Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N843 4.84254168
2R:R:F844 4.022519
3R:R:I872 3.29519
4R:R:T885 5.72254109
5R:R:F886 3.7925409
6R:R:I899 3.962549
7R:R:H900 5.71449
8R:R:F914 3.34418
9R:R:F930 3.1675405
10R:R:H935 4.5125419
11R:R:F936 4.4975407
12R:R:L939 3.286519
13R:R:F942 5.2625409
14R:R:W944 7.98649
15R:R:E948 7.87449
16R:R:G949 2.3925446
17R:R:Q951 3.175408
18R:R:F960 5.69409
19R:R:R966 4.9575409
20R:R:P978 2.286509
21R:R:S992 4.3975418
22R:R:Y993 3.61167619
23R:R:W1000 7.5425418
24R:R:L1001 5.7418
25R:R:F1007 2.462518
26R:R:I1008 3.3875417
27R:R:F1011 3.668519
28R:R:N1022 3.11448
29R:R:H1036 3.7875405
30R:R:L1040 4.28254206
31R:R:N1049 5.14254196
32R:R:W1053 6.29507
33R:R:L1063 7.2325449
34R:R:L1066 2.46408
35R:R:W1068 9.43419
36R:R:Y1074 6.6054177
37R:R:Y1084 5.49408
38R:R:F1086 6.66519
39R:R:F1098 5.546506
40R:R:C1102 4.14109
41R:R:Y1112 4.8865105
42A:A:L53 4.108559
43A:A:L54 3.91409
44A:A:N58 6.00754219
45A:A:S59 3.8575459
46A:A:K61 4.8125459
47A:A:F64 3.0575407
48A:A:Y209 3.53507
49A:A:F211 4.515408
50A:A:P217 3.926504
51A:A:F218 4.4375407
52A:A:M220 4.36408
53A:A:E229 5.91754149
54A:A:F237 3.3225409
55A:A:S242 3.49508
56A:A:L244 3.375458
57A:A:F245 3.8275409
58A:A:L246 3.246557
59A:A:V276 2.775406
60A:A:V280 4.4554155
61A:A:I287 3.165459
62A:A:F289 3.724559
63A:A:F312 4.976676245
64A:A:L319 3.894503
65A:A:D321 4.424245
66A:A:F325 4.53406
67A:A:P341 5.3575405
68A:A:F346 9.1775405
69B:B:D5 6.44401
70B:B:R8 4.28403
71B:B:Q17 3.8275404
72B:B:L30 4.4475405
73B:B:I37 3.475402
74B:B:V40 2.74754253
75B:B:M45 3.37404
76B:B:R52 6.2025407
77B:B:H54 5.468509
78B:B:W63 5.455687
79B:B:I80 6.66478
80B:B:W82 7.90667679
81B:B:D83 4.86754268
82B:B:K89 7.0875479
83B:B:W99 5.744509
84B:B:Y105 2.496506
85B:B:Y111 4.965404
86B:B:A113 2.29754279
87B:B:L117 4.0575409
88B:B:I123 2.7506
89B:B:Y124 4.3375406
90B:B:H142 6.015119
91B:B:Y145 3.1045148
92B:B:C148 2.6975426
93B:B:N155 3.7325403
94B:B:I157 2.8407
95B:B:T159 4.35119
96B:B:S160 3.188526
97B:B:S161 5.4575409
98B:B:D163 6.7575409
99B:B:C166 3.035428
100B:B:A167 2.93754114
101B:B:W169 6.826676118
102B:B:F180 5.194527
103B:B:H183 5.65429
104B:B:D186 3.3885149
105B:B:L190 4.5625425
106B:B:L192 3.9775405
107B:B:R197 8.184525
108B:B:L198 2.88423
109B:B:F199 5.29629
110B:B:S201 3.465409
111B:B:C204 3.6325407
112B:B:K209 9.78426
113B:B:W211 5.66167628
114B:B:E215 4.624523
115B:B:F222 5.014538
116B:B:H225 6.07333639
117B:B:I232 5.025408
118B:B:F235 7.7825126
119B:B:N237 6.23254125
120B:B:F241 5.086536
121B:B:S245 5.155439
122B:B:D247 7.626539
123B:B:L255 2.592536
124B:B:Y264 2.95605
125B:B:I273 3.152596
126B:B:R283 4.5725409
127B:B:Y289 4.392597
128B:B:W297 4.882598
129B:B:H311 7.856569
130B:B:C317 2.975407
131B:B:T321 6.552587
132B:B:D323 6.6425487
133B:B:G324 2.7425489
134B:B:M325 2.554505
135B:B:W332 11.755229
136B:B:L336 3.304577
137B:B:K337 5.888566
138B:B:W339 6.466569
139G:G:V30 2.55408
140G:G:Y40 6.19754126
141G:G:D48 5.528509
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:T1087 R:R:T868 11.13423.14NoNo088
2R:R:L864 R:R:T1087 10.28434.42NoNo078
3R:R:I872 R:R:T868 11.3843.04YesNo198
4R:R:I872 R:R:L876 26.09612.85YesNo099
5R:R:G1094 R:R:S875 11.16243.71NoNo089
6R:R:F908 R:R:L879 18.7572.44NoNo089
7R:R:F908 R:R:L876 17.73823.65NoNo089
8R:R:G1094 R:R:I1097 20.99091.76NoNo088
9R:R:C882 R:R:F886 11.2144.19NoYes069
10R:R:F886 R:R:H900 16.23142.26YesYes099
11R:R:H900 R:R:L1063 25.19393.86YesYes499
12R:R:I1097 R:R:L1063 22.22022.85NoYes089
13B:B:L318 B:B:S277 10.31743NoNo065
14B:B:S277 B:B:V320 10.58774.85NoNo057
15B:B:G319 B:B:V320 10.86191.84NoNo057
16B:B:G319 B:B:M61 11.14021.75NoNo056
17B:B:C317 B:B:M61 38.3934.86YesNo076
18B:B:C317 B:B:S316 46.60413.44YesNo079
19B:B:S316 B:B:W332 46.7863.71NoYes099
20B:B:K57 B:B:W332 46.720919.73NoYes2299
21A:A:D238 B:B:K57 46.95368.3NoNo089
22A:A:D238 A:A:S239 46.90542.94NoNo086
23A:A:K50 A:A:S239 47.0436.12NoNo096
24A:A:K50 A:A:L48 1004.23NoNo096
25A:A:L48 A:A:P217 99.91581.64NoYes064
26A:A:P217 A:A:V216 99.22343.53YesNo044
27A:A:V216 R:R:F960 88.08536.55NoYes049
28A:A:I366 R:R:F960 95.99762.51NoYes089
29A:A:I366 A:A:N370 95.5974.25NoNo088
30A:A:N370 R:R:M955 95.43045.61NoNo088
31A:A:L374 R:R:M955 95.26331.41NoNo058
32A:A:L374 R:R:R896 94.75873.64NoNo059
33R:R:H900 R:R:R896 70.58045.64YesNo099
34R:R:I899 R:R:W944 21.40685.87YesYes499
35R:R:I899 R:R:Q951 22.59312.74YesYes098
36R:R:E948 R:R:G949 31.37291.64YesYes496
37R:R:G949 R:R:N1022 30.03091.7YesYes468
38R:R:I1018 R:R:N1022 23.69072.83NoYes058
39R:R:F942 R:R:I1018 22.42622.51YesNo095
40R:R:G974 R:R:T943 12.78953.64NoNo095
41R:R:P978 R:R:T943 12.54051.75YesNo095
42R:R:G974 R:R:W944 13.02844.22NoYes099
43R:R:F1007 R:R:S992 12.06911.32YesYes188
44A:A:I287 A:A:S242 11.20523.1YesYes098
45A:A:S242 A:A:T241 15.43593.2YesNo088
46A:A:T241 A:A:V49 15.80984.76NoNo086
47A:A:F218 A:A:V49 16.2123.93YesNo076
48A:A:F218 A:A:V216 29.02635.24YesNo074
49B:B:D83 B:B:Y85 10.5192.3YesNo2684
50B:B:S84 B:B:Y85 11.46742.54NoNo054
51B:B:S84 B:B:W63 11.86183.71NoYes057
52B:B:M61 B:B:W63 28.95923.49NoYes067
53B:B:C114 B:B:L95 11.20963.17NoNo088
54B:B:C114 B:B:G115 16.77633.92NoNo089
55B:B:G115 B:B:T102 11.97511.82NoNo098
56B:B:C149 B:B:T102 12.50313.38NoNo088
57B:B:C149 B:B:T159 13.19661.69NoYes089
58B:B:H142 B:B:S161 19.43112.55YesYes099
59B:B:G162 B:B:S161 28.44791.86NoYes099
60B:B:G162 B:B:Y145 28.45752.9NoYes1498
61B:B:L117 B:B:Y145 42.00083.52YesYes098
62B:B:L117 B:B:W99 43.60994.56YesYes099
63A:A:V221 B:B:W99 38.00693.68NoYes069
64A:A:K219 A:A:V221 53.61933.04NoNo066
65A:A:K219 A:A:K50 53.64887.18NoNo069
66A:A:W233 B:B:M188 10.21332.33NoNo098
67B:B:C204 B:B:M188 10.47473.24YesNo078
68B:B:C204 B:B:D186 12.33213.11YesYes079
69B:B:D186 B:B:Y145 12.64593.45YesYes1498
70A:A:F211 A:A:M220 17.10024.98YesYes088
71A:A:F211 A:A:F218 21.0724.29YesYes087
72A:A:L52 A:A:V221 15.97672.98NoNo096
73A:A:F237 A:A:L52 15.88314.87YesNo099
74A:A:F237 B:B:W99 33.60063.01YesYes099
75A:A:L53 A:A:M220 13.93584.24YesYes098
76A:A:I243 A:A:L54 23.39712.85NoYes089
77A:A:F281 A:A:I243 45.92868.79NoNo098
78A:A:F281 A:A:V284 47.75153.93NoNo097
79A:A:V240 A:A:V284 48.11451.6NoNo097
80A:A:F237 A:A:V240 48.4772.62YesNo099
81A:A:F245 A:A:L54 20.31514.87YesYes099
82A:A:I243 A:A:I286 22.20855.89NoNo087
83A:A:F245 A:A:L288 18.07092.44YesNo099
84A:A:F312 A:A:V322 21.00622.62YesNo057
85A:A:L319 A:A:V322 21.80722.98YesNo037
86A:A:L319 A:A:Q323 26.6023.99YesNo035
87A:A:F346 A:A:Q323 27.399316.4YesNo055
88A:A:F346 A:A:V327 31.37812.62YesNo055
89A:A:H344 A:A:V327 32.17239.69NoNo055
90A:A:H344 A:A:L288 16.61152.57NoNo059
91A:A:H344 A:A:R331 16.36724.51NoNo053
92A:A:L342 A:A:R331 16.75277.29NoNo063
93A:A:I286 A:A:L342 17.1434.28NoNo076
94B:B:D258 B:B:F222 10.69524.78NoYes378
95B:B:F222 B:B:F241 11.27154.29YesYes386
96B:B:F241 B:B:I232 20.28156.28YesYes068
97B:B:I232 B:B:T243 21.62143.04YesNo088
98B:B:G244 B:B:T243 24.30023.64NoNo058
99B:B:G244 B:B:I273 23.27921.76NoYes956
100B:B:I273 B:B:Y289 24.07276.04YesYes967
101B:B:D291 B:B:Y289 31.43073.45NoYes087
102B:B:C271 B:B:D291 32.4623.11NoNo058
103B:B:C271 B:B:D290 32.65927.78NoNo056
104B:B:D290 B:B:R314 33.608913.1NoNo068
105B:B:R314 B:B:W332 33.994419.99NoYes089
106B:B:G324 B:B:T321 16.53791.82YesYes897
107B:B:T321 B:B:W63 18.767410.92YesYes877
108B:B:Q75 B:B:W99 29.6715.48NoYes099
109B:B:H142 B:B:W169 10.62246.35YesYes1198
110R:R:Q951 R:R:R896 24.33653.5YesNo089
111R:R:E948 R:R:H900 30.787811.08YesYes499
112R:R:F1011 R:R:F942 16.65455.36YesYes099
113B:B:Q75 B:B:Y59 29.459612.4NoNo098
114B:B:W332 B:B:Y59 29.32072.89YesNo2298
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7SF7
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRL3
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi2-G13)/Beta1/Gamma2
PDB Resolution 2.9
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04575-7
Net Summary
Imin 1.62
Number of Linked Nodes 824
Number of Links 975
Number of Hubs 141
Number of Links mediated by Hubs 511
Number of Communities 30
Number of Nodes involved in Communities 184
Number of Links involved in Communities 242
Path Summary
Number Of Nodes in MetaPath 115
Number Of Links MetaPath 114
Number of Shortest Paths 725603
Length Of Smallest Path 3
Average Path Length 26.5708
Length of Longest Path 54
Minimum Path Strength 1.295
Average Path Strength 4.62369
Maximum Path Strength 19.86
Minimum Path Correlation 0.7
Average Path Correlation 0.976484
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 47.6103
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.9193
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9HAR2
Sequence
>7SF7_Chain_R
TNFAVLMAH VEVKHSDAV HDLLLDVIT WVGILLSLV CLLICIFTF 
CFFRGLQSD RNTIHKNLC ISLFVAELL FLIGINRTD QPIACAVFA 
ALLHFFFLA AFTWMFLEG VQLYIMLVE VFESEHSRR KYFYLVGYG 
MPALIVAVS AAVDYRSYG TDKVCWLRL DTYFIWSFI GPATLIIML 
NVIFLGIAL YKMFHHTAI LKPESGCLD NIKSWVIGA IALLCLLGL 
TWAFGLMYI NESTVIMAY LFTIFNSLQ GMFIFIFHC VLQKKVRKE 
YGKCL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>7SF7_Chain_A
EDKAAAERS KEIDKCLSR EKTYVKRLV KILLLGADN SGKSTFLKQ 
MRIIKGIHE YDFEIKNVP FKMVDVGGQ RSERKRWFE CFDSVTSIL 
FLVDSSDFN RLTESLNDF ETIVNNRVF SNVSIILFL NKTDLLEEK 
VQIVSIKDY FLEFEGDPH CLRDVQKFL VECFRNKRR DQQQKPLYH 
HFTTAINTE NARLIFRDV KDTILHDNL KQLMLQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7SF7_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7SF7_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SF7B2AdhesionAdhesionADGRL3Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;22.92022-04-2710.1038/s41586-022-04575-7
7WY5B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WY8B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WYBB2AdhesionAdhesionADGRL3Mus musculus--Gi1/&β;1/&γ;22.972022-10-2610.1016/j.molcel.2022.10.009
7X10B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-G12)/&β;1/&γ;22.932022-10-2610.1016/j.molcel.2022.10.009
8JMTB2AdhesionAdhesionADGRL3Homo sapiens---3.32023-09-0610.1038/s41589-023-01389-0




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7SF7.zip



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