psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W151	8.01	Yes	Yes	3	0	5
2	L:L:?1	R:R:D155	16.97	Yes	Yes	3	0	8
3	L:L:?1	R:R:V156	16.3	Yes	No	0	0	6
4	L:L:?1	R:R:S159	3.52	Yes	No	3	0	7
5	L:L:?1	R:R:L229	6.49	Yes	Yes	3	0	4
6	L:L:?1	R:R:F234	2.86	Yes	Yes	3	0	7
7	L:L:?1	R:R:S242	5.87	Yes	No	0	0	6
8	L:L:?1	R:R:W336	2.67	Yes	Yes	3	0	8
9	L:L:?1	R:R:F339	20.95	Yes	Yes	3	0	7
10	L:L:?1	R:R:F340	10.47	Yes	Yes	3	0	7
11	L:L:?1	R:R:N343	3.22	Yes	Yes	3	0	7
12	L:L:?1	R:R:Y370	2.75	Yes	Yes	3	0	7
13	M:M:?1	S:S:W151	4.45	Yes	Yes	2	0	5
14	M:M:?1	S:S:D155	23.34	Yes	Yes	2	0	8
15	M:M:?1	S:S:V156	17.47	Yes	Yes	2	0	6
16	M:M:?1	S:S:S159	9.39	Yes	No	2	0	7
17	M:M:?1	S:S:L229	5.41	Yes	Yes	0	0	4
18	M:M:?1	S:S:G238	4.01	Yes	No	0	0	6
19	M:M:?1	S:S:S239	8.22	Yes	Yes	2	0	6
20	M:M:?1	S:S:S242	4.7	Yes	No	0	0	6
21	M:M:?1	S:S:W336	2.67	Yes	Yes	2	0	8
22	M:M:?1	S:S:F339	13.33	Yes	Yes	2	0	7
23	M:M:?1	S:S:F340	9.52	Yes	Yes	2	0	7
24	M:M:?1	S:S:N343	5.37	Yes	Yes	2	0	7
25	M:M:?1	S:S:V366	3.49	Yes	Yes	2	0	6
26	P:P:L69	P:P:Q72	6.65	No	No	0	7	1
27	P:P:E73	P:P:H70	12.31	No	No	0	3	3
28	P:P:H70	P:P:K74	3.93	No	No	0	3	6
29	P:P:L71	P:P:Q72	3.99	No	No	0	3	1
30	P:P:L71	P:P:N75	5.49	No	No	0	3	5
31	P:P:L80	P:P:V83	4.47	No	No	0	4	4
32	P:P:M132	P:P:T81	7.53	No	No	0	6	6
33	P:P:T81	P:P:W367	10.92	No	Yes	0	6	6
34	P:P:M128	P:P:V84	3.04	Yes	No	0	8	7
35	P:P:A371	P:P:V84	3.39	No	No	0	4	7
36	P:P:I85	P:P:M128	2.92	No	Yes	0	6	8
37	P:P:I85	P:P:P129	8.47	No	No	0	6	8
38	P:P:I89	P:P:T88	3.04	No	Yes	0	5	7
39	P:P:G124	P:P:T88	3.64	No	Yes	1	6	7
40	P:P:M128	P:P:T88	6.02	Yes	Yes	1	8	7
41	P:P:S373	P:P:T88	3.2	No	Yes	1	9	7
42	P:P:A374	P:P:T88	3.36	No	Yes	0	6	7
43	P:P:G91	P:P:P377	4.06	No	No	0	8	9
44	P:P:A117	P:P:N92	4.69	No	No	0	9	9
45	P:P:D120	P:P:N92	8.08	Yes	No	0	9	9
46	P:P:N92	P:P:P377	9.77	No	No	0	9	9
47	P:P:I93	P:P:M121	2.92	No	No	0	3	7
48	P:P:F391	P:P:L94	10.96	Yes	No	0	6	6
49	P:P:A117	P:P:V95	3.39	No	Yes	0	9	9
50	P:P:P377	P:P:V95	3.53	No	Yes	0	9	9
51	P:P:V95	P:P:Y380	3.79	Yes	Yes	0	9	9
52	P:P:F391	P:P:V95	5.24	Yes	Yes	0	6	9
53	P:P:I96	P:P:M114	2.92	No	No	0	6	5
54	P:P:L101	P:P:M97	2.83	No	No	7	5	4
55	P:P:M97	P:P:Y394	4.79	No	Yes	7	4	4
56	P:P:A98	P:P:Y387	2.67	No	Yes	0	7	8
57	P:P:A98	P:P:Y394	5.34	No	Yes	0	7	4
58	P:P:V99	P:P:Y111	2.52	No	Yes	0	7	4
59	P:P:M114	P:P:V99	9.13	No	No	0	5	7
60	P:P:V99	P:P:Y387	2.52	No	Yes	0	7	8
61	P:P:L101	P:P:Y394	9.38	No	Yes	7	5	4
62	P:P:E102	P:P:K104	16.2	No	No	0	6	6
63	P:P:E102	P:P:L105	2.65	No	Yes	0	6	8
64	P:P:E102	P:P:R393	3.49	No	Yes	0	6	4
65	P:P:K104	P:P:T386	4.5	No	No	0	6	6
66	P:P:L105	P:P:N110	5.49	Yes	No	1	8	9
67	P:P:L105	P:P:T386	4.42	Yes	No	0	8	6
68	P:P:L105	P:P:Y387	15.24	Yes	Yes	1	8	8
69	P:P:Q106	P:P:Y111	10.15	No	Yes	0	7	4
70	P:P:N107	P:P:N110	9.54	No	No	0	7	9
71	P:P:L113	P:P:T109	2.95	No	No	0	8	8
72	P:P:R173	P:P:T109	3.88	Yes	No	0	9	8
73	P:P:N110	P:P:Y387	8.14	No	Yes	1	9	8
74	P:P:R189	P:P:Y111	10.29	Yes	Yes	8	4	4
75	P:P:A192	P:P:Y111	4	No	Yes	0	7	4
76	P:P:F193	P:P:Y111	7.22	No	Yes	8	4	4
77	P:P:F112	P:P:I169	10.05	No	No	0	8	9
78	P:P:D172	P:P:F112	4.78	No	No	9	9	8
79	P:P:F112	P:P:K195	9.93	No	No	9	8	6
80	P:P:I169	P:P:L113	2.85	No	No	0	9	8
81	P:P:L113	P:P:Y380	9.38	No	Yes	0	8	9
82	P:P:H165	P:P:S115	9.76	Yes	No	1	8	9
83	P:P:I196	P:P:S115	7.74	No	No	0	8	9
84	P:P:S115	P:P:W200	4.94	No	Yes	1	9	9
85	P:P:D120	P:P:L116	5.43	Yes	Yes	1	9	9
86	P:P:H165	P:P:L116	6.43	Yes	Yes	1	8	9
87	P:P:L116	P:P:L166	4.15	Yes	Yes	1	9	8
88	P:P:L116	P:P:N376	5.49	Yes	Yes	1	9	9
89	P:P:I118	P:P:L122	2.85	No	No	0	6	7
90	P:P:A119	P:P:F158	2.77	No	Yes	1	8	7
91	P:P:A119	P:P:W200	3.89	No	Yes	1	8	9
92	P:P:D120	P:P:S162	2.94	Yes	No	0	9	9
93	P:P:D120	P:P:S373	8.83	Yes	No	1	9	9
94	P:P:D120	P:P:N376	4.04	Yes	Yes	1	9	9
95	P:P:F158	P:P:L122	9.74	Yes	No	0	7	7
96	P:P:L123	P:P:V127	4.47	No	Yes	1	7	8
97	P:P:D155	P:P:L123	4.07	Yes	No	1	8	7
98	P:P:F158	P:P:L123	4.87	Yes	No	1	7	7
99	P:P:G124	P:P:M128	5.24	No	Yes	1	6	8
100	P:P:F125	P:P:L126	7.31	No	No	0	4	5
101	P:P:V127	P:P:W151	8.58	Yes	Yes	1	8	5
102	P:P:D155	P:P:V127	10.22	Yes	Yes	1	8	8
103	P:P:V127	P:P:Y370	2.52	Yes	Yes	1	8	7
104	P:P:M128	P:P:W367	6.98	Yes	Yes	1	8	6
105	P:P:M128	P:P:Y370	8.38	Yes	Yes	1	8	7
106	P:P:M128	P:P:S373	3.07	Yes	No	1	8	9
107	P:P:L143	P:P:V130	4.47	Yes	No	0	5	4
108	P:P:V130	P:P:W151	8.58	No	Yes	0	4	5
109	P:P:S131	P:P:W151	4.94	No	Yes	1	7	5
110	P:P:S131	P:P:W367	3.71	No	Yes	1	7	6
111	P:P:S131	P:P:Y370	5.09	No	Yes	1	7	7
112	P:P:I135	P:P:M132	2.92	No	No	0	5	6
113	P:P:L133	P:P:P142	6.57	No	Yes	0	4	3
114	P:P:P142	P:P:T134	5.25	Yes	No	0	3	5
115	P:P:I135	P:P:Y139	8.46	No	No	0	5	3
116	P:P:L136	P:P:Y137	3.52	No	No	0	5	4
117	P:P:P142	P:P:Y137	6.95	Yes	No	0	3	4
118	P:P:N363	P:P:Y139	15.12	No	No	0	4	3
119	P:P:G225	P:P:R140	3	No	No	0	3	4
120	P:P:P142	P:P:W141	5.4	Yes	Yes	1	3	7
121	P:P:L143	P:P:W141	14.81	Yes	Yes	1	5	7
122	P:P:C148	P:P:W141	10.45	Yes	Yes	1	9	7
123	P:P:W141	P:P:W151	12.18	Yes	Yes	1	7	5
124	P:P:F222	P:P:W141	6.01	No	Yes	1	2	7
125	P:P:C227	P:P:W141	11.75	Yes	Yes	1	9	7
126	P:P:L143	P:P:P142	4.93	Yes	Yes	1	5	3
127	P:P:L143	P:P:P144	4.93	Yes	No	0	5	7
128	P:P:F222	P:P:S145	2.64	No	No	0	2	3
129	P:P:K146	P:P:L147	5.64	No	No	0	1	5
130	P:P:L147	P:P:V150	5.96	No	No	0	5	4
131	P:P:C148	P:P:V221	3.42	Yes	No	0	9	3
132	P:P:C148	P:P:F222	6.98	Yes	No	1	9	2
133	P:P:C148	P:P:C227	7.28	Yes	Yes	1	9	9
134	P:P:A149	P:P:V221	5.09	No	No	0	6	3
135	P:P:C227	P:P:W151	5.22	Yes	Yes	1	9	5
136	P:P:W151	U:U:?1	2.67	Yes	Yes	1	5	0
137	P:P:I152	P:P:I210	2.94	No	Yes	0	5	6
138	P:P:C227	P:P:I152	3.27	Yes	No	0	9	5
139	P:P:I152	P:P:L229	4.28	No	Yes	0	5	4
140	P:P:L157	P:P:Y153	5.86	Yes	No	1	6	6
141	P:P:S207	P:P:Y153	8.9	No	No	1	7	6
142	P:P:P211	P:P:Y153	8.34	No	No	0	5	6
143	P:P:D155	P:P:Y370	10.34	Yes	Yes	1	8	7
144	P:P:D155	U:U:?1	9.55	Yes	Yes	1	8	0
145	P:P:I210	P:P:V156	4.61	Yes	No	0	6	6
146	P:P:V156	U:U:?1	10.48	No	Yes	0	6	0
147	P:P:F158	P:P:L157	3.65	Yes	Yes	1	7	6
148	P:P:L157	P:P:V204	2.98	Yes	No	0	6	4
149	P:P:L157	P:P:S207	9.01	Yes	No	1	6	7
150	P:P:F158	P:P:W200	4.01	Yes	Yes	1	7	9
151	P:P:S159	P:P:W336	3.71	No	Yes	1	7	8
152	P:P:S159	U:U:?1	7.04	No	Yes	1	7	0
153	P:P:I206	P:P:T160	4.56	No	No	0	6	7
154	P:P:S242	P:P:T160	6.4	No	No	0	6	7
155	P:P:A161	P:P:H165	2.93	No	Yes	1	8	8
156	P:P:A161	P:P:W200	5.19	No	Yes	1	8	9
157	P:P:A161	P:P:S203	3.42	No	No	0	8	8
158	P:P:F332	P:P:S162	2.64	Yes	No	0	9	9
159	P:P:I163	P:P:P246	5.08	Yes	No	0	8	9
160	P:P:I163	P:P:M250	2.92	Yes	Yes	0	8	8
161	P:P:F332	P:P:I163	8.79	Yes	Yes	0	9	8
162	P:P:M164	P:P:S203	3.07	No	No	0	6	8
163	P:P:M164	P:P:P246	3.35	No	No	0	6	9
164	P:P:H165	P:P:V199	8.3	Yes	No	0	8	6
165	P:P:H165	P:P:W200	9.52	Yes	Yes	1	8	9
166	P:P:L166	P:P:M250	7.07	Yes	Yes	1	8	8
167	P:P:F329	P:P:L166	7.31	Yes	Yes	1	8	8
168	P:P:F332	P:P:L166	4.87	Yes	Yes	1	9	8
169	P:P:C167	P:P:L171	3.17	No	No	1	6	6
170	P:P:C167	P:P:I249	3.27	No	No	1	6	6
171	P:P:C167	P:P:M250	3.24	No	Yes	1	6	8
172	P:P:I169	P:P:L325	2.85	No	No	0	9	8
173	P:P:S170	P:P:T253	7.99	No	No	0	9	5
174	P:P:F329	P:P:S170	3.96	Yes	No	0	8	9
175	P:P:I249	P:P:L171	4.28	No	No	1	6	6
176	P:P:L171	P:P:T253	2.95	No	No	0	6	5
177	P:P:D172	P:P:K195	8.3	No	No	9	9	6
178	P:P:E318	P:P:R173	11.63	No	Yes	0	8	9
179	P:P:A321	P:P:R173	2.77	No	Yes	0	8	9
180	P:P:C322	P:P:R173	2.79	No	Yes	0	7	9
181	P:P:L325	P:P:R173	3.64	No	Yes	0	8	9
182	P:P:T257	P:P:Y174	8.74	No	No	0	9	8
183	P:P:Q178	P:P:V175	10.03	No	No	0	6	5
184	P:P:I177	P:P:T257	3.04	No	No	0	9	9
185	P:P:I177	P:P:S260	10.84	No	No	0	9	6
186	P:P:E264	P:P:I177	9.56	No	No	0	7	9
187	P:P:H183	P:P:N179	2.55	No	No	0	7	6
188	P:P:N187	P:P:S184	2.98	No	No	0	6	6
189	P:P:F186	P:P:R185	3.21	No	No	0	4	4
190	P:P:R185	P:P:S188	2.64	No	No	0	4	7
191	P:P:F186	P:P:R189	4.28	No	Yes	0	4	4
192	P:P:F186	S:S:Q398	8.2	No	No	0	4	4
193	P:P:K191	P:P:N187	4.2	No	No	0	6	6
194	P:P:F193	P:P:R189	4.28	No	Yes	8	4	4
195	P:P:R189	S:S:Q396	18.69	Yes	No	0	4	4
196	P:P:T190	S:S:S392	6.4	No	No	0	5	3
197	P:P:T190	S:S:I395	6.08	No	No	0	5	6
198	P:P:T190	S:S:Q396	5.67	No	No	0	5	4
199	P:P:K191	P:P:K195	5.75	No	No	0	6	6
200	P:P:M208	S:S:K74	2.88	No	No	0	4	6
201	P:P:M208	S:S:N75	8.41	No	Yes	0	4	5
202	P:P:I210	P:P:P209	5.08	Yes	No	10	6	7
203	P:P:F234	P:P:P209	13	Yes	No	10	7	7
204	P:P:F234	P:P:I210	6.28	Yes	Yes	10	7	6
205	P:P:V212	S:S:K74	3.04	No	No	0	5	6
206	P:P:D217	P:P:F213	9.55	Yes	No	12	6	4
207	P:P:F213	P:P:K220	7.44	No	Yes	12	4	3
208	P:P:L215	P:P:Q216	5.32	No	No	0	5	6
209	P:P:D217	P:P:S219	4.42	Yes	No	0	6	3
210	P:P:D217	P:P:K220	5.53	Yes	Yes	12	6	3
211	P:P:D217	P:P:V221	2.92	Yes	No	0	6	3
212	P:P:K220	P:P:L229	4.23	Yes	Yes	0	3	4
213	P:P:D231	P:P:K220	6.91	No	Yes	0	5	3
214	P:P:K223	P:P:L228	2.82	No	No	0	3	4
215	P:P:A230	P:P:K223	3.21	No	No	0	3	3
216	P:P:E355	P:P:K223	4.05	No	No	0	3	3
217	P:P:L228	P:P:S226	4.5	No	No	0	4	4
218	P:P:L228	U:U:?1	3.25	No	Yes	0	4	0
219	P:P:F234	P:P:L229	4.87	Yes	Yes	0	7	4
220	P:P:L229	P:P:V235	4.47	Yes	No	0	4	6
221	P:P:L229	U:U:?1	7.57	Yes	Yes	0	4	0
222	P:P:D231	P:P:N233	5.39	No	No	0	5	3
223	P:P:D232	P:P:V347	5.84	No	No	0	4	5
224	P:P:D232	P:P:K350	2.77	No	No	0	4	1
225	P:P:F234	P:P:G238	3.01	Yes	No	0	7	6
226	P:P:N343	P:P:V235	4.43	Yes	No	0	7	6
227	P:P:V235	P:P:V347	4.81	No	No	0	6	5
228	P:P:L236	P:P:V347	2.98	No	No	0	6	5
229	P:P:G238	P:P:I237	3.53	No	No	0	6	4
230	P:P:I237	P:P:V241	3.07	No	No	0	4	4
231	P:P:G238	U:U:?1	2.67	No	Yes	0	6	0
232	P:P:F340	P:P:S239	3.96	Yes	No	0	7	6
233	P:P:I344	P:P:S239	4.64	No	No	0	5	6
234	P:P:F240	P:P:F244	9.65	No	No	0	4	5
235	P:P:S242	U:U:?1	4.7	No	Yes	0	6	0
236	P:P:F243	P:P:F244	6.43	Yes	No	0	8	5
237	P:P:F243	P:P:F332	3.22	Yes	Yes	1	8	9
238	P:P:F243	P:P:W336	4.01	Yes	Yes	1	8	8
239	P:P:C337	P:P:F243	6.98	No	Yes	0	6	8
240	P:P:F243	P:P:F340	18.22	Yes	Yes	1	8	7
241	P:P:I245	P:P:P246	5.08	No	No	0	5	9
242	P:P:A247	P:P:V333	3.39	No	No	0	6	6
243	P:P:F329	P:P:M250	7.46	Yes	Yes	1	8	8
244	P:P:F255	P:P:V251	2.62	No	No	0	1	5
245	P:P:I252	P:P:L256	2.85	No	No	0	5	5
246	P:P:F255	P:P:Y254	6.19	No	No	0	1	9
247	P:P:G326	P:P:Y254	7.24	No	No	0	6	9
248	P:P:F329	P:P:Y254	6.19	Yes	No	0	8	9
249	P:P:K259	P:P:Q262	9.49	No	No	0	4	6
250	P:P:E318	P:P:L261	2.65	No	No	0	8	8
251	P:P:L261	P:P:Q319	2.66	No	No	0	8	5
252	P:P:A265	P:P:I315	4.87	No	No	0	5	5
253	P:P:M312	P:P:T311	3.01	No	No	0	4	4
254	P:P:N317	P:P:Q313	2.64	No	No	0	6	5
255	P:P:I315	P:P:Q319	8.23	No	No	0	5	5
256	P:P:Q319	P:P:S316	4.33	No	No	0	5	6
257	P:P:K320	P:P:K323	5.75	No	No	0	8	7
258	P:P:I327	P:P:K323	2.91	No	No	0	6	7
259	P:P:F383	P:P:V324	3.93	No	No	0	7	8
260	P:P:I327	P:P:V379	3.07	No	No	0	6	8
261	P:P:F383	P:P:I327	5.02	No	No	0	7	6
262	P:P:N376	P:P:V328	5.91	Yes	No	1	9	8
263	P:P:V328	P:P:V379	4.81	No	No	1	8	8
264	P:P:V328	P:P:Y380	2.52	No	Yes	1	8	9
265	P:P:F330	P:P:L331	3.65	No	No	0	5	6
266	P:P:F330	P:P:V334	13.11	No	No	0	5	5
267	P:P:L331	P:P:V375	4.47	No	No	0	6	6
268	P:P:F332	P:P:W336	9.02	Yes	Yes	1	9	8
269	P:P:F332	P:P:S372	2.64	Yes	No	1	9	9
270	P:P:I368	P:P:M335	2.92	No	No	0	7	8
271	P:P:M335	P:P:S372	6.13	No	No	0	8	9
272	P:P:M335	P:P:V375	3.04	No	No	0	8	6
273	P:P:F339	P:P:W336	8.02	Yes	Yes	1	7	8
274	P:P:F340	P:P:W336	8.02	Yes	Yes	1	7	8
275	P:P:G369	P:P:W336	9.85	No	Yes	0	7	8
276	P:P:W336	P:P:Y370	3.86	Yes	Yes	1	8	7
277	P:P:S372	P:P:W336	6.18	No	Yes	1	9	8
278	P:P:W336	U:U:?1	2.67	Yes	Yes	1	8	0
279	P:P:F365	P:P:P338	10.11	Yes	No	0	5	9
280	P:P:F339	P:P:F340	7.5	Yes	Yes	1	7	7
281	P:P:F339	P:P:N343	9.67	Yes	Yes	1	7	7
282	P:P:F339	P:P:L362	6.09	Yes	Yes	1	7	3
283	P:P:F339	P:P:V366	7.87	Yes	No	1	7	6
284	P:P:F339	U:U:?1	12.38	Yes	Yes	1	7	0
285	P:P:F340	P:P:N343	3.62	Yes	Yes	1	7	7
286	P:P:F340	U:U:?1	16.19	Yes	Yes	1	7	0
287	P:P:L362	P:P:T342	4.42	Yes	No	0	3	5
288	P:P:F365	P:P:T342	5.19	Yes	No	0	5	5
289	P:P:L362	P:P:N343	6.87	Yes	Yes	1	3	7
290	P:P:N343	U:U:?1	3.22	Yes	Yes	1	7	0
291	P:P:I344	P:P:I348	2.94	No	No	0	5	4
292	P:P:A346	P:P:E355	3.02	No	No	0	4	3
293	P:P:C349	P:P:C353	7.28	No	No	0	3	3
294	P:P:E351	P:P:S352	2.87	No	No	0	5	2
295	P:P:D356	P:P:N354	10.77	No	No	0	2	1
296	P:P:N354	P:P:V357	5.91	No	No	0	1	5
297	P:P:L361	P:P:V357	2.98	No	No	0	4	5
298	P:P:F365	P:P:L361	8.53	Yes	No	0	5	4
299	P:P:L362	U:U:?1	4.33	Yes	Yes	1	3	0
300	P:P:N363	U:U:?1	3.22	No	Yes	0	4	0
301	P:P:F365	P:P:V364	2.62	Yes	No	0	5	4
302	P:P:V366	P:P:Y370	8.83	No	Yes	1	6	7
303	P:P:V366	U:U:?1	3.49	No	Yes	1	6	0
304	P:P:W367	P:P:Y370	19.29	Yes	Yes	1	6	7
305	P:P:Y370	U:U:?1	4.58	Yes	Yes	1	7	0
306	P:P:N376	P:P:Y380	6.98	Yes	Yes	1	9	9
307	P:P:V379	P:P:Y380	2.52	No	Yes	1	8	9
308	P:P:Y380	P:P:Y387	5.96	Yes	Yes	1	9	8
309	P:P:F391	P:P:T381	6.49	Yes	No	0	6	7
310	P:P:F383	P:P:L382	8.53	No	No	0	7	5
311	P:P:N384	P:P:T386	7.31	No	No	0	9	6
312	P:P:N384	P:P:Y387	10.47	No	Yes	0	9	8
313	P:P:K385	P:P:R388	12.38	No	No	0	5	9
314	P:P:K385	P:P:S389	9.18	No	No	0	5	4
315	P:P:F391	P:P:Y387	3.09	Yes	Yes	0	6	8
316	P:P:A390	P:P:R393	4.15	No	Yes	0	7	4
317	P:P:A390	P:P:Y394	5.34	No	Yes	0	7	4
318	P:P:Q398	P:P:R393	4.67	No	Yes	0	4	4
319	P:P:Q396	P:P:Q398	2.56	No	No	0	4	4
320	R:R:E73	R:R:K74	6.75	No	No	0	3	6
321	R:R:E73	R:R:S77	2.87	No	No	0	3	3
322	R:R:N75	S:S:P209	8.15	No	No	0	5	7
323	R:R:A82	R:R:L79	4.73	No	No	0	3	4
324	R:R:L80	R:R:V83	2.98	No	No	0	4	4
325	R:R:M132	R:R:T81	12.04	Yes	No	0	6	6
326	R:R:T81	R:R:W367	10.92	No	Yes	0	6	6
327	R:R:A82	R:R:M132	3.22	No	Yes	0	3	6
328	R:R:L87	R:R:V83	2.98	No	No	0	4	4
329	R:R:V84	R:R:W367	3.68	No	Yes	0	7	6
330	R:R:A371	R:R:V84	5.09	No	No	0	4	7
331	R:R:I85	R:R:M128	4.37	No	Yes	0	6	8
332	R:R:I85	R:R:P129	3.39	No	No	0	6	8
333	R:R:M128	R:R:T88	4.52	Yes	No	3	8	7
334	R:R:S373	R:R:T88	3.2	No	No	3	9	7
335	R:R:A374	R:R:T88	3.36	No	No	0	6	7
336	R:R:F125	R:R:I89	8.79	No	No	0	4	5
337	R:R:G91	R:R:L94	3.42	No	Yes	0	8	6
338	R:R:G91	R:R:P377	4.06	No	No	0	8	9
339	R:R:I96	R:R:N92	2.83	Yes	Yes	13	6	9
340	R:R:A117	R:R:N92	4.69	No	Yes	0	9	9
341	R:R:D120	R:R:N92	10.77	No	Yes	0	9	9
342	R:R:M121	R:R:N92	5.61	No	Yes	13	7	9
343	R:R:I93	R:R:L94	2.85	No	Yes	0	3	6
344	R:R:I93	R:R:M121	8.75	No	No	0	3	7
345	R:R:F391	R:R:L94	9.74	Yes	Yes	0	6	6
346	R:R:I395	R:R:L94	5.71	No	Yes	0	6	6
347	R:R:A117	R:R:V95	3.39	No	Yes	0	9	9
348	R:R:P377	R:R:V95	3.53	No	Yes	0	9	9
349	R:R:V95	R:R:Y380	3.79	Yes	Yes	5	9	9
350	R:R:V95	R:R:Y387	2.52	Yes	Yes	5	9	8
351	R:R:F391	R:R:V95	5.24	Yes	Yes	5	6	9
352	R:R:I96	R:R:M114	4.37	Yes	No	0	6	5
353	R:R:I118	R:R:I96	5.89	No	Yes	0	6	6
354	R:R:I96	R:R:M121	2.92	Yes	No	13	6	7
355	R:R:M97	R:R:Y394	4.79	No	Yes	0	4	4
356	R:R:A98	R:R:Y387	2.67	No	Yes	5	7	8
357	R:R:A98	R:R:F391	2.77	No	Yes	5	7	6
358	R:R:A98	R:R:Y394	5.34	No	Yes	0	7	4
359	R:R:M114	R:R:V99	9.13	No	No	0	5	7
360	R:R:V99	R:R:Y387	3.79	No	Yes	0	7	8
361	R:R:L101	R:R:S100	3	No	No	0	5	1
362	R:R:L101	R:R:Y394	9.38	No	Yes	0	5	4
363	R:R:E102	R:R:R393	5.82	No	Yes	0	6	4
364	R:R:L105	R:R:T386	11.79	No	No	5	8	6
365	R:R:L105	R:R:Y387	8.21	No	Yes	5	8	8
366	R:R:N107	R:R:T109	2.92	No	No	0	7	8
367	R:R:R173	R:R:T109	5.17	Yes	No	0	9	8
368	R:R:L113	R:R:N110	5.49	No	No	0	8	9
369	R:R:N110	R:R:Y387	8.14	No	Yes	0	9	8
370	R:R:A192	R:R:Y111	4	No	No	0	7	4
371	R:R:A168	R:R:F112	2.77	No	Yes	0	7	8
372	R:R:F112	R:R:I169	8.79	Yes	No	0	8	9
373	R:R:D172	R:R:F112	3.58	No	Yes	14	9	8
374	R:R:F112	R:R:K195	4.96	Yes	No	14	8	6
375	R:R:F112	R:R:I196	3.77	Yes	No	0	8	8
376	R:R:L113	R:R:Y380	11.72	No	Yes	0	8	9
377	R:R:H165	R:R:S115	8.37	Yes	No	15	8	9
378	R:R:I196	R:R:S115	10.84	No	No	0	8	9
379	R:R:S115	R:R:W200	4.94	No	Yes	15	9	9
380	R:R:H165	R:R:L116	6.43	Yes	No	0	8	9
381	R:R:L116	R:R:L166	2.77	No	Yes	0	9	8
382	R:R:I118	R:R:L122	4.28	No	No	0	6	7
383	R:R:A119	R:R:W200	3.89	No	Yes	0	8	9
384	R:R:D120	R:R:S373	8.83	No	No	0	9	9
385	R:R:D120	R:R:N376	2.69	No	Yes	0	9	9
386	R:R:F158	R:R:L122	13.4	Yes	No	0	7	7
387	R:R:L123	R:R:V127	4.47	Yes	Yes	3	7	8
388	R:R:D155	R:R:L123	2.71	Yes	Yes	3	8	7
389	R:R:F158	R:R:L123	8.53	Yes	Yes	0	7	7
390	R:R:L123	R:R:S159	4.5	Yes	No	3	7	7
391	R:R:L123	R:R:Y370	5.86	Yes	Yes	3	7	7
392	R:R:G124	R:R:M128	5.24	No	Yes	0	6	8
393	R:R:F125	R:R:L126	3.65	No	No	0	4	5
394	R:R:L126	R:R:L154	5.54	No	No	0	5	5
395	R:R:F158	R:R:L126	3.65	Yes	No	0	7	5
396	R:R:V127	R:R:W151	6.13	Yes	Yes	3	8	5
397	R:R:L154	R:R:V127	2.98	No	Yes	0	5	8
398	R:R:D155	R:R:V127	8.76	Yes	Yes	3	8	8
399	R:R:V127	R:R:Y370	5.05	Yes	Yes	3	8	7
400	R:R:M128	R:R:W367	4.65	Yes	Yes	3	8	6
401	R:R:M128	R:R:Y370	11.97	Yes	Yes	3	8	7
402	R:R:M128	R:R:S373	3.07	Yes	No	3	8	9
403	R:R:V130	R:R:W141	3.68	No	Yes	3	4	7
404	R:R:V130	R:R:W151	17.16	No	Yes	3	4	5
405	R:R:S131	R:R:W151	4.94	No	Yes	3	7	5
406	R:R:S131	R:R:W367	7.41	No	Yes	3	7	6
407	R:R:S131	R:R:Y370	6.36	No	Yes	3	7	7
408	R:R:I135	R:R:M132	2.92	No	Yes	0	5	6
409	R:R:L136	R:R:M132	2.83	No	Yes	0	5	6
410	R:R:L133	R:R:P142	6.57	No	Yes	3	4	3
411	R:R:L133	R:R:L143	2.77	No	Yes	3	4	5
412	R:R:T134	R:R:Y139	3.75	No	Yes	0	5	3
413	R:R:T134	R:R:W141	4.85	No	Yes	3	5	7
414	R:R:P142	R:R:T134	3.5	Yes	No	3	3	5
415	R:R:I135	R:R:Y139	7.25	No	Yes	0	5	3
416	R:R:P142	R:R:Y137	12.52	Yes	No	0	3	4
417	R:R:N363	R:R:Y139	17.44	No	Yes	0	4	3
418	R:R:P142	R:R:W141	6.76	Yes	Yes	3	3	7
419	R:R:L143	R:R:W141	7.97	Yes	Yes	3	5	7
420	R:R:C148	R:R:W141	6.53	Yes	Yes	3	9	7
421	R:R:W141	R:R:W151	12.18	Yes	Yes	3	7	5
422	R:R:F222	R:R:W141	6.01	Yes	Yes	3	2	7
423	R:R:C227	R:R:W141	18.28	No	Yes	3	9	7
424	R:R:L143	R:R:P142	4.93	Yes	Yes	3	5	3
425	R:R:L147	R:R:P144	4.93	No	No	0	5	7
426	R:R:K146	R:R:L215	2.82	No	No	0	1	5
427	R:R:C148	R:R:V221	3.42	Yes	Yes	3	9	3
428	R:R:C148	R:R:F222	8.38	Yes	Yes	3	9	2
429	R:R:C148	R:R:C227	7.28	Yes	No	3	9	9
430	R:R:A149	R:R:V221	3.39	No	Yes	0	6	3
431	R:R:C227	R:R:W151	5.22	No	Yes	3	9	5
432	R:R:I152	R:R:V221	3.07	No	Yes	0	5	3
433	R:R:I152	R:R:L229	7.14	No	Yes	0	5	4
434	R:R:S207	R:R:Y153	5.09	No	No	0	7	6
435	R:R:I210	R:R:Y153	4.84	Yes	No	3	6	6
436	R:R:P211	R:R:Y153	6.95	No	No	3	5	6
437	R:R:D155	R:R:S159	4.42	Yes	No	3	8	7
438	R:R:D155	R:R:Y370	10.34	Yes	Yes	3	8	7
439	R:R:S207	R:R:V156	4.85	No	No	0	7	6
440	R:R:I210	R:R:V156	4.61	Yes	No	0	6	6
441	R:R:F158	R:R:L157	7.31	Yes	No	0	7	6
442	R:R:L157	R:R:S207	6.01	No	No	0	6	7
443	R:R:F158	R:R:W200	4.01	Yes	Yes	0	7	9
444	R:R:M164	R:R:T160	4.52	No	Yes	16	6	7
445	R:R:S203	R:R:T160	4.8	No	Yes	16	8	7
446	R:R:I206	R:R:T160	6.08	No	Yes	0	6	7
447	R:R:S242	R:R:T160	6.4	No	Yes	0	6	7
448	R:R:A161	R:R:W200	5.19	No	Yes	0	8	9
449	R:R:A161	R:R:S203	3.42	No	No	0	8	8
450	R:R:F332	R:R:S162	2.64	Yes	No	0	9	9
451	R:R:I163	R:R:P246	8.47	No	No	0	8	9
452	R:R:F332	R:R:I163	6.28	Yes	No	0	9	8
453	R:R:M164	R:R:S203	4.6	No	No	16	6	8
454	R:R:M164	R:R:P246	5.03	No	No	0	6	9
455	R:R:H165	R:R:V199	11.07	Yes	No	0	8	6
456	R:R:H165	R:R:W200	9.52	Yes	Yes	15	8	9
457	R:R:L166	R:R:M250	4.24	Yes	No	3	8	8
458	R:R:F329	R:R:L166	4.87	Yes	Yes	3	8	8
459	R:R:F332	R:R:L166	8.53	Yes	Yes	3	9	8
460	R:R:C167	R:R:I249	3.27	No	No	0	6	6
461	R:R:C167	R:R:M250	4.86	No	No	0	6	8
462	R:R:F329	R:R:I169	3.77	Yes	No	0	8	9
463	R:R:S170	R:R:T253	4.8	No	No	0	9	5
464	R:R:F329	R:R:S170	7.93	Yes	No	0	8	9
465	R:R:D172	R:R:K195	11.06	No	No	14	9	6
466	R:R:E318	R:R:R173	5.82	No	Yes	0	8	9
467	R:R:C322	R:R:R173	4.18	No	Yes	0	7	9
468	R:R:L325	R:R:R173	3.64	No	Yes	0	8	9
469	R:R:T253	R:R:Y174	4.99	No	Yes	0	5	8
470	R:R:L256	R:R:Y174	9.38	No	Yes	0	5	8
471	R:R:T257	R:R:Y174	3.75	No	Yes	0	9	8
472	R:R:I177	R:R:S260	9.29	No	No	0	9	6
473	R:R:I177	R:R:L261	4.28	No	No	17	9	8
474	R:R:E264	R:R:I177	8.2	No	No	17	7	9
475	R:R:N179	R:R:P180	4.89	No	No	0	6	8
476	R:R:K191	R:R:N187	2.8	No	No	0	6	6
477	R:R:R189	R:R:S188	2.64	No	No	0	4	7
478	R:R:F193	R:R:I197	8.79	No	No	0	4	2
479	R:R:I197	R:R:T201	3.04	No	No	0	2	4
480	R:R:T201	R:R:V204	3.17	No	No	0	4	4
481	R:R:I206	R:R:V241	4.61	No	No	0	6	4
482	R:R:F234	R:R:P209	4.33	Yes	No	0	7	7
483	R:R:I210	R:R:P211	3.39	Yes	No	3	6	5
484	R:R:I210	R:R:L229	2.85	Yes	Yes	3	6	4
485	R:R:F234	R:R:I210	8.79	Yes	Yes	3	7	6
486	R:R:F213	R:R:K220	8.69	No	No	3	4	3
487	R:R:D231	R:R:F213	11.94	No	No	3	5	4
488	R:R:F213	R:R:F234	4.29	No	Yes	3	4	7
489	R:R:D231	R:R:K220	8.3	No	No	3	5	3
490	R:R:F222	R:R:V221	2.62	Yes	Yes	3	2	3
491	R:R:K223	R:R:L228	5.64	No	No	0	3	4
492	R:R:A230	R:R:K223	6.42	No	No	0	3	3
493	R:R:L228	R:R:S226	4.5	No	No	0	4	4
494	R:R:F234	R:R:L229	4.87	Yes	Yes	3	7	4
495	R:R:L229	R:R:V235	5.96	Yes	No	0	4	6
496	R:R:D231	R:R:F234	4.78	No	Yes	3	5	7
497	R:R:D232	R:R:V347	4.38	No	No	0	4	5
498	R:R:N343	R:R:V235	5.91	Yes	No	0	7	6
499	R:R:V235	R:R:V347	4.81	No	No	0	6	5
500	R:R:I344	R:R:L236	5.71	Yes	No	0	5	6
501	R:R:G238	R:R:I237	3.53	No	No	0	6	4
502	R:R:F244	R:R:S239	2.64	No	No	0	5	6
503	R:R:N343	R:R:S239	4.47	Yes	No	0	7	6
504	R:R:I344	R:R:S239	4.64	Yes	No	0	5	6
505	R:R:F240	R:R:F244	7.5	No	No	0	4	5
506	R:R:F240	R:R:I344	5.02	No	Yes	0	4	5
507	R:R:F243	R:R:F244	10.72	Yes	No	0	8	5
508	R:R:F243	R:R:W336	3.01	Yes	Yes	3	8	8
509	R:R:C337	R:R:F243	5.59	No	Yes	0	6	8
510	R:R:F243	R:R:F340	23.58	Yes	Yes	3	8	7
511	R:R:I245	R:R:P246	5.08	No	No	0	5	9
512	R:R:F329	R:R:M250	8.71	Yes	No	3	8	8
513	R:R:F255	R:R:V251	2.62	No	No	0	1	5
514	R:R:I252	R:R:L256	2.85	No	No	0	5	5
515	R:R:F255	R:R:Y254	13.41	No	Yes	0	1	9
516	R:R:I258	R:R:Y254	10.88	No	Yes	0	5	9
517	R:R:G326	R:R:Y254	7.24	No	Yes	0	6	9
518	R:R:F329	R:R:Y254	7.22	Yes	Yes	0	8	9
519	R:R:K259	R:R:L256	2.82	No	No	0	4	5
520	R:R:I258	R:R:Q262	4.12	No	No	0	5	6
521	R:R:C322	R:R:I258	6.55	No	No	0	7	5
522	R:R:E264	R:R:L261	3.98	No	No	17	7	8
523	R:R:E318	R:R:L261	2.65	No	No	0	8	8
524	R:R:N317	R:R:Q313	2.64	No	No	0	6	5
525	R:R:K320	R:R:N317	5.6	No	No	0	8	6
526	R:R:K320	R:R:K323	5.75	No	No	0	8	7
527	R:R:V324	R:R:V379	4.81	Yes	No	0	8	8
528	R:R:V324	R:R:Y380	2.52	Yes	Yes	0	8	9
529	R:R:F383	R:R:V324	2.62	No	Yes	0	7	8
530	R:R:N384	R:R:V324	5.91	No	Yes	0	9	8
531	R:R:I327	R:R:V379	3.07	No	No	0	6	8
532	R:R:N376	R:R:V328	5.91	Yes	No	0	9	8
533	R:R:V328	R:R:V379	4.81	No	No	0	8	8
534	R:R:F330	R:R:V334	3.93	No	No	0	5	5
535	R:R:L331	R:R:V375	4.47	No	No	0	6	6
536	R:R:F332	R:R:W336	8.02	Yes	Yes	3	9	8
537	R:R:F332	R:R:S372	6.61	Yes	No	3	9	9
538	R:R:M335	R:R:S372	6.13	No	No	0	8	9
539	R:R:M335	R:R:V375	3.04	No	No	0	8	6
540	R:R:F339	R:R:W336	7.02	Yes	Yes	3	7	8
541	R:R:F340	R:R:W336	9.02	Yes	Yes	3	7	8
542	R:R:G369	R:R:W336	11.26	No	Yes	0	7	8
543	R:R:S372	R:R:W336	6.18	No	Yes	3	9	8
544	R:R:C337	R:R:I341	3.27	No	No	0	6	6
545	R:R:F365	R:R:P338	7.22	Yes	No	0	5	9
546	R:R:F339	R:R:F340	7.5	Yes	Yes	3	7	7
547	R:R:F339	R:R:N343	4.83	Yes	Yes	3	7	7
548	R:R:F339	R:R:L362	4.87	Yes	Yes	3	7	3
549	R:R:F339	R:R:V366	9.18	Yes	No	0	7	6
550	R:R:L362	R:R:T342	5.9	Yes	No	0	3	5
551	R:R:F365	R:R:T342	3.89	Yes	No	0	5	5
552	R:R:L362	R:R:N343	5.49	Yes	Yes	3	3	7
553	R:R:I344	R:R:I348	2.94	Yes	No	0	5	4
554	R:R:I348	R:R:M345	4.37	No	No	0	4	4
555	R:R:A346	R:R:I358	3.25	No	Yes	0	4	4
556	R:R:C349	R:R:S352	3.44	No	No	0	3	2
557	R:R:C349	R:R:C353	7.28	No	No	0	3	3
558	R:R:E351	R:R:K350	2.7	No	No	0	5	1
559	R:R:E351	R:R:S352	4.31	No	No	0	5	2
560	R:R:C353	R:R:I358	6.55	No	Yes	0	3	4
561	R:R:D356	R:R:N354	2.69	No	No	0	2	1
562	R:R:N354	R:R:V357	4.43	No	No	0	1	5
563	R:R:E355	R:R:I358	4.1	No	Yes	0	3	4
564	R:R:L361	R:R:V357	2.98	No	No	0	4	5
565	R:R:F365	R:R:L361	6.09	Yes	No	0	5	4
566	R:R:F365	R:R:V364	2.62	Yes	No	0	5	4
567	R:R:F365	R:R:I368	3.77	Yes	No	0	5	7
568	R:R:V366	R:R:Y370	7.57	No	Yes	0	6	7
569	R:R:W367	R:R:Y370	20.26	Yes	Yes	3	6	7
570	R:R:N376	R:R:P377	3.26	Yes	No	0	9	9
571	R:R:N376	R:R:Y380	5.81	Yes	Yes	0	9	9
572	R:R:Y380	R:R:Y387	11.91	Yes	Yes	5	9	8
573	R:R:L382	R:R:T381	2.95	No	No	0	5	7
574	R:R:F391	R:R:T381	2.59	Yes	No	0	6	7
575	R:R:F383	R:R:L382	6.09	No	No	0	7	5
576	R:R:N384	R:R:Y387	5.81	No	Yes	0	9	8
577	R:R:T386	R:R:Y387	3.75	No	Yes	5	6	8
578	R:R:F391	R:R:Y387	7.22	Yes	Yes	5	6	8
579	R:R:R393	R:R:S389	7.91	Yes	No	0	4	4
580	R:R:A390	R:R:R393	2.77	No	Yes	0	7	4
581	R:R:A390	R:R:Y394	6.67	No	Yes	0	7	4
582	R:R:S392	S:S:T190	4.8	No	No	0	3	5
583	R:R:Q398	R:R:R393	9.35	No	Yes	0	4	4
584	R:R:I395	R:R:Q396	5.49	No	No	0	6	4
585	R:R:Q396	R:R:Q398	5.12	No	No	0	4	4
586	R:R:Q396	S:S:T190	7.09	No	No	0	4	5
587	S:S:H70	S:S:L71	2.57	No	No	0	3	3
588	S:S:N75	S:S:Q72	5.28	Yes	No	11	5	1
589	S:S:Q72	S:S:W76	3.29	No	No	11	1	4
590	S:S:N75	S:S:W76	9.04	Yes	No	11	5	4
591	S:S:M132	S:S:T81	7.53	Yes	No	0	6	6
592	S:S:T81	S:S:W367	15.77	No	Yes	0	6	6
593	S:S:L87	S:S:V83	2.98	No	No	0	4	4
594	S:S:M128	S:S:V84	3.04	Yes	No	0	8	7
595	S:S:V84	S:S:W367	4.9	No	Yes	0	7	6
596	S:S:I85	S:S:I89	2.94	Yes	No	0	6	5
597	S:S:I85	S:S:M128	2.92	Yes	Yes	0	6	8
598	S:S:I85	S:S:P129	5.08	Yes	No	0	6	8
599	S:S:I85	S:S:M132	4.37	Yes	Yes	0	6	6
600	S:S:I85	S:S:W367	3.52	Yes	Yes	0	6	6
601	S:S:N92	S:S:T88	4.39	Yes	Yes	0	9	7
602	S:S:M128	S:S:T88	3.01	Yes	Yes	2	8	7
603	S:S:S373	S:S:T88	3.2	No	Yes	2	9	7
604	S:S:A374	S:S:T88	3.36	No	Yes	0	6	7
605	S:S:F125	S:S:I89	5.02	No	No	0	4	5
606	S:S:G91	S:S:P377	4.06	No	No	0	8	9
607	S:S:A117	S:S:N92	4.69	No	Yes	0	9	9
608	S:S:D120	S:S:N92	8.08	Yes	Yes	0	9	9
609	S:S:N92	S:S:P377	9.77	Yes	No	0	9	9
610	S:S:I93	S:S:I96	2.94	No	No	0	3	6
611	S:S:F391	S:S:L94	13.4	Yes	No	0	6	6
612	S:S:I395	S:S:L94	2.85	No	No	0	6	6
613	S:S:A117	S:S:V95	3.39	No	Yes	0	9	9
614	S:S:P377	S:S:V95	3.53	No	Yes	0	9	9
615	S:S:V95	S:S:Y380	7.57	Yes	Yes	4	9	9
616	S:S:V95	S:S:Y387	2.52	Yes	Yes	4	9	8
617	S:S:F391	S:S:V95	2.62	Yes	Yes	4	6	9
618	S:S:I118	S:S:I96	5.89	No	No	0	6	6
619	S:S:M97	S:S:Y394	11.97	No	No	0	4	4
620	S:S:V99	S:S:Y111	2.52	No	No	0	7	4
621	S:S:M114	S:S:V99	7.61	No	No	0	5	7
622	S:S:V99	S:S:Y387	3.79	No	Yes	0	7	8
623	S:S:L101	S:S:S100	3	No	No	0	5	1
624	S:S:L101	S:S:Y394	8.21	No	No	18	5	4
625	S:S:L101	S:S:Y399	26.96	No	No	18	5	2
626	S:S:E102	S:S:K103	2.7	No	No	0	6	6
627	S:S:E102	S:S:K104	6.75	No	No	0	6	6
628	S:S:K104	S:S:L105	15.51	No	Yes	4	6	8
629	S:S:K104	S:S:T386	10.51	No	Yes	4	6	6
630	S:S:L105	S:S:N110	9.61	Yes	Yes	4	8	9
631	S:S:L105	S:S:N384	4.12	Yes	No	4	8	9
632	S:S:L105	S:S:T386	5.9	Yes	Yes	4	8	6
633	S:S:L105	S:S:Y387	12.89	Yes	Yes	4	8	8
634	S:S:Q106	S:S:Y111	12.4	No	No	0	7	4
635	S:S:Q106	S:S:R189	3.5	No	No	0	7	4
636	S:S:N107	S:S:N110	10.9	No	Yes	0	7	9
637	S:S:N110	S:S:T109	2.92	Yes	No	0	9	8
638	S:S:N110	S:S:Y387	5.81	Yes	Yes	4	9	8
639	S:S:A168	S:S:F112	2.77	No	Yes	0	7	8
640	S:S:F112	S:S:I169	12.56	Yes	No	0	8	9
641	S:S:D172	S:S:F112	7.17	No	Yes	19	9	8
642	S:S:F112	S:S:K195	6.2	Yes	No	19	8	6
643	S:S:F112	S:S:I196	6.28	Yes	No	0	8	8
644	S:S:L113	S:S:Y380	11.72	No	Yes	0	8	9
645	S:S:H165	S:S:S115	9.76	No	No	0	8	9
646	S:S:I196	S:S:S115	4.64	No	No	0	8	9
647	S:S:D120	S:S:L116	5.43	Yes	No	2	9	9
648	S:S:L116	S:S:S162	3	No	No	2	9	9
649	S:S:H165	S:S:L116	5.14	No	No	0	8	9
650	S:S:I118	S:S:M121	2.92	No	No	0	6	7
651	S:S:I118	S:S:W200	4.7	No	Yes	0	6	9
652	S:S:A119	S:S:W200	2.59	No	Yes	0	8	9
653	S:S:D120	S:S:S162	4.42	Yes	No	2	9	9
654	S:S:D120	S:S:S373	11.78	Yes	No	2	9	9
655	S:S:F158	S:S:L122	12.18	Yes	No	0	7	7
656	S:S:L123	S:S:V127	4.47	No	Yes	0	7	8
657	S:S:L123	S:S:M128	2.83	No	Yes	0	7	8
658	S:S:F158	S:S:L123	7.31	Yes	No	0	7	7
659	S:S:G124	S:S:M128	5.24	No	Yes	0	6	8
660	S:S:F125	S:S:L126	3.65	No	No	0	4	5
661	S:S:L126	S:S:L154	2.77	No	No	0	5	5
662	S:S:V127	S:S:W151	3.68	Yes	Yes	2	8	5
663	S:S:D155	S:S:V127	5.84	Yes	Yes	2	8	8
664	S:S:V127	S:S:Y370	3.79	Yes	Yes	2	8	7
665	S:S:M128	S:S:Y370	13.17	Yes	Yes	2	8	7
666	S:S:M128	S:S:S373	3.07	Yes	No	2	8	9
667	S:S:L143	S:S:V130	2.98	No	No	0	5	4
668	S:S:V130	S:S:W151	14.71	No	Yes	0	4	5
669	S:S:S131	S:S:W367	9.88	No	Yes	2	7	6
670	S:S:S131	S:S:Y370	2.54	No	Yes	2	7	7
671	S:S:L136	S:S:M132	5.65	No	Yes	0	5	6
672	S:S:L133	S:S:Y137	3.52	No	No	2	4	4
673	S:S:L133	S:S:P142	4.93	No	No	2	4	3
674	S:S:T134	S:S:Y139	4.99	No	Yes	0	5	3
675	S:S:I135	S:S:Y139	13.3	No	Yes	0	5	3
676	S:S:I135	S:S:W367	3.52	No	Yes	0	5	6
677	S:S:P142	S:S:Y137	9.74	No	No	2	3	4
678	S:S:N363	S:S:Y139	16.28	No	Yes	0	4	3
679	S:S:G225	S:S:R140	4.5	No	No	0	3	4
680	S:S:P142	S:S:W141	5.4	No	Yes	2	3	7
681	S:S:L143	S:S:W141	10.25	No	Yes	0	5	7
682	S:S:C148	S:S:W141	6.53	Yes	Yes	2	9	7
683	S:S:W141	S:S:W151	10.31	Yes	Yes	2	7	5
684	S:S:F222	S:S:W141	5.01	Yes	Yes	2	2	7
685	S:S:C227	S:S:W141	15.67	Yes	Yes	2	9	7
686	S:S:L143	S:S:P144	4.93	No	No	0	5	7
687	S:S:L147	S:S:P144	4.93	No	No	0	5	7
688	S:S:F222	S:S:S145	3.96	Yes	No	0	2	3
689	S:S:C148	S:S:V221	5.12	Yes	Yes	0	9	3
690	S:S:C148	S:S:F222	11.17	Yes	Yes	2	9	2
691	S:S:C148	S:S:C227	7.28	Yes	Yes	2	9	9
692	S:S:A149	S:S:V221	5.09	No	Yes	0	6	3
693	S:S:C227	S:S:W151	2.61	Yes	Yes	2	9	5
694	S:S:I152	S:S:I210	4.42	No	Yes	0	5	6
695	S:S:I152	S:S:V221	3.07	No	Yes	0	5	3
696	S:S:I152	S:S:L229	7.14	No	Yes	0	5	4
697	S:S:L154	S:S:Y153	3.52	No	Yes	0	5	6
698	S:S:S207	S:S:Y153	6.36	No	Yes	0	7	6
699	S:S:I210	S:S:Y153	3.63	Yes	Yes	2	6	6
700	S:S:P211	S:S:Y153	4.17	No	Yes	2	5	6
701	S:S:D155	S:S:V156	4.38	Yes	Yes	2	8	6
702	S:S:D155	S:S:S159	4.42	Yes	No	2	8	7
703	S:S:D155	S:S:Y370	4.6	Yes	Yes	2	8	7
704	S:S:S207	S:S:V156	4.85	No	Yes	0	7	6
705	S:S:I210	S:S:V156	4.61	Yes	Yes	2	6	6
706	S:S:F158	S:S:L157	7.31	Yes	No	0	7	6
707	S:S:L157	S:S:V204	5.96	No	No	0	6	4
708	S:S:L157	S:S:S207	9.01	No	No	0	6	7
709	S:S:F158	S:S:W200	4.01	Yes	Yes	0	7	9
710	S:S:S203	S:S:T160	6.4	No	No	0	8	7
711	S:S:S242	S:S:T160	7.99	No	No	0	6	7
712	S:S:A161	S:S:W200	3.89	No	Yes	0	8	9
713	S:S:A161	S:S:S203	3.42	No	No	0	8	8
714	S:S:F332	S:S:S162	2.64	Yes	No	2	9	9
715	S:S:I163	S:S:L166	2.85	Yes	Yes	2	8	8
716	S:S:I163	S:S:P246	5.08	Yes	Yes	0	8	9
717	S:S:I163	S:S:M250	2.92	Yes	Yes	2	8	8
718	S:S:F332	S:S:I163	7.54	Yes	Yes	2	9	8
719	S:S:M164	S:S:S203	3.07	No	No	0	6	8
720	S:S:M164	S:S:P246	6.71	No	Yes	0	6	9
721	S:S:H165	S:S:V199	2.77	No	No	0	8	6
722	S:S:L166	S:S:M250	4.24	Yes	Yes	2	8	8
723	S:S:L166	S:S:V328	2.98	Yes	Yes	2	8	8
724	S:S:F329	S:S:L166	7.31	Yes	Yes	2	8	8
725	S:S:F332	S:S:L166	8.53	Yes	Yes	2	9	8
726	S:S:C167	S:S:I249	6.55	No	No	0	6	6
727	S:S:S170	S:S:T253	4.8	No	No	0	9	5
728	S:S:F329	S:S:S170	2.64	Yes	No	0	8	9
729	S:S:D172	S:S:V175	4.38	No	No	0	9	5
730	S:S:D172	S:S:K195	8.3	No	No	19	9	6
731	S:S:I177	S:S:R173	3.76	Yes	Yes	6	9	9
732	S:S:R173	S:S:T257	11.64	Yes	No	6	9	9
733	S:S:L261	S:S:R173	3.64	No	Yes	0	8	9
734	S:S:I177	S:S:Y174	4.84	Yes	No	6	9	8
735	S:S:L256	S:S:Y174	3.52	No	No	0	5	8
736	S:S:T257	S:S:Y174	8.74	No	No	6	9	8
737	S:S:I177	S:S:T257	4.56	Yes	No	6	9	9
738	S:S:E264	S:S:I177	4.1	No	Yes	0	7	9
739	S:S:K191	S:S:N187	9.79	No	No	0	6	6
740	S:S:F193	S:S:I197	5.02	No	No	0	4	2
741	S:S:K195	S:S:V199	4.55	No	No	0	6	6
742	S:S:I202	S:S:I206	2.94	No	No	0	5	6
743	S:S:I206	S:S:V241	3.07	No	No	0	6	4
744	S:S:I210	S:S:P211	3.39	Yes	No	2	6	5
745	S:S:F234	S:S:I210	7.54	Yes	Yes	0	7	6
746	S:S:D231	S:S:F213	5.97	No	No	0	5	4
747	S:S:G214	S:S:V221	3.68	No	Yes	0	7	3
748	S:S:C227	S:S:F222	4.19	Yes	Yes	2	9	2
749	S:S:K223	S:S:L228	5.64	No	No	0	3	4
750	S:S:A230	S:S:K223	3.21	No	No	0	3	3
751	S:S:E355	S:S:K223	2.7	No	No	0	3	3
752	S:S:L228	S:S:S226	4.5	No	No	0	4	4
753	S:S:F234	S:S:L229	6.09	Yes	Yes	0	7	4
754	S:S:L229	S:S:V235	2.98	Yes	No	0	4	6
755	S:S:D232	S:S:N233	2.69	No	No	0	4	3
756	S:S:D232	S:S:V347	4.38	No	Yes	0	4	5
757	S:S:F234	S:S:G238	4.52	Yes	No	0	7	6
758	S:S:N343	S:S:V235	5.91	Yes	No	0	7	6
759	S:S:V235	S:S:V347	4.81	No	Yes	0	6	5
760	S:S:I344	S:S:L236	2.85	No	No	0	5	6
761	S:S:L236	S:S:V347	4.47	No	Yes	0	6	5
762	S:S:G238	S:S:I237	3.53	No	No	0	6	4
763	S:S:F340	S:S:S239	7.93	Yes	Yes	2	7	6
764	S:S:N343	S:S:S239	2.98	Yes	Yes	2	7	6
765	S:S:I344	S:S:S239	3.1	No	Yes	0	5	6
766	S:S:F240	S:S:F244	10.72	No	No	0	4	5
767	S:S:F240	S:S:I344	5.02	No	No	0	4	5
768	S:S:F243	S:S:F244	12.86	Yes	No	0	8	5
769	S:S:A247	S:S:F243	5.55	No	Yes	0	6	8
770	S:S:F243	S:S:V333	2.62	Yes	No	0	8	6
771	S:S:F243	S:S:W336	3.01	Yes	Yes	2	8	8
772	S:S:F243	S:S:F340	21.43	Yes	Yes	2	8	7
773	S:S:F244	S:S:I341	5.02	No	No	0	5	6
774	S:S:I245	S:S:P246	3.39	No	Yes	0	5	9
775	S:S:M250	S:S:V333	3.04	Yes	No	0	8	6
776	S:S:I252	S:S:T253	4.56	No	No	0	5	5
777	S:S:I252	S:S:L256	5.71	No	No	0	5	5
778	S:S:F255	S:S:Y254	8.25	No	Yes	0	1	9
779	S:S:I258	S:S:Y254	9.67	No	Yes	0	5	9
780	S:S:G326	S:S:Y254	7.24	No	Yes	2	6	9
781	S:S:F329	S:S:Y254	6.19	Yes	Yes	2	8	9
782	S:S:C322	S:S:I258	6.55	No	No	0	7	5
783	S:S:K259	S:S:Q262	4.07	No	No	0	4	6
784	S:S:K259	S:S:K263	2.87	No	No	0	4	5
785	S:S:E264	S:S:L261	3.98	No	No	0	7	8
786	S:S:E318	S:S:L261	3.98	No	No	0	8	8
787	S:S:I315	S:S:M312	7.29	Yes	No	0	5	4
788	S:S:E318	S:S:S314	2.87	No	No	0	8	5
789	S:S:K320	S:S:S316	4.59	No	No	0	8	6
790	S:S:I327	S:S:K323	2.91	No	No	0	6	7
791	S:S:F383	S:S:K323	8.69	No	No	0	7	7
792	S:S:L325	S:S:V324	2.98	No	No	0	8	8
793	S:S:F329	S:S:L325	6.09	Yes	No	0	8	8
794	S:S:F329	S:S:G326	4.52	Yes	No	2	8	6
795	S:S:I327	S:S:V379	3.07	No	Yes	0	6	8
796	S:S:F329	S:S:V328	2.62	Yes	Yes	2	8	8
797	S:S:N376	S:S:V328	7.39	No	Yes	0	9	8
798	S:S:F330	S:S:L331	4.87	No	No	0	5	6
799	S:S:F330	S:S:V334	11.8	No	No	0	5	5
800	S:S:L331	S:S:V375	5.96	No	Yes	0	6	6
801	S:S:F332	S:S:W336	7.02	Yes	Yes	2	9	8
802	S:S:F332	S:S:S372	3.96	Yes	No	2	9	9
803	S:S:I368	S:S:M335	2.92	No	No	0	7	8
804	S:S:M335	S:S:S372	3.07	No	No	0	8	9
805	S:S:M335	S:S:V375	3.04	No	Yes	0	8	6
806	S:S:F339	S:S:W336	7.02	Yes	Yes	2	7	8
807	S:S:F340	S:S:W336	9.02	Yes	Yes	2	7	8
808	S:S:G369	S:S:W336	12.67	No	Yes	0	7	8
809	S:S:W336	S:S:Y370	3.86	Yes	Yes	2	8	7
810	S:S:S372	S:S:W336	4.94	No	Yes	2	9	8
811	S:S:F365	S:S:P338	10.11	Yes	No	0	5	9
812	S:S:F339	S:S:F340	12.86	Yes	Yes	2	7	7
813	S:S:F339	S:S:N343	13.29	Yes	Yes	2	7	7
814	S:S:F339	S:S:L362	3.65	Yes	No	2	7	3
815	S:S:F339	S:S:V366	6.55	Yes	Yes	2	7	6
816	S:S:L362	S:S:T342	2.95	No	No	0	3	5
817	S:S:F365	S:S:T342	3.89	Yes	No	0	5	5
818	S:S:L362	S:S:N343	4.12	No	Yes	2	3	7
819	S:S:I348	S:S:M345	4.37	No	No	0	4	4
820	S:S:C349	S:S:I348	3.27	No	No	0	3	4
821	S:S:C349	S:S:C353	7.28	No	No	0	3	3
822	S:S:D356	S:S:N354	4.04	No	No	0	2	1
823	S:S:N354	S:S:V357	5.91	No	No	0	1	5
824	S:S:E355	S:S:G359	4.91	No	No	0	3	2
825	S:S:L361	S:S:V357	2.98	No	No	0	4	5
826	S:S:F365	S:S:L361	9.74	Yes	No	0	5	4
827	S:S:F365	S:S:V364	3.93	Yes	No	0	5	4
828	S:S:F365	S:S:I368	3.77	Yes	No	0	5	7
829	S:S:V366	S:S:W367	3.68	Yes	Yes	2	6	6
830	S:S:V366	S:S:Y370	8.83	Yes	Yes	2	6	7
831	S:S:W367	S:S:Y370	12.54	Yes	Yes	2	6	7
832	S:S:N376	S:S:V375	2.96	No	Yes	0	9	6
833	S:S:N376	S:S:Y380	4.65	No	Yes	0	9	9
834	S:S:L378	S:S:L382	4.15	No	No	0	6	5
835	S:S:Y380	S:S:Y387	17.87	Yes	Yes	4	9	8
836	S:S:R388	S:S:T381	5.17	No	No	0	9	7
837	S:S:F391	S:S:T381	10.38	Yes	No	0	6	7
838	S:S:F383	S:S:L382	9.74	No	No	0	7	5
839	S:S:N384	S:S:T386	2.92	No	Yes	4	9	6
840	S:S:N384	S:S:Y387	9.3	No	Yes	4	9	8
841	S:S:K385	S:S:T386	4.5	No	Yes	0	5	6
842	S:S:F391	S:S:Y387	4.13	Yes	Yes	4	6	8
843	S:S:Q398	S:S:R393	4.67	No	No	0	4	4
844	S:S:Y394	S:S:Y399	8.94	No	No	18	4	2
845	P:P:F125	P:P:I89	2.51	No	No	0	4	5
846	P:P:F244	P:P:I341	2.51	No	No	0	5	6
847	P:P:F255	P:P:I258	2.51	No	No	0	1	5
848	P:P:T253	P:P:Y174	2.5	No	No	0	5	8
849	P:P:K400	P:P:R393	2.48	No	Yes	0	3	4
850	R:R:K385	R:R:R388	2.48	No	No	0	5	9
851	P:P:F213	S:S:L71	2.44	No	No	0	4	3
852	R:R:F330	R:R:L331	2.44	No	No	0	5	6
853	S:S:F193	S:S:L194	2.44	No	No	0	4	3
854	S:S:D231	S:S:F234	2.39	No	Yes	0	5	7
855	P:P:N75	P:P:W76	2.26	No	No	0	5	4
856	R:R:Q106	R:R:Y111	2.25	No	No	0	7	4
857	M:M:?1	S:S:L228	2.16	Yes	No	0	0	4
858	S:S:R393	S:S:Y399	2.06	No	No	0	4	2
859	P:P:A90	P:P:G91	1.95	No	No	0	4	8
860	R:R:A90	R:R:G91	1.95	No	No	0	4	8
861	R:R:A149	R:R:G214	1.95	No	No	0	6	7
862	S:S:A90	S:S:G91	1.95	No	No	0	4	8
863	S:S:C167	S:S:P246	1.88	No	Yes	0	6	9
864	S:S:C337	S:S:P338	1.88	No	No	0	6	9
865	R:R:G238	R:R:S242	1.86	No	No	0	6	6
866	R:R:G205	R:R:V204	1.84	No	No	0	4	4
867	R:R:A108	R:R:A192	1.79	No	No	0	5	7
868	S:S:A390	S:S:A98	1.79	No	No	0	7	7
869	S:S:A108	S:S:A192	1.79	No	No	0	5	7
870	P:P:G205	P:P:I206	1.76	No	No	0	4	6
871	R:R:G359	R:R:I358	1.76	No	Yes	0	2	4
872	S:S:G359	S:S:I358	1.76	No	No	0	2	4
873	R:R:G205	R:R:M208	1.75	No	No	0	4	4
874	S:S:C353	S:S:S352	1.72	No	No	0	3	2
875	P:P:A108	P:P:S188	1.71	No	No	0	5	7
876	P:P:G205	S:S:L79	1.71	No	No	0	4	4
877	P:P:G359	P:P:L362	1.71	No	Yes	0	2	3
878	R:R:G359	R:R:L362	1.71	No	Yes	0	2	3
879	P:P:A168	P:P:V199	1.7	No	No	0	7	6
880	P:P:G205	S:S:N75	1.7	No	Yes	0	4	5
881	R:R:A247	R:R:V333	1.7	No	No	0	6	6
882	S:S:A371	S:S:V84	1.7	No	No	0	4	7
883	S:S:A346	S:S:V347	1.7	No	Yes	0	4	5
884	R:R:A198	R:R:T201	1.68	No	No	0	2	4
885	R:R:M208	R:R:P209	1.68	No	No	0	4	7
886	S:S:M208	S:S:P209	1.68	No	No	0	4	7
887	S:S:M208	S:S:P211	1.68	No	No	0	4	5
888	P:P:K146	P:P:P144	1.67	No	No	0	1	7
889	P:P:C349	P:P:I348	1.64	No	No	0	3	4
890	R:R:L143	R:R:P144	1.64	Yes	No	0	5	7
891	S:S:C353	S:S:I358	1.64	No	No	0	3	4
892	P:P:A247	P:P:I163	1.62	No	Yes	0	6	8
893	P:P:A346	P:P:I358	1.62	No	No	0	4	4
894	R:R:A247	R:R:I163	1.62	No	No	0	6	8
895	R:R:A265	R:R:I315	1.62	No	No	0	5	5
896	S:S:S219	S:S:V221	1.62	No	Yes	0	3	3
897	S:S:S242	S:S:V241	1.62	No	No	0	6	4
898	P:P:A82	P:P:M132	1.61	No	No	0	3	6
899	S:S:A82	S:S:M132	1.61	No	Yes	0	3	6
900	S:S:V324	S:S:V379	1.6	No	Yes	0	8	8
901	S:S:V328	S:S:V379	1.6	Yes	Yes	0	8	8
902	S:S:V375	S:S:V379	1.6	Yes	Yes	0	6	8
903	P:P:A78	P:P:L136	1.58	No	No	0	6	5
904	P:P:A374	P:P:L87	1.58	No	No	0	6	4
905	R:R:A374	R:R:L87	1.58	No	No	0	6	4
906	S:S:A374	S:S:L87	1.58	No	No	0	6	4
907	R:R:A108	R:R:N107	1.56	No	No	0	5	7
908	P:P:I135	P:P:S77	1.55	No	No	0	5	3
909	S:S:I177	S:S:S260	1.55	Yes	No	0	9	6
910	S:S:I315	S:S:S316	1.55	Yes	No	0	5	6
911	P:P:M114	P:P:S100	1.53	No	No	0	5	1
912	R:R:K220	R:R:S219	1.53	No	No	0	3	3
913	P:P:I202	P:P:T201	1.52	No	No	0	5	4
914	P:P:I252	P:P:T248	1.52	No	No	0	5	3
915	R:R:I252	R:R:T248	1.52	No	No	0	5	3
916	R:R:A265	R:R:Q319	1.52	No	No	0	5	5
917	S:S:I202	S:S:T201	1.52	No	No	0	5	4
918	S:S:M250	S:S:V251	1.52	Yes	No	0	8	5
919	S:S:I315	S:S:T311	1.52	Yes	No	0	5	4
920	R:R:F222	R:R:G225	1.51	Yes	No	0	2	3
921	R:R:M312	R:R:T311	1.51	No	No	0	4	4
922	R:R:K104	R:R:T386	1.5	No	No	0	6	6
923	R:R:L215	R:R:S219	1.5	No	No	0	5	3
924	S:S:K191	S:S:T190	1.5	No	No	0	6	5
925	P:P:L80	P:P:V84	1.49	No	No	0	4	7
926	P:P:L154	P:P:V127	1.49	No	Yes	0	5	8
927	R:R:L79	S:S:V204	1.49	No	No	0	4	4
928	R:R:N179	R:R:V175	1.48	No	No	0	6	5
929	P:P:I85	P:P:I86	1.47	No	No	0	6	4
930	P:P:I93	P:P:I96	1.47	No	No	0	3	6
931	P:P:I202	P:P:I206	1.47	No	No	0	5	6
932	R:R:I202	R:R:I206	1.47	No	No	0	5	6
933	S:S:I196	S:S:I197	1.47	No	No	0	8	2
934	P:P:I315	P:P:M312	1.46	No	No	0	5	4
935	R:R:N187	R:R:T190	1.46	No	No	0	6	5
936	R:R:G138	R:R:Y139	1.45	No	Yes	0	5	3
937	S:S:G138	S:S:Y139	1.45	No	Yes	0	5	3
938	P:P:E318	P:P:S314	1.44	No	No	0	8	5
939	R:R:Q313	R:R:S314	1.44	No	No	0	5	5
940	S:S:Q313	S:S:S314	1.44	No	No	0	5	5
941	P:P:I395	P:P:L94	1.43	No	No	0	6	6
942	P:P:L194	S:S:I395	1.43	No	No	0	3	6
943	R:R:I237	R:R:N233	1.42	No	No	0	4	3
944	R:R:W76	S:S:G205	1.41	No	No	0	4	4
945	R:R:K191	R:R:L194	1.41	No	No	0	6	3
946	S:S:K146	S:S:L147	1.41	No	No	0	1	5
947	S:S:K320	S:S:N317	1.4	No	No	0	8	6
948	S:S:A98	S:S:F391	1.39	No	Yes	0	7	6
949	P:P:L378	P:P:L382	1.38	No	No	0	6	5
950	R:R:A321	R:R:R173	1.38	No	Yes	0	8	9
951	S:S:A176	S:S:R173	1.38	No	Yes	0	8	9
952	S:S:D231	S:S:K220	1.38	No	No	0	5	3
953	S:S:E318	S:S:I315	1.37	No	Yes	0	8	5
954	P:P:K103	P:P:Q106	1.36	No	No	0	6	7
955	R:R:K74	R:R:Q72	1.36	No	No	0	6	1
956	P:P:E264	P:P:K263	1.35	No	No	0	7	5
957	R:R:E355	R:R:K223	1.35	No	No	0	3	3
958	R:R:F222	R:R:S145	1.32	Yes	No	0	2	3
959	R:R:R185	R:R:S188	1.32	No	No	0	4	7
960	S:S:N179	S:S:Q178	1.32	No	No	0	6	6
961	P:P:H70	P:P:L69	1.29	No	No	0	3	7
962	R:R:Q262	R:R:Q319	1.28	No	No	0	6	5
963	R:R:I181	R:R:R185	1.25	No	No	0	7	4
964	R:R:F383	R:R:K323	1.24	No	No	0	7	7
965	R:R:F186	R:R:N187	1.21	No	No	0	4	6
966	P:P:K400	P:P:Y399	1.19	No	No	0	3	2
967	R:R:N75	R:R:W76	1.13	No	No	0	5	4
968	R:R:Q178	R:R:Y174	1.13	No	Yes	0	6	8
969	R:R:E73	R:R:W76	1.09	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.34	12	3	0
2	M:M:?1	8.10929	14	2	0
3	P:P:T88	3.852	5	1	7
4	P:P:V95	3.9875	4	0	9
5	P:P:L105	6.95	4	1	8
6	P:P:Y111	6.836	5	8	4
7	P:P:L116	5.375	4	1	9
8	P:P:D120	5.864	5	1	9
9	P:P:V127	5.456	5	1	8
10	P:P:M128	5.09286	7	1	8
11	P:P:W141	10.1	6	1	7
12	P:P:P142	5.82	5	1	3
13	P:P:L143	7.285	4	1	5
14	P:P:C148	7.0325	4	1	9
15	P:P:W151	7.02833	6	1	5
16	P:P:D155	8.545	4	1	8
17	P:P:L157	5.375	4	1	6
18	P:P:F158	5.008	5	1	7
19	P:P:I163	4.6025	4	0	8
20	P:P:H165	7.388	5	1	8
21	P:P:L166	5.85	4	1	8
22	P:P:R173	4.942	5	0	9
23	P:P:R189	9.385	4	8	4
24	P:P:W200	5.51	5	1	9
25	P:P:I210	4.7275	4	10	6
26	P:P:D217	5.605	4	12	6
27	P:P:K220	6.0275	4	12	3
28	P:P:C227	6.88	4	1	9
29	P:P:L229	5.084	5	0	4
30	P:P:F234	6.79	4	10	7
31	P:P:F243	7.772	5	1	8
32	P:P:M250	5.1725	4	1	8
33	P:P:F329	6.23	4	1	8
34	P:P:F332	5.19667	6	1	9
35	P:P:W336	6.14889	9	1	8
36	P:P:F339	8.58833	6	1	7
37	P:P:F340	9.585	6	1	7
38	P:P:N343	5.562	5	1	7
39	P:P:L362	4.684	5	1	3
40	P:P:F365	6.6125	4	0	5
41	P:P:W367	10.225	4	1	6
42	P:P:Y370	7.86125	8	1	7
43	P:P:N376	5.605	4	1	9
44	P:P:Y380	5.19167	6	1	9
45	P:P:Y387	6.87	7	1	8
46	P:P:F391	6.445	4	0	6
47	P:P:R393	3.6975	4	0	4
48	P:P:Y394	6.2125	4	7	4
49	R:R:N92	5.975	4	13	9
50	R:R:L94	5.43	4	0	6
51	R:R:V95	3.694	5	5	9
52	R:R:I96	4.0025	4	13	6
53	R:R:F112	4.774	5	14	8
54	R:R:L123	5.214	5	3	7
55	R:R:V127	5.478	5	3	8
56	R:R:M128	5.63667	6	3	8
57	R:R:M132	5.2525	4	0	6
58	R:R:Y139	7.4725	4	0	3
59	R:R:W141	8.2825	8	3	7
60	R:R:P142	6.856	5	3	3
61	R:R:L143	4.3275	4	3	5
62	R:R:C148	6.4025	4	3	9
63	R:R:W151	8.94	6	3	5
64	R:R:D155	8.64	5	3	8
65	R:R:F158	7.38	5	0	7
66	R:R:T160	5.45	4	16	7
67	R:R:H165	8.8475	4	15	8
68	R:R:L166	5.1025	4	3	8
69	R:R:R173	4.038	5	0	9
70	R:R:Y174	4.8125	4	0	8
71	R:R:W200	5.51	5	15	9
72	R:R:I210	4.896	5	3	6
73	R:R:V221	3.125	4	3	3
74	R:R:F222	3.968	5	3	2
75	R:R:L229	5.462	5	3	4
76	R:R:F234	4.98667	6	3	7
77	R:R:F243	10.725	4	3	8
78	R:R:Y254	9.6875	4	0	9
79	R:R:V324	3.965	4	0	8
80	R:R:F329	6.5	5	3	8
81	R:R:F332	6.416	5	3	9
82	R:R:W336	6.74	7	3	8
83	R:R:F339	9.05833	6	3	7
84	R:R:F340	12.6425	4	3	7
85	R:R:N343	4.784	5	3	7
86	R:R:I344	4.5775	4	0	5
87	R:R:I358	3.915	4	0	4
88	R:R:L362	4.4925	4	3	3
89	R:R:F365	4.718	5	0	5
90	R:R:W367	9.384	5	3	6
91	R:R:Y370	8.77	8	3	7
92	R:R:N376	4.4175	4	0	9
93	R:R:Y380	7.15	5	5	9
94	R:R:Y387	6.00222	9	5	8
95	R:R:F391	5.512	5	5	6
96	R:R:R393	6.4625	4	0	4
97	R:R:Y394	6.545	4	0	4
98	S:S:N75	6.1075	4	11	5
99	S:S:I85	3.766	5	0	6
100	S:S:T88	3.49	4	2	7
101	S:S:N92	6.7325	4	0	9
102	S:S:V95	3.926	5	4	9
103	S:S:L105	9.606	5	4	8
104	S:S:N110	7.31	4	4	9
105	S:S:F112	6.996	5	19	8
106	S:S:D120	7.4275	4	2	9
107	S:S:V127	4.445	4	2	8
108	S:S:M128	4.75429	7	2	8
109	S:S:M132	4.79	4	0	6
110	S:S:Y139	9.005	4	0	3
111	S:S:W141	8.86167	6	2	7
112	S:S:C148	7.525	4	2	9
113	S:S:W151	7.152	5	2	5
114	S:S:Y153	4.42	4	2	6
115	S:S:D155	8.516	5	2	8
116	S:S:V156	7.8275	4	2	6
117	S:S:F158	7.7025	4	0	7
118	S:S:I163	4.5975	4	2	8
119	S:S:L166	5.182	5	2	8
120	S:S:R173	5.105	4	6	9
121	S:S:I177	3.762	5	6	9
122	S:S:W200	3.7975	4	0	9
123	S:S:I210	4.718	5	2	6
124	S:S:V221	3.716	5	0	3
125	S:S:F222	6.0825	4	2	2
126	S:S:C227	7.4375	4	2	9
127	S:S:L229	5.405	4	0	4
128	S:S:F234	5.135	4	0	7
129	S:S:S239	5.5575	4	2	6
130	S:S:F243	9.094	5	2	8
131	S:S:P246	4.265	4	0	9
132	S:S:M250	2.93	4	2	8
133	S:S:Y254	7.8375	4	2	9
134	S:S:I315	2.9325	4	0	5
135	S:S:V328	3.6475	4	2	8
136	S:S:F329	4.895	6	2	8
137	S:S:F332	5.938	5	2	9
138	S:S:W336	6.27625	8	2	8
139	S:S:F339	9.45	6	2	7
140	S:S:F340	12.152	5	2	7
141	S:S:N343	6.334	5	2	7
142	S:S:V347	3.84	4	0	5
143	S:S:F365	6.288	5	0	5
144	S:S:V366	5.6375	4	2	6
145	S:S:W367	7.68714	7	2	6
146	S:S:Y370	7.04714	7	2	7
147	S:S:V375	3.39	4	0	6
148	S:S:V379	1.9675	4	0	8
149	S:S:Y380	10.4525	4	4	9
150	S:S:T386	5.9575	4	4	6
151	S:S:Y387	8.04429	7	4	8
152	S:S:F391	6.384	5	4	6
153	U:U:?1	6.12563	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y370	23.9504	2.75	Yes	Yes	3	0	7
2	R:R:W367	R:R:Y370	29.7084	20.26	Yes	Yes	3	6	7
3	R:R:T81	R:R:W367	40.9434	10.92	No	Yes	0	6	6
4	R:R:M132	R:R:T81	41.048	12.04	Yes	No	0	6	6
5	R:R:A82	R:R:M132	44.7052	3.22	No	Yes	0	3	6
6	R:R:A82	R:R:L79	44.8086	4.73	No	No	0	3	4
7	R:R:L79	S:S:V204	44.9119	1.49	No	No	0	4	4
8	S:S:L157	S:S:V204	45.0151	5.96	No	No	0	6	4
9	S:S:F158	S:S:L157	39.2225	7.31	Yes	No	0	7	6
10	S:S:F158	S:S:L123	39.8969	7.31	Yes	No	0	7	7
11	M:M:?1	S:S:W336	23.0996	2.67	Yes	Yes	2	0	8
12	S:S:L123	S:S:M128	42.1558	2.83	No	Yes	0	7	8
13	S:S:M128	S:S:T88	67.8947	3.01	Yes	Yes	2	8	7
14	S:S:N92	S:S:T88	68.2202	4.39	Yes	Yes	0	9	7
15	S:S:A117	S:S:N92	38.5675	4.69	No	Yes	0	9	9
16	S:S:A117	S:S:V95	38.5678	3.39	No	Yes	0	9	9
17	S:S:F391	S:S:V95	87.6552	2.62	Yes	Yes	4	6	9
18	S:S:F391	S:S:L94	100	13.4	Yes	No	0	6	6
19	S:S:I395	S:S:L94	99.8998	2.85	No	No	0	6	6
20	P:P:T190	S:S:I395	99.699	6.08	No	No	0	5	6
21	P:P:T190	S:S:Q396	99.4977	5.67	No	No	0	5	4
22	P:P:R189	S:S:Q396	99.3967	18.69	Yes	No	0	4	4
23	P:P:R189	P:P:Y111	98.0231	10.29	Yes	Yes	8	4	4
24	P:P:V99	P:P:Y111	97.6585	2.52	No	Yes	0	7	4
25	P:P:V99	P:P:Y387	97.0347	2.52	No	Yes	0	7	8
26	P:P:Y380	P:P:Y387	93.2999	5.96	Yes	Yes	1	9	8
27	P:P:N376	P:P:Y380	88.8254	6.98	Yes	Yes	1	9	9
28	P:P:D120	P:P:N376	57.6648	4.04	Yes	Yes	1	9	9
29	P:P:D120	P:P:S373	32.9776	8.83	Yes	No	1	9	9
30	P:P:M128	P:P:S373	31.7062	3.07	Yes	No	1	8	9
31	S:S:N92	S:S:P377	38.6828	9.77	Yes	No	0	9	9
32	S:S:P377	S:S:V95	38.6834	3.53	No	Yes	0	9	9
33	P:P:L116	P:P:N376	31.4252	5.49	Yes	Yes	1	9	9
34	P:P:L116	P:P:L166	28.3986	4.15	Yes	Yes	1	9	8
35	P:P:D120	P:P:S162	24.8631	2.94	Yes	No	0	9	9
36	P:P:M128	P:P:Y370	24.9692	8.38	Yes	Yes	1	8	7
37	P:P:F332	P:P:L166	24.8179	4.87	Yes	Yes	1	9	8
38	P:P:F332	P:P:W336	40.1502	9.02	Yes	Yes	1	9	8
39	P:P:W336	U:U:?1	30.0169	2.67	Yes	Yes	1	8	0
40	P:P:W151	U:U:?1	13.5524	2.67	Yes	Yes	1	5	0
41	P:P:F332	P:P:S162	24.7167	2.64	Yes	No	0	9	9
42	P:P:Y370	U:U:?1	15.0474	4.58	Yes	Yes	1	7	0
43	P:P:W141	P:P:W151	16.3913	12.18	Yes	Yes	1	7	5
44	R:R:M128	R:R:S373	10.6101	3.07	Yes	No	3	8	9
45	R:R:D120	R:R:S373	10.4892	8.83	No	No	0	9	9
46	S:S:M128	S:S:Y370	24.8315	13.17	Yes	Yes	2	8	7
47	S:S:V95	S:S:Y380	12.1315	7.57	Yes	Yes	4	9	9
48	S:S:F332	S:S:W336	16.5738	7.02	Yes	Yes	2	9	8
49	S:S:N376	S:S:V328	14.8014	7.39	No	Yes	0	9	8
50	R:R:M128	R:R:W367	10.4977	4.65	Yes	Yes	3	8	6
51	S:S:N376	S:S:Y380	24.2168	4.65	No	Yes	0	9	9
52	S:S:Y380	S:S:Y387	12.3635	17.87	Yes	Yes	4	9	8
53	S:S:F391	S:S:Y387	12.8434	4.13	Yes	Yes	4	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
P:P:L123	P:P:V127	4.47	1	No	Yes	7	8	2	2
P:P:D155	P:P:L123	4.07	1	Yes	No	8	7	1	2
P:P:V127	P:P:W151	8.58	1	Yes	Yes	8	5	2	1
P:P:D155	P:P:V127	10.22	1	Yes	Yes	8	8	1	2
P:P:V127	P:P:Y370	2.52	1	Yes	Yes	8	7	2	1
P:P:M128	P:P:W367	6.98	1	Yes	Yes	8	6	2	2
P:P:M128	P:P:Y370	8.38	1	Yes	Yes	8	7	2	1
P:P:V130	P:P:W151	8.58	0	No	Yes	4	5	2	1
P:P:S131	P:P:W151	4.94	1	No	Yes	7	5	2	1
P:P:S131	P:P:W367	3.71	1	No	Yes	7	6	2	2
P:P:S131	P:P:Y370	5.09	1	No	Yes	7	7	2	1
P:P:N363	P:P:Y139	15.12	0	No	No	4	3	1	2
P:P:W141	P:P:W151	12.18	1	Yes	Yes	7	5	2	1
P:P:C227	P:P:W141	11.75	1	Yes	Yes	9	7	2	2
P:P:C227	P:P:W151	5.22	1	Yes	Yes	9	5	2	1
P:P:W151	U:U:?1	2.67	1	Yes	Yes	5	0	1	0
P:P:I152	P:P:I210	2.94	0	No	Yes	5	6	2	2
P:P:C227	P:P:I152	3.27	1	Yes	No	9	5	2	2
P:P:I152	P:P:L229	4.28	0	No	Yes	5	4	2	1
P:P:D155	P:P:Y370	10.34	1	Yes	Yes	8	7	1	1
P:P:D155	U:U:?1	9.55	1	Yes	Yes	8	0	1	0
P:P:I210	P:P:V156	4.61	10	Yes	No	6	6	2	1
P:P:V156	U:U:?1	10.48	0	No	Yes	6	0	1	0
P:P:S159	P:P:W336	3.71	1	No	Yes	7	8	1	1
P:P:S159	U:U:?1	7.04	1	No	Yes	7	0	1	0
P:P:S242	P:P:T160	6.4	0	No	No	6	7	1	2
P:P:F234	P:P:I210	6.28	10	Yes	Yes	7	6	2	2
P:P:K220	P:P:L229	4.23	12	Yes	Yes	3	4	2	1
P:P:K223	P:P:L228	2.82	0	No	No	3	4	2	1
P:P:L228	P:P:S226	4.5	0	No	No	4	4	1	2
P:P:L228	U:U:?1	3.25	0	No	Yes	4	0	1	0
P:P:F234	P:P:L229	4.87	10	Yes	Yes	7	4	2	1
P:P:L229	P:P:V235	4.47	0	Yes	No	4	6	1	2
P:P:L229	U:U:?1	7.57	0	Yes	Yes	4	0	1	0
P:P:F234	P:P:G238	3.01	10	Yes	No	7	6	2	1
P:P:N343	P:P:V235	4.43	1	Yes	No	7	6	1	2
P:P:G238	P:P:I237	3.53	0	No	No	6	4	1	2
P:P:G238	U:U:?1	2.67	0	No	Yes	6	0	1	0
P:P:F340	P:P:S239	3.96	1	Yes	No	7	6	1	2
P:P:S242	U:U:?1	4.7	0	No	Yes	6	0	1	0
P:P:F243	P:P:F332	3.22	1	Yes	Yes	8	9	2	2
P:P:F243	P:P:W336	4.01	1	Yes	Yes	8	8	2	1
P:P:F243	P:P:F340	18.22	1	Yes	Yes	8	7	2	1
P:P:F332	P:P:W336	9.02	1	Yes	Yes	9	8	2	1
P:P:F332	P:P:S372	2.64	1	Yes	No	9	9	2	2
P:P:F339	P:P:W336	8.02	1	Yes	Yes	7	8	1	1
P:P:F340	P:P:W336	8.02	1	Yes	Yes	7	8	1	1
P:P:G369	P:P:W336	9.85	0	No	Yes	7	8	2	1
P:P:W336	P:P:Y370	3.86	1	Yes	Yes	8	7	1	1
P:P:S372	P:P:W336	6.18	1	No	Yes	9	8	2	1
P:P:W336	U:U:?1	2.67	1	Yes	Yes	8	0	1	0
P:P:F339	P:P:F340	7.5	1	Yes	Yes	7	7	1	1
P:P:F339	P:P:N343	9.67	1	Yes	Yes	7	7	1	1
P:P:F339	P:P:L362	6.09	1	Yes	Yes	7	3	1	1
P:P:F339	P:P:V366	7.87	1	Yes	No	7	6	1	1
P:P:F339	U:U:?1	12.38	1	Yes	Yes	7	0	1	0
P:P:F340	P:P:N343	3.62	1	Yes	Yes	7	7	1	1
P:P:F340	U:U:?1	16.19	1	Yes	Yes	7	0	1	0
P:P:L362	P:P:T342	4.42	1	Yes	No	3	5	1	2
P:P:L362	P:P:N343	6.87	1	Yes	Yes	3	7	1	1
P:P:N343	U:U:?1	3.22	1	Yes	Yes	7	0	1	0
P:P:L362	U:U:?1	4.33	1	Yes	Yes	3	0	1	0
P:P:N363	U:U:?1	3.22	0	No	Yes	4	0	1	0
P:P:V366	P:P:Y370	8.83	1	No	Yes	6	7	1	1
P:P:V366	U:U:?1	3.49	1	No	Yes	6	0	1	0
P:P:W367	P:P:Y370	19.29	1	Yes	Yes	6	7	2	1
P:P:Y370	U:U:?1	4.58	1	Yes	Yes	7	0	1	0
P:P:G359	P:P:L362	1.71	0	No	Yes	2	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:?1	S:S:W151	4.45	2	Yes	Yes	0	5	0	1
M:M:?1	S:S:D155	23.34	2	Yes	Yes	0	8	0	1
M:M:?1	S:S:V156	17.47	2	Yes	Yes	0	6	0	1
M:M:?1	S:S:S159	9.39	2	Yes	No	0	7	0	1
M:M:?1	S:S:L229	5.41	2	Yes	Yes	0	4	0	1
M:M:?1	S:S:G238	4.01	2	Yes	No	0	6	0	1
M:M:?1	S:S:S239	8.22	2	Yes	Yes	0	6	0	1
M:M:?1	S:S:S242	4.7	2	Yes	No	0	6	0	1
M:M:?1	S:S:W336	2.67	2	Yes	Yes	0	8	0	1
M:M:?1	S:S:F339	13.33	2	Yes	Yes	0	7	0	1
M:M:?1	S:S:F340	9.52	2	Yes	Yes	0	7	0	1
M:M:?1	S:S:N343	5.37	2	Yes	Yes	0	7	0	1
M:M:?1	S:S:V366	3.49	2	Yes	Yes	0	6	0	1
S:S:V127	S:S:W151	3.68	2	Yes	Yes	8	5	2	1
S:S:D155	S:S:V127	5.84	2	Yes	Yes	8	8	1	2
S:S:V127	S:S:Y370	3.79	2	Yes	Yes	8	7	2	2
S:S:V130	S:S:W151	14.71	0	No	Yes	4	5	2	1
S:S:W141	S:S:W151	10.31	2	Yes	Yes	7	5	2	1
S:S:C227	S:S:W141	15.67	2	Yes	Yes	9	7	2	2
S:S:C227	S:S:W151	2.61	2	Yes	Yes	9	5	2	1
S:S:I152	S:S:I210	4.42	0	No	Yes	5	6	2	2
S:S:I152	S:S:L229	7.14	0	No	Yes	5	4	2	1
S:S:D155	S:S:V156	4.38	2	Yes	Yes	8	6	1	1
S:S:D155	S:S:S159	4.42	2	Yes	No	8	7	1	1
S:S:D155	S:S:Y370	4.6	2	Yes	Yes	8	7	1	2
S:S:S207	S:S:V156	4.85	0	No	Yes	7	6	2	1
S:S:I210	S:S:V156	4.61	2	Yes	Yes	6	6	2	1
S:S:S242	S:S:T160	7.99	0	No	No	6	7	1	2
S:S:F234	S:S:I210	7.54	0	Yes	Yes	7	6	2	2
S:S:K223	S:S:L228	5.64	0	No	No	3	4	2	1
S:S:L228	S:S:S226	4.5	0	No	No	4	4	1	2
S:S:F234	S:S:L229	6.09	0	Yes	Yes	7	4	2	1
S:S:L229	S:S:V235	2.98	0	Yes	No	4	6	1	2
S:S:F234	S:S:G238	4.52	0	Yes	No	7	6	2	1
S:S:N343	S:S:V235	5.91	2	Yes	No	7	6	1	2
S:S:G238	S:S:I237	3.53	0	No	No	6	4	1	2
S:S:F340	S:S:S239	7.93	2	Yes	Yes	7	6	1	1
S:S:N343	S:S:S239	2.98	2	Yes	Yes	7	6	1	1
S:S:I344	S:S:S239	3.1	0	No	Yes	5	6	2	1
S:S:F243	S:S:W336	3.01	2	Yes	Yes	8	8	2	1
S:S:F243	S:S:F340	21.43	2	Yes	Yes	8	7	2	1
S:S:F332	S:S:W336	7.02	2	Yes	Yes	9	8	2	1
S:S:F332	S:S:S372	3.96	2	Yes	No	9	9	2	2
S:S:F339	S:S:W336	7.02	2	Yes	Yes	7	8	1	1
S:S:F340	S:S:W336	9.02	2	Yes	Yes	7	8	1	1
S:S:G369	S:S:W336	12.67	0	No	Yes	7	8	2	1
S:S:W336	S:S:Y370	3.86	2	Yes	Yes	8	7	1	2
S:S:S372	S:S:W336	4.94	2	No	Yes	9	8	2	1
S:S:F339	S:S:F340	12.86	2	Yes	Yes	7	7	1	1
S:S:F339	S:S:N343	13.29	2	Yes	Yes	7	7	1	1
S:S:F339	S:S:L362	3.65	2	Yes	No	7	3	1	2
S:S:F339	S:S:V366	6.55	2	Yes	Yes	7	6	1	1
S:S:L362	S:S:N343	4.12	2	No	Yes	3	7	2	1
S:S:V366	S:S:W367	3.68	2	Yes	Yes	6	6	1	2
S:S:V366	S:S:Y370	8.83	2	Yes	Yes	6	7	1	2
S:S:W367	S:S:Y370	12.54	2	Yes	Yes	6	7	2	2
M:M:?1	S:S:L228	2.16	2	Yes	No	0	4	0	1
S:S:S242	S:S:V241	1.62	0	No	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W151	8.01	3	Yes	Yes	0	5	0	1
L:L:?1	R:R:D155	16.97	3	Yes	Yes	0	8	0	1
L:L:?1	R:R:V156	16.3	3	Yes	No	0	6	0	1
L:L:?1	R:R:S159	3.52	3	Yes	No	0	7	0	1
L:L:?1	R:R:L229	6.49	3	Yes	Yes	0	4	0	1
L:L:?1	R:R:F234	2.86	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:S242	5.87	3	Yes	No	0	6	0	1
L:L:?1	R:R:W336	2.67	3	Yes	Yes	0	8	0	1
L:L:?1	R:R:F339	20.95	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	10.47	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:N343	3.22	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y370	2.75	3	Yes	Yes	0	7	0	1
R:R:L123	R:R:V127	4.47	3	Yes	Yes	7	8	2	2
R:R:D155	R:R:L123	2.71	3	Yes	Yes	8	7	1	2
R:R:L123	R:R:S159	4.5	3	Yes	No	7	7	2	1
R:R:L123	R:R:Y370	5.86	3	Yes	Yes	7	7	2	1
R:R:V127	R:R:W151	6.13	3	Yes	Yes	8	5	2	1
R:R:D155	R:R:V127	8.76	3	Yes	Yes	8	8	1	2
R:R:V127	R:R:Y370	5.05	3	Yes	Yes	8	7	2	1
R:R:M128	R:R:W367	4.65	3	Yes	Yes	8	6	2	2
R:R:M128	R:R:Y370	11.97	3	Yes	Yes	8	7	2	1
R:R:V130	R:R:W141	3.68	3	No	Yes	4	7	2	2
R:R:V130	R:R:W151	17.16	3	No	Yes	4	5	2	1
R:R:S131	R:R:W151	4.94	3	No	Yes	7	5	2	1
R:R:S131	R:R:W367	7.41	3	No	Yes	7	6	2	2
R:R:S131	R:R:Y370	6.36	3	No	Yes	7	7	2	1
R:R:W141	R:R:W151	12.18	3	Yes	Yes	7	5	2	1
R:R:C227	R:R:W141	18.28	3	No	Yes	9	7	2	2
R:R:C227	R:R:W151	5.22	3	No	Yes	9	5	2	1
R:R:I152	R:R:L229	7.14	0	No	Yes	5	4	2	1
R:R:D155	R:R:S159	4.42	3	Yes	No	8	7	1	1
R:R:D155	R:R:Y370	10.34	3	Yes	Yes	8	7	1	1
R:R:S207	R:R:V156	4.85	0	No	No	7	6	2	1
R:R:I210	R:R:V156	4.61	3	Yes	No	6	6	2	1
R:R:S242	R:R:T160	6.4	0	No	Yes	6	7	1	2
R:R:F234	R:R:P209	4.33	3	Yes	No	7	7	1	2
R:R:I210	R:R:L229	2.85	3	Yes	Yes	6	4	2	1
R:R:F234	R:R:I210	8.79	3	Yes	Yes	7	6	1	2
R:R:D231	R:R:F213	11.94	3	No	No	5	4	2	2
R:R:F213	R:R:F234	4.29	3	No	Yes	4	7	2	1
R:R:F234	R:R:L229	4.87	3	Yes	Yes	7	4	1	1
R:R:L229	R:R:V235	5.96	3	Yes	No	4	6	1	2
R:R:D231	R:R:F234	4.78	3	No	Yes	5	7	2	1
R:R:N343	R:R:V235	5.91	3	Yes	No	7	6	1	2
R:R:N343	R:R:S239	4.47	3	Yes	No	7	6	1	2
R:R:F243	R:R:W336	3.01	3	Yes	Yes	8	8	2	1
R:R:F243	R:R:F340	23.58	3	Yes	Yes	8	7	2	1
R:R:F332	R:R:W336	8.02	3	Yes	Yes	9	8	2	1
R:R:F332	R:R:S372	6.61	3	Yes	No	9	9	2	2
R:R:F339	R:R:W336	7.02	3	Yes	Yes	7	8	1	1
R:R:F340	R:R:W336	9.02	3	Yes	Yes	7	8	1	1
R:R:G369	R:R:W336	11.26	0	No	Yes	7	8	2	1
R:R:S372	R:R:W336	6.18	3	No	Yes	9	8	2	1
R:R:F339	R:R:F340	7.5	3	Yes	Yes	7	7	1	1
R:R:F339	R:R:N343	4.83	3	Yes	Yes	7	7	1	1
R:R:F339	R:R:L362	4.87	3	Yes	Yes	7	3	1	2
R:R:F339	R:R:V366	9.18	3	Yes	No	7	6	1	2
R:R:L362	R:R:N343	5.49	3	Yes	Yes	3	7	2	1
R:R:V366	R:R:Y370	7.57	0	No	Yes	6	7	2	1
R:R:W367	R:R:Y370	20.26	3	Yes	Yes	6	7	2	1
R:R:G238	R:R:S242	1.86	0	No	No	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6WGT_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.52
Number of Linked Nodes	791
Number of Links	969
Number of Hubs	153
Number of Links mediated by Hubs	574
Number of Communities	19
Number of Nodes involved in Communities	194
Number of Links involved in Communities	302

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	1705100
Length Of Smallest Path	3
Average Path Length	28.0996
Length of Longest Path	54
Minimum Path Strength	1.11
Average Path Strength	6.1264
Maximum Path Strength	18.96
Minimum Path Correlation	0.7
Average Path Correlation	0.992034
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	50.6514
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	56.6639
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	7LD
PDB Residues	L:L:?1 M:M:?1 U:U:?1
Environment Details	Open EMBL-EBI Page
Code	7LD
Name	Lysergic acid diethylamide
Synonyms	N,N-diethyllysergamide
Identifier
Formula	C20 H25 N3 O
Molecular Weight	323.432
SMILES
PubChem	5761
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>6WGT_poly_Chain_R H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q S K V F K E G S C L L A D D N F V L I G S F V S F F I P A T I M V I T Y F L T I K S L Q K E A T M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C K E S C N E D V I G A L L N V F V W I G Y A S S A V N P L V Y T L F N K T Y R S A F S R Y I Q C Q Y K P I S R F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	10.1021/acs.jmedchem.4c01244
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	10.1126/science.adn6354
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	10.1126/science.adn6354
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	To be published
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	10.1038/s41586-022-05258-z
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	10.1126/science.abl8615
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	10.1126/science.abl8615
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	10.1038/s41593-021-00971-w
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	10.1038/s41593-021-00971-w
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WH4 (Multimeric)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-		3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WGT (Multimeric)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	10.1016/j.cell.2020.08.024
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	10.1038/s41594-018-0180-z
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	10.1038/s41594-018-0180-z

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Download 6WGT_poly.zip

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