psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N1000	R:R:T923	4.39	No	No	0	6	9
2	R:R:T923	R:R:V1079	3.17	No	No	0	9	5
3	R:R:L945	R:R:N924	9.61	No	No	0	8	8
4	R:R:F925	R:R:T949	7.78	No	No	0	9	8
5	R:R:F925	R:R:I953	3.77	No	No	0	9	9
6	R:R:F1176	R:R:F925	3.22	Yes	No	0	9	9
7	R:R:F995	R:R:L928	3.65	No	No	0	8	9
8	R:R:F1019	R:R:L928	3.65	Yes	No	0	9	9
9	R:R:L928	R:R:W1081	3.42	No	Yes	0	9	6
10	R:R:M929	R:R:W1158	3.49	No	Yes	5	9	8
11	R:R:F1176	R:R:M929	4.98	Yes	No	5	9	9
12	R:R:H931	R:R:V932	6.92	No	No	2	6	5
13	R:R:H931	R:R:W1090	3.17	No	Yes	2	6	7
14	R:R:H931	R:R:I1165	2.65	No	No	2	6	6
15	R:R:I1165	R:R:V932	3.07	No	No	2	6	5
16	R:R:E933	R:R:V934	2.85	No	No	0	4	4
17	R:R:E933	R:R:L1084	2.65	No	No	0	4	5
18	R:R:K935	R:R:S937	3.06	No	No	0	2	1
19	R:R:K935	R:R:Y1164	11.94	No	No	0	2	6
20	R:R:E1167	R:R:K935	6.75	No	No	0	5	2
21	R:R:D942	R:R:S937	5.89	No	No	0	4	1
22	R:R:D938	R:R:E1167	2.6	No	No	0	1	5
23	R:R:A939	R:R:H941	4.39	No	No	0	1	5
24	R:R:H941	R:R:Y1174	6.53	No	Yes	0	5	9
25	R:R:L943	R:R:V947	2.98	No	No	0	4	6
26	R:R:L944	R:R:Y1174	2.34	No	Yes	0	5	9
27	R:R:L945	R:R:Y1174	4.69	No	Yes	0	8	9
28	R:R:L945	R:R:T1177	4.42	No	No	0	8	9
29	R:R:D946	R:R:W950	6.7	No	No	0	4	7
30	R:R:I948	R:R:T1177	3.04	No	No	0	9	9
31	R:R:T1177	R:R:T949	3.14	No	No	0	9	8
32	R:R:L996	R:R:W950	6.83	No	No	0	9	7
33	R:R:G952	R:R:S1181	3.71	No	No	0	9	7
34	R:R:I953	R:R:L996	4.28	No	No	0	9	9
35	R:R:L957	R:R:S956	3	No	Yes	3	9	9
36	R:R:L960	R:R:S956	3	Yes	Yes	3	9	9
37	R:R:E992	R:R:S956	5.75	No	Yes	3	9	9
38	R:R:G1184	R:R:S956	3.71	No	Yes	3	8	9
39	R:R:E992	R:R:L957	6.63	No	No	3	9	9
40	R:R:C959	R:R:F1188	8.38	No	Yes	0	9	7
41	R:R:C985	R:R:L960	3.17	No	Yes	0	9	9
42	R:R:F989	R:R:L960	2.44	No	Yes	0	8	9
43	R:R:G1184	R:R:L960	3.42	No	Yes	3	8	9
44	R:R:F989	R:R:L961	6.09	No	No	0	8	5
45	R:R:F1188	R:R:I962	8.79	Yes	No	0	7	5
46	R:R:C963	R:R:F967	2.79	No	Yes	1	7	9
47	R:R:C963	R:R:F1188	4.19	No	Yes	1	7	7
48	R:R:C1192	R:R:C963	3.64	No	No	1	9	7
49	R:R:C985	R:R:I964	3.27	No	No	0	9	7
50	R:R:I964	R:R:I986	4.42	No	No	0	7	5
51	R:R:F965	R:R:F969	9.65	No	No	0	8	8
52	R:R:F967	R:R:T966	3.89	Yes	No	0	9	9
53	R:R:T966	R:R:Y1202	11.24	No	No	0	9	7
54	R:R:F967	R:R:N978	7.25	Yes	No	0	9	9
55	R:R:F967	R:R:H981	3.39	Yes	Yes	1	9	9
56	R:R:C985	R:R:F967	2.79	No	Yes	0	9	9
57	R:R:C1192	R:R:F967	2.79	No	Yes	1	9	9
58	R:R:C968	R:R:K982	3.23	No	No	0	8	9
59	R:R:F969	R:R:F970	3.22	No	Yes	0	8	8
60	R:R:F970	R:R:L973	2.44	Yes	No	0	8	8
61	R:R:E1201	R:R:F970	5.83	No	Yes	0	8	8
62	R:R:F970	R:R:Y1202	4.13	Yes	No	0	8	7
63	R:R:C1205	R:R:F970	5.59	No	Yes	0	8	8
64	R:R:N978	R:R:Q974	3.96	No	No	0	9	9
65	R:R:D976	R:R:Q1032	2.61	No	Yes	1	9	8
66	R:R:D976	R:R:R1048	3.57	No	Yes	1	9	4
67	R:R:D976	R:R:F1051	3.58	No	No	1	9	5
68	R:R:H981	R:R:R977	9.03	Yes	No	1	9	9
69	R:R:E1029	R:R:R977	2.33	Yes	No	1	9	9
70	R:R:R1048	R:R:T979	3.88	Yes	No	1	4	9
71	R:R:T979	R:R:Y1052	3.75	No	No	1	9	9
72	R:R:I980	R:R:W1025	4.7	Yes	Yes	1	9	9
73	R:R:I980	R:R:L1028	2.85	Yes	No	1	9	7
74	R:R:E1029	R:R:I980	6.83	Yes	Yes	1	9	9
75	R:R:I980	R:R:Q1032	2.74	Yes	Yes	1	9	8
76	R:R:E1029	R:R:H981	8.62	Yes	Yes	1	9	9
77	R:R:H981	R:R:L1153	7.71	Yes	Yes	1	9	9
78	R:R:N983	R:R:W1025	19.21	No	Yes	1	9	9
79	R:R:N983	R:R:Y1052	6.98	No	No	1	9	9
80	R:R:N983	R:R:Y1056	5.81	No	Yes	1	9	9
81	R:R:L984	R:R:W1025	2.28	No	Yes	0	9	9
82	R:R:L984	R:R:M1026	4.24	No	Yes	0	9	8
83	R:R:A1021	R:R:S987	3.42	No	Yes	1	8	8
84	R:R:S987	R:R:W1025	2.47	Yes	Yes	1	8	9
85	R:R:S987	R:R:Y1056	2.54	Yes	Yes	1	8	9
86	R:R:F1018	R:R:V990	14.42	No	No	0	8	5
87	R:R:A991	R:R:F1019	8.32	No	Yes	0	8	9
88	R:R:I997	R:R:L993	4.28	No	No	0	5	5
89	R:R:L1014	R:R:L994	4.15	No	No	0	5	5
90	R:R:L1015	R:R:L994	2.77	No	No	0	9	5
91	R:R:F995	R:R:I999	5.02	No	No	0	8	8
92	R:R:G998	R:R:I997	3.53	No	No	0	9	5
93	R:R:G998	R:R:R1001	3	No	No	0	9	8
94	R:R:F1011	R:R:G998	3.01	No	No	0	5	9
95	R:R:I999	R:R:N1000	7.08	No	No	0	8	6
96	R:R:I999	R:R:V1079	4.61	No	No	0	8	5
97	R:R:C1008	R:R:R1001	2.79	No	No	0	9	8
98	R:R:D1003	R:R:Q1004	10.44	No	No	0	4	4
99	R:R:A1007	R:R:Q1004	6.06	No	No	0	4	4
100	R:R:C1008	R:R:F1011	5.59	No	No	0	9	5
101	R:R:C1008	R:R:C1080	7.28	No	No	0	9	8
102	R:R:A1012	R:R:Y1074	5.34	No	Yes	0	9	9
103	R:R:A1013	R:R:Y1074	2.67	No	Yes	0	8	9
104	R:R:F1019	R:R:L1015	2.44	Yes	No	0	9	9
105	R:R:L1015	R:R:W1081	4.56	No	Yes	0	9	6
106	R:R:H1016	R:R:L1020	7.71	Yes	Yes	6	9	9
107	R:R:H1016	R:R:L1082	2.57	Yes	No	0	9	8
108	R:R:H1016	R:R:S1091	6.97	Yes	No	0	9	9
109	R:R:F1092	R:R:H1016	3.39	Yes	Yes	6	9	9
110	R:R:F1017	R:R:F1018	10.72	Yes	No	0	8	8
111	R:R:F1017	R:R:P1059	2.89	Yes	Yes	0	8	9
112	R:R:F1017	R:R:V1063	3.93	Yes	No	0	8	9
113	R:R:F1019	R:R:F1092	3.22	Yes	Yes	0	9	9
114	R:R:L1020	R:R:P1059	3.28	Yes	Yes	0	9	9
115	R:R:I1062	R:R:L1020	2.85	No	Yes	0	8	9
116	R:R:F1092	R:R:L1020	3.65	Yes	Yes	6	9	9
117	R:R:A1021	R:R:Y1056	2.67	No	Yes	1	8	9
118	R:R:F1023	R:R:M1026	2.49	Yes	Yes	0	9	8
119	R:R:F1023	R:R:F1092	3.22	Yes	Yes	0	9	9
120	R:R:A1096	R:R:F1023	8.32	No	Yes	0	8	9
121	R:R:F1023	R:R:I1099	3.77	Yes	No	0	9	5
122	R:R:F1023	R:R:W1158	7.02	Yes	Yes	0	9	8
123	R:R:P1059	R:R:T1024	3.5	Yes	No	0	9	5
124	R:R:L1028	R:R:W1025	4.56	No	Yes	1	7	9
125	R:R:G1055	R:R:W1025	5.63	No	Yes	0	8	9
126	R:R:W1025	R:R:Y1056	5.79	Yes	Yes	1	9	9
127	R:R:M1026	R:R:Q1183	4.08	Yes	No	0	8	9
128	R:R:F1027	R:R:V1031	5.24	No	No	0	9	9
129	R:R:F1027	R:R:I1099	3.77	No	No	0	9	5
130	R:R:F1027	R:R:L1102	3.65	No	No	0	9	4
131	R:R:E1029	R:R:L1153	5.3	Yes	Yes	1	9	9
132	R:R:F1106	R:R:G1030	6.02	No	No	0	6	5
133	R:R:F1106	R:R:V1031	2.62	No	No	0	6	9
134	R:R:I1035	R:R:Q1032	4.12	No	Yes	0	7	8
135	R:R:M1036	R:R:Q1032	4.08	No	Yes	0	8	8
136	R:R:F1051	R:R:Q1032	2.34	No	Yes	1	5	8
137	R:R:A1110	R:R:L1033	4.73	No	No	0	8	9
138	R:R:I1035	R:R:Y1034	4.84	No	No	0	7	8
139	R:R:V1038	R:R:Y1034	15.14	No	No	0	8	8
140	R:R:E1039	R:R:Y1034	4.49	No	No	0	8	8
141	R:R:I1035	R:R:R1047	2.51	No	No	0	7	9
142	R:R:R1047	R:R:S1043	7.91	No	No	0	9	9
143	R:R:E1044	R:R:H1045	4.92	No	No	0	7	4
144	R:R:R1048	R:R:Y1052	3.09	Yes	No	1	4	9
145	R:R:K1049	R:R:Y1050	9.55	No	No	0	8	9
146	R:R:S1066	R:R:Y1074	2.54	No	Yes	4	9	9
147	R:R:F1088	R:R:S1066	7.93	Yes	No	4	8	9
148	R:R:S1066	R:R:S1091	4.89	No	No	0	9	9
149	R:R:D1070	R:R:S1073	8.83	No	No	4	9	9
150	R:R:D1070	R:R:F1088	2.39	No	Yes	4	9	8
151	R:R:R1072	R:R:Y1071	14.4	No	No	0	4	8
152	R:R:R1083	R:R:S1073	6.59	No	No	0	5	9
153	R:R:F1088	R:R:S1073	5.28	Yes	No	4	8	9
154	R:R:F1088	R:R:Y1074	8.25	Yes	Yes	4	8	9
155	R:R:R1083	R:R:T1076	2.59	No	No	0	5	9
156	R:R:L1082	R:R:W1081	11.39	No	Yes	0	8	6
157	R:R:I1089	R:R:W1081	3.52	Yes	Yes	0	9	6
158	R:R:F1092	R:R:W1081	4.01	Yes	Yes	0	9	6
159	R:R:F1088	R:R:L1082	6.09	Yes	No	0	8	8
160	R:R:D1085	R:R:R1083	15.48	No	No	0	8	5
161	R:R:I1089	R:R:L1084	5.71	Yes	No	0	9	5
162	R:R:D1085	R:R:T1086	2.89	No	No	0	8	8
163	R:R:W1090	R:R:Y1087	4.82	Yes	No	0	7	6
164	R:R:I1089	R:R:W1090	3.52	Yes	Yes	2	9	7
165	R:R:I1089	R:R:I1093	2.94	Yes	No	2	9	8
166	R:R:I1093	R:R:W1090	3.52	No	Yes	2	8	7
167	R:R:G1094	R:R:P1095	4.06	No	No	0	9	9
168	R:R:L1162	R:R:T1097	7.37	No	No	0	8	6
169	R:R:L1154	R:R:N1103	12.36	Yes	No	0	6	9
170	R:R:L1107	R:R:L1150	2.77	No	No	0	8	9
171	R:R:L1107	R:R:L1154	2.77	No	Yes	0	8	6
172	R:R:H1116	R:R:Y1112	10.89	No	No	0	5	4
173	R:R:M1114	R:R:W1143	9.31	No	No	0	8	7
174	R:R:H1116	R:R:H1117	2.39	No	No	0	5	6
175	R:R:V1144	R:R:W1143	4.9	No	No	0	8	7
176	R:R:I1148	R:R:V1144	3.07	No	No	0	5	8
177	R:R:F1190	R:R:I1148	2.51	Yes	No	0	8	5
178	R:R:A1149	R:R:F1190	6.93	No	Yes	0	5	8
179	R:R:L1151	R:R:L1156	2.77	No	Yes	0	9	6
180	R:R:C1152	R:R:L1153	3.17	No	Yes	1	6	9
181	R:R:C1152	R:R:I1187	3.27	No	No	1	6	9
182	R:R:C1152	R:R:H1191	2.95	No	No	1	6	8
183	R:R:I1187	R:R:L1153	2.85	No	Yes	1	9	9
184	R:R:H1191	R:R:L1153	11.57	No	Yes	1	8	9
185	R:R:L1154	R:R:L1156	2.77	Yes	Yes	0	6	6
186	R:R:N1180	R:R:T1157	4.39	No	No	0	9	9
187	R:R:F1176	R:R:W1158	4.01	Yes	Yes	5	9	8
188	R:R:N1180	R:R:W1158	14.69	No	Yes	5	9	8
189	R:R:Q1183	R:R:W1158	6.57	No	Yes	0	9	8
190	R:R:F1160	R:R:M1172	4.98	No	Yes	0	8	8
191	R:R:F1176	R:R:G1161	6.02	Yes	No	0	9	9
192	R:R:M1163	R:R:M1172	4.33	No	Yes	0	6	8
193	R:R:A1173	R:R:Y1164	9.34	No	No	0	9	6
194	R:R:I1165	R:R:N1166	5.66	No	No	0	6	7
195	R:R:N1166	R:R:T1169	4.39	No	No	0	7	8
196	R:R:E1167	R:R:V1170	4.28	No	No	0	5	4
197	R:R:V1170	R:R:Y1174	2.52	No	Yes	0	4	9
198	R:R:F1176	R:R:N1180	18.12	Yes	No	5	9	9
199	R:R:L1182	R:R:S1181	3	No	No	0	6	7
200	R:R:L1182	R:R:M1185	5.65	No	No	7	6	7
201	R:R:F1186	R:R:L1182	2.44	No	No	7	8	6
202	R:R:F1186	R:R:M1185	3.73	No	No	7	8	7
203	R:R:C1192	R:R:F1188	6.98	No	Yes	1	9	7
204	R:R:F1188	R:R:V1193	2.62	Yes	No	0	7	5
205	R:R:F1190	R:R:I1189	3.77	Yes	No	0	8	7
206	R:R:F1190	R:R:H1191	3.39	Yes	No	0	8	8
207	R:R:F1190	R:R:L1194	2.44	Yes	No	0	8	9
208	R:R:Q1195	R:R:V1198	2.87	No	No	0	8	9
209	R:R:K1196	R:R:R1199	2.48	No	No	0	9	7
210	R:R:V1198	R:R:Y1202	3.79	No	No	0	9	7
211	R:R:E1201	R:R:K1204	5.4	No	No	0	8	7
212	R:R:G1203	R:R:R1207	4.5	No	No	0	5	8
213	R:R:K1204	R:R:R1207	2.48	No	No	0	7	8
214	R:R:F1160	R:R:F1176	2.14	No	Yes	0	8	9
215	R:R:F1179	R:R:F1186	2.14	No	No	0	8	8
216	R:R:G1057	R:R:P1059	2.03	No	Yes	0	6	9
217	R:R:C1080	R:R:G1075	1.96	No	No	0	8	9
218	R:R:A1149	R:R:G1146	1.95	No	No	0	5	8
219	R:R:G1075	R:R:T1076	1.82	No	No	0	9	9
220	R:R:G1146	R:R:I1145	1.76	No	No	0	8	6
221	R:R:G1155	R:R:M1026	1.75	No	Yes	0	6	8
222	R:R:G952	R:R:L955	1.71	No	No	0	9	6
223	R:R:A1022	R:R:S987	1.71	No	Yes	0	8	8
224	R:R:G1030	R:R:L1033	1.71	No	No	0	5	9
225	R:R:G1030	R:R:L1154	1.71	No	Yes	0	5	6
226	R:R:G1108	R:R:L1107	1.71	No	No	0	5	8
227	R:R:M1058	R:R:P1059	1.68	No	Yes	0	4	9
228	R:R:C968	R:R:I964	1.64	No	No	0	8	7
229	R:R:L1020	R:R:P1095	1.64	Yes	No	0	9	9
230	R:R:A1159	R:R:I1100	1.62	No	No	0	7	9
231	R:R:V1079	R:R:V927	1.6	No	No	0	5	7
232	R:R:V947	R:R:V951	1.6	No	No	0	6	8
233	R:R:V1065	R:R:V1069	1.6	No	No	0	8	7
234	R:R:A1022	R:R:L988	1.58	No	No	0	8	9
235	R:R:P1005	R:R:Q1004	1.58	No	No	0	3	4
236	R:R:A1110	R:R:L1037	1.58	No	No	0	8	8
237	R:R:A1147	R:R:L1111	1.58	No	No	0	9	5
238	R:R:A926	R:R:N924	1.56	No	No	0	9	8
239	R:R:I1109	R:R:V1038	1.54	No	No	0	6	8
240	R:R:I1093	R:R:T1097	1.52	No	No	0	8	6
241	R:R:M1101	R:R:T1097	1.51	No	No	0	4	6
242	R:R:M1114	R:R:T1118	1.51	No	No	0	8	5
243	R:R:G972	R:R:R971	1.5	No	No	0	9	8
244	R:R:L943	R:R:V940	1.49	No	No	0	4	4
245	R:R:L955	R:R:V951	1.49	No	No	0	6	8
246	R:R:N978	R:R:S975	1.49	No	No	0	9	7
247	R:R:L1014	R:R:V1010	1.49	No	No	0	5	6
248	R:R:L1156	R:R:V1104	1.49	Yes	No	0	6	6
249	R:R:I1178	R:R:I948	1.47	No	No	0	5	9
250	R:R:I1171	R:R:M1172	1.46	No	Yes	0	6	8
251	R:R:I1189	R:R:M1185	1.46	No	No	0	7	7
252	R:R:I1062	R:R:L1061	1.43	No	No	0	8	5
253	R:R:I1100	R:R:L1156	1.43	No	Yes	0	9	6
254	R:R:I1105	R:R:L1102	1.43	No	No	0	5	4
255	R:R:K1197	R:R:L973	1.41	No	No	0	9	8
256	R:R:L1175	R:R:M1172	1.41	No	Yes	0	9	8
257	R:R:A1060	R:R:F1017	1.39	No	Yes	0	7	8
258	R:R:L954	R:R:L996	1.38	No	No	0	6	9
259	R:R:L1098	R:R:L1102	1.38	No	No	0	5	4
260	R:R:R1048	R:R:S1046	1.32	Yes	No	0	4	9
261	R:R:H1117	R:R:K1113	1.31	No	No	0	6	7
262	R:R:D1003	R:R:R1001	1.19	No	No	0	4	8
263	R:R:D1070	R:R:R1072	1.19	No	No	0	9	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S956	3.865	4	3	9
2	R:R:L960	3.0075	4	3	9
3	R:R:F967	3.81667	6	1	9
4	R:R:F970	4.242	5	0	8
5	R:R:I980	4.28	4	1	9
6	R:R:H981	7.1875	4	1	9
7	R:R:S987	2.535	4	1	8
8	R:R:H1016	5.16	4	6	9
9	R:R:F1017	4.7325	4	0	8
10	R:R:F1019	4.4075	4	0	9
11	R:R:L1020	3.826	5	6	9
12	R:R:F1023	4.964	5	0	9
13	R:R:W1025	6.37714	7	1	9
14	R:R:M1026	3.14	4	0	8
15	R:R:E1029	5.77	4	1	9
16	R:R:Q1032	3.178	5	1	8
17	R:R:R1048	2.965	4	1	4
18	R:R:Y1056	4.2025	4	1	9
19	R:R:P1059	2.676	5	0	9
20	R:R:Y1074	4.7	4	4	9
21	R:R:W1081	5.38	5	0	6
22	R:R:F1088	5.988	5	4	8
23	R:R:I1089	3.9225	4	2	9
24	R:R:W1090	3.7575	4	2	7
25	R:R:F1092	3.498	5	6	9
26	R:R:L1153	6.12	5	1	9
27	R:R:L1154	4.9025	4	0	6
28	R:R:L1156	2.115	4	0	6
29	R:R:W1158	7.156	5	5	8
30	R:R:M1172	3.045	4	0	8
31	R:R:Y1174	4.02	4	0	9
32	R:R:F1176	6.415	6	5	9
33	R:R:F1188	6.192	5	1	7
34	R:R:F1190	3.808	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L945	R:R:T1177	26.3649	4.42	No	No	0	8	9
2	R:R:T1177	R:R:T949	31.3751	3.14	No	No	0	9	8
3	R:R:F925	R:R:T949	33.0257	7.78	No	No	0	9	8
4	R:R:F1176	R:R:F925	42.3137	3.22	Yes	No	0	9	9
5	R:R:F1176	R:R:W1158	52.7298	4.01	Yes	Yes	5	9	8
6	R:R:F1023	R:R:W1158	42.4163	7.02	Yes	Yes	0	9	8
7	R:R:F1023	R:R:F1092	90.8536	3.22	Yes	Yes	0	9	9
8	R:R:F1019	R:R:F1092	12.3987	3.22	Yes	Yes	0	9	9
9	R:R:F995	R:R:L928	13.7172	3.65	No	No	0	8	9
10	R:R:F995	R:R:I999	12.0324	5.02	No	No	0	8	8
11	R:R:F1092	R:R:W1081	45.5709	4.01	Yes	Yes	0	9	6
12	R:R:I1089	R:R:W1081	16.2174	3.52	Yes	Yes	0	9	6
13	R:R:E1167	R:R:V1170	12.5745	4.28	No	No	0	5	4
14	R:R:V1170	R:R:Y1174	14.3325	2.52	No	Yes	0	4	9
15	R:R:L945	R:R:Y1174	21.2667	4.69	No	Yes	0	8	9
16	R:R:L1182	R:R:S1181	10.5577	3	No	No	0	6	7
17	R:R:L1182	R:R:M1185	11.9494	5.65	No	No	7	6	7
18	R:R:I1189	R:R:M1185	16.3786	1.46	No	No	0	7	7
19	R:R:F1190	R:R:I1189	17.8094	3.77	Yes	No	0	8	7
20	R:R:F1190	R:R:H1191	31.0431	3.39	Yes	No	0	8	8
21	R:R:H1191	R:R:L1153	31.9807	11.57	No	Yes	1	8	9
22	R:R:E1029	R:R:L1153	30.755	5.3	Yes	Yes	1	9	9
23	R:R:E1029	R:R:I980	81.087	6.83	Yes	Yes	1	9	9
24	R:R:I980	R:R:W1025	88.8026	4.7	Yes	Yes	1	9	9
25	R:R:L984	R:R:W1025	99.4042	2.28	No	Yes	0	9	9
26	R:R:L984	R:R:M1026	100	4.24	No	Yes	0	9	8
27	R:R:F1023	R:R:M1026	84.3051	2.49	Yes	Yes	0	9	8
28	R:R:C985	R:R:L960	10.4893	3.17	No	Yes	0	9	9
29	R:R:C985	R:R:F967	17.6677	2.79	No	Yes	0	9	9
30	R:R:F967	R:R:H981	52.5295	3.39	Yes	Yes	1	9	9
31	R:R:E1029	R:R:H981	48.369	8.62	Yes	Yes	1	9	9
32	R:R:F970	R:R:Y1202	14.6255	4.13	Yes	No	0	8	7
33	R:R:T966	R:R:Y1202	18.537	11.24	No	No	0	9	7
34	R:R:F967	R:R:T966	19.9482	3.89	Yes	No	0	9	9
35	R:R:I980	R:R:Q1032	16.2223	2.74	Yes	Yes	1	9	8
36	R:R:L1020	R:R:P1059	10.587	3.28	Yes	Yes	0	9	9
37	R:R:F1092	R:R:L1020	13.7709	3.65	Yes	Yes	6	9	9
38	R:R:C1008	R:R:R1001	15.2163	2.79	No	No	0	9	8
39	R:R:C1008	R:R:C1080	24.6264	7.28	No	No	0	9	8
40	R:R:C1080	R:R:G1075	26.4528	1.96	No	No	0	8	9
41	R:R:G1075	R:R:T1076	28.2694	1.82	No	No	0	9	9
42	R:R:R1083	R:R:T1076	30.0762	2.59	No	No	0	5	9
43	R:R:R1083	R:R:S1073	35.438	6.59	No	No	0	5	9
44	R:R:F1088	R:R:S1073	36.9128	5.28	Yes	No	4	8	9
45	R:R:F1088	R:R:L1082	49.1845	6.09	Yes	No	0	8	8
46	R:R:L1082	R:R:W1081	26.8972	11.39	No	Yes	0	8	6
47	R:R:H1016	R:R:L1082	24.309	2.57	Yes	No	0	9	8
48	R:R:F1092	R:R:H1016	26.8727	3.39	Yes	Yes	6	9	9
49	R:R:F1023	R:R:I1099	25.6422	3.77	Yes	No	0	9	5
50	R:R:M1026	R:R:Q1183	18.2391	4.08	Yes	No	0	8	9
51	R:R:Q1183	R:R:W1158	17.9363	6.57	No	Yes	0	9	8
52	R:R:F1027	R:R:I1099	24.4848	3.77	No	No	0	9	5
53	R:R:F1027	R:R:V1031	19.7529	5.24	No	No	0	9	9
54	R:R:F1106	R:R:V1031	18.6835	2.62	No	No	0	6	9
55	R:R:F1106	R:R:G1030	17.6238	6.02	No	No	0	6	5
56	R:R:G1030	R:R:L1154	12.931	1.71	No	Yes	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7WY5_nogp

PDB Summary
PDB	7WY5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.28
Number of Linked Nodes	241
Number of Links	263
Number of Hubs	34
Number of Links mediated by Hubs	129
Number of Communities	7
Number of Nodes involved in Communities	50
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	37468
Length Of Smallest Path	3
Average Path Length	13.8971
Length of Longest Path	33
Minimum Path Strength	1.405
Average Path Strength	4.52543
Maximum Path Strength	13.095
Minimum Path Correlation	0.7
Average Path Correlation	0.92683
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	50.7295
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.8438
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • ion binding • binding • calcium ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • molecular condensate scaffold activity • protein-macromolecule adaptor activity • molecular adaptor activity • cell adhesion molecule binding • protein binding • cell adhesion mediator activity • carbohydrate binding • developmental process • multicellular organismal process • nervous system development • excitatory synapse assembly • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • cellular process • synapse organization • cellular component organization or biogenesis
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • nervous system development • excitatory synapse assembly • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • cellular process • synapse organization • cellular component organization or biogenesis • synapse assembly • system development • positive regulation of nervous system development • regulation of cellular process • positive regulation of cellular component organization • regulation of cellular component organization • regulation of developmental process • positive regulation of biological process • regulation of nervous system development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of synapse structure or activity • regulation of synapse assembly • regulation of biological quality • positive regulation of cellular process • regulation of multicellular organismal development • regulation of biological process • positive regulation of cellular component biogenesis • biological regulation • regulation of cellular component biogenesis • regulation of cell junction assembly • positive regulation of cell junction assembly • regulation of synapse organization • positive regulation of multicellular organismal process • positive regulation of synapse assembly • cellular response to stimulus • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • Rho-activating G protein-coupled receptor signaling pathway • behavior • locomotory behavior • locomotion involved in locomotory behavior • locomotion • neuron migration • cellular developmental process • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • response to chemical • response to oxygen-containing compound • response to nitrogen compound • response to cocaine • response to alkaloid • maintenance of synapse structure • postsynapse organization • cellular component maintenance • cell junction maintenance • organelle organization • maintenance of postsynaptic specialization structure • postsynaptic density organization • postsynaptic specialization organization • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • cell-cell junction • anchoring junction • glutamatergic synapse • Schaffer collateral - CA1 synapse
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • cell-cell junction • anchoring junction • glutamatergic synapse • Schaffer collateral - CA1 synapse • axon • cell projection • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q80TS3
Sequence	>7WY5_nogp_Chain_R T N F A V L M A H V E V K H S D A V H D L L L D V I T W V G I L L S L V C L L I C I F T F C F F R G L Q S D R N T I H K N L C I S L F V A E L L F L I G I N R T D Q P I A C A V F A A L L H F F F L A A F T W M F L E G V Q L Y I M L V E V F E S E H S R R K Y F Y L V G Y G M P A L I V A V S A A V D Y R S Y G T D K V C W L R L D T Y F I W S F I G P A T L I I M L N V I F L G I A L Y K M F H H T W V I G A I A L L C L L G L T W A F G L M Y I N E S T V I M A Y L F T I F N S L Q G M F I F I F H C V L Q K K V R K E Y G K C L R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WY5	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WY5 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WY8	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WY8 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WYB	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	Gi1/β1/γ2	2.97	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WYB (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.97	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7X10	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-G12)/β1/γ2	2.93	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7X10 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.93	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7SF7	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	2.9	2022-04-27	doi.org/10.1038/s41586-022-04575-7
	7SF7 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-		2.9	2022-04-27	doi.org/10.1038/s41586-022-04575-7
	8JMT	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-	-	3.3	2023-09-06	doi.org/10.1038/s41589-023-01389-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WY5_nogp.zip

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