C217	R:R:V294	3.42	No	No	0	9	8
622	R:R:G456	R:R:L335	3.42	No	No	0	7	8
623	R:R:A324	R:R:V276	3.39	No	No	0	7	5
624	S:S:A324	S:S:V276	3.39	No	No	0	7	5
625	S:S:M326	S:S:P407	3.35	No	No	0	8	9
626	R:R:C469	R:R:I520	3.27	No	No	0	7	5
627	S:S:C469	S:S:I520	3.27	No	No	0	7	5
628	R:R:A283	R:R:I317	3.25	No	No	0	5	7
629	R:R:A442	R:R:I445	3.25	No	No	0	8	9
630	R:R:A524	R:R:I465	3.25	No	No	0	7	5
631	S:S:A283	S:S:I317	3.25	No	No	0	5	7
632	S:S:A442	S:S:I445	3.25	No	Yes	0	8	9
633	R:R:A459	R:R:M532	3.22	No	Yes	0	7	8
634	S:S:A459	S:S:M532	3.22	No	No	0	7	8
635	R:R:V329	R:R:V463	3.21	No	No	0	6	7
636	R:R:V333	R:R:V411	3.21	No	No	0	9	5
637	S:S:V333	S:S:V411	3.21	No	No	0	9	5
638	R:R:S278	R:R:T241	3.2	No	No	0	8	7
639	S:S:S278	S:S:T241	3.2	No	No	0	8	7
640	R:R:G347	R:R:H433	3.18	No	Yes	0	7	8
641	R:R:T364	R:R:V330	3.17	No	No	0	9	6
642	S:S:T372	S:S:V319	3.17	No	No	0	9	7
643	S:S:T336	S:S:V333	3.17	Yes	No	0	7	9
644	R:R:A442	R:R:L436	3.15	No	No	0	8	6
645	R:R:A531	R:R:L458	3.15	No	No	0	6	6
646	S:S:A531	S:S:L458	3.15	No	No	0	6	6
647	R:R:T538	R:R:T541	3.14	No	No	0	8	8
648	R:R:R261	R:R:Y262	3.09	No	Yes	0	7	9
649	S:S:F369	S:S:Y323	3.09	No	Yes	0	7	8
650	R:R:I530	R:R:V240	3.07	No	No	0	7	4
651	R:R:I293	R:R:V294	3.07	No	No	0	8	8
652	R:R:I413	R:R:V414	3.07	No	No	0	3	5
653	S:S:I530	S:S:V240	3.07	No	No	0	7	4
654	R:R:K444	R:R:S443	3.06	No	No	0	9	6
655	R:R:C213	R:R:Q192	3.05	No	No	0	9	4
656	S:S:C193	S:S:Q192	3.05	No	No	0	9	4
657	R:R:M532	R:R:V270	3.04	Yes	No	0	8	8
658	S:S:A297	S:S:E310	3.02	No	No	0	5	8
659	R:R:F460	R:R:G416	3.01	Yes	No	0	5	5
660	R:R:F460	R:R:G461	3.01	Yes	No	0	5	5
661	S:S:F460	S:S:G461	3.01	Yes	No	0	5	5
662	R:R:G288	R:R:R291	3	No	No	0	6	5
663	R:R:S366	S:S:L410	3	No	Yes	0	7	4
664	S:S:L437	S:S:S438	3	No	No	0	6	8
665	R:R:L312	R:R:V315	2.98	No	No	0	7	7
666	R:R:Y359	S:S:Y337	2.98	No	No	0	7	7
667	R:R:L410	S:S:V370	2.98	No	No	0	4	5
668	R:R:N432	R:R:S428	2.98	No	No	0	6	5
669	S:S:N309	S:S:S308	2.98	No	No	0	6	8
670	S:S:L312	S:S:V315	2.98	No	No	0	7	7
671	S:S:I316	S:S:I320	2.94	No	No	0	5	5
672	S:S:I317	S:S:I389	2.94	No	Yes	0	7	9
673	R:R:Q216	R:R:V195	2.87	No	No	0	7	4
674	R:R:Q216	R:R:V198	2.87	No	No	0	7	6
675	S:S:Q216	S:S:V195	2.87	No	No	0	7	4
676	S:S:Q216	S:S:V198	2.87	No	No	0	7	6
677	R:R:I316	R:R:L312	2.85	No	No	0	5	7
678	R:R:I445	R:R:L346	2.85	No	No	0	9	6
679	S:S:I316	S:S:L312	2.85	No	No	0	5	7
680	S:S:I413	S:S:L410	2.85	No	Yes	0	3	4
681	S:S:I429	S:S:L426	2.85	No	No	0	7	9
682	R:R:L325	R:R:M326	2.83	No	No	0	5	8
683	R:R:L458	R:R:M532	2.83	No	Yes	0	6	8
684	S:S:L325	S:S:M326	2.83	No	No	0	5	8
685	S:S:I445	S:S:N446	2.83	Yes	No	0	9	7
686	R:R:K430	R:R:L426	2.82	No	No	0	8	9
687	R:R:L363	S:S:L363	2.77	No	No	0	4	4
688	R:R:F403	S:S:A374	2.77	Yes	No	2	8	5
689	R:R:A524	R:R:F462	2.77	No	No	0	7	7
690	R:R:D486	R:R:K510	2.77	No	No	0	4	4
691	S:S:A374	S:S:F403	2.77	No	Yes	2	5	8
692	S:S:A524	S:S:F462	2.77	No	No	0	7	7
693	R:R:L437	R:R:N446	2.75	No	No	0	6	7
694	R:R:F360	R:R:S358	2.64	Yes	No	0	9	6
695	R:R:F268	R:R:V253	2.62	Yes	No	0	8	5
696	S:S:F268	S:S:V253	2.62	Yes	No	0	8	5
697	R:R:C273	R:R:W365	2.61	No	Yes	0	9	9
698	S:S:C273	S:S:W365	2.61	No	Yes	0	9	9
699	R:R:A250	R:R:W545	2.59	No	Yes	0	6	9
700	R:R:A254	R:R:W545	2.59	No	Yes	0	8	9
701	R:R:A264	R:R:W535	2.59	No	Yes	0	9	9
702	S:S:A250	S:S:W545	2.59	No	Yes	0	6	9
703	R:R:H433	R:R:N432	2.55	Yes	No	0	8	6
704	S:S:C390	S:S:G383	1.96	No	No	0	9	8
705	R:R:A324	R:R:G277	1.95	No	No	0	7	6
706	R:R:A374	S:S:G402	1.95	No	No	0	5	5
707	R:R:A377	S:S:G402	1.95	No	No	0	8	5
708	R:R:A401	R:R:G402	1.95	No	No	0	6	5
709	R:R:A406	R:R:G402	1.95	No	No	0	5	5
710	R:R:G402	S:S:A377	1.95	No	No	0	5	8
711	S:S:A324	S:S:G277	1.95	No	No	0	7	6
712	S:S:A401	S:S:G402	1.95	No	No	0	6	5
713	R:R:A338	R:R:P263	1.87	No	No	0	8	9
714	R:R:A379	R:R:P306	1.87	No	No	0	6	5
715	S:S:A338	S:S:P263	1.87	No	No	0	8	9
716	S:S:A379	S:S:P306	1.87	No	No	0	6	5
717	S:S:A406	S:S:P407	1.87	No	No	0	5	9
718	R:R:G435	R:R:S438	1.86	No	Yes	0	5	8
719	R:R:G280	R:R:V321	1.84	No	No	0	7	8
720	R:R:G393	R:R:V392	1.84	No	Yes	0	9	9
721	S:S:G383	S:S:V294	1.84	No	Yes	0	8	8
722	S:S:G388	S:S:V294	1.84	No	Yes	1	9	8
723	S:S:G393	S:S:V392	1.84	No	No	0	9	9
724	R:R:G214	R:R:T200	1.82	No	No	0	8	6
725	R:R:G214	R:R:T300	1.82	No	Yes	0	8	7
726	R:R:G347	R:R:T348	1.82	No	No	0	7	7
727	S:S:G214	S:S:T200	1.82	No	No	0	8	6
728	S:S:G214	S:S:T300	1.82	No	Yes	0	8	7
729	R:R:P263	R:R:T448	1.75	No	No	0	9	8
730	R:R:G304	R:R:L303	1.71	No	No	0	5	3
731	R:R:A441	R:R:S438	1.71	No	Yes	0	8	8
732	S:S:C217	S:S:V294	1.71	No	Yes	1	9	8
733	S:S:C295	S:S:V294	1.71	No	Yes	1	9	8
734	S:S:G456	S:S:L335	1.71	No	No	0	7	8
735	S:S:G456	S:S:L419	1.71	No	No	0	7	7
736	R:R:A225	R:R:T223	1.68	No	No	0	4	5
737	R:R:D298	R:R:G299	1.68	Yes	No	0	7	4
738	R:R:A540	R:R:T538	1.68	No	No	0	8	8
739	S:S:A225	S:S:T223	1.68	No	No	0	4	5
740	S:S:A254	S:S:T548	1.68	No	No	0	8	6
741	S:S:D298	S:S:G299	1.68	Yes	No	0	7	4
742	S:S:D382	S:S:G304	1.68	No	No	0	9	5
743	S:S:A540	S:S:T538	1.68	No	No	0	8	8
744	R:R:L367	R:R:P368	1.64	No	No	0	5	9
745	R:R:A289	R:R:I293	1.62	No	No	0	7	8
746	S:S:A289	S:S:I293	1.62	No	No	0	7	8
747	R:R:A289	R:R:M286	1.61	No	No	0	7	4
748	S:S:A289	S:S:M286	1.61	No	No	0	7	4
749	R:R:A272	R:R:L249	1.58	No	No	0	4	6
750	R:R:P352	R:R:Q351	1.58	No	No	0	7	7
751	S:S:A272	S:S:L249	1.58	No	No	0	4	6
752	S:S:A345	S:S:L346	1.58	No	No	0	7	6
753	R:R:T348	R:R:T349	1.57	No	No	0	7	6
754	R:R:I320	R:R:V276	1.54	No	No	0	5	5
755	S:S:I320	S:S:V276	1.54	No	No	0	5	5
756	R:R:K440	R:R:S438	1.53	No	Yes	0	6	8
757	R:R:A297	R:R:E310	1.51	No	Yes	0	5	8
758	R:R:L367	S:S:S366	1.5	No	No	0	5	7
759	R:R:L464	R:R:S468	1.5	No	No	0	4	4
760	S:S:L362	S:S:S366	1.5	No	No	0	5	7
761	R:R:I420	R:R:M424	1.46	No	No	0	5	5
762	S:S:I420	S:S:M424	1.46	No	No	0	5	5
763	R:R:E439	R:R:S438	1.44	No	Yes	0	5	8
764	S:S:I429	S:S:L436	1.43	No	No	0	7	6
765	S:S:I454	S:S:L450	1.43	No	No	0	6	6
766	R:R:K539	R:R:L543	1.41	No	No	0	5	4
767	R:R:C295	R:R:R291	1.39	No	No	0	9	5
768	R:R:L363	R:R:L367	1.38	No	No	0	4	5
769	R:R:E447	R:R:L450	1.33	No	No	0	6	6
770	S:S:F427	S:S:S431	1.32	No	No	0	7	5
771	S:S:D209	S:S:E208	1.3	No	No	0	4	4
772	S:S:M424	S:S:R421	1.24	No	No	0	5	7
773	S:S:F475	S:S:N476	1.21	No	No	0	3	6
774	S:S:D486	S:S:R482	1.19	No	No	0	4	3
775	S:S:D486	S:S:R485	1.19	No	No	0	4	5
776	S:S:R257	S:S:W256	1	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.662	15	2	0
2	M:M:?1	10.11	13	1	0
3	R:R:P196	6.1475	4	0	7
4	R:R:L197	4.5975	4	7	9
5	R:R:N202	6.5275	4	3	5
6	R:R:S205	8.07	5	3	7
7	R:R:Y207	7.4975	4	7	7
8	R:R:N219	6.09667	6	2	7
9	R:R:L221	4.8775	4	2	6
10	R:R:F222	8.62429	7	2	6
11	R:R:H227	11.2125	4	2	7
12	R:R:M230	5.03	4	0	7
13	R:R:T251	9.11	4	9	9
14	R:R:Y262	5.666	5	0	9
15	R:R:F268	8.788	5	0	8
16	R:R:Y269	9.012	5	6	8
17	R:R:F275	5.6075	4	0	5
18	R:R:W281	8.10167	6	2	7
19	R:R:R296	6.39333	6	3	6
20	R:R:D298	7.98667	6	3	7
21	R:R:T300	7.075	4	3	7
22	R:R:R302	8.4375	4	3	6
23	R:R:E310	5.215	4	3	8
24	R:R:F318	8.528	5	2	9
25	R:R:Y322	8.22333	6	2	9
26	R:R:W331	11.5	7	6	9
27	R:R:T336	5.8025	4	0	7
28	R:R:Y337	7.7825	4	4	7
29	R:R:W339	6.968	5	0	9
30	R:R:H340	7.46833	6	4	7
31	R:R:K344	6.65	4	4	6
32	R:R:Y350	6.722	5	4	7
33	R:R:F360	5.7625	4	6	9
34	R:R:W365	7.865	6	6	9
35	R:R:I375	11.4675	4	2	7
36	R:R:D384	7.662	5	2	8
37	R:R:V386	7.03	4	2	5
38	R:R:F391	5.23	5	2	8
39	R:R:V392	5.446	5	2	9
40	R:R:Y394	8.298	5	2	5
41	R:R:Y397	8.3075	4	2	3
42	R:R:F403	6.934	5	2	8
43	R:R:L412	4.59	4	0	7
44	R:R:F418	6.80833	6	4	8
45	R:R:R421	10.1225	4	4	7
46	R:R:H433	4.705	4	0	8
47	R:R:S438	1.635	4	0	8
48	R:R:F455	8.1	4	11	8
49	R:R:F460	3.795	4	0	5
50	R:R:F467	5.735	4	0	7
51	R:R:Y472	9.07	4	2	7
52	R:R:Q477	8.13	4	2	6
53	R:R:W480	9.46167	6	2	9
54	R:R:F484	7.5325	4	0	6
55	R:R:N521	7.5775	4	0	8
56	R:R:F526	8.09833	6	2	9
57	R:R:M532	4.408	5	0	8
58	R:R:W535	9.848	5	11	9
59	R:R:V536	8.125	4	9	8
60	R:R:W545	5.39	5	9	9
61	S:S:P196	5.664	5	14	7
62	S:S:R199	5.935	4	0	4
63	S:S:N202	6.468	5	8	5
64	S:S:S205	7.936	5	8	7
65	S:S:N219	5.71333	6	1	7
66	S:S:F222	8.27	6	1	6
67	S:S:H227	9.6875	4	1	7
68	S:S:I234	4.845	4	1	7
69	S:S:Y262	6.142	5	0	9
70	S:S:V265	6.3	4	5	8
71	S:S:I266	5.3475	4	5	8
72	S:S:F268	8.7525	4	5	8
73	S:S:Y269	10.294	5	5	8
74	S:S:F275	6.52	4	0	5
75	S:S:W281	7.55571	7	1	7
76	S:S:Q284	11.565	4	1	9
77	S:S:V294	1.775	4	1	8
78	S:S:R296	9.462	5	8	6
79	S:S:D298	7.49667	6	8	7
80	S:S:T300	6.2375	4	8	7
81	S:S:R302	9.9275	4	18	6
82	S:S:F318	9.6775	4	2	9
83	S:S:Y322	8.02833	6	2	9
84	S:S:Y323	5.445	4	0	8
85	S:S:W331	12.95	5	5	9
86	S:S:T336	4.982	5	0	7
87	S:S:W339	5.7	6	0	9
88	S:S:F343	6.946	5	19	9
89	S:S:Y359	6.28	6	4	7
90	S:S:W365	7.66167	6	5	9
91	S:S:I375	11.4675	4	2	7
92	S:S:D384	7.37	5	1	8
93	S:S:V386	6.665	4	1	5
94	S:S:S387	5.735	4	1	8
95	S:S:I389	5.846	5	1	9
96	S:S:F391	5.64	4	1	8
97	S:S:Y394	9.1925	4	1	5
98	S:S:Y397	7.494	5	1	3
99	S:S:F403	6.25333	6	2	8
100	S:S:L410	3.7975	4	0	4
101	S:S:L412	4.895	4	0	7
102	S:S:F418	6.98333	6	12	8
103	S:S:I445	6.5675	4	0	9
104	S:S:F455	7.2875	4	16	8
105	S:S:F460	4.4775	4	0	5
106	S:S:F467	5.735	4	0	7
107	S:S:F474	4.63	4	1	6
108	S:S:Q477	6.835	4	1	6
109	S:S:W480	8.56167	6	1	9
110	S:S:F484	8.658	5	0	6
111	S:S:N511	8.945	4	1	4
112	S:S:N521	7.7675	4	0	8
113	S:S:F526	9.08333	6	1	9
114	S:S:W535	11.48	5	16	9
115	S:S:W545	7.6475	4	15	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F391	90.7589	4.96	Yes	Yes	2	0	8
2	R:R:F391	R:R:V392	100	3.93	Yes	Yes	2	8	9
3	R:R:F403	R:R:V392	60.9344	5.24	Yes	Yes	2	8	9
4	R:R:F403	S:S:F403	60.277	6.43	Yes	Yes	2	8	8
5	R:R:A374	S:S:F403	40.9895	4.16	No	Yes	0	5	8
6	R:R:A374	S:S:G402	40.8758	1.95	No	No	0	5	5
7	S:S:A401	S:S:G402	40.6603	1.95	No	No	0	6	5
8	S:S:A401	S:S:F474	40.5532	4.16	No	Yes	0	6	6
9	S:S:F474	S:S:Y397	40.1344	4.13	Yes	Yes	1	6	3
10	S:S:Q477	S:S:Y397	39.5447	6.76	Yes	Yes	1	6	3
11	M:M:?1	S:S:Q477	35.7916	7.45	Yes	Yes	1	0	6
12	M:M:?1	S:S:F484	11.0007	18.59	Yes	Yes	0	0	6
13	L:L:?1	R:R:N219	40.0691	6.29	Yes	Yes	2	0	7
14	R:R:N219	R:R:P220	36.7289	6.52	Yes	No	0	7	8
15	R:R:P196	R:R:P220	72.0913	7.79	Yes	No	0	7	8
16	R:R:P196	R:R:V488	69.2838	3.53	Yes	No	0	7	6
17	R:R:L197	R:R:V488	66.2321	4.47	Yes	No	7	9	6
18	R:R:C213	R:R:L197	65.3957	4.76	No	Yes	0	9	9
19	R:R:C213	R:R:Q192	64.4194	3.05	No	No	0	9	4
20	L:L:?1	R:R:F484	37.3897	13.02	Yes	Yes	0	0	6
21	R:R:F484	R:R:P220	35.855	7.22	Yes	No	0	6	8
22	R:R:Q192	R:R:R199	63.9306	15.19	No	No	0	4	4
23	R:R:G212	R:R:R199	62.9517	4.5	No	No	0	7	4
24	R:R:G212	R:R:W206	62.4616	8.44	No	No	0	7	4
25	R:R:P203	R:R:W206	61.4802	12.16	No	No	0	4	4
26	R:R:N202	R:R:P203	60.9888	4.89	Yes	No	0	5	4
27	R:R:N202	R:R:S205	20.683	8.94	Yes	Yes	3	5	7
28	R:R:D298	R:R:N202	21.2003	8.08	Yes	Yes	3	7	5
29	R:R:K204	R:R:N202	18.6154	4.2	No	Yes	0	3	5
30	R:R:K204	R:R:R296	18.1062	6.19	No	Yes	0	3	6
31	R:R:R296	R:R:S205	18.1127	6.59	Yes	Yes	3	6	7
32	R:R:D298	R:R:R296	18.1204	4.76	Yes	Yes	3	7	6
33	R:R:R296	R:R:T307	23.2969	6.47	Yes	No	3	6	6
34	R:R:E305	R:R:T307	21.748	11.29	No	No	3	7	6
35	R:R:C314	R:R:E305	20.1962	10.64	No	No	3	9	7
36	R:R:C314	R:R:C390	37.2983	7.28	No	No	0	9	9
37	R:R:C390	R:R:G383	34.1924	3.92	No	No	0	9	8
38	R:R:G383	R:R:V294	31.0861	5.52	No	No	0	8	8
39	R:R:C217	R:R:V294	12.4395	3.42	No	No	0	9	8
40	R:R:E310	R:R:R296	29.5094	10.47	Yes	Yes	3	8	6
41	R:R:E310	R:R:R302	26.4117	4.65	Yes	Yes	3	8	6
42	R:R:C314	R:R:R302	20.2073	11.14	No	Yes	3	9	6
43	R:R:F318	R:R:V392	21.075	3.93	Yes	Yes	2	9	9
44	R:R:F318	R:R:Y322	20.6106	9.28	Yes	Yes	2	9	9
45	R:R:T372	R:R:Y322	74.1848	6.24	No	Yes	0	9	9
46	R:R:T372	R:R:Y323	73.4797	3.75	No	No	0	9	8
47	R:R:W365	R:R:Y323	23.5588	7.72	Yes	No	0	9	8
48	R:R:W365	R:R:Y269	16.5831	3.86	Yes	Yes	6	9	8
49	R:R:F268	R:R:Y269	14.2543	9.28	Yes	Yes	0	8	8
50	R:R:F268	R:R:L249	11.053	4.87	Yes	No	0	8	6
51	R:R:F275	R:R:L249	10.2549	3.65	Yes	No	0	5	6
52	R:R:I375	R:R:V392	19.6583	12.29	Yes	Yes	2	7	9
53	R:R:I375	R:R:Y322	19.6005	8.46	Yes	Yes	2	7	9
54	R:R:F403	R:R:Y322	37.8603	5.16	Yes	Yes	2	8	9
55	R:R:P368	R:R:Y323	51.0882	6.95	No	No	0	9	8
56	R:R:L367	R:R:P368	50.3321	1.64	No	No	0	5	9
57	R:R:L367	S:S:S366	49.1967	1.5	No	No	0	5	7
58	S:S:L362	S:S:S366	48.8218	1.5	No	No	0	5	7
59	R:R:F418	S:S:L362	47.702	7.31	Yes	No	0	8	5
60	R:R:F418	R:R:T336	38.5991	5.19	Yes	Yes	0	8	7
61	R:R:L419	R:R:T336	24.4878	7.37	No	Yes	0	7	7
62	R:R:F457	R:R:L419	24.0888	19.49	No	No	0	4	7
63	R:R:F457	R:R:W339	23.6903	6.01	No	Yes	0	4	9
64	R:R:L452	R:R:W339	14.8642	5.69	No	Yes	0	8	9
65	R:R:L452	R:R:W535	13.25	4.56	No	Yes	0	8	9
66	R:R:I293	R:R:V294	15.5483	3.07	No	No	0	8	8
67	R:R:F332	R:R:T336	14.4486	5.19	No	Yes	0	9	7
68	S:S:F403	S:S:Y322	23.6464	5.16	Yes	Yes	2	8	9
69	S:S:T372	S:S:Y322	20.0946	6.24	No	Yes	0	9	9
70	S:S:T372	S:S:Y323	19.7391	4.99	No	Yes	0	9	8
71	S:S:W365	S:S:Y323	18.6698	6.75	Yes	Yes	0	9	8
72	S:S:G456	S:S:L335	10.514	1.71	No	No	0	7	8
73	S:S:G456	S:S:L419	10.4076	1.71	No	No	0	7	7
74	S:S:F484	S:S:V488	10.87	3.93	Yes	No	0	6	6
75	M:M:?1	S:S:W281	12.5588	8.69	Yes	Yes	1	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:?1	S:S:N219	6.99	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:W281	8.69	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:D384	7.6	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:S387	4.58	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:F391	5.58	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:Y394	11.93	1	Yes	Yes	0	5	0	1
M:M:?1	S:S:R400	8.65	1	Yes	No	0	9	0	1
M:M:?1	S:S:Q477	7.45	1	Yes	Yes	0	6	0	1
M:M:?1	S:S:F484	18.59	1	Yes	Yes	0	6	0	1
M:M:?1	S:S:P513	12.53	1	Yes	No	0	8	0	1
M:M:?1	S:S:E518	28.32	1	Yes	No	0	7	0	1
M:M:?1	S:S:N521	4.89	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:L522	5.63	1	Yes	No	0	7	0	1
S:S:F484	S:S:I215	5.02	0	Yes	No	6	5	1	2
S:S:N219	S:S:P220	4.89	1	Yes	No	7	8	1	2
S:S:L221	S:S:N219	4.12	0	No	Yes	6	7	2	1
S:S:F222	S:S:N219	8.46	1	Yes	Yes	6	7	2	1
S:S:D384	S:S:N219	5.39	1	Yes	Yes	8	7	1	1
S:S:N219	S:S:V386	4.43	1	Yes	Yes	7	5	1	2
S:S:F484	S:S:P220	7.22	0	Yes	No	6	8	1	2
S:S:F484	S:S:L221	8.53	0	Yes	No	6	6	1	2
S:S:F222	S:S:V386	5.24	1	Yes	Yes	6	5	2	2
S:S:F222	S:S:P513	7.22	1	Yes	No	6	8	2	1
S:S:I234	S:S:W281	5.87	1	Yes	Yes	7	7	2	1
S:S:V321	S:S:W281	7.36	1	No	Yes	8	7	2	1
S:S:I389	S:S:W281	11.74	1	Yes	Yes	9	7	2	1
S:S:L522	S:S:W281	4.56	1	No	Yes	7	7	1	1
S:S:M525	S:S:W281	4.65	1	No	Yes	5	7	2	1
S:S:F526	S:S:W281	10.02	1	Yes	Yes	9	7	2	1
S:S:I389	S:S:V321	6.14	1	Yes	No	9	8	2	2
S:S:D384	S:S:V386	7.3	1	Yes	Yes	8	5	1	2
S:S:D384	S:S:S387	7.36	1	Yes	Yes	8	8	1	1
S:S:D384	S:S:Y394	9.2	1	Yes	Yes	8	5	1	1
S:S:I389	S:S:S387	4.64	1	Yes	Yes	9	8	2	1
S:S:S387	S:S:Y394	6.36	1	Yes	Yes	8	5	1	1
S:S:F391	S:S:I389	3.77	1	Yes	Yes	8	9	1	2
S:S:F391	S:S:Y394	9.28	1	Yes	Yes	8	5	1	1
S:S:F391	S:S:V404	3.93	1	Yes	No	8	7	1	2
S:S:Q477	S:S:Y397	6.76	1	Yes	Yes	6	3	1	2
S:S:E481	S:S:Y397	7.86	1	No	Yes	5	3	2	2
S:S:H470	S:S:R400	11.28	0	No	No	7	9	2	1
S:S:D473	S:S:R400	10.72	0	No	No	8	9	2	1
S:S:H470	S:S:V404	6.92	0	No	No	7	7	2	2
S:S:N521	S:S:T466	5.85	0	Yes	No	8	8	1	2
S:S:C469	S:S:N521	6.3	0	No	Yes	7	8	2	1
S:S:H470	S:S:N521	14.03	0	No	Yes	7	8	2	1
S:S:D473	S:S:W480	5.58	0	No	Yes	8	9	2	2
S:S:D473	S:S:E518	11.69	0	No	No	8	7	2	1
S:S:Q477	S:S:W480	5.48	1	Yes	Yes	6	9	1	2
S:S:E481	S:S:Q477	7.65	1	No	Yes	5	6	2	1
S:S:P513	S:S:W480	17.57	0	No	Yes	8	9	1	2
S:S:F484	S:S:V488	3.93	0	Yes	No	6	6	1	2
S:S:F526	S:S:L522	4.87	1	Yes	No	9	7	2	1
S:S:F526	S:S:M525	11.2	1	Yes	No	9	5	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N219	6.29	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:M230	4.32	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:W281	7.53	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:D384	7.6	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:S387	4.58	2	Yes	No	0	8	0	1
L:L:?1	R:R:F391	4.96	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y394	11.93	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:K395	4.31	2	Yes	No	0	3	0	1
L:L:?1	R:R:R400	8.04	2	Yes	No	0	9	0	1
L:L:?1	R:R:Q477	8.81	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:F484	13.02	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:P513	11.7	2	Yes	No	0	8	0	1
L:L:?1	R:R:E518	25.62	2	Yes	No	0	7	0	1
L:L:?1	R:R:N521	5.59	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:L522	5.63	2	Yes	No	0	7	0	1
R:R:F484	R:R:I215	5.02	0	Yes	No	6	5	1	2
R:R:N219	R:R:P220	6.52	2	Yes	No	7	8	1	2
R:R:L221	R:R:N219	5.49	2	Yes	Yes	6	7	2	1
R:R:F222	R:R:N219	8.46	2	Yes	Yes	6	7	2	1
R:R:D384	R:R:N219	5.39	2	Yes	Yes	8	7	1	1
R:R:N219	R:R:V386	4.43	2	Yes	Yes	7	5	1	2
R:R:F484	R:R:P220	7.22	0	Yes	No	6	8	1	2
R:R:F222	R:R:L221	4.87	2	Yes	Yes	6	6	2	2
R:R:F484	R:R:L221	4.87	0	Yes	Yes	6	6	1	2
R:R:F222	R:R:V386	5.24	2	Yes	Yes	6	5	2	2
R:R:F222	R:R:P513	8.67	2	Yes	No	6	8	2	1
R:R:F222	R:R:L515	13.4	2	Yes	No	6	5	2	2
R:R:I234	R:R:M230	5.83	0	No	Yes	7	7	2	1
R:R:L515	R:R:M230	5.65	0	No	Yes	5	7	2	1
R:R:K519	R:R:M230	4.32	0	No	Yes	7	7	2	1
R:R:I234	R:R:W281	5.87	0	No	Yes	7	7	2	1
R:R:V321	R:R:W281	8.58	2	No	Yes	8	7	2	1
R:R:I389	R:R:W281	12.92	2	No	Yes	9	7	2	1
R:R:L522	R:R:W281	5.69	2	No	Yes	7	7	1	1
R:R:F526	R:R:W281	8.02	2	Yes	Yes	9	7	2	1
R:R:I389	R:R:V321	6.14	2	No	No	9	8	2	2
R:R:D382	R:R:Y394	5.75	0	No	Yes	9	5	2	1
R:R:D382	R:R:K395	4.15	0	No	No	9	3	2	1
R:R:D384	R:R:V386	8.76	2	Yes	Yes	8	5	1	2
R:R:D384	R:R:S387	7.36	2	Yes	No	8	8	1	1
R:R:D384	R:R:Y394	9.2	2	Yes	Yes	8	5	1	1
R:R:S387	R:R:Y394	6.36	2	No	Yes	8	5	1	1
R:R:F391	R:R:I389	3.77	2	Yes	No	8	9	1	2
R:R:F391	R:R:V392	3.93	2	Yes	Yes	8	9	1	2
R:R:F391	R:R:Y394	8.25	2	Yes	Yes	8	5	1	1
R:R:F391	R:R:V404	5.24	2	Yes	No	8	7	1	2
R:R:K395	R:R:N396	8.39	0	No	No	3	7	1	2
R:R:Q477	R:R:Y397	6.76	2	Yes	Yes	6	3	1	2
R:R:E481	R:R:Y397	6.73	2	No	Yes	5	3	2	2
R:R:H470	R:R:R400	10.16	0	No	No	7	9	2	1
R:R:D473	R:R:R400	11.91	0	No	No	8	9	2	1
R:R:H470	R:R:V404	6.92	0	No	No	7	7	2	2
R:R:N521	R:R:T466	4.39	0	Yes	No	8	8	1	2
R:R:C469	R:R:N521	6.3	0	No	Yes	7	8	2	1
R:R:H470	R:R:N521	14.03	0	No	Yes	7	8	2	1
R:R:D473	R:R:W480	5.58	0	No	Yes	8	9	2	2
R:R:D473	R:R:E518	11.69	0	No	No	8	7	2	1
R:R:Q477	R:R:W480	5.48	2	Yes	Yes	6	9	1	2
R:R:E481	R:R:Q477	11.47	2	No	Yes	5	6	2	1
R:R:P513	R:R:W480	22.97	0	No	Yes	8	9	1	2
R:R:F526	R:R:L522	7.31	2	Yes	No	9	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	4JKV_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.73
Number of Linked Nodes	641
Number of Links	776
Number of Hubs	115
Number of Links mediated by Hubs	432
Number of Communities	19
Number of Nodes involved in Communities	165
Number of Links involved in Communities	245

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	728850
Length Of Smallest Path	3
Average Path Length	24.8305
Length of Longest Path	50
Minimum Path Strength	1.19
Average Path Strength	6.42447
Maximum Path Strength	23.455
Minimum Path Correlation	0.7
Average Path Correlation	0.965977
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	49.4231
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.0212
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • patched binding • protein binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein serine/threonine kinase activity • enzyme regulator activity • catalytic activity, acting on a protein • kinase activity • cyclic nucleotide-dependent protein kinase activity • protein kinase activity • cAMP-dependent protein kinase activity • transferase activity • enzyme inhibitor activity • protein kinase regulator activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • cAMP-dependent protein kinase regulator activity • protein kinase inhibitor activity • molecular function inhibitor activity • molecular function regulator activity • catalytic activity • cAMP-dependent protein kinase inhibitor activity • protein serine/threonine kinase inhibitor activity • kinase inhibitor activity • kinase regulator activity • molecular sequestering activity • protein sequestering activity • sterol binding • oxysterol binding • steroid binding • lipid binding • protein kinase A catalytic subunit binding • protein kinase A binding • kinase binding • enzyme binding • protein kinase binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • response to sterol • response to stimulus • response to lipid • response to alcohol • response to oxygen-containing compound • response to cholesterol • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • response to sterol • response to stimulus • response to lipid • response to alcohol • response to oxygen-containing compound • response to cholesterol • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to chemical • cellular response to lipid • cellular response to sterol • cellular response to cholesterol • developmental process • cellular developmental process • cell differentiation • cell fate specification • cell fate commitment • neuroblast proliferation • multicellular organismal process • cell population proliferation • nervous system development • generation of neurons • neurogenesis • multicellular organism development • anatomical structure development • neural precursor cell proliferation • system development • pattern specification process • digestive system development • tube development • midgut development • digestive tract development • regulation of protein stability • biological regulation • regulation of biological quality • protein stabilization • central nervous system development • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • mammary gland epithelial cell differentiation • epithelium development • mammary gland development • gland development • animal organ development • tissue development • epithelial cell differentiation • mammary gland epithelium development • regulation of biological process • signaling • cell-cell signaling • epithelial-mesenchymal cell signaling • cell communication • muscle cell migration • myoblast migration • cell migration • cell motility • regulation of biosynthetic process • regulation of cellular process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • anatomical structure morphogenesis • pancreas morphogenesis • pancreas development • animal organ morphogenesis • apoptotic process • cell death • programmed cell death • regulation of protein modification process • regulation of protein phosphorylation • negative regulation of biological process • negative regulation of phosphate metabolic process • regulation of primary metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • negative regulation of cellular process • protein metabolic process • protein modification process • phosphorus metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • negative regulation of phosphorylation • cerebellum morphogenesis • cerebellar cortex morphogenesis • head development • hindbrain morphogenesis • brain development • cerebellar cortex development • cerebellum development • metencephalon development • hindbrain development • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • nucleocytoplasmic transport • transport • nuclear transport • intracellular transport • protein localization to nucleus • establishment of localization • localization • import into nucleus • establishment of protein localization to organelle • protein transport • cellular macromolecule localization • macromolecule localization • protein localization to organelle • establishment of localization in cell • protein import into nucleus • intracellular protein transport • epidermis development • molting cycle process • hair cycle • epidermis morphogenesis • morphogenesis of an epithelium • tissue morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • hair cycle process • hair follicle morphogenesis • regulation of localization • regulation of protein localization • positive regulation of nucleocytoplasmic transport • positive regulation of establishment of protein localization • regulation of protein localization to nucleus • positive regulation of protein transport • regulation of protein import into nucleus • positive regulation of intracellular transport • regulation of intracellular transport • regulation of transport • positive regulation of protein localization to nucleus • regulation of establishment of protein localization • positive regulation of protein import into nucleus • regulation of nucleocytoplasmic transport • regulation of protein transport • positive regulation of transport • regulation of cellular localization • positive regulation of protein localization • regulation of intracellular protein transport • positive regulation of intracellular protein transport • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • forebrain development • pallium development • cerebral cortex development • telencephalon development • astrocyte differentiation • cell development • astrocyte activation • glial cell development • astrocyte development • gliogenesis • response to stress • defense response • cell activation • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • brain morphogenesis • forebrain morphogenesis • neural tube development • regionalization • dorsal/ventral pattern formation • dorsal/ventral neural tube patterning • neural tube patterning • endocrine system development • type B pancreatic cell development • epithelial cell development • endocrine pancreas development • enteroendocrine cell differentiation • type B pancreatic cell differentiation • RNA metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • transcription by RNA polymerase II • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • negative regulation of DNA-templated transcription • negative regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • multicellular organism growth • developmental growth • growth • positive regulation of DNA-templated transcription • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • heart morphogenesis • embryonic heart tube development • tube morphogenesis • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • heart development • embryonic morphogenesis • determination of heart left/right asymmetry • circulatory system development • left/right pattern formation • regulation of somatic stem cell population maintenance • regulation of developmental process • regulation of stem cell population maintenance • stem cell population maintenance • somatic stem cell population maintenance • regulation of multicellular organismal process • maintenance of cell number • ossification • osteoblast differentiation • cell surface receptor signaling pathway • smoothened signaling pathway • signal transduction • myotube cell development • skeletal muscle fiber development • skeletal muscle tissue development • muscle cell differentiation • myotube differentiation • striated muscle tissue development • muscle structure development • skeletal muscle organ development • striated muscle cell development • muscle cell development • muscle tissue development • muscle organ development • striated muscle cell differentiation • cardiac atrium morphogenesis • cardiac chamber morphogenesis • cardiac atrium development • cardiac septum development • cardiac septum morphogenesis • cardiac chamber development • atrial septum morphogenesis • atrial septum development • mesonephric epithelium development • kidney epithelium development • branching morphogenesis of an epithelial tube • nephron tubule morphogenesis • regulation of kidney development • regulation of branching involved in ureteric bud morphogenesis • positive regulation of developmental process • nephron development • regulation of morphogenesis of a branching structure • regulation of animal organ morphogenesis • positive regulation of multicellular organismal process • mesonephric tubule development • renal tubule morphogenesis • nephron morphogenesis • nephron epithelium morphogenesis • nephron tubule development • renal system development • ureteric bud morphogenesis • positive regulation of morphogenesis of an epithelium • branching involved in ureteric bud morphogenesis • renal tubule development • regulation of morphogenesis of an epithelium • regulation of anatomical structure morphogenesis • nephron epithelium development • ureteric bud development • mesonephros development • kidney morphogenesis • morphogenesis of a branching structure • positive regulation of branching involved in ureteric bud morphogenesis • mesonephric tubule morphogenesis • kidney development • morphogenesis of a branching epithelium • odontogenesis of dentin-containing tooth • odontogenesis • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • negative regulation of apoptotic process • ventral midline determination • ventral midline development • central nervous system neuron differentiation • neuron differentiation • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of smoothened signaling pathway • regulation of smoothened signaling pathway • regulation of signaling • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • regulation of cell differentiation • regulation of epithelial cell differentiation • negative regulation of cell differentiation • regulation of multicellular organismal development • negative regulation of epithelial cell differentiation • negative regulation of developmental process • spinal cord dorsal/ventral patterning • spinal cord development • spinal cord patterning • positive regulation of mesenchymal cell proliferation • positive regulation of cell population proliferation • regulation of mesenchymal cell proliferation • regulation of cell population proliferation • mesenchymal cell proliferation • positive regulation of epithelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • diencephalon development • thalamus development • stem cell development • neural crest cell differentiation • neural crest cell development • mesenchyme development • mesenchymal cell migration • stem cell differentiation • ameboidal-type cell migration • mesenchymal cell differentiation • neural crest cell migration • commissural neuron axon guidance • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon guidance • axon development • cell morphogenesis involved in neuron differentiation • neuron projection guidance • neuron development • left/right axis specification • axis specification • regulation of heart morphogenesis • blood vessel morphogenesis • vasculogenesis • vasculature development • blood vessel development • mesenchymal to epithelial transition involved in renal vesicle formation • renal vesicle morphogenesis • metanephric renal vesicle morphogenesis • renal vesicle development • metanephros development • metanephric renal vesicle formation • metanephros morphogenesis • metanephric nephron development • mesenchymal to epithelial transition involved in metanephric renal vesicle formation • mesenchymal to epithelial transition involved in metanephros morphogenesis • epithelial cell differentiation involved in kidney development • mesenchymal to epithelial transition • metanephric nephron morphogenesis • cell differentiation involved in metanephros development • cell differentiation involved in kidney development • anatomical structure formation involved in morphogenesis • renal vesicle formation • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of growth • regulation of developmental growth • positive regulation of organ growth • organ growth • positive regulation of growth • regulation of organ growth • positive regulation of developmental growth • regulation of multicellular organism growth • positive regulation of multicellular organism growth • dentate gyrus development • hippocampus development • limbic system development • smooth muscle tissue development • regulation of molecular function • regulation of DNA binding • regulation of binding • negative regulation of binding • negative regulation of molecular function • negative regulation of DNA binding • response to inositol • negative regulation of gene expression • regulation of hair cycle • regulation of hair follicle development • negative regulation of hair follicle development • negative regulation of multicellular organismal process • detection of stimulus • contact inhibition • detection of cell density • detection of biotic stimulus • response to biotic stimulus • lateral mesoderm development • determination of left/right asymmetry in lateral mesoderm • mesoderm development • dopaminergic neuron differentiation • positive regulation of nervous system development • regulation of neuroblast proliferation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • anterior/posterior pattern specification • somite development • cellular anatomical structure • periplasmic space • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell projection • ciliary tip • cilium
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell projection • ciliary tip • cilium • plasma membrane bounded cell projection • somatodendritic compartment • dendrite • dendritic tree • neuron projection • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • endocytic vesicle membrane • cytoplasm • organelle membrane • endocytic vesicle • Golgi apparatus • endomembrane system • endoplasmic reticulum-Golgi intermediate compartment • non-motile cilium • 9+0 non-motile cilium • microtubule organizing center • cytoskeleton • membraneless organelle • centriole • intracellular membraneless organelle • microtubule cytoskeleton • cell periphery • plasma membrane • ciliary membrane • plasma membrane region • cell projection membrane • endosome • late endosome • endoplasmic reticulum
SCOP2	Domain Identifier	• Cytochromes • G protein-coupled receptor-like
SCOP2	Family Identifier	• Cytochromes • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	1KS
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	1KS
Name	Taladegib
Synonyms	Taladegib
Identifier
Formula	C26 H24 F4 N6 O
Molecular Weight	512.502
SMILES
PubChem	49848070
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	0
Total Bonds	65
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>4JKV_poly_Chain_R S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R L G E P T S N E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T K A T L L I W R R T W C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	10.1038/s41467-022-32125-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	10.1126/sciadv.abm5563
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.14	2020-09-30	10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.14	2020-09-30	10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	10.1038/s41589-020-0646-2
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	10.1038/s41586-019-1355-4
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	10.1038/s41586-019-1286-0
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	10.1016/j.cell.2018.04.029
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	10.1016/j.cell.2018.04.029
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	10.1038/ncomms15383
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	10.1038/ncomms15383
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	10.1038/nature18934
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	10.1038/nature18934
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	10.1038/ncomms5355
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	10.1038/ncomms4309
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	10.1038/ncomms5355
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	10.1038/nature12167
	4JKV (Multimeric)	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-		2.45	2013-04-24	10.1038/nature12167

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Download 4JKV_poly.zip

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