Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L23 3.6125476
2A:A:L36 4.045407
3A:A:L39 3.0875409
4A:A:K46 3.345199
5A:A:M53 7.24754128
6A:A:I55 8.2885128
7A:A:E186 6.2575439
8A:A:F189 7.3945129
9A:A:F199 8.414535
10A:A:V201 4.3925439
11A:A:Q204 4.446539
12A:A:W211 6.8725439
13A:A:F215 4.1775439
14A:A:T219 3.615407
15A:A:F223 5.3925119
16A:A:Y230 6.378577108
17A:A:R242 5.694109
18A:A:F250 6.015119
19A:A:W258 4.8425405
20A:A:F259 5.914219
21A:A:I265 3.22468
22A:A:F267 4.625669
23A:A:F274 4.5965109
24A:A:L283 3.7025407
25A:A:Y290 6.624137
26A:A:Y296 5.5775404
27A:A:N311 2.7675408
28A:A:Y320 8.93407
29A:A:D328 6.04409
30A:A:N331 5.732568
31A:A:L348 3.855409
32B:B:L7 5.205408
33B:B:I18 3.772507
34B:B:L30 4.31254145
35B:B:T34 4.474145
36B:B:V40 3.28403
37B:B:L51 7.2625409
38B:B:H54 5.188579
39B:B:Q75 8.3725409
40B:B:K78 4.6125478
41B:B:I80 4.93578
42B:B:I81 4.555177
43B:B:Y85 10.024244
44B:B:K89 7.95667679
45B:B:H91 5.2625175
46B:B:I93 3.99507
47B:B:W99 6.345439
48B:B:T102 3.115408
49B:B:Y105 4.214506
50B:B:N110 5.7025444
51B:B:Y111 6.69544
52B:B:L117 4.81333639
53B:B:I123 3.1875446
54B:B:Y124 4.264506
55B:B:L126 3.21754175
56B:B:E130 5.34254253
57B:B:H142 5.866549
58B:B:Y145 4.76667638
59B:B:F151 3.52549
60B:B:L152 6.3625453
61B:B:V158 4.335455
62B:B:T159 5.905449
63B:B:D163 6.3425409
64B:B:W169 9.28648
65B:B:I171 2.805446
66B:B:F180 6.686557
67B:B:H183 5.94143759
68B:B:L190 6.1025455
69B:B:F199 5.91333659
70B:B:V200 4.3975426
71B:B:S201 4.058559
72B:B:D205 6.4375409
73B:B:K209 7.78556
74B:B:W211 8.105658
75B:B:E215 5.87754263
76B:B:R219 5.9275425
77B:B:Q220 9.322527
78B:B:H225 8.19857729
79B:B:D228 7.2025409
80B:B:I232 5.1575428
81B:B:F234 4.922505
82B:B:F235 7.675166
83B:B:N237 5.003336165
84B:B:F241 6.72333626
85B:B:T243 4.09667628
86B:B:D247 5.8525429
87B:B:T249 4.34426
88B:B:R251 11.846528
89B:B:D254 4.205429
90B:B:L255 6.2125426
91B:B:Y264 5.50167605
92B:B:L285 3.81406
93B:B:L286 3.4985187
94B:B:Y289 7.134277
95B:B:D290 10.44754286
96B:B:V296 3.81254185
97B:B:W297 5.645278
98B:B:K301 4.90754145
99B:B:V315 3.8487
100B:B:M325 5.695155
101B:B:T329 4.3488
102B:B:W332 19.1725409
103B:B:D333 7.3625489
104B:B:K337 4.92486
105B:B:W339 7.218589
106B:B:N340 6.1775409
107G:G:L19 2.845409
108G:G:R27 6.5525408
109G:G:D48 5.19409
110G:G:P49 5.20254157
111G:G:V54 3.7725156
112G:G:F61 5.9525248
113R:R:N924 4.278508
114R:R:F925 6.434599
115R:R:L928 6.0325409
116R:R:H941 5.918505
117R:R:L960 3.64167619
118R:R:C963 4.044517
119R:R:I964 3.6075417
120R:R:T966 6.35419
121R:R:F967 6.482519
122R:R:F970 9.35518
123R:R:D976 3.135409
124R:R:R977 4.5425419
125R:R:H981 7.69419
126R:R:F1017 5.1475408
127R:R:W1025 7.854509
128R:R:Q1032 5.548518
129R:R:F1041 4.73754209
130R:R:R1048 2.94404
131R:R:P1059 3.934509
132R:R:Y1074 2.884509
133R:R:W1081 5.675296
134R:R:I1089 3.2385299
135R:R:I1093 2.2025408
136R:R:I1099 2.645405
137R:R:M1114 4.28254238
138R:R:L1153 6.265419
139R:R:W1158 8.25598
140R:R:Y1164 6.87254306
141R:R:F1176 5.24333699
142R:R:N1180 11.625499
143R:R:F1188 6.316517
144R:R:F1190 4.852518
145R:R:H1191 5.4575418
146R:R:Y1202 9.8125417
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 25.79613.57NoNo085
2B:B:D66 B:B:L69 25.93514.07NoNo085
3B:B:L117 B:B:Y145 95.20474.69YesYes398
4B:B:G162 B:B:Y145 94.1375.79NoYes398
5B:B:G162 B:B:S161 94.15863.71NoNo099
6B:B:H142 B:B:S161 93.937513.95YesNo099
7B:B:H142 B:B:T159 90.22322.74YesYes499
8B:B:C121 B:B:T159 91.01053.38NoYes089
9B:B:C121 B:B:C149 90.9133.64NoNo088
10B:B:C149 B:B:T102 90.81553.38NoYes088
11B:B:R150 B:B:T102 30.97123.88NoYes068
12B:B:H62 B:B:R150 30.94543.39NoNo066
13B:B:H62 B:B:Y105 30.80184.36NoYes066
14B:B:L69 B:B:Y105 26.42423.52NoYes056
15A:A:W211 B:B:L117 94.73384.56YesYes399
16A:A:R208 A:A:W211 96.12369NoYes099
17A:A:L39 A:A:R208 96.21133.64YesNo099
18A:A:I253 A:A:L39 98.93662.85NoYes089
19A:A:F223 A:A:I253 98.98222.51YesNo1198
20A:A:F223 A:A:V225 49.33352.62YesNo097
21A:A:F307 A:A:V225 49.81932.62NoNo087
22A:A:F307 A:A:I303 1002.51NoNo087
23A:A:I303 A:A:L227 51.04657.14NoNo077
24A:A:F274 A:A:L227 50.59474.87YesNo097
25A:A:F274 A:A:Y230 48.34556.19YesYes1098
26A:A:D231 A:A:Y230 96.083811.49NoYes1098
27A:A:D231 A:A:L232 95.97388.14NoNo1098
28A:A:D229 A:A:L232 95.32294.07NoNo1088
29A:A:D229 A:A:S228 95.27185.89NoNo089
30A:A:K270 A:A:S228 94.990212.24NoNo099
31A:A:K270 A:A:N269 94.67872.8NoNo699
32A:A:N269 A:A:T324 94.56718.77NoNo699
33A:A:F267 A:A:T324 92.03535.19YesNo699
34A:A:F267 A:A:V335 88.69032.62YesNo698
35A:A:L36 A:A:V335 88.65752.98YesNo078
36A:A:F196 A:A:L36 87.36226.09NoYes077
37A:A:F196 A:A:V34 86.79759.18NoNo075
38A:A:L194 A:A:V34 86.0282.98NoNo045
39A:A:F223 A:A:L266 49.28844.87YesNo1199
40A:A:F307 A:A:L266 50.20133.65NoNo089
41A:A:I303 A:A:Y287 48.95143.63NoNo077
42A:A:C286 A:A:Y287 48.42114.03NoNo067
43A:A:C286 A:A:Y230 48.26264.03NoYes068
44A:A:L194 R:R:F1041 85.88136.09NoYes049
45R:R:F1041 R:R:V1040 85.41439.18YesNo2099
46A:A:I344 R:R:V1040 85.29353.07NoNo069
47A:A:I344 A:A:L348 84.55631.43NoYes069
48A:A:C351 R:R:L1037 82.77623.17NoNo048
49A:A:L348 R:R:L1037 82.92529.69YesNo098
50A:A:C351 R:R:R977 82.15142.79NoYes049
51B:B:F199 B:B:W211 56.1028.02YesYes598
52B:B:K209 B:B:W211 27.21378.12YesYes568
53B:B:K209 B:B:T221 27.082515.02YesNo067
54B:B:T221 G:G:E22 26.95449.88NoNo079
55B:B:I18 G:G:E22 53.37472.73YesNo079
56B:B:C218 B:B:W211 27.07413.06NoYes558
57B:B:C218 G:G:Q18 26.94754.58NoNo059
58G:G:E22 G:G:Q18 26.689910.19NoNo099
59B:B:I18 G:G:R27 45.54942.51YesYes078
60G:G:I25 G:G:R27 16.95956.26NoYes028
61B:B:R219 G:G:I25 10.02186.26YesNo252
62B:B:R68 B:B:Y85 18.553918.52NoYes054
63B:B:Y85 G:G:P60 16.13829.74YesNo049
64B:B:M325 G:G:P60 15.289710.06YesNo059
65B:B:M325 G:G:P49 12.23918.39YesYes1557
66G:G:D48 G:G:P49 11.57414.83YesYes097
67B:B:S279 G:G:D48 10.63435.89NoYes099
68B:B:S279 B:B:V320 10.50143.23NoNo097
69B:B:V320 B:B:V327 10.3693.21NoNo076
70B:B:C148 B:B:T102 59.62793.38NoYes068
71B:B:C148 B:B:L190 59.50846.35NoYes065
72B:B:F241 B:B:T243 11.23072.59YesYes268
73B:B:F234 B:B:L255 23.40154.87YesYes056
74B:B:L210 B:B:L255 18.4869.69NoYes256
75B:B:D258 G:G:R27 28.055211.91NoYes078
76B:B:L210 B:B:Q220 12.76053.99NoYes257
77B:B:F222 B:B:F241 21.01128.57NoYes286
78B:B:D258 B:B:F222 21.12845.97NoNo278
79B:B:F234 B:B:G238 17.81784.52YesNo057
80B:B:G238 B:B:N237 16.70913.39NoYes075
81R:R:H981 R:R:R977 77.51814.51YesYes199
82R:R:F967 R:R:H981 74.333811.31YesYes199
83R:R:C963 R:R:F967 70.11876.98YesYes179
84R:R:C963 R:R:L960 43.9963.17YesYes179
85R:R:E992 R:R:L960 18.63572.65NoYes199
86R:R:E992 R:R:L957 18.4757.95NoNo099
87R:R:L996 R:R:W950 16.91873.42NoNo097
88R:R:D946 R:R:W950 16.5688.93NoNo047
89R:R:D946 R:R:N924 14.79054.04NoYes048
90R:R:I964 R:R:L960 24.90165.71YesYes179
91R:R:F989 R:R:I964 49.06192.51NoYes087
92R:R:F989 R:R:V990 48.71172.62NoNo085
93R:R:F1018 R:R:V990 48.36167.87NoNo085
94R:R:A991 R:R:F1018 42.04484.16NoNo088
95R:R:A991 R:R:F1019 41.6934.16NoNo089
96R:R:F1019 R:R:L928 29.13227.31NoYes099
97R:R:F925 R:R:L928 15.96854.87YesYes099
98R:R:C963 R:R:C985 25.03823.64YesNo179
99R:R:C985 R:R:I964 24.8673.27NoYes197
100R:R:L928 R:R:W1081 11.98023.42YesYes096
101R:R:F1019 R:R:F1092 12.21825.36NoNo099
102R:R:F1092 R:R:W1081 11.860710.02NoYes096
103R:R:F1176 R:R:G1161 10.85856.02YesNo099
104R:R:G1161 R:R:M1172 10.13541.75NoNo098
105R:R:L1082 R:R:W1081 14.46424.56NoYes2986
106R:R:L1082 R:R:S1073 13.78863NoNo089
107B:B:F199 B:B:L190 56.96116.09YesYes595
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WYB
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRL3
Species Mus musculus
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.97
Date 2022-10-26 
D.O.I. 10.1016/j.molcel.2022.10.009
Net Summary
Imin 2.51
Number of Linked Nodes 829
Number of Links 984
Number of Hubs 146
Number of Links mediated by Hubs 554
Number of Communities 31
Number of Nodes involved in Communities 223
Number of Links involved in Communities 301
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 2192168
Length Of Smallest Path 3
Average Path Length 54.0829
Length of Longest Path 86
Minimum Path Strength 1.27
Average Path Strength 5.51242
Maximum Path Strength 29.66
Minimum Path Correlation 0.7
Average Path Correlation 0.987431
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.51515
Average % Of Corr. Nodes 28.2869
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.0917
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7WYB_Chain_A
GCTLSAEDK AAVERSKMI DRNLREDGE KAAREVKLL LLGAGESGK 
NTIVKQMKI TGIVETHFT FKDLHFKMF DVGAQRSER KKWIHCFEG 
VTAIIFCVA LSDYDLVLA EDEEMNRMH ASMKLFDSI CNNKWFTDT 
SIILFLNKK DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF 
EDLNKRKDT KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG 
L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WYB_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WYB_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ80TS3
Sequence
>7WYB_Chain_R
TNFAVLMAH VEVKHSDAV HDLLLDVIT WVGILLSLV CLLICIFTF 
CFFRGLQSD RNTIHKNLC ISLFVAELL FLIGINRTD QPIACAVFA 
ALLHFFFLA AFTWMFLEG VQLYIMLVE VFESEHSRR KYFYLVGYG 
MPALIVAVS AAVDYRSYG TDKVCWLRL DTYFIWSFI GPATLIIML 
NVIFLGIAL YKMFHHTWV IGAIALLCL LGLTWAFGL MYINESTVI 
MAYLFTIFN SLQGMFIFI FHCVLQKKV RKEYGKCLR T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SF7B2AdhesionAdhesionADGRL3Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;22.92022-04-2710.1038/s41586-022-04575-7
7WY5B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WY8B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WYBB2AdhesionAdhesionADGRL3Mus musculus--Gi1/&β;1/&γ;22.972022-10-2610.1016/j.molcel.2022.10.009
7X10B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-G12)/&β;1/&γ;22.932022-10-2610.1016/j.molcel.2022.10.009
8JMTB2AdhesionAdhesionADGRL3Homo sapiens---3.32023-09-0610.1038/s41589-023-01389-0




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WYB.zip



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