psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:E73	S:S:Q72	3.82	No	No	0	3	1
2	S:S:K74	S:S:S77	3.06	No	No	0	6	3
3	R:R:M208	S:S:N75	2.8	No	Yes	1	4	5
4	R:R:P209	S:S:N75	8.15	No	Yes	1	7	5
5	S:S:A82	S:S:L79	4.73	No	No	0	3	4
6	R:R:V204	S:S:L79	1.49	No	No	0	4	4
7	S:S:L80	S:S:V83	2.98	No	No	0	4	4
8	S:S:M132	S:S:T81	12.04	No	No	0	6	6
9	S:S:T81	S:S:W367	10.92	No	Yes	0	6	6
10	S:S:A82	S:S:M132	3.22	No	No	0	3	6
11	S:S:L87	S:S:V83	2.98	No	No	0	4	4
12	S:S:T88	S:S:V84	1.59	Yes	Yes	2	7	7
13	S:S:M128	S:S:V84	1.52	Yes	Yes	2	8	7
14	S:S:V84	S:S:W367	3.68	Yes	Yes	2	7	6
15	S:S:A371	S:S:V84	5.09	No	Yes	0	4	7
16	S:S:I85	S:S:M128	4.37	No	Yes	2	6	8
17	S:S:I85	S:S:P129	3.39	No	No	2	6	8
18	S:S:I85	S:S:W367	2.35	No	Yes	2	6	6
19	S:S:A374	S:S:L87	1.58	No	No	0	6	4
20	S:S:I89	S:S:T88	1.52	No	Yes	0	5	7
21	S:S:G124	S:S:T88	1.82	No	Yes	2	6	7
22	S:S:M128	S:S:T88	4.52	Yes	Yes	2	8	7
23	S:S:S373	S:S:T88	3.2	Yes	Yes	2	9	7
24	S:S:A374	S:S:T88	3.36	No	Yes	0	6	7
25	S:S:A90	S:S:I89	1.62	No	No	0	4	5
26	S:S:F125	S:S:I89	8.79	No	No	0	4	5
27	S:S:A90	S:S:G91	1.95	No	No	0	4	8
28	S:S:A90	S:S:I93	1.62	No	No	0	4	3
29	S:S:G91	S:S:L94	3.42	No	Yes	0	8	6
30	S:S:G91	S:S:P377	4.06	No	Yes	0	8	9
31	S:S:I96	S:S:N92	2.83	Yes	Yes	2	6	9
32	S:S:A117	S:S:N92	4.69	No	Yes	2	9	9
33	S:S:D120	S:S:N92	10.77	No	Yes	0	9	9
34	S:S:M121	S:S:N92	5.61	No	Yes	2	7	9
35	S:S:N92	S:S:P377	1.63	Yes	Yes	0	9	9
36	S:S:I93	S:S:L94	2.85	No	Yes	0	3	6
37	S:S:I93	S:S:M121	8.75	No	No	0	3	7
38	S:S:F391	S:S:L94	9.74	Yes	Yes	0	6	6
39	S:S:I395	S:S:L94	2.85	No	Yes	0	6	6
40	S:S:A117	S:S:V95	3.39	No	Yes	2	9	9
41	S:S:P377	S:S:V95	3.53	Yes	Yes	0	9	9
42	S:S:V95	S:S:Y380	3.79	Yes	Yes	2	9	9
43	S:S:V95	S:S:Y387	2.52	Yes	Yes	2	9	8
44	S:S:F391	S:S:V95	5.24	Yes	Yes	2	6	9
45	S:S:I96	S:S:M114	4.37	Yes	No	0	6	5
46	S:S:A117	S:S:I96	1.62	No	Yes	2	9	6
47	S:S:I118	S:S:I96	5.89	No	Yes	0	6	6
48	S:S:I96	S:S:M121	2.92	Yes	No	2	6	7
49	S:S:M97	S:S:Y394	4.79	No	Yes	0	4	4
50	S:S:A98	S:S:L105	1.58	Yes	Yes	2	7	8
51	S:S:A98	S:S:Y387	2.67	Yes	Yes	2	7	8
52	S:S:A390	S:S:A98	1.79	No	Yes	2	7	7
53	S:S:A98	S:S:F391	2.77	Yes	Yes	2	7	6
54	S:S:A98	S:S:Y394	5.34	Yes	Yes	2	7	4
55	S:S:M114	S:S:V99	9.13	No	No	0	5	7
56	S:S:V99	S:S:Y387	3.79	No	Yes	0	7	8
57	S:S:L101	S:S:S100	3	No	No	0	5	1
58	S:S:L101	S:S:Y394	9.38	No	Yes	0	5	4
59	S:S:K104	S:S:T386	4.5	No	No	0	6	6
60	S:S:L105	S:S:N110	4.12	Yes	No	0	8	9
61	S:S:L105	S:S:T386	7.37	Yes	No	0	8	6
62	S:S:L105	S:S:Y387	8.21	Yes	Yes	2	8	8
63	S:S:Q106	S:S:Y111	2.25	No	No	0	7	4
64	S:S:A108	S:S:N107	1.56	No	No	0	5	7
65	S:S:N107	S:S:T109	2.92	No	No	0	7	8
66	S:S:N107	S:S:N110	10.9	No	No	0	7	9
67	S:S:A108	S:S:A192	1.79	No	No	0	5	7
68	S:S:R173	S:S:T109	5.17	Yes	No	0	9	8
69	S:S:A192	S:S:Y111	4	No	No	0	7	4
70	S:S:A168	S:S:F112	2.77	No	Yes	0	7	8
71	S:S:F112	S:S:I169	8.79	Yes	No	0	8	9
72	S:S:D172	S:S:F112	3.58	No	Yes	4	9	8
73	S:S:F112	S:S:K195	4.96	Yes	No	4	8	6
74	S:S:F112	S:S:I196	3.77	Yes	No	4	8	8
75	S:S:L113	S:S:Y380	11.72	No	Yes	2	8	9
76	S:S:L113	S:S:Y387	2.34	No	Yes	2	8	8
77	S:S:H165	S:S:S115	8.37	Yes	No	4	8	9
78	S:S:I196	S:S:S115	10.84	No	No	4	8	9
79	S:S:S115	S:S:W200	4.94	No	Yes	4	9	9
80	S:S:L116	S:S:S162	1.5	No	No	0	9	9
81	S:S:H165	S:S:L116	6.43	Yes	No	0	8	9
82	S:S:L116	S:S:L166	2.77	No	Yes	0	9	8
83	S:S:I118	S:S:L122	4.28	No	No	0	6	7
84	S:S:A119	S:S:A161	1.79	No	No	4	8	8
85	S:S:A119	S:S:S162	1.71	No	No	0	8	9
86	S:S:A119	S:S:W200	3.89	No	Yes	4	8	9
87	S:S:D120	S:S:S373	8.83	No	Yes	0	9	9
88	S:S:D120	S:S:N376	2.69	No	Yes	0	9	9
89	S:S:F158	S:S:L122	13.4	Yes	No	0	7	7
90	S:S:L123	S:S:V127	4.47	Yes	Yes	2	7	8
91	S:S:D155	S:S:L123	2.71	Yes	Yes	2	8	7
92	S:S:F158	S:S:L123	8.53	Yes	Yes	0	7	7
93	S:S:L123	S:S:S159	4.5	Yes	No	2	7	7
94	S:S:L123	S:S:Y370	5.86	Yes	Yes	2	7	7
95	S:S:L123	S:S:S373	1.5	Yes	Yes	2	7	9
96	S:S:G124	S:S:M128	5.24	No	Yes	2	6	8
97	S:S:F125	S:S:L126	3.65	No	No	0	4	5
98	S:S:L126	S:S:L154	5.54	No	No	0	5	5
99	S:S:F158	S:S:L126	3.65	Yes	No	0	7	5
100	S:S:V127	S:S:W151	6.13	Yes	Yes	2	8	5
101	S:S:L154	S:S:V127	2.98	No	Yes	0	5	8
102	S:S:D155	S:S:V127	8.76	Yes	Yes	2	8	8
103	S:S:V127	S:S:Y370	5.05	Yes	Yes	2	8	7
104	S:S:M128	S:S:P129	1.68	Yes	No	2	8	8
105	S:S:M128	S:S:W367	4.65	Yes	Yes	2	8	6
106	S:S:M128	S:S:Y370	11.97	Yes	Yes	2	8	7
107	S:S:M128	S:S:S373	3.07	Yes	Yes	2	8	9
108	S:S:L133	S:S:V130	1.49	No	Yes	2	4	4
109	S:S:V130	S:S:W141	3.68	Yes	Yes	2	4	7
110	S:S:L143	S:S:V130	1.49	Yes	Yes	2	5	4
111	S:S:V130	S:S:W151	17.16	Yes	Yes	2	4	5
112	S:S:S131	S:S:W151	4.94	No	Yes	2	7	5
113	S:S:S131	S:S:W367	7.41	No	Yes	2	7	6
114	S:S:S131	S:S:Y370	6.36	No	Yes	2	7	7
115	S:S:L133	S:S:P142	6.57	No	Yes	2	4	3
116	S:S:L133	S:S:L143	2.77	No	Yes	2	4	5
117	S:S:T134	S:S:Y139	3.75	No	Yes	0	5	3
118	S:S:T134	S:S:W141	4.85	No	Yes	2	5	7
119	S:S:P142	S:S:T134	3.5	Yes	No	2	3	5
120	S:S:I135	S:S:Y139	13.3	No	Yes	0	5	3
121	S:S:I135	S:S:W367	5.87	No	Yes	0	5	6
122	S:S:P142	S:S:Y137	12.52	Yes	No	0	3	4
123	S:S:N363	S:S:Y139	17.44	No	Yes	0	4	3
124	S:S:P142	S:S:W141	6.76	Yes	Yes	2	3	7
125	S:S:L143	S:S:W141	7.97	Yes	Yes	2	5	7
126	S:S:C148	S:S:W141	6.53	Yes	Yes	2	9	7
127	S:S:W141	S:S:W151	12.18	Yes	Yes	2	7	5
128	S:S:F222	S:S:W141	6.01	Yes	Yes	2	2	7
129	S:S:C227	S:S:W141	18.28	No	Yes	2	9	7
130	S:S:L143	S:S:P142	4.93	Yes	Yes	2	5	3
131	S:S:L143	S:S:P144	1.64	Yes	No	0	5	7
132	S:S:L147	S:S:P144	4.93	No	No	0	5	7
133	S:S:K146	S:S:S145	6.12	No	No	0	1	3
134	S:S:K146	S:S:L215	2.82	No	No	0	1	5
135	S:S:C148	S:S:V221	3.42	Yes	Yes	2	9	3
136	S:S:C148	S:S:F222	8.38	Yes	Yes	2	9	2
137	S:S:C148	S:S:C227	7.28	Yes	No	2	9	9
138	S:S:A149	S:S:G214	1.95	No	No	0	6	7
139	S:S:A149	S:S:V221	3.39	No	Yes	0	6	3
140	S:S:C227	S:S:W151	5.22	No	Yes	2	9	5
141	M:M:?1	S:S:W151	8.55	Yes	Yes	2	0	5
142	S:S:I152	S:S:V221	3.07	No	Yes	0	5	3
143	S:S:I152	S:S:L229	7.14	No	Yes	0	5	4
144	S:S:L154	S:S:Y153	2.34	No	Yes	0	5	6
145	S:S:S207	S:S:Y153	5.09	No	Yes	0	7	6
146	S:S:I210	S:S:Y153	4.84	Yes	Yes	2	6	6
147	S:S:P211	S:S:Y153	6.95	No	Yes	2	5	6
148	S:S:D155	S:S:S159	4.42	Yes	No	2	8	7
149	S:S:D155	S:S:Y370	10.34	Yes	Yes	2	8	7
150	M:M:?1	S:S:D155	18.11	Yes	Yes	2	0	8
151	S:S:S207	S:S:V156	4.85	No	No	0	7	6
152	S:S:I210	S:S:V156	4.61	Yes	No	0	6	6
153	M:M:?1	S:S:V156	17.4	Yes	No	0	0	6
154	S:S:F158	S:S:L157	7.31	Yes	Yes	0	7	6
155	S:S:L157	S:S:S203	1.5	Yes	Yes	0	6	8
156	S:S:L157	S:S:V204	1.49	Yes	No	0	6	4
157	S:S:L157	S:S:S207	6.01	Yes	No	0	6	7
158	S:S:F158	S:S:W200	4.01	Yes	Yes	0	7	9
159	M:M:?1	S:S:S159	3.76	Yes	No	2	0	7
160	S:S:M164	S:S:T160	4.52	Yes	Yes	4	6	7
161	S:S:S203	S:S:T160	4.8	Yes	Yes	4	8	7
162	S:S:I206	S:S:T160	6.08	No	Yes	0	6	7
163	S:S:S242	S:S:T160	6.4	No	Yes	0	6	7
164	S:S:A161	S:S:W200	5.19	No	Yes	4	8	9
165	S:S:A161	S:S:S203	3.42	No	Yes	4	8	8
166	S:S:F332	S:S:S162	2.64	Yes	No	0	9	9
167	S:S:F243	S:S:I163	2.51	Yes	Yes	0	8	8
168	S:S:I163	S:S:P246	8.47	Yes	Yes	0	8	9
169	S:S:A247	S:S:I163	1.62	No	Yes	0	6	8
170	S:S:F332	S:S:I163	6.28	Yes	Yes	0	9	8
171	S:S:M164	S:S:V199	1.52	Yes	No	0	6	6
172	S:S:M164	S:S:S203	4.6	Yes	Yes	4	6	8
173	S:S:M164	S:S:P246	5.03	Yes	Yes	0	6	9
174	S:S:H165	S:S:V199	11.07	Yes	No	0	8	6
175	S:S:H165	S:S:W200	9.52	Yes	Yes	4	8	9
176	S:S:L166	S:S:M250	4.24	Yes	Yes	2	8	8
177	S:S:L166	S:S:V328	1.49	Yes	Yes	2	8	8
178	S:S:F329	S:S:L166	4.87	Yes	Yes	2	8	8
179	S:S:F332	S:S:L166	8.53	Yes	Yes	2	9	8
180	S:S:C167	S:S:P246	1.88	No	Yes	0	6	9
181	S:S:C167	S:S:I249	3.27	No	No	0	6	6
182	S:S:C167	S:S:M250	4.86	No	Yes	0	6	8
183	S:S:A168	S:S:V199	1.7	No	No	0	7	6
184	S:S:F329	S:S:I169	3.77	Yes	No	0	8	9
185	S:S:M250	S:S:S170	1.53	Yes	No	2	8	9
186	S:S:S170	S:S:T253	4.8	No	No	0	9	5
187	S:S:F329	S:S:S170	7.93	Yes	No	2	8	9
188	S:S:L171	S:S:V175	1.49	No	No	0	6	5
189	S:S:D172	S:S:K195	11.06	No	No	4	9	6
190	S:S:E318	S:S:R173	5.82	No	Yes	0	8	9
191	S:S:C322	S:S:R173	4.18	No	Yes	0	7	9
192	S:S:L325	S:S:R173	3.64	No	Yes	0	8	9
193	S:S:I177	S:S:Y174	2.42	Yes	Yes	0	9	8
194	S:S:T253	S:S:Y174	4.99	No	Yes	0	5	8
195	S:S:L256	S:S:Y174	9.38	No	Yes	0	5	8
196	S:S:T257	S:S:Y174	3.75	No	Yes	0	9	8
197	S:S:I177	S:S:S260	9.29	Yes	No	0	9	6
198	S:S:I177	S:S:L261	7.14	Yes	No	0	9	8
199	S:S:E264	S:S:I177	4.1	No	Yes	0	7	9
200	S:S:N179	S:S:Q178	2.64	No	No	0	6	6
201	S:S:N179	S:S:P180	1.63	No	No	0	6	8
202	S:S:K191	S:S:R185	11.14	No	No	0	6	4
203	S:S:F186	S:S:N187	10.87	No	Yes	0	4	6
204	S:S:R189	S:S:S188	7.91	No	No	0	4	7
205	S:S:K191	S:S:S188	3.06	No	No	0	6	7
206	S:S:F193	S:S:I197	8.79	No	No	0	4	2
207	S:S:I196	S:S:W200	2.35	No	Yes	4	8	9
208	S:S:I197	S:S:T201	3.04	No	No	0	2	4
209	S:S:A198	S:S:T201	1.68	No	No	0	2	4
210	S:S:T201	S:S:V204	3.17	No	No	0	4	4
211	S:S:G205	S:S:V204	1.84	No	No	0	4	4
212	S:S:G205	S:S:M208	1.75	No	No	0	4	4
213	S:S:I206	S:S:V241	4.61	No	No	0	6	4
214	S:S:M208	S:S:P209	1.68	No	No	0	4	7
215	S:S:F234	S:S:P209	4.33	Yes	No	0	7	7
216	S:S:I210	S:S:P211	3.39	Yes	No	2	6	5
217	S:S:I210	S:S:L229	2.85	Yes	Yes	2	6	4
218	S:S:F234	S:S:I210	8.79	Yes	Yes	2	7	6
219	S:S:F213	S:S:G214	1.51	Yes	No	0	4	7
220	S:S:F213	S:S:K220	8.69	Yes	No	2	4	3
221	S:S:D231	S:S:F213	11.94	No	Yes	2	5	4
222	S:S:F213	S:S:F234	4.29	Yes	Yes	2	4	7
223	S:S:L215	S:S:S219	1.5	No	No	0	5	3
224	S:S:K220	S:S:S219	1.53	No	No	0	3	3
225	S:S:D231	S:S:K220	8.3	No	No	2	5	3
226	S:S:F222	S:S:V221	2.62	Yes	Yes	2	2	3
227	S:S:F222	S:S:G225	1.51	Yes	No	0	2	3
228	S:S:K223	S:S:L228	5.64	No	No	5	3	4
229	S:S:A230	S:S:K223	6.42	No	No	5	3	3
230	S:S:L228	S:S:S226	4.5	No	No	0	4	4
231	S:S:A230	S:S:L228	1.58	No	No	5	3	4
232	S:S:F234	S:S:L229	4.87	Yes	Yes	2	7	4
233	S:S:L229	S:S:V235	5.96	Yes	No	0	4	6
234	M:M:?1	S:S:L229	6.93	Yes	Yes	2	0	4
235	S:S:D231	S:S:F234	4.78	No	Yes	2	5	7
236	S:S:D232	S:S:V347	4.38	No	Yes	0	4	5
237	S:S:D232	S:S:K350	2.77	No	No	0	4	1
238	M:M:?1	S:S:F234	3.05	Yes	Yes	2	0	7
239	S:S:N343	S:S:V235	5.91	Yes	No	0	7	6
240	S:S:V235	S:S:V347	4.81	No	Yes	0	6	5
241	S:S:I344	S:S:L236	5.71	Yes	No	0	5	6
242	S:S:L236	S:S:V347	1.49	No	Yes	0	6	5
243	S:S:G238	S:S:I237	3.53	No	No	0	6	4
244	S:S:G238	S:S:V241	1.84	No	No	0	6	4
245	S:S:G238	S:S:S242	1.86	No	No	0	6	6
246	S:S:F244	S:S:S239	2.64	Yes	No	0	5	6
247	S:S:N343	S:S:S239	4.47	Yes	No	0	7	6
248	S:S:I344	S:S:S239	4.64	Yes	No	0	5	6
249	S:S:F240	S:S:F244	7.5	No	Yes	0	4	5
250	S:S:F240	S:S:I344	5.02	No	Yes	0	4	5
251	M:M:?1	S:S:S242	6.26	Yes	No	0	0	6
252	S:S:F243	S:S:F244	10.72	Yes	Yes	2	8	5
253	S:S:F243	S:S:W336	3.01	Yes	Yes	2	8	8
254	S:S:C337	S:S:F243	5.59	No	Yes	0	6	8
255	S:S:F243	S:S:F340	23.58	Yes	Yes	2	8	7
256	S:S:F244	S:S:F340	2.14	Yes	Yes	2	5	7
257	S:S:F244	S:S:I341	2.51	Yes	No	0	5	6
258	S:S:I245	S:S:P246	5.08	No	Yes	0	5	9
259	S:S:A247	S:S:V333	1.7	No	No	0	6	6
260	S:S:I252	S:S:T248	1.52	No	No	0	5	3
261	S:S:F329	S:S:M250	8.71	Yes	Yes	2	8	8
262	S:S:M250	S:S:V333	1.52	Yes	No	0	8	6
263	S:S:F255	S:S:V251	2.62	No	No	0	1	5
264	S:S:I252	S:S:L256	2.85	No	No	0	5	5
265	S:S:F255	S:S:Y254	13.41	No	Yes	0	1	9
266	S:S:I258	S:S:Y254	10.88	No	Yes	0	5	9
267	S:S:G326	S:S:Y254	7.24	No	Yes	2	6	9
268	S:S:F329	S:S:Y254	7.22	Yes	Yes	2	8	9
269	S:S:K259	S:S:L256	2.82	No	No	0	4	5
270	S:S:L261	S:S:T257	4.42	No	No	0	8	9
271	S:S:I258	S:S:Q262	4.12	No	No	0	5	6
272	S:S:C322	S:S:I258	6.55	No	No	0	7	5
273	S:S:A265	S:S:I315	1.62	No	No	0	5	5
274	S:S:A265	S:S:Q319	1.52	No	No	0	5	5
275	S:S:M312	S:S:T311	1.51	No	No	0	4	4
276	S:S:S314	S:S:T311	1.6	No	No	0	5	4
277	S:S:N317	S:S:Q313	2.64	No	No	0	6	5
278	S:S:I315	S:S:S314	1.55	No	No	0	5	5
279	S:S:N317	S:S:S316	2.98	No	No	0	6	6
280	S:S:K320	S:S:S316	3.06	No	No	0	8	6
281	S:S:F383	S:S:K323	2.48	No	No	0	7	7
282	S:S:L325	S:S:V324	1.49	No	Yes	0	8	8
283	S:S:V324	S:S:V328	1.6	Yes	Yes	2	8	8
284	S:S:V324	S:S:V379	4.81	Yes	Yes	2	8	8
285	S:S:V324	S:S:Y380	2.52	Yes	Yes	2	8	9
286	S:S:F383	S:S:V324	2.62	No	Yes	0	7	8
287	S:S:F329	S:S:L325	2.44	Yes	No	0	8	8
288	S:S:F329	S:S:G326	1.51	Yes	No	2	8	6
289	S:S:I327	S:S:V379	3.07	No	Yes	0	6	8
290	S:S:N376	S:S:V328	5.91	Yes	Yes	0	9	8
291	S:S:V328	S:S:V379	4.81	Yes	Yes	2	8	8
292	S:S:F330	S:S:L331	2.44	No	No	0	5	6
293	S:S:F330	S:S:V334	3.93	No	No	0	5	5
294	S:S:L331	S:S:V375	4.47	No	No	0	6	6
295	S:S:F332	S:S:W336	8.02	Yes	Yes	2	9	8
296	S:S:F332	S:S:S372	6.61	Yes	Yes	2	9	9
297	S:S:M335	S:S:V334	1.52	Yes	No	0	8	5
298	S:S:G369	S:S:M335	1.75	No	Yes	0	7	8
299	S:S:A371	S:S:M335	1.61	No	Yes	0	4	8
300	S:S:M335	S:S:S372	6.13	Yes	Yes	0	8	9
301	S:S:M335	S:S:V375	3.04	Yes	No	0	8	6
302	S:S:F339	S:S:W336	7.02	Yes	Yes	2	7	8
303	S:S:F340	S:S:W336	9.02	Yes	Yes	2	7	8
304	S:S:V366	S:S:W336	2.45	Yes	Yes	2	6	8
305	S:S:G369	S:S:W336	11.26	No	Yes	0	7	8
306	S:S:W336	S:S:Y370	1.93	Yes	Yes	2	8	7
307	S:S:S372	S:S:W336	6.18	Yes	Yes	2	9	8
308	M:M:?1	S:S:W336	2.85	Yes	Yes	2	0	8
309	S:S:C337	S:S:P338	1.88	No	No	0	6	9
310	S:S:C337	S:S:I341	3.27	No	No	0	6	6
311	S:S:F365	S:S:P338	7.22	Yes	No	0	5	9
312	S:S:F339	S:S:F340	7.5	Yes	Yes	2	7	7
313	S:S:F339	S:S:N343	4.83	Yes	Yes	2	7	7
314	S:S:F339	S:S:L362	4.87	Yes	Yes	2	7	3
315	S:S:F339	S:S:V366	9.18	Yes	Yes	2	7	6
316	M:M:?1	S:S:F339	22.35	Yes	Yes	2	0	7
317	M:M:?1	S:S:F340	11.18	Yes	Yes	2	0	7
318	S:S:L362	S:S:T342	5.9	Yes	No	0	3	5
319	S:S:F365	S:S:T342	3.89	Yes	No	0	5	5
320	S:S:L362	S:S:N343	5.49	Yes	Yes	2	3	7
321	M:M:?1	S:S:N343	3.44	Yes	Yes	2	0	7
322	S:S:I344	S:S:I348	4.42	Yes	No	0	5	4
323	S:S:I348	S:S:M345	4.37	No	No	5	4	4
324	S:S:C349	S:S:M345	1.62	Yes	No	5	3	4
325	S:S:A346	S:S:V347	1.7	No	Yes	0	4	5
326	S:S:A346	S:S:E355	1.51	No	Yes	5	4	3
327	S:S:A346	S:S:I358	3.25	No	Yes	5	4	4
328	S:S:C349	S:S:I348	1.64	Yes	No	5	3	4
329	S:S:C349	S:S:S352	3.44	Yes	No	0	3	2
330	S:S:C349	S:S:C353	7.28	Yes	No	5	3	3
331	S:S:E351	S:S:K350	8.1	No	No	0	5	1
332	S:S:C353	S:S:E355	1.52	No	Yes	5	3	3
333	S:S:C353	S:S:I358	6.55	No	Yes	5	3	4
334	S:S:D356	S:S:N354	5.39	No	No	0	2	1
335	S:S:N354	S:S:V357	4.43	No	No	0	1	5
336	S:S:E355	S:S:I358	4.1	Yes	Yes	5	3	4
337	S:S:L361	S:S:V357	2.98	No	No	0	4	5
338	S:S:G359	S:S:I358	1.76	No	Yes	0	2	4
339	S:S:G359	S:S:L362	1.71	No	Yes	0	2	3
340	S:S:G359	S:S:N363	1.7	No	No	0	2	4
341	S:S:F365	S:S:L361	6.09	Yes	No	0	5	4
342	S:S:F365	S:S:V364	2.62	Yes	No	0	5	4
343	S:S:F365	S:S:I368	3.77	Yes	No	0	5	7
344	S:S:V366	S:S:Y370	7.57	Yes	Yes	2	6	7
345	M:M:?1	S:S:V366	2.49	Yes	Yes	2	0	6
346	S:S:W367	S:S:Y370	20.26	Yes	Yes	2	6	7
347	S:S:G369	S:S:I368	1.76	No	No	0	7	7
348	M:M:?1	S:S:Y370	2.93	Yes	Yes	2	0	7
349	S:S:S372	S:S:S373	1.63	Yes	Yes	2	9	9
350	S:S:V375	S:S:V379	1.6	No	Yes	0	6	8
351	S:S:N376	S:S:P377	3.26	Yes	Yes	0	9	9
352	S:S:N376	S:S:Y380	5.81	Yes	Yes	0	9	9
353	S:S:Y380	S:S:Y387	11.91	Yes	Yes	2	9	8
354	S:S:L382	S:S:T381	2.95	No	No	0	5	7
355	S:S:F391	S:S:T381	2.59	Yes	No	0	6	7
356	S:S:F383	S:S:L382	6.09	No	No	0	7	5
357	S:S:N384	S:S:T386	5.85	No	No	0	9	6
358	S:S:N384	S:S:Y387	11.63	No	Yes	0	9	8
359	S:S:K385	S:S:R388	18.56	No	No	0	5	9
360	S:S:K385	S:S:S389	1.53	No	No	0	5	4
361	S:S:F391	S:S:Y387	7.22	Yes	Yes	2	6	8
362	S:S:R393	S:S:S389	6.59	No	No	0	4	4
363	S:S:A390	S:S:Y394	6.67	No	Yes	2	7	4
364	S:S:Q396	S:S:S392	2.89	No	No	3	4	3
365	R:R:T190	S:S:S392	4.8	Yes	No	3	5	3
366	S:S:Q398	S:S:R393	4.67	No	No	0	4	4
367	R:R:R189	S:S:Q396	7.01	Yes	No	3	4	4
368	R:R:T190	S:S:Q396	5.67	Yes	No	3	5	4
369	S:S:Q398	S:S:Y399	2.25	No	No	0	4	2
370	R:R:N75	R:R:Q72	3.96	No	No	0	5	1
371	R:R:Q72	R:R:W76	3.29	No	No	0	1	4
372	R:R:K74	R:R:L136	2.82	No	No	0	6	5
373	R:R:L79	R:R:V83	1.49	No	No	0	4	4
374	R:R:M132	R:R:T81	7.53	Yes	No	1	6	6
375	R:R:T81	R:R:W367	15.77	No	Yes	1	6	6
376	R:R:A82	R:R:M132	1.61	No	Yes	0	3	6
377	R:R:L87	R:R:V83	2.98	No	No	0	4	4
378	R:R:T88	R:R:V84	1.59	Yes	Yes	1	7	7
379	R:R:M128	R:R:V84	3.04	Yes	Yes	1	8	7
380	R:R:V84	R:R:W367	4.9	Yes	Yes	1	7	6
381	R:R:A371	R:R:V84	1.7	No	Yes	0	4	7
382	R:R:I85	R:R:I89	2.94	Yes	Yes	0	6	5
383	R:R:I85	R:R:M128	2.92	Yes	Yes	1	6	8
384	R:R:I85	R:R:P129	5.08	Yes	No	1	6	8
385	R:R:I85	R:R:M132	4.37	Yes	Yes	1	6	6
386	R:R:I85	R:R:W367	3.52	Yes	Yes	1	6	6
387	R:R:A374	R:R:L87	1.58	No	No	0	6	4
388	R:R:N92	R:R:T88	4.39	Yes	Yes	0	9	7
389	R:R:G124	R:R:T88	1.82	Yes	Yes	1	6	7
390	R:R:M128	R:R:T88	3.01	Yes	Yes	1	8	7
391	R:R:S373	R:R:T88	3.2	Yes	Yes	1	9	7
392	R:R:A374	R:R:T88	3.36	No	Yes	0	6	7
393	R:R:G124	R:R:I89	1.76	Yes	Yes	0	6	5
394	R:R:F125	R:R:I89	5.02	No	Yes	0	4	5
395	R:R:A90	R:R:G91	1.95	No	No	0	4	8
396	R:R:G91	R:R:L94	1.71	No	No	0	8	6
397	R:R:G91	R:R:P377	4.06	No	Yes	0	8	9
398	R:R:A117	R:R:N92	4.69	No	Yes	0	9	9
399	R:R:D120	R:R:N92	8.08	Yes	Yes	0	9	9
400	R:R:N92	R:R:P377	9.77	Yes	Yes	0	9	9
401	R:R:F391	R:R:L94	13.4	Yes	No	0	6	6
402	R:R:I395	R:R:L94	2.85	No	No	0	6	6
403	R:R:A117	R:R:V95	3.39	No	Yes	0	9	9
404	R:R:P377	R:R:V95	3.53	Yes	Yes	0	9	9
405	R:R:V95	R:R:Y380	7.57	Yes	Yes	3	9	9
406	R:R:V95	R:R:Y387	2.52	Yes	Yes	3	9	8
407	R:R:F391	R:R:V95	2.62	Yes	Yes	3	6	9
408	R:R:A117	R:R:I96	3.25	No	No	0	9	6
409	R:R:I118	R:R:I96	14.72	Yes	No	3	6	6
410	R:R:I96	R:R:M121	7.29	No	No	3	6	7
411	R:R:M97	R:R:Y394	3.59	No	Yes	0	4	4
412	R:R:A98	R:R:E102	3.02	No	Yes	6	7	6
413	R:R:A390	R:R:A98	1.79	No	No	6	7	7
414	R:R:A98	R:R:Y394	2.67	No	Yes	6	7	4
415	R:R:V99	R:R:Y111	2.52	No	Yes	3	7	4
416	R:R:M114	R:R:V99	7.61	No	No	3	5	7
417	R:R:V99	R:R:Y387	3.79	No	Yes	3	7	8
418	R:R:L101	R:R:S100	3	Yes	No	0	5	1
419	R:R:E102	R:R:L101	6.63	Yes	Yes	6	6	5
420	R:R:L101	R:R:Y394	18.76	Yes	Yes	6	5	4
421	R:R:L101	R:R:Y399	29.31	Yes	Yes	6	5	2
422	R:R:A390	R:R:E102	6.03	No	Yes	6	7	6
423	R:R:E102	R:R:R393	10.47	Yes	No	6	6	4
424	R:R:E102	R:R:Y394	19.08	Yes	Yes	6	6	4
425	R:R:E102	R:R:Y399	2.24	Yes	Yes	6	6	2
426	R:R:K103	R:R:Q106	4.07	No	No	0	6	7
427	R:R:K104	R:R:T386	1.5	No	No	0	6	6
428	R:R:L105	R:R:N110	9.61	Yes	Yes	3	8	9
429	R:R:L105	R:R:N384	4.12	Yes	Yes	3	8	9
430	R:R:L105	R:R:T386	5.9	Yes	No	3	8	6
431	R:R:L105	R:R:Y387	12.89	Yes	Yes	3	8	8
432	R:R:Q106	R:R:Y111	12.4	No	Yes	0	7	4
433	R:R:N107	R:R:N110	10.9	No	Yes	0	7	9
434	R:R:A108	R:R:A192	1.79	No	No	0	5	7
435	R:R:N110	R:R:T109	2.92	Yes	No	0	9	8
436	R:R:N110	R:R:Y387	5.81	Yes	Yes	3	9	8
437	R:R:M114	R:R:Y111	2.39	No	Yes	3	5	4
438	R:R:R189	R:R:Y111	20.58	Yes	Yes	3	4	4
439	R:R:A168	R:R:F112	2.77	No	Yes	1	7	8
440	R:R:F112	R:R:I169	12.56	Yes	No	0	8	9
441	R:R:D172	R:R:F112	7.17	No	Yes	1	9	8
442	R:R:F112	R:R:K195	16.13	Yes	Yes	1	8	6
443	R:R:F112	R:R:I196	6.28	Yes	No	0	8	8
444	R:R:L113	R:R:Y380	11.72	No	Yes	0	8	9
445	R:R:I118	R:R:M114	2.92	Yes	No	3	6	5
446	R:R:H165	R:R:S115	9.76	Yes	No	1	8	9
447	R:R:I196	R:R:S115	4.64	No	No	0	8	9
448	R:R:S115	R:R:W200	2.47	No	Yes	1	9	9
449	R:R:D120	R:R:L116	5.43	Yes	No	1	9	9
450	R:R:L116	R:R:S162	3	No	Yes	1	9	9
451	R:R:H165	R:R:L116	5.14	Yes	No	1	8	9
452	R:R:I118	R:R:M121	4.37	Yes	No	3	6	7
453	R:R:I118	R:R:L122	2.85	Yes	No	0	6	7
454	R:R:A119	R:R:A161	1.79	No	No	1	8	8
455	R:R:A119	R:R:S162	1.71	No	Yes	1	8	9
456	R:R:A119	R:R:W200	2.59	No	Yes	1	8	9
457	R:R:D120	R:R:S162	4.42	Yes	Yes	1	9	9
458	R:R:D120	R:R:S373	11.78	Yes	Yes	1	9	9
459	R:R:F158	R:R:L122	12.18	Yes	No	0	7	7
460	R:R:G124	R:R:L123	1.71	Yes	Yes	1	6	7
461	R:R:L123	R:R:V127	4.47	Yes	Yes	1	7	8
462	R:R:L123	R:R:M128	2.83	Yes	Yes	1	7	8
463	R:R:F158	R:R:L123	7.31	Yes	Yes	0	7	7
464	R:R:L123	R:R:S373	1.5	Yes	Yes	1	7	9
465	R:R:G124	R:R:M128	5.24	Yes	Yes	1	6	8
466	R:R:F125	R:R:L126	3.65	No	No	0	4	5
467	R:R:L126	R:R:L154	2.77	No	No	0	5	5
468	R:R:V127	R:R:W151	3.68	Yes	Yes	1	8	5
469	R:R:L154	R:R:V127	1.49	No	Yes	0	5	8
470	R:R:D155	R:R:V127	5.84	Yes	Yes	1	8	8
471	R:R:V127	R:R:Y370	3.79	Yes	Yes	1	8	7
472	R:R:M128	R:R:P129	1.68	Yes	No	1	8	8
473	R:R:M128	R:R:W367	2.33	Yes	Yes	1	8	6
474	R:R:M128	R:R:Y370	13.17	Yes	Yes	1	8	7
475	R:R:M128	R:R:S373	3.07	Yes	Yes	1	8	9
476	R:R:T134	R:R:V130	1.59	Yes	Yes	1	5	4
477	R:R:V130	R:R:W141	2.45	Yes	Yes	1	4	7
478	R:R:L143	R:R:V130	2.98	Yes	Yes	1	5	4
479	R:R:V130	R:R:W151	14.71	Yes	Yes	1	4	5
480	R:R:S131	R:R:W367	9.88	No	Yes	1	7	6
481	R:R:S131	R:R:Y370	2.54	No	Yes	1	7	7
482	R:R:M132	R:R:W367	2.33	Yes	Yes	1	6	6
483	R:R:L133	R:R:Y137	3.52	No	No	1	4	4
484	R:R:L133	R:R:P142	4.93	No	Yes	1	4	3
485	R:R:T134	R:R:Y139	4.99	Yes	Yes	0	5	3
486	R:R:T134	R:R:W141	2.43	Yes	Yes	1	5	7
487	R:R:P142	R:R:T134	1.75	Yes	Yes	1	3	5
488	R:R:I135	R:R:Y139	13.3	No	Yes	0	5	3
489	R:R:I135	R:R:W367	3.52	No	Yes	0	5	6
490	R:R:P142	R:R:Y137	9.74	Yes	No	1	3	4
491	R:R:N363	R:R:Y139	16.28	No	Yes	0	4	3
492	R:R:G225	R:R:R140	4.5	No	No	0	3	4
493	R:R:P142	R:R:W141	5.4	Yes	Yes	1	3	7
494	R:R:L143	R:R:W141	10.25	Yes	Yes	1	5	7
495	R:R:C148	R:R:W141	6.53	Yes	Yes	1	9	7
496	R:R:W141	R:R:W151	10.31	Yes	Yes	1	7	5
497	R:R:F222	R:R:W141	5.01	Yes	Yes	1	2	7
498	R:R:C227	R:R:W141	15.67	Yes	Yes	1	9	7
499	R:R:L143	R:R:P142	1.64	Yes	Yes	1	5	3
500	R:R:L143	R:R:P144	4.93	Yes	No	0	5	7
501	R:R:L147	R:R:P144	4.93	No	No	0	5	7
502	R:R:C148	R:R:V221	5.12	Yes	Yes	1	9	3
503	R:R:C148	R:R:F222	11.17	Yes	Yes	1	9	2
504	R:R:C148	R:R:C227	7.28	Yes	Yes	1	9	9
505	R:R:A149	R:R:I210	1.62	No	Yes	1	6	6
506	R:R:A149	R:R:G214	1.95	No	No	1	6	7
507	R:R:A149	R:R:V221	5.09	No	Yes	1	6	3
508	R:R:I152	R:R:W151	2.35	Yes	Yes	1	5	5
509	R:R:C227	R:R:W151	2.61	Yes	Yes	1	9	5
510	L:L:?1	R:R:W151	4.75	Yes	Yes	1	0	5
511	R:R:I152	R:R:V156	1.54	Yes	Yes	1	5	6
512	R:R:I152	R:R:I210	4.42	Yes	Yes	1	5	6
513	R:R:I152	R:R:V221	3.07	Yes	Yes	1	5	3
514	R:R:C227	R:R:I152	1.64	Yes	Yes	1	9	5
515	R:R:I152	R:R:L229	7.14	Yes	Yes	1	5	4
516	R:R:L154	R:R:Y153	3.52	No	Yes	0	5	6
517	R:R:L157	R:R:Y153	2.34	Yes	Yes	1	6	6
518	R:R:S207	R:R:Y153	7.63	Yes	Yes	1	7	6
519	R:R:I210	R:R:Y153	3.63	Yes	Yes	1	6	6
520	R:R:P211	R:R:Y153	4.17	No	Yes	1	5	6
521	R:R:D155	R:R:V156	4.38	Yes	Yes	1	8	6
522	R:R:D155	R:R:S159	4.42	Yes	No	1	8	7
523	R:R:D155	R:R:Y370	4.6	Yes	Yes	1	8	7
524	L:L:?1	R:R:D155	24.91	Yes	Yes	1	0	8
525	R:R:S207	R:R:V156	1.62	Yes	Yes	1	7	6
526	R:R:I210	R:R:V156	4.61	Yes	Yes	1	6	6
527	L:L:?1	R:R:V156	18.64	Yes	Yes	1	0	6
528	R:R:F158	R:R:L157	7.31	Yes	Yes	0	7	6
529	R:R:L157	R:R:S203	6.01	Yes	No	0	6	8
530	R:R:L157	R:R:V204	5.96	Yes	No	1	6	4
531	R:R:L157	R:R:S207	10.51	Yes	Yes	1	6	7
532	R:R:F158	R:R:W200	4.01	Yes	Yes	0	7	9
533	L:L:?1	R:R:S159	10.02	Yes	No	1	0	7
534	R:R:M164	R:R:T160	1.51	No	Yes	0	6	7
535	R:R:S203	R:R:T160	7.99	No	Yes	0	8	7
536	R:R:S242	R:R:T160	7.99	Yes	Yes	1	6	7
537	L:L:?1	R:R:T160	2.46	Yes	Yes	1	0	7
538	R:R:A161	R:R:W200	3.89	No	Yes	1	8	9
539	R:R:A161	R:R:S203	3.42	No	No	0	8	8
540	R:R:F332	R:R:S162	2.64	Yes	Yes	1	9	9
541	R:R:I163	R:R:L166	2.85	Yes	Yes	1	8	8
542	R:R:I163	R:R:P246	5.08	Yes	Yes	0	8	9
543	R:R:I163	R:R:M250	2.92	Yes	Yes	1	8	8
544	R:R:F332	R:R:I163	7.54	Yes	Yes	1	9	8
545	R:R:M164	R:R:V199	1.52	No	Yes	0	6	6
546	R:R:M164	R:R:P246	6.71	No	Yes	0	6	9
547	R:R:H165	R:R:V199	2.77	Yes	Yes	1	8	6
548	R:R:H165	R:R:W200	2.12	Yes	Yes	1	8	9
549	R:R:L166	R:R:M250	4.24	Yes	Yes	1	8	8
550	R:R:L166	R:R:V328	2.98	Yes	Yes	1	8	8
551	R:R:F329	R:R:L166	7.31	Yes	Yes	1	8	8
552	R:R:F332	R:R:L166	8.53	Yes	Yes	1	9	8
553	R:R:C167	R:R:P246	1.88	No	Yes	0	6	9
554	R:R:C167	R:R:I249	6.55	No	No	0	6	6
555	R:R:C167	R:R:M250	1.62	No	Yes	0	6	8
556	R:R:A168	R:R:K195	3.21	No	Yes	1	7	6
557	R:R:A168	R:R:V199	1.7	No	Yes	1	7	6
558	R:R:S170	R:R:T253	4.8	No	No	0	9	5
559	R:R:F329	R:R:S170	2.64	Yes	No	0	8	9
560	R:R:D172	R:R:K195	20.74	No	Yes	1	9	6
561	R:R:R173	R:R:T257	9.06	Yes	Yes	1	9	9
562	R:R:I258	R:R:R173	3.76	Yes	Yes	1	5	9
563	R:R:L261	R:R:R173	3.64	Yes	Yes	1	8	9
564	R:R:E318	R:R:R173	2.33	Yes	Yes	1	8	9
565	R:R:C322	R:R:R173	5.57	Yes	Yes	1	7	9
566	R:R:L325	R:R:R173	2.43	No	Yes	0	8	9
567	R:R:I177	R:R:Y174	6.04	No	No	1	9	8
568	R:R:L256	R:R:Y174	3.52	No	No	0	5	8
569	R:R:T257	R:R:Y174	8.74	Yes	No	1	9	8
570	R:R:I177	R:R:T257	6.08	No	Yes	1	9	9
571	R:R:I177	R:R:S260	1.55	No	No	0	9	6
572	R:R:K191	R:R:N187	9.79	No	No	0	6	6
573	R:R:R189	R:R:T190	2.59	Yes	Yes	3	4	5
574	R:R:F193	R:R:R189	2.14	No	Yes	0	4	4
575	R:R:K191	R:R:T190	1.5	No	Yes	0	6	5
576	R:R:F193	R:R:L194	2.44	No	No	0	4	3
577	R:R:F193	R:R:I197	5.02	No	No	0	4	2
578	R:R:K195	R:R:V199	1.52	Yes	Yes	1	6	6
579	R:R:I202	R:R:T201	1.52	No	No	0	5	4
580	R:R:I202	R:R:I206	2.94	No	No	0	5	6
581	R:R:S207	R:R:V204	4.85	Yes	No	1	7	4
582	R:R:I206	R:R:V241	3.07	No	No	0	6	4
583	R:R:M208	R:R:P209	1.68	No	No	1	4	7
584	R:R:M208	R:R:P211	1.68	No	No	1	4	5
585	R:R:F213	R:R:P209	4.33	No	No	0	4	7
586	R:R:I210	R:R:P211	3.39	Yes	No	1	6	5
587	R:R:F234	R:R:I210	7.54	Yes	Yes	1	7	6
588	R:R:G214	R:R:V221	3.68	No	Yes	1	7	3
589	R:R:S219	R:R:V221	1.62	No	Yes	0	3	3
590	R:R:D231	R:R:K220	15.21	No	No	0	5	3
591	R:R:C227	R:R:F222	4.19	Yes	Yes	1	9	2
592	R:R:K223	R:R:L228	5.64	No	No	0	3	4
593	R:R:A230	R:R:K223	3.21	No	No	0	3	3
594	R:R:E355	R:R:K223	2.7	No	No	0	3	3
595	R:R:L228	R:R:S226	4.5	No	No	0	4	4
596	L:L:?1	R:R:L228	2.31	Yes	No	0	0	4
597	R:R:F234	R:R:L229	6.09	Yes	Yes	1	7	4
598	R:R:L229	R:R:V235	2.98	Yes	No	0	4	6
599	L:L:?1	R:R:L229	5.77	Yes	Yes	1	0	4
600	R:R:D231	R:R:F234	2.39	No	Yes	0	5	7
601	R:R:D232	R:R:N233	2.69	No	No	0	4	3
602	R:R:D232	R:R:V347	4.38	No	Yes	7	4	5
603	R:R:D232	R:R:K350	9.68	No	No	7	4	1
604	R:R:F234	R:R:G238	4.52	Yes	Yes	1	7	6
605	L:L:?1	R:R:F234	2.03	Yes	Yes	1	0	7
606	R:R:N343	R:R:V235	5.91	Yes	No	0	7	6
607	R:R:V235	R:R:V347	4.81	No	Yes	0	6	5
608	R:R:I344	R:R:L236	2.85	No	No	0	5	6
609	R:R:L236	R:R:V347	4.47	No	Yes	0	6	5
610	R:R:I348	R:R:L236	2.85	No	No	0	4	6
611	R:R:G238	R:R:I237	3.53	Yes	No	0	6	4
612	R:R:I237	R:R:V241	1.54	No	No	0	4	4
613	R:R:G238	R:R:S242	1.86	Yes	Yes	1	6	6
614	L:L:?1	R:R:G238	4.28	Yes	Yes	1	0	6
615	R:R:F340	R:R:S239	7.93	Yes	Yes	1	7	6
616	R:R:N343	R:R:S239	2.98	Yes	Yes	1	7	6
617	R:R:I344	R:R:S239	3.1	No	Yes	0	5	6
618	L:L:?1	R:R:S239	8.77	Yes	Yes	1	0	6
619	R:R:F240	R:R:F244	10.72	No	Yes	0	4	5
620	R:R:F240	R:R:I344	5.02	No	No	0	4	5
621	R:R:S242	R:R:V241	1.62	Yes	No	0	6	4
622	L:L:?1	R:R:S242	5.01	Yes	Yes	1	0	6
623	R:R:F243	R:R:F244	12.86	Yes	Yes	1	8	5
624	R:R:A247	R:R:F243	5.55	No	Yes	1	6	8
625	R:R:F243	R:R:V333	2.62	Yes	Yes	1	8	6
626	R:R:F243	R:R:W336	3.01	Yes	Yes	1	8	8
627	R:R:F243	R:R:F340	21.43	Yes	Yes	1	8	7
628	R:R:F244	R:R:F340	2.14	Yes	Yes	1	5	7
629	R:R:F244	R:R:I341	5.02	Yes	No	0	5	6
630	R:R:I245	R:R:P246	3.39	No	Yes	0	5	9
631	R:R:A247	R:R:V333	1.7	No	Yes	1	6	6
632	R:R:I252	R:R:T248	3.04	No	No	0	5	3
633	R:R:I249	R:R:T253	1.52	No	No	0	6	5
634	R:R:M250	R:R:V251	1.52	Yes	No	0	8	5
635	R:R:M250	R:R:V333	3.04	Yes	Yes	1	8	6
636	R:R:I252	R:R:L256	2.85	No	No	0	5	5
637	R:R:F255	R:R:Y254	8.25	No	Yes	0	1	9
638	R:R:I258	R:R:Y254	9.67	Yes	Yes	1	5	9
639	R:R:G326	R:R:Y254	7.24	No	Yes	1	6	9
640	R:R:F329	R:R:Y254	6.19	Yes	Yes	1	8	9
641	R:R:I258	R:R:T257	1.52	Yes	Yes	1	5	9
642	R:R:L261	R:R:T257	2.95	Yes	Yes	1	8	9
643	R:R:I258	R:R:Q262	4.12	Yes	No	0	5	6
644	R:R:C322	R:R:I258	6.55	Yes	Yes	1	7	5
645	R:R:K259	R:R:Q262	8.14	No	No	0	4	6
646	R:R:E264	R:R:L261	2.65	No	Yes	0	7	8
647	R:R:E318	R:R:L261	13.25	Yes	Yes	1	8	8
648	R:R:C322	R:R:L261	1.59	Yes	Yes	1	7	8
649	R:R:A265	R:R:I315	1.62	No	Yes	0	5	5
650	R:R:I315	R:R:T311	1.52	Yes	No	0	5	4
651	R:R:K320	R:R:N317	6.99	No	No	0	8	6
652	R:R:E318	R:R:Q319	2.55	Yes	No	0	8	5
653	R:R:C322	R:R:E318	6.08	Yes	Yes	1	7	8
654	R:R:L325	R:R:V324	2.98	No	No	0	8	8
655	R:R:V324	R:R:V379	1.6	No	Yes	0	8	8
656	R:R:F329	R:R:L325	6.09	Yes	No	0	8	8
657	R:R:F329	R:R:G326	4.52	Yes	No	1	8	6
658	R:R:I327	R:R:V379	3.07	No	Yes	0	6	8
659	R:R:F329	R:R:V328	2.62	Yes	Yes	1	8	8
660	R:R:N376	R:R:V328	7.39	Yes	Yes	0	9	8
661	R:R:V328	R:R:V379	1.6	Yes	Yes	1	8	8
662	R:R:F330	R:R:L331	4.87	No	No	0	5	6
663	R:R:F330	R:R:V334	11.8	No	No	0	5	5
664	R:R:L331	R:R:V375	5.96	No	Yes	1	6	6
665	R:R:L331	R:R:V379	1.49	No	Yes	1	6	8
666	R:R:F332	R:R:W336	7.02	Yes	Yes	1	9	8
667	R:R:F332	R:R:S372	3.96	Yes	Yes	1	9	9
668	R:R:V333	R:R:V334	1.6	Yes	No	0	6	5
669	R:R:I368	R:R:M335	2.92	No	Yes	1	7	8
670	R:R:G369	R:R:M335	1.75	No	Yes	1	7	8
671	R:R:M335	R:R:S372	3.07	Yes	Yes	1	8	9
672	R:R:M335	R:R:V375	3.04	Yes	Yes	1	8	6
673	R:R:F339	R:R:W336	7.02	Yes	Yes	1	7	8
674	R:R:F340	R:R:W336	9.02	Yes	Yes	1	7	8
675	R:R:G369	R:R:W336	12.67	No	Yes	1	7	8
676	R:R:W336	R:R:Y370	3.86	Yes	Yes	1	8	7
677	R:R:S372	R:R:W336	4.94	Yes	Yes	1	9	8
678	L:L:?1	R:R:W336	2.85	Yes	Yes	1	0	8
679	R:R:C337	R:R:P338	1.88	No	No	0	6	9
680	R:R:F365	R:R:P338	10.11	Yes	No	0	5	9
681	R:R:F339	R:R:F340	12.86	Yes	Yes	1	7	7
682	R:R:F339	R:R:N343	13.29	Yes	Yes	1	7	7
683	R:R:F339	R:R:L362	3.65	Yes	Yes	1	7	3
684	R:R:F339	R:R:V366	6.55	Yes	Yes	1	7	6
685	L:L:?1	R:R:F339	14.22	Yes	Yes	1	0	7
686	L:L:?1	R:R:F340	10.16	Yes	Yes	1	0	7
687	R:R:I341	R:R:T342	1.52	No	Yes	0	6	5
688	R:R:I358	R:R:T342	1.52	Yes	Yes	0	4	5
689	R:R:L362	R:R:T342	2.95	Yes	Yes	0	3	5
690	R:R:F365	R:R:T342	3.89	Yes	Yes	0	5	5
691	R:R:A346	R:R:N343	1.56	No	Yes	0	4	7
692	R:R:L362	R:R:N343	4.12	Yes	Yes	1	3	7
693	L:L:?1	R:R:N343	5.73	Yes	Yes	1	0	7
694	R:R:C349	R:R:M345	1.62	No	No	0	3	4
695	R:R:A346	R:R:V347	1.7	No	Yes	0	4	5
696	R:R:A346	R:R:I358	1.62	No	Yes	0	4	4
697	R:R:K350	R:R:V347	7.59	No	Yes	7	1	5
698	R:R:C349	R:R:C353	7.28	No	No	0	3	3
699	R:R:C353	R:R:S352	1.72	No	No	0	3	2
700	R:R:C353	R:R:I358	1.64	No	Yes	0	3	4
701	R:R:D356	R:R:N354	4.04	No	No	0	2	1
702	R:R:N354	R:R:V357	5.91	No	No	0	1	5
703	R:R:E355	R:R:G359	4.91	No	No	0	3	2
704	R:R:L361	R:R:V357	1.49	No	No	0	4	5
705	R:R:G359	R:R:I358	1.76	No	Yes	0	2	4
706	R:R:G359	R:R:L362	1.71	No	Yes	0	2	3
707	R:R:F365	R:R:L361	9.74	Yes	No	0	5	4
708	R:R:F365	R:R:V364	3.93	Yes	No	0	5	4
709	R:R:F365	R:R:I368	3.77	Yes	No	0	5	7
710	R:R:V366	R:R:W367	3.68	Yes	Yes	1	6	6
711	R:R:V366	R:R:Y370	8.83	Yes	Yes	1	6	7
712	L:L:?1	R:R:V366	3.73	Yes	Yes	1	0	6
713	R:R:W367	R:R:Y370	12.54	Yes	Yes	1	6	7
714	R:R:G369	R:R:I368	1.76	No	No	1	7	7
715	L:L:?1	R:R:Y370	1.96	Yes	Yes	1	0	7
716	R:R:S372	R:R:S373	1.63	Yes	Yes	1	9	9
717	R:R:N376	R:R:V375	2.96	Yes	Yes	0	9	6
718	R:R:V375	R:R:V379	1.6	Yes	Yes	1	6	8
719	R:R:N376	R:R:P377	1.63	Yes	Yes	0	9	9
720	R:R:N376	R:R:Y380	4.65	Yes	Yes	0	9	9
721	R:R:Y380	R:R:Y387	17.87	Yes	Yes	3	9	8
722	R:R:R388	R:R:T381	5.17	No	No	0	9	7
723	R:R:F391	R:R:T381	5.19	Yes	No	0	6	7
724	R:R:F383	R:R:L382	9.74	No	No	0	7	5
725	R:R:N384	R:R:T386	2.92	Yes	No	3	9	6
726	R:R:N384	R:R:Y387	9.3	Yes	Yes	3	9	8
727	R:R:K385	R:R:R388	6.19	No	No	0	5	9
728	R:R:F391	R:R:Y387	4.13	Yes	Yes	3	6	8
729	R:R:A390	R:R:Y394	2.67	No	Yes	6	7	4
730	R:R:R393	R:R:Y394	12.35	No	Yes	6	4	4
731	R:R:R393	R:R:Y399	2.06	No	Yes	6	4	2
732	R:R:Y394	R:R:Y399	10.92	Yes	Yes	6	4	2
733	S:S:N179	S:S:V175	1.48	No	No	0	6	5
734	S:S:I202	S:S:I206	1.47	No	No	0	5	6
735	R:R:I89	R:R:I93	1.47	Yes	No	0	5	3
736	R:R:L378	R:R:T381	1.47	No	No	0	6	7
737	S:S:N187	S:S:T190	1.46	Yes	No	0	6	5
738	R:R:I93	R:R:M97	1.46	No	No	0	3	4
739	R:R:D172	R:R:V175	1.46	No	No	0	9	5
740	R:R:I315	R:R:M312	1.46	Yes	No	0	5	4
741	S:S:G138	S:S:Y139	1.45	No	Yes	0	5	3
742	R:R:I135	R:R:K74	1.45	No	No	0	5	6
743	R:R:G138	R:R:Y139	1.45	No	Yes	0	5	3
744	S:S:K259	S:S:K263	1.44	No	No	0	4	5
745	R:R:Q313	R:R:S314	1.44	No	No	0	5	5
746	S:S:I237	S:S:N233	1.42	No	No	0	4	3
747	R:R:G205	S:S:W76	1.41	No	No	0	4	4
748	R:R:K146	R:R:L147	1.41	No	No	0	1	5
749	S:S:K191	S:S:N187	1.4	No	Yes	0	6	6
750	R:R:K320	R:R:N384	1.4	No	Yes	0	8	9
751	S:S:A321	S:S:R173	1.38	No	Yes	0	8	9
752	R:R:L378	R:R:L382	1.38	No	No	0	6	5
753	S:S:L194	S:S:N187	1.37	No	Yes	0	3	6
754	R:R:L71	R:R:N75	1.37	No	No	0	3	5
755	R:R:I315	R:R:Q319	1.37	Yes	No	0	5	5
756	R:R:I395	R:R:Q396	1.37	No	No	0	6	4
757	R:R:K323	R:R:Q319	1.36	No	No	0	7	5
758	S:S:E102	S:S:K104	1.35	No	No	0	6	6
759	S:S:E355	S:S:K223	1.35	Yes	No	5	3	3
760	S:S:N75	S:S:Q72	1.32	Yes	No	0	5	1
761	S:S:R393	S:S:S392	1.32	No	No	0	4	3
762	R:R:F222	R:R:S145	1.32	Yes	No	0	2	3
763	R:R:N317	R:R:Q313	1.32	No	No	0	6	5
764	S:S:Q262	S:S:Q319	1.28	No	No	0	6	5
765	R:R:Q396	R:R:Q398	1.28	No	No	0	4	4
766	S:S:N75	S:S:W76	1.13	Yes	No	0	5	4
767	S:S:Q178	S:S:Y174	1.13	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	S:S:N75	3.35	4	1	5
2	S:S:V84	2.97	4	2	7
3	S:S:T88	2.66833	6	2	7
4	S:S:N92	5.106	5	2	9
5	S:S:L94	4.715	4	0	6
6	S:S:V95	3.694	5	2	9
7	S:S:I96	3.526	5	2	6
8	S:S:A98	2.83	5	2	7
9	S:S:L105	5.32	4	2	8
10	S:S:F112	4.774	5	4	8
11	S:S:L123	4.595	6	2	7
12	S:S:V127	5.478	5	2	8
13	S:S:M128	4.6275	8	2	8
14	S:S:V130	5.955	4	2	4
15	S:S:Y139	8.985	4	0	3
16	S:S:W141	8.2825	8	2	7
17	S:S:P142	6.856	5	2	3
18	S:S:L143	3.76	5	2	5
19	S:S:C148	6.4025	4	2	9
20	S:S:W151	9.03	6	2	5
21	S:S:Y153	4.805	4	2	6
22	S:S:D155	8.868	5	2	8
23	S:S:L157	4.0775	4	0	6
24	S:S:F158	7.38	5	0	7
25	S:S:T160	5.45	4	4	7
26	S:S:I163	4.72	4	0	8
27	S:S:M164	3.9175	4	4	6
28	S:S:H165	8.8475	4	4	8
29	S:S:L166	4.38	5	2	8
30	S:S:R173	4.038	5	0	9
31	S:S:Y174	4.334	5	0	8
32	S:S:I177	5.7375	4	0	9
33	S:S:N187	3.775	4	0	6
34	S:S:W200	4.98333	6	4	9
35	S:S:S203	3.58	4	4	8
36	S:S:I210	4.896	5	2	6
37	S:S:F213	6.6075	4	2	4
38	S:S:V221	3.125	4	2	3
39	S:S:F222	4.63	4	2	2
40	S:S:L229	5.55	5	2	4
41	S:S:F234	5.01833	6	2	7
42	S:S:F243	9.082	5	2	8
43	S:S:F244	5.102	5	2	5
44	S:S:P246	5.115	4	0	9
45	S:S:M250	4.172	5	2	8
46	S:S:Y254	9.6875	4	2	9
47	S:S:V324	2.608	5	2	8
48	S:S:V328	3.4525	4	2	8
49	S:S:F329	5.20714	7	2	8
50	S:S:F332	6.416	5	2	9
51	S:S:M335	2.81	5	0	8
52	S:S:W336	5.74889	9	2	8
53	S:S:F339	9.29167	6	2	7
54	S:S:F340	10.684	5	2	7
55	S:S:N343	4.828	5	2	7
56	S:S:I344	4.9475	4	0	5
57	S:S:V347	3.095	4	0	5
58	S:S:C349	3.495	4	5	3
59	S:S:E355	2.12	4	5	3
60	S:S:I358	3.915	4	5	4
61	S:S:L362	4.4925	4	2	3
62	S:S:F365	4.718	5	0	5
63	S:S:V366	5.4225	4	2	6
64	S:S:W367	7.87714	7	2	6
65	S:S:Y370	8.03	9	2	7
66	S:S:S372	5.1375	4	2	9
67	S:S:S373	3.646	5	2	9
68	S:S:N376	4.4175	4	0	9
69	S:S:P377	3.12	4	0	9
70	S:S:V379	3.5725	4	2	8
71	S:S:Y380	7.15	5	2	9
72	S:S:Y387	6.28625	8	2	8
73	S:S:F391	5.512	5	2	6
74	S:S:Y394	6.545	4	2	4
75	R:R:V84	2.8075	4	1	7
76	R:R:I85	3.766	5	1	6
77	R:R:T88	2.895	6	1	7
78	R:R:I89	2.7975	4	0	5
79	R:R:N92	6.7325	4	0	9
80	R:R:V95	3.926	5	3	9
81	R:R:L101	14.425	4	6	5
82	R:R:E102	7.91167	6	6	6
83	R:R:L105	8.13	4	3	8
84	R:R:N110	7.31	4	3	9
85	R:R:Y111	9.4725	4	3	4
86	R:R:F112	8.982	5	1	8
87	R:R:I118	6.215	4	3	6
88	R:R:D120	7.4275	4	1	9
89	R:R:L123	3.564	5	1	7
90	R:R:G124	2.6325	4	1	6
91	R:R:V127	3.854	5	1	8
92	R:R:M128	4.14333	9	1	8
93	R:R:V130	5.4325	4	1	4
94	R:R:M132	3.96	4	1	6
95	R:R:T134	2.69	4	1	5
96	R:R:Y139	9.005	4	0	3
97	R:R:W141	7.25625	8	1	7
98	R:R:P142	4.692	5	1	3
99	R:R:L143	4.95	4	1	5
100	R:R:C148	7.525	4	1	9
101	R:R:W151	6.40167	6	1	5
102	R:R:I152	3.36	6	1	5
103	R:R:Y153	4.258	5	1	6
104	R:R:D155	8.83	5	1	8
105	R:R:V156	6.158	5	1	6
106	R:R:L157	6.426	5	1	6
107	R:R:F158	7.7025	4	0	7
108	R:R:T160	4.9875	4	1	7
109	R:R:S162	2.9425	4	1	9
110	R:R:I163	4.5975	4	1	8
111	R:R:H165	4.9475	4	1	8
112	R:R:L166	5.182	5	1	8
113	R:R:R173	4.465	6	1	9
114	R:R:R189	8.08	4	3	4
115	R:R:T190	3.64	4	3	5
116	R:R:K195	10.4	4	1	6
117	R:R:V199	1.8775	4	1	6
118	R:R:W200	3.016	5	1	9
119	R:R:S207	6.1525	4	1	7
120	R:R:I210	4.20167	6	1	6
121	R:R:V221	3.716	5	1	3
122	R:R:F222	5.4225	4	1	2
123	R:R:C227	6.278	5	1	9
124	R:R:L229	5.495	4	1	4
125	R:R:F234	4.514	5	1	7
126	R:R:G238	3.5475	4	1	6
127	R:R:S239	5.695	4	1	6
128	R:R:S242	4.12	4	1	6
129	R:R:F243	9.094	5	1	8
130	R:R:F244	7.685	4	1	5
131	R:R:P246	4.265	4	0	9
132	R:R:M250	2.668	5	1	8
133	R:R:Y254	7.8375	4	1	9
134	R:R:T257	5.67	5	1	9
135	R:R:I258	5.124	5	1	5
136	R:R:L261	4.816	5	1	8
137	R:R:I315	1.4925	4	0	5
138	R:R:E318	6.0525	4	1	8
139	R:R:C322	4.9475	4	1	7
140	R:R:V328	3.6475	4	1	8
141	R:R:F329	4.895	6	1	8
142	R:R:F332	5.938	5	1	9
143	R:R:V333	2.24	4	1	6
144	R:R:M335	2.695	4	1	8
145	R:R:W336	6.29875	8	1	8
146	R:R:F339	9.59833	6	1	7
147	R:R:F340	10.59	6	1	7
148	R:R:T342	2.47	4	0	5
149	R:R:N343	5.59833	6	1	7
150	R:R:V347	4.59	5	7	5
151	R:R:I358	1.635	4	0	4
152	R:R:L362	3.1075	4	1	3
153	R:R:F365	6.288	5	0	5
154	R:R:V366	5.6975	4	1	6
155	R:R:W367	6.49667	9	1	6
156	R:R:Y370	6.41125	8	1	7
157	R:R:S372	3.4	4	1	9
158	R:R:S373	4.236	5	1	9
159	R:R:V375	3.39	4	1	6
160	R:R:N376	4.1575	4	0	9
161	R:R:P377	4.7475	4	0	9
162	R:R:V379	1.872	5	1	8
163	R:R:Y380	10.4525	4	3	9
164	R:R:N384	4.435	4	3	9
165	R:R:Y387	8.04429	7	3	8
166	R:R:F391	6.335	4	3	6
167	R:R:Y394	10.0057	7	6	4
168	R:R:Y399	11.1325	4	6	2
169	M:M:?1	8.40769	13	2	0
170	L:L:?1	7.50588	17	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:A82	S:S:L79	99.9332	4.73	No	No	0	3	4
2	R:R:V204	S:S:L79	100	1.49	No	No	0	4	4
3	R:R:L157	R:R:V204	43.6488	5.96	Yes	No	1	6	4
4	R:R:S207	R:R:V204	56.4165	4.85	Yes	No	1	7	4
5	S:S:A82	S:S:M132	99.8654	3.22	No	No	0	3	6
6	S:S:M132	S:S:T81	99.7967	12.04	No	No	0	6	6
7	S:S:T81	S:S:W367	99.727	10.92	No	Yes	0	6	6
8	S:S:M128	S:S:W367	21.1324	4.65	Yes	Yes	2	8	6
9	S:S:M128	S:S:S373	16.933	3.07	Yes	Yes	2	8	9
10	S:S:D120	S:S:S373	23.0288	8.83	No	Yes	0	9	9
11	S:S:D120	S:S:N376	17.0583	2.69	No	Yes	0	9	9
12	S:S:N376	S:S:Y380	15.1595	5.81	Yes	Yes	0	9	9
13	S:S:Y380	S:S:Y387	13.852	11.91	Yes	Yes	2	9	8
14	S:S:W367	S:S:Y370	60.0772	20.26	Yes	Yes	2	6	7
15	S:S:W336	S:S:Y370	31.6308	1.93	Yes	Yes	2	8	7
16	S:S:F332	S:S:W336	32.7691	8.02	Yes	Yes	2	9	8
17	S:S:F332	S:S:L166	31.5435	8.53	Yes	Yes	2	9	8
18	S:S:F329	S:S:L166	17.5434	4.87	Yes	Yes	2	8	8
19	M:M:?1	S:S:Y370	23.2896	2.93	Yes	Yes	2	0	7
20	S:S:S170	S:S:T253	15.2419	4.8	No	No	0	9	5
21	S:S:T253	S:S:Y174	14.4033	4.99	No	Yes	0	5	8
22	R:R:F158	R:R:L157	37.7553	7.31	Yes	Yes	0	7	6
23	R:R:F158	R:R:L122	20.952	12.18	Yes	No	0	7	7
24	R:R:I118	R:R:L122	20.4976	2.85	Yes	No	0	6	7
25	R:R:I118	R:R:M114	16.621	2.92	Yes	No	3	6	5
26	R:R:M114	R:R:Y111	10.1279	2.39	No	Yes	3	5	4
27	R:R:R189	R:R:Y111	10.7875	20.58	Yes	Yes	3	4	4
28	L:L:?1	R:R:V156	41.7231	18.64	Yes	Yes	1	0	6
29	R:R:F158	R:R:L123	22.7563	7.31	Yes	Yes	0	7	7
30	R:R:N92	R:R:T88	13.8793	4.39	Yes	Yes	0	9	7
31	R:R:N92	R:R:P377	12.3407	9.77	Yes	Yes	0	9	9
32	R:R:F332	R:R:L166	16.1106	8.53	Yes	Yes	1	9	8
33	R:R:F332	R:R:W336	16.1276	7.02	Yes	Yes	1	9	8
34	L:L:?1	R:R:W336	21.7432	2.85	Yes	Yes	1	0	8
35	R:R:F329	R:R:L166	12.9067	7.31	Yes	Yes	1	8	8
36	R:R:S207	R:R:V156	53.5242	1.62	Yes	Yes	1	7	6
37	R:R:I152	R:R:V156	10.2435	1.54	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:L123	S:S:V127	4.47	2	Yes	Yes	7	8	2	2
S:S:D155	S:S:L123	2.71	2	Yes	Yes	8	7	1	2
S:S:L123	S:S:S159	4.5	2	Yes	No	7	7	2	1
S:S:L123	S:S:Y370	5.86	2	Yes	Yes	7	7	2	1
S:S:V127	S:S:W151	6.13	2	Yes	Yes	8	5	2	1
S:S:D155	S:S:V127	8.76	2	Yes	Yes	8	8	1	2
S:S:V127	S:S:Y370	5.05	2	Yes	Yes	8	7	2	1
S:S:M128	S:S:W367	4.65	2	Yes	Yes	8	6	2	2
S:S:M128	S:S:Y370	11.97	2	Yes	Yes	8	7	2	1
S:S:V130	S:S:W141	3.68	2	Yes	Yes	4	7	2	2
S:S:V130	S:S:W151	17.16	2	Yes	Yes	4	5	2	1
S:S:S131	S:S:W151	4.94	2	No	Yes	7	5	2	1
S:S:S131	S:S:W367	7.41	2	No	Yes	7	6	2	2
S:S:S131	S:S:Y370	6.36	2	No	Yes	7	7	2	1
S:S:W141	S:S:W151	12.18	2	Yes	Yes	7	5	2	1
S:S:C227	S:S:W141	18.28	2	No	Yes	9	7	2	2
S:S:C227	S:S:W151	5.22	2	No	Yes	9	5	2	1
M:M:?1	S:S:W151	8.55	2	Yes	Yes	0	5	0	1
S:S:I152	S:S:L229	7.14	0	No	Yes	5	4	2	1
S:S:D155	S:S:S159	4.42	2	Yes	No	8	7	1	1
S:S:D155	S:S:Y370	10.34	2	Yes	Yes	8	7	1	1
M:M:?1	S:S:D155	18.11	2	Yes	Yes	0	8	0	1
S:S:S207	S:S:V156	4.85	0	No	No	7	6	2	1
S:S:I210	S:S:V156	4.61	2	Yes	No	6	6	2	1
M:M:?1	S:S:V156	17.4	2	Yes	No	0	6	0	1
M:M:?1	S:S:S159	3.76	2	Yes	No	0	7	0	1
S:S:S242	S:S:T160	6.4	0	No	Yes	6	7	1	2
S:S:F234	S:S:P209	4.33	2	Yes	No	7	7	1	2
S:S:I210	S:S:L229	2.85	2	Yes	Yes	6	4	2	1
S:S:F234	S:S:I210	8.79	2	Yes	Yes	7	6	1	2
S:S:D231	S:S:F213	11.94	2	No	Yes	5	4	2	2
S:S:F213	S:S:F234	4.29	2	Yes	Yes	4	7	2	1
S:S:F234	S:S:L229	4.87	2	Yes	Yes	7	4	1	1
S:S:L229	S:S:V235	5.96	2	Yes	No	4	6	1	2
M:M:?1	S:S:L229	6.93	2	Yes	Yes	0	4	0	1
S:S:D231	S:S:F234	4.78	2	No	Yes	5	7	2	1
M:M:?1	S:S:F234	3.05	2	Yes	Yes	0	7	0	1
S:S:N343	S:S:V235	5.91	2	Yes	No	7	6	1	2
S:S:G238	S:S:S242	1.86	0	No	No	6	6	2	1
S:S:F244	S:S:S239	2.64	2	Yes	No	5	6	2	2
S:S:N343	S:S:S239	4.47	2	Yes	No	7	6	1	2
M:M:?1	S:S:S242	6.26	2	Yes	No	0	6	0	1
S:S:F243	S:S:F244	10.72	2	Yes	Yes	8	5	2	2
S:S:F243	S:S:W336	3.01	2	Yes	Yes	8	8	2	1
S:S:F243	S:S:F340	23.58	2	Yes	Yes	8	7	2	1
S:S:F244	S:S:F340	2.14	2	Yes	Yes	5	7	2	1
S:S:F332	S:S:W336	8.02	2	Yes	Yes	9	8	2	1
S:S:F332	S:S:S372	6.61	2	Yes	Yes	9	9	2	2
S:S:F339	S:S:W336	7.02	2	Yes	Yes	7	8	1	1
S:S:F340	S:S:W336	9.02	2	Yes	Yes	7	8	1	1
S:S:V366	S:S:W336	2.45	2	Yes	Yes	6	8	1	1
S:S:G369	S:S:W336	11.26	0	No	Yes	7	8	2	1
S:S:W336	S:S:Y370	1.93	2	Yes	Yes	8	7	1	1
S:S:S372	S:S:W336	6.18	2	Yes	Yes	9	8	2	1
M:M:?1	S:S:W336	2.85	2	Yes	Yes	0	8	0	1
S:S:F339	S:S:F340	7.5	2	Yes	Yes	7	7	1	1
S:S:F339	S:S:N343	4.83	2	Yes	Yes	7	7	1	1
S:S:F339	S:S:L362	4.87	2	Yes	Yes	7	3	1	2
S:S:F339	S:S:V366	9.18	2	Yes	Yes	7	6	1	1
M:M:?1	S:S:F339	22.35	2	Yes	Yes	0	7	0	1
M:M:?1	S:S:F340	11.18	2	Yes	Yes	0	7	0	1
S:S:L362	S:S:N343	5.49	2	Yes	Yes	3	7	2	1
M:M:?1	S:S:N343	3.44	2	Yes	Yes	0	7	0	1
S:S:V366	S:S:Y370	7.57	2	Yes	Yes	6	7	1	1
M:M:?1	S:S:V366	2.49	2	Yes	Yes	0	6	0	1
S:S:W367	S:S:Y370	20.26	2	Yes	Yes	6	7	2	1
M:M:?1	S:S:Y370	2.93	2	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V127	R:R:W151	3.68	1	Yes	Yes	8	5	2	1
R:R:D155	R:R:V127	5.84	1	Yes	Yes	8	8	1	2
R:R:V127	R:R:Y370	3.79	1	Yes	Yes	8	7	2	1
R:R:M128	R:R:W367	2.33	1	Yes	Yes	8	6	2	2
R:R:M128	R:R:Y370	13.17	1	Yes	Yes	8	7	2	1
R:R:V130	R:R:W141	2.45	1	Yes	Yes	4	7	2	2
R:R:V130	R:R:W151	14.71	1	Yes	Yes	4	5	2	1
R:R:S131	R:R:W367	9.88	1	No	Yes	7	6	2	2
R:R:S131	R:R:Y370	2.54	1	No	Yes	7	7	2	1
R:R:W141	R:R:W151	10.31	1	Yes	Yes	7	5	2	1
R:R:C227	R:R:W141	15.67	1	Yes	Yes	9	7	2	2
R:R:I152	R:R:W151	2.35	1	Yes	Yes	5	5	2	1
R:R:C227	R:R:W151	2.61	1	Yes	Yes	9	5	2	1
L:L:?1	R:R:W151	4.75	1	Yes	Yes	0	5	0	1
R:R:I152	R:R:V156	1.54	1	Yes	Yes	5	6	2	1
R:R:I152	R:R:I210	4.42	1	Yes	Yes	5	6	2	2
R:R:C227	R:R:I152	1.64	1	Yes	Yes	9	5	2	2
R:R:I152	R:R:L229	7.14	1	Yes	Yes	5	4	2	1
R:R:D155	R:R:V156	4.38	1	Yes	Yes	8	6	1	1
R:R:D155	R:R:S159	4.42	1	Yes	No	8	7	1	1
R:R:D155	R:R:Y370	4.6	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:D155	24.91	1	Yes	Yes	0	8	0	1
R:R:S207	R:R:V156	1.62	1	Yes	Yes	7	6	2	1
R:R:I210	R:R:V156	4.61	1	Yes	Yes	6	6	2	1
L:L:?1	R:R:V156	18.64	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S159	10.02	1	Yes	No	0	7	0	1
R:R:M164	R:R:T160	1.51	0	No	Yes	6	7	2	1
R:R:S203	R:R:T160	7.99	0	No	Yes	8	7	2	1
R:R:S242	R:R:T160	7.99	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:T160	2.46	1	Yes	Yes	0	7	0	1
R:R:F234	R:R:I210	7.54	1	Yes	Yes	7	6	1	2
R:R:K223	R:R:L228	5.64	0	No	No	3	4	2	1
R:R:L228	R:R:S226	4.5	0	No	No	4	4	1	2
L:L:?1	R:R:L228	2.31	1	Yes	No	0	4	0	1
R:R:F234	R:R:L229	6.09	1	Yes	Yes	7	4	1	1
R:R:L229	R:R:V235	2.98	1	Yes	No	4	6	1	2
L:L:?1	R:R:L229	5.77	1	Yes	Yes	0	4	0	1
R:R:D231	R:R:F234	2.39	0	No	Yes	5	7	2	1
R:R:F234	R:R:G238	4.52	1	Yes	Yes	7	6	1	1
L:L:?1	R:R:F234	2.03	1	Yes	Yes	0	7	0	1
R:R:N343	R:R:V235	5.91	1	Yes	No	7	6	1	2
R:R:G238	R:R:I237	3.53	1	Yes	No	6	4	1	2
R:R:I237	R:R:V241	1.54	0	No	No	4	4	2	2
R:R:G238	R:R:S242	1.86	1	Yes	Yes	6	6	1	1
L:L:?1	R:R:G238	4.28	1	Yes	Yes	0	6	0	1
R:R:F340	R:R:S239	7.93	1	Yes	Yes	7	6	1	1
R:R:N343	R:R:S239	2.98	1	Yes	Yes	7	6	1	1
R:R:I344	R:R:S239	3.1	0	No	Yes	5	6	2	1
L:L:?1	R:R:S239	8.77	1	Yes	Yes	0	6	0	1
R:R:S242	R:R:V241	1.62	1	Yes	No	6	4	1	2
L:L:?1	R:R:S242	5.01	1	Yes	Yes	0	6	0	1
R:R:F243	R:R:F244	12.86	1	Yes	Yes	8	5	2	2
R:R:F243	R:R:W336	3.01	1	Yes	Yes	8	8	2	1
R:R:F243	R:R:F340	21.43	1	Yes	Yes	8	7	2	1
R:R:F244	R:R:F340	2.14	1	Yes	Yes	5	7	2	1
R:R:F332	R:R:W336	7.02	1	Yes	Yes	9	8	2	1
R:R:F332	R:R:S372	3.96	1	Yes	Yes	9	9	2	2
R:R:F339	R:R:W336	7.02	1	Yes	Yes	7	8	1	1
R:R:F340	R:R:W336	9.02	1	Yes	Yes	7	8	1	1
R:R:G369	R:R:W336	12.67	1	No	Yes	7	8	2	1
R:R:W336	R:R:Y370	3.86	1	Yes	Yes	8	7	1	1
R:R:S372	R:R:W336	4.94	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:W336	2.85	1	Yes	Yes	0	8	0	1
R:R:F339	R:R:F340	12.86	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:N343	13.29	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:L362	3.65	1	Yes	Yes	7	3	1	2
R:R:F339	R:R:V366	6.55	1	Yes	Yes	7	6	1	1
L:L:?1	R:R:F339	14.22	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	10.16	1	Yes	Yes	0	7	0	1
R:R:A346	R:R:N343	1.56	0	No	Yes	4	7	2	1
R:R:L362	R:R:N343	4.12	1	Yes	Yes	3	7	2	1
L:L:?1	R:R:N343	5.73	1	Yes	Yes	0	7	0	1
R:R:V366	R:R:W367	3.68	1	Yes	Yes	6	6	1	2
R:R:V366	R:R:Y370	8.83	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:V366	3.73	1	Yes	Yes	0	6	0	1
R:R:W367	R:R:Y370	12.54	1	Yes	Yes	6	7	2	1
L:L:?1	R:R:Y370	1.96	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6WGT_poly
Class	A
SubFamily	Amine
Type	5-Hydroxytryptamine
SubType	5-HT2A
Species	Homo sapiens
Ligand	LSD
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.4
Date	2020-09-23
D.O.I.	10.1016/j.cell.2020.08.024

Net Summary
I_min	1.49
Number of Linked Nodes	517
Number of Links	767
Number of Hubs	170
Number of Links mediated by Hubs	574
Number of Communities	7
Number of Nodes involved in Communities	210
Number of Links involved in Communities	372

Path Summary
Number Of Nodes in MetaPath	38
Number Of Links MetaPath	37
Number of Shortest Paths	404766
Length Of Smallest Path	3
Average Path Length	14.8417
Length of Longest Path	34
Minimum Path Strength	1.225
Average Path Strength	5.75322
Maximum Path Strength	20.23
Minimum Path Correlation	0.7
Average Path Correlation	0.970001
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	62.2086
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	60.032
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7LD
PDB Residues	M:M:?1 L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7LD
Name	Lysergic acid diethylamide
Synonyms	D-lysergic acid diethylamide
Identifier	(6~{a}~{R},9~{R})-~{N},~{N}-diethyl-7-methyl-6,6~{a},8,9-tetrahydro-4~{H}-indolo[4,3-fg]quinoline-9-carboxamide
Formula	C20 H25 N3 O
Molecular Weight	323.432
SMILES	CCN(CC)C(=O)[C@H]1CN([C@@H]2Cc3c[nH]c4c3c(ccc4)C2=C1)C
PubChem	5761
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>6WGT_poly_Chain_R H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q S K V F K E G S C L L A D D N F V L I G S F V S F F I P A T I M V I T Y F L T I K S L Q K E A T M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C K E S C N E D V I G A L L N V F V W I G Y A S S A V N P L V Y T L F N K T Y R S A F S R Y I Q C Q Y K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	10.1038/s41594-018-0180-z
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.36	2020-09-23	10.1016/j.cell.2020.08.024
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.45	2022-07-06	10.1038/s41586-022-05258-z
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	10.1038/s41593-021-00971-w
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	10.1126/science.abl8615
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	To be published
	6WGT (Dimer)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WH4 (Dimer)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6WGT_poly.zip

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