Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N50 5.26254269
2A:A:F212 6.8554109
3A:A:V214 2.79254106
4A:A:F219 6.1265108
5A:A:H220 7.765427
6A:A:F222 8.075427
7A:A:K233 3.7665149
8A:A:F238 6.9675409
9A:A:I244 2.54754248
10A:A:F246 3.9265259
11A:A:L270 4.124156
12A:A:W277 6.836276
13A:A:W281 6.928525
14A:A:L289 2.705409
15A:A:F290 4.4665209
16A:A:Q294 3.724166
17A:A:L297 2.1425408
18A:A:F312 2.483336158
19A:A:Y318 3.185406
20A:A:E330 5.4925403
21A:A:K338 5.684165
22A:A:Y339 5.3554163
23A:A:F340 7.14157
24A:A:R342 4.11254164
25A:A:F345 5.2725408
26A:A:F363 5.3625165
27A:A:R374 4.92754204
28A:A:F376 4.3525108
29A:A:I383 2.8225408
30A:A:Y391 6.3725404
31B:B:I37 3.9472
32B:B:V40 3.675673
33B:B:R52 4.985407
34B:B:H54 5.793336179
35B:B:K57 9.312529
36B:B:Y59 9.7428
37B:B:W63 4.30167667
38B:B:D76 3.9165239
39B:B:W82 8.2685179
40B:B:Y85 6.404584
41B:B:K89 5.7509
42B:B:I93 3.29407
43B:B:W99 5.985629
44B:B:Y105 3.076506
45B:B:C114 2.724218
46B:B:Y124 4.988336216
47B:B:H142 6.57659
48B:B:Y145 4.621258148
49B:B:C148 3.46436
50B:B:L152 4.96403
51B:B:T159 4.995459
52B:B:S160 2.4175436
53B:B:S161 7.6575459
54B:B:D163 8.48459
55B:B:T165 4.7675457
56B:B:L168 3.82436
57B:B:W169 8.744558
58B:B:Q176 7.0725454
59B:B:T178 3.6875434
60B:B:F180 4.25167637
61B:B:H183 6.71167639
62B:B:V187 3.8925439
63B:B:F199 4.155639
64B:B:V200 5.22446
65B:B:K209 8.8925436
66B:B:L210 5.5625445
67B:B:W211 5.685638
68B:B:Q220 5.425447
69B:B:F222 4.19833648
70B:B:H225 7.315649
71B:B:D228 7.274149
72B:B:I232 4.3275448
73B:B:F235 6.184297116
74B:B:F241 4.21429746
75B:B:T243 3.638548
76B:B:D247 6.21449
77B:B:R251 10.0825448
78B:B:F253 5.33446
79B:B:D254 2.0925409
80B:B:L255 3.884546
81B:B:D258 6.4025447
82B:B:Y264 6.053336125
83B:B:F278 5.5585117
84B:B:R283 5.39579
85B:B:Y289 5.6625127
86B:B:D290 7.02426
87B:B:N295 6.41254126
88B:B:H311 6.986599
89B:B:R314 11.72528
90B:B:L318 4.158566
91B:B:G319 1.994565
92B:B:T321 4.56467
93B:B:T329 5.0525408
94B:B:W332 8.85571729
95B:B:K337 6.0175496
96B:B:W339 7.4325499
97G:G:Y40 5.534116
98G:G:D48 4.368509
99G:G:L51 2.7375476
100G:G:N59 4.758589
101G:G:P60 6.5625489
102G:G:F61 4.43688
103R:R:S956 3.865419
104R:R:L960 3.0075419
105R:R:C963 3.11417
106R:R:F967 3.81667619
107R:R:F970 4.242508
108R:R:I980 4.28419
109R:R:H981 7.1875419
110R:R:C985 2.7625419
111R:R:S987 2.535418
112R:R:H1016 5.164309
113R:R:F1017 4.7325408
114R:R:F1019 4.4075409
115R:R:L1020 3.8265309
116R:R:F1023 4.964509
117R:R:W1025 6.37714719
118R:R:M1026 3.14408
119R:R:E1029 5.77419
120R:R:Q1032 3.178518
121R:R:F1041 3.2825109
122R:R:R1048 2.965414
123R:R:Y1056 4.2025419
124R:R:P1059 2.54167609
125R:R:Y1074 4.74199
126R:R:W1081 5.38506
127R:R:F1088 5.9885198
128R:R:I1089 3.92254139
129R:R:W1090 3.75754137
130R:R:F1092 3.4985309
131R:R:L1153 6.12519
132R:R:L1154 4.9025406
133R:R:L1156 2.115406
134R:R:W1158 7.1565228
135R:R:M1172 3.045408
136R:R:Y1174 4.02409
137R:R:F1176 6.4156229
138R:R:L1182 3.24186
139R:R:F1188 6.192517
140R:R:F1190 3.808508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:L41 A:A:T242 93.96762.95NoNo068
2A:A:C379 A:A:T242 94.06331.69NoNo088
3A:A:C379 A:A:I375 94.15861.64NoNo089
4A:A:I245 A:A:I375 94.34854.42NoNo079
5A:A:F290 A:A:I245 95.18782.51YesNo097
6A:A:F290 A:A:T364 96.44879.08YesNo2099
7A:A:N292 A:A:T364 98.76754.39NoNo099
8A:A:K293 A:A:N292 98.93584.2NoNo099
9A:A:D249 A:A:K293 99.01958.3NoNo089
10A:A:D249 A:A:S251 99.51524.42NoNo089
11A:A:K300 A:A:S251 99.6783.06NoNo099
12A:A:D252 A:A:K300 99.83964.15NoNo089
13A:A:D252 A:A:N264 1004.04NoNo089
14A:A:N264 A:A:Y311 97.311217.44NoNo096
15A:A:F312 A:A:Y311 97.38232.06YesNo086
16A:A:F312 A:A:L270 98.57722.44YesYes1586
17A:A:F345 A:A:L270 98.07868.53YesYes086
18A:A:F345 A:A:V248 48.67662.62YesNo087
19A:A:F246 A:A:V248 48.64072.62YesNo097
20A:A:F246 A:A:L46 63.7352.44YesNo098
21A:A:L44 A:A:L46 63.58864.15NoNo098
22A:A:F238 A:A:L44 62.750815.83YesNo099
23A:A:C237 A:A:F238 59.12362.79NoYes089
24A:A:C237 B:B:Y59 58.94472.69NoYes088
25B:B:W332 B:B:Y59 61.21829.65YesYes298
26B:B:S316 B:B:W332 38.26564.94NoYes099
27B:B:C317 B:B:S316 38.01123.44NoNo079
28B:B:C317 B:B:M61 24.22994.86NoNo076
29B:B:M61 B:B:W63 21.69325.82NoYes667
30A:A:F345 A:A:L289 48.93952.44YesYes089
31A:A:F246 A:A:L289 51.29592.44YesYes099
32A:A:L41 R:R:F1041 90.92482.44NoYes069
33A:A:W234 B:B:Y145 34.7621.93NoYes098
34B:B:D186 B:B:Y145 19.12089.2NoYes098
35B:B:D290 B:B:R314 30.28319.06YesYes268
36B:B:R314 B:B:W332 30.828417.99YesYes289
37A:A:R231 A:A:W234 35.83598NoNo099
38A:A:D272 A:A:F246 36.05598.36NoYes2589
39A:A:I383 R:R:F1041 92.76152.51YesYes089
40A:A:I383 A:A:N387 92.28234.25YesNo088
41A:A:Y391 R:R:M1036 33.12994.79YesNo048
42A:A:N387 R:R:M1036 92.17042.8NoNo088
43R:R:F967 R:R:H981 12.72753.39YesYes199
44R:R:H981 R:R:R977 18.80829.03YesNo199
45A:A:Y391 R:R:R977 27.157411.32YesNo049
46B:B:C271 B:B:D290 31.94171.56NoYes056
47B:B:C271 B:B:D291 31.73011.56NoNo058
48B:B:D291 B:B:Y289 31.31183.45NoYes087
49B:B:I273 B:B:Y289 22.36858.46NoYes067
50B:B:G244 B:B:I273 22.16015.29NoNo056
51B:B:G244 B:B:T243 19.27241.82NoYes058
52B:B:F241 B:B:T243 11.09742.59YesYes468
53B:B:T321 B:B:W63 12.20647.28YesYes677
54B:B:G324 B:B:T321 10.91021.82NoYes097
55B:B:G324 G:G:P49 10.65112.03NoNo097
56G:G:D48 G:G:P49 10.30733.22YesNo097
57B:B:D186 B:B:G162 17.51953.35NoNo099
58B:B:G162 B:B:S161 17.24141.86NoYes099
59B:B:H142 B:B:S161 15.237916.74YesYes599
60B:B:H142 B:B:T159 12.11826.85YesYes599
61B:B:C121 B:B:T159 10.74451.69NoYes089
62B:B:A113 B:B:C121 10.45961.81NoNo098
63B:B:M101 B:B:Y145 20.23533.59NoYes098
64B:B:G116 B:B:M101 20.00383.49NoNo099
65B:B:C148 B:B:T102 13.2723.38YesNo068
66R:R:M1036 R:R:Q1032 59.69884.08NoYes088
67R:R:I980 R:R:Q1032 57.5842.74YesYes198
68R:R:I980 R:R:W1025 53.194.7YesYes199
69R:R:L984 R:R:W1025 31.64452.28NoYes099
70R:R:L984 R:R:M1026 31.45524.24NoYes098
71R:R:F1023 R:R:M1026 23.48592.49YesYes098
72R:R:F1023 R:R:F1092 16.34763.22YesYes099
73R:R:F1176 R:R:W1158 13.80774.01YesYes2298
74R:R:F1176 R:R:F925 10.82523.22YesNo099
75R:R:H1191 R:R:L1153 11.311.57NoYes189
76R:R:F1190 R:R:H1191 10.75463.39YesNo088
77R:R:E1029 R:R:L1153 17.07515.3YesYes199
78R:R:E1029 R:R:I980 11.66986.83YesYes199
79R:R:L957 R:R:S956 13.10053NoYes199
80R:R:I1187 R:R:L1153 12.48922.85NoYes199
81R:R:G1184 R:R:I1187 11.94621.76NoNo189
82R:R:G1184 R:R:S956 11.17863.71NoYes189
83R:R:A1021 R:R:P1059 13.23681.87NoYes089
84R:R:L957 R:R:L993 12.28631.38NoNo095
85R:R:I997 R:R:L993 11.46934.28NoNo055
86R:R:G998 R:R:I997 10.6523.53NoNo095
87R:R:H1016 R:R:L1082 10.83252.57YesNo098
88R:R:F1088 R:R:L1082 12.64936.09YesNo088
89R:R:L1020 R:R:P1059 14.99083.28YesYes099
90R:R:H1016 R:R:L1020 11.71027.71YesYes3099
91B:B:C317 B:B:G330 13.64871.96NoNo075
92B:B:G115 B:B:G116 19.79612.11NoNo099
93A:A:D272 A:A:R231 35.931910.72NoNo089
94B:B:G115 B:B:T102 13.79421.82NoNo098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WY5
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRL3
Species Mus musculus
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.83
Date 2022-10-26 
D.O.I. 10.1016/j.molcel.2022.10.009
Net Summary
Imin 1.71
Number of Linked Nodes 824
Number of Links 969
Number of Hubs 140
Number of Links mediated by Hubs 518
Number of Communities 30
Number of Nodes involved in Communities 209
Number of Links involved in Communities 287
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 983061
Length Of Smallest Path 3
Average Path Length 34.771
Length of Longest Path 67
Minimum Path Strength 1.16
Average Path Strength 4.84699
Maximum Path Strength 18.525
Minimum Path Correlation 0.71
Average Path Correlation 0.978618
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.17391
Average % Of Corr. Nodes 39.1528
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.2366
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7WY5_Chain_A
EDKAAVERS KMIEKQLQK DKQVYRRTL RLLLLGADN SGKSTIVKQ 
MRITSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ CFNDVTAII 
FVVDSSDNR LQEALNDFK SIWNNRWLR TISVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRKEFV 
DISTASGDG RHICYPHFT CSVDTENAR RIFNDCKDI ILQMNLREY 
NLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WY5_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WY5_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ80TS3
Sequence
>7WY5_Chain_R
TNFAVLMAH VEVKHSDAV HDLLLDVIT WVGILLSLV CLLICIFTF 
CFFRGLQSD RNTIHKNLC ISLFVAELL FLIGINRTD QPIACAVFA 
ALLHFFFLA AFTWMFLEG VQLYIMLVE VFESEHSRR KYFYLVGYG 
MPALIVAVS AAVDYRSYG TDKVCWLRL DTYFIWSFI GPATLIIML 
NVIFLGIAL YKMFHHTWV IGAIALLCL LGLTWAFGL MYINESTVI 
MAYLFTIFN SLQGMFIFI FHCVLQKKV RKEYGKCLR T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SF7B2AdhesionAdhesionADGRL3Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;22.92022-04-2710.1038/s41586-022-04575-7
7WY5B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WY8B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WYBB2AdhesionAdhesionADGRL3Mus musculus--Gi1/&β;1/&γ;22.972022-10-2610.1016/j.molcel.2022.10.009
7X10B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-G12)/&β;1/&γ;22.932022-10-2610.1016/j.molcel.2022.10.009
8JMTB2AdhesionAdhesionADGRL3Homo sapiens---3.32023-09-0610.1038/s41589-023-01389-0




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Download 7WY5.zip



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