Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L53 4.108559
2A:A:L54 3.91409
3A:A:N58 6.00754169
4A:A:S59 3.8575459
5A:A:K61 4.8125459
6A:A:F64 3.0575407
7A:A:Y209 3.53507
8A:A:F211 4.515408
9A:A:P217 3.926504
10A:A:F218 4.4375407
11A:A:M220 4.36408
12A:A:E229 5.91754149
13A:A:F237 3.3225409
14A:A:S242 3.49508
15A:A:L244 3.375458
16A:A:F245 3.8275409
17A:A:L246 3.246557
18A:A:V276 2.775406
19A:A:V280 4.60754185
20A:A:I287 3.165459
21A:A:F289 3.724559
22A:A:F312 3.976676205
23A:A:L319 3.894503
24A:A:F325 4.53406
25A:A:P341 5.65155
26A:A:F346 9.1775405
27A:A:F359 6.14179
28A:A:H368 4.22254156
29B:B:Q17 3.8275404
30B:B:L30 4.4475405
31B:B:I37 3.475402
32B:B:V40 2.7475403
33B:B:M45 3.37404
34B:B:R52 6.2025407
35B:B:H54 5.468509
36B:B:W63 5.455687
37B:B:I80 6.66478
38B:B:W82 7.90667679
39B:B:D83 4.86754238
40B:B:K89 7.0875479
41B:B:W99 5.744509
42B:B:Y105 2.496506
43B:B:Y111 4.965404
44B:B:L117 4.0575409
45B:B:I123 2.97406
46B:B:Y124 4.3375406
47B:B:H142 6.015109
48B:B:Y145 3.1045148
49B:B:N155 3.7325403
50B:B:T159 4.35109
51B:B:S160 2.862526
52B:B:S161 5.4575409
53B:B:D163 6.7575409
54B:B:C166 3.035428
55B:B:A167 2.93754104
56B:B:W169 6.826676108
57B:B:F180 5.194527
58B:B:H183 5.65429
59B:B:D186 3.3885149
60B:B:L190 4.5625425
61B:B:L192 3.9775405
62B:B:R197 8.184525
63B:B:L198 2.88423
64B:B:F199 5.29629
65B:B:S201 3.465409
66B:B:C204 3.6325407
67B:B:K209 8.366526
68B:B:W211 5.66167628
69B:B:E215 4.624523
70B:B:F222 5.014538
71B:B:H225 6.07333639
72B:B:I232 5.025408
73B:B:F235 7.7825116
74B:B:N237 6.0645115
75B:B:F241 5.086536
76B:B:D247 7.626539
77B:B:L255 2.592536
78B:B:Y264 2.95605
79B:B:I273 3.152596
80B:B:R283 4.5725409
81B:B:Y289 4.392597
82B:B:W297 4.882598
83B:B:H311 7.856569
84B:B:C317 2.975407
85B:B:T321 6.552587
86B:B:D323 6.6425487
87B:B:G324 2.7425489
88B:B:M325 2.554505
89B:B:W332 11.755229
90B:B:L336 3.304577
91B:B:K337 5.888566
92B:B:W339 6.466569
93G:G:L19 4.714219
94G:G:V30 2.55408
95G:G:Y40 6.19754116
96G:G:D48 5.528509
97R:R:N843 4.84254278
98R:R:F844 4.022519
99R:R:I872 3.29519
100R:R:T885 5.72254129
101R:R:F886 3.7925409
102R:R:F889 4.514128
103R:R:I899 3.962549
104R:R:H900 5.71449
105R:R:F914 3.34418
106R:R:F930 3.1675405
107R:R:H935 4.5125419
108R:R:F936 4.4975407
109R:R:L939 3.286519
110R:R:F942 5.2625409
111R:R:W944 7.98649
112R:R:E948 7.87449
113R:R:G949 2.3925446
114R:R:Q951 3.175408
115R:R:F960 5.69409
116R:R:R966 4.9575409
117R:R:P978 2.286509
118R:R:S992 4.3975418
119R:R:Y993 3.61167619
120R:R:W1000 7.5425418
121R:R:L1001 5.7418
122R:R:F1007 2.462518
123R:R:I1008 3.3875417
124R:R:F1011 3.668519
125R:R:N1022 3.11448
126R:R:H1036 3.4425405
127R:R:N1049 5.14254306
128R:R:W1053 6.29507
129R:R:L1063 7.2325449
130R:R:L1066 2.46408
131R:R:W1068 9.43419
132R:R:Y1074 6.6054287
133R:R:Y1084 5.49408
134R:R:F1086 6.66519
135R:R:F1098 5.546506
136R:R:C1102 4.14129
137R:R:Y1112 4.8865125
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:S84 B:B:W63 13.09423.71NoYes057
2B:B:S84 B:B:Y85 12.69472.54NoNo054
3B:B:D83 B:B:Y85 11.82672.3YesNo2384
4B:B:C114 B:B:L95 10.0273.17NoNo088
5B:B:C114 B:B:G115 15.00593.92NoNo089
6B:B:G115 B:B:T102 10.66211.82NoNo098
7B:B:C149 B:B:T102 11.13533.38NoNo088
8B:B:C149 B:B:T159 11.82511.69NoYes089
9B:B:H142 B:B:S161 18.619212.55YesYes099
10B:B:G162 B:B:S161 26.73331.86NoYes099
11B:B:G162 B:B:Y145 26.7562.9NoYes1498
12B:B:L117 B:B:Y145 37.79873.52YesYes098
13B:B:L117 B:B:W99 39.27764.56YesYes099
14B:B:Q75 B:B:W99 73.83885.48NoYes099
15B:B:Q75 B:B:Y59 73.609612.4NoNo098
16B:B:W332 B:B:Y59 73.30512.89YesNo2298
17B:B:S316 B:B:W332 45.03713.71NoYes099
18B:B:C317 B:B:S316 44.87123.44YesNo079
19B:B:C317 B:B:M61 37.56234.86YesNo076
20B:B:M61 B:B:W63 29.16293.49NoYes067
21B:B:D186 B:B:Y145 10.21623.45YesYes1498
22A:A:L48 A:A:P217 88.6481.64NoYes064
23A:A:K50 A:A:L48 88.60394.23NoNo096
24A:A:K219 A:A:K50 88.51457.18NoNo069
25A:A:K219 A:A:V221 88.42373.04NoNo066
26A:A:V221 B:B:W99 87.86493.68NoYes069
27A:A:F218 A:A:V216 76.75055.24YesNo074
28A:A:P217 A:A:V216 88.98713.53YesNo044
29A:A:F218 A:A:V49 92.5893.93YesNo076
30A:A:T241 A:A:V49 92.39844.76NoNo086
31A:A:F211 A:A:M220 11.25144.98YesYes088
32A:A:F211 A:A:F218 13.48894.29YesYes087
33A:A:S242 A:A:T241 92.22943.2YesNo088
34A:A:I286 A:A:V276 29.64563.07NoYes076
35A:A:R334 A:A:V276 82.26892.62NoYes076
36A:A:Q338 A:A:R334 82.77729.35NoNo037
37A:A:Q338 R:R:K1041 83.28514.07NoNo038
38A:A:P341 R:R:K1041 83.4655.02YesNo1558
39A:A:K340 A:A:P341 43.31385.02NoYes075
40A:A:K340 A:A:T365 44.00293NoNo076
41A:A:S285 A:A:T365 44.24477.99NoNo086
42A:A:S242 A:A:S285 44.4874.89YesNo088
43A:A:F245 A:A:F272 25.88573.22YesNo099
44A:A:F272 A:A:V276 49.58323.93NoYes096
45A:A:P341 A:A:Y343 45.76638.34YesNo059
46A:A:D361 A:A:Y343 48.71079.2NoNo079
47A:A:D361 A:A:I287 49.42624.2NoYes079
48A:A:I287 A:A:S242 48.62123.1YesYes098
49A:A:F218 A:A:F359 30.37754.29YesYes079
50A:A:F359 R:R:F960 30.34167.5YesYes099
51A:A:V216 R:R:F960 71.50046.55NoYes049
52A:A:F245 A:A:L288 21.69542.44YesNo099
53A:A:F330 A:A:L288 21.59512.44NoNo089
54A:A:F272 A:A:F330 23.19395.36NoNo098
55A:A:F252 A:A:I305 13.02397.54NoNo096
56A:A:F312 A:A:I305 14.65023.77YesNo056
57A:A:F312 A:A:V322 39.01712.62YesNo057
58A:A:L319 A:A:V322 40.63812.98YesNo037
59A:A:L319 A:A:Q323 50.35573.99YesNo035
60A:A:F346 A:A:Q323 51.97416.4YesNo055
61A:A:F346 A:A:V327 60.05972.62YesNo055
62A:A:H344 A:A:V327 61.67569.69NoNo055
63A:A:H344 A:A:L288 42.19812.57NoNo059
64A:A:H344 A:A:R331 21.1014.51NoNo053
65A:A:L342 A:A:R331 21.63277.29NoNo063
66A:A:I286 A:A:L342 22.16724.28NoNo076
67A:A:F312 A:A:F325 11.39576.43YesYes056
68A:A:I366 R:R:F960 1002.51NoYes089
69A:A:I366 A:A:N370 99.4614.25NoNo088
70A:A:L374 R:R:M955 99.05271.41NoNo058
71A:A:N370 R:R:M955 99.2575.61NoNo088
72R:R:G949 R:R:N1022 30.83051.7YesYes468
73R:R:E948 R:R:G949 32.22231.64YesYes496
74R:R:E948 R:R:H900 31.984711.08YesYes499
75R:R:H900 R:R:R896 73.10535.64YesNo099
76A:A:L374 R:R:R896 98.43753.64NoNo059
77R:R:H900 R:R:L1063 24.83473.86YesYes499
78B:B:D83 B:B:L69 11.16735.43YesNo085
79B:B:L69 B:B:Y105 11.11562.34NoYes056
80B:B:H62 B:B:Y105 10.30883.27NoYes066
81B:B:H62 B:B:R150 10.177110.16NoNo066
82B:B:A208 B:B:G202 11.29661.95NoNo066
83B:B:A208 B:B:F241 11.47462.77NoYes066
84B:B:R314 B:B:W332 31.319919.99NoYes089
85B:B:D290 B:B:R314 30.961513.1NoNo068
86B:B:C271 B:B:D290 30.10967.78NoNo056
87B:B:C271 B:B:D291 29.92653.11NoNo058
88B:B:D291 B:B:Y289 28.97693.45NoYes087
89B:B:T321 B:B:W63 17.138410.92YesYes877
90B:B:G324 B:B:T321 15.04151.82YesYes897
91B:B:H142 B:B:W169 10.70526.35YesYes1098
92B:B:F241 B:B:I232 17.34876.28YesYes068
93B:B:I232 B:B:T243 19.16323.04YesNo088
94B:B:I273 B:B:Y289 21.86136.04YesYes967
95B:B:G244 B:B:T243 21.86323.64NoNo058
96B:B:G244 B:B:I273 21.08221.76NoYes956
97R:R:F886 R:R:H900 17.542.26YesYes099
98R:R:C882 R:R:F886 11.60024.19NoYes069
99R:R:C882 R:R:C904 10.11733.64NoNo2968
100R:R:F908 R:R:L879 19.30342.44NoNo089
101R:R:F908 R:R:L876 18.23033.65NoNo089
102R:R:I872 R:R:L876 26.70012.85YesNo099
103R:R:I872 R:R:T868 11.76253.04YesNo198
104R:R:T1087 R:R:T868 11.33753.14NoNo088
105R:R:L864 R:R:T1087 10.47024.42NoNo078
106R:R:I1097 R:R:L1063 22.83492.85NoYes089
107R:R:G1094 R:R:I1097 21.53441.76NoNo088
108R:R:G1094 R:R:S875 11.4243.71NoNo089
109R:R:I1018 R:R:N1022 24.06332.83NoYes058
110R:R:F942 R:R:I1018 22.72862.51YesNo095
111R:R:Q951 R:R:R896 25.36143.5YesNo089
112R:R:I899 R:R:Q951 23.42592.74YesYes098
113R:R:I899 R:R:W944 22.06915.87YesYes499
114R:R:F1011 R:R:F942 16.78295.36YesYes099
115R:R:G974 R:R:W944 13.39344.22NoYes099
116R:R:G974 R:R:T943 13.13683.64NoNo095
117R:R:P978 R:R:T943 12.87271.75YesNo095
118R:R:F1007 R:R:S992 12.28211.32YesYes188
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7SF7
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRL3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi2-G13)/Beta1/Gamma2
PDB Resolution 2.9
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04575-7
Net Summary
Imin 1.64
Number of Linked Nodes 823
Number of Links 966
Number of Hubs 137
Number of Links mediated by Hubs 501
Number of Communities 30
Number of Nodes involved in Communities 181
Number of Links involved in Communities 235
Path Summary
Number Of Nodes in MetaPath 119
Number Of Links MetaPath 118
Number of Shortest Paths 1001325
Length Of Smallest Path 3
Average Path Length 30.9488
Length of Longest Path 57
Minimum Path Strength 1.28
Average Path Strength 4.65713
Maximum Path Strength 19.86
Minimum Path Correlation 0.7
Average Path Correlation 0.979385
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 42.9511
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.0311
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cell adhesion   • cell-cell adhesion   • cellular process   • cell-cell adhesion via plasma-membrane adhesion molecules   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • cell surface receptor signaling pathway   • developmental process   • multicellular organismal process   • neuron migration   • cellular developmental process   • nervous system development   • generation of neurons   • neurogenesis   • multicellular organism development   • cell differentiation   • anatomical structure development   • cell migration   • cell motility   • system development   • cellular component organization   • cellular component biogenesis   • cell junction organization   • cellular component assembly   • cell junction assembly   • synapse organization   • cellular component organization or biogenesis   • synapse assembly   • cellular anatomical structure   • membrane   • cell-cell junction   • anchoring junction   • cell junction   • cell periphery   • plasma membrane   • synapse   • glutamatergic synapse   • axon   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • D5 dopamine receptor binding   • dopamine receptor binding   • enzyme regulator activity   • hydrolase activity   • GDP binding   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • nucleoside-triphosphatase regulator activity   • GTPase regulator activity   • guanyl-nucleotide exchange factor activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • cation binding   • metal ion binding   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • system process   • circulatory system process   • regulation of blood pressure   • blood circulation   • regulation of vascular associated smooth muscle cell migration   • negative regulation of locomotion   • vascular associated smooth muscle cell migration   • regulation of cell motility   • negative regulation of vascular associated smooth muscle cell migration   • regulation of smooth muscle cell migration   • negative regulation of biological process   • smooth muscle cell migration   • muscle cell migration   • negative regulation of smooth muscle cell migration   • regulation of locomotion   • regulation of cell migration   • negative regulation of cellular process   • negative regulation of cell motility   • locomotion   • negative regulation of cell migration   • regulation of fibroblast migration   • fibroblast migration   • ameboidal-type cell migration   • embryo development ending in birth or egg hatching   • chordate embryonic development   • embryo development   • in utero embryonic development   • regulation of developmental process   • regulation of cell shape   • cell morphogenesis   • regulation of cell morphogenesis   • anatomical structure morphogenesis   • regulation of anatomical structure morphogenesis   • regulation of body fluid levels   • wound healing   • cell activation   • hemostasis   • blood coagulation   • response to stress   • coagulation   • response to wounding   • platelet activation   • branching morphogenesis of an epithelial tube   • angiogenesis   • tube morphogenesis   • epithelial tube morphogenesis   • blood vessel development   • epithelium development   • blood vessel morphogenesis   • tube development   • morphogenesis of an epithelium   • tissue development   • vasculature development   • circulatory system development   • branching involved in blood vessel morphogenesis   • tissue morphogenesis   • morphogenesis of a branching structure   • anatomical structure formation involved in morphogenesis   • morphogenesis of a branching epithelium   • regulation of cellular component organization   • regulation of postsynapse assembly   • regulation of synapse structure or activity   • regulation of synapse assembly   • postsynapse organization   • postsynapse assembly   • regulation of postsynapse organization   • regulation of cellular component biogenesis   • regulation of cell junction assembly   • regulation of synapse organization   • Rho-activating G protein-coupled receptor signaling pathway   • regulation of signaling   • small GTPase-mediated signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • regulation of intracellular signal transduction   • regulation of response to stimulus   • intracellular signaling cassette   • regulation of cell communication   • Rho protein signal transduction   • regulation of vascular associated smooth muscle cell proliferation   • negative regulation of cell population proliferation   • cell population proliferation   • regulation of smooth muscle cell proliferation   • negative regulation of vascular associated smooth muscle cell proliferation   • smooth muscle cell proliferation   • negative regulation of smooth muscle cell proliferation   • regulation of cell population proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • focal adhesion   • cell-substrate junction   • membrane-bounded organelle   • intracellular anatomical structure   • pigment granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • intracellular organelle   • melanosome   • cytoplasmic vesicle   • organelle   • cytoplasm   • vesicle   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • cytosol   • brush border membrane   • cluster of actin-based cell projections   • brush border   • plasma membrane region   • cell projection membrane   • postsynapse   • nucleus   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • Ras protein signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • G-protein beta-subunit binding   • fibroblast proliferation
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>7SF7_Chain_A
EDKAAAERS KEIDKCLSR EKTYVKRLV KILLLGADN SGKSTFLKQ 
MRIIKGIHE YDFEIKNVP FKMVDVGGQ RSERKRWFE CFDSVTSIL 
FLVDSSDFN RLTESLNDF ETIVNNRVF SNVSIILFL NKTDLLEEK 
VQIVSIKDY FLEFEGDPH CLRDVQKFL VECFRNKRR DQQQKPLYH 
HFTTAINTE NARLIFRDV KDTILHDNL KQLMLQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7SF7_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7SF7_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9HAR2
Sequence
>7SF7_Chain_R
TNFAVLMAH VEVKHSDAV HDLLLDVIT WVGILLSLV CLLICIFTF 
CFFRGLQSD RNTIHKNLC ISLFVAELL FLIGINRTD QPIACAVFA 
ALLHFFFLA AFTWMFLEG VQLYIMLVE VFESEHSRR KYFYLVGYG 
MPALIVAVS AAVDYRSYG TDKVCWLRL DTYFIWSFI GPATLIIML 
NVIFLGIAL YKMFHHTAI LKPESGCLD NIKSWVIGA IALLCLLGL 
TWAFGLMYI NESTVIMAY LFTIFNSLQ GMFIFIFHC VLQKKVRKE 
YGKCL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JMTB2AdhesionAdhesionADGRL3Homo sapiens---3.32023-09-0610.1038/s41589-023-01389-0
7X10B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-G12)/β1/γ22.932022-10-2610.1016/j.molcel.2022.10.009
7X10 (No Gprot) B2AdhesionAdhesionADGRL3Mus musculus--2.932022-10-2610.1016/j.molcel.2022.10.009
7WY5B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs-CtGq)/β1/γ22.832022-10-2610.1016/j.molcel.2022.10.009
7WY5 (No Gprot) B2AdhesionAdhesionADGRL3Mus musculus--2.832022-10-2610.1016/j.molcel.2022.10.009
7WY8B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs)/β1/γ22.832022-10-2610.1016/j.molcel.2022.10.009
7WY8 (No Gprot) B2AdhesionAdhesionADGRL3Mus musculus--2.832022-10-2610.1016/j.molcel.2022.10.009
7WYBB2AdhesionAdhesionADGRL3Mus musculus--Gi1/β1/γ22.972022-10-2610.1016/j.molcel.2022.10.009
7WYB (No Gprot) B2AdhesionAdhesionADGRL3Mus musculus--2.972022-10-2610.1016/j.molcel.2022.10.009
7SF7B2AdhesionAdhesionADGRL3Homo sapiens--chim(NtGi2-G13)/β1/γ22.92022-04-2710.1038/s41586-022-04575-7
7SF7 (No Gprot) B2AdhesionAdhesionADGRL3Homo sapiens--2.92022-04-2710.1038/s41586-022-04575-7




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