psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q192	R:R:R199	15.19	No	No	0	4	4
2	R:R:C193	R:R:C213	7.28	No	No	0	9	9
3	R:R:P196	R:R:Q216	6.32	Yes	No	0	7	7
4	R:R:P196	R:R:P220	7.79	Yes	No	0	7	8
5	R:R:P196	R:R:Y487	6.95	Yes	No	0	7	4
6	R:R:L197	R:R:Y207	4.69	Yes	Yes	8	9	7
7	R:R:L197	R:R:V210	4.47	Yes	No	0	9	5
8	R:R:C213	R:R:L197	4.76	No	Yes	0	9	9
9	R:R:L197	R:R:V488	4.47	Yes	No	8	9	6
10	R:R:D201	R:R:R199	5.96	No	No	0	5	4
11	R:R:G212	R:R:R199	4.5	No	No	0	7	4
12	R:R:S205	R:R:T200	6.4	Yes	No	3	7	6
13	R:R:D298	R:R:T200	11.56	Yes	No	3	7	6
14	R:R:N202	R:R:P203	4.89	Yes	No	0	5	4
15	R:R:K204	R:R:N202	4.2	No	Yes	0	3	5
16	R:R:N202	R:R:S205	8.94	Yes	Yes	3	5	7
17	R:R:D298	R:R:N202	8.08	Yes	Yes	3	7	5
18	R:R:P203	R:R:W206	12.16	No	No	0	4	4
19	R:R:K204	R:R:R296	6.19	No	Yes	0	3	6
20	R:R:R296	R:R:S205	6.59	Yes	Yes	3	6	7
21	R:R:D298	R:R:S205	8.83	Yes	Yes	3	7	7
22	R:R:S205	R:R:T300	9.59	Yes	Yes	3	7	7
23	R:R:E211	R:R:W206	6.54	No	No	0	5	4
24	R:R:G212	R:R:W206	8.44	No	No	0	7	4
25	R:R:E208	R:R:Y207	12.35	No	Yes	8	4	7
26	R:R:R485	R:R:Y207	4.12	No	Yes	8	5	7
27	R:R:V488	R:R:Y207	8.83	No	Yes	8	6	7
28	R:R:E208	R:R:R485	17.45	No	No	8	4	5
29	R:R:E208	R:R:L489	3.98	No	No	8	4	4
30	R:R:I215	R:R:M301	5.83	No	No	0	5	4
31	R:R:F484	R:R:I215	5.02	Yes	No	0	6	5
32	R:R:C217	R:R:C295	7.28	No	No	0	9	9
33	R:R:E224	R:R:Q218	5.1	No	No	0	4	5
34	R:R:H227	R:R:Q218	21.02	Yes	No	1	7	5
35	R:R:Q218	R:R:S385	4.33	No	No	1	5	7
36	R:R:N219	R:R:P220	6.52	Yes	No	0	7	8
37	R:R:L221	R:R:N219	5.49	Yes	Yes	1	6	7
38	R:R:F222	R:R:N219	8.46	Yes	Yes	1	6	7
39	R:R:D384	R:R:N219	5.39	Yes	Yes	1	8	7
40	R:R:N219	R:R:V386	4.43	Yes	Yes	1	7	5
41	L:L:?1	R:R:N219	6.29	Yes	Yes	1	0	7
42	R:R:F484	R:R:P220	7.22	Yes	No	0	6	8
43	R:R:F222	R:R:L221	4.87	Yes	Yes	1	6	6
44	R:R:F484	R:R:L221	4.87	Yes	Yes	0	6	6
45	R:R:I509	R:R:L221	4.28	No	Yes	0	4	6
46	R:R:E226	R:R:F222	5.83	No	Yes	1	8	6
47	R:R:F222	R:R:V386	5.24	Yes	Yes	1	6	5
48	R:R:F222	R:R:R512	13.9	Yes	No	1	6	6
49	R:R:F222	R:R:P513	8.67	Yes	No	0	6	8
50	R:R:F222	R:R:L515	13.4	Yes	No	0	6	5
51	R:R:E226	R:R:T223	14.11	No	No	0	8	5
52	R:R:E224	R:R:Q228	6.37	No	No	0	4	3
53	R:R:E226	R:R:R512	10.47	No	No	1	8	6
54	R:R:H227	R:R:H231	7.17	Yes	No	1	7	7
55	R:R:H227	R:R:S385	6.97	Yes	No	1	7	7
56	R:R:H227	R:R:V386	9.69	Yes	Yes	1	7	5
57	R:R:D229	R:R:K519	6.91	No	No	0	6	7
58	R:R:I234	R:R:M230	5.83	No	Yes	0	7	7
59	R:R:L515	R:R:M230	5.65	No	Yes	0	5	7
60	R:R:K519	R:R:M230	4.32	No	Yes	0	7	7
61	L:L:?1	R:R:M230	4.32	Yes	Yes	0	0	7
62	R:R:H231	R:R:Q284	3.71	No	Yes	1	7	9
63	R:R:H231	R:R:R290	28.21	No	No	1	7	9
64	R:R:F237	R:R:Y233	14.44	No	No	0	4	6
65	R:R:K519	R:R:Y233	26.27	No	No	0	7	6
66	R:R:I234	R:R:W281	5.87	No	Yes	0	7	7
67	R:R:F285	R:R:I234	5.02	No	No	0	8	7
68	R:R:A235	R:R:F285	6.93	No	No	0	5	8
69	R:R:F237	R:R:F523	4.29	No	No	0	4	6
70	R:R:F237	R:R:F526	9.65	No	Yes	0	4	9
71	R:R:G238	R:R:L282	5.13	No	No	0	7	7
72	R:R:F526	R:R:G238	4.52	Yes	No	0	9	7
73	R:R:F526	R:R:T241	10.38	Yes	No	0	9	7
74	R:R:I530	R:R:T241	6.08	No	No	0	7	7
75	R:R:G242	R:R:S278	3.71	No	No	0	4	8
76	R:R:C244	R:R:S533	5.16	No	No	0	6	9
77	R:R:N271	R:R:T245	5.85	No	No	0	9	8
78	R:R:F275	R:R:T245	5.19	Yes	No	0	5	8
79	R:R:F275	R:R:L246	7.31	Yes	No	0	5	6
80	R:R:F247	R:R:T251	7.78	No	Yes	10	8	9
81	R:R:F247	R:R:V536	3.93	No	Yes	10	8	8
82	R:R:F247	R:R:W545	6.01	No	Yes	10	8	9
83	R:R:N271	R:R:T248	11.7	No	No	0	9	8
84	R:R:S533	R:R:T248	4.8	No	No	0	9	8
85	R:R:T248	R:R:V536	11.11	No	Yes	0	8	8
86	R:R:F268	R:R:L249	4.87	Yes	No	0	8	6
87	R:R:T251	R:R:V536	11.11	Yes	Yes	10	9	8
88	R:R:T251	R:R:T541	7.85	Yes	No	10	9	8
89	R:R:T251	R:R:W545	9.7	Yes	Yes	10	9	9
90	R:R:F252	R:R:S259	5.28	No	No	0	9	8
91	R:R:F252	R:R:F268	17.15	No	Yes	0	9	8
92	R:R:D255	R:R:N258	8.08	No	No	0	8	8
93	R:R:D255	R:R:S259	7.36	No	No	0	8	8
94	R:R:D255	R:R:I544	9.8	No	No	0	8	6
95	R:R:N260	R:R:W256	22.6	No	No	0	7	7
96	R:R:F268	R:R:W256	10.02	Yes	No	0	8	7
97	R:R:N260	R:R:V265	7.39	No	No	0	7	8
98	R:R:K356	R:R:R261	6.19	No	No	0	8	7
99	R:R:V265	R:R:Y262	8.83	No	Yes	0	8	9
100	R:R:I266	R:R:Y262	4.84	No	Yes	0	8	9
101	R:R:G355	R:R:Y262	4.35	No	Yes	0	6	9
102	R:R:F360	R:R:Y262	7.22	Yes	Yes	0	9	9
103	R:R:L452	R:R:P263	4.93	No	No	0	8	9
104	R:R:V265	R:R:Y269	3.79	No	Yes	0	8	8
105	R:R:I266	R:R:W331	7.05	No	Yes	6	8	9
106	R:R:I266	R:R:V334	4.61	No	No	6	8	7
107	R:R:L267	R:R:L335	4.15	No	No	0	8	8
108	R:R:L267	R:R:M532	4.24	No	Yes	0	8	8
109	R:R:L267	R:R:W535	17.08	No	Yes	0	8	9
110	R:R:F268	R:R:Y269	9.28	Yes	Yes	0	8	8
111	R:R:W331	R:R:Y269	18.33	Yes	Yes	6	9	8
112	R:R:H361	R:R:Y269	9.8	No	Yes	6	9	8
113	R:R:W365	R:R:Y269	3.86	Yes	Yes	6	9	8
114	R:R:C273	R:R:G328	3.92	No	No	0	9	8
115	R:R:F274	R:R:T528	7.78	No	No	0	9	7
116	R:R:F274	R:R:G529	9.03	No	No	0	9	9
117	R:R:F275	R:R:I279	6.28	Yes	No	0	5	5
118	R:R:V321	R:R:W281	8.58	No	Yes	1	8	7
119	R:R:I389	R:R:W281	12.92	No	Yes	1	9	7
120	R:R:L522	R:R:W281	5.69	No	Yes	1	7	7
121	R:R:F526	R:R:W281	8.02	Yes	Yes	1	9	7
122	L:L:?1	R:R:W281	7.53	Yes	Yes	1	0	7
123	R:R:F285	R:R:Q284	17.57	No	Yes	0	8	9
124	R:R:Q284	R:R:R290	17.52	Yes	No	1	9	9
125	R:R:G388	R:R:Q284	8.22	No	Yes	1	9	9
126	R:R:G288	R:R:R291	7.51	No	No	0	6	5
127	R:R:G388	R:R:R290	4.5	No	No	1	9	9
128	R:R:E292	R:R:T311	11.29	No	No	3	5	7
129	R:R:E292	R:R:S313	10.06	No	No	3	5	7
130	R:R:I293	R:R:I317	8.83	No	No	0	8	7
131	R:R:G383	R:R:V294	5.52	No	No	0	8	8
132	R:R:D298	R:R:R296	4.76	Yes	Yes	3	7	6
133	R:R:R296	R:R:T300	3.88	Yes	Yes	3	6	7
134	R:R:R296	R:R:T307	6.47	Yes	No	3	6	6
135	R:R:E310	R:R:R296	10.47	Yes	Yes	3	8	6
136	R:R:D298	R:R:T300	13.01	Yes	Yes	3	7	7
137	R:R:L303	R:R:M301	7.07	No	No	0	3	4
138	R:R:E305	R:R:R302	12.79	No	Yes	3	7	6
139	R:R:E310	R:R:R302	4.65	Yes	Yes	3	8	6
140	R:R:R302	R:R:T311	5.17	Yes	No	3	6	7
141	R:R:C314	R:R:R302	11.14	No	Yes	3	9	6
142	R:R:D382	R:R:L303	5.43	No	No	0	9	3
143	R:R:E305	R:R:T307	11.29	No	No	3	7	6
144	R:R:C314	R:R:E305	10.64	No	No	3	9	7
145	R:R:P306	R:R:V315	5.3	No	No	0	5	7
146	R:R:L376	R:R:P306	6.57	No	No	0	8	5
147	R:R:E310	R:R:T307	4.23	Yes	No	3	8	6
148	R:R:N309	R:R:S308	4.47	No	No	0	6	8
149	R:R:S313	R:R:T311	6.4	No	No	3	7	7
150	R:R:C314	R:R:C390	7.28	No	No	0	9	9
151	R:R:F318	R:R:Y322	9.28	Yes	Yes	1	9	9
152	R:R:F318	R:R:I375	10.05	Yes	Yes	1	9	7
153	R:R:F318	R:R:V381	15.73	Yes	No	0	9	8
154	R:R:F318	R:R:V392	3.93	Yes	Yes	1	9	9
155	R:R:T372	R:R:V319	4.76	No	No	0	9	7
156	R:R:I389	R:R:V321	6.14	No	No	1	9	8
157	R:R:M326	R:R:Y322	13.17	No	Yes	0	8	9
158	R:R:L371	R:R:Y322	7.03	No	Yes	0	8	9
159	R:R:T372	R:R:Y322	6.24	No	Yes	0	9	9
160	R:R:I375	R:R:Y322	8.46	Yes	Yes	1	7	9
161	R:R:F403	R:R:Y322	5.16	Yes	Yes	1	8	9
162	R:R:W365	R:R:Y323	7.72	Yes	No	0	9	8
163	R:R:P368	R:R:Y323	6.95	No	No	0	9	8
164	R:R:T372	R:R:Y323	3.75	No	No	0	9	8
165	R:R:A327	R:R:P368	3.74	No	No	0	9	9
166	R:R:V329	R:R:V411	9.62	No	No	0	6	5
167	R:R:V334	R:R:W331	6.13	No	Yes	6	7	9
168	R:R:F360	R:R:W331	4.01	Yes	Yes	6	9	9
169	R:R:H361	R:R:W331	10.58	No	Yes	6	9	9
170	R:R:T364	R:R:W331	19.41	No	Yes	6	9	9
171	R:R:W331	R:R:W365	14.99	Yes	Yes	6	9	9
172	R:R:F332	R:R:T336	5.19	No	Yes	0	9	7
173	R:R:F332	R:R:F460	4.29	No	Yes	0	9	5
174	R:R:F332	R:R:V463	3.93	No	No	0	9	7
175	R:R:F360	R:R:V334	9.18	Yes	No	6	9	7
176	R:R:G415	R:R:T336	5.46	No	Yes	0	8	7
177	R:R:F418	R:R:T336	5.19	Yes	Yes	0	8	7
178	R:R:L419	R:R:T336	7.37	No	Yes	0	7	7
179	R:R:T341	R:R:Y337	14.98	No	Yes	4	6	7
180	R:R:Y337	R:R:Y350	4.96	Yes	Yes	4	7	7
181	R:R:F418	R:R:Y337	7.22	Yes	Yes	4	8	7
182	R:R:Y337	S:S:Y359	3.97	Yes	Yes	4	7	7
183	R:R:F343	R:R:W339	11.02	No	Yes	0	9	9
184	R:R:L452	R:R:W339	5.69	No	Yes	0	8	9
185	R:R:G453	R:R:W339	8.44	No	Yes	0	5	9
186	R:R:F457	R:R:W339	6.01	No	Yes	0	4	9
187	R:R:H340	R:R:K344	7.86	Yes	Yes	4	7	6
188	R:R:F418	R:R:H340	5.66	Yes	Yes	4	8	7
189	R:R:H340	R:R:R421	18.05	Yes	Yes	4	7	7
190	R:R:G422	R:R:H340	4.77	No	Yes	0	8	7
191	R:R:H340	R:R:T425	4.11	Yes	No	4	7	7
192	R:R:H340	S:S:Y359	4.36	Yes	Yes	4	7	7
193	R:R:T341	R:R:Y350	8.74	No	Yes	4	6	7
194	R:R:M449	R:R:S342	6.13	No	No	0	9	8
195	R:R:F343	R:R:L426	10.96	No	No	0	9	9
196	R:R:F343	R:R:M449	13.68	No	No	0	9	9
197	R:R:K344	R:R:Y350	4.78	Yes	Yes	4	6	7
198	R:R:K344	R:R:R421	4.95	Yes	Yes	4	6	7
199	R:R:K344	R:R:T425	9.01	Yes	No	4	6	7
200	R:R:A345	R:R:P352	5.61	No	No	0	7	7
201	R:R:Y350	S:S:S358	10.17	Yes	No	0	7	6
202	R:R:Y350	S:S:Y359	4.96	Yes	Yes	4	7	7
203	R:R:Q351	S:S:K356	6.78	No	No	0	7	8
204	R:R:Q351	S:S:S358	4.33	No	No	0	7	6
205	R:R:K356	R:R:P352	8.36	No	No	0	8	7
206	R:R:H361	R:R:W365	9.52	No	Yes	6	9	9
207	R:R:L362	S:S:V414	4.47	No	No	9	5	5
208	R:R:L362	S:S:F418	6.09	No	Yes	9	5	8
209	R:R:T364	R:R:W365	8.49	No	Yes	6	9	9
210	R:R:F369	R:R:V373	5.24	No	No	0	7	7
211	R:R:F369	S:S:L410	4.87	No	Yes	0	7	4
212	R:R:V370	S:S:L367	4.47	No	No	0	5	5
213	R:R:V370	S:S:L371	4.47	No	No	0	5	8
214	R:R:L371	S:S:V370	4.47	No	No	0	8	5
215	R:R:A374	S:S:F403	4.16	No	Yes	0	5	8
216	R:R:I375	R:R:V392	12.29	Yes	Yes	1	7	9
217	R:R:F403	R:R:I375	15.07	Yes	Yes	1	8	7
218	R:R:V378	S:S:Y399	15.14	No	No	0	5	5
219	R:R:N396	R:R:Q380	6.6	No	No	0	7	7
220	R:R:Q380	R:R:Y399	24.8	No	No	0	7	5
221	R:R:D382	R:R:Y394	5.75	No	Yes	0	9	5
222	R:R:D382	R:R:K395	4.15	No	No	0	9	3
223	R:R:C390	R:R:G383	3.92	No	No	0	9	8
224	R:R:D384	R:R:V386	8.76	Yes	Yes	1	8	5
225	R:R:D384	R:R:S387	7.36	Yes	No	1	8	8
226	R:R:D384	R:R:Y394	9.2	Yes	Yes	1	8	5
227	L:L:?1	R:R:D384	7.6	Yes	Yes	1	0	8
228	R:R:S387	R:R:Y394	6.36	No	Yes	1	8	5
229	L:L:?1	R:R:S387	4.58	Yes	No	1	0	8
230	R:R:F391	R:R:I389	3.77	Yes	No	1	8	9
231	R:R:F391	R:R:V392	3.93	Yes	Yes	1	8	9
232	R:R:F391	R:R:Y394	8.25	Yes	Yes	1	8	5
233	R:R:F391	R:R:V404	5.24	Yes	No	0	8	7
234	L:L:?1	R:R:F391	4.96	Yes	Yes	1	0	8
235	R:R:F403	R:R:V392	5.24	Yes	Yes	1	8	9
236	L:L:?1	R:R:Y394	11.93	Yes	Yes	1	0	5
237	R:R:K395	R:R:N396	8.39	No	No	0	3	7
238	L:L:?1	R:R:K395	4.31	Yes	No	0	0	3
239	R:R:R398	R:R:Y397	14.4	No	Yes	0	1	3
240	R:R:Q477	R:R:Y397	6.76	Yes	Yes	1	6	3
241	R:R:A478	R:R:Y397	5.34	No	Yes	0	3	3
242	R:R:E481	R:R:Y397	6.73	No	Yes	1	5	3
243	R:R:Y399	S:S:V378	11.36	No	No	0	5	5
244	R:R:Y399	S:S:Y399	10.92	No	No	0	5	5
245	R:R:H470	R:R:R400	10.16	No	No	0	7	9
246	R:R:D473	R:R:R400	11.91	No	No	0	8	9
247	L:L:?1	R:R:R400	8.04	Yes	No	0	0	9
248	R:R:A401	R:R:F474	4.16	No	No	0	6	6
249	R:R:F403	S:S:F403	6.43	Yes	Yes	1	8	8
250	R:R:H470	R:R:V404	6.92	No	No	0	7	7
251	R:R:F467	R:R:L405	8.53	Yes	No	0	7	8
252	R:R:F471	R:R:L405	7.31	No	No	12	4	8
253	R:R:F474	R:R:L405	6.09	No	No	12	6	8
254	R:R:F467	R:R:I408	5.02	Yes	No	0	7	7
255	R:R:F467	R:R:G409	4.52	Yes	No	0	7	4
256	R:R:F460	R:R:L412	4.87	Yes	Yes	0	5	7
257	R:R:L412	R:R:V463	4.47	Yes	No	0	7	7
258	R:R:L412	R:R:L464	4.15	Yes	No	0	7	4
259	R:R:F467	R:R:L412	4.87	Yes	Yes	0	7	7
260	R:R:V414	S:S:L362	4.47	No	No	0	5	5
261	R:R:F418	R:R:Y417	6.19	Yes	No	4	8	5
262	R:R:R421	R:R:Y417	11.32	Yes	No	4	7	5
263	R:R:Y417	S:S:Y359	8.94	No	Yes	4	5	7
264	R:R:F418	S:S:Y359	9.28	Yes	Yes	4	8	7
265	R:R:F418	S:S:L362	7.31	Yes	No	0	8	5
266	R:R:F457	R:R:L419	19.49	No	No	0	4	7
267	R:R:R421	S:S:Y359	6.17	Yes	Yes	4	7	7
268	R:R:F427	R:R:V423	3.93	No	No	0	7	7
269	R:R:H433	R:R:I429	7.95	Yes	No	0	8	7
270	R:R:I429	R:R:L437	4.28	No	No	0	7	6
271	R:R:K430	R:R:L437	4.23	No	No	0	8	6
272	R:R:H433	R:R:L436	5.14	Yes	No	0	8	6
273	R:R:E439	R:R:S438	4.31	No	Yes	0	5	8
274	R:R:I454	R:R:L450	4.28	No	No	0	6	6
275	R:R:F455	R:R:R451	7.48	Yes	No	11	8	9
276	R:R:R451	R:R:W535	13.99	No	Yes	11	9	9
277	R:R:R451	R:R:T538	3.88	No	No	0	9	8
278	R:R:L452	R:R:W535	4.56	No	Yes	0	8	9
279	R:R:F455	R:R:M532	8.71	Yes	Yes	0	8	8
280	R:R:F455	R:R:T534	5.19	Yes	No	0	8	7
281	R:R:F455	R:R:W535	11.02	Yes	Yes	11	8	9
282	R:R:F462	R:R:L458	4.87	No	No	0	7	6
283	R:R:F462	R:R:T528	6.49	No	No	0	7	7
284	R:R:N521	R:R:T466	4.39	Yes	No	0	8	8
285	R:R:C469	R:R:N521	6.3	No	Yes	0	7	8
286	R:R:H470	R:R:N521	14.03	No	Yes	0	7	8
287	R:R:F471	R:R:F474	5.36	No	No	12	4	6
288	R:R:N476	R:R:Y472	12.79	No	Yes	1	6	7
289	R:R:W480	R:R:Y472	5.79	Yes	Yes	1	9	7
290	R:R:S514	R:R:Y472	3.82	No	Yes	1	7	7
291	R:R:V517	R:R:Y472	13.88	No	Yes	1	6	7
292	R:R:D473	R:R:W480	5.58	No	Yes	0	8	9
293	R:R:D473	R:R:E518	11.69	No	No	0	8	7
294	R:R:F475	R:R:N476	4.83	No	No	0	3	6
295	R:R:N476	R:R:W480	9.04	No	Yes	1	6	9
296	R:R:Q477	R:R:W480	5.48	Yes	Yes	1	6	9
297	R:R:E481	R:R:Q477	11.47	No	Yes	1	5	6
298	L:L:?1	R:R:Q477	8.81	Yes	Yes	1	0	6
299	R:R:E479	R:R:R482	6.98	No	No	0	2	3
300	R:R:E479	R:R:N511	9.2	No	No	0	2	4
301	R:R:N511	R:R:W480	7.91	No	Yes	0	4	9
302	R:R:P513	R:R:W480	22.97	No	Yes	0	8	9
303	R:R:K510	R:R:S483	4.59	No	No	0	4	7
304	R:R:N511	R:R:S483	10.43	No	No	0	4	7
305	L:L:?1	R:R:F484	13.02	Yes	Yes	0	0	6
306	R:R:L489	R:R:R485	7.29	No	No	8	4	5
307	R:R:Q491	R:R:Y487	4.51	No	No	0	4	4
308	R:R:I509	R:R:Y487	10.88	No	No	0	4	4
309	R:R:C490	R:R:C507	7.28	No	No	0	9	9
310	R:R:C507	R:R:E508	4.56	No	No	0	9	4
311	L:L:?1	R:R:P513	11.7	Yes	No	0	0	8
312	R:R:S514	R:R:V517	6.46	No	No	1	7	6
313	R:R:I520	R:R:L516	4.28	No	No	0	5	4
314	L:L:?1	R:R:E518	25.62	Yes	No	0	0	7
315	L:L:?1	R:R:N521	5.59	Yes	Yes	0	0	8
316	R:R:F526	R:R:L522	7.31	Yes	No	1	9	7
317	L:L:?1	R:R:L522	5.63	Yes	No	1	0	7
318	R:R:F526	R:R:M525	8.71	Yes	No	0	9	5
319	R:R:T534	R:R:W537	16.98	No	No	0	7	8
320	R:R:T541	R:R:V536	6.35	No	Yes	10	8	8
321	R:R:T548	R:R:W545	6.06	No	Yes	0	6	9
322	R:R:R546	R:R:W549	4	No	No	0	5	5
323	S:S:G191	S:S:S190	3.71	No	No	0	5	6
324	S:S:R199	S:S:S190	7.91	Yes	No	0	4	6
325	S:S:C193	S:S:R199	4.18	No	Yes	0	9	4
326	S:S:C193	S:S:C213	7.28	No	No	0	9	9
327	S:S:P196	S:S:Q216	6.32	Yes	No	0	7	7
328	S:S:P196	S:S:P220	7.79	Yes	No	0	7	8
329	S:S:P196	S:S:Y487	4.17	Yes	No	13	7	4
330	S:S:P196	S:S:V488	5.3	Yes	No	0	7	6
331	S:S:P196	S:S:Q491	4.74	Yes	No	13	7	4
332	S:S:L197	S:S:V210	4.47	No	No	0	9	5
333	S:S:C213	S:S:L197	4.76	No	No	0	9	9
334	S:S:D201	S:S:R199	7.15	No	Yes	0	5	4
335	S:S:G212	S:S:R199	4.5	No	Yes	0	7	4
336	S:S:S205	S:S:T200	4.8	Yes	No	7	7	6
337	S:S:D298	S:S:T200	11.56	Yes	No	7	7	6
338	S:S:N202	S:S:P203	4.89	Yes	No	0	5	4
339	S:S:K204	S:S:N202	5.6	No	Yes	7	3	5
340	S:S:N202	S:S:S205	10.43	Yes	Yes	7	5	7
341	S:S:N202	S:S:R296	6.03	Yes	Yes	7	5	6
342	S:S:D298	S:S:N202	5.39	Yes	Yes	7	7	5
343	S:S:P203	S:S:W206	12.16	No	No	0	4	4
344	S:S:K204	S:S:R296	3.71	No	Yes	7	3	6
345	S:S:K204	S:S:S308	6.12	No	No	0	3	8
346	S:S:R296	S:S:S205	9.22	Yes	Yes	7	6	7
347	S:S:D298	S:S:S205	8.83	Yes	Yes	7	7	7
348	S:S:S205	S:S:T300	6.4	Yes	Yes	7	7	7
349	S:S:E211	S:S:W206	5.45	No	No	0	5	4
350	S:S:G212	S:S:W206	8.44	No	No	0	7	4
351	S:S:E208	S:S:Y207	13.47	No	No	0	4	7
352	S:S:V488	S:S:Y207	8.83	No	No	0	6	7
353	S:S:E208	S:S:R485	12.79	No	No	0	4	5
354	S:S:I215	S:S:M301	5.83	No	No	0	5	4
355	S:S:F484	S:S:I215	5.02	Yes	No	0	6	5
356	S:S:C217	S:S:C295	7.28	No	No	2	9	9
357	S:S:E224	S:S:Q218	5.1	No	No	0	4	5
358	S:S:H227	S:S:Q218	17.31	Yes	No	2	7	5
359	S:S:Q218	S:S:S385	4.33	No	No	2	5	7
360	S:S:N219	S:S:P220	4.89	Yes	No	0	7	8
361	S:S:L221	S:S:N219	4.12	No	Yes	0	6	7
362	S:S:F222	S:S:N219	8.46	Yes	Yes	2	6	7
363	S:S:D384	S:S:N219	5.39	Yes	Yes	2	8	7
364	S:S:N219	S:S:V386	4.43	Yes	Yes	2	7	5
365	M:M:?1	S:S:N219	6.99	Yes	Yes	2	0	7
366	S:S:F484	S:S:P220	7.22	Yes	No	0	6	8
367	S:S:F484	S:S:L221	8.53	Yes	No	0	6	6
368	S:S:I509	S:S:L221	4.28	No	No	0	4	6
369	S:S:E226	S:S:F222	5.83	No	Yes	2	8	6
370	S:S:F222	S:S:V386	5.24	Yes	Yes	2	6	5
371	S:S:F222	S:S:R512	10.69	Yes	No	2	6	6
372	S:S:F222	S:S:P513	7.22	Yes	No	0	6	8
373	S:S:F222	S:S:L515	12.18	Yes	No	0	6	5
374	S:S:E226	S:S:T223	12.7	No	No	0	8	5
375	S:S:E224	S:S:Q228	6.37	No	No	0	4	3
376	S:S:E226	S:S:R512	10.47	No	No	2	8	6
377	S:S:H227	S:S:H231	4.78	Yes	No	2	7	7
378	S:S:H227	S:S:S385	6.97	Yes	No	2	7	7
379	S:S:H227	S:S:V386	9.69	Yes	Yes	2	7	5
380	S:S:D229	S:S:K519	6.91	No	No	0	6	7
381	S:S:I234	S:S:M230	4.37	Yes	No	0	7	7
382	S:S:L515	S:S:M230	5.65	No	No	0	5	7
383	S:S:K519	S:S:M230	5.76	No	No	0	7	7
384	S:S:H231	S:S:Q284	3.71	No	Yes	2	7	9
385	S:S:H231	S:S:R290	28.21	No	No	2	7	9
386	S:S:F237	S:S:Y233	10.32	No	No	0	4	6
387	S:S:K519	S:S:Y233	23.89	No	No	0	7	6
388	S:S:I234	S:S:W281	5.87	Yes	Yes	2	7	7
389	S:S:I234	S:S:Q284	4.12	Yes	Yes	2	7	9
390	S:S:F285	S:S:I234	5.02	No	Yes	2	8	7
391	S:S:A235	S:S:F285	5.55	No	No	0	5	8
392	S:S:F237	S:S:F523	5.36	No	No	0	4	6
393	S:S:F237	S:S:F526	10.72	No	Yes	0	4	9
394	S:S:G238	S:S:L282	5.13	No	No	0	7	7
395	S:S:F526	S:S:G238	6.02	Yes	No	0	9	7
396	S:S:F526	S:S:T241	11.67	Yes	No	0	9	7
397	S:S:I530	S:S:T241	7.6	No	No	0	7	7
398	S:S:G242	S:S:S278	3.71	No	No	0	4	8
399	S:S:C244	S:S:S533	5.16	No	No	0	6	9
400	S:S:N271	S:S:T245	4.39	No	No	0	9	8
401	S:S:F275	S:S:T245	5.19	Yes	No	0	5	8
402	S:S:F275	S:S:L246	9.74	Yes	No	0	5	6
403	S:S:F247	S:S:T251	7.78	No	No	14	8	9
404	S:S:F247	S:S:W545	11.02	No	Yes	14	8	9
405	S:S:N271	S:S:T248	13.16	No	No	0	9	8
406	S:S:S533	S:S:T248	4.8	No	No	0	9	8
407	S:S:T248	S:S:V536	11.11	No	No	0	8	8
408	S:S:F275	S:S:L249	4.87	Yes	No	0	5	6
409	S:S:T251	S:S:V536	9.52	No	No	0	9	8
410	S:S:T251	S:S:W545	12.13	No	Yes	14	9	9
411	S:S:F252	S:S:S259	6.61	No	No	0	9	8
412	S:S:F252	S:S:F268	16.08	No	Yes	0	9	8
413	S:S:F252	S:S:W535	4.01	No	Yes	0	9	9
414	S:S:D255	S:S:N258	8.08	Yes	No	0	8	8
415	S:S:D255	S:S:S259	8.83	Yes	No	0	8	8
416	S:S:D255	S:S:I544	11.2	Yes	No	0	8	6
417	S:S:N260	S:S:W256	20.34	No	No	0	7	7
418	S:S:N260	S:S:V265	7.39	No	Yes	0	7	8
419	S:S:N260	S:S:T357	4.39	No	No	0	7	6
420	S:S:V265	S:S:Y262	8.83	Yes	Yes	0	8	9
421	S:S:I266	S:S:Y262	4.84	Yes	Yes	0	8	9
422	S:S:T357	S:S:Y262	6.24	No	Yes	0	6	9
423	S:S:F360	S:S:Y262	7.22	No	Yes	0	9	9
424	S:S:L452	S:S:P263	6.57	No	No	0	8	9
425	S:S:A264	S:S:W535	3.89	No	Yes	0	9	9
426	S:S:F268	S:S:V265	3.93	Yes	Yes	5	8	8
427	S:S:V265	S:S:Y269	5.05	Yes	Yes	5	8	8
428	S:S:I266	S:S:W331	4.7	Yes	Yes	5	8	9
429	S:S:I266	S:S:V334	6.14	Yes	No	5	8	7
430	S:S:I266	S:S:L335	5.71	Yes	No	0	8	8
431	S:S:L267	S:S:L335	5.54	No	No	0	8	8
432	S:S:L267	S:S:W535	28.47	No	Yes	0	8	9
433	S:S:F268	S:S:Y269	12.38	Yes	Yes	5	8	8
434	S:S:W331	S:S:Y269	18.33	Yes	Yes	5	9	8
435	S:S:H361	S:S:Y269	10.89	No	Yes	5	9	8
436	S:S:W365	S:S:Y269	4.82	Yes	Yes	5	9	8
437	S:S:M532	S:S:V270	4.56	No	No	0	8	8
438	S:S:C273	S:S:G328	3.92	No	No	0	9	8
439	S:S:F274	S:S:M525	3.73	No	No	0	9	5
440	S:S:F274	S:S:T528	9.08	No	No	0	9	7
441	S:S:F274	S:S:G529	9.03	No	No	0	9	9
442	S:S:F275	S:S:I279	6.28	Yes	No	0	5	5
443	S:S:V321	S:S:W281	7.36	No	Yes	2	8	7
444	S:S:I389	S:S:W281	11.74	Yes	Yes	2	9	7
445	S:S:L522	S:S:W281	4.56	No	Yes	2	7	7
446	S:S:M525	S:S:W281	4.65	No	Yes	2	5	7
447	S:S:F526	S:S:W281	10.02	Yes	Yes	2	9	7
448	M:M:?1	S:S:W281	8.69	Yes	Yes	2	0	7
449	S:S:F285	S:S:Q284	16.4	No	Yes	2	8	9
450	S:S:Q284	S:S:R290	17.52	Yes	No	2	9	9
451	S:S:G388	S:S:Q284	8.22	No	Yes	2	9	9
452	S:S:G388	S:S:R290	4.5	No	No	2	9	9
453	S:S:C295	S:S:R291	4.18	No	No	0	9	5
454	S:S:E292	S:S:T311	12.7	No	No	0	5	7
455	S:S:E292	S:S:S313	8.62	No	No	0	5	7
456	S:S:I293	S:S:I317	8.83	No	No	0	8	7
457	S:S:D298	S:S:R296	5.96	Yes	Yes	7	7	6
458	S:S:R296	S:S:T300	5.17	Yes	Yes	7	6	7
459	S:S:E310	S:S:R296	20.93	No	Yes	0	8	6
460	S:S:D298	S:S:T300	11.56	Yes	Yes	7	7	7
461	S:S:L303	S:S:M301	7.07	No	No	0	3	4
462	S:S:E305	S:S:R302	16.28	No	Yes	17	7	6
463	S:S:E310	S:S:R302	5.82	No	Yes	0	8	6
464	S:S:R302	S:S:T311	6.47	Yes	No	0	6	7
465	S:S:C314	S:S:R302	11.14	No	Yes	17	9	6
466	S:S:D382	S:S:L303	5.43	No	No	16	9	3
467	S:S:K395	S:S:L303	4.23	No	No	16	3	3
468	S:S:E305	S:S:T307	5.64	No	No	0	7	6
469	S:S:C314	S:S:E305	10.64	No	No	17	9	7
470	S:S:P306	S:S:V315	5.3	No	No	0	5	7
471	S:S:L376	S:S:P306	6.57	No	No	0	8	5
472	S:S:C314	S:S:C390	7.28	No	No	0	9	9
473	S:S:F318	S:S:Y322	9.28	Yes	Yes	1	9	9
474	S:S:F318	S:S:I375	10.05	Yes	Yes	1	9	7
475	S:S:F318	S:S:V381	15.73	Yes	No	0	9	8
476	S:S:I389	S:S:V321	6.14	Yes	No	2	9	8
477	S:S:M326	S:S:Y322	13.17	No	Yes	0	8	9
478	S:S:L371	S:S:Y322	5.86	No	Yes	0	8	9
479	S:S:T372	S:S:Y322	6.24	No	Yes	0	9	9
480	S:S:I375	S:S:Y322	8.46	Yes	Yes	1	7	9
481	S:S:F403	S:S:Y322	5.16	Yes	Yes	1	8	9
482	S:S:W365	S:S:Y323	6.75	Yes	Yes	0	9	8
483	S:S:P368	S:S:Y323	6.95	No	Yes	0	9	8
484	S:S:T372	S:S:Y323	4.99	No	Yes	0	9	8
485	S:S:A327	S:S:P368	3.74	No	No	0	9	9
486	S:S:V329	S:S:V411	9.62	No	No	0	6	5
487	S:S:V334	S:S:W331	4.9	No	Yes	5	7	9
488	S:S:T364	S:S:W331	21.83	No	Yes	5	9	9
489	S:S:W331	S:S:W365	14.99	Yes	Yes	5	9	9
490	S:S:F332	S:S:T336	5.19	No	Yes	0	9	7
491	S:S:F332	S:S:F460	4.29	No	Yes	0	9	5
492	S:S:F360	S:S:V334	6.55	No	No	0	9	7
493	S:S:G415	S:S:T336	5.46	No	Yes	0	8	7
494	S:S:F418	S:S:T336	5.19	Yes	Yes	0	8	7
495	S:S:L419	S:S:T336	5.9	No	Yes	0	7	7
496	S:S:T341	S:S:Y337	9.99	No	No	0	6	7
497	S:S:F418	S:S:Y337	10.32	Yes	No	0	8	7
498	S:S:F343	S:S:W339	7.02	Yes	Yes	0	9	9
499	S:S:G422	S:S:W339	4.22	No	Yes	0	8	9
500	S:S:L452	S:S:W339	6.83	No	Yes	0	8	9
501	S:S:G453	S:S:W339	8.44	No	Yes	0	5	9
502	S:S:F457	S:S:W339	4.01	No	Yes	0	4	9
503	S:S:H340	S:S:T341	4.11	No	No	9	7	6
504	S:S:H340	S:S:K344	6.55	No	No	9	7	6
505	S:S:F418	S:S:H340	10.18	Yes	No	9	8	7
506	S:S:K344	S:S:T341	6.01	No	No	9	6	6
507	S:S:F343	S:S:S342	5.28	Yes	No	18	9	8
508	S:S:M449	S:S:S342	9.2	Yes	No	18	9	8
509	S:S:F343	S:S:T425	5.19	Yes	No	0	9	7
510	S:S:F343	S:S:L426	8.53	Yes	No	0	9	9
511	S:S:F343	S:S:M449	3.73	Yes	Yes	18	9	9
512	S:S:I445	S:S:L346	19.98	No	No	0	9	6
513	S:S:H361	S:S:W365	9.52	No	Yes	5	9	9
514	S:S:T364	S:S:W365	7.28	No	Yes	5	9	9
515	S:S:F369	S:S:V373	3.93	No	No	0	7	7
516	S:S:I375	S:S:V392	12.29	Yes	No	1	7	9
517	S:S:F403	S:S:I375	15.07	Yes	Yes	1	8	7
518	S:S:N396	S:S:Q380	6.6	No	No	0	7	7
519	S:S:Q380	S:S:Y399	24.8	No	No	0	7	5
520	S:S:D382	S:S:K395	4.15	No	No	16	9	3
521	S:S:D384	S:S:V386	7.3	Yes	Yes	2	8	5
522	S:S:D384	S:S:S387	7.36	Yes	Yes	2	8	8
523	S:S:D384	S:S:Y394	9.2	Yes	Yes	2	8	5
524	M:M:?1	S:S:D384	7.6	Yes	Yes	2	0	8
525	S:S:I389	S:S:S387	4.64	Yes	Yes	2	9	8
526	S:S:S387	S:S:Y394	6.36	Yes	Yes	2	8	5
527	M:M:?1	S:S:S387	4.58	Yes	Yes	2	0	8
528	S:S:F391	S:S:I389	3.77	Yes	Yes	2	8	9
529	S:S:F391	S:S:Y394	9.28	Yes	Yes	2	8	5
530	S:S:F391	S:S:V404	3.93	Yes	No	0	8	7
531	M:M:?1	S:S:F391	5.58	Yes	Yes	2	0	8
532	S:S:F403	S:S:V392	3.93	Yes	No	1	8	9
533	M:M:?1	S:S:Y394	11.93	Yes	Yes	2	0	5
534	S:S:K395	S:S:N396	8.39	No	No	0	3	7
535	S:S:R398	S:S:Y397	13.38	No	Yes	0	1	3
536	S:S:F474	S:S:Y397	4.13	Yes	Yes	2	6	3
537	S:S:Q477	S:S:Y397	6.76	Yes	Yes	2	6	3
538	S:S:A478	S:S:Y397	5.34	No	Yes	0	3	3
539	S:S:E481	S:S:Y397	7.86	No	Yes	2	5	3
540	S:S:H470	S:S:R400	11.28	No	No	0	7	9
541	S:S:D473	S:S:R400	10.72	No	No	0	8	9
542	M:M:?1	S:S:R400	8.65	Yes	No	0	0	9
543	S:S:A401	S:S:F474	4.16	No	Yes	0	6	6
544	S:S:H470	S:S:V404	6.92	No	No	0	7	7
545	S:S:F467	S:S:L405	8.53	Yes	No	0	7	8
546	S:S:F471	S:S:L405	7.31	No	No	2	4	8
547	S:S:F474	S:S:L405	4.87	Yes	No	2	6	8
548	S:S:F467	S:S:I408	5.02	Yes	No	0	7	7
549	S:S:F467	S:S:G409	4.52	Yes	No	0	7	4
550	S:S:L410	S:S:V414	4.47	Yes	No	0	4	5
551	S:S:F460	S:S:L412	6.09	Yes	Yes	0	5	7
552	S:S:L412	S:S:V463	4.47	Yes	No	0	7	7
553	S:S:L412	S:S:L464	4.15	Yes	No	0	7	4
554	S:S:F467	S:S:L412	4.87	Yes	Yes	0	7	7
555	S:S:F418	S:S:V414	3.93	Yes	No	9	8	5
556	S:S:F460	S:S:G416	4.52	Yes	No	0	5	5
557	S:S:F418	S:S:Y417	6.19	Yes	No	0	8	5
558	S:S:R421	S:S:Y417	15.43	No	No	0	7	5
559	S:S:F457	S:S:L419	19.49	No	No	0	4	7
560	S:S:K430	S:S:L426	4.23	No	No	0	8	9
561	S:S:K430	S:S:L437	4.23	No	No	0	8	6
562	S:S:H433	S:S:N432	20.41	No	No	0	8	6
563	S:S:H433	S:S:L436	5.14	No	No	0	8	6
564	S:S:G435	S:S:S438	3.71	No	No	0	5	8
565	S:S:A442	S:S:I445	4.87	No	No	0	8	9
566	S:S:K444	S:S:T448	6.01	No	No	0	9	8
567	S:S:I445	S:S:M449	5.83	No	Yes	0	9	9
568	S:S:F455	S:S:R451	9.62	Yes	No	15	8	9
569	S:S:R451	S:S:W535	9	No	Yes	15	9	9
570	S:S:R451	S:S:T538	5.17	No	No	0	9	8
571	S:S:F455	S:S:I454	3.77	Yes	No	0	8	6
572	S:S:F455	S:S:M532	3.73	Yes	No	0	8	8
573	S:S:F455	S:S:W535	12.03	Yes	Yes	15	8	9
574	S:S:F462	S:S:L458	4.87	No	No	0	7	6
575	S:S:F462	S:S:T528	5.19	No	No	0	7	7
576	S:S:A524	S:S:I465	4.87	No	No	0	7	5
577	S:S:N521	S:S:T466	5.85	Yes	No	0	8	8
578	S:S:C469	S:S:N521	6.3	No	Yes	0	7	8
579	S:S:H470	S:S:N521	14.03	No	Yes	0	7	8
580	S:S:F471	S:S:F474	5.36	No	Yes	2	4	6
581	S:S:N476	S:S:Y472	12.79	No	No	2	6	7
582	S:S:W480	S:S:Y472	5.79	Yes	No	2	9	7
583	S:S:V517	S:S:Y472	10.09	No	No	0	6	7
584	S:S:D473	S:S:W480	5.58	No	Yes	0	8	9
585	S:S:D473	S:S:E518	11.69	No	No	0	8	7
586	S:S:N476	S:S:W480	10.17	No	Yes	2	6	9
587	S:S:Q477	S:S:W480	5.48	Yes	Yes	2	6	9
588	S:S:E481	S:S:Q477	7.65	No	Yes	2	5	6
589	M:M:?1	S:S:Q477	7.45	Yes	Yes	2	0	6
590	S:S:E479	S:S:R482	8.14	No	No	0	2	3
591	S:S:E479	S:S:N511	14.46	No	Yes	0	2	4
592	S:S:N511	S:S:W480	6.78	Yes	Yes	2	4	9
593	S:S:P513	S:S:W480	17.57	No	Yes	0	8	9
594	S:S:K510	S:S:S483	6.12	No	No	2	4	7
595	S:S:N511	S:S:S483	8.94	Yes	No	2	4	7
596	S:S:F484	S:S:V488	3.93	Yes	No	0	6	6
597	M:M:?1	S:S:F484	18.59	Yes	Yes	0	0	6
598	S:S:L489	S:S:R485	8.5	No	No	0	4	5
599	S:S:Q491	S:S:Y487	11.27	No	No	13	4	4
600	S:S:I509	S:S:Y487	10.88	No	No	0	4	4
601	S:S:C490	S:S:C507	5.46	No	No	0	9	9
602	S:S:C507	S:S:Q491	7.63	No	No	0	9	4
603	S:S:D506	S:S:E508	3.9	No	No	0	3	4
604	S:S:K510	S:S:N511	5.6	No	Yes	2	4	4
605	M:M:?1	S:S:P513	12.53	Yes	No	0	0	8
606	S:S:S514	S:S:V517	6.46	No	No	0	7	6
607	S:S:I520	S:S:L516	4.28	No	No	0	5	4
608	M:M:?1	S:S:E518	28.32	Yes	No	0	0	7
609	M:M:?1	S:S:N521	4.89	Yes	Yes	0	0	8
610	S:S:F526	S:S:L522	4.87	Yes	No	2	9	7
611	M:M:?1	S:S:L522	5.63	Yes	No	2	0	7
612	S:S:F526	S:S:M525	11.2	Yes	No	2	9	5
613	S:S:S533	S:S:W537	3.71	No	No	0	9	8
614	S:S:T534	S:S:W537	13.34	No	No	0	7	8
615	S:S:T541	S:S:V536	4.76	No	No	0	8	8
616	S:S:T538	S:S:T541	4.71	No	No	0	8	8
617	S:S:T548	S:S:W545	4.85	No	Yes	0	6	9
618	S:S:R547	S:S:R551	12.79	No	No	0	6	7
619	S:S:C550	S:S:R551	5.57	No	No	0	4	7
620	R:R:V423	R:R:W339	3.68	No	Yes	0	7	9
621	S:S:V423	S:S:W339	3.68	No	Yes	0	7	9
622	R:R:F275	R:R:L249	3.65	Yes	No	0	5	6
623	R:R:F318	R:R:L376	3.65	Yes	No	0	9	8
624	S:S:F318	S:S:L376	3.65	Yes	No	0	9	8
625	S:S:K356	S:S:Y262	3.58	No	Yes	0	8	9
626	S:S:D255	S:S:R547	3.57	Yes	No	0	8	6
627	R:R:P196	R:R:V488	3.53	Yes	No	0	7	6
628	R:R:G280	R:R:I320	3.53	No	No	0	7	5
629	R:R:P407	S:S:V370	3.53	No	No	0	9	5
630	R:R:G527	R:R:I530	3.53	No	No	0	5	7
631	S:S:G280	S:S:I320	3.53	No	No	0	7	5
632	S:S:P368	S:S:V330	3.53	No	No	0	9	6
633	S:S:G527	S:S:I530	3.53	No	No	0	5	7
634	S:S:L197	S:S:Y207	3.52	No	No	0	9	7
635	S:S:P263	S:S:T448	3.5	No	No	0	9	8
636	R:R:C217	R:R:V294	3.42	No	No	0	9	8
637	R:R:G456	R:R:L335	3.42	No	No	0	7	8
638	R:R:A324	R:R:V276	3.39	No	No	0	7	5
639	S:S:A324	S:S:V276	3.39	No	No	0	7	5
640	S:S:M326	S:S:P407	3.35	No	No	0	8	9
641	R:R:C469	R:R:I520	3.27	No	No	0	7	5
642	S:S:C469	S:S:I520	3.27	No	No	0	7	5
643	R:R:A283	R:R:I317	3.25	No	No	0	5	7
644	R:R:A442	R:R:I445	3.25	No	No	0	8	9
645	R:R:A524	R:R:I465	3.25	No	No	0	7	5
646	S:S:A283	S:S:I317	3.25	No	No	0	5	7
647	R:R:A459	R:R:M532	3.22	No	Yes	0	7	8
648	S:S:A459	S:S:M532	3.22	No	No	0	7	8
649	R:R:V329	R:R:V463	3.21	No	No	0	6	7
650	R:R:V333	R:R:V411	3.21	No	No	0	9	5
651	S:S:V333	S:S:V411	3.21	No	No	0	9	5
652	R:R:S278	R:R:T241	3.2	No	No	0	8	7
653	S:S:S278	S:S:T241	3.2	No	No	0	8	7
654	R:R:G347	R:R:H433	3.18	No	Yes	0	7	8
655	R:R:T364	R:R:V330	3.17	No	No	0	9	6
656	S:S:T372	S:S:V319	3.17	No	No	0	9	7
657	S:S:T336	S:S:V333	3.17	Yes	No	0	7	9
658	R:R:A442	R:R:L436	3.15	No	No	0	8	6
659	R:R:A531	R:R:L458	3.15	No	No	0	6	6
660	S:S:A531	S:S:L458	3.15	No	No	0	6	6
661	R:R:R261	R:R:Y262	3.09	No	Yes	0	7	9
662	S:S:F369	S:S:Y323	3.09	No	Yes	0	7	8
663	R:R:I530	R:R:V240	3.07	No	No	0	7	4
664	R:R:I293	R:R:V294	3.07	No	No	0	8	8
665	R:R:I413	R:R:V414	3.07	No	No	0	3	5
666	S:S:I530	S:S:V240	3.07	No	No	0	7	4
667	R:R:K444	R:R:S443	3.06	No	No	0	9	6
668	R:R:C213	R:R:Q192	3.05	No	No	0	9	4
669	S:S:C193	S:S:Q192	3.05	No	No	0	9	4
670	R:R:M532	R:R:V270	3.04	Yes	No	0	8	8
671	S:S:A297	S:S:E310	3.02	No	No	0	5	8
672	R:R:F460	R:R:G416	3.01	Yes	No	0	5	5
673	R:R:F460	R:R:G461	3.01	Yes	No	0	5	5
674	S:S:F460	S:S:G461	3.01	Yes	No	0	5	5
675	R:R:S366	S:S:L410	3	No	Yes	0	7	4
676	S:S:L437	S:S:S438	3	No	No	0	6	8
677	R:R:L312	R:R:V315	2.98	No	No	0	7	7
678	R:R:Y359	S:S:Y337	2.98	No	No	0	7	7
679	R:R:L410	S:S:V370	2.98	No	No	0	4	5
680	R:R:N432	R:R:S428	2.98	No	No	0	6	5
681	S:S:N309	S:S:S308	2.98	No	No	0	6	8
682	S:S:L312	S:S:V315	2.98	No	No	0	7	7
683	S:S:I316	S:S:I320	2.94	No	No	0	5	5
684	S:S:I317	S:S:I389	2.94	No	Yes	0	7	9
685	R:R:Q216	R:R:V195	2.87	No	No	0	7	4
686	R:R:Q216	R:R:V198	2.87	No	No	0	7	6
687	S:S:Q216	S:S:V195	2.87	No	No	0	7	4
688	S:S:Q216	S:S:V198	2.87	No	No	0	7	6
689	R:R:E194	R:R:V195	2.85	No	No	0	6	4
690	R:R:I316	R:R:L312	2.85	No	No	0	5	7
691	R:R:I445	R:R:L346	2.85	No	No	0	9	6
692	S:S:E194	S:S:V195	2.85	No	No	0	6	4
693	S:S:I316	S:S:L312	2.85	No	No	0	5	7
694	S:S:I413	S:S:L410	2.85	No	Yes	0	3	4
695	S:S:I429	S:S:L426	2.85	No	No	0	7	9
696	R:R:L325	R:R:M326	2.83	No	No	0	5	8
697	R:R:L458	R:R:M532	2.83	No	Yes	0	6	8
698	S:S:L325	S:S:M326	2.83	No	No	0	5	8
699	R:R:K430	R:R:L426	2.82	No	No	0	8	9
700	R:R:L363	S:S:L363	2.77	No	No	0	4	4
701	R:R:F403	S:S:A374	2.77	Yes	No	1	8	5
702	R:R:A524	R:R:F462	2.77	No	No	0	7	7
703	R:R:D486	R:R:K510	2.77	No	No	0	4	4
704	S:S:A374	S:S:F403	2.77	No	Yes	1	5	8
705	S:S:A524	S:S:F462	2.77	No	No	0	7	7
706	R:R:L437	R:R:N446	2.75	No	No	0	6	7
707	S:S:E447	S:S:K444	2.7	No	No	0	6	9
708	R:R:F360	R:R:S358	2.64	Yes	No	0	9	6
709	R:R:F268	R:R:V253	2.62	Yes	No	0	8	5
710	S:S:F268	S:S:V253	2.62	Yes	No	0	8	5
711	R:R:C273	R:R:W365	2.61	No	Yes	0	9	9
712	S:S:C273	S:S:W365	2.61	No	Yes	0	9	9
713	R:R:A250	R:R:W545	2.59	No	Yes	0	6	9
714	R:R:A254	R:R:W545	2.59	No	Yes	0	8	9
715	R:R:A264	R:R:W535	2.59	No	Yes	0	9	9
716	S:S:A250	S:S:W545	2.59	No	Yes	0	6	9
717	R:R:H433	R:R:N432	2.55	Yes	No	0	8	6
718	S:S:N258	S:S:R257	2.41	No	No	0	8	5
719	S:S:C390	S:S:G383	1.96	No	No	0	9	8
720	R:R:A324	R:R:G277	1.95	No	No	0	7	6
721	R:R:A374	S:S:G402	1.95	No	No	0	5	5
722	R:R:A377	S:S:G402	1.95	No	No	0	8	5
723	R:R:A401	R:R:G402	1.95	No	No	0	6	5
724	R:R:A406	R:R:G402	1.95	No	No	0	5	5
725	R:R:G402	S:S:A377	1.95	No	No	0	5	8
726	S:S:A324	S:S:G277	1.95	No	No	0	7	6
727	S:S:A401	S:S:G402	1.95	No	No	0	6	5
728	R:R:A338	R:R:P263	1.87	No	No	0	8	9
729	R:R:A379	R:R:P306	1.87	No	No	0	6	5
730	S:S:A338	S:S:P263	1.87	No	No	0	8	9
731	S:S:A379	S:S:P306	1.87	No	No	0	6	5
732	S:S:A406	S:S:P407	1.87	No	No	0	5	9
733	R:R:G435	R:R:S438	1.86	No	Yes	0	5	8
734	R:R:G280	R:R:V321	1.84	No	No	0	7	8
735	R:R:G393	R:R:V392	1.84	No	Yes	0	9	9
736	S:S:G383	S:S:V294	1.84	No	Yes	0	8	8
737	S:S:G388	S:S:V294	1.84	No	Yes	2	9	8
738	S:S:G393	S:S:V392	1.84	No	No	0	9	9
739	R:R:G214	R:R:T200	1.82	No	No	0	8	6
740	R:R:G214	R:R:T300	1.82	No	Yes	0	8	7
741	R:R:G347	R:R:T348	1.82	No	No	0	7	7
742	S:S:G214	S:S:T200	1.82	No	No	0	8	6
743	S:S:G214	S:S:T300	1.82	No	Yes	0	8	7
744	R:R:P263	R:R:T448	1.75	No	No	0	9	8
745	R:R:G304	R:R:L303	1.71	No	No	0	5	3
746	R:R:A441	R:R:S438	1.71	No	Yes	0	8	8
747	S:S:C217	S:S:V294	1.71	No	Yes	2	9	8
748	S:S:C295	S:S:V294	1.71	No	Yes	2	9	8
749	S:S:G456	S:S:L335	1.71	No	No	0	7	8
750	S:S:G456	S:S:L419	1.71	No	No	0	7	7
751	R:R:A225	R:R:T223	1.68	No	No	0	4	5
752	R:R:D298	R:R:G299	1.68	Yes	No	0	7	4
753	R:R:A540	R:R:T538	1.68	No	No	0	8	8
754	S:S:A225	S:S:T223	1.68	No	No	0	4	5
755	S:S:A254	S:S:T548	1.68	No	No	0	8	6
756	S:S:D298	S:S:G299	1.68	Yes	No	0	7	4
757	S:S:D382	S:S:G304	1.68	No	No	0	9	5
758	S:S:A540	S:S:T538	1.68	No	No	0	8	8
759	R:R:L367	R:R:P368	1.64	No	No	0	5	9
760	R:R:A289	R:R:I293	1.62	No	No	0	7	8
761	S:S:A289	S:S:I293	1.62	No	No	0	7	8
762	R:R:A289	R:R:M286	1.61	No	No	0	7	4
763	S:S:A289	S:S:M286	1.61	No	No	0	7	4
764	R:R:A272	R:R:L249	1.58	No	No	0	4	6
765	S:S:A272	S:S:L249	1.58	No	No	0	4	6
766	R:R:T348	R:R:T349	1.57	No	No	0	7	6
767	S:S:A492	S:S:N493	1.56	No	No	0	5	5
768	R:R:I320	R:R:V276	1.54	No	No	0	5	5
769	S:S:I320	S:S:V276	1.54	No	No	0	5	5
770	R:R:K440	R:R:S438	1.53	No	Yes	0	6	8
771	R:R:A297	R:R:E310	1.51	No	Yes	0	5	8
772	R:R:L367	S:S:S366	1.5	No	No	0	5	7
773	R:R:L464	R:R:S468	1.5	No	No	0	4	4
774	S:S:L362	S:S:S366	1.5	No	No	0	5	7
775	R:R:I420	R:R:M424	1.46	No	No	0	5	5
776	S:S:I420	S:S:M424	1.46	No	No	0	5	5
777	S:S:I429	S:S:L436	1.43	No	No	0	7	6
778	S:S:I454	S:S:L450	1.43	No	No	0	6	6
779	S:S:K539	S:S:L542	1.41	No	No	0	5	4
780	S:S:M449	S:S:N446	1.4	Yes	No	0	9	7
781	R:R:C295	R:R:R291	1.39	No	No	0	9	5
782	R:R:L363	R:R:L367	1.38	No	No	0	4	5
783	R:R:E447	R:R:L450	1.33	No	No	0	6	6
784	S:S:F427	S:S:S431	1.32	No	No	0	7	5
785	S:S:D209	S:S:E208	1.3	No	No	0	4	4
786	S:S:M424	S:S:R421	1.24	No	No	0	5	7
787	S:S:N258	S:S:R261	1.21	No	No	0	8	7
788	S:S:F475	S:S:N476	1.21	No	No	0	3	6
789	S:S:D486	S:S:R482	1.19	No	No	0	4	3
790	S:S:D486	S:S:R485	1.19	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P196	6.1475	4	0	7
2	R:R:L197	4.5975	4	8	9
3	R:R:N202	6.5275	4	3	5
4	R:R:S205	8.07	5	3	7
5	R:R:Y207	7.4975	4	8	7
6	R:R:N219	6.09667	6	1	7
7	R:R:L221	4.8775	4	1	6
8	R:R:F222	8.62429	7	1	6
9	R:R:H227	11.2125	4	1	7
10	R:R:M230	5.03	4	0	7
11	R:R:T251	9.11	4	10	9
12	R:R:Y262	5.666	5	0	9
13	R:R:F268	8.788	5	0	8
14	R:R:Y269	9.012	5	6	8
15	R:R:F275	5.6075	4	0	5
16	R:R:W281	8.10167	6	1	7
17	R:R:Q284	11.755	4	1	9
18	R:R:R296	6.39333	6	3	6
19	R:R:D298	7.98667	6	3	7
20	R:R:T300	7.075	4	3	7
21	R:R:R302	8.4375	4	3	6
22	R:R:E310	5.215	4	3	8
23	R:R:F318	8.528	5	1	9
24	R:R:Y322	8.22333	6	1	9
25	R:R:W331	11.5	7	6	9
26	R:R:T336	5.8025	4	0	7
27	R:R:Y337	7.7825	4	4	7
28	R:R:W339	6.968	5	0	9
29	R:R:H340	7.46833	6	4	7
30	R:R:K344	6.65	4	4	6
31	R:R:Y350	6.722	5	4	7
32	R:R:F360	5.7625	4	6	9
33	R:R:W365	7.865	6	6	9
34	R:R:I375	11.4675	4	1	7
35	R:R:D384	7.662	5	1	8
36	R:R:V386	7.03	4	1	5
37	R:R:F391	5.23	5	1	8
38	R:R:V392	5.446	5	1	9
39	R:R:Y394	8.298	5	1	5
40	R:R:Y397	8.3075	4	1	3
41	R:R:F403	6.934	5	1	8
42	R:R:L412	4.59	4	0	7
43	R:R:F418	6.80833	6	4	8
44	R:R:R421	10.1225	4	4	7
45	R:R:H433	4.705	4	0	8
46	R:R:S438	2.3525	4	0	8
47	R:R:F455	8.1	4	11	8
48	R:R:F460	3.795	4	0	5
49	R:R:F467	5.735	4	0	7
50	R:R:Y472	9.07	4	1	7
51	R:R:Q477	8.13	4	1	6
52	R:R:W480	9.46167	6	1	9
53	R:R:F484	7.5325	4	0	6
54	R:R:N521	7.5775	4	0	8
55	R:R:F526	8.09833	6	1	9
56	R:R:M532	4.408	5	0	8
57	R:R:W535	9.848	5	11	9
58	R:R:V536	8.125	4	10	8
59	R:R:W545	5.39	5	10	9
60	S:S:P196	5.664	5	13	7
61	S:S:R199	5.935	4	0	4
62	S:S:N202	6.468	5	7	5
63	S:S:S205	7.936	5	7	7
64	S:S:N219	5.71333	6	2	7
65	S:S:F222	8.27	6	2	6
66	S:S:H227	9.6875	4	2	7
67	S:S:I234	4.845	4	2	7
68	S:S:D255	7.92	4	0	8
69	S:S:Y262	6.142	5	0	9
70	S:S:V265	6.3	4	5	8
71	S:S:I266	5.3475	4	5	8
72	S:S:F268	8.7525	4	5	8
73	S:S:Y269	10.294	5	5	8
74	S:S:F275	6.52	4	0	5
75	S:S:W281	7.55571	7	2	7
76	S:S:Q284	9.994	5	2	9
77	S:S:V294	1.775	4	2	8
78	S:S:R296	8.50333	6	7	6
79	S:S:D298	7.49667	6	7	7
80	S:S:T300	6.2375	4	7	7
81	S:S:R302	9.9275	4	17	6
82	S:S:F318	9.6775	4	1	9
83	S:S:Y322	8.02833	6	1	9
84	S:S:Y323	5.445	4	0	8
85	S:S:W331	12.95	5	5	9
86	S:S:T336	4.982	5	0	7
87	S:S:W339	5.7	6	0	9
88	S:S:F343	5.95	5	18	9
89	S:S:Y359	6.28	6	4	7
90	S:S:W365	7.66167	6	5	9
91	S:S:I375	11.4675	4	1	7
92	S:S:D384	7.37	5	2	8
93	S:S:V386	6.665	4	2	5
94	S:S:S387	5.735	4	2	8
95	S:S:I389	5.846	5	2	9
96	S:S:F391	5.64	4	2	8
97	S:S:Y394	9.1925	4	2	5
98	S:S:Y397	7.494	5	2	3
99	S:S:F403	6.25333	6	1	8
100	S:S:L410	3.7975	4	0	4
101	S:S:L412	4.895	4	0	7
102	S:S:F418	6.98333	6	9	8
103	S:S:M449	5.04	4	18	9
104	S:S:F455	7.2875	4	15	8
105	S:S:F460	4.4775	4	0	5
106	S:S:F467	5.735	4	0	7
107	S:S:F474	4.63	4	2	6
108	S:S:Q477	6.835	4	2	6
109	S:S:W480	8.56167	6	2	9
110	S:S:F484	8.658	5	0	6
111	S:S:N511	8.945	4	2	4
112	S:S:N521	7.7675	4	0	8
113	S:S:F526	9.08333	6	2	9
114	S:S:W535	11.48	5	15	9
115	S:S:W545	7.6475	4	14	9
116	L:L:?1	8.662	15	1	0
117	M:M:?1	10.11	13	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C213	R:R:Q192	64.096	3.05	No	No	0	9	4
2	R:R:P196	R:R:V488	68.9391	3.53	Yes	No	0	7	6
3	R:R:L197	R:R:V488	65.9023	4.47	Yes	No	8	9	6
4	R:R:C213	R:R:L197	65.068	4.76	No	Yes	0	9	9
5	R:R:P196	R:R:P220	72.2145	7.79	Yes	No	0	7	8
6	R:R:Q192	R:R:R199	63.6094	15.19	No	No	0	4	4
7	R:R:G212	R:R:R199	62.6349	4.5	No	No	0	7	4
8	R:R:G212	R:R:W206	62.147	8.44	No	No	0	7	4
9	R:R:P203	R:R:W206	61.1699	12.16	No	No	0	4	4
10	R:R:N202	R:R:P203	60.6808	4.89	Yes	No	0	5	4
11	R:R:N202	R:R:S205	20.5785	8.94	Yes	Yes	3	5	7
12	R:R:D298	R:R:N202	21.0931	8.08	Yes	Yes	3	7	5
13	R:R:K204	R:R:N202	18.5213	4.2	No	Yes	0	3	5
14	R:R:K204	R:R:R296	18.0146	6.19	No	Yes	0	3	6
15	R:R:R296	R:R:S205	18.0209	6.59	Yes	Yes	3	6	7
16	R:R:D298	R:R:R296	18.0285	4.76	Yes	Yes	3	7	6
17	R:R:F484	R:R:P220	35.904	7.22	Yes	No	0	6	8
18	R:R:C217	R:R:V294	12.3763	3.42	No	No	0	9	8
19	R:R:G383	R:R:V294	30.9283	5.52	No	No	0	8	8
20	R:R:C390	R:R:G383	34.0189	3.92	No	No	0	9	8
21	R:R:C314	R:R:C390	37.109	7.28	No	No	0	9	9
22	R:R:C314	R:R:R302	20.1047	11.14	No	Yes	3	9	6
23	R:R:E310	R:R:R302	26.2778	4.65	Yes	Yes	3	8	6
24	R:R:E310	R:R:R296	29.3599	10.47	Yes	Yes	3	8	6
25	R:R:C314	R:R:E305	20.0937	10.64	No	No	3	9	7
26	R:R:E305	R:R:T307	21.6377	11.29	No	No	3	7	6
27	R:R:R296	R:R:T307	23.1788	6.47	Yes	No	3	6	6
28	R:R:N219	R:R:P220	36.8005	6.52	Yes	No	0	7	8
29	L:L:?1	R:R:N219	40.0911	6.29	Yes	Yes	1	0	7
30	L:L:?1	R:R:F484	37.4307	13.02	Yes	Yes	0	0	6
31	R:R:F268	R:R:Y269	12.6805	9.28	Yes	Yes	0	8	8
32	R:R:W365	R:R:Y269	16.3466	3.86	Yes	Yes	6	9	8
33	R:R:W365	R:R:Y323	25.924	7.72	Yes	No	0	9	8
34	R:R:T372	R:R:Y323	68.2745	3.75	No	No	0	9	8
35	R:R:T372	R:R:Y322	68.9762	6.24	No	Yes	0	9	9
36	R:R:F318	R:R:Y322	20.199	9.28	Yes	Yes	1	9	9
37	R:R:F318	R:R:V392	20.6594	3.93	Yes	Yes	1	9	9
38	R:R:F391	R:R:V392	100	3.93	Yes	Yes	1	8	9
39	L:L:?1	R:R:F391	90.799	4.96	Yes	Yes	1	0	8
40	R:R:I375	R:R:Y322	19.1772	8.46	Yes	Yes	1	7	9
41	R:R:I375	R:R:V392	19.235	12.29	Yes	Yes	1	7	9
42	R:R:F403	R:R:Y322	33.5122	5.16	Yes	Yes	1	8	9
43	R:R:F403	R:R:V392	61.8054	5.24	Yes	Yes	1	8	9
44	R:R:L452	R:R:W339	17.2014	5.69	No	Yes	0	8	9
45	R:R:F457	R:R:W339	27.1557	6.01	No	Yes	0	4	9
46	R:R:F457	R:R:L419	27.6033	19.49	No	No	0	4	7
47	R:R:L419	R:R:T336	28.0505	7.37	No	Yes	0	7	7
48	R:R:F418	R:R:T336	43.8688	5.19	Yes	Yes	0	8	7
49	R:R:F418	S:S:L362	42.7064	7.31	Yes	No	0	8	5
50	S:S:L362	S:S:S366	43.5403	1.5	No	No	0	5	7
51	R:R:L367	S:S:S366	43.8262	1.5	No	No	0	5	7
52	R:R:L367	R:R:P368	44.6985	1.64	No	No	0	5	9
53	R:R:P368	R:R:Y323	45.3976	6.95	No	No	0	9	8
54	R:R:L452	R:R:W535	15.3696	4.56	No	Yes	0	8	9
55	R:R:I293	R:R:V294	15.4693	3.07	No	No	0	8	8
56	R:R:F332	R:R:T336	15.8282	5.19	No	Yes	0	9	7
57	R:R:F403	S:S:F403	57.6691	6.43	Yes	Yes	1	8	8
58	S:S:F403	S:S:Y322	21.9464	5.16	Yes	Yes	1	8	9
59	S:S:T372	S:S:Y322	18.5693	6.24	No	Yes	0	9	9
60	S:S:T372	S:S:Y323	18.4032	4.99	No	Yes	0	9	8
61	S:S:W365	S:S:Y323	18.0414	6.75	Yes	Yes	0	9	8
62	S:S:A401	S:S:F474	40.7951	4.16	No	Yes	0	6	6
63	S:S:A401	S:S:G402	40.9003	1.95	No	No	0	6	5
64	R:R:A374	S:S:G402	41.112	1.95	No	No	0	5	5
65	R:R:A374	S:S:F403	41.224	4.16	No	Yes	0	5	8
66	S:S:G456	S:S:L419	12.4722	1.71	No	No	0	7	7
67	S:S:G456	S:S:L335	12.5987	1.71	No	No	0	7	8
68	S:S:I266	S:S:L335	12.2673	5.71	Yes	No	0	8	8
69	S:S:F474	S:S:Y397	41.3905	4.13	Yes	Yes	2	6	3
70	S:S:Q477	S:S:Y397	40.8036	6.76	Yes	Yes	2	6	3
71	M:M:?1	S:S:Q477	37.0611	7.45	Yes	Yes	2	0	6
72	M:M:?1	S:S:F484	11.3912	18.59	Yes	Yes	0	0	6
73	S:S:F484	S:S:V488	11.1002	3.93	Yes	No	0	6	6
74	M:M:?1	S:S:W281	13.3236	8.69	Yes	Yes	2	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F484	S:S:I215	5.02	0	Yes	No	6	5	1	2
S:S:N219	S:S:P220	4.89	2	Yes	No	7	8	1	2
S:S:L221	S:S:N219	4.12	0	No	Yes	6	7	2	1
S:S:F222	S:S:N219	8.46	2	Yes	Yes	6	7	2	1
S:S:D384	S:S:N219	5.39	2	Yes	Yes	8	7	1	1
S:S:N219	S:S:V386	4.43	2	Yes	Yes	7	5	1	2
M:M:?1	S:S:N219	6.99	2	Yes	Yes	0	7	0	1
S:S:F484	S:S:P220	7.22	0	Yes	No	6	8	1	2
S:S:F484	S:S:L221	8.53	0	Yes	No	6	6	1	2
S:S:F222	S:S:V386	5.24	2	Yes	Yes	6	5	2	2
S:S:F222	S:S:P513	7.22	2	Yes	No	6	8	2	1
S:S:I234	S:S:W281	5.87	2	Yes	Yes	7	7	2	1
S:S:V321	S:S:W281	7.36	2	No	Yes	8	7	2	1
S:S:I389	S:S:W281	11.74	2	Yes	Yes	9	7	2	1
S:S:L522	S:S:W281	4.56	2	No	Yes	7	7	1	1
S:S:M525	S:S:W281	4.65	2	No	Yes	5	7	2	1
S:S:F526	S:S:W281	10.02	2	Yes	Yes	9	7	2	1
M:M:?1	S:S:W281	8.69	2	Yes	Yes	0	7	0	1
S:S:I389	S:S:V321	6.14	2	Yes	No	9	8	2	2
S:S:D384	S:S:V386	7.3	2	Yes	Yes	8	5	1	2
S:S:D384	S:S:S387	7.36	2	Yes	Yes	8	8	1	1
S:S:D384	S:S:Y394	9.2	2	Yes	Yes	8	5	1	1
M:M:?1	S:S:D384	7.6	2	Yes	Yes	0	8	0	1
S:S:I389	S:S:S387	4.64	2	Yes	Yes	9	8	2	1
S:S:S387	S:S:Y394	6.36	2	Yes	Yes	8	5	1	1
M:M:?1	S:S:S387	4.58	2	Yes	Yes	0	8	0	1
S:S:F391	S:S:I389	3.77	2	Yes	Yes	8	9	1	2
S:S:F391	S:S:Y394	9.28	2	Yes	Yes	8	5	1	1
S:S:F391	S:S:V404	3.93	2	Yes	No	8	7	1	2
M:M:?1	S:S:F391	5.58	2	Yes	Yes	0	8	0	1
M:M:?1	S:S:Y394	11.93	2	Yes	Yes	0	5	0	1
S:S:Q477	S:S:Y397	6.76	2	Yes	Yes	6	3	1	2
S:S:E481	S:S:Y397	7.86	2	No	Yes	5	3	2	2
S:S:H470	S:S:R400	11.28	0	No	No	7	9	2	1
S:S:D473	S:S:R400	10.72	0	No	No	8	9	2	1
M:M:?1	S:S:R400	8.65	2	Yes	No	0	9	0	1
S:S:H470	S:S:V404	6.92	0	No	No	7	7	2	2
S:S:N521	S:S:T466	5.85	0	Yes	No	8	8	1	2
S:S:C469	S:S:N521	6.3	0	No	Yes	7	8	2	1
S:S:H470	S:S:N521	14.03	0	No	Yes	7	8	2	1
S:S:D473	S:S:W480	5.58	0	No	Yes	8	9	2	2
S:S:D473	S:S:E518	11.69	0	No	No	8	7	2	1
S:S:Q477	S:S:W480	5.48	2	Yes	Yes	6	9	1	2
S:S:E481	S:S:Q477	7.65	2	No	Yes	5	6	2	1
M:M:?1	S:S:Q477	7.45	2	Yes	Yes	0	6	0	1
S:S:P513	S:S:W480	17.57	0	No	Yes	8	9	1	2
S:S:F484	S:S:V488	3.93	0	Yes	No	6	6	1	2
M:M:?1	S:S:F484	18.59	2	Yes	Yes	0	6	0	1
M:M:?1	S:S:P513	12.53	2	Yes	No	0	8	0	1
M:M:?1	S:S:E518	28.32	2	Yes	No	0	7	0	1
M:M:?1	S:S:N521	4.89	2	Yes	Yes	0	8	0	1
S:S:F526	S:S:L522	4.87	2	Yes	No	9	7	2	1
M:M:?1	S:S:L522	5.63	2	Yes	No	0	7	0	1
S:S:F526	S:S:M525	11.2	2	Yes	No	9	5	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F484	R:R:I215	5.02	0	Yes	No	6	5	1	2
R:R:N219	R:R:P220	6.52	1	Yes	No	7	8	1	2
R:R:L221	R:R:N219	5.49	1	Yes	Yes	6	7	2	1
R:R:F222	R:R:N219	8.46	1	Yes	Yes	6	7	2	1
R:R:D384	R:R:N219	5.39	1	Yes	Yes	8	7	1	1
R:R:N219	R:R:V386	4.43	1	Yes	Yes	7	5	1	2
L:L:?1	R:R:N219	6.29	1	Yes	Yes	0	7	0	1
R:R:F484	R:R:P220	7.22	0	Yes	No	6	8	1	2
R:R:F222	R:R:L221	4.87	1	Yes	Yes	6	6	2	2
R:R:F484	R:R:L221	4.87	0	Yes	Yes	6	6	1	2
R:R:F222	R:R:V386	5.24	1	Yes	Yes	6	5	2	2
R:R:F222	R:R:P513	8.67	1	Yes	No	6	8	2	1
R:R:F222	R:R:L515	13.4	1	Yes	No	6	5	2	2
R:R:I234	R:R:M230	5.83	0	No	Yes	7	7	2	1
R:R:L515	R:R:M230	5.65	0	No	Yes	5	7	2	1
R:R:K519	R:R:M230	4.32	0	No	Yes	7	7	2	1
L:L:?1	R:R:M230	4.32	1	Yes	Yes	0	7	0	1
R:R:I234	R:R:W281	5.87	0	No	Yes	7	7	2	1
R:R:V321	R:R:W281	8.58	1	No	Yes	8	7	2	1
R:R:I389	R:R:W281	12.92	1	No	Yes	9	7	2	1
R:R:L522	R:R:W281	5.69	1	No	Yes	7	7	1	1
R:R:F526	R:R:W281	8.02	1	Yes	Yes	9	7	2	1
L:L:?1	R:R:W281	7.53	1	Yes	Yes	0	7	0	1
R:R:I389	R:R:V321	6.14	1	No	No	9	8	2	2
R:R:D382	R:R:Y394	5.75	0	No	Yes	9	5	2	1
R:R:D382	R:R:K395	4.15	0	No	No	9	3	2	1
R:R:D384	R:R:V386	8.76	1	Yes	Yes	8	5	1	2
R:R:D384	R:R:S387	7.36	1	Yes	No	8	8	1	1
R:R:D384	R:R:Y394	9.2	1	Yes	Yes	8	5	1	1
L:L:?1	R:R:D384	7.6	1	Yes	Yes	0	8	0	1
R:R:S387	R:R:Y394	6.36	1	No	Yes	8	5	1	1
L:L:?1	R:R:S387	4.58	1	Yes	No	0	8	0	1
R:R:F391	R:R:I389	3.77	1	Yes	No	8	9	1	2
R:R:F391	R:R:V392	3.93	1	Yes	Yes	8	9	1	2
R:R:F391	R:R:Y394	8.25	1	Yes	Yes	8	5	1	1
R:R:F391	R:R:V404	5.24	1	Yes	No	8	7	1	2
L:L:?1	R:R:F391	4.96	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y394	11.93	1	Yes	Yes	0	5	0	1
R:R:K395	R:R:N396	8.39	0	No	No	3	7	1	2
L:L:?1	R:R:K395	4.31	1	Yes	No	0	3	0	1
R:R:Q477	R:R:Y397	6.76	1	Yes	Yes	6	3	1	2
R:R:E481	R:R:Y397	6.73	1	No	Yes	5	3	2	2
R:R:H470	R:R:R400	10.16	0	No	No	7	9	2	1
R:R:D473	R:R:R400	11.91	0	No	No	8	9	2	1
L:L:?1	R:R:R400	8.04	1	Yes	No	0	9	0	1
R:R:H470	R:R:V404	6.92	0	No	No	7	7	2	2
R:R:N521	R:R:T466	4.39	0	Yes	No	8	8	1	2
R:R:C469	R:R:N521	6.3	0	No	Yes	7	8	2	1
R:R:H470	R:R:N521	14.03	0	No	Yes	7	8	2	1
R:R:D473	R:R:W480	5.58	0	No	Yes	8	9	2	2
R:R:D473	R:R:E518	11.69	0	No	No	8	7	2	1
R:R:Q477	R:R:W480	5.48	1	Yes	Yes	6	9	1	2
R:R:E481	R:R:Q477	11.47	1	No	Yes	5	6	2	1
L:L:?1	R:R:Q477	8.81	1	Yes	Yes	0	6	0	1
R:R:P513	R:R:W480	22.97	0	No	Yes	8	9	1	2
L:L:?1	R:R:F484	13.02	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:P513	11.7	1	Yes	No	0	8	0	1
L:L:?1	R:R:E518	25.62	1	Yes	No	0	7	0	1
L:L:?1	R:R:N521	5.59	1	Yes	Yes	0	8	0	1
R:R:F526	R:R:L522	7.31	1	Yes	No	9	7	2	1
L:L:?1	R:R:L522	5.63	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	4JKV_poly
Class	F
SubFamily	Protein
Type	Frizzled
SubType	SMO
Species	Homo sapiens
Ligand	Taladegib (LY2940680)
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.45
Date	2013-04-24
D.O.I.	10.1038/nature12167

Net Summary
I_min	3.71
Number of Linked Nodes	653
Number of Links	790
Number of Hubs	117
Number of Links mediated by Hubs	441
Number of Communities	18
Number of Nodes involved in Communities	171
Number of Links involved in Communities	257

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	768578
Length Of Smallest Path	3
Average Path Length	24.4969
Length of Longest Path	50
Minimum Path Strength	1.19
Average Path Strength	6.45645
Maximum Path Strength	23.455
Minimum Path Correlation	0.7
Average Path Correlation	0.965281
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	49.2353
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.2357
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	1KS
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	1KS
Name	Taladegib
Synonyms	Taladegib
Identifier	4-fluoranyl-N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-2-(trifluoromethyl)benzamide
Formula	C26 H24 F4 N6 O
Molecular Weight	512.502
SMILES	Cn1c(ccn1)c2c3ccccc3c(nn2)N4CCC(CC4)N(C)C(=O)c5ccc(cc5C(F)(F)F)F
PubChem	49848070
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	0
Total Bonds	65
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>4JKV_poly_Chain_R S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R L G E P T S N E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T K A T L L I W R R T W C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib (LY2940680)	-	-	2.45	2013-04-24	10.1038/nature12167
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	10.1038/ncomms4309
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	PubChem 24905375	-	-	2.61	2014-07-23	10.1038/ncomms5355
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	10.1038/ncomms5355
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	10.1038/nature18934
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	10.1038/nature18934
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	10.1038/ncomms15383
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	10.1038/ncomms15383
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	10.1016/j.cell.2018.04.029
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	10.1038/s41586-019-1355-4
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/&β;1/&γ;2	3.84	2019-06-12	10.1038/s41586-019-1286-0
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/&β;1/&γ;2	3.88	2020-09-30	10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/&β;1/&γ;2	3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/&β;1/&γ;2	3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/&β;1/&γ;2	3.14	2020-09-30	10.1038/s41589-020-0646-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	10.1126/sciadv.abm5563
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	10.1038/s41467-022-32125-2
	4JKV (Dimer)	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib (LY2940680)	-	-	2.45	2013-04-24	10.1038/nature12167

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4JKV_poly.zip

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